ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.49915874
2	L-phenylalanine catabolic process (GO:0006559)	5.49915874
3	negative regulation of fibrinolysis (GO:0051918)	5.20365337
4	cholesterol efflux (GO:0033344)	5.03839728
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.99121955
6	L-phenylalanine metabolic process (GO:0006558)	4.99121955
7	regulation of fibrinolysis (GO:0051917)	4.95968374
8	aromatic amino acid family catabolic process (GO:0009074)	4.43355719
9	plasma lipoprotein particle assembly (GO:0034377)	4.43188549
10	very-low-density lipoprotein particle assembly (GO:0034379)	4.36352453
11	protein carboxylation (GO:0018214)	4.33189020
12	peptidyl-glutamic acid carboxylation (GO:0017187)	4.33189020
13	intestinal cholesterol absorption (GO:0030299)	4.32028995
14	regulation of protein activation cascade (GO:2000257)	4.17358517
15	piRNA metabolic process (GO:0034587)	4.13023650
16	low-density lipoprotein particle remodeling (GO:0034374)	4.03353696
17	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.99925161
18	regulation of complement activation (GO:0030449)	3.98611885
19	protein-lipid complex assembly (GO:0065005)	3.96708787
20	protein-lipid complex remodeling (GO:0034368)	3.86324813
21	macromolecular complex remodeling (GO:0034367)	3.86324813
22	plasma lipoprotein particle remodeling (GO:0034369)	3.86324813
23	high-density lipoprotein particle remodeling (GO:0034375)	3.81575171
24	complement activation, alternative pathway (GO:0006957)	3.70751737
25	regulation of cholesterol esterification (GO:0010872)	3.64031973
26	plasma lipoprotein particle organization (GO:0071827)	3.61410324
27	phospholipid efflux (GO:0033700)	3.60570654
28	reverse cholesterol transport (GO:0043691)	3.59665191
29	plasma lipoprotein particle clearance (GO:0034381)	3.50871896
30	glycerophospholipid catabolic process (GO:0046475)	3.50432601
31	indole-containing compound catabolic process (GO:0042436)	3.48635582
32	indolalkylamine catabolic process (GO:0046218)	3.48635582
33	tryptophan catabolic process (GO:0006569)	3.48635582
34	kynurenine metabolic process (GO:0070189)	3.44151604
35	C4-dicarboxylate transport (GO:0015740)	3.44043624
36	negative regulation of protein activation cascade (GO:2000258)	3.42017048
37	negative regulation of cholesterol transport (GO:0032375)	3.41417066
38	negative regulation of sterol transport (GO:0032372)	3.41417066
39	protein-lipid complex subunit organization (GO:0071825)	3.41013983
40	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.40625788
41	diacylglycerol metabolic process (GO:0046339)	3.37653683
42	DNA methylation involved in gamete generation (GO:0043046)	3.32160850
43	tryptophan metabolic process (GO:0006568)	3.30507746
44	aromatic amino acid family metabolic process (GO:0009072)	3.30448927
45	sodium-independent organic anion transport (GO:0043252)	3.25366971
46	blood coagulation, intrinsic pathway (GO:0007597)	3.24512588
47	protein-cofactor linkage (GO:0018065)	3.24021363
48	phosphate ion transmembrane transport (GO:0035435)	3.23602035
49	bile acid biosynthetic process (GO:0006699)	3.23497814
50	basic amino acid transport (GO:0015802)	3.22481377
51	adaptation of signaling pathway (GO:0023058)	3.19914828
52	exogenous drug catabolic process (GO:0042738)	3.18527027
53	indolalkylamine metabolic process (GO:0006586)	3.17198636
54	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.16104155
55	sterol transport (GO:0015918)	3.13522745
56	cholesterol transport (GO:0030301)	3.13522745
57	acylglycerol homeostasis (GO:0055090)	3.10406861
58	triglyceride homeostasis (GO:0070328)	3.10406861
59	cellular ketone body metabolic process (GO:0046950)	3.09930079
60	heme transport (GO:0015886)	3.09910076
61	negative regulation of digestive system process (GO:0060457)	3.06273438
62	imidazole-containing compound metabolic process (GO:0052803)	3.02755129
63	transepithelial transport (GO:0070633)	3.02540587
64	cellular biogenic amine catabolic process (GO:0042402)	3.01759559
65	amine catabolic process (GO:0009310)	3.01759559
66	tyrosine metabolic process (GO:0006570)	3.00878960
67	folic acid transport (GO:0015884)	2.98025261
68	serine family amino acid catabolic process (GO:0009071)	2.96710298
69	S-adenosylmethionine metabolic process (GO:0046500)	2.95466422
70	fibrinolysis (GO:0042730)	2.95022647
71	peptidyl-glutamic acid modification (GO:0018200)	2.93578614
72	phosphate ion transport (GO:0006817)	2.92414595
73	acute-phase response (GO:0006953)	2.91286222
74	glutamate metabolic process (GO:0006536)	2.89504882
75	drug catabolic process (GO:0042737)	2.87347497
76	positive regulation of lipoprotein lipase activity (GO:0051006)	2.85804275
77	positive regulation of triglyceride lipase activity (GO:0061365)	2.85804275
78	alpha-amino acid catabolic process (GO:1901606)	2.84407594
79	galactose catabolic process (GO:0019388)	2.83973723
80	regulation of plasminogen activation (GO:0010755)	2.83579449
81	regulation of apoptotic cell clearance (GO:2000425)	2.81709983
82	negative regulation of complement activation (GO:0045916)	2.80672184
83	oligosaccharide catabolic process (GO:0009313)	2.78943178
84	bile acid metabolic process (GO:0008206)	2.76939955
85	galactose metabolic process (GO:0006012)	2.72701807
86	vitamin transmembrane transport (GO:0035461)	2.72146880
87	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.69621052
88	lipoprotein metabolic process (GO:0042157)	2.69557882
89	oxidative demethylation (GO:0070989)	2.68584998
90	cholesterol homeostasis (GO:0042632)	2.68125973
91	sterol homeostasis (GO:0055092)	2.65827307
92	epoxygenase P450 pathway (GO:0019373)	2.64941983
93	intestinal absorption (GO:0050892)	2.63955989
94	ketone body metabolic process (GO:1902224)	2.63225569
95	detection of light stimulus involved in sensory perception (GO:0050962)	2.61708616
96	detection of light stimulus involved in visual perception (GO:0050908)	2.61708616
97	cellular amino acid catabolic process (GO:0009063)	2.61256549
98	negative regulation of lipase activity (GO:0060192)	2.60242751
99	regulation of humoral immune response (GO:0002920)	2.58662612
100	positive regulation of blood coagulation (GO:0030194)	2.55619929

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.76541984
2	* ZNF274_21170338_ChIP-Seq_K562_Hela	4.12900383
3	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.78299704
4	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.64446752
5	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.30498301
6	VDR_22108803_ChIP-Seq_LS180_Human	2.99710059
7	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.85189573
8	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.58677097
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57959878
10	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.57030299
11	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.48914062
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42428205
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.25536326
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.16847589
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.07706466
16	* HNF4A_19822575_ChIP-Seq_HepG2_Human	2.07253202
17	* FOXA2_19822575_ChIP-Seq_HepG2_Human	2.03329150
18	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.84478557
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.77867634
20	OCT4_20526341_ChIP-Seq_ESCs_Human	1.70677603
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.64870862
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.63022238
23	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.52996231
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.48659556
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.46204589
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.42357144
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41672812
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41565405
29	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.41095051
30	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.39576455
31	AR_20517297_ChIP-Seq_VCAP_Human	1.37153348
32	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.35596064
33	MYC_19829295_ChIP-Seq_ESCs_Human	1.35519486
34	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35367609
35	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35367609
36	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.34332163
37	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.34259764
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.34244156
39	ERA_21632823_ChIP-Seq_H3396_Human	1.33406906
40	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.32861997
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.32412493
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28002651
43	HOXB7_26014856_ChIP-Seq_BT474_Human	1.27147140
44	TP53_22573176_ChIP-Seq_HFKS_Human	1.27064839
45	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26229770
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24330559
47	NCOR_22424771_ChIP-Seq_293T_Human	1.23456099
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23257091
49	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21492585
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.21350220
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.19720734
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19653519
53	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.19635493
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.18463632
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17793944
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17793944
57	GATA3_26560356_Chip-Seq_TH2_Human	1.17263849
58	AR_21572438_ChIP-Seq_LNCaP_Human	1.16773498
59	STAT3_23295773_ChIP-Seq_U87_Human	1.11451291
60	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11393549
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11175453
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10734318
63	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09821360
64	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.06809744
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.05400404
66	P300_19829295_ChIP-Seq_ESCs_Human	1.05248373
67	TCF4_23295773_ChIP-Seq_U87_Human	1.04340314
68	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.04167541
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03864972
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01178473
71	GATA4_25053715_ChIP-Seq_YYC3_Human	1.00476202
72	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99410396
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.96388101
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.96185752
75	AR_25329375_ChIP-Seq_VCAP_Human	0.95987246
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95714233
77	TAF15_26573619_Chip-Seq_HEK293_Human	0.94969137
78	CDX2_22108803_ChIP-Seq_LS180_Human	0.94557119
79	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.92575801
80	IRF8_27001747_Chip-Seq_BMDM_Mouse	0.90470756
81	TCF4_22108803_ChIP-Seq_LS180_Human	0.89660596
82	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.88807087
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.87380691
84	* SMAD4_21741376_ChIP-Seq_EPCs_Human	0.87226386
85	* GABP_19822575_ChIP-Seq_HepG2_Human	0.86743619
86	* GATA3_26560356_Chip-Seq_TH1_Human	0.86496009
87	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.86441293
88	CEBPB_22108803_ChIP-Seq_LS180_Human	0.85710510
89	VDR_24787735_ChIP-Seq_THP-1_Human	0.85489016
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.84941441
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.83414485
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83299087
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82866631
94	TP53_16413492_ChIP-PET_HCT116_Human	0.82861773
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.82800307
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.82758424
97	BCOR_27268052_Chip-Seq_Bcells_Human	0.82725891
98	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.80992628
99	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.80924514
100	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.80830248

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.58606947
2	MP0003195_calcinosis	5.38534767
3	MP0005365_abnormal_bile_salt	4.03803709
4	MP0005360_urolithiasis	3.92708577
5	MP0008875_abnormal_xenobiotic_pharmacok	3.34017429
6	MP0003122_maternal_imprinting	3.14773122
7	MP0005085_abnormal_gallbladder_physiolo	3.01602866
8	MP0003172_abnormal_lysosome_physiology	2.77340410
9	MP0010329_abnormal_lipoprotein_level	2.57746349
10	MP0009840_abnormal_foam_cell	2.43781054
11	MP0005058_abnormal_lysosome_morphology	2.38359892
12	MP0001986_abnormal_taste_sensitivity	2.18604952
13	MP0003252_abnormal_bile_duct	2.10934547
14	MP0001764_abnormal_homeostasis	2.02678226
15	MP0008877_abnormal_DNA_methylation	2.01766987
16	MP0003646_muscle_fatigue	1.89937929
17	MP0005332_abnormal_amino_acid	1.87710496
18	MP0005167_abnormal_blood-brain_barrier	1.82802914
19	MP0008260_abnormal_autophagy	1.67229860
20	MP0001666_abnormal_nutrient_absorption	1.66830448
21	MP0000372_irregular_coat_pigmentation	1.63530982
22	MP0002132_abnormal_respiratory_system	1.55158877
23	MP0005551_abnormal_eye_electrophysiolog	1.49519700
24	MP0003011_delayed_dark_adaptation	1.44715330
25	MP0009046_muscle_twitch	1.43050777
26	MP0005084_abnormal_gallbladder_morpholo	1.42521929
27	MP0002118_abnormal_lipid_homeostasis	1.41623813
28	MP0003191_abnormal_cellular_cholesterol	1.40385106
29	MP0006082_CNS_inflammation	1.34800647
30	MP0003878_abnormal_ear_physiology	1.34540457
31	MP0005377_hearing/vestibular/ear_phenot	1.34540457
32	MP0003879_abnormal_hair_cell	1.33139210
33	MP0002138_abnormal_hepatobiliary_system	1.28603043
34	MP0000609_abnormal_liver_physiology	1.16915775
35	MP0001501_abnormal_sleep_pattern	1.15968444
36	MP0003950_abnormal_plasma_membrane	1.13503578
37	MP0003718_maternal_effect	1.08379206
38	MP0000604_amyloidosis	1.07372804
39	MP0005410_abnormal_fertilization	1.06509227
40	MP0002876_abnormal_thyroid_physiology	1.06436699
41	MP0010386_abnormal_urinary_bladder	1.06416151
42	MP0003121_genomic_imprinting	1.03215359
43	MP0002148_abnormal_hypersensitivity_rea	1.02023259
44	MP0002653_abnormal_ependyma_morphology	0.99778071
45	MP0005464_abnormal_platelet_physiology	0.99659213
46	MP0003303_peritoneal_inflammation	0.97901133
47	MP0003633_abnormal_nervous_system	0.97513569
48	MP0005636_abnormal_mineral_homeostasis	0.97368827
49	MP0004142_abnormal_muscle_tone	0.96994343
50	MP0003136_yellow_coat_color	0.96766095
51	MP0005646_abnormal_pituitary_gland	0.96661664
52	MP0008469_abnormal_protein_level	0.96524732
53	MP0009764_decreased_sensitivity_to	0.94746064
54	MP0001324_abnormal_eye_pigmentation	0.93839442
55	MP0003806_abnormal_nucleotide_metabolis	0.93168770
56	MP0003183_abnormal_peptide_metabolism	0.92405454
57	MP0004043_abnormal_pH_regulation	0.88881617
58	MP0003436_decreased_susceptibility_to	0.87784657
59	MP0006035_abnormal_mitochondrial_morpho	0.86572668
60	MP0002837_dystrophic_cardiac_calcinosis	0.86327929
61	MP0009785_altered_susceptibility_to	0.86317477
62	MP0001984_abnormal_olfaction	0.84202060
63	MP0002419_abnormal_innate_immunity	0.83917956
64	MP0005451_abnormal_body_composition	0.83602615
65	MP0009745_abnormal_behavioral_response	0.81154945
66	MP0000371_diluted_coat_color	0.81060958
67	MP0002064_seizures	0.79965293
68	MP0003787_abnormal_imprinting	0.79938305
69	MP0004019_abnormal_vitamin_homeostasis	0.79745297
70	MP0001502_abnormal_circadian_rhythm	0.79289971
71	MP0002229_neurodegeneration	0.79231433
72	MP0003656_abnormal_erythrocyte_physiolo	0.78181706
73	MP0002102_abnormal_ear_morphology	0.76368228
74	MP0005408_hypopigmentation	0.76184510
75	MP0005448_abnormal_energy_balance	0.74661357
76	MP0009780_abnormal_chondrocyte_physiolo	0.74647588
77	MP0005584_abnormal_enzyme/coenzyme_acti	0.74407396
78	MP0004742_abnormal_vestibular_system	0.73342897
79	MP0000598_abnormal_liver_morphology	0.72814845
80	MP0001968_abnormal_touch/_nociception	0.72655124
81	MP0001661_extended_life_span	0.72287330
82	MP0009642_abnormal_blood_homeostasis	0.72213903
83	MP0005319_abnormal_enzyme/_coenzyme	0.71399189
84	MP0003868_abnormal_feces_composition	0.70778720
85	MP0002078_abnormal_glucose_homeostasis	0.70247066
86	MP0002971_abnormal_brown_adipose	0.69390679
87	MP0001486_abnormal_startle_reflex	0.67803272
88	MP0002272_abnormal_nervous_system	0.67479027
89	MP0003698_abnormal_male_reproductive	0.67083407
90	MP0005253_abnormal_eye_physiology	0.66973305
91	MP0001929_abnormal_gametogenesis	0.66504054
92	MP0003631_nervous_system_phenotype	0.66117415
93	MP0005376_homeostasis/metabolism_phenot	0.66045976
94	MP0000920_abnormal_myelination	0.66031084
95	MP0005395_other_phenotype	0.64586925
96	MP0000427_abnormal_hair_cycle	0.63439681
97	MP0002572_abnormal_emotion/affect_behav	0.62005953
98	MP0002557_abnormal_social/conspecific_i	0.61467482
99	MP0001915_intracranial_hemorrhage	0.60775126
100	MP0004924_abnormal_behavior	0.60455652

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	5.55029562
2	Prolonged partial thromboplastin time (HP:0003645)	5.48768966
3	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.70297159
4	Hypobetalipoproteinemia (HP:0003563)	4.01887639
5	Joint hemorrhage (HP:0005261)	3.86710995
6	Vacuolated lymphocytes (HP:0001922)	3.70956347
7	Complement deficiency (HP:0004431)	3.46462964
8	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.30269282
9	Glomerulonephritis (HP:0000099)	2.99630584
10	Systemic lupus erythematosus (HP:0002725)	2.99592433
11	Abnormality of liposaccharide metabolism (HP:0010968)	2.89533952
12	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.89533952
13	Abnormality of glycolipid metabolism (HP:0010969)	2.89533952
14	Increased cerebral lipofuscin (HP:0011813)	2.82229602
15	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.79154798
16	Xanthomatosis (HP:0000991)	2.77101224
17	Epidermoid cyst (HP:0200040)	2.76711401
18	Abnormality of the common coagulation pathway (HP:0010990)	2.75718214
19	Acanthocytosis (HP:0001927)	2.74402255
20	Abnormality of the pubic bones (HP:0003172)	2.71619586
21	Spontaneous abortion (HP:0005268)	2.66962610
22	Abnormality of polysaccharide metabolism (HP:0011012)	2.63067894
23	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.63067894
24	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.63067894
25	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.60641670
26	Pendular nystagmus (HP:0012043)	2.57004957
27	Retinal atrophy (HP:0001105)	2.52801881
28	Mutism (HP:0002300)	2.50095122
29	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.50042952
30	Abnormality of the wing of the ilium (HP:0011867)	2.49394988
31	Conjugated hyperbilirubinemia (HP:0002908)	2.47499482
32	Disproportionate short-trunk short stature (HP:0003521)	2.43533834
33	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.38997346
34	Abnormality of alanine metabolism (HP:0010916)	2.38997346
35	Hyperalaninemia (HP:0003348)	2.38997346
36	Mucopolysacchariduria (HP:0008155)	2.38158913
37	Urinary glycosaminoglycan excretion (HP:0003541)	2.38158913
38	Intrahepatic cholestasis (HP:0001406)	2.36819921
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.33617602
40	Hypothermia (HP:0002045)	2.33238317
41	Fibular aplasia (HP:0002990)	2.32440911
42	Ketosis (HP:0001946)	2.25841745
43	Metaphyseal irregularity (HP:0003025)	2.22518760
44	Azoospermia (HP:0000027)	2.19694365
45	Barrel-shaped chest (HP:0001552)	2.18469133
46	Optic neuritis (HP:0100653)	2.11713456
47	Retrobulbar optic neuritis (HP:0100654)	2.11713456
48	Oligodactyly (hands) (HP:0001180)	2.11247909
49	Purpura (HP:0000979)	2.09976096
50	Hypolipoproteinemia (HP:0010981)	2.08938940
51	Hypoplastic iliac wings (HP:0002866)	2.08327563
52	Abnormality of the labia minora (HP:0012880)	2.05055143
53	Generalized aminoaciduria (HP:0002909)	2.04783982
54	Abnormality of complement system (HP:0005339)	2.03834144
55	Synostosis involving the elbow (HP:0003938)	2.02104376
56	Humeroradial synostosis (HP:0003041)	2.02104376
57	Ketoacidosis (HP:0001993)	2.01330880
58	Stomatitis (HP:0010280)	2.00445882
59	Hypoglycemic coma (HP:0001325)	2.00349217
60	Gingival bleeding (HP:0000225)	2.00243487
61	Disinhibition (HP:0000734)	1.99640577
62	Chronic hepatic failure (HP:0100626)	1.98692442
63	Abolished electroretinogram (ERG) (HP:0000550)	1.95993409
64	Abnormal biliary tract physiology (HP:0012439)	1.95393836
65	Bile duct proliferation (HP:0001408)	1.95393836
66	Pancreatic islet-cell hyperplasia (HP:0004510)	1.94195837
67	Hyperglycinemia (HP:0002154)	1.93400276
68	Lissencephaly (HP:0001339)	1.92244033
69	Agitation (HP:0000713)	1.86743378
70	Hemorrhage of the eye (HP:0011885)	1.86226603
71	Hypercholesterolemia (HP:0003124)	1.85458864
72	Type II lissencephaly (HP:0007260)	1.83797717
73	Dysostosis multiplex (HP:0000943)	1.82791571
74	Fat malabsorption (HP:0002630)	1.81950487
75	Skin nodule (HP:0200036)	1.81496857
76	Prolonged neonatal jaundice (HP:0006579)	1.80742902
77	Episodic fever (HP:0001954)	1.80620784
78	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.80271473
79	Abnormal protein N-linked glycosylation (HP:0012347)	1.80271473
80	Abnormal protein glycosylation (HP:0012346)	1.80271473
81	Abnormal glycosylation (HP:0012345)	1.80271473
82	Mesangial abnormality (HP:0001966)	1.80108631
83	Type I transferrin isoform profile (HP:0003642)	1.79296665
84	Loss of speech (HP:0002371)	1.76735413
85	Hypoplasia of the odontoid process (HP:0003311)	1.75014501
86	Orchitis (HP:0100796)	1.73454530
87	Febrile seizures (HP:0002373)	1.73438910
88	Abnormality of transition element cation homeostasis (HP:0011030)	1.72967984
89	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72434134
90	Enlarged kidneys (HP:0000105)	1.71968855
91	Beaking of vertebral bodies (HP:0004568)	1.71613442
92	Abnormality of dental color (HP:0011073)	1.70839205
93	Recurrent gram-negative bacterial infections (HP:0005420)	1.68814739
94	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.67945046
95	Medial flaring of the eyebrow (HP:0010747)	1.67678566
96	Abnormality of endocrine pancreas physiology (HP:0012093)	1.65536464
97	Abnormality of the pancreatic islet cells (HP:0006476)	1.65536464
98	Gangrene (HP:0100758)	1.64544387
99	CNS demyelination (HP:0007305)	1.64102630
100	Spastic tetraplegia (HP:0002510)	1.63743356

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.33857668
2	PDK2	3.27342553
3	WNK4	2.67732613
4	WNK3	2.44999120
5	TAOK3	2.18081533
6	ADRBK2	2.09761101
7	TRIM28	2.05508080
8	MAP4K2	1.99055068
9	MAP2K6	1.90162785
10	SIK2	1.88686373
11	FGFR4	1.81195919
12	PINK1	1.79957568
13	ACVR1B	1.77394994
14	AKT3	1.75830214
15	EIF2AK3	1.72224410
16	NUAK1	1.72138193
17	CASK	1.68969104
18	FGFR3	1.64561686
19	INSRR	1.59274947
20	TNK2	1.57896782
21	SIK3	1.54597040
22	CAMK1D	1.51906945
23	ZAK	1.47399245
24	PAK3	1.46715311
25	OXSR1	1.42748336
26	DAPK2	1.41733645
27	PRKCG	1.41703078
28	MAPK13	1.41408003
29	FGR	1.40044423
30	GRK1	1.39580086
31	FER	1.37382060
32	EPHA3	1.35075706
33	PDPK1	1.34195321
34	MATK	1.25240215
35	PRKCE	1.24312989
36	PRKCZ	1.23498630
37	IKBKB	1.17451176
38	NTRK3	1.16359570
39	MAP3K5	1.12624784
40	BCKDK	1.11574466
41	STK39	1.10257906
42	MAP3K4	1.08106070
43	CAMKK2	1.07466180
44	PRKAA2	1.07185918
45	PDK1	1.03277255
46	PIK3CA	0.97543725
47	BRD4	0.95827661
48	MAP3K11	0.95462509
49	PKN1	0.93066934
50	PRKCI	0.92972001
51	CAMK1G	0.91619716
52	TYRO3	0.88082970
53	MAPKAPK3	0.84879409
54	TXK	0.83591847
55	EPHA4	0.83097453
56	MAP2K4	0.82019505
57	PRKAA1	0.79293594
58	MARK3	0.77081459
59	BMPR1B	0.75045375
60	ERBB2	0.70615480
61	CDK12	0.70521062
62	IRAK1	0.69839252
63	TAOK1	0.67709156
64	PRKCQ	0.65417543
65	MARK1	0.65161857
66	STK38	0.63179717
67	TBK1	0.63125738
68	STK38L	0.59685234
69	TGFBR2	0.58294181
70	CHUK	0.58249632
71	IRAK3	0.55784905
72	PRKD3	0.55389540
73	MAPK11	0.55327312
74	BCR	0.53807748
75	PRKD2	0.50088956
76	SYK	0.47996662
77	PRKACG	0.46837958
78	CSF1R	0.46680649
79	CAMK4	0.45995193
80	MAP3K6	0.45072609
81	MAP4K1	0.43935466
82	SGK1	0.43659484
83	MAP2K3	0.43628363
84	BLK	0.42948276
85	SGK2	0.41257637
86	CSNK1A1	0.40255390
87	CDC42BPA	0.40228788
88	IGF1R	0.38904157
89	LATS1	0.38506264
90	PHKG1	0.38071841
91	PHKG2	0.38071841
92	PRKG1	0.37149926
93	CSNK1A1L	0.36541676
94	BMPR2	0.35305093
95	TEC	0.33748471
96	RET	0.33473746
97	SGK494	0.33254504
98	SGK223	0.33254504
99	FGFR1	0.32592290
100	PRKACA	0.32054849

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.15519096
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.78870423
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.57922088
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.40021689
5	Butanoate metabolism_Homo sapiens_hsa00650	2.39925335
6	Fatty acid degradation_Homo sapiens_hsa00071	2.10390847
7	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.08993639
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.02273438
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.98075907
10	Caffeine metabolism_Homo sapiens_hsa00232	1.96478770
11	Steroid biosynthesis_Homo sapiens_hsa00100	1.86693151
12	Other glycan degradation_Homo sapiens_hsa00511	1.86321200
13	Tryptophan metabolism_Homo sapiens_hsa00380	1.86157449
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.85841898
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.78456392
16	Lysosome_Homo sapiens_hsa04142	1.74985118
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.69457160
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.68976188
19	Fatty acid metabolism_Homo sapiens_hsa01212	1.67768412
20	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.63941820
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.63518811
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.63287619
23	Retinol metabolism_Homo sapiens_hsa00830	1.61678414
24	ABC transporters_Homo sapiens_hsa02010	1.57252564
25	Histidine metabolism_Homo sapiens_hsa00340	1.55975734
26	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55858536
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.54676392
28	Sphingolipid metabolism_Homo sapiens_hsa00600	1.54351982
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49398897
30	Chemical carcinogenesis_Homo sapiens_hsa05204	1.48188046
31	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.47145921
32	Peroxisome_Homo sapiens_hsa04146	1.40823058
33	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.39247098
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.37524102
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.36378380
36	PPAR signaling pathway_Homo sapiens_hsa03320	1.34807943
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.33674524
38	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.32773096
39	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29254294
40	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24095372
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.24049278
42	Phenylalanine metabolism_Homo sapiens_hsa00360	1.22933883
43	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.22208656
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.21002672
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.15634317
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.12751919
47	Tyrosine metabolism_Homo sapiens_hsa00350	1.10518951
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.08880330
49	Selenocompound metabolism_Homo sapiens_hsa00450	1.08859234
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.08841254
51	Propanoate metabolism_Homo sapiens_hsa00640	1.06274464
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03039113
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01912371
54	Regulation of autophagy_Homo sapiens_hsa04140	1.01758125
55	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01107901
56	Fatty acid elongation_Homo sapiens_hsa00062	0.98736033
57	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.94952805
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94866277
59	Galactose metabolism_Homo sapiens_hsa00052	0.86716126
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.86193463
61	Mineral absorption_Homo sapiens_hsa04978	0.84052137
62	Basal transcription factors_Homo sapiens_hsa03022	0.82044930
63	Lysine degradation_Homo sapiens_hsa00310	0.77219633
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.76193560
65	Sulfur metabolism_Homo sapiens_hsa00920	0.75748977
66	Bile secretion_Homo sapiens_hsa04976	0.74093669
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.73045733
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.72786238
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72648540
70	Nicotine addiction_Homo sapiens_hsa05033	0.64207640
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.62548636
72	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57031863
73	Metabolic pathways_Homo sapiens_hsa01100	0.52823383
74	Pertussis_Homo sapiens_hsa05133	0.51076020
75	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49264809
76	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.46907817
77	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.43490871
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42657470
79	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42194425
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.42065387
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.41147079
82	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.40435067
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.40269300
84	Phototransduction_Homo sapiens_hsa04744	0.39380652
85	Insulin resistance_Homo sapiens_hsa04931	0.37092549
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35691512
87	Glucagon signaling pathway_Homo sapiens_hsa04922	0.32215164
88	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.28446048
89	mTOR signaling pathway_Homo sapiens_hsa04150	0.25212266
90	One carbon pool by folate_Homo sapiens_hsa00670	0.25091339
91	Osteoclast differentiation_Homo sapiens_hsa04380	0.22997857
92	Taste transduction_Homo sapiens_hsa04742	0.22993863
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.22763167
94	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.22242620
95	Tuberculosis_Homo sapiens_hsa05152	0.22049309
96	Phagosome_Homo sapiens_hsa04145	0.19515100
97	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.18080080
98	RNA degradation_Homo sapiens_hsa03018	0.17152773
99	AMPK signaling pathway_Homo sapiens_hsa04152	0.16511950
100	Pyruvate metabolism_Homo sapiens_hsa00620	0.16110168

C16ORF70

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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