ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	fusion of sperm to egg plasma membrane (GO:0007342)	8.69891130
2	multicellular organism reproduction (GO:0032504)	8.66118835
3	regulation of phosphoprotein phosphatase activity (GO:0043666)	8.60616630
4	binding of sperm to zona pellucida (GO:0007339)	8.51760793
5	sperm-egg recognition (GO:0035036)	7.93571534
6	axonemal dynein complex assembly (GO:0070286)	7.55952618
7	male meiosis (GO:0007140)	7.49081658
8	motile cilium assembly (GO:0044458)	7.17538710
9	reproduction (GO:0000003)	7.07121625
10	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.04607831
11	cell-cell recognition (GO:0009988)	6.77708518
12	plasma membrane fusion (GO:0045026)	6.69232920
13	sperm capacitation (GO:0048240)	6.60842682
14	protein-DNA complex disassembly (GO:0032986)	6.50814150
15	nucleosome disassembly (GO:0006337)	6.50814150
16	cilium or flagellum-dependent cell motility (GO:0001539)	6.46496150
17	positive regulation of catecholamine secretion (GO:0033605)	6.44328946
18	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.34240792
19	negative regulation of inclusion body assembly (GO:0090084)	6.27498670
20	calcium ion-dependent exocytosis (GO:0017156)	6.21546683
21	organic cation transport (GO:0015695)	5.99649066
22	polyamine biosynthetic process (GO:0006596)	5.97656890
23	microtubule depolymerization (GO:0007019)	5.92896636
24	single fertilization (GO:0007338)	5.92589413
25	phosphatidylethanolamine metabolic process (GO:0046337)	5.83569446
26	germ cell development (GO:0007281)	5.81791991
27	epithelial cilium movement (GO:0003351)	5.81644577
28	chromosome condensation (GO:0030261)	5.73603748
29	spermatid nucleus differentiation (GO:0007289)	5.70259668
30	DNA packaging (GO:0006323)	5.54349959
31	protein polyglutamylation (GO:0018095)	5.27743557
32	spermatogenesis (GO:0007283)	5.26646655
33	male gamete generation (GO:0048232)	5.24597516
34	cellular process involved in reproduction in multicellular organism (GO:0022412)	5.01254850
35	protein targeting to Golgi (GO:0000042)	4.89790909
36	cilium movement (GO:0003341)	4.85244958
37	response to acidic pH (GO:0010447)	4.84886846
38	gamete generation (GO:0007276)	4.84663365
39	rRNA methylation (GO:0031167)	4.82249674
40	single strand break repair (GO:0000012)	4.81976684
41	establishment of protein localization to Golgi (GO:0072600)	4.67350144
42	microtubule polymerization or depolymerization (GO:0031109)	4.55109587
43	coenzyme catabolic process (GO:0009109)	4.54813903
44	regulation of oxidative stress-induced neuron death (GO:1903203)	4.54161278
45	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.50248777
46	fertilization (GO:0009566)	4.50152922
47	microtubule severing (GO:0051013)	4.47290188
48	male sex determination (GO:0030238)	4.41397501
49	potassium ion export (GO:0071435)	4.30668094
50	ventricular system development (GO:0021591)	4.29868902
51	relaxation of smooth muscle (GO:0044557)	4.28608067
52	regulation of inclusion body assembly (GO:0090083)	4.27825834
53	centriole assembly (GO:0098534)	4.25475192
54	synapsis (GO:0007129)	4.20846241
55	histone exchange (GO:0043486)	4.11066005
56	regulation of oxidative phosphorylation (GO:0002082)	4.07714793
57	response to pheromone (GO:0019236)	4.05908591
58	regulation of cilium movement (GO:0003352)	4.03986130
59	Leydig cell differentiation (GO:0033327)	4.01190373
60	cellular biogenic amine biosynthetic process (GO:0042401)	3.97210829
61	rRNA modification (GO:0000154)	3.94342895
62	multicellular organismal reproductive process (GO:0048609)	3.93513862
63	positive regulation of glycolytic process (GO:0045821)	3.90959856
64	amine biosynthetic process (GO:0009309)	3.85986664
65	mitochondrion degradation (GO:0000422)	3.84077564
66	activation of protein kinase B activity (GO:0032148)	3.83017715
67	sexual reproduction (GO:0019953)	3.81846297
68	cellular response to pH (GO:0071467)	3.79150319
69	histone H3-K9 demethylation (GO:0033169)	3.74821092
70	cGMP-mediated signaling (GO:0019934)	3.74264977
71	cellular ketone body metabolic process (GO:0046950)	3.72927805
72	acrosome assembly (GO:0001675)	3.52264014
73	centriole replication (GO:0007099)	3.51113824
74	regulation of Rab GTPase activity (GO:0032313)	3.48694946
75	positive regulation of Rab GTPase activity (GO:0032851)	3.48694946
76	protein localization to Golgi apparatus (GO:0034067)	3.43144953
77	protein polymerization (GO:0051258)	3.40720308
78	regulation of transcription involved in cell fate commitment (GO:0060850)	3.39107148
79	regulation of dopamine secretion (GO:0014059)	3.36010927
80	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.34450457
81	oogenesis (GO:0048477)	3.34272008
82	polyamine metabolic process (GO:0006595)	3.31936389
83	cell recognition (GO:0008037)	3.31849751
84	regulation of phosphatase activity (GO:0010921)	3.31481963
85	ketone body metabolic process (GO:1902224)	3.27637507
86	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.27484810
87	meiotic nuclear division (GO:0007126)	3.26014128
88	glutamine family amino acid catabolic process (GO:0009065)	3.24417971
89	chromosome organization involved in meiosis (GO:0070192)	3.19740479
90	regulation of ARF GTPase activity (GO:0032312)	3.19725620
91	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.13714509
92	piRNA metabolic process (GO:0034587)	3.11234047
93	cranial nerve morphogenesis (GO:0021602)	3.07381804
94	negative regulation of response to reactive oxygen species (GO:1901032)	3.03151661
95	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.01921905
96	regulation of autophagic vacuole assembly (GO:2000785)	2.96768010
97	TOR signaling (GO:0031929)	2.93317548
98	acrosome reaction (GO:0007340)	12.4217779
99	sperm motility (GO:0030317)	12.0921532
100	spermatid development (GO:0007286)	10.2142215

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	8.02936447
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.03814775
3	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.16137220
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.05869863
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.99730199
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.89338051
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.71085666
8	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.52119985
9	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.52119985
10	FUS_26573619_Chip-Seq_HEK293_Human	2.41856506
11	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.33249221
12	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.25168296
13	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.21311806
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18257107
15	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.09049521
16	CBP_20019798_ChIP-Seq_JUKART_Human	2.09049521
17	NANOG_20526341_ChIP-Seq_ESCs_Human	2.01902437
18	RAC3_21632823_ChIP-Seq_H3396_Human	1.90456532
19	CTCF_27219007_Chip-Seq_Bcells_Human	1.84608668
20	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.80004091
21	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.78557808
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.77709765
23	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.72879430
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65694867
25	* ERA_21632823_ChIP-Seq_H3396_Human	1.65348837
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.64622444
27	SMC4_20622854_ChIP-Seq_HELA_Human	1.63883075
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.63469729
29	OCT4_20526341_ChIP-Seq_ESCs_Human	1.60898456
30	MYC_19829295_ChIP-Seq_ESCs_Human	1.57373585
31	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.56546378
32	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.54787171
33	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.52231424
34	ERG_20517297_ChIP-Seq_VCAP_Human	1.51211359
35	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.50066653
36	TP53_18474530_ChIP-ChIP_U2OS_Human	1.49782911
37	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.46450146
38	TBL1_22424771_ChIP-Seq_293T_Human	1.43052525
39	GBX2_23144817_ChIP-Seq_PC3_Human	1.42591300
40	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.41425362
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.39242111
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36611880
43	P300_19829295_ChIP-Seq_ESCs_Human	1.35875274
44	CTCF_20526341_ChIP-Seq_ESCs_Human	1.34220023
45	AR_25329375_ChIP-Seq_VCAP_Human	1.32996021
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.28051303
47	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26121252
48	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25230198
49	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25217005
50	PHF8_20622854_ChIP-Seq_HELA_Human	1.20712590
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.18920679
52	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.18748199
53	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.18728805
54	P68_20966046_ChIP-Seq_HELA_Human	1.16915923
55	LXR_22292898_ChIP-Seq_THP-1_Human	1.14896776
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14284590
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14284590
58	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.13047338
59	BCL6_27268052_Chip-Seq_Bcells_Human	1.12725986
60	VDR_22108803_ChIP-Seq_LS180_Human	1.12127058
61	TP63_22573176_ChIP-Seq_HFKS_Human	1.11520181
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.11189899
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.10984762
64	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.10789786
65	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.10464708
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09466458
67	NFYB_21822215_ChIP-Seq_K562_Human	1.09191541
68	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08351778
69	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07796666
70	E2F1_20622854_ChIP-Seq_HELA_Human	1.07732088
71	SPI1_20517297_ChIP-Seq_HL60_Human	1.07640995
72	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06284380
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04802866
74	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04724964
75	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.03760135
76	* P300_27268052_Chip-Seq_Bcells_Human	1.03649260
77	PHF8_20622853_ChIP-Seq_HELA_Human	1.03444675
78	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.01492973
79	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.01267444
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00295627
81	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00106436
82	ETV1_20927104_ChIP-Seq_GIST48_Human	0.99608194
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99069668
84	BCOR_27268052_Chip-Seq_Bcells_Human	0.98999667
85	DROSHA_22980978_ChIP-Seq_HELA_Human	0.96496892
86	GF1_26923725_Chip-Seq_HPCs_Mouse	0.96410661
87	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94619143
88	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.94449353
89	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93779500
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.93090080
91	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.91284395
92	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.91175490
93	* STAT3_23295773_ChIP-Seq_U87_Human	0.90953520
94	NFYA_21822215_ChIP-Seq_K562_Human	0.90397528
95	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.89901481
96	BCAT_22108803_ChIP-Seq_LS180_Human	0.88580771
97	* PRDM14_20953172_ChIP-Seq_ESCs_Human	0.88152540
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87967587
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.86740721
100	RXR_22108803_ChIP-Seq_LS180_Human	0.85050859

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003315_abnormal_perineum_morphology	4.64112865
2	MP0003698_abnormal_male_reproductive	4.48393399
3	MP0008004_abnormal_stomach_pH	4.30747781
4	MP0001929_abnormal_gametogenesis	3.96400276
5	MP0005377_hearing/vestibular/ear_phenot	3.12255049
6	MP0003878_abnormal_ear_physiology	3.12255049
7	MP0005360_urolithiasis	2.51149881
8	MP0002132_abnormal_respiratory_system	2.50990267
9	MP0005670_abnormal_white_adipose	2.50404958
10	MP0002161_abnormal_fertility/fecundity	2.42533424
11	MP0002160_abnormal_reproductive_system	2.42247856
12	MP0005410_abnormal_fertilization	12.7383733
13	MP0002210_abnormal_sex_determination	1.99796896
14	MP0003045_fibrosis	1.92041755
15	MP0003718_maternal_effect	1.86647125
16	MP0001984_abnormal_olfaction	1.86105173
17	MP0001145_abnormal_male_reproductive	1.75217098
18	MP0005647_abnormal_sex_gland	1.74775410
19	MP0000653_abnormal_sex_gland	1.60471048
20	MP0010386_abnormal_urinary_bladder	1.57737371
21	MP0000678_abnormal_parathyroid_gland	1.56231601
22	MP0003136_yellow_coat_color	1.44797160
23	MP0001905_abnormal_dopamine_level	1.43523863
24	MP0005499_abnormal_olfactory_system	1.37362816
25	MP0005394_taste/olfaction_phenotype	1.37362816
26	MP0008995_early_reproductive_senescence	1.29142386
27	MP0010368_abnormal_lymphatic_system	1.29056093
28	MP0005058_abnormal_lysosome_morphology	1.28724305
29	MP0001664_abnormal_digestion	1.27111814
30	MP0002249_abnormal_larynx_morphology	1.23059027
31	MP0009697_abnormal_copulation	1.20661071
32	MP0005395_other_phenotype	1.19947241
33	MP0000537_abnormal_urethra_morphology	1.19547171
34	MP0001348_abnormal_lacrimal_gland	1.17523550
35	MP0002127_abnormal_cardiovascular_syste	1.16185380
36	MP0005248_abnormal_Harderian_gland	1.12848086
37	MP0001485_abnormal_pinna_reflex	1.12648657
38	MP0005389_reproductive_system_phenotype	1.10751675
39	MP0003879_abnormal_hair_cell	1.06163919
40	MP0000538_abnormal_urinary_bladder	1.04630330
41	MP0001188_hyperpigmentation	1.01581082
42	MP0003646_muscle_fatigue	0.98186895
43	MP0005187_abnormal_penis_morphology	0.95137620
44	MP0001486_abnormal_startle_reflex	0.93340033
45	MP0002282_abnormal_trachea_morphology	0.92178404
46	MP0004085_abnormal_heartbeat	0.91368005
47	MP0004859_abnormal_synaptic_plasticity	0.90513381
48	MP0003632_abnormal_nervous_system	0.90170626
49	MP0005253_abnormal_eye_physiology	0.88982079
50	MP0001501_abnormal_sleep_pattern	0.85143494
51	MP0006072_abnormal_retinal_apoptosis	0.84234070
52	MP0003936_abnormal_reproductive_system	0.81827123
53	MP0002822_catalepsy	0.80635881
54	MP0002138_abnormal_hepatobiliary_system	0.79730954
55	MP0001963_abnormal_hearing_physiology	0.77859113
56	MP0003631_nervous_system_phenotype	0.77168835
57	MP0001968_abnormal_touch/_nociception	0.76617640
58	MP0002168_other_aberrant_phenotype	0.75656055
59	MP0000470_abnormal_stomach_morphology	0.75544997
60	MP0001849_ear_inflammation	0.73082250
61	MP0004084_abnormal_cardiac_muscle	0.72586100
62	MP0000026_abnormal_inner_ear	0.72240239
63	MP0005423_abnormal_somatic_nervous	0.66520216
64	MP0000534_abnormal_ureter_morphology	0.66012558
65	MP0004036_abnormal_muscle_relaxation	0.64096976
66	MP0004742_abnormal_vestibular_system	0.64070831
67	MP0005551_abnormal_eye_electrophysiolog	0.63261569
68	MP0002272_abnormal_nervous_system	0.61696108
69	MP0000230_abnormal_systemic_arterial	0.59394128
70	MP0000049_abnormal_middle_ear	0.58281453
71	MP0001270_distended_abdomen	0.55568742
72	MP0005646_abnormal_pituitary_gland	0.55298078
73	MP0005451_abnormal_body_composition	0.55239619
74	MP0005409_darkened_coat_color	0.55231044
75	MP0003633_abnormal_nervous_system	0.55173231
76	MP0009115_abnormal_fat_cell	0.55150293
77	MP0008789_abnormal_olfactory_epithelium	0.54684144
78	MP0001765_abnormal_ion_homeostasis	0.53769049
79	MP0006036_abnormal_mitochondrial_physio	0.52941336
80	MP0001919_abnormal_reproductive_system	0.52837458
81	MP0002067_abnormal_sensory_capabilities	0.52589359
82	MP0000681_abnormal_thyroid_gland	0.52312495
83	MP0002229_neurodegeneration	0.51763263
84	MP0005595_abnormal_vascular_smooth	0.51749060
85	MP0000465_gastrointestinal_hemorrhage	0.48084963
86	MP0001529_abnormal_vocalization	0.47847308
87	MP0004484_altered_response_of	0.47726362
88	MP0000955_abnormal_spinal_cord	0.46443262
89	MP0002735_abnormal_chemical_nociception	0.46287761
90	MP0000343_altered_response_to	0.45959796
91	MP0003635_abnormal_synaptic_transmissio	0.45747437
92	MP0003011_delayed_dark_adaptation	0.45575946
93	MP0008877_abnormal_DNA_methylation	0.43526144
94	MP0005379_endocrine/exocrine_gland_phen	0.43488315
95	MP0005391_vision/eye_phenotype	0.43122590
96	MP0002557_abnormal_social/conspecific_i	0.42687442
97	MP0005166_decreased_susceptibility_to	0.40490453
98	MP0000631_abnormal_neuroendocrine_gland	0.39131476
99	MP0005167_abnormal_blood-brain_barrier	0.37227225
100	MP0002572_abnormal_emotion/affect_behav	0.37190635

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Resting tremor (HP:0002322)	7.74804251
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.04858946
3	Absent/shortened dynein arms (HP:0200106)	7.04858946
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.59027707
5	Abnormal respiratory motile cilium physiology (HP:0012261)	6.18380689
6	Abnormal ciliary motility (HP:0012262)	6.03545426
7	Sex reversal (HP:0012245)	5.95129698
8	Abnormal sex determination (HP:0012244)	5.95129698
9	Infertility (HP:0000789)	5.35426174
10	Abnormal respiratory epithelium morphology (HP:0012253)	5.24351140
11	Abnormal respiratory motile cilium morphology (HP:0005938)	5.24351140
12	Hypoplasia of the uterus (HP:0000013)	5.12577697
13	Postural instability (HP:0002172)	4.94469508
14	Tubulointerstitial nephritis (HP:0001970)	4.42526557
15	Nasal polyposis (HP:0100582)	4.41178242
16	Severe visual impairment (HP:0001141)	4.30176281
17	Gonadal dysgenesis (HP:0000133)	4.07004892
18	Aplasia/hypoplasia of the uterus (HP:0008684)	3.84090837
19	Abnormality of the columella (HP:0009929)	3.80298121
20	Colitis (HP:0002583)	3.79282244
21	Chronic hepatic failure (HP:0100626)	3.79033527
22	Abnormality of the nasal mucosa (HP:0000433)	3.75203378
23	Rhinitis (HP:0012384)	3.62237287
24	Male pseudohermaphroditism (HP:0000037)	3.49898745
25	Cerebellar dysplasia (HP:0007033)	3.41903700
26	Reduced antithrombin III activity (HP:0001976)	3.41642543
27	Bony spicule pigmentary retinopathy (HP:0007737)	3.36117482
28	Abnormality of macular pigmentation (HP:0008002)	3.29245570
29	Germ cell neoplasia (HP:0100728)	3.27923097
30	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.21351103
31	Attenuation of retinal blood vessels (HP:0007843)	3.18993336
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.95194758
33	Ventricular fibrillation (HP:0001663)	2.95047302
34	Type II lissencephaly (HP:0007260)	2.89310611
35	Male infertility (HP:0003251)	2.83561448
36	Chronic bronchitis (HP:0004469)	2.81798562
37	Asymmetric septal hypertrophy (HP:0001670)	2.75236727
38	Occipital encephalocele (HP:0002085)	2.68586184
39	Facial hemangioma (HP:0000329)	2.66669855
40	Bronchiectasis (HP:0002110)	2.66372606
41	Atonic seizures (HP:0010819)	2.65841153
42	Thoracolumbar scoliosis (HP:0002944)	2.62585249
43	Congenital sensorineural hearing impairment (HP:0008527)	2.61618679
44	Hyperkalemia (HP:0002153)	2.58679221
45	Retinal atrophy (HP:0001105)	2.56925514
46	Retinal dysplasia (HP:0007973)	2.52874687
47	Sensory axonal neuropathy (HP:0003390)	2.50004046
48	Renal dysplasia (HP:0000110)	2.47434297
49	Impulsivity (HP:0100710)	2.46220747
50	Bell-shaped thorax (HP:0001591)	2.45800785
51	Self-mutilation (HP:0000742)	2.45202869
52	Inflammation of the large intestine (HP:0002037)	2.33921112
53	Thoracic kyphosis (HP:0002942)	2.33419163
54	Anterior segment dysgenesis (HP:0007700)	2.28470245
55	Urinary urgency (HP:0000012)	2.27128079
56	Flattened epiphyses (HP:0003071)	2.24010165
57	Optic nerve hypoplasia (HP:0000609)	2.22611951
58	Facial shape deformation (HP:0011334)	2.18772987
59	Potter facies (HP:0002009)	2.18772987
60	Abnormal drinking behavior (HP:0030082)	2.18711824
61	Polydipsia (HP:0001959)	2.18711824
62	Cone-rod dystrophy (HP:0000548)	2.18505516
63	Azoospermia (HP:0000027)	2.15060495
64	Gastrointestinal inflammation (HP:0004386)	2.10861728
65	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.10231690
66	Abnormality of dental color (HP:0011073)	2.09800519
67	Hypoplasia of the thymus (HP:0000778)	2.06698848
68	Abnormal urine output (HP:0012590)	1.99044561
69	Abnormal spermatogenesis (HP:0008669)	1.98983260
70	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.98695703
71	Hypoalphalipoproteinemia (HP:0003233)	1.98202824
72	Buphthalmos (HP:0000557)	1.94820287
73	Protruding tongue (HP:0010808)	1.88530903
74	Renovascular hypertension (HP:0100817)	1.87819851
75	Abnormality of the lumbar spine (HP:0100712)	1.86775550
76	Recurrent corneal erosions (HP:0000495)	1.84680644
77	Hypoplastic ischia (HP:0003175)	1.83050422
78	Progressive sensorineural hearing impairment (HP:0000408)	1.76734682
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76571263
80	Tubulointerstitial abnormality (HP:0001969)	1.76507703
81	Atrial fibrillation (HP:0005110)	1.76413392
82	Chronic sinusitis (HP:0011109)	1.74835342
83	Menstrual irregularities (HP:0000858)	1.74166220
84	Inability to walk (HP:0002540)	1.73873932
85	Abnormality of the intrinsic pathway (HP:0010989)	1.73153610
86	Truncal obesity (HP:0001956)	1.72930812
87	Abnormality of the ischium (HP:0003174)	1.71586705
88	Bradykinesia (HP:0002067)	1.71351139
89	Abnormality of male internal genitalia (HP:0000022)	1.71233621
90	Polyuria (HP:0000103)	1.70971856
91	Abnormality of renal excretion (HP:0011036)	1.68856981
92	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.67923297
93	Photophobia (HP:0000613)	1.67715347
94	Rhabdomyolysis (HP:0003201)	1.66128933
95	Progressive cerebellar ataxia (HP:0002073)	1.65790474
96	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.64947911
97	Capillary hemangiomas (HP:0005306)	1.64926550
98	Type II diabetes mellitus (HP:0005978)	1.64430517
99	Absent thumb (HP:0009777)	1.59416668
100	Primary atrial arrhythmia (HP:0001692)	1.58927681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	5.17887438
2	PLK4	4.25977271
3	TLK1	3.23703272
4	ZAK	3.22009628
5	STK38	3.00632241
6	MYLK	2.65199357
7	RPS6KA5	2.36763613
8	STK38L	2.29272230
9	TESK1	2.26756232
10	PINK1	10.1869020
11	LATS1	1.94137434
12	NEK2	1.93677703
13	MAPK15	1.92732006
14	DDR2	1.90089145
15	INSRR	1.74540379
16	MST1R	1.73633152
17	BRD4	1.58037406
18	PRKD3	1.46631043
19	PNCK	1.38707974
20	PLK2	1.34204856
21	MAP4K2	1.25298943
22	CAMK1G	1.22265525
23	CDK3	1.21947882
24	LATS2	1.20741278
25	MAP3K9	1.14865492
26	SGK223	1.12278089
27	SGK494	1.12278089
28	MAP2K7	1.08525689
29	PDPK1	1.07565470
30	PDK1	0.92685174
31	FRK	0.80550541
32	BMPR1B	0.79249895
33	ARAF	0.79241287
34	PTK2B	0.78819543
35	CDK12	0.78063530
36	WNK1	0.75527597
37	PIK3CG	0.73286672
38	PRKCQ	0.71697350
39	PRKG2	0.71147614
40	DYRK3	0.68535530
41	MAP3K1	0.65862240
42	VRK1	0.65042843
43	ROCK1	0.60814148
44	CDK14	0.60456515
45	NEK6	0.59266491
46	CAMK1	0.59006492
47	TIE1	0.56784459
48	PRKG1	0.56542538
49	BRAF	0.54210102
50	OBSCN	0.52530503
51	CDC42BPA	0.50089079
52	KSR2	0.49299656
53	AKT3	0.48010497
54	MAP3K13	0.46494379
55	TYRO3	0.46244092
56	CSNK1A1L	0.45268704
57	PKN1	0.44823500
58	RPS6KA1	0.44643905
59	FGFR2	0.42894885
60	PAK2	0.41337856
61	PAK1	0.41072187
62	CDK7	0.40417418
63	DYRK2	0.39858088
64	CAMK1D	0.39125645
65	DYRK1B	0.35599304
66	MTOR	0.34934421
67	CSNK1G3	0.32638495
68	CDK5	0.32235124
69	MAPK1	0.30221259
70	SGK2	0.27249541
71	RPS6KA2	0.26332940
72	SIK2	0.24166257
73	ATM	0.23870838
74	MET	0.23128774
75	RET	0.21990607
76	ADRBK2	0.21623862
77	GSK3B	0.21292361
78	FGR	0.20911391
79	MOS	0.20601367
80	EGFR	0.20363537
81	MELK	0.19126638
82	ICK	0.18350167
83	CSNK1G1	0.17978904
84	CSNK1G2	0.17864086
85	MAP3K2	0.17346939
86	TGFBR1	0.16928924
87	MAP3K8	0.16804273
88	RPS6KA3	0.16441345
89	CSNK1A1	0.15718032
90	DAPK3	0.15299621
91	CDK1	0.14041791
92	MINK1	0.13458785
93	CAMK4	0.12996886
94	STK39	0.12925829
95	WNK4	0.12738558
96	SGK1	0.12220658
97	RPS6KB1	0.12152987
98	PRKAA2	0.11892879
99	EEF2K	0.10263098
100	MAP3K10	0.10087900

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	6.22809566
2	Gap junction_Homo sapiens_hsa04540	4.41437605
3	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.13619443
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.97806358
5	Olfactory transduction_Homo sapiens_hsa04740	3.24060592
6	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.16346971
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.89139045
8	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.59780946
9	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.55597107
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.49692276
11	Butanoate metabolism_Homo sapiens_hsa00650	2.42604365
12	Phagosome_Homo sapiens_hsa04145	2.28584720
13	Apoptosis_Homo sapiens_hsa04210	2.26163606
14	Alcoholism_Homo sapiens_hsa05034	2.04650776
15	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.93996801
16	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.87129482
17	Propanoate metabolism_Homo sapiens_hsa00640	1.61610092
18	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.36906015
19	Phenylalanine metabolism_Homo sapiens_hsa00360	1.35892983
20	Fatty acid degradation_Homo sapiens_hsa00071	1.35169903
21	Taste transduction_Homo sapiens_hsa04742	1.34644162
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.15446233
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09487867
24	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.00313310
25	Oocyte meiosis_Homo sapiens_hsa04114	0.99233864
26	Pyruvate metabolism_Homo sapiens_hsa00620	0.99066910
27	Glutathione metabolism_Homo sapiens_hsa00480	0.96524254
28	Fatty acid metabolism_Homo sapiens_hsa01212	0.95472193
29	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.95401931
30	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.94163012
31	RNA transport_Homo sapiens_hsa03013	0.87406920
32	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.84866260
33	Renin secretion_Homo sapiens_hsa04924	0.83545320
34	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.78515406
35	Glucagon signaling pathway_Homo sapiens_hsa04922	0.78350457
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74633674
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.71933596
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69416797
39	Calcium signaling pathway_Homo sapiens_hsa04020	0.67040787
40	Gastric acid secretion_Homo sapiens_hsa04971	0.66050785
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.64922271
42	Tyrosine metabolism_Homo sapiens_hsa00350	0.61590736
43	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.61198484
44	Type II diabetes mellitus_Homo sapiens_hsa04930	0.61134884
45	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.60923069
46	mRNA surveillance pathway_Homo sapiens_hsa03015	0.57149110
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.55344149
48	Circadian entrainment_Homo sapiens_hsa04713	0.55089186
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54988712
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.51629458
51	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50813465
52	Purine metabolism_Homo sapiens_hsa00230	0.50515983
53	Basal transcription factors_Homo sapiens_hsa03022	0.50368565
54	Estrogen signaling pathway_Homo sapiens_hsa04915	0.49130264
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48003543
56	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.47429858
57	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.46587375
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.45683687
59	Arginine and proline metabolism_Homo sapiens_hsa00330	0.44595343
60	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.44324338
61	Circadian rhythm_Homo sapiens_hsa04710	0.44122165
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.43669977
63	Phototransduction_Homo sapiens_hsa04744	0.43270289
64	Salivary secretion_Homo sapiens_hsa04970	0.42652739
65	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41260913
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.40622611
67	cAMP signaling pathway_Homo sapiens_hsa04024	0.38672531
68	Protein digestion and absorption_Homo sapiens_hsa04974	0.37674712
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.36787030
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35554258
71	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.35230550
72	Fanconi anemia pathway_Homo sapiens_hsa03460	0.34896636
73	MAPK signaling pathway_Homo sapiens_hsa04010	0.33808334
74	Long-term potentiation_Homo sapiens_hsa04720	0.32372943
75	Retinol metabolism_Homo sapiens_hsa00830	0.31466524
76	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.30741420
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30228661
78	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.29343960
79	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.28699464
80	Endocytosis_Homo sapiens_hsa04144	0.27501720
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27231137
82	Choline metabolism in cancer_Homo sapiens_hsa05231	0.26960494
83	ECM-receptor interaction_Homo sapiens_hsa04512	0.26018747
84	Morphine addiction_Homo sapiens_hsa05032	0.25646652
85	VEGF signaling pathway_Homo sapiens_hsa04370	0.25449668
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.25418688
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.24837994
88	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.22795702
89	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.22406849
90	Nicotine addiction_Homo sapiens_hsa05033	0.22193426
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.22136103
92	Influenza A_Homo sapiens_hsa05164	0.21784937
93	Tight junction_Homo sapiens_hsa04530	0.21591704
94	Carbon metabolism_Homo sapiens_hsa01200	0.21571886
95	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.21500104
96	Metabolic pathways_Homo sapiens_hsa01100	0.21028187
97	Viral carcinogenesis_Homo sapiens_hsa05203	0.20520738
98	Prostate cancer_Homo sapiens_hsa05215	0.20496905
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.18857412
100	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.18203631

C16ORF82

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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