ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	8.99696703
2	DNA packaging (GO:0006323)	8.73371184
3	sperm capacitation (GO:0048240)	8.62222196
4	spermatid nucleus differentiation (GO:0007289)	8.41097353
5	single strand break repair (GO:0000012)	8.23549726
6	microtubule depolymerization (GO:0007019)	8.18961666
7	protein targeting to Golgi (GO:0000042)	8.04997109
8	plasma membrane fusion (GO:0045026)	7.89102746
9	response to pheromone (GO:0019236)	7.87332135
10	spermatid development (GO:0007286)	7.72889936
11	establishment of protein localization to Golgi (GO:0072600)	7.71042606
12	retrograde transport, vesicle recycling within Golgi (GO:0000301)	7.49111377
13	protein polyglutamylation (GO:0018095)	7.35112115
14	sperm-egg recognition (GO:0035036)	7.13667063
15	rRNA methylation (GO:0031167)	7.01080669
16	microtubule polymerization or depolymerization (GO:0031109)	6.98592926
17	multicellular organism reproduction (GO:0032504)	6.63651390
18	binding of sperm to zona pellucida (GO:0007339)	6.57431351
19	sexual reproduction (GO:0019953)	6.50813492
20	axonemal dynein complex assembly (GO:0070286)	6.39250819
21	reproduction (GO:0000003)	6.37266280
22	calcium ion-dependent exocytosis (GO:0017156)	6.30093963
23	spermatogenesis (GO:0007283)	6.18583036
24	male gamete generation (GO:0048232)	6.16447928
25	protein localization to Golgi apparatus (GO:0034067)	6.15383700
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.15120493
27	centriole replication (GO:0007099)	6.03267431
28	microtubule severing (GO:0051013)	5.99037300
29	rRNA modification (GO:0000154)	5.93482924
30	negative regulation of inclusion body assembly (GO:0090084)	5.89390930
31	cell-cell recognition (GO:0009988)	5.83091017
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.70173810
33	gamete generation (GO:0007276)	5.65804722
34	centriole assembly (GO:0098534)	5.26664777
35	regulation of cilium movement (GO:0003352)	5.23058377
36	cilium or flagellum-dependent cell motility (GO:0001539)	5.17017476
37	motile cilium assembly (GO:0044458)	5.16767972
38	regulation of centriole replication (GO:0046599)	5.14696980
39	seminiferous tubule development (GO:0072520)	4.96837938
40	RNA destabilization (GO:0050779)	4.89441210
41	single fertilization (GO:0007338)	4.89306339
42	positive regulation of Rab GTPase activity (GO:0032851)	4.85286443
43	regulation of Rab GTPase activity (GO:0032313)	4.85286443
44	chromatin silencing (GO:0006342)	4.77718635
45	cellular ketone body metabolic process (GO:0046950)	4.66578525
46	epithelial cilium movement (GO:0003351)	4.52575014
47	musculoskeletal movement (GO:0050881)	4.51617438
48	multicellular organismal movement (GO:0050879)	4.51617438
49	multicellular organismal reproductive process (GO:0048609)	4.50823870
50	germ cell development (GO:0007281)	4.40947251
51	regulation of transcription involved in cell fate commitment (GO:0060850)	4.39489082
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.21662240
53	nucleus organization (GO:0006997)	4.21456505
54	fertilization (GO:0009566)	4.18101211
55	cell wall macromolecule catabolic process (GO:0016998)	4.16542548
56	regulation of inclusion body assembly (GO:0090083)	4.11814698
57	ketone body metabolic process (GO:1902224)	4.11302569
58	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.04730674
59	cell wall macromolecule metabolic process (GO:0044036)	4.03421551
60	cilium movement (GO:0003341)	3.92939192
61	glycerol ether metabolic process (GO:0006662)	3.92912019
62	glomerular visceral epithelial cell development (GO:0072015)	3.89551090
63	microtubule nucleation (GO:0007020)	3.87062241
64	coenzyme catabolic process (GO:0009109)	3.72697132
65	glomerular epithelial cell development (GO:0072310)	3.69250055
66	cerebral cortex neuron differentiation (GO:0021895)	3.64881876
67	ether metabolic process (GO:0018904)	3.62719391
68	nucleosome disassembly (GO:0006337)	3.51721564
69	protein-DNA complex disassembly (GO:0032986)	3.51721564
70	negative regulation of gene expression, epigenetic (GO:0045814)	3.37156383
71	polyamine biosynthetic process (GO:0006596)	3.37096595
72	regulation of microtubule-based movement (GO:0060632)	3.31199715
73	regulation of somitogenesis (GO:0014807)	3.17237486
74	organic cation transport (GO:0015695)	3.17185559
75	histone H3-K9 demethylation (GO:0033169)	3.16887293
76	negative regulation of Rho protein signal transduction (GO:0035024)	3.14595603
77	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.12565392
78	peptidyl-threonine dephosphorylation (GO:0035970)	3.07621822
79	membrane protein intracellular domain proteolysis (GO:0031293)	3.06873686
80	intra-Golgi vesicle-mediated transport (GO:0006891)	3.05891208
81	protein depolymerization (GO:0051261)	3.05480149
82	multicellular organismal development (GO:0007275)	3.01350034
83	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.00299515
84	regulation of interleukin-13 production (GO:0032656)	2.98817357
85	cell recognition (GO:0008037)	2.95905570
86	response to acidic pH (GO:0010447)	2.94051272
87	cellular response to pH (GO:0071467)	2.92753167
88	Golgi to endosome transport (GO:0006895)	2.80989685
89	homeostasis of number of cells within a tissue (GO:0048873)	2.80826317
90	receptor recycling (GO:0001881)	2.73596083
91	mitochondrial fission (GO:0000266)	2.70529562
92	axoneme assembly (GO:0035082)	2.69903582
93	DNA conformation change (GO:0071103)	2.69441781
94	regulation of T-helper 2 cell differentiation (GO:0045628)	2.68738525
95	spinal cord motor neuron differentiation (GO:0021522)	2.68658245
96	positive regulation of guanylate cyclase activity (GO:0031284)	2.64982940
97	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.64947156
98	sperm motility (GO:0030317)	11.7233698
99	acrosome reaction (GO:0007340)	11.5419552
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.2304427

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.21186875
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.17993122
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.19555564
4	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.57599019
5	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.57599019
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.49627243
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.46606366
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.34339877
9	FUS_26573619_Chip-Seq_HEK293_Human	2.22652620
10	* CBP_20019798_ChIP-Seq_JUKART_Human	2.22011397
11	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.22011397
12	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.10623883
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.07526413
14	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.93177827
15	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.85090952
16	ERA_21632823_ChIP-Seq_H3396_Human	1.81466460
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.80340702
18	RAC3_21632823_ChIP-Seq_H3396_Human	1.76773282
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.75571614
20	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70715003
21	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.69343627
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67711317
23	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.64458861
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63720358
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62502908
26	AR_25329375_ChIP-Seq_VCAP_Human	1.62303945
27	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.57681451
28	P300_19829295_ChIP-Seq_ESCs_Human	1.56018543
29	TAF15_26573619_Chip-Seq_HEK293_Human	1.55912173
30	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.55082678
31	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.54931077
32	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.53735654
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.53527987
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.53445586
35	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.53231174
36	MYC_19829295_ChIP-Seq_ESCs_Human	1.51889747
37	CTCF_27219007_Chip-Seq_Bcells_Human	1.49959983
38	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.49396580
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.48214672
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.48035261
41	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.46607877
42	OCT4_20526341_ChIP-Seq_ESCs_Human	1.39960849
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.37418576
44	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.36659566
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.32056495
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.31936170
47	CTCF_20526341_ChIP-Seq_ESCs_Human	1.31511159
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.31305786
49	RBPJ_21746931_ChIP-Seq_IB4_Human	1.31075270
50	TP53_18474530_ChIP-ChIP_U2OS_Human	1.30988232
51	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.30161062
52	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.30042984
53	ETV1_20927104_ChIP-Seq_GIST48_Human	1.29982404
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.28209901
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27353397
56	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.27278719
57	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.26815336
58	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.24273926
59	TBL1_22424771_ChIP-Seq_293T_Human	1.23614424
60	NFYB_21822215_ChIP-Seq_K562_Human	1.22874511
61	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21311777
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20336449
63	PHF8_20622854_ChIP-Seq_HELA_Human	1.19911106
64	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.19827800
65	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.19559275
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.19555225
67	E2F1_20622854_ChIP-Seq_HELA_Human	1.19467486
68	BCOR_27268052_Chip-Seq_Bcells_Human	1.19363553
69	TP63_22573176_ChIP-Seq_HFKS_Human	1.18623458
70	SMC4_20622854_ChIP-Seq_HELA_Human	1.18595944
71	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17827017
72	STAT3_23295773_ChIP-Seq_U87_Human	1.17778442
73	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.17065889
74	P68_20966046_ChIP-Seq_HELA_Human	1.16902009
75	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.16662297
76	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16611347
77	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.16144950
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15380500
79	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14977755
80	CEBPB_22108803_ChIP-Seq_LS180_Human	1.12005236
81	PHF8_20622853_ChIP-Seq_HELA_Human	1.11343931
82	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.09331423
83	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.09094227
84	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.09091646
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09048635
86	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.09004053
87	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08963271
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08963271
89	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.08352568
90	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07482582
91	KDM2B_26808549_Chip-Seq_REH_Human	1.06870765
92	SMRT_27268052_Chip-Seq_Bcells_Human	1.06462906
93	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.05782454
94	P300_27268052_Chip-Seq_Bcells_Human	1.03625076
95	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.03524475
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02985552
97	AR_21572438_ChIP-Seq_LNCaP_Human	1.02149234
98	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02126386
99	NFYA_21822215_ChIP-Seq_K562_Human	1.02020586
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.00745910

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.12465575
2	MP0005377_hearing/vestibular/ear_phenot	5.12465575
3	MP0003698_abnormal_male_reproductive	4.25940160
4	MP0005670_abnormal_white_adipose	3.96215582
5	MP0001929_abnormal_gametogenesis	3.71321137
6	MP0001348_abnormal_lacrimal_gland	3.52870522
7	MP0003646_muscle_fatigue	2.42144243
8	MP0002161_abnormal_fertility/fecundity	2.37125556
9	MP0005379_endocrine/exocrine_gland_phen	2.21491070
10	MP0000678_abnormal_parathyroid_gland	2.06753738
11	MP0003011_delayed_dark_adaptation	2.01666630
12	MP0003718_maternal_effect	2.01369303
13	MP0005410_abnormal_fertilization	11.5696903
14	MP0002653_abnormal_ependyma_morphology	1.73178036
15	MP0002210_abnormal_sex_determination	1.72726142
16	MP0005423_abnormal_somatic_nervous	1.69034408
17	MP0002132_abnormal_respiratory_system	1.67665646
18	MP0001486_abnormal_startle_reflex	1.62235513
19	MP0001485_abnormal_pinna_reflex	1.59810575
20	MP0002234_abnormal_pharynx_morphology	1.47407653
21	MP0004859_abnormal_synaptic_plasticity	1.41150638
22	MP0001145_abnormal_male_reproductive	1.37859575
23	MP0002249_abnormal_larynx_morphology	1.36975994
24	MP0002282_abnormal_trachea_morphology	1.29872261
25	MP0003879_abnormal_hair_cell	1.29613167
26	MP0000653_abnormal_sex_gland	1.29461559
27	MP0000534_abnormal_ureter_morphology	1.23776987
28	MP0000026_abnormal_inner_ear	1.22089684
29	MP0004742_abnormal_vestibular_system	1.21818990
30	MP0005253_abnormal_eye_physiology	1.19484913
31	MP0002735_abnormal_chemical_nociception	1.17468687
32	MP0001963_abnormal_hearing_physiology	1.17371433
33	MP0002822_catalepsy	1.16400229
34	MP0005310_abnormal_salivary_gland	1.14246215
35	MP0009053_abnormal_anal_canal	1.10525841
36	MP0002127_abnormal_cardiovascular_syste	1.09638474
37	MP0000955_abnormal_spinal_cord	1.07048899
38	MP0008789_abnormal_olfactory_epithelium	0.99761593
39	MP0005248_abnormal_Harderian_gland	0.99456891
40	MP0008877_abnormal_DNA_methylation	0.99195374
41	MP0005551_abnormal_eye_electrophysiolog	0.98784383
42	MP0001968_abnormal_touch/_nociception	0.98674456
43	MP0001765_abnormal_ion_homeostasis	0.96973021
44	MP0004510_myositis	0.96114604
45	MP0005171_absent_coat_pigmentation	0.94719128
46	MP0004085_abnormal_heartbeat	0.93558307
47	MP0008961_abnormal_basal_metabolism	0.93346999
48	MP0000049_abnormal_middle_ear	0.93240505
49	MP0005395_other_phenotype	0.92418245
50	MP0005451_abnormal_body_composition	0.92236995
51	MP0002928_abnormal_bile_duct	0.91732789
52	MP0000681_abnormal_thyroid_gland	0.89625901
53	MP0002067_abnormal_sensory_capabilities	0.89142401
54	MP0009697_abnormal_copulation	0.87365771
55	MP0009115_abnormal_fat_cell	0.85241180
56	MP0002229_neurodegeneration	0.84537237
57	MP0003137_abnormal_impulse_conducting	0.80859266
58	MP0004133_heterotaxia	0.80454998
59	MP0002733_abnormal_thermal_nociception	0.78235682
60	MP0005394_taste/olfaction_phenotype	0.77365839
61	MP0005499_abnormal_olfactory_system	0.77365839
62	MP0005083_abnormal_biliary_tract	0.77352053
63	MP0002138_abnormal_hepatobiliary_system	0.76828388
64	MP0008569_lethality_at_weaning	0.76392535
65	MP0002557_abnormal_social/conspecific_i	0.74049576
66	MP0005367_renal/urinary_system_phenotyp	0.70871741
67	MP0000516_abnormal_urinary_system	0.70871741
68	MP0003880_abnormal_central_pattern	0.67557602
69	MP0003122_maternal_imprinting	0.67501844
70	MP0009745_abnormal_behavioral_response	0.67323775
71	MP0001905_abnormal_dopamine_level	0.66139920
72	MP0001984_abnormal_olfaction	0.65531663
73	MP0005666_abnormal_adipose_tissue	0.64819685
74	MP0005391_vision/eye_phenotype	0.64433723
75	MP0000566_synostosis	0.62272645
76	MP0002572_abnormal_emotion/affect_behav	0.61368550
77	MP0005645_abnormal_hypothalamus_physiol	0.59431183
78	MP0005167_abnormal_blood-brain_barrier	0.59237081
79	MP0002272_abnormal_nervous_system	0.56542304
80	MP0006276_abnormal_autonomic_nervous	0.54705036
81	MP0008995_early_reproductive_senescence	0.53956469
82	MP0001529_abnormal_vocalization	0.53734232
83	MP0005084_abnormal_gallbladder_morpholo	0.53535648
84	MP0001970_abnormal_pain_threshold	0.53459594
85	MP0004233_abnormal_muscle_weight	0.53065893
86	MP0001440_abnormal_grooming_behavior	0.52077926
87	MP0003121_genomic_imprinting	0.52062787
88	MP0006292_abnormal_olfactory_placode	0.51682871
89	MP0001293_anophthalmia	0.49819619
90	MP0002932_abnormal_joint_morphology	0.49277380
91	MP0002882_abnormal_neuron_morphology	0.48267173
92	MP0001666_abnormal_nutrient_absorption	0.46965912
93	MP0006072_abnormal_retinal_apoptosis	0.46438128
94	MP0002734_abnormal_mechanical_nocicepti	0.46317385
95	MP0002095_abnormal_skin_pigmentation	0.45155333
96	MP0001879_abnormal_lymphatic_vessel	0.45054997
97	MP0002938_white_spotting	0.44855244
98	MP0005535_abnormal_body_temperature	0.44292851
99	MP0003635_abnormal_synaptic_transmissio	0.44249292
100	MP0003861_abnormal_nervous_system	0.42811821

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	6.94553649
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.42935340
3	Absent/shortened dynein arms (HP:0200106)	6.42935340
4	Chronic hepatic failure (HP:0100626)	5.88265543
5	Tubulointerstitial nephritis (HP:0001970)	5.59630967
6	Asymmetric septal hypertrophy (HP:0001670)	4.89836464
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.82883772
8	Abnormal respiratory epithelium morphology (HP:0012253)	4.78737835
9	Abnormal respiratory motile cilium morphology (HP:0005938)	4.78737835
10	Abnormal ciliary motility (HP:0012262)	4.77642182
11	Bony spicule pigmentary retinopathy (HP:0007737)	4.75578753
12	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.63601959
13	Attenuation of retinal blood vessels (HP:0007843)	4.59751615
14	Nasal polyposis (HP:0100582)	4.18213990
15	Male infertility (HP:0003251)	4.12581848
16	Infertility (HP:0000789)	4.08791234
17	Hyperkalemia (HP:0002153)	3.93085632
18	Cone-rod dystrophy (HP:0000548)	3.90046138
19	Potter facies (HP:0002009)	3.89223641
20	Facial shape deformation (HP:0011334)	3.89223641
21	Resting tremor (HP:0002322)	3.87241964
22	Abnormality of macular pigmentation (HP:0008002)	3.84632491
23	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.84495114
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.76591948
25	Bell-shaped thorax (HP:0001591)	3.35919497
26	Abnormality of the nasal mucosa (HP:0000433)	3.33945748
27	Nephronophthisis (HP:0000090)	3.30732097
28	Progressive sensorineural hearing impairment (HP:0000408)	3.29925247
29	Abnormal rod and cone electroretinograms (HP:0008323)	3.27805897
30	Progressive cerebellar ataxia (HP:0002073)	3.26326531
31	Amelogenesis imperfecta (HP:0000705)	3.24537142
32	Hypoalphalipoproteinemia (HP:0003233)	3.14914808
33	Hypoplasia of the thymus (HP:0000778)	3.08262456
34	Abnormality of the renal medulla (HP:0100957)	2.96516820
35	Abnormality of dental color (HP:0011073)	2.92685937
36	Rhinitis (HP:0012384)	2.91717156
37	Postural instability (HP:0002172)	2.89428544
38	Hypoplastic ischia (HP:0003175)	2.89059740
39	Impulsivity (HP:0100710)	2.87371710
40	Enlarged epiphyses (HP:0010580)	2.82732658
41	Stage 5 chronic kidney disease (HP:0003774)	2.76138966
42	Truncal obesity (HP:0001956)	2.75962404
43	Abnormal spermatogenesis (HP:0008669)	2.74001642
44	Generalized aminoaciduria (HP:0002909)	2.68486229
45	Portal hypertension (HP:0001409)	2.65053854
46	Osteomalacia (HP:0002749)	2.64136534
47	Abnormality of the ischium (HP:0003174)	2.61625932
48	Tubulointerstitial abnormality (HP:0001969)	2.60244770
49	Renal dysplasia (HP:0000110)	2.58804849
50	Menstrual irregularities (HP:0000858)	2.58097551
51	Chronic bronchitis (HP:0004469)	2.53015399
52	Abnormal urine output (HP:0012590)	2.52084902
53	Congenital sensorineural hearing impairment (HP:0008527)	2.47398422
54	Azoospermia (HP:0000027)	2.44942187
55	Unilateral renal agenesis (HP:0000122)	2.42577751
56	Renovascular hypertension (HP:0100817)	2.41209128
57	Abnormality of the hepatic vasculature (HP:0006707)	2.41088022
58	Abnormality of renal excretion (HP:0011036)	2.37241322
59	Abnormality of the costochondral junction (HP:0000919)	2.36746007
60	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.34831952
61	Polydipsia (HP:0001959)	2.34557533
62	Abnormal drinking behavior (HP:0030082)	2.34557533
63	Double outlet right ventricle (HP:0001719)	2.33089823
64	Congenital malformation of the right heart (HP:0011723)	2.33089823
65	Insulin-resistant diabetes mellitus (HP:0000831)	2.31893543
66	Abnormality of the aortic arch (HP:0012303)	2.30971700
67	Abnormality of potassium homeostasis (HP:0011042)	2.30061600
68	Intellectual disability, moderate (HP:0002342)	2.29852815
69	Abnormality of the parathyroid morphology (HP:0011766)	2.28631788
70	Myokymia (HP:0002411)	2.21324387
71	Failure to thrive in infancy (HP:0001531)	2.19762437
72	Occipital encephalocele (HP:0002085)	2.09833025
73	Bronchiectasis (HP:0002110)	2.08749503
74	Polyuria (HP:0000103)	2.04978655
75	Progressive hearing impairment (HP:0001730)	2.01778987
76	Pendular nystagmus (HP:0012043)	2.01611865
77	Increased purine levels (HP:0004368)	1.97415469
78	Hyperuricemia (HP:0002149)	1.97415469
79	Preauricular pit (HP:0004467)	1.96424307
80	Periauricular skin pits (HP:0100277)	1.96424307
81	Spastic paraparesis (HP:0002313)	1.94085578
82	Anterior segment dysgenesis (HP:0007700)	1.94071691
83	Focal segmental glomerulosclerosis (HP:0000097)	1.92351916
84	Atelectasis (HP:0100750)	1.86284348
85	Optic nerve hypoplasia (HP:0000609)	1.85550694
86	Peripheral hypomyelination (HP:0007182)	1.85457195
87	Chorioretinal atrophy (HP:0000533)	1.83052513
88	Abnormal albumin level (HP:0012116)	1.79156645
89	Hypoalbuminemia (HP:0003073)	1.79156645
90	Ventricular tachycardia (HP:0004756)	1.78993974
91	Pancreatic fibrosis (HP:0100732)	1.78789569
92	True hermaphroditism (HP:0010459)	1.77684574
93	Widely patent fontanelles and sutures (HP:0004492)	1.75757474
94	Abnormality of the pubic bones (HP:0003172)	1.72541311
95	Decreased central vision (HP:0007663)	1.71739934
96	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.70443736
97	Tubular atrophy (HP:0000092)	1.69182584
98	Genetic anticipation (HP:0003743)	1.63078347
99	Hyperthyroidism (HP:0000836)	1.61949950
100	Type II lissencephaly (HP:0007260)	1.61356435

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.82336523
2	TESK1	4.83017634
3	INSRR	3.98297131
4	MAP4K2	3.78371478
5	DDR2	3.51126674
6	BRD4	3.41788260
7	PLK2	3.36815721
8	PNCK	3.24450190
9	STK38	2.95216780
10	STK38L	2.74680852
11	CAMK1G	2.62297490
12	PRKD3	2.04553549
13	PIK3CG	1.91931879
14	MAPK15	1.88436343
15	PDK1	1.41443764
16	PDPK1	1.35794920
17	DYRK1B	1.35355454
18	NEK6	1.33382268
19	WNK1	1.31192169
20	MAP3K9	1.27896897
21	MST1R	1.27809430
22	SIK2	1.27191954
23	AKT3	1.14592297
24	CAMK1D	1.14348719
25	MARK1	1.12556808
26	PTK2B	1.04961026
27	TYRO3	1.02469364
28	WNK3	1.01033372
29	BMPR1B	1.00941371
30	CDK7	0.98707919
31	GRK7	0.92886787
32	MAP3K11	0.92574790
33	CDK12	0.84459232
34	KSR2	0.82946537
35	BRAF	0.80046887
36	MARK2	0.78588853
37	DYRK3	0.77981518
38	RPS6KA2	0.75300053
39	LATS2	0.73840144
40	PRKG2	0.68674390
41	UHMK1	0.68142434
42	FRK	0.64920800
43	BRSK1	0.63791261
44	SGK223	0.62917383
45	SGK494	0.62917383
46	PRKAA2	0.60490892
47	PRKG1	0.59638449
48	TIE1	0.59537033
49	MAP3K4	0.58632485
50	BRSK2	0.58279932
51	CAMK1	0.53930254
52	MAP2K2	0.51395372
53	CDK3	0.50404005
54	RPS6KA1	0.49771447
55	PINK1	0.47665214
56	PRKCG	0.46134076
57	MAP2K7	0.45383064
58	CAMKK2	0.44233302
59	CAMK4	0.44193251
60	ROCK1	0.42594525
61	GSK3B	0.40694687
62	CDK2	0.38797342
63	STK39	0.38322737
64	MAPK1	0.38215257
65	CDK1	0.36998903
66	RPS6KL1	0.36401073
67	RPS6KC1	0.36401073
68	WNK4	0.35770590
69	DYRK2	0.35414426
70	RPS6KA6	0.34143426
71	SGK2	0.33020347
72	LATS1	0.32796003
73	PRKCZ	0.31991932
74	MAP3K8	0.31590493
75	MUSK	0.30920732
76	MAPK8	0.30230537
77	ACVR1B	0.29230727
78	SGK1	0.26490269
79	MAP3K1	0.24340541
80	CHEK1	0.23205683
81	NTRK3	0.23189788
82	PRKCB	0.21810614
83	MKNK2	0.21758857
84	PRKACA	0.20565738
85	MAP3K2	0.20059079
86	MAPK14	0.19681447
87	PKN1	0.19551349
88	FER	0.19170573
89	DYRK1A	0.18664492
90	CDK19	0.18529162
91	AKT1	0.17851212
92	MAPK10	0.16152931
93	MTOR	0.14880805
94	ERBB3	0.14031517
95	PRKAA1	0.13769092
96	STK3	0.12932242
97	BLK	0.12806603
98	TNIK	0.12693346
99	MAPK11	0.12149511
100	PRKACB	0.11851956

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.11879048
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.34305006
3	Olfactory transduction_Homo sapiens_hsa04740	3.99714547
4	Butanoate metabolism_Homo sapiens_hsa00650	2.58457315
5	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.94586172
6	RNA transport_Homo sapiens_hsa03013	1.76853985
7	Taste transduction_Homo sapiens_hsa04742	1.71387473
8	Fatty acid degradation_Homo sapiens_hsa00071	1.67377162
9	Phenylalanine metabolism_Homo sapiens_hsa00360	1.66357024
10	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.58406312
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.57241104
12	Phototransduction_Homo sapiens_hsa04744	1.56641977
13	Type II diabetes mellitus_Homo sapiens_hsa04930	1.55791547
14	Fatty acid metabolism_Homo sapiens_hsa01212	1.53753090
15	Type I diabetes mellitus_Homo sapiens_hsa04940	1.48219809
16	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.48036629
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.43743715
18	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.40579967
19	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.38940935
20	Allograft rejection_Homo sapiens_hsa05330	1.38003202
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.37497137
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.28545658
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28198264
24	Morphine addiction_Homo sapiens_hsa05032	1.27024207
25	Graft-versus-host disease_Homo sapiens_hsa05332	1.26855165
26	Nicotine addiction_Homo sapiens_hsa05033	1.22973763
27	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.21099348
28	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20504104
29	Circadian entrainment_Homo sapiens_hsa04713	1.14487876
30	Endocytosis_Homo sapiens_hsa04144	1.11323266
31	Viral myocarditis_Homo sapiens_hsa05416	1.10101506
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06077045
33	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.05999556
34	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.03058870
35	Salivary secretion_Homo sapiens_hsa04970	1.01265806
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.00675673
37	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.00562931
38	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.96081118
39	Protein digestion and absorption_Homo sapiens_hsa04974	0.93868816
40	cAMP signaling pathway_Homo sapiens_hsa04024	0.92851007
41	Calcium signaling pathway_Homo sapiens_hsa04020	0.88953306
42	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84102668
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.83715864
44	PPAR signaling pathway_Homo sapiens_hsa03320	0.82525882
45	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.81818916
46	Cholinergic synapse_Homo sapiens_hsa04725	0.80148635
47	Serotonergic synapse_Homo sapiens_hsa04726	0.78942244
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78707107
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.78444860
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.78401438
51	Estrogen signaling pathway_Homo sapiens_hsa04915	0.77210973
52	Renin secretion_Homo sapiens_hsa04924	0.72307067
53	ABC transporters_Homo sapiens_hsa02010	0.71078104
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.70927383
55	Oocyte meiosis_Homo sapiens_hsa04114	0.70669545
56	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68506243
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.68361679
58	Retinol metabolism_Homo sapiens_hsa00830	0.68206903
59	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.66350742
60	Arginine biosynthesis_Homo sapiens_hsa00220	0.64268409
61	Gastric acid secretion_Homo sapiens_hsa04971	0.58394709
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.58167616
63	Influenza A_Homo sapiens_hsa05164	0.57577073
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57113231
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56669443
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.56604893
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55731137
68	GABAergic synapse_Homo sapiens_hsa04727	0.54051624
69	Renin-angiotensin system_Homo sapiens_hsa04614	0.53948221
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53821364
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.53799601
72	MAPK signaling pathway_Homo sapiens_hsa04010	0.52972579
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.51329514
74	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51105031
75	Insulin secretion_Homo sapiens_hsa04911	0.49752907
76	Basal transcription factors_Homo sapiens_hsa03022	0.47557982
77	Fanconi anemia pathway_Homo sapiens_hsa03460	0.45695012
78	Huntingtons disease_Homo sapiens_hsa05016	0.41057834
79	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.41027592
80	Purine metabolism_Homo sapiens_hsa00230	0.40639460
81	Pancreatic secretion_Homo sapiens_hsa04972	0.38081569
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.37796791
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.37747949
84	Bile secretion_Homo sapiens_hsa04976	0.36233140
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34219206
86	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33034164
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32953365
88	Tight junction_Homo sapiens_hsa04530	0.32296819
89	Notch signaling pathway_Homo sapiens_hsa04330	0.32015737
90	Long-term potentiation_Homo sapiens_hsa04720	0.30401729
91	Amphetamine addiction_Homo sapiens_hsa05031	0.30026369
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.26941400
93	Propanoate metabolism_Homo sapiens_hsa00640	0.26485712
94	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.23385153
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.23233247
96	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23161689
97	Metabolic pathways_Homo sapiens_hsa01100	0.22682248
98	VEGF signaling pathway_Homo sapiens_hsa04370	0.22647941
99	Lysine degradation_Homo sapiens_hsa00310	0.21382931
100	Cocaine addiction_Homo sapiens_hsa05030	0.18141571

C16ORF78

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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