ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand elongation involved in DNA replication (GO:0006271)	5.37685591
2	DNA unwinding involved in DNA replication (GO:0006268)	5.24332037
3	DNA strand elongation (GO:0022616)	5.18563704
4	DNA replication checkpoint (GO:0000076)	4.92485250
5	telomere maintenance via semi-conservative replication (GO:0032201)	4.87676632
6	ribosomal small subunit biogenesis (GO:0042274)	4.79112464
7	chromatin remodeling at centromere (GO:0031055)	4.40822898
8	DNA strand renaturation (GO:0000733)	4.40500727
9	DNA replication initiation (GO:0006270)	4.29726980
10	L-serine metabolic process (GO:0006563)	4.24968100
11	CENP-A containing nucleosome assembly (GO:0034080)	4.24433925
12	heterochromatin organization (GO:0070828)	4.15892544
13	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.14363453
14	maturation of SSU-rRNA (GO:0030490)	4.13110898
15	mitotic chromosome condensation (GO:0007076)	4.10283573
16	kinetochore organization (GO:0051383)	4.03493738
17	protein localization to chromosome, centromeric region (GO:0071459)	4.01191873
18	kinetochore assembly (GO:0051382)	3.97469838
19	telomere maintenance via recombination (GO:0000722)	3.96962107
20	establishment of integrated proviral latency (GO:0075713)	3.96218768
21	ribosomal small subunit assembly (GO:0000028)	3.86135295
22	mitotic sister chromatid segregation (GO:0000070)	3.79423375
23	regulation of mitochondrial translation (GO:0070129)	3.77626359
24	mitotic recombination (GO:0006312)	3.74603763
25	DNA replication-independent nucleosome organization (GO:0034724)	3.67451586
26	DNA replication-independent nucleosome assembly (GO:0006336)	3.67451586
27	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.67007121
28	meiotic chromosome segregation (GO:0045132)	3.65026810
29	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.64025071
30	ribonucleoprotein complex biogenesis (GO:0022613)	3.61533413
31	viral transcription (GO:0019083)	3.60886465
32	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.59152469
33	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.56520644
34	DNA replication-dependent nucleosome organization (GO:0034723)	3.55501890
35	DNA replication-dependent nucleosome assembly (GO:0006335)	3.55501890
36	protein localization to kinetochore (GO:0034501)	3.52156148
37	GDP-mannose metabolic process (GO:0019673)	3.51670244
38	pyrimidine nucleotide catabolic process (GO:0006244)	3.51662009
39	translational termination (GO:0006415)	3.51085107
40	ribosome biogenesis (GO:0042254)	3.49845294
41	chromatin assembly or disassembly (GO:0006333)	3.47733315
42	formation of translation preinitiation complex (GO:0001731)	3.47338806
43	base-excision repair (GO:0006284)	3.46995782
44	base-excision repair, AP site formation (GO:0006285)	3.42961147
45	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.42550886
46	mitotic metaphase plate congression (GO:0007080)	3.40917306
47	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.38391192
48	DNA duplex unwinding (GO:0032508)	3.37357202
49	sister chromatid segregation (GO:0000819)	3.37058208
50	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.35852287
51	regulation of translational fidelity (GO:0006450)	3.34013202
52	pseudouridine synthesis (GO:0001522)	3.33992546
53	nucleobase biosynthetic process (GO:0046112)	3.29424276
54	proline biosynthetic process (GO:0006561)	3.28213374
55	histone exchange (GO:0043486)	3.26856407
56	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.26204772
57	DNA geometric change (GO:0032392)	3.25482145
58	telomere maintenance via telomere lengthening (GO:0010833)	3.23165322
59	folic acid metabolic process (GO:0046655)	3.21368885
60	negative regulation of mRNA processing (GO:0050686)	3.18952107
61	translational elongation (GO:0006414)	3.18495619
62	DNA ligation (GO:0006266)	3.17288794
63	chromatin assembly (GO:0031497)	3.15558757
64	UTP biosynthetic process (GO:0006228)	3.15442952
65	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.12862613
66	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.11587043
67	ribosomal large subunit biogenesis (GO:0042273)	3.11066480
68	peptidyl-arginine omega-N-methylation (GO:0035247)	3.08982352
69	negative regulation of cell aging (GO:0090344)	3.05594179
70	rRNA processing (GO:0006364)	3.04775810
71	establishment of viral latency (GO:0019043)	3.04743573
72	purine nucleobase biosynthetic process (GO:0009113)	3.04422865
73	viral mRNA export from host cell nucleus (GO:0046784)	3.03074564
74	CTP metabolic process (GO:0046036)	3.03062881
75	CTP biosynthetic process (GO:0006241)	3.03062881
76	negative regulation of RNA splicing (GO:0033119)	3.01257390
77	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.00297074
78	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.96384587
79	histone arginine methylation (GO:0034969)	2.96189260
80	cellular component biogenesis (GO:0044085)	2.95377135
81	translational initiation (GO:0006413)	2.94664800
82	ATP-dependent chromatin remodeling (GO:0043044)	2.94506089
83	mitotic nuclear envelope disassembly (GO:0007077)	2.93224732
84	nucleobase-containing small molecule interconversion (GO:0015949)	2.91755756
85	transcription-coupled nucleotide-excision repair (GO:0006283)	2.91286844
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.90440916
87	deoxyribonucleotide catabolic process (GO:0009264)	2.89930233
88	cotranslational protein targeting to membrane (GO:0006613)	2.89189325
89	rRNA modification (GO:0000154)	2.88929305
90	serine family amino acid biosynthetic process (GO:0009070)	2.88570333
91	rRNA transcription (GO:0009303)	2.88359279
92	DNA conformation change (GO:0071103)	2.87521676
93	rRNA metabolic process (GO:0016072)	2.87131910
94	protein targeting to ER (GO:0045047)	2.86663661
95	DNA replication (GO:0006260)	2.86336347
96	viral life cycle (GO:0019058)	2.85377274
97	cellular protein complex disassembly (GO:0043624)	2.81977003
98	GTP biosynthetic process (GO:0006183)	2.81761788
99	UTP metabolic process (GO:0046051)	2.81051206
100	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.80995671

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.28094118
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.77326007
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.38539278
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.30746017
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.27546759
6	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.91449125
7	XRN2_22483619_ChIP-Seq_HELA_Human	2.88390307
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.87025441
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.86078130
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.82386001
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.64227317
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.55194157
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.49667728
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39494536
15	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.32981794
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.28145476
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.21376737
18	VDR_21846776_ChIP-Seq_THP-1_Human	2.12502918
19	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08637005
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.07751650
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.01558812
22	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.98475460
23	DCP1A_22483619_ChIP-Seq_HELA_Human	1.98393370
24	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.97109057
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.96873116
26	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.94080906
27	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.93118511
28	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.90526847
29	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.89735376
30	* E2F1_21310950_ChIP-Seq_MCF-7_Human	1.88437116
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.86789358
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.86321270
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.80187726
34	MYC_22102868_ChIP-Seq_BL_Human	1.78192181
35	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.74123502
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.73199198
37	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.62737610
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.58787358
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.58362025
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.56073219
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51593200
42	* MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50751888
43	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49922708
44	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.48668256
45	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.47512492
46	CIITA_25753668_ChIP-Seq_RAJI_Human	1.43657080
47	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.39596499
48	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.39529309
49	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.38591914
50	AR_21909140_ChIP-Seq_LNCAP_Human	1.37394204
51	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.36663079
52	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.36523573
53	* P68_20966046_ChIP-Seq_HELA_Human	1.36380936
54	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.34707803
55	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.34131346
56	VDR_23849224_ChIP-Seq_CD4+_Human	1.33969933
57	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.32460761
58	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.32206099
59	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.30653493
60	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30371072
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.28600629
62	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.26642385
63	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.24918742
64	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23876169
65	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22719682
66	LXR_22292898_ChIP-Seq_THP-1_Human	1.21770162
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.19938496
68	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.18225695
69	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.17412845
70	ZNF263_19887448_ChIP-Seq_K562_Human	1.17207229
71	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.17184184
72	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.13781400
73	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.12160370
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.09136877
75	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09005530
76	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.08879055
77	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05434350
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.04686985
79	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.02617646
80	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.01594293
81	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.99721909
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99659708
83	* PHF8_20622854_ChIP-Seq_HELA_Human	0.98878277
84	RACK7_27058665_Chip-Seq_MCF-7_Human	0.97945728
85	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.97835728
86	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.97746117
87	* MAF_26560356_Chip-Seq_TH2_Human	0.95808880
88	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.95194335
89	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92687228
90	* ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92603821
91	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.91644219
92	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.91339354
93	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.91170953
94	CTCF_21964334_Chip-Seq_Bcells_Human	0.90999148
95	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.90112261
96	* E2F1_20622854_ChIP-Seq_HELA_Human	0.89935529
97	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89603896
98	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.89043498
99	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.88991195
100	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.87627257

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003111_abnormal_nucleus_morphology	4.78892231
2	MP0010094_abnormal_chromosome_stability	4.71962578
3	MP0003693_abnormal_embryo_hatching	4.57172487
4	MP0004957_abnormal_blastocyst_morpholog	3.93869337
5	MP0003077_abnormal_cell_cycle	3.70953453
6	MP0008058_abnormal_DNA_repair	3.50708192
7	MP0008057_abnormal_DNA_replication	3.15784920
8	MP0008932_abnormal_embryonic_tissue	3.01808834
9	MP0005171_absent_coat_pigmentation	2.52175212
10	MP0010030_abnormal_orbit_morphology	2.29642566
11	MP0008007_abnormal_cellular_replicative	2.29616760
12	MP0009379_abnormal_foot_pigmentation	2.20989265
13	MP0003136_yellow_coat_color	2.20774945
14	MP0006292_abnormal_olfactory_placode	2.13363538
15	MP0000350_abnormal_cell_proliferation	1.91718391
16	MP0001730_embryonic_growth_arrest	1.78716093
17	MP0003718_maternal_effect	1.78072745
18	MP0003786_premature_aging	1.77584520
19	MP0005174_abnormal_tail_pigmentation	1.73810514
20	MP0001661_extended_life_span	1.71354650
21	MP0002160_abnormal_reproductive_system	1.65153181
22	MP0001293_anophthalmia	1.63279361
23	MP0001697_abnormal_embryo_size	1.62180149
24	MP0001188_hyperpigmentation	1.58786986
25	MP0001672_abnormal_embryogenesis/_devel	1.57539519
26	MP0005380_embryogenesis_phenotype	1.57539519
27	MP0002080_prenatal_lethality	1.54419837
28	MP0002085_abnormal_embryonic_tissue	1.45787494
29	MP0005501_abnormal_skin_physiology	1.40722423
30	MP0003806_abnormal_nucleotide_metabolis	1.40602466
31	MP0000313_abnormal_cell_death	1.38708761
32	MP0003984_embryonic_growth_retardation	1.35452575
33	MP0001346_abnormal_lacrimal_gland	1.34173787
34	MP0002210_abnormal_sex_determination	1.32623160
35	MP0009672_abnormal_birth_weight	1.32165121
36	MP0000358_abnormal_cell_content/	1.31740066
37	MP0002088_abnormal_embryonic_growth/wei	1.28110129
38	MP0004185_abnormal_adipocyte_glucose	1.27190967
39	MP0003705_abnormal_hypodermis_morpholog	1.26308852
40	MP0002084_abnormal_developmental_patter	1.25143572
41	MP0003315_abnormal_perineum_morphology	1.25120473
42	MP0004233_abnormal_muscle_weight	1.22858468
43	MP0003123_paternal_imprinting	1.22782150
44	MP0005076_abnormal_cell_differentiation	1.22569164
45	MP0004197_abnormal_fetal_growth/weight/	1.20979330
46	MP0003937_abnormal_limbs/digits/tail_de	1.15942709
47	MP0000049_abnormal_middle_ear	1.15385256
48	MP0005423_abnormal_somatic_nervous	1.14711027
49	MP0000490_abnormal_crypts_of	1.14457057
50	MP0002697_abnormal_eye_size	1.13137299
51	MP0006035_abnormal_mitochondrial_morpho	1.10488543
52	MP0000566_synostosis	1.10289223
53	MP0002019_abnormal_tumor_incidence	1.07940005
54	MP0005083_abnormal_biliary_tract	1.07755573
55	MP0010307_abnormal_tumor_latency	1.05106872
56	MP0001145_abnormal_male_reproductive	1.03738088
57	MP0009278_abnormal_bone_marrow	1.03681797
58	MP0002938_white_spotting	1.02793847
59	MP0008995_early_reproductive_senescence	0.99606892
60	MP0000537_abnormal_urethra_morphology	0.97957978
61	MP0002111_abnormal_tail_morphology	0.96849872
62	MP0001929_abnormal_gametogenesis	0.95312829
63	MP0001986_abnormal_taste_sensitivity	0.95217456
64	MP0005330_cardiomyopathy	0.94811736
65	MP0002249_abnormal_larynx_morphology	0.93340822
66	MP0002086_abnormal_extraembryonic_tissu	0.92176526
67	MP0000750_abnormal_muscle_regeneration	0.90741571
68	MP0006036_abnormal_mitochondrial_physio	0.90077667
69	MP0003878_abnormal_ear_physiology	0.89410467
70	MP0005377_hearing/vestibular/ear_phenot	0.89410467
71	MP0002163_abnormal_gland_morphology	0.86273946
72	MP0000653_abnormal_sex_gland	0.86202767
73	MP0002092_abnormal_eye_morphology	0.84890087
74	MP0008789_abnormal_olfactory_epithelium	0.83580224
75	MP0005499_abnormal_olfactory_system	0.82309095
76	MP0005394_taste/olfaction_phenotype	0.82309095
77	MP0003186_abnormal_redox_activity	0.81385408
78	MP0000751_myopathy	0.81286526
79	MP0003861_abnormal_nervous_system	0.80748911
80	MP0003119_abnormal_digestive_system	0.77065544
81	MP0001286_abnormal_eye_development	0.76454041
82	MP0001849_ear_inflammation	0.75777521
83	MP0003698_abnormal_male_reproductive	0.73200636
84	MP0001919_abnormal_reproductive_system	0.72727969
85	MP0000678_abnormal_parathyroid_gland	0.72616063
86	MP0005389_reproductive_system_phenotype	0.72385816
87	MP0002736_abnormal_nociception_after	0.71213957
88	MP0009697_abnormal_copulation	0.70696752
89	MP0005384_cellular_phenotype	0.68563179
90	MP0005257_abnormal_intraocular_pressure	0.68209395
91	MP0002161_abnormal_fertility/fecundity	0.68095111
92	MP0001529_abnormal_vocalization	0.67798028
93	MP0003890_abnormal_embryonic-extraembry	0.67305988
94	MP0003942_abnormal_urinary_system	0.66596219
95	MP0003567_abnormal_fetal_cardiomyocyte	0.65279101
96	MP0008875_abnormal_xenobiotic_pharmacok	0.64246118
97	MP0003699_abnormal_female_reproductive	0.62333736
98	MP0001119_abnormal_female_reproductive	0.59301971
99	MP0002233_abnormal_nose_morphology	0.58303998
100	MP0005220_abnormal_exocrine_pancreas	0.57198802

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	4.39835773
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.37639923
3	Reticulocytopenia (HP:0001896)	4.32408694
4	Birth length less than 3rd percentile (HP:0003561)	3.95578326
5	Rib fusion (HP:0000902)	3.90912714
6	Chromsome breakage (HP:0040012)	3.87357187
7	Microvesicular hepatic steatosis (HP:0001414)	3.65203065
8	Abnormality of cells of the erythroid lineage (HP:0012130)	3.61663278
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.57812508
10	Abnormal number of erythroid precursors (HP:0012131)	3.40076857
11	Rectovaginal fistula (HP:0000143)	3.36534261
12	Rectal fistula (HP:0100590)	3.36534261
13	Absent thumb (HP:0009777)	3.34077342
14	Poikiloderma (HP:0001029)	3.33413702
15	Increased hepatocellular lipid droplets (HP:0006565)	3.26161076
16	Vaginal fistula (HP:0004320)	3.19516859
17	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.11476112
18	Squamous cell carcinoma (HP:0002860)	3.06939708
19	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.04840289
20	Lipid accumulation in hepatocytes (HP:0006561)	3.03581193
21	Intestinal fistula (HP:0100819)	3.01346743
22	Patellar aplasia (HP:0006443)	2.95395301
23	Progressive muscle weakness (HP:0003323)	2.90040275
24	Ulnar bowing (HP:0003031)	2.85165342
25	Absent radius (HP:0003974)	2.82774372
26	Meckel diverticulum (HP:0002245)	2.81767181
27	Aplasia/Hypoplasia of the patella (HP:0006498)	2.77528192
28	Facial hemangioma (HP:0000329)	2.75821540
29	Dyschromatopsia (HP:0007641)	2.67376553
30	Renal Fanconi syndrome (HP:0001994)	2.66223917
31	Aplasia involving forearm bones (HP:0009822)	2.63383087
32	Absent forearm bone (HP:0003953)	2.63383087
33	Abnormality of the ileum (HP:0001549)	2.63267519
34	Macrocytic anemia (HP:0001972)	2.62703523
35	Broad distal phalanx of finger (HP:0009836)	2.61776928
36	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.59901184
37	Increased intramyocellular lipid droplets (HP:0012240)	2.55570795
38	Abnormality of the preputium (HP:0100587)	2.55019511
39	Breast hypoplasia (HP:0003187)	2.50191725
40	Short thumb (HP:0009778)	2.46152245
41	Duplication of thumb phalanx (HP:0009942)	2.45256475
42	Horseshoe kidney (HP:0000085)	2.28528220
43	Increased muscle lipid content (HP:0009058)	2.26106379
44	Pallor (HP:0000980)	2.25767611
45	Turricephaly (HP:0000262)	2.25113548
46	Increased CSF lactate (HP:0002490)	2.22653629
47	Respiratory difficulties (HP:0002880)	2.20753415
48	Mitochondrial inheritance (HP:0001427)	2.20114684
49	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.19039939
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.18478002
51	Hypoplasia of the pons (HP:0012110)	2.12685032
52	Acute necrotizing encephalopathy (HP:0006965)	2.12543446
53	Annular pancreas (HP:0001734)	2.10469813
54	Acute encephalopathy (HP:0006846)	2.10151930
55	Triphalangeal thumb (HP:0001199)	2.06284072
56	Abnormality of DNA repair (HP:0003254)	2.05981982
57	Progressive external ophthalmoplegia (HP:0000590)	2.04541867
58	Delayed epiphyseal ossification (HP:0002663)	2.04295704
59	Abnormality of the intrinsic pathway (HP:0010989)	2.03535004
60	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.03260951
61	Abnormality of chromosome stability (HP:0003220)	2.03134518
62	Coronal craniosynostosis (HP:0004440)	2.02388376
63	Ragged-red muscle fibers (HP:0003200)	2.00957596
64	Ectopic kidney (HP:0000086)	1.99592773
65	Impulsivity (HP:0100710)	1.98790596
66	Exercise intolerance (HP:0003546)	1.98123179
67	High anterior hairline (HP:0009890)	1.97633257
68	Abnormality of the carotid arteries (HP:0005344)	1.97487674
69	Colon cancer (HP:0003003)	1.96497126
70	Myelodysplasia (HP:0002863)	1.96472682
71	Absent epiphyses (HP:0010577)	1.94632589
72	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.94632589
73	Cerebral edema (HP:0002181)	1.92899141
74	Hypoplasia of the radius (HP:0002984)	1.91819105
75	Selective tooth agenesis (HP:0001592)	1.91555229
76	Small intestinal stenosis (HP:0012848)	1.91529422
77	Duodenal stenosis (HP:0100867)	1.91529422
78	Increased nuchal translucency (HP:0010880)	1.91140088
79	Abnormal number of incisors (HP:0011064)	1.90906742
80	Increased serum lactate (HP:0002151)	1.89573861
81	Abnormality of reticulocytes (HP:0004312)	1.88717164
82	Capillary hemangiomas (HP:0005306)	1.88187327
83	Hepatocellular necrosis (HP:0001404)	1.87941024
84	Type I transferrin isoform profile (HP:0003642)	1.86282137
85	Slender long bone (HP:0003100)	1.82613247
86	Mesangial abnormality (HP:0001966)	1.82547570
87	Abnormality of cochlea (HP:0000375)	1.81656137
88	Microretrognathia (HP:0000308)	1.80441886
89	Abnormality of the pons (HP:0007361)	1.79785095
90	Partial duplication of thumb phalanx (HP:0009944)	1.76870707
91	Lactic acidosis (HP:0003128)	1.73971810
92	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72808955
93	Megaloblastic anemia (HP:0001889)	1.71585612
94	Muscle fiber atrophy (HP:0100295)	1.69416883
95	Anteriorly placed anus (HP:0001545)	1.67906707
96	Exertional dyspnea (HP:0002875)	1.67770398
97	Multiple enchondromatosis (HP:0005701)	1.65242706
98	Optic nerve coloboma (HP:0000588)	1.64348632
99	Duplicated collecting system (HP:0000081)	1.63728252
100	Choanal stenosis (HP:0000452)	1.62540517

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.43530436
2	BUB1	3.94315078
3	NME2	3.55322120
4	VRK2	3.39064234
5	ZAK	2.82426702
6	TTK	2.81787696
7	SRPK1	2.50758099
8	STK16	2.47954518
9	SMG1	2.19228791
10	PBK	2.06099955
11	TESK2	2.04372786
12	CHEK2	2.02775939
13	MAPK15	2.02281584
14	NEK1	2.01719571
15	PLK1	1.86368357
16	AURKA	1.84996717
17	KDR	1.84864625
18	BCKDK	1.77527478
19	ATR	1.76719737
20	TRIB3	1.73093005
21	ICK	1.72092236
22	PLK4	1.71489174
23	MAP3K10	1.71107042
24	WEE1	1.65977944
25	SCYL2	1.64263197
26	NEK2	1.62561443
27	VRK1	1.52527871
28	EEF2K	1.51106836
29	ARAF	1.47993581
30	CDK7	1.47392355
31	CDK4	1.46416596
32	AURKB	1.45617274
33	TLK1	1.44322929
34	BRAF	1.38337541
35	BRSK1	1.32387679
36	CHEK1	1.22007075
37	RPS6KB2	1.20305037
38	CDK19	1.19000225
39	CDK8	1.14971912
40	TSSK6	1.10626686
41	MAP3K8	1.08039490
42	PLK3	1.07732511
43	EIF2AK1	1.05802413
44	TAF1	1.02991725
45	DYRK2	0.99065847
46	DYRK3	0.95338082
47	STK4	0.95113636
48	RPS6KA5	0.93839800
49	PIM2	0.92675205
50	NME1	0.88940425
51	PASK	0.88750660
52	CDK12	0.88628370
53	CCNB1	0.87563623
54	TRIM28	0.85855301
55	MKNK1	0.84572855
56	CDK11A	0.84408968
57	CDK2	0.83226993
58	ATM	0.81496777
59	CDK1	0.80897591
60	IRAK3	0.79118184
61	CDK15	0.78374357
62	WNK4	0.76869830
63	PAK1	0.76610978
64	BRSK2	0.76417474
65	CDK18	0.72382708
66	MUSK	0.71299689
67	BMX	0.71212871
68	PDK2	0.65121109
69	CDK14	0.63187717
70	RPS6KA4	0.57922393
71	AKT2	0.56978130
72	PAK4	0.56487100
73	CSNK2A1	0.54528135
74	MTOR	0.52486708
75	CSNK2A2	0.50718715
76	ABL2	0.50491288
77	LRRK2	0.47818680
78	PRKCI	0.47392793
79	MAP3K11	0.47052644
80	CSNK1G3	0.44520468
81	PRKDC	0.43294161
82	PIM1	0.41891217
83	RPS6KL1	0.41447255
84	RPS6KC1	0.41447255
85	RPS6KA1	0.41053420
86	EPHA2	0.40990839
87	MAPK11	0.40939028
88	SIK1	0.39476632
89	PKN2	0.38336303
90	MAP2K2	0.35724887
91	CSNK1E	0.33984928
92	DAPK3	0.33799852
93	RPS6KA6	0.32954558
94	AKT1	0.32494610
95	DAPK1	0.32415566
96	PRKD3	0.32128801
97	MAPK14	0.30694339
98	CAMK1D	0.29481983
99	IRAK2	0.28622966
100	CSNK1G1	0.27648697

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.18114281
2	Base excision repair_Homo sapiens_hsa03410	3.88357485
3	Mismatch repair_Homo sapiens_hsa03430	3.75918955
4	Ribosome_Homo sapiens_hsa03010	3.35131194
5	Sulfur relay system_Homo sapiens_hsa04122	3.01421113
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.76518357
7	Homologous recombination_Homo sapiens_hsa03440	2.71691107
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.59947598
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43648875
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.37535280
11	Nucleotide excision repair_Homo sapiens_hsa03420	2.35381961
12	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.35103374
13	Spliceosome_Homo sapiens_hsa03040	2.33637083
14	Cell cycle_Homo sapiens_hsa04110	2.31536558
15	RNA polymerase_Homo sapiens_hsa03020	2.29364688
16	One carbon pool by folate_Homo sapiens_hsa00670	2.23281640
17	Non-homologous end-joining_Homo sapiens_hsa03450	2.08968114
18	RNA transport_Homo sapiens_hsa03013	2.08788572
19	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.96679325
20	Proteasome_Homo sapiens_hsa03050	1.95466198
21	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.92985243
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.91731845
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.65742749
24	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.41343493
25	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.39471289
26	Parkinsons disease_Homo sapiens_hsa05012	1.31995129
27	mRNA surveillance pathway_Homo sapiens_hsa03015	1.28234769
28	Purine metabolism_Homo sapiens_hsa00230	1.23963005
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.22443838
30	Oxidative phosphorylation_Homo sapiens_hsa00190	1.20874006
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.18794830
32	Huntingtons disease_Homo sapiens_hsa05016	1.17473257
33	RNA degradation_Homo sapiens_hsa03018	1.12496668
34	Carbon metabolism_Homo sapiens_hsa01200	1.12372577
35	Basal transcription factors_Homo sapiens_hsa03022	1.07497231
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.05555095
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.05411013
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.05240809
39	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.04463004
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93482506
41	Folate biosynthesis_Homo sapiens_hsa00790	0.92628796
42	Pentose phosphate pathway_Homo sapiens_hsa00030	0.91442219
43	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87743350
44	Glutathione metabolism_Homo sapiens_hsa00480	0.82044681
45	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.81563362
46	p53 signaling pathway_Homo sapiens_hsa04115	0.80510197
47	Alcoholism_Homo sapiens_hsa05034	0.79851884
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.78277293
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78275529
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.77780861
51	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.75445940
52	Fatty acid elongation_Homo sapiens_hsa00062	0.73384878
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.68911700
54	Oocyte meiosis_Homo sapiens_hsa04114	0.67736761
55	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.67653247
56	Galactose metabolism_Homo sapiens_hsa00052	0.66489413
57	Lysine degradation_Homo sapiens_hsa00310	0.63519992
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61265586
59	Metabolic pathways_Homo sapiens_hsa01100	0.61235486
60	Alzheimers disease_Homo sapiens_hsa05010	0.60259576
61	Bladder cancer_Homo sapiens_hsa05219	0.58350389
62	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57415725
63	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56811684
64	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.55912283
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.52000716
66	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50116191
67	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.47766838
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.46582732
69	Hippo signaling pathway_Homo sapiens_hsa04390	0.45108151
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.39250432
71	Viral carcinogenesis_Homo sapiens_hsa05203	0.38115798
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36603689
73	Protein export_Homo sapiens_hsa03060	0.36044504
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.35492054
75	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.35462358
76	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34776241
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33122723
78	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.32430760
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31355209
80	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30560938
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.30142749
82	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29369678
83	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.28903653
84	HTLV-I infection_Homo sapiens_hsa05166	0.28259679
85	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28248318
86	Thyroid cancer_Homo sapiens_hsa05216	0.26736465
87	Phenylalanine metabolism_Homo sapiens_hsa00360	0.26274478
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22090744
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.21044391
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.19674106
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.19279638
92	Notch signaling pathway_Homo sapiens_hsa04330	0.19188152
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.17577677
94	Arginine biosynthesis_Homo sapiens_hsa00220	0.15010096
95	Melanoma_Homo sapiens_hsa05218	0.14574334
96	Wnt signaling pathway_Homo sapiens_hsa04310	0.14143457
97	mTOR signaling pathway_Homo sapiens_hsa04150	0.12100597
98	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.10161607
99	Colorectal cancer_Homo sapiens_hsa05210	0.10087717
100	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.09750102

C16ORF59

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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