C16ORF86

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.80446852
2modulation by symbiont of host defense response (GO:0052031)5.80446852
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.80446852
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.80446852
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.80446852
6modulation by symbiont of host immune response (GO:0052553)5.80446852
7antigen processing and presentation of endogenous antigen (GO:0019883)5.52098777
8immunoglobulin mediated immune response (GO:0016064)5.38770661
9regulation of interferon-beta biosynthetic process (GO:0045357)4.87982250
10NIK/NF-kappaB signaling (GO:0038061)4.77014526
11macrophage activation involved in immune response (GO:0002281)4.63823307
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.49808893
13positive regulation of gamma-delta T cell activation (GO:0046645)4.44089611
14detection of bacterium (GO:0016045)4.39138860
15positive thymic T cell selection (GO:0045059)4.38640071
16response to host immune response (GO:0052572)4.36458185
17response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.36458185
18negative regulation of erythrocyte differentiation (GO:0045647)4.32564000
19B cell mediated immunity (GO:0019724)4.22496252
20detection of other organism (GO:0098543)4.19372404
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16311637
22negative regulation of cell killing (GO:0031342)4.11636685
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.11636685
24regulation of antigen processing and presentation (GO:0002577)3.91788113
25response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91031818
26response to host (GO:0075136)3.91031818
27response to host defenses (GO:0052200)3.91031818
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84767212
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.81308816
30B cell receptor signaling pathway (GO:0050853)3.75904321
31regulation of B cell receptor signaling pathway (GO:0050855)3.71637581
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.69456439
33neutrophil activation involved in immune response (GO:0002283)3.58627091
34positive regulation of antigen processing and presentation (GO:0002579)3.54278892
35positive regulation of macrophage cytokine production (GO:0060907)3.53675257
36microglial cell activation (GO:0001774)3.51447282
37regulation of B cell apoptotic process (GO:0002902)3.46865270
38negative regulation of B cell apoptotic process (GO:0002903)3.44061734
39positive regulation of B cell differentiation (GO:0045579)3.40207555
40regulation of mast cell degranulation (GO:0043304)3.39770527
41mature B cell differentiation involved in immune response (GO:0002313)3.38514974
42mucosal-associated lymphoid tissue development (GO:0048537)3.37002715
43Peyers patch development (GO:0048541)3.37002715
44detection of external biotic stimulus (GO:0098581)3.34994876
45positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.29085503
46interferon-gamma-mediated signaling pathway (GO:0060333)3.22549343
47myeloid cell activation involved in immune response (GO:0002275)3.21069269
48chaperone mediated protein folding requiring cofactor (GO:0051085)3.12483182
49response to peptidoglycan (GO:0032494)3.11815880
50negative thymic T cell selection (GO:0045060)3.09101058
51macrophage activation (GO:0042116)3.06633632
52negative regulation of myeloid cell apoptotic process (GO:0033033)3.06043605
53mannose metabolic process (GO:0006013)3.04735904
54positive regulation of type 2 immune response (GO:0002830)3.04298892
55regulation of macrophage cytokine production (GO:0010935)3.03008893
56negative regulation of phagocytosis (GO:0050765)2.99731014
57regulation of mast cell activation involved in immune response (GO:0033006)2.98449595
58regulation of myeloid leukocyte mediated immunity (GO:0002886)2.98448108
59regulation of B cell differentiation (GO:0045577)2.95996159
60positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.93745774
61mature B cell differentiation (GO:0002335)2.93394002
62positive T cell selection (GO:0043368)2.92112850
63negative regulation of interleukin-12 production (GO:0032695)2.87710332
64regulation of leukocyte degranulation (GO:0043300)2.86872055
65actin filament polymerization (GO:0030041)2.86613165
66detection of biotic stimulus (GO:0009595)2.85266033
67I-kappaB phosphorylation (GO:0007252)2.84869989
68negative regulation of lymphocyte mediated immunity (GO:0002707)2.83886295
69negative regulation of leukocyte mediated immunity (GO:0002704)2.82679254
70regulation of gamma-delta T cell activation (GO:0046643)2.81605567
71regulation of type 2 immune response (GO:0002828)2.79934505
72pinocytosis (GO:0006907)2.78645182
73negative T cell selection (GO:0043383)2.77858365
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.74487292
75negative regulation of innate immune response (GO:0045824)2.72766309
76respiratory burst (GO:0045730)2.72094250
77thymic T cell selection (GO:0045061)2.71381597
78negative regulation of type 2 immune response (GO:0002829)2.70492046
79defense response to protozoan (GO:0042832)2.66230058
80leukocyte aggregation (GO:0070486)2.65780239
81regulation of mast cell activation (GO:0033003)2.65721336
82positive regulation of interferon-alpha production (GO:0032727)2.65683314
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.64305872
84cellular hyperosmotic response (GO:0071474)2.64166379
85cellular response to type I interferon (GO:0071357)2.62457880
86type I interferon signaling pathway (GO:0060337)2.62457880
87regulation of superoxide anion generation (GO:0032928)2.60975670
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59498595
89regulation of monocyte differentiation (GO:0045655)2.59344271
90positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.59310667
91positive regulation of mast cell activation (GO:0033005)2.58576820
92histone H3-K36 demethylation (GO:0070544)2.57265913
93response to type I interferon (GO:0034340)2.56959587
94T cell selection (GO:0045058)2.56371827
95negative regulation of cytokine production involved in immune response (GO:0002719)2.56084754
96positive regulation of interferon-beta production (GO:0032728)2.53853481
97regulation of interferon-gamma biosynthetic process (GO:0045072)2.52447386
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.52121513
99positive regulation of lipoprotein lipase activity (GO:0051006)2.51871299
100positive regulation of triglyceride lipase activity (GO:0061365)2.51871299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.14973315
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.80411794
3VDR_21846776_ChIP-Seq_THP-1_Human3.37915637
4MYC_22102868_ChIP-Seq_BL_Human2.89616429
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.73311869
6LXR_22292898_ChIP-Seq_THP-1_Human2.69513576
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59277343
8VDR_24763502_ChIP-Seq_THP-1_Human2.42850811
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.38201665
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36340884
11E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.34807597
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31384437
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25533721
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24843605
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.12324692
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11807018
17MAF_26560356_Chip-Seq_TH1_Human2.04062179
18UTX_26944678_Chip-Seq_JUKART_Human2.00773429
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00673554
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99299003
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.95014954
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.90126132
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.84931856
24MAF_26560356_Chip-Seq_TH2_Human1.84656252
25KDM2B_26808549_Chip-Seq_DND41_Human1.83807408
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.82805601
27BCL6_27268052_Chip-Seq_Bcells_Human1.80538133
28TCF7_22412390_ChIP-Seq_EML_Mouse1.79518389
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.79258411
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74855608
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74325435
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.73017790
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70320458
34P68_20966046_ChIP-Seq_HELA_Human1.69702111
35LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.69424964
36CIITA_25753668_ChIP-Seq_RAJI_Human1.68316697
37SPI1_23547873_ChIP-Seq_NB4_Human1.65140079
38SPI1_23127762_ChIP-Seq_K562_Human1.64612461
39BCOR_27268052_Chip-Seq_Bcells_Human1.62536758
40SCL_19346495_ChIP-Seq_HPC-7_Human1.61231133
41PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.56619839
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55870447
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.55211827
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53984948
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53557073
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.52933168
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52458062
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50637266
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.49431589
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48950313
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44996540
52PU.1_20513432_ChIP-Seq_Bcells_Mouse1.42814070
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.41005098
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40168285
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.37231015
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.35986907
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35463424
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34327493
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33950247
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32081086
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.30860808
62MYB_26560356_Chip-Seq_TH2_Human1.30560712
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30377157
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28488847
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26759285
66MYB_26560356_Chip-Seq_TH1_Human1.25813294
67CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25768522
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25341771
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23968064
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23171091
71SPI1_20517297_ChIP-Seq_HL60_Human1.22295216
72RUNX_20019798_ChIP-Seq_JUKART_Human1.21771231
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20164311
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19048177
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18604822
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.18374863
77E2F1_20622854_ChIP-Seq_HELA_Human1.16775386
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15872981
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15217812
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14927136
81* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14906067
82RACK7_27058665_Chip-Seq_MCF-7_Human1.13763482
83PHF8_20622854_ChIP-Seq_HELA_Human1.11568433
84EGR1_19374776_ChIP-ChIP_THP-1_Human1.11068756
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11064686
86SMC4_20622854_ChIP-Seq_HELA_Human1.10449701
87YY1_22570637_ChIP-Seq_MALME-3M_Human1.09783220
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09004330
89* CTCF_21964334_Chip-Seq_Bcells_Human1.08905468
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08407452
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08086716
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06947019
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.06629643
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05543719
95RXR_22158963_ChIP-Seq_LIVER_Mouse1.04883685
96NCOR1_26117541_ChIP-Seq_K562_Human1.04668733
97GATA1_19941826_ChIP-Seq_K562_Human1.04207900
98SA1_27219007_Chip-Seq_Bcells_Human1.03983049
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02820142
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02216727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.08815613
2MP0005058_abnormal_lysosome_morphology3.23609623
3MP0003436_decreased_susceptibility_to3.03038165
4MP0003303_peritoneal_inflammation2.92693426
5MP0005387_immune_system_phenotype2.80740218
6MP0001790_abnormal_immune_system2.80740218
7MP0003172_abnormal_lysosome_physiology2.78168806
8MP0002138_abnormal_hepatobiliary_system2.75430170
9MP0000685_abnormal_immune_system2.67969444
10MP0003724_increased_susceptibility_to2.65344584
11MP0001800_abnormal_humoral_immune2.62383052
12MP0005464_abnormal_platelet_physiology2.61161306
13MP0005000_abnormal_immune_tolerance2.54786137
14MP0005025_abnormal_response_to2.54108913
15MP0002419_abnormal_innate_immunity2.49569561
16MP0002452_abnormal_antigen_presenting2.30139120
17MP0009278_abnormal_bone_marrow2.29980700
18MP0002723_abnormal_immune_serum2.29760775
19MP0002148_abnormal_hypersensitivity_rea2.28575225
20MP0005671_abnormal_response_to2.23617229
21MP0002420_abnormal_adaptive_immunity2.14686648
22MP0001819_abnormal_immune_cell2.12299376
23MP0009785_altered_susceptibility_to2.01287468
24MP0009840_abnormal_foam_cell1.95958711
25MP0003183_abnormal_peptide_metabolism1.91373856
26MP0003191_abnormal_cellular_cholesterol1.91178035
27MP0002132_abnormal_respiratory_system1.82922985
28MP0006082_CNS_inflammation1.82482995
29MP0003300_gastrointestinal_ulcer1.67574233
30MP0001545_abnormal_hematopoietic_system1.67259285
31MP0005397_hematopoietic_system_phenotyp1.67259285
32MP0002396_abnormal_hematopoietic_system1.67035540
33MP0000604_amyloidosis1.66369193
34MP0000716_abnormal_immune_system1.66332765
35MP0002398_abnormal_bone_marrow1.66251966
36MP0003075_altered_response_to1.66080331
37MP0000465_gastrointestinal_hemorrhage1.65662629
38MP0002405_respiratory_system_inflammati1.63937410
39MP0000689_abnormal_spleen_morphology1.62180119
40MP0003763_abnormal_thymus_physiology1.60509313
41MP0005451_abnormal_body_composition1.58180427
42MP0003806_abnormal_nucleotide_metabolis1.55126525
43MP0008260_abnormal_autophagy1.52830790
44MP0004510_myositis1.52118499
45MP0001533_abnormal_skeleton_physiology1.43308359
46MP0008469_abnormal_protein_level1.42177325
47MP0001845_abnormal_inflammatory_respons1.41273735
48MP0002429_abnormal_blood_cell1.37833535
49MP0009333_abnormal_splenocyte_physiolog1.37256415
50MP0002722_abnormal_immune_system1.32111662
51MP0002139_abnormal_hepatobiliary_system1.26548402
52MP0010155_abnormal_intestine_physiology1.20672146
53MP0000343_altered_response_to1.19718331
54MP0005310_abnormal_salivary_gland1.18678810
55MP0002653_abnormal_ependyma_morphology1.18558550
56MP0003329_amyloid_beta_deposits1.13932219
57MP0002933_joint_inflammation1.08942998
58MP0003690_abnormal_glial_cell1.06780000
59MP0003866_abnormal_defecation1.06577953
60MP0002998_abnormal_bone_remodeling1.05019271
61MP0005365_abnormal_bile_salt1.03301560
62MP0002166_altered_tumor_susceptibility1.02527627
63MP0005645_abnormal_hypothalamus_physiol0.99526958
64MP0005166_decreased_susceptibility_to0.98780853
65MP0000015_abnormal_ear_pigmentation0.98294841
66MP0006036_abnormal_mitochondrial_physio0.96874048
67MP0004947_skin_inflammation0.93456791
68MP0004808_abnormal_hematopoietic_stem0.91736180
69MP0001853_heart_inflammation0.91664680
70MP0000372_irregular_coat_pigmentation0.90497986
71MP0003279_aneurysm0.88849940
72MP0000858_altered_metastatic_potential0.87457268
73MP0002638_abnormal_pupillary_reflex0.86274752
74MP0000490_abnormal_crypts_of0.84810385
75MP0001873_stomach_inflammation0.84644342
76MP0009764_decreased_sensitivity_to0.83885193
77MP0003879_abnormal_hair_cell0.83546251
78MP0001661_extended_life_span0.82411441
79MP0005075_abnormal_melanosome_morpholog0.80566763
80MP0009763_increased_sensitivity_to0.80393290
81MP0005584_abnormal_enzyme/coenzyme_acti0.79924037
82MP0004145_abnormal_muscle_electrophysio0.79518089
83MP0000703_abnormal_thymus_morphology0.78454564
84MP0003828_pulmonary_edema0.78276045
85MP0001348_abnormal_lacrimal_gland0.77814057
86MP0008874_decreased_physiological_sensi0.74982146
87MP0000747_muscle_weakness0.71157071
88MP0000681_abnormal_thyroid_gland0.71001814
89MP0005319_abnormal_enzyme/_coenzyme0.70764475
90MP0001851_eye_inflammation0.69367303
91MP0001849_ear_inflammation0.68875547
92MP0001663_abnormal_digestive_system0.68803067
93MP0005165_increased_susceptibility_to0.68454925
94MP0002118_abnormal_lipid_homeostasis0.68371343
95MP0002971_abnormal_brown_adipose0.66135789
96MP0010329_abnormal_lipoprotein_level0.66047085
97MP0002009_preneoplasia0.63929618
98MP0004883_abnormal_blood_vessel0.63649306
99MP0000609_abnormal_liver_physiology0.63605759
100MP0000249_abnormal_blood_vessel0.63542565

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.47808716
2Agammaglobulinemia (HP:0004432)4.23711420
3Abnormality of macrophages (HP:0004311)4.10393222
4Cellulitis (HP:0100658)3.90605749
5Recurrent abscess formation (HP:0002722)3.71055719
6Mediastinal lymphadenopathy (HP:0100721)3.62214123
7Abnormality of liposaccharide metabolism (HP:0010968)3.61858114
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.61858114
9Abnormality of glycolipid metabolism (HP:0010969)3.61858114
10Recurrent bacterial skin infections (HP:0005406)3.60144916
11Recurrent gram-negative bacterial infections (HP:0005420)3.59422404
12Meningitis (HP:0001287)3.57613502
13Dysostosis multiplex (HP:0000943)3.51398476
14Prolonged bleeding time (HP:0003010)3.36920761
15Increased cerebral lipofuscin (HP:0011813)3.23756969
16Gastrointestinal stroma tumor (HP:0100723)3.20046020
17Obstructive lung disease (HP:0006536)3.17542049
18Chronic obstructive pulmonary disease (HP:0006510)3.17542049
19Stomatitis (HP:0010280)3.13968475
20Purpura (HP:0000979)3.13799100
21Petechiae (HP:0000967)3.10503180
22Colitis (HP:0002583)3.08704337
23Systemic lupus erythematosus (HP:0002725)2.96441348
24Gastrointestinal inflammation (HP:0004386)2.94564288
25Asymmetric septal hypertrophy (HP:0001670)2.89778337
26Rhabdomyolysis (HP:0003201)2.89527529
27Inflammation of the large intestine (HP:0002037)2.88680084
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.88228139
29Elevated erythrocyte sedimentation rate (HP:0003565)2.85921270
30Myositis (HP:0100614)2.84754706
31Visual hallucinations (HP:0002367)2.82071668
32Panhypogammaglobulinemia (HP:0003139)2.80259909
33Gingival bleeding (HP:0000225)2.74582119
34Epistaxis (HP:0000421)2.74054559
35Recurrent fungal infections (HP:0002841)2.71356072
36Exercise-induced myalgia (HP:0003738)2.70749560
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.69001614
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.60052609
39Fatigue (HP:0012378)2.54641185
40Abnormality of skeletal muscle fiber size (HP:0012084)2.52012019
41Loss of speech (HP:0002371)2.51853299
42Recurrent skin infections (HP:0001581)2.51534018
43Prolonged neonatal jaundice (HP:0006579)2.50136870
44Urticaria (HP:0001025)2.47502771
45Vacuolated lymphocytes (HP:0001922)2.45387289
46Progressive neurologic deterioration (HP:0002344)2.43976522
47Abnormality of polysaccharide metabolism (HP:0011012)2.43061895
48Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43061895
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43061895
50Papilloma (HP:0012740)2.41100396
51Verrucae (HP:0200043)2.41100396
52Mucopolysacchariduria (HP:0008155)2.38726873
53Urinary glycosaminoglycan excretion (HP:0003541)2.38726873
54Vasculitis (HP:0002633)2.36849517
55Recurrent viral infections (HP:0004429)2.36683632
56Global brain atrophy (HP:0002283)2.35918857
57Osteomyelitis (HP:0002754)2.35592024
58Increased variability in muscle fiber diameter (HP:0003557)2.35314686
59Episodic fever (HP:0001954)2.34475869
60Chest pain (HP:0100749)2.33714914
61Increased IgE level (HP:0003212)2.32458129
62Ragged-red muscle fibers (HP:0003200)2.32432840
63Hepatosplenomegaly (HP:0001433)2.31890884
64Orchitis (HP:0100796)2.31768532
65Encephalitis (HP:0002383)2.27668688
66Emphysema (HP:0002097)2.27093942
67Recurrent pneumonia (HP:0006532)2.25988130
68Easy fatigability (HP:0003388)2.25045115
69Recurrent bronchitis (HP:0002837)2.24755719
70Chronic mucocutaneous candidiasis (HP:0002728)2.20900582
71Recurrent cutaneous fungal infections (HP:0011370)2.20900582
72Muscle stiffness (HP:0003552)2.20340673
73Restrictive lung disease (HP:0002091)2.17839553
74Distal lower limb muscle weakness (HP:0009053)2.17303946
75Recurrent sinusitis (HP:0011108)2.13334059
76Recurrent lower respiratory tract infections (HP:0002783)2.11922596
77Sepsis (HP:0100806)2.10491532
78Thrombocytosis (HP:0001894)2.10060328
79Increased serum ferritin (HP:0003281)2.08089584
80Gastrointestinal infarctions (HP:0005244)2.05897313
81Lymphopenia (HP:0001888)2.05341355
82Amyloidosis (HP:0011034)2.03272876
83Neuronal loss in central nervous system (HP:0002529)1.97812033
84Polycythemia (HP:0001901)1.93869742
85Thoracic kyphosis (HP:0002942)1.93355900
86Rapidly progressive (HP:0003678)1.91576633
87Hypertensive crisis (HP:0100735)1.91099847
88Spontaneous hematomas (HP:0007420)1.90972681
89Increased IgM level (HP:0003496)1.89504022
90Peripheral hypomyelination (HP:0007182)1.88682450
91Nemaline bodies (HP:0003798)1.87236995
92Joint stiffness (HP:0001387)1.87181553
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.87098004
94Gingivitis (HP:0000230)1.86094743
95Hyperlipoproteinemia (HP:0010980)1.85133747
96Muscle fiber inclusion bodies (HP:0100299)1.83664215
97Hematochezia (HP:0002573)1.83578898
98Akinesia (HP:0002304)1.81854860
99Arterial thrombosis (HP:0004420)1.81764068
100Supranuclear gaze palsy (HP:0000605)1.81366568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.50926624
2MAP4K13.67245578
3BLK3.19210380
4MAP3K112.93224013
5RIPK42.69527203
6IRAK42.62196427
7BCKDK2.43961781
8MAP2K32.28595183
9PRPF4B2.25270354
10TNK22.13148317
11TESK21.93604197
12KIT1.90203662
13FES1.85471424
14TYK21.83925262
15TBK11.81802478
16CSF1R1.80907635
17TAOK11.78061747
18SYK1.77493648
19TRIB31.71196649
20KDR1.70773555
21ZAP701.67941569
22TESK11.65267520
23JAK31.63998530
24ARAF1.61567672
25IKBKE1.59936911
26MAP3K131.54537355
27NME21.47235339
28BTK1.46628188
29MUSK1.37258225
30LYN1.29402604
31TAOK21.27292908
32PIM21.24343507
33SIK21.17391237
34DYRK1B1.16686936
35GRK61.11636849
36CSK1.10023750
37MAPK121.05019346
38MARK21.02713739
39MAP3K11.00565863
40IKBKB0.96545701
41MAP3K140.95953758
42HCK0.91898568
43MAPK110.91137121
44LCK0.90837701
45MOS0.88769317
46CAMKK20.85978123
47ITK0.85063647
48MATK0.84791250
49EEF2K0.83960521
50MAP3K30.82676144
51SIK10.81810446
52SMG10.76699748
53BMX0.74223682
54PDK10.73576143
55PDPK10.73413674
56CDC42BPA0.72775029
57CAMKK10.71928635
58PRKD20.68730747
59PRKD30.68696109
60PRKCQ0.67164655
61MAPK70.65791522
62MAP2K60.64787445
63FGR0.62484905
64FLT30.62143049
65JAK20.61863831
66TEC0.60300407
67JAK10.58958276
68KSR20.58842179
69IRAK20.58543145
70RAF10.58448899
71MARK30.57021124
72LRRK20.55521009
73SIK30.51792172
74DAPK20.50916107
75TTN0.50068134
76MAP2K10.49573709
77CDK120.49537895
78LIMK10.49502963
79VRK20.47996780
80MAP3K50.47254779
81MAP3K80.45828131
82MAP2K20.44832056
83TGFBR20.44157826
84HIPK20.43397550
85FYN0.43372683
86BMPR20.40471387
87CDK190.39862861
88PIK3CG0.38431666
89PRKD10.37949197
90MAPKAPK20.36240083
91MAP3K70.35881889
92MAPK30.34571467
93RPS6KC10.33898204
94RPS6KL10.33898204
95OBSCN0.33629267
96STK110.32571490
97MAPK40.32241443
98PRKG20.32108199
99PIM10.28395919
100DAPK30.27884110

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.78488121
2Asthma_Homo sapiens_hsa053103.55121580
3Autoimmune thyroid disease_Homo sapiens_hsa053203.52881522
4Other glycan degradation_Homo sapiens_hsa005113.43515512
5Graft-versus-host disease_Homo sapiens_hsa053323.36279625
6Staphylococcus aureus infection_Homo sapiens_hsa051503.29196727
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.12508896
8Leishmaniasis_Homo sapiens_hsa051402.99660301
9Type I diabetes mellitus_Homo sapiens_hsa049402.98677970
10B cell receptor signaling pathway_Homo sapiens_hsa046622.56483367
11Primary immunodeficiency_Homo sapiens_hsa053402.55838482
12Viral myocarditis_Homo sapiens_hsa054162.47178337
13Antigen processing and presentation_Homo sapiens_hsa046122.23203706
14Osteoclast differentiation_Homo sapiens_hsa043802.13322471
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.06192830
16Tuberculosis_Homo sapiens_hsa051522.01683716
17Hematopoietic cell lineage_Homo sapiens_hsa046401.86902185
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.85500373
19Lysosome_Homo sapiens_hsa041421.70954811
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65085417
21Rheumatoid arthritis_Homo sapiens_hsa053231.58130931
22Herpes simplex infection_Homo sapiens_hsa051681.49580157
23Influenza A_Homo sapiens_hsa051641.46143498
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.45599026
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45287836
26Acute myeloid leukemia_Homo sapiens_hsa052211.42589286
27Phagosome_Homo sapiens_hsa041451.42494416
28Toxoplasmosis_Homo sapiens_hsa051451.42126178
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11983901
30Pertussis_Homo sapiens_hsa051331.11264129
31Pentose phosphate pathway_Homo sapiens_hsa000300.93852118
32Malaria_Homo sapiens_hsa051440.90484809
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.89298235
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88757092
35T cell receptor signaling pathway_Homo sapiens_hsa046600.87388201
36Platelet activation_Homo sapiens_hsa046110.84588257
37Measles_Homo sapiens_hsa051620.84479115
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83572008
39Adipocytokine signaling pathway_Homo sapiens_hsa049200.83364595
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83093511
41Fructose and mannose metabolism_Homo sapiens_hsa000510.79543395
42Systemic lupus erythematosus_Homo sapiens_hsa053220.77518886
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74270639
44Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73467553
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.72606082
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68025519
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.67057891
48Salmonella infection_Homo sapiens_hsa051320.66435195
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65798462
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64835585
51TNF signaling pathway_Homo sapiens_hsa046680.63970978
52Chemokine signaling pathway_Homo sapiens_hsa040620.63283665
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61142740
54Epstein-Barr virus infection_Homo sapiens_hsa051690.60164759
55Galactose metabolism_Homo sapiens_hsa000520.59802699
56Hepatitis B_Homo sapiens_hsa051610.58499002
57Complement and coagulation cascades_Homo sapiens_hsa046100.57905348
58Peroxisome_Homo sapiens_hsa041460.55777632
59HTLV-I infection_Homo sapiens_hsa051660.54276124
60Endocytosis_Homo sapiens_hsa041440.51679928
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51452826
62Arginine biosynthesis_Homo sapiens_hsa002200.50225844
63Hepatitis C_Homo sapiens_hsa051600.50121603
64Apoptosis_Homo sapiens_hsa042100.50021768
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.49638861
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49532405
67Shigellosis_Homo sapiens_hsa051310.49396699
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48834174
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48354890
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.48232703
71VEGF signaling pathway_Homo sapiens_hsa043700.47774660
72Non-small cell lung cancer_Homo sapiens_hsa052230.45729539
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45661680
74PPAR signaling pathway_Homo sapiens_hsa033200.43764575
75Notch signaling pathway_Homo sapiens_hsa043300.41602052
76Legionellosis_Homo sapiens_hsa051340.41367940
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37180212
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.37105382
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36400102
80Arachidonic acid metabolism_Homo sapiens_hsa005900.34145180
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34000486
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32934138
83Carbon metabolism_Homo sapiens_hsa012000.30950256
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30069219
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.29752947
86Insulin resistance_Homo sapiens_hsa049310.29538295
87Fatty acid degradation_Homo sapiens_hsa000710.28785377
88Fatty acid elongation_Homo sapiens_hsa000620.28665026
89Sulfur relay system_Homo sapiens_hsa041220.27452793
90Fatty acid metabolism_Homo sapiens_hsa012120.26579196
91Chronic myeloid leukemia_Homo sapiens_hsa052200.23781944
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.22798756
93Prolactin signaling pathway_Homo sapiens_hsa049170.19595424
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17736226
95Viral carcinogenesis_Homo sapiens_hsa052030.17655798
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.16190881
97MAPK signaling pathway_Homo sapiens_hsa040100.15901785
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.15346183
99Collecting duct acid secretion_Homo sapiens_hsa049660.15315830
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.14033432

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