ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axoneme assembly (GO:0035082)	8.88159979
2	left/right pattern formation (GO:0060972)	7.92256101
3	regulation of cilium movement (GO:0003352)	6.89588873
4	primary alcohol catabolic process (GO:0034310)	6.30001411
5	ventricular system development (GO:0021591)	5.83932570
6	left/right axis specification (GO:0070986)	5.57168830
7	microtubule bundle formation (GO:0001578)	5.53762356
8	vitamin transmembrane transport (GO:0035461)	5.46671676
9	cellular response to ATP (GO:0071318)	5.34609172
10	centriole assembly (GO:0098534)	5.17166051
11	sperm capacitation (GO:0048240)	5.14070224
12	intraciliary transport (GO:0042073)	5.10256519
13	ethanol metabolic process (GO:0006067)	5.08156592
14	cilium organization (GO:0044782)	4.99685391
15	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.92971095
16	cilium assembly (GO:0042384)	4.85060268
17	GDP-mannose metabolic process (GO:0019673)	4.76057778
18	diterpenoid biosynthetic process (GO:0016102)	4.72546995
19	response to xenobiotic stimulus (GO:0009410)	4.58941527
20	lung epithelium development (GO:0060428)	4.56117612
21	tolerance induction (GO:0002507)	4.50792808
22	protein localization to cilium (GO:0061512)	4.47327795
23	establishment of apical/basal cell polarity (GO:0035089)	4.43005071
24	regulation of microtubule-based movement (GO:0060632)	4.32392446
25	regulation of skeletal muscle contraction (GO:0014819)	4.26232925
26	nucleotide transmembrane transport (GO:1901679)	4.24898398
27	negative regulation of T cell differentiation in thymus (GO:0033085)	4.17063219
28	cilium morphogenesis (GO:0060271)	4.15935559
29	negative regulation of cell aging (GO:0090344)	4.14250790
30	microtubule depolymerization (GO:0007019)	4.07527892
31	one-carbon compound transport (GO:0019755)	4.01364667
32	sensory perception of taste (GO:0050909)	3.96640286
33	sperm motility (GO:0030317)	3.93085729
34	microtubule-based movement (GO:0007018)	3.89029608
35	adenosine receptor signaling pathway (GO:0001973)	3.87054246
36	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.83538269
37	establishment of monopolar cell polarity (GO:0061162)	3.83538269
38	meiotic chromosome segregation (GO:0045132)	3.79662566
39	peptidyl-glutamic acid carboxylation (GO:0017187)	3.77419683
40	protein carboxylation (GO:0018214)	3.77419683
41	microtubule polymerization or depolymerization (GO:0031109)	3.74689205
42	cellular component assembly involved in morphogenesis (GO:0010927)	3.72572322
43	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	3.67027055
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.65973566
45	ethanol oxidation (GO:0006069)	3.62797518
46	regulation of interleukin-5 production (GO:0032674)	3.60436909
47	glomerular epithelial cell development (GO:0072310)	3.57829936
48	sialylation (GO:0097503)	3.56245663
49	negative regulation of B cell mediated immunity (GO:0002713)	3.52616312
50	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.52616312
51	regulation of germinal center formation (GO:0002634)	3.52401348
52	rRNA methylation (GO:0031167)	3.46434576
53	cell projection assembly (GO:0030031)	3.45733954
54	phosphatidylcholine biosynthetic process (GO:0006656)	3.43434830
55	glutathione derivative metabolic process (GO:1901685)	3.43073083
56	glutathione derivative biosynthetic process (GO:1901687)	3.43073083
57	regulation of interleukin-13 production (GO:0032656)	3.38169811
58	DNA strand renaturation (GO:0000733)	3.37272694
59	negative regulation of inclusion body assembly (GO:0090084)	3.33064643
60	terpenoid biosynthetic process (GO:0016114)	3.31796207
61	retinoic acid metabolic process (GO:0042573)	3.31615442
62	regulation of synapse structural plasticity (GO:0051823)	3.31421043
63	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	3.29161145
64	phosphatidylethanolamine metabolic process (GO:0046337)	3.27908234
65	O-glycan processing (GO:0016266)	3.19339364
66	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.17927507
67	sphingomyelin metabolic process (GO:0006684)	3.12458753
68	nucleoside diphosphate phosphorylation (GO:0006165)	3.10469283
69	retinol metabolic process (GO:0042572)	3.09897678
70	purinergic nucleotide receptor signaling pathway (GO:0035590)	3.08719028
71	lens fiber cell differentiation (GO:0070306)	3.03425941
72	negative regulation of humoral immune response (GO:0002921)	2.99617822
73	UV protection (GO:0009650)	2.99179445
74	cytoplasmic microtubule organization (GO:0031122)	2.97951402
75	establishment of tissue polarity (GO:0007164)	2.96530689
76	establishment of planar polarity (GO:0001736)	2.96530689
77	rRNA modification (GO:0000154)	2.94137550
78	cornea development in camera-type eye (GO:0061303)	2.92440651
79	glutathione biosynthetic process (GO:0006750)	2.92008508
80	positive regulation of protein kinase C signaling (GO:0090037)	2.91039461
81	exogenous drug catabolic process (GO:0042738)	2.88194266
82	primary alcohol metabolic process (GO:0034308)	2.86293552
83	renal absorption (GO:0070293)	2.85113345
84	spermatid development (GO:0007286)	2.84207169
85	glutathione metabolic process (GO:0006749)	2.76809415
86	positive regulation of tolerance induction (GO:0002645)	2.76034866
87	embryonic body morphogenesis (GO:0010172)	2.74070084
88	mitotic cell cycle arrest (GO:0071850)	2.73566123
89	detection of light stimulus involved in sensory perception (GO:0050962)	2.72581733
90	detection of light stimulus involved in visual perception (GO:0050908)	2.72581733
91	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.68917970
92	lateral ventricle development (GO:0021670)	2.68497167
93	nonribosomal peptide biosynthetic process (GO:0019184)	2.66067712
94	protein insertion into membrane (GO:0051205)	2.61889684
95	axonemal dynein complex assembly (GO:0070286)	18.2036114
96	cilium or flagellum-dependent cell motility (GO:0001539)	16.3646430
97	cilium movement (GO:0003341)	12.9955390
98	motile cilium assembly (GO:0044458)	12.9333247
99	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	11.6144832
100	epithelial cilium movement (GO:0003351)	11.4919039

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.28932612
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.69385610
3	* P68_20966046_ChIP-Seq_HELA_Human	3.21569195
4	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.04240502
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.81359270
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.72363536
7	SMC4_20622854_ChIP-Seq_HELA_Human	2.65256876
8	CTCF_27219007_Chip-Seq_Bcells_Human	2.63304912
9	E2F1_20622854_ChIP-Seq_HELA_Human	2.52258962
10	PHF8_20622854_ChIP-Seq_HELA_Human	2.50174068
11	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.42950127
12	BCL6_27268052_Chip-Seq_Bcells_Human	2.37494550
13	BCOR_27268052_Chip-Seq_Bcells_Human	2.35162283
14	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	2.28677808
15	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.25936515
16	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.24909414
17	RACK7_27058665_Chip-Seq_MCF-7_Human	2.19207177
18	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.15873787
19	DROSHA_22980978_ChIP-Seq_HELA_Human	2.13749098
20	YY1_22570637_ChIP-Seq_MALME-3M_Human	2.06449195
21	CTCF_20526341_ChIP-Seq_ESCs_Human	2.04189801
22	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	2.01240356
23	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.98001367
24	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.92829726
25	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.90658863
26	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.89785065
27	MAF_26560356_Chip-Seq_TH2_Human	1.86719556
28	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.84609981
29	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.83829134
30	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.83609588
31	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.81221541
32	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.77287001
33	TP63_22573176_ChIP-Seq_HFKS_Human	1.76707790
34	CREB1_26743006_Chip-Seq_LNCaP_Human	1.75341024
35	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.71776563
36	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71530808
37	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.67792606
38	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.62663255
39	ERA_21632823_ChIP-Seq_H3396_Human	1.61997792
40	P300_27268052_Chip-Seq_Bcells_Human	1.59482101
41	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.58295354
42	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.57573637
43	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.56610193
44	MAF_26560356_Chip-Seq_TH1_Human	1.56335497
45	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.54795634
46	XRN2_22483619_ChIP-Seq_HELA_Human	1.54423158
47	SA1_27219007_Chip-Seq_Bcells_Human	1.51605835
48	CTCF_21964334_Chip-Seq_Bcells_Human	1.50731948
49	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.50189160
50	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.50038010
51	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.48719961
52	VDR_24763502_ChIP-Seq_THP-1_Human	1.48252285
53	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.47834322
54	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.46613038
55	TP53_22127205_ChIP-Seq_IMR90_Human	1.44453438
56	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.44237728
57	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.42389371
58	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.40083630
59	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.39585459
60	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.37939705
61	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.34507080
62	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.30775033
63	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.30252256
64	OCT4_20526341_ChIP-Seq_ESCs_Human	1.28167296
65	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.26413815
66	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.24751059
67	P53_21459846_ChIP-Seq_SAOS-2_Human	1.23956920
68	SOX2_21211035_ChIP-Seq_LN229_Human	1.23218597
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.20811029
70	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.20099392
71	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.19912988
72	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.19747318
73	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.19152187
74	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.18917373
75	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.18841136
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17563171
77	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.17014037
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.16707161
79	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.15963072
80	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.15931732
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.15757457
82	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15634553
83	OCT4_19829295_ChIP-Seq_ESCs_Human	1.15148414
84	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.12104827
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.11452027
86	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.10977135
87	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10959400
88	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.10676114
89	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10305122
90	TAF2_19829295_ChIP-Seq_ESCs_Human	1.08503581
91	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.08057682
92	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.07137813
93	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.06823189
94	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.06583494
95	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.06328388
96	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.06217082
97	UTX_26944678_Chip-Seq_JUKART_Human	1.00828478
98	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.00620122
99	KLF5_25053715_ChIP-Seq_YYC3_Human	1.00416930
100	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.99795330

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	6.34216935
2	MP0003136_yellow_coat_color	5.22826877
3	MP0005171_absent_coat_pigmentation	5.15687262
4	MP0001986_abnormal_taste_sensitivity	4.67938659
5	MP0005174_abnormal_tail_pigmentation	4.27643047
6	MP0005423_abnormal_somatic_nervous	4.21282738
7	MP0002653_abnormal_ependyma_morphology	3.85899815
8	MP0004043_abnormal_pH_regulation	3.46905584
9	MP0001188_hyperpigmentation	3.29125103
10	MP0005409_darkened_coat_color	3.23627434
11	MP0002132_abnormal_respiratory_system	3.12601678
12	MP0005083_abnormal_biliary_tract	2.87545771
13	MP0002160_abnormal_reproductive_system	2.51738232
14	MP0002638_abnormal_pupillary_reflex	2.50943834
15	MP0004133_heterotaxia	2.37967491
16	MP0008789_abnormal_olfactory_epithelium	2.28449728
17	MP0001984_abnormal_olfaction	2.10447760
18	MP0002277_abnormal_respiratory_mucosa	2.08395874
19	MP0005377_hearing/vestibular/ear_phenot	2.07150704
20	MP0003878_abnormal_ear_physiology	2.07150704
21	MP0001968_abnormal_touch/_nociception	2.02546528
22	MP0001502_abnormal_circadian_rhythm	1.95381792
23	MP0001765_abnormal_ion_homeostasis	1.86887799
24	MP0004019_abnormal_vitamin_homeostasis	1.81431224
25	MP0009780_abnormal_chondrocyte_physiolo	1.79335192
26	MP0001756_abnormal_urination	1.72125271
27	MP0002735_abnormal_chemical_nociception	1.67725016
28	MP0005623_abnormal_meninges_morphology	1.64475117
29	MP0000015_abnormal_ear_pigmentation	1.62217593
30	MP0000751_myopathy	1.57175537
31	MP0005499_abnormal_olfactory_system	1.47366726
32	MP0005394_taste/olfaction_phenotype	1.47366726
33	MP0004381_abnormal_hair_follicle	1.44444606
34	MP0002909_abnormal_adrenal_gland	1.43992341
35	MP0003453_abnormal_keratinocyte_physiol	1.43453817
36	MP0005410_abnormal_fertilization	1.34881779
37	MP0000678_abnormal_parathyroid_gland	1.31212372
38	MP0002736_abnormal_nociception_after	1.29583110
39	MP0005389_reproductive_system_phenotype	1.24094698
40	MP0000013_abnormal_adipose_tissue	1.18932374
41	MP0000383_abnormal_hair_follicle	1.14373902
42	MP0001346_abnormal_lacrimal_gland	1.14189064
43	MP0001664_abnormal_digestion	1.14079238
44	MP0005365_abnormal_bile_salt	1.11298904
45	MP0001929_abnormal_gametogenesis	1.10972802
46	MP0005551_abnormal_eye_electrophysiolog	1.08255446
47	MP0003698_abnormal_male_reproductive	1.05445485
48	MP0002282_abnormal_trachea_morphology	1.03587575
49	MP0002249_abnormal_larynx_morphology	0.97626319
50	MP0003656_abnormal_erythrocyte_physiolo	0.96797036
51	MP0000566_synostosis	0.94470492
52	MP0009643_abnormal_urine_homeostasis	0.90315902
53	MP0001661_extended_life_span	0.89247468
54	MP0000538_abnormal_urinary_bladder	0.89053349
55	MP0002168_other_aberrant_phenotype	0.87297946
56	MP0005636_abnormal_mineral_homeostasis	0.85688162
57	MP0010030_abnormal_orbit_morphology	0.84220907
58	MP0001324_abnormal_eye_pigmentation	0.83107264
59	MP0010386_abnormal_urinary_bladder	0.81332379
60	MP0010678_abnormal_skin_adnexa	0.76784999
61	MP0002136_abnormal_kidney_physiology	0.74476705
62	MP0001970_abnormal_pain_threshold	0.73203859
63	MP0005395_other_phenotype	0.71546503
64	MP0005332_abnormal_amino_acid	0.70634359
65	MP0002928_abnormal_bile_duct	0.70363958
66	MP0000026_abnormal_inner_ear	0.68966290
67	MP0005501_abnormal_skin_physiology	0.66206012
68	MP0002210_abnormal_sex_determination	0.66119957
69	MP0001919_abnormal_reproductive_system	0.65815975
70	MP0005076_abnormal_cell_differentiation	0.64298164
71	MP0005220_abnormal_exocrine_pancreas	0.63762942
72	MP0003806_abnormal_nucleotide_metabolis	0.63728226
73	MP0000358_abnormal_cell_content/	0.62321495
74	MP0005330_cardiomyopathy	0.60410943
75	MP0005253_abnormal_eye_physiology	0.60337131
76	MP0002734_abnormal_mechanical_nocicepti	0.58933934
77	MP0002161_abnormal_fertility/fecundity	0.57405740
78	MP0005584_abnormal_enzyme/coenzyme_acti	0.56216197
79	MP0000003_abnormal_adipose_tissue	0.55900381
80	MP0010771_integument_phenotype	0.54188124
81	MP0005248_abnormal_Harderian_gland	0.52966201
82	MP0001905_abnormal_dopamine_level	0.52238548
83	MP0004130_abnormal_muscle_cell	0.51136858
84	MP0006036_abnormal_mitochondrial_physio	0.50111865
85	MP0001145_abnormal_male_reproductive	0.49032575
86	MP0005084_abnormal_gallbladder_morpholo	0.48480041
87	MP0003718_maternal_effect	0.47974000
88	MP0001270_distended_abdomen	0.46642749
89	MP0000750_abnormal_muscle_regeneration	0.46473605
90	MP0003303_peritoneal_inflammation	0.45921109
91	MP0002876_abnormal_thyroid_physiology	0.44656403
92	MP0003137_abnormal_impulse_conducting	0.43918743
93	MP0000653_abnormal_sex_gland	0.43200116
94	MP0000681_abnormal_thyroid_gland	0.41654771
95	MP0000367_abnormal_coat/_hair	0.40535211
96	MP0010155_abnormal_intestine_physiology	0.40494176
97	MP0005085_abnormal_gallbladder_physiolo	0.39230963
98	MP0000470_abnormal_stomach_morphology	0.38782557
99	MP0001944_abnormal_pancreas_morphology	0.38203112
100	MP0000747_muscle_weakness	0.38026615

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal respiratory epithelium morphology (HP:0012253)	9.84684876
2	Abnormal respiratory motile cilium morphology (HP:0005938)	9.84684876
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	9.56329107
4	Absent/shortened dynein arms (HP:0200106)	9.56329107
5	Abnormal respiratory motile cilium physiology (HP:0012261)	9.48865070
6	Abnormal ciliary motility (HP:0012262)	9.27806077
7	Rhinitis (HP:0012384)	8.59917299
8	Chronic bronchitis (HP:0004469)	6.56678241
9	Nasal polyposis (HP:0100582)	6.26092505
10	Bronchiectasis (HP:0002110)	6.25998654
11	Abnormality of the nasal mucosa (HP:0000433)	5.16426881
12	Male infertility (HP:0003251)	4.78319772
13	Infertility (HP:0000789)	4.54486089
14	Recurrent sinusitis (HP:0011108)	3.53737732
15	Bronchitis (HP:0012387)	3.47648850
16	Occipital encephalocele (HP:0002085)	3.31033081
17	Chronic sinusitis (HP:0011109)	3.27088087
18	Rib fusion (HP:0000902)	3.22188499
19	Recurrent otitis media (HP:0000403)	3.20770157
20	Testicular atrophy (HP:0000029)	3.14566616
21	Popliteal pterygium (HP:0009756)	3.12161343
22	Atelectasis (HP:0100750)	2.98975685
23	Pancreatic fibrosis (HP:0100732)	2.89614629
24	True hermaphroditism (HP:0010459)	2.87599973
25	Aplasia of the musculature (HP:0100854)	2.85715961
26	Fetal akinesia sequence (HP:0001989)	2.81394911
27	Nephronophthisis (HP:0000090)	2.79645183
28	Dyschromatopsia (HP:0007641)	2.77266879
29	Chronic hepatic failure (HP:0100626)	2.71048553
30	Molar tooth sign on MRI (HP:0002419)	2.65764164
31	Abnormality of midbrain morphology (HP:0002418)	2.65764164
32	Decreased circulating renin level (HP:0003351)	2.54586658
33	Attenuation of retinal blood vessels (HP:0007843)	2.49020515
34	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.46594647
35	Cystic liver disease (HP:0006706)	2.46512820
36	Hyperactive renin-angiotensin system (HP:0000841)	2.44616266
37	Poikiloderma (HP:0001029)	2.33900881
38	Pancreatic cysts (HP:0001737)	2.29438978
39	Chronic otitis media (HP:0000389)	2.28558739
40	Vaginal fistula (HP:0004320)	2.27317166
41	Ulnar bowing (HP:0003031)	2.23764725
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.20990985
43	Decreased central vision (HP:0007663)	2.18858214
44	Facial hemangioma (HP:0000329)	2.18348413
45	Congenital hepatic fibrosis (HP:0002612)	2.18194998
46	Annular pancreas (HP:0001734)	2.13407910
47	Abnormality of the renal medulla (HP:0100957)	2.10051918
48	Rectal fistula (HP:0100590)	2.09999345
49	Rectovaginal fistula (HP:0000143)	2.09999345
50	Tubular atrophy (HP:0000092)	2.06276401
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.7385312
52	Postaxial foot polydactyly (HP:0001830)	1.96197685
53	Turricephaly (HP:0000262)	1.95650627
54	Thin bony cortex (HP:0002753)	1.93848279
55	Congenital stationary night blindness (HP:0007642)	1.93292515
56	Akinesia (HP:0002304)	1.93129042
57	Intestinal fistula (HP:0100819)	1.92947095
58	Male pseudohermaphroditism (HP:0000037)	1.91846472
59	Anteriorly placed anus (HP:0001545)	1.90948332
60	Abnormal drinking behavior (HP:0030082)	1.89522397
61	Polydipsia (HP:0001959)	1.89522397
62	Anencephaly (HP:0002323)	1.80092768
63	Tubulointerstitial nephritis (HP:0001970)	1.79002867
64	Hemorrhage of the eye (HP:0011885)	1.73746186
65	Facial diplegia (HP:0001349)	1.70201200
66	Hyperkalemia (HP:0002153)	1.69997971
67	Coronal craniosynostosis (HP:0004440)	1.68733383
68	Abnormality of renin-angiotensin system (HP:0000847)	1.68480546
69	Hyponatremia (HP:0002902)	1.66326784
70	Bell-shaped thorax (HP:0001591)	1.64117600
71	Squamous cell carcinoma (HP:0002860)	1.63290910
72	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.61028796
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.59165402
74	Abnormality of the intrinsic pathway (HP:0010989)	1.55646189
75	Hypoalbuminemia (HP:0003073)	1.53090524
76	Abnormal albumin level (HP:0012116)	1.53090524
77	Nephropathy (HP:0000112)	1.51219754
78	Renal salt wasting (HP:0000127)	1.51151237
79	Choroideremia (HP:0001139)	1.49601335
80	Absent speech (HP:0001344)	1.49003256
81	Chorioretinal atrophy (HP:0000533)	1.47658885
82	Abnormality of the hepatic vasculature (HP:0006707)	1.47258191
83	Asplenia (HP:0001746)	1.45899490
84	Medial flaring of the eyebrow (HP:0010747)	1.44060889
85	Short thorax (HP:0010306)	1.43963207
86	Abnormality of the costochondral junction (HP:0000919)	1.43741056
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.43510607
88	Stage 5 chronic kidney disease (HP:0003774)	1.43006592
89	Mesangial abnormality (HP:0001966)	1.41485093
90	Prolonged partial thromboplastin time (HP:0003645)	1.38332011
91	Abnormality of chloride homeostasis (HP:0011422)	1.37884092
92	Joint hemorrhage (HP:0005261)	1.37832645
93	Abnormality of placental membranes (HP:0011409)	1.37806306
94	Amniotic constriction ring (HP:0009775)	1.37806306
95	Hand muscle atrophy (HP:0009130)	1.36124156
96	Recurrent bronchitis (HP:0002837)	1.35191143
97	Atrioventricular block (HP:0001678)	1.34563837
98	Hypophosphatemic rickets (HP:0004912)	1.34561835
99	Lip pit (HP:0100267)	1.34493449
100	Oculomotor apraxia (HP:0000657)	1.33598596

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	3.44635368
2	MST4	3.32211903
3	WNK4	2.85457067
4	TLK1	2.28056441
5	MAPK15	13.4468369
6	GRK6	1.75143993
7	MUSK	1.74038259
8	PNCK	1.44347431
9	BLK	1.39839409
10	MAPKAPK3	1.37621279
11	STK16	1.31141735
12	MST1R	1.25420745
13	EEF2K	1.24371119
14	TRIB3	1.24085913
15	CSK	1.15022167
16	SMG1	1.09182531
17	TTK	0.99039273
18	MAP3K3	0.98105214
19	NME1	0.98082530
20	MAP3K2	0.98015792
21	NEK6	0.96917999
22	PTK2B	0.96304056
23	CDK8	0.95192012
24	ADRBK1	0.92111884
25	PDPK1	0.91564544
26	TESK2	0.88249555
27	DYRK1B	0.87435546
28	ICK	0.83547655
29	PRKCI	0.81230133
30	SIK2	0.80514717
31	ACVR1B	0.80393865
32	TBK1	0.76724987
33	ADRBK2	0.74485789
34	CCNB1	0.72594030
35	STK24	0.69539771
36	PIM2	0.69535478
37	AURKA	0.69377539
38	STK38	0.66584189
39	WNK1	0.65800426
40	ZAP70	0.65121058
41	MET	0.62755036
42	LRRK2	0.60066062
43	PRKD2	0.58326368
44	RIPK4	0.57723226
45	ARAF	0.57666475
46	ZAK	0.57583701
47	PLK4	0.56258033
48	MAP3K7	0.55893231
49	MARK2	0.55598432
50	MAP2K2	0.55570230
51	RPS6KA2	0.54060433
52	NEK2	0.54050976
53	STK39	0.51222572
54	TESK1	0.50595525
55	CDK6	0.48590126
56	OXSR1	0.48012137
57	CAMKK1	0.46362436
58	PLK1	0.45506897
59	EPHB1	0.44386554
60	PRKD1	0.42708141
61	TRPM7	0.41714868
62	BMPR1B	0.39528581
63	PRKCQ	0.37540688
64	MAP2K1	0.35632167
65	PRKD3	0.35623296
66	SGK494	0.34880734
67	SGK223	0.34880734
68	RPS6KB2	0.34529427
69	DYRK3	0.33752828
70	PBK	0.33135066
71	PRKCD	0.30891159
72	MAPK11	0.30882093
73	SGK1	0.30445508
74	AKT2	0.30008410
75	CDK4	0.29934816
76	ERBB2	0.29525065
77	IRAK2	0.29468887
78	ERN1	0.28934117
79	PAK1	0.28074864
80	MAPK12	0.26654291
81	CHEK2	0.26073820
82	MAP2K3	0.25572348
83	CAMK2G	0.25363040
84	PINK1	0.25173517
85	MAP2K6	0.25125631
86	STK10	0.23880864
87	ATR	0.22590281
88	TSSK6	0.22027690
89	BMX	0.21726522
90	PRKACA	0.21135423
91	PAK4	0.20709734
92	NEK9	0.20653506
93	MAP2K4	0.20497217
94	ROCK1	0.20479399
95	GRK1	0.20260344
96	CDK12	0.19902619
97	STK11	0.19782996
98	MAPK8	0.18578333
99	HIPK2	0.17427924
100	RPS6KA6	0.17266591

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.66897292
2	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.99490838
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.96015655
4	Phenylalanine metabolism_Homo sapiens_hsa00360	3.91289128
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.71952973
6	Sulfur relay system_Homo sapiens_hsa04122	3.50425899
7	Chemical carcinogenesis_Homo sapiens_hsa05204	3.40757502
8	Histidine metabolism_Homo sapiens_hsa00340	3.14199481
9	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.03408782
10	Tyrosine metabolism_Homo sapiens_hsa00350	2.81664985
11	Sphingolipid metabolism_Homo sapiens_hsa00600	2.29051313
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.06860311
13	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.98227473
14	Glutathione metabolism_Homo sapiens_hsa00480	1.96560968
15	beta-Alanine metabolism_Homo sapiens_hsa00410	1.94826037
16	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.92680893
17	Huntingtons disease_Homo sapiens_hsa05016	1.91873310
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.88754911
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.87556012
20	Circadian rhythm_Homo sapiens_hsa04710	1.71341392
21	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.64072681
22	Retinol metabolism_Homo sapiens_hsa00830	1.53918509
23	Taste transduction_Homo sapiens_hsa04742	1.52972979
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48763309
25	Caffeine metabolism_Homo sapiens_hsa00232	1.48248728
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.46991546
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.36265199
28	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.32681927
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22679947
30	Fatty acid degradation_Homo sapiens_hsa00071	1.18915090
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14548856
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10347473
33	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.04785930
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.03075605
35	ABC transporters_Homo sapiens_hsa02010	1.02521405
36	Nicotine addiction_Homo sapiens_hsa05033	1.02130680
37	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.95001323
38	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83954474
39	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83372777
40	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.81086752
41	Cocaine addiction_Homo sapiens_hsa05030	0.71210884
42	Peroxisome_Homo sapiens_hsa04146	0.69807438
43	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.69105309
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.64914257
45	Pyruvate metabolism_Homo sapiens_hsa00620	0.61951138
46	Tight junction_Homo sapiens_hsa04530	0.61227910
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57904625
48	Basal cell carcinoma_Homo sapiens_hsa05217	0.57777551
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.55378345
50	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53992309
51	Metabolic pathways_Homo sapiens_hsa01100	0.52586423
52	Lysosome_Homo sapiens_hsa04142	0.50830043
53	Notch signaling pathway_Homo sapiens_hsa04330	0.49755359
54	Hippo signaling pathway_Homo sapiens_hsa04390	0.48236437
55	Phototransduction_Homo sapiens_hsa04744	0.46461067
56	PPAR signaling pathway_Homo sapiens_hsa03320	0.46305422
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.44768946
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.42172486
59	Nitrogen metabolism_Homo sapiens_hsa00910	0.41100007
60	Salivary secretion_Homo sapiens_hsa04970	0.39715323
61	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37959117
62	Melanogenesis_Homo sapiens_hsa04916	0.36514995
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36415256
64	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.33003903
65	Arginine biosynthesis_Homo sapiens_hsa00220	0.30158357
66	Endocytosis_Homo sapiens_hsa04144	0.27795047
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.27540222
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.27449340
69	Hepatitis C_Homo sapiens_hsa05160	0.27082863
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.26868254
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.26304828
72	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.21239975
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20564233
74	Amphetamine addiction_Homo sapiens_hsa05031	0.20040365
75	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.19821111
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.19438383
77	Insulin resistance_Homo sapiens_hsa04931	0.18367891
78	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.18361497
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.18196462
80	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.17760083
81	Olfactory transduction_Homo sapiens_hsa04740	0.17295683
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.17224691
83	Gap junction_Homo sapiens_hsa04540	0.16037453
84	Basal transcription factors_Homo sapiens_hsa03022	0.15014396
85	Axon guidance_Homo sapiens_hsa04360	0.12827568
86	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.10400284
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.09882274
88	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.09764725
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.08891251
90	Bile secretion_Homo sapiens_hsa04976	0.08821506
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.08474457
92	Choline metabolism in cancer_Homo sapiens_hsa05231	0.08108056
93	Purine metabolism_Homo sapiens_hsa00230	0.07769474
94	Mineral absorption_Homo sapiens_hsa04978	0.07257475
95	Alcoholism_Homo sapiens_hsa05034	0.07144946
96	Base excision repair_Homo sapiens_hsa03410	0.05446915
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.04789240
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.04225336
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.03910401
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.03054330

C16ORF71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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