ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.28177637
2	gamma-aminobutyric acid transport (GO:0015812)	4.20306136
3	platelet dense granule organization (GO:0060155)	4.15730229
4	behavioral response to nicotine (GO:0035095)	4.13409564
5	water-soluble vitamin biosynthetic process (GO:0042364)	3.91957366
6	postsynaptic membrane organization (GO:0001941)	3.66403032
7	protein polyglutamylation (GO:0018095)	3.65985647
8	nonmotile primary cilium assembly (GO:0035058)	3.65668433
9	cellular ketone body metabolic process (GO:0046950)	3.51458362
10	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.45610980
11	protein complex biogenesis (GO:0070271)	3.43065154
12	DNA deamination (GO:0045006)	3.37795026
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.37752976
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.37752976
15	retinal cone cell development (GO:0046549)	3.32041115
16	regulation of cilium movement (GO:0003352)	3.30830459
17	respiratory chain complex IV assembly (GO:0008535)	3.30542777
18	presynaptic membrane assembly (GO:0097105)	3.29711307
19	protein-cofactor linkage (GO:0018065)	3.24133221
20	negative regulation of telomere maintenance (GO:0032205)	3.22972953
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22669094
22	NADH dehydrogenase complex assembly (GO:0010257)	3.22669094
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22669094
24	cilium morphogenesis (GO:0060271)	3.19009565
25	pyrimidine nucleobase catabolic process (GO:0006208)	3.17443392
26	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.16063166
27	protein import into peroxisome matrix (GO:0016558)	3.15307381
28	ketone body metabolic process (GO:1902224)	3.10220820
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.05345493
30	cytochrome complex assembly (GO:0017004)	3.05234857
31	epithelial cilium movement (GO:0003351)	3.05074633
32	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.02536099
33	neuronal action potential propagation (GO:0019227)	3.00109844
34	preassembly of GPI anchor in ER membrane (GO:0016254)	2.98692922
35	ubiquinone biosynthetic process (GO:0006744)	2.95454363
36	peptidyl-histidine modification (GO:0018202)	2.95082021
37	C4-dicarboxylate transport (GO:0015740)	2.90055660
38	aggressive behavior (GO:0002118)	2.89816925
39	behavioral response to ethanol (GO:0048149)	2.87867156
40	adult feeding behavior (GO:0008343)	2.82792264
41	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.80596637
42	kidney morphogenesis (GO:0060993)	2.79976147
43	tryptophan catabolic process (GO:0006569)	2.79143476
44	indole-containing compound catabolic process (GO:0042436)	2.79143476
45	indolalkylamine catabolic process (GO:0046218)	2.79143476
46	inner ear receptor cell development (GO:0060119)	2.76939229
47	L-fucose catabolic process (GO:0042355)	2.75911022
48	fucose catabolic process (GO:0019317)	2.75911022
49	L-fucose metabolic process (GO:0042354)	2.75911022
50	photoreceptor cell maintenance (GO:0045494)	2.75383472
51	primary amino compound metabolic process (GO:1901160)	2.75373305
52	kynurenine metabolic process (GO:0070189)	2.72617053
53	ubiquinone metabolic process (GO:0006743)	2.72544543
54	dermatan sulfate biosynthetic process (GO:0030208)	2.70708081
55	retinal ganglion cell axon guidance (GO:0031290)	2.70629997
56	positive regulation of prostaglandin secretion (GO:0032308)	2.68049596
57	lysine metabolic process (GO:0006553)	2.67765037
58	lysine catabolic process (GO:0006554)	2.67765037
59	presynaptic membrane organization (GO:0097090)	2.66919232
60	adenosine metabolic process (GO:0046085)	2.64868151
61	negative regulation of mast cell activation (GO:0033004)	2.64292078
62	sulfation (GO:0051923)	2.57119515
63	positive regulation of fatty acid transport (GO:2000193)	2.56967525
64	axoneme assembly (GO:0035082)	2.56802214
65	detection of light stimulus involved in sensory perception (GO:0050962)	2.55656180
66	detection of light stimulus involved in visual perception (GO:0050908)	2.55656180
67	regulation of neurotransmitter uptake (GO:0051580)	2.53672918
68	indole-containing compound metabolic process (GO:0042430)	2.52332868
69	intraciliary transport (GO:0042073)	2.51936481
70	cilium organization (GO:0044782)	2.51783528
71	appendage development (GO:0048736)	2.51384097
72	limb development (GO:0060173)	2.51384097
73	nucleobase catabolic process (GO:0046113)	2.47130879
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.46980776
75	anterograde synaptic vesicle transport (GO:0048490)	2.46956143
76	cilium assembly (GO:0042384)	2.46177029
77	branched-chain amino acid catabolic process (GO:0009083)	2.45848710
78	indolalkylamine metabolic process (GO:0006586)	2.44807502
79	DNA double-strand break processing (GO:0000729)	2.44394541
80	GPI anchor metabolic process (GO:0006505)	2.44353183
81	intracellular protein transmembrane import (GO:0044743)	2.44209819
82	behavioral defense response (GO:0002209)	2.44145773
83	behavioral fear response (GO:0001662)	2.44145773
84	phosphatidylglycerol biosynthetic process (GO:0006655)	2.44050258
85	protein targeting to peroxisome (GO:0006625)	2.41646689
86	establishment of protein localization to peroxisome (GO:0072663)	2.41646689
87	protein localization to peroxisome (GO:0072662)	2.41646689
88	glycerophospholipid catabolic process (GO:0046475)	2.40813518
89	vascular smooth muscle contraction (GO:0014829)	2.39615925
90	neuron cell-cell adhesion (GO:0007158)	2.38984678
91	smoothened signaling pathway (GO:0007224)	2.38826037
92	lymphangiogenesis (GO:0001946)	2.38778162
93	regulation of microtubule-based movement (GO:0060632)	2.38585340
94	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.37670534
95	artery development (GO:0060840)	2.37105659
96	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.36949689
97	lipopolysaccharide biosynthetic process (GO:0009103)	2.36818460
98	nucleotide transmembrane transport (GO:1901679)	2.35420738
99	peptidyl-cysteine modification (GO:0018198)	2.34694645
100	ATP hydrolysis coupled proton transport (GO:0015991)	2.34359188

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.82048454
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.69212782
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.52355014
4	VDR_22108803_ChIP-Seq_LS180_Human	2.72120349
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.64398233
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.49489316
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42243406
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.20995060
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.19481392
10	P300_19829295_ChIP-Seq_ESCs_Human	2.13458840
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11470383
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.08106756
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03158860
14	FUS_26573619_Chip-Seq_HEK293_Human	1.99297823
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97190156
16	EWS_26573619_Chip-Seq_HEK293_Human	1.93492237
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.83380018
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.79746621
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72368985
20	SMAD4_21799915_ChIP-Seq_A2780_Human	1.72220561
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.71232277
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69501171
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66733214
24	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.65601408
25	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.63770227
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62096065
27	STAT3_23295773_ChIP-Seq_U87_Human	1.59130134
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.56911148
29	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.56423770
30	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.56122152
31	AR_25329375_ChIP-Seq_VCAP_Human	1.55116180
32	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50774805
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49606938
34	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.48703748
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46910863
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.46632320
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46632320
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.45076783
39	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44253672
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.44233426
41	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43989604
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43908246
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41059591
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40726474
45	TCF4_23295773_ChIP-Seq_U87_Human	1.38502060
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.38054620
47	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37464244
48	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.37230838
49	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.34263938
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.32995441
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.29731597
52	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.29411281
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.28666101
54	REST_21632747_ChIP-Seq_MESCs_Mouse	1.28504252
55	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.28168835
56	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26626685
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.26283491
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.25538308
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23068807
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23068807
61	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22280234
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21529037
63	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21529037
64	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.20933098
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.20799006
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18350006
67	* TCF4_22108803_ChIP-Seq_LS180_Human	1.17744134
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.15883281
69	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15505350
70	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14632343
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14472206
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13295445
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12608711
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12435123
75	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12295122
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11911124
77	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.11429569
78	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.11429569
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10206126
80	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10190960
81	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09871006
82	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.09449073
83	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.08548142
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08105314
85	JUN_21703547_ChIP-Seq_K562_Human	1.07757440
86	AR_20517297_ChIP-Seq_VCAP_Human	1.06653396
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06542169
88	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.06128127
89	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.05571522
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05042492
91	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04831975
92	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.03874310
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03106061
94	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.02675371
95	KDM2B_26808549_Chip-Seq_REH_Human	1.02395761
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02381968
97	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02288251
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.01365991
99	NCOR_22424771_ChIP-Seq_293T_Human	1.00903486
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.00579254

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.09045185
2	MP0003880_abnormal_central_pattern	2.72853937
3	MP0003136_yellow_coat_color	2.57283775
4	MP0000569_abnormal_digit_pigmentation	2.55285110
5	MP0002254_reproductive_system_inflammat	2.53113345
6	MP0002638_abnormal_pupillary_reflex	2.43422564
7	MP0002837_dystrophic_cardiac_calcinosis	2.37285033
8	MP0005551_abnormal_eye_electrophysiolog	2.33719401
9	MP0006072_abnormal_retinal_apoptosis	2.29615049
10	MP0002653_abnormal_ependyma_morphology	2.19109243
11	MP0001968_abnormal_touch/_nociception	2.18564159
12	MP0008877_abnormal_DNA_methylation	2.13528764
13	MP0003011_delayed_dark_adaptation	2.09746571
14	MP0005253_abnormal_eye_physiology	2.09714269
15	MP0006276_abnormal_autonomic_nervous	2.04202942
16	MP0002938_white_spotting	1.96299147
17	MP0009046_muscle_twitch	1.93649084
18	MP0003283_abnormal_digestive_organ	1.92641972
19	MP0010386_abnormal_urinary_bladder	1.92277762
20	MP0002736_abnormal_nociception_after	1.90378471
21	MP0005646_abnormal_pituitary_gland	1.83138875
22	MP0004133_heterotaxia	1.79303568
23	MP0009745_abnormal_behavioral_response	1.78573048
24	MP0004885_abnormal_endolymph	1.78451850
25	MP0006292_abnormal_olfactory_placode	1.74396263
26	MP0005171_absent_coat_pigmentation	1.70426134
27	MP0003646_muscle_fatigue	1.68619810
28	MP0002234_abnormal_pharynx_morphology	1.62314191
29	MP0004142_abnormal_muscle_tone	1.60612726
30	MP0005174_abnormal_tail_pigmentation	1.56134424
31	MP0001986_abnormal_taste_sensitivity	1.55793385
32	MP0002064_seizures	1.55360000
33	MP0001486_abnormal_startle_reflex	1.53317600
34	MP0002272_abnormal_nervous_system	1.52668665
35	MP0001984_abnormal_olfaction	1.49384731
36	MP0004147_increased_porphyrin_level	1.48639963
37	MP0005367_renal/urinary_system_phenotyp	1.46834901
38	MP0000516_abnormal_urinary_system	1.46834901
39	MP0008789_abnormal_olfactory_epithelium	1.46184944
40	MP0004043_abnormal_pH_regulation	1.45436098
41	MP0000631_abnormal_neuroendocrine_gland	1.44932538
42	MP0002095_abnormal_skin_pigmentation	1.41377439
43	MP0001485_abnormal_pinna_reflex	1.31820133
44	MP0005645_abnormal_hypothalamus_physiol	1.28269935
45	MP0003195_calcinosis	1.27701412
46	MP0001529_abnormal_vocalization	1.27418223
47	MP0002751_abnormal_autonomic_nervous	1.27307146
48	MP0003787_abnormal_imprinting	1.26059400
49	MP0002572_abnormal_emotion/affect_behav	1.25050722
50	MP0005595_abnormal_vascular_smooth	1.24380232
51	MP0001501_abnormal_sleep_pattern	1.21939552
52	MP0000427_abnormal_hair_cycle	1.18932393
53	MP0000778_abnormal_nervous_system	1.18126205
54	MP0003635_abnormal_synaptic_transmissio	1.17396771
55	MP0002557_abnormal_social/conspecific_i	1.17334913
56	MP0002734_abnormal_mechanical_nocicepti	1.16638272
57	MP0000647_abnormal_sebaceous_gland	1.14339625
58	MP0000383_abnormal_hair_follicle	1.13672167
59	MP0001970_abnormal_pain_threshold	1.09884391
60	MP0005503_abnormal_tendon_morphology	1.07784414
61	MP0004859_abnormal_synaptic_plasticity	1.07274412
62	MP0005379_endocrine/exocrine_gland_phen	1.06605567
63	MP0000230_abnormal_systemic_arterial	1.05301167
64	MP0002876_abnormal_thyroid_physiology	1.03614522
65	MP0003718_maternal_effect	1.03487209
66	MP0002063_abnormal_learning/memory/cond	1.02224139
67	MP0002090_abnormal_vision	1.00197234
68	MP0002163_abnormal_gland_morphology	0.99513512
69	MP0006054_spinal_hemorrhage	0.99095823
70	MP0010368_abnormal_lymphatic_system	0.98818829
71	MP0009250_abnormal_appendicular_skeleto	0.98366835
72	MP0000049_abnormal_middle_ear	0.97046878
73	MP0003279_aneurysm	0.95284871
74	MP0001542_abnormal_bone_strength	0.95237808
75	MP0005499_abnormal_olfactory_system	0.95046034
76	MP0005394_taste/olfaction_phenotype	0.95046034
77	MP0001963_abnormal_hearing_physiology	0.94715681
78	MP0005195_abnormal_posterior_eye	0.94600280
79	MP0000026_abnormal_inner_ear	0.93391176
80	MP0002067_abnormal_sensory_capabilities	0.92895744
81	MP0005391_vision/eye_phenotype	0.90751435
82	MP0001502_abnormal_circadian_rhythm	0.89626588
83	MP0009780_abnormal_chondrocyte_physiolo	0.88921007
84	MP0005167_abnormal_blood-brain_barrier	0.88744673
85	MP0004924_abnormal_behavior	0.88031214
86	MP0005386_behavior/neurological_phenoty	0.88031214
87	MP0002733_abnormal_thermal_nociception	0.86007415
88	MP0003633_abnormal_nervous_system	0.84806378
89	MP0000538_abnormal_urinary_bladder	0.83672473
90	MP0000013_abnormal_adipose_tissue	0.83092549
91	MP0001661_extended_life_span	0.82905864
92	MP0000372_irregular_coat_pigmentation	0.81638488
93	MP0001270_distended_abdomen	0.80306140
94	MP0001293_anophthalmia	0.80188170
95	MP0002752_abnormal_somatic_nervous	0.80071181
96	MP0001764_abnormal_homeostasis	0.79184692
97	MP0003950_abnormal_plasma_membrane	0.79085170
98	MP0008872_abnormal_physiological_respon	0.78894105
99	MP0003119_abnormal_digestive_system	0.78795038
100	MP0003186_abnormal_redox_activity	0.78771165

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.31394190
2	Pancreatic fibrosis (HP:0100732)	4.21962598
3	Abnormality of midbrain morphology (HP:0002418)	4.03473360
4	Molar tooth sign on MRI (HP:0002419)	4.03473360
5	Medial flaring of the eyebrow (HP:0010747)	3.98784735
6	True hermaphroditism (HP:0010459)	3.97449783
7	Nephronophthisis (HP:0000090)	3.66106357
8	Gait imbalance (HP:0002141)	3.42018895
9	Congenital primary aphakia (HP:0007707)	3.35700329
10	Nephrogenic diabetes insipidus (HP:0009806)	3.20277910
11	Hyperventilation (HP:0002883)	3.18516934
12	Abnormality of the renal medulla (HP:0100957)	3.09159825
13	Hemiparesis (HP:0001269)	3.06396170
14	Congenital stationary night blindness (HP:0007642)	2.95837955
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.90264921
16	Abnormality of alanine metabolism (HP:0010916)	2.90264921
17	Hyperalaninemia (HP:0003348)	2.90264921
18	Chronic hepatic failure (HP:0100626)	2.87564032
19	3-Methylglutaconic aciduria (HP:0003535)	2.87193283
20	Abnormality of the renal cortex (HP:0011035)	2.85963112
21	Inability to walk (HP:0002540)	2.75725272
22	Abolished electroretinogram (ERG) (HP:0000550)	2.74794790
23	Abnormal drinking behavior (HP:0030082)	2.74066413
24	Polydipsia (HP:0001959)	2.74066413
25	Tubular atrophy (HP:0000092)	2.70462092
26	Intestinal atresia (HP:0011100)	2.68433859
27	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.65044357
28	Genital tract atresia (HP:0001827)	2.64277547
29	Vaginal atresia (HP:0000148)	2.62428750
30	Large for gestational age (HP:0001520)	2.59474096
31	Attenuation of retinal blood vessels (HP:0007843)	2.59085677
32	Occipital encephalocele (HP:0002085)	2.58846082
33	Abnormal biliary tract physiology (HP:0012439)	2.57796202
34	Bile duct proliferation (HP:0001408)	2.57796202
35	Progressive inability to walk (HP:0002505)	2.55553783
36	Increased corneal curvature (HP:0100692)	2.51596275
37	Keratoconus (HP:0000563)	2.51596275
38	Anencephaly (HP:0002323)	2.51308239
39	Cystic liver disease (HP:0006706)	2.48941850
40	Congenital hepatic fibrosis (HP:0002612)	2.48081799
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.38410963
42	Broad foot (HP:0001769)	2.37470926
43	Short tibia (HP:0005736)	2.33979291
44	Acute necrotizing encephalopathy (HP:0006965)	2.22075315
45	Postaxial foot polydactyly (HP:0001830)	2.21663479
46	Postaxial hand polydactyly (HP:0001162)	2.20878072
47	Renal cortical cysts (HP:0000803)	2.19524404
48	Colon cancer (HP:0003003)	2.19424781
49	Type II lissencephaly (HP:0007260)	2.18835865
50	Sclerocornea (HP:0000647)	2.17832856
51	Mitochondrial inheritance (HP:0001427)	2.16364276
52	Methylmalonic acidemia (HP:0002912)	2.14511143
53	Polyuria (HP:0000103)	2.11560093
54	Poor coordination (HP:0002370)	2.11462820
55	Congenital sensorineural hearing impairment (HP:0008527)	2.07888411
56	Hepatocellular necrosis (HP:0001404)	2.07054793
57	Poor head control (HP:0002421)	2.05498759
58	Optic nerve hypoplasia (HP:0000609)	2.03432013
59	Focal seizures (HP:0007359)	2.03308259
60	Polyphagia (HP:0002591)	2.03167329
61	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.01723982
62	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.99824687
63	Acute encephalopathy (HP:0006846)	1.99310930
64	Gaze-evoked nystagmus (HP:0000640)	1.99148254
65	Methylmalonic aciduria (HP:0012120)	1.98722427
66	Mesangial abnormality (HP:0001966)	1.98524816
67	Hepatic necrosis (HP:0002605)	1.98497624
68	Hemiplegia (HP:0002301)	1.97833387
69	Aplasia/Hypoplasia of the lens (HP:0008063)	1.97440262
70	Abnormality of the labia minora (HP:0012880)	1.97155840
71	Progressive macrocephaly (HP:0004481)	1.92537554
72	Specific learning disability (HP:0001328)	1.91822308
73	Disproportionate short-trunk short stature (HP:0003521)	1.91188966
74	Increased CSF lactate (HP:0002490)	1.88211781
75	Ketoacidosis (HP:0001993)	1.85751788
76	Focal motor seizures (HP:0011153)	1.85630657
77	Pendular nystagmus (HP:0012043)	1.83812060
78	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82024992
79	Retinal dysplasia (HP:0007973)	1.80395346
80	Gastrointestinal atresia (HP:0002589)	1.79568621
81	Hypoplasia of the fovea (HP:0007750)	1.77545355
82	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.77545355
83	Hyperglycinemia (HP:0002154)	1.76754640
84	Progressive microcephaly (HP:0000253)	1.76101912
85	Abnormal rod and cone electroretinograms (HP:0008323)	1.74657766
86	Congenital, generalized hypertrichosis (HP:0004540)	1.72696637
87	Preaxial hand polydactyly (HP:0001177)	1.72175981
88	Constricted visual fields (HP:0001133)	1.72048319
89	Short foot (HP:0001773)	1.71788742
90	Furrowed tongue (HP:0000221)	1.70760436
91	Optic disc pallor (HP:0000543)	1.70616779
92	Absent speech (HP:0001344)	1.70549418
93	Broad metatarsal (HP:0001783)	1.68168689
94	Hypomagnesemia (HP:0002917)	1.67882199
95	Cerebellar dysplasia (HP:0007033)	1.67193664
96	Dandy-Walker malformation (HP:0001305)	1.67008398
97	Aganglionic megacolon (HP:0002251)	1.66340080
98	Short hallux (HP:0010109)	1.64843914
99	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.63564983
100	Generalized tonic-clonic seizures (HP:0002069)	1.63256855

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.33807570
2	MAP4K2	3.92872281
3	ADRBK2	2.69622370
4	BMPR1B	2.46669572
5	WNK3	2.27693172
6	ACVR1B	2.13854984
7	GRK1	1.93915400
8	PINK1	1.90014721
9	CASK	1.88499541
10	ZAK	1.88425272
11	NUAK1	1.87278094
12	BCKDK	1.81139737
13	INSRR	1.75929188
14	TIE1	1.65151153
15	LIMK1	1.65032312
16	TLK1	1.63501085
17	MAP3K4	1.61505971
18	DAPK2	1.58908878
19	CDK19	1.54437461
20	WNK4	1.52377515
21	PLK2	1.51689965
22	TNIK	1.48519892
23	FLT3	1.44580100
24	MUSK	1.36591315
25	VRK2	1.33704026
26	MARK1	1.31976567
27	MAPK13	1.30255070
28	ADRBK1	1.26585301
29	TGFBR1	1.24968770
30	NTRK2	1.23388309
31	EPHA4	1.22628669
32	OXSR1	1.21717121
33	NTRK3	1.19818332
34	PAK3	1.18968470
35	PAK6	1.16946180
36	DYRK2	1.15072460
37	CSNK1G2	1.15058712
38	CAMKK2	1.12562686
39	VRK1	1.09877268
40	PRKCE	1.07209800
41	CSNK1G3	1.06292913
42	TAOK3	1.03889565
43	PRKCG	0.98305202
44	CSNK1G1	0.97019800
45	PRKD3	0.95479918
46	GRK7	0.93720651
47	PKN1	0.92727359
48	PTK2B	0.87215399
49	CAMK1	0.86238041
50	CSNK1A1L	0.84196815
51	EPHB2	0.81507354
52	BRSK2	0.81408808
53	STK39	0.81230796
54	PASK	0.80838964
55	MAP2K7	0.80622151
56	PHKG1	0.77299535
57	PHKG2	0.77299535
58	PLK3	0.76947809
59	CAMK1G	0.73976971
60	PNCK	0.73046489
61	STK38L	0.71208215
62	PLK4	0.70973118
63	CAMK2A	0.68484046
64	KIT	0.67820168
65	PIK3CA	0.67682910
66	CCNB1	0.65523524
67	FGFR2	0.64349711
68	MKNK2	0.55587213
69	CDK3	0.54885180
70	CAMK1D	0.53099510
71	MKNK1	0.52472329
72	MYLK	0.52384956
73	ERBB3	0.51597340
74	SGK223	0.46905519
75	SGK494	0.46905519
76	OBSCN	0.45405541
77	SGK2	0.44583955
78	MAPKAPK5	0.43986437
79	CDK5	0.41419563
80	ROCK1	0.40451729
81	PRKACA	0.39932827
82	CSNK1A1	0.38974402
83	PDK2	0.38495472
84	RPS6KA5	0.37342123
85	CAMK2D	0.36414600
86	PRKCA	0.35597475
87	NLK	0.35596396
88	STK11	0.32742751
89	KDR	0.32716164
90	DDR2	0.31377570
91	CDK9	0.31251811
92	TXK	0.30904880
93	DYRK1A	0.30799854
94	PRKCQ	0.29458533
95	PRKG1	0.29254025
96	IRAK1	0.28702186
97	MAP2K6	0.27245076
98	GRK5	0.26609342
99	PLK1	0.26082569
100	ABL1	0.25587296

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.30758975
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.67324808
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.55796813
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.43948494
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.41268668
6	Butanoate metabolism_Homo sapiens_hsa00650	2.16868778
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.09433804
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.09412267
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.08033154
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.02465245
11	Collecting duct acid secretion_Homo sapiens_hsa04966	1.99950000
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.97437350
13	Nicotine addiction_Homo sapiens_hsa05033	1.90631425
14	Parkinsons disease_Homo sapiens_hsa05012	1.82320758
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.81645678
16	Phototransduction_Homo sapiens_hsa04744	1.77915026
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.75261136
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.73090883
19	Peroxisome_Homo sapiens_hsa04146	1.72364259
20	One carbon pool by folate_Homo sapiens_hsa00670	1.70732808
21	Propanoate metabolism_Homo sapiens_hsa00640	1.70107116
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.66229061
23	RNA polymerase_Homo sapiens_hsa03020	1.64642368
24	Protein export_Homo sapiens_hsa03060	1.60200162
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59205549
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56009055
27	Sulfur metabolism_Homo sapiens_hsa00920	1.49409442
28	Regulation of autophagy_Homo sapiens_hsa04140	1.41938660
29	Homologous recombination_Homo sapiens_hsa03440	1.40381809
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.34009288
31	GABAergic synapse_Homo sapiens_hsa04727	1.33678845
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30945463
33	Huntingtons disease_Homo sapiens_hsa05016	1.29441429
34	Morphine addiction_Homo sapiens_hsa05032	1.28993017
35	Alzheimers disease_Homo sapiens_hsa05010	1.25605110
36	Taste transduction_Homo sapiens_hsa04742	1.22883382
37	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21855488
38	Basal transcription factors_Homo sapiens_hsa03022	1.20421468
39	Insulin secretion_Homo sapiens_hsa04911	1.19881143
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.12729078
41	RNA degradation_Homo sapiens_hsa03018	1.11083951
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.06873962
43	Circadian entrainment_Homo sapiens_hsa04713	1.04608273
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.04041434
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.03801925
46	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01316861
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.00747878
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99436661
49	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99381151
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.98600374
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.98577634
52	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.94009556
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88358434
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.86472582
55	Olfactory transduction_Homo sapiens_hsa04740	0.86214218
56	Sulfur relay system_Homo sapiens_hsa04122	0.85052634
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81292895
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.79725681
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.79194716
60	Metabolic pathways_Homo sapiens_hsa01100	0.77178681
61	Proteasome_Homo sapiens_hsa03050	0.76919834
62	Fatty acid elongation_Homo sapiens_hsa00062	0.76890248
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75649009
64	Caffeine metabolism_Homo sapiens_hsa00232	0.74500350
65	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73547142
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.72607923
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.71235283
68	Salivary secretion_Homo sapiens_hsa04970	0.70229403
69	Folate biosynthesis_Homo sapiens_hsa00790	0.69411596
70	Lysosome_Homo sapiens_hsa04142	0.69109796
71	Serotonergic synapse_Homo sapiens_hsa04726	0.67400749
72	Purine metabolism_Homo sapiens_hsa00230	0.63949168
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61726905
74	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58338339
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.58300469
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55747730
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.55062824
78	Glutathione metabolism_Homo sapiens_hsa00480	0.53453786
79	Dopaminergic synapse_Homo sapiens_hsa04728	0.53385940
80	Mineral absorption_Homo sapiens_hsa04978	0.53116844
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.52130946
82	Basal cell carcinoma_Homo sapiens_hsa05217	0.50013296
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49698149
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.49439898
85	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48845680
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48138437
87	Long-term depression_Homo sapiens_hsa04730	0.47464152
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45709873
89	Fatty acid degradation_Homo sapiens_hsa00071	0.45702716
90	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45647044
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.44089603
92	Fatty acid metabolism_Homo sapiens_hsa01212	0.43181084
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42779669
94	Retinol metabolism_Homo sapiens_hsa00830	0.42745154
95	Base excision repair_Homo sapiens_hsa03410	0.42638967
96	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.40780656
97	Cocaine addiction_Homo sapiens_hsa05030	0.38445127
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38028358
99	Histidine metabolism_Homo sapiens_hsa00340	0.34038335
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32788477

C16ORF62

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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