ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.39078332
2	DNA deamination (GO:0045006)	4.05287683
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.80121137
4	response to pheromone (GO:0019236)	3.68381459
5	replication fork processing (GO:0031297)	3.62309372
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.60864977
7	DNA double-strand break processing (GO:0000729)	3.50108059
8	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49098271
9	NADH dehydrogenase complex assembly (GO:0010257)	3.49098271
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49098271
11	protein neddylation (GO:0045116)	3.49092303
12	protein complex biogenesis (GO:0070271)	3.45537159
13	respiratory chain complex IV assembly (GO:0008535)	3.41987614
14	neural tube formation (GO:0001841)	3.38426549
15	fucose catabolic process (GO:0019317)	3.38263789
16	L-fucose metabolic process (GO:0042354)	3.38263789
17	L-fucose catabolic process (GO:0042355)	3.38263789
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.36915936
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.35862198
20	centriole replication (GO:0007099)	3.33800954
21	mitochondrial respiratory chain complex assembly (GO:0033108)	3.32996832
22	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.26676052
23	neuron fate determination (GO:0048664)	3.24501824
24	platelet dense granule organization (GO:0060155)	3.22466076
25	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.18884156
26	regulation of mitotic spindle checkpoint (GO:1903504)	3.18884156
27	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.17344619
28	kynurenine metabolic process (GO:0070189)	3.06913830
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.04440742
30	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.99824999
31	reciprocal meiotic recombination (GO:0007131)	2.99633946
32	reciprocal DNA recombination (GO:0035825)	2.99633946
33	nonmotile primary cilium assembly (GO:0035058)	2.99520637
34	ATP synthesis coupled proton transport (GO:0015986)	2.94164947
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.94164947
36	cytochrome complex assembly (GO:0017004)	2.88102491
37	chromatin remodeling at centromere (GO:0031055)	2.85508098
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.84937275
39	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.84650891
40	cornea development in camera-type eye (GO:0061303)	2.83088429
41	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.83022842
42	regulation of cilium movement (GO:0003352)	2.82720655
43	recombinational repair (GO:0000725)	2.82365660
44	pseudouridine synthesis (GO:0001522)	2.80734152
45	protein K6-linked ubiquitination (GO:0085020)	2.80454004
46	double-strand break repair via homologous recombination (GO:0000724)	2.80000865
47	protein K11-linked deubiquitination (GO:0035871)	2.76185916
48	presynaptic membrane assembly (GO:0097105)	2.75745584
49	protein-cofactor linkage (GO:0018065)	2.75553555
50	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.73149876
51	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.72460081
52	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.72460081
53	limb bud formation (GO:0060174)	2.71907667
54	tryptophan catabolic process (GO:0006569)	2.71782250
55	indole-containing compound catabolic process (GO:0042436)	2.71782250
56	indolalkylamine catabolic process (GO:0046218)	2.71782250
57	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.68695109
58	kinetochore assembly (GO:0051382)	2.67794386
59	regulation of translation, ncRNA-mediated (GO:0045974)	2.66197627
60	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.66197627
61	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.66197627
62	cilium morphogenesis (GO:0060271)	2.64488955
63	pyrimidine nucleobase catabolic process (GO:0006208)	2.62405518
64	tachykinin receptor signaling pathway (GO:0007217)	2.61411246
65	CENP-A containing nucleosome assembly (GO:0034080)	2.61070570
66	prenylation (GO:0097354)	2.60969819
67	protein prenylation (GO:0018342)	2.60969819
68	negative regulation of telomere maintenance (GO:0032205)	2.60908539
69	chaperone-mediated protein transport (GO:0072321)	2.60862981
70	resolution of meiotic recombination intermediates (GO:0000712)	2.60527582
71	organelle disassembly (GO:1903008)	2.60472565
72	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59160302
73	synapsis (GO:0007129)	2.58613276
74	indolalkylamine metabolic process (GO:0006586)	2.58431197
75	termination of RNA polymerase III transcription (GO:0006386)	2.57176789
76	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.57176789
77	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.54306049
78	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.54306049
79	somite development (GO:0061053)	2.53879339
80	microtubule depolymerization (GO:0007019)	2.53241467
81	detection of light stimulus involved in sensory perception (GO:0050962)	2.53131455
82	detection of light stimulus involved in visual perception (GO:0050908)	2.53131455
83	kinetochore organization (GO:0051383)	2.52469541
84	presynaptic membrane organization (GO:0097090)	2.52292401
85	signal peptide processing (GO:0006465)	2.51733772
86	epithelial cilium movement (GO:0003351)	2.51312045
87	electron transport chain (GO:0022900)	2.50348380
88	piRNA metabolic process (GO:0034587)	2.49775992
89	mannosylation (GO:0097502)	2.48422078
90	intracellular protein transmembrane import (GO:0044743)	2.48309484
91	respiratory electron transport chain (GO:0022904)	2.48217483
92	adaptation of signaling pathway (GO:0023058)	2.46149694
93	proteasome assembly (GO:0043248)	2.45771773
94	tryptophan metabolic process (GO:0006568)	2.44250330
95	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.43809787
96	histone exchange (GO:0043486)	2.41487067
97	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.41255027
98	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.41255027
99	isotype switching (GO:0045190)	2.41255027
100	regulation of hexokinase activity (GO:1903299)	2.41213839

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.29751046
2	VDR_22108803_ChIP-Seq_LS180_Human	3.07171170
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.76899544
4	EWS_26573619_Chip-Seq_HEK293_Human	2.63745036
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.58045065
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54257798
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.52507174
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.48867252
9	FUS_26573619_Chip-Seq_HEK293_Human	2.48698836
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.47709327
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.47386591
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46771689
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.42736635
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.40636763
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.30060126
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.29760264
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.25280788
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.18979590
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15965066
20	P300_19829295_ChIP-Seq_ESCs_Human	2.15327434
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.12416312
22	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.09992676
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.05566389
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.98919073
25	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95652000
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91433804
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.84181019
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.78681109
29	MYC_18940864_ChIP-ChIP_HL60_Human	1.72061822
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70643532
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67647314
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.63470696
33	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58627445
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.57857739
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.53753909
36	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53306431
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51714149
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49705609
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.46596319
40	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.46596319
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46464194
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43162536
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.42488796
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.38893495
45	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.38893495
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.38333498
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37674319
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37091143
49	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35358156
50	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35004675
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.34392282
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33592381
53	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.31073826
54	AR_25329375_ChIP-Seq_VCAP_Human	1.30889579
55	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.30621642
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.30407548
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30344267
58	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28801151
59	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28745668
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27730863
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26784808
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26784808
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.26390298
64	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.26092686
65	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.26057105
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.25812835
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25599663
68	* STAT3_23295773_ChIP-Seq_U87_Human	1.25403288
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25181613
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22948164
71	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.21510164
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20342060
73	TCF4_23295773_ChIP-Seq_U87_Human	1.17992546
74	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16427326
75	* TCF4_22108803_ChIP-Seq_LS180_Human	1.16251868
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15853336
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.15101305
78	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15077871
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14285305
80	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13406992
81	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.13304973
82	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12329490
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09525030
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08479831
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08019323
86	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07206110
87	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06120630
88	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05639811
89	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04337156
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.04176369
91	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.01200779
92	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00783718
93	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00783718
94	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00095059
95	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.99795042
96	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.98956387
97	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.98227329
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97978329
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.97696507
100	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.95568653

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.41666015
2	MP0006292_abnormal_olfactory_placode	2.98231657
3	MP0002102_abnormal_ear_morphology	2.89121110
4	MP0000569_abnormal_digit_pigmentation	2.67431280
5	MP0006072_abnormal_retinal_apoptosis	2.40520259
6	MP0003136_yellow_coat_color	2.27723351
7	MP0002736_abnormal_nociception_after	2.24803726
8	MP0003787_abnormal_imprinting	2.24541512
9	MP0002938_white_spotting	2.16967201
10	MP0003880_abnormal_central_pattern	2.15131510
11	MP0002638_abnormal_pupillary_reflex	2.14839179
12	MP0001968_abnormal_touch/_nociception	2.13351708
13	MP0003195_calcinosis	2.13230579
14	MP0008058_abnormal_DNA_repair	2.09614076
15	MP0002837_dystrophic_cardiac_calcinosis	2.06799430
16	MP0000372_irregular_coat_pigmentation	1.99590764
17	MP0001529_abnormal_vocalization	1.87015560
18	MP0002653_abnormal_ependyma_morphology	1.85613148
19	MP0005253_abnormal_eye_physiology	1.82168207
20	MP0005551_abnormal_eye_electrophysiolog	1.81862585
21	MP0004142_abnormal_muscle_tone	1.79911030
22	MP0008057_abnormal_DNA_replication	1.76992247
23	MP0003646_muscle_fatigue	1.73784106
24	MP0008789_abnormal_olfactory_epithelium	1.68280243
25	MP0010094_abnormal_chromosome_stability	1.66264835
26	MP0001986_abnormal_taste_sensitivity	1.62331743
27	MP0003718_maternal_effect	1.59202832
28	MP0002735_abnormal_chemical_nociception	1.58821410
29	MP0000631_abnormal_neuroendocrine_gland	1.57783700
30	MP0009046_muscle_twitch	1.52564678
31	MP0006276_abnormal_autonomic_nervous	1.50115393
32	MP0008872_abnormal_physiological_respon	1.49909937
33	MP0001293_anophthalmia	1.48764388
34	MP0009745_abnormal_behavioral_response	1.48090145
35	MP0004147_increased_porphyrin_level	1.44664675
36	MP0004133_heterotaxia	1.44483091
37	MP0001984_abnormal_olfaction	1.42823906
38	MP0003121_genomic_imprinting	1.39450694
39	MP0009697_abnormal_copulation	1.38430158
40	MP0000778_abnormal_nervous_system	1.36939123
41	MP0001485_abnormal_pinna_reflex	1.35991969
42	MP0005645_abnormal_hypothalamus_physiol	1.34777851
43	MP0003890_abnormal_embryonic-extraembry	1.33532787
44	MP0002234_abnormal_pharynx_morphology	1.32129059
45	MP0004145_abnormal_muscle_electrophysio	1.27532639
46	MP0005084_abnormal_gallbladder_morpholo	1.27165094
47	MP0001486_abnormal_startle_reflex	1.25931052
48	MP0002272_abnormal_nervous_system	1.23804953
49	MP0002751_abnormal_autonomic_nervous	1.20361730
50	MP0004924_abnormal_behavior	1.20042430
51	MP0005386_behavior/neurological_phenoty	1.20042430
52	MP0005394_taste/olfaction_phenotype	1.19768438
53	MP0005499_abnormal_olfactory_system	1.19768438
54	MP0005174_abnormal_tail_pigmentation	1.16092489
55	MP0003937_abnormal_limbs/digits/tail_de	1.14279446
56	MP0004215_abnormal_myocardial_fiber	1.14199925
57	MP0000427_abnormal_hair_cycle	1.14102116
58	MP0004742_abnormal_vestibular_system	1.12655661
59	MP0003693_abnormal_embryo_hatching	1.12650767
60	MP0002163_abnormal_gland_morphology	1.12061512
61	MP0005646_abnormal_pituitary_gland	1.11250677
62	MP0004885_abnormal_endolymph	1.10184552
63	MP0003567_abnormal_fetal_cardiomyocyte	1.06526954
64	MP0005187_abnormal_penis_morphology	1.04174297
65	MP0003119_abnormal_digestive_system	1.04158239
66	MP0002067_abnormal_sensory_capabilities	1.03645473
67	MP0005195_abnormal_posterior_eye	1.02714318
68	MP0008995_early_reproductive_senescence	1.01853488
69	MP0002557_abnormal_social/conspecific_i	1.00914328
70	MP0005389_reproductive_system_phenotype	1.00758241
71	MP0002095_abnormal_skin_pigmentation	1.00480124
72	MP0005391_vision/eye_phenotype	1.00289101
73	MP0002572_abnormal_emotion/affect_behav	0.99311917
74	MP0001919_abnormal_reproductive_system	0.98770104
75	MP0002210_abnormal_sex_determination	0.93887161
76	MP0000049_abnormal_middle_ear	0.93136919
77	MP0001286_abnormal_eye_development	0.91511474
78	MP0002752_abnormal_somatic_nervous	0.91462780
79	MP0001324_abnormal_eye_pigmentation	0.91225850
80	MP0002928_abnormal_bile_duct	0.90675614
81	MP0002277_abnormal_respiratory_mucosa	0.90281917
82	MP0002734_abnormal_mechanical_nocicepti	0.89048625
83	MP0001929_abnormal_gametogenesis	0.89009844
84	MP0003122_maternal_imprinting	0.87154295
85	MP0003137_abnormal_impulse_conducting	0.86734472
86	MP0005423_abnormal_somatic_nervous	0.85410841
87	MP0002160_abnormal_reproductive_system	0.84671789
88	MP0001970_abnormal_pain_threshold	0.83897825
89	MP0008007_abnormal_cellular_replicative	0.83622286
90	MP0002733_abnormal_thermal_nociception	0.82656447
91	MP0000026_abnormal_inner_ear	0.81195389
92	MP0003698_abnormal_male_reproductive	0.80092669
93	MP0002064_seizures	0.79287888
94	MP0002233_abnormal_nose_morphology	0.78739792
95	MP0002063_abnormal_learning/memory/cond	0.78604162
96	MP0002282_abnormal_trachea_morphology	0.78349243
97	MP0000647_abnormal_sebaceous_gland	0.77798050
98	MP0004043_abnormal_pH_regulation	0.77294959
99	MP0000653_abnormal_sex_gland	0.76976770
100	MP0002184_abnormal_innervation	0.76659117

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.00010523
2	Pancreatic fibrosis (HP:0100732)	3.79299290
3	True hermaphroditism (HP:0010459)	3.78091880
4	Abnormality of midbrain morphology (HP:0002418)	3.72772459
5	Molar tooth sign on MRI (HP:0002419)	3.72772459
6	Nephronophthisis (HP:0000090)	3.12099751
7	Acute necrotizing encephalopathy (HP:0006965)	3.01538145
8	Hyperventilation (HP:0002883)	2.88722741
9	Medial flaring of the eyebrow (HP:0010747)	2.81917341
10	Mitochondrial inheritance (HP:0001427)	2.73684787
11	Abnormality of the renal cortex (HP:0011035)	2.73196429
12	Congenital stationary night blindness (HP:0007642)	2.73081114
13	Abnormality of the labia minora (HP:0012880)	2.72592643
14	Progressive macrocephaly (HP:0004481)	2.72520430
15	Increased CSF lactate (HP:0002490)	2.69750309
16	Abnormality of the renal medulla (HP:0100957)	2.65362096
17	Acute encephalopathy (HP:0006846)	2.57432872
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.53554291
19	Colon cancer (HP:0003003)	2.53195152
20	Type II lissencephaly (HP:0007260)	2.45386596
21	Abnormality of the pons (HP:0007361)	2.43879080
22	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.43718804
23	Increased hepatocellular lipid droplets (HP:0006565)	2.37693881
24	Hypoplasia of the pons (HP:0012110)	2.37521875
25	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.36102451
26	Birth length less than 3rd percentile (HP:0003561)	2.35475190
27	Renal cortical cysts (HP:0000803)	2.35260062
28	Methylmalonic acidemia (HP:0002912)	2.34081258
29	Lipid accumulation in hepatocytes (HP:0006561)	2.32807763
30	Gait imbalance (HP:0002141)	2.31812316
31	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.29685544
32	Abnormality of alanine metabolism (HP:0010916)	2.29685544
33	Hyperalaninemia (HP:0003348)	2.29685544
34	Chronic hepatic failure (HP:0100626)	2.29173976
35	Meckel diverticulum (HP:0002245)	2.27427689
36	Abnormality of the ileum (HP:0001549)	2.26994745
37	Congenital primary aphakia (HP:0007707)	2.25888223
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25759442
39	Sclerocornea (HP:0000647)	2.25335157
40	Inability to walk (HP:0002540)	2.24633989
41	Cystic liver disease (HP:0006706)	2.24606532
42	Anencephaly (HP:0002323)	2.20034256
43	Pendular nystagmus (HP:0012043)	2.17960998
44	Hepatocellular necrosis (HP:0001404)	2.16671716
45	Lissencephaly (HP:0001339)	2.14086749
46	Intestinal atresia (HP:0011100)	2.13852517
47	Optic nerve hypoplasia (HP:0000609)	2.13559558
48	Abnormality of chromosome stability (HP:0003220)	2.13544001
49	Hepatic necrosis (HP:0002605)	2.09249946
50	Short tibia (HP:0005736)	2.09063828
51	Nephrogenic diabetes insipidus (HP:0009806)	2.08501111
52	Broad-based gait (HP:0002136)	2.04927097
53	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04892501
54	Abolished electroretinogram (ERG) (HP:0000550)	2.04429086
55	3-Methylglutaconic aciduria (HP:0003535)	2.03701831
56	Volvulus (HP:0002580)	2.01607257
57	Genital tract atresia (HP:0001827)	2.01182260
58	Tubular atrophy (HP:0000092)	2.00316030
59	Male pseudohermaphroditism (HP:0000037)	1.96736439
60	Methylmalonic aciduria (HP:0012120)	1.96017041
61	Bile duct proliferation (HP:0001408)	1.95349542
62	Abnormal biliary tract physiology (HP:0012439)	1.95349542
63	Postaxial foot polydactyly (HP:0001830)	1.95278563
64	Vaginal atresia (HP:0000148)	1.93009596
65	Optic disc pallor (HP:0000543)	1.91423011
66	Attenuation of retinal blood vessels (HP:0007843)	1.91303339
67	Chromsome breakage (HP:0040012)	1.89184282
68	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.88132417
69	Progressive inability to walk (HP:0002505)	1.87463117
70	Congenital, generalized hypertrichosis (HP:0004540)	1.87295408
71	Furrowed tongue (HP:0000221)	1.87218494
72	Supernumerary spleens (HP:0009799)	1.86043201
73	Sloping forehead (HP:0000340)	1.85701554
74	Septo-optic dysplasia (HP:0100842)	1.84893023
75	Patellar aplasia (HP:0006443)	1.84887432
76	Dandy-Walker malformation (HP:0001305)	1.84550205
77	Preaxial hand polydactyly (HP:0001177)	1.83897776
78	Cerebellar dysplasia (HP:0007033)	1.82042410
79	Cerebral edema (HP:0002181)	1.80522995
80	Increased serum lactate (HP:0002151)	1.79545082
81	Hypothermia (HP:0002045)	1.79226270
82	Congenital hepatic fibrosis (HP:0002612)	1.77875205
83	Protruding tongue (HP:0010808)	1.77375044
84	Decreased central vision (HP:0007663)	1.77312782
85	Hypoplasia of the fovea (HP:0007750)	1.75971794
86	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.75971794
87	Drooling (HP:0002307)	1.75673978
88	Stomach cancer (HP:0012126)	1.75432242
89	Triphalangeal thumb (HP:0001199)	1.75306665
90	Postaxial hand polydactyly (HP:0001162)	1.74081000
91	Polydipsia (HP:0001959)	1.73926192
92	Abnormal drinking behavior (HP:0030082)	1.73926192
93	Aplasia/Hypoplasia of the patella (HP:0006498)	1.72398188
94	Oligodactyly (hands) (HP:0001180)	1.72395919
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.71897080
96	Renal Fanconi syndrome (HP:0001994)	1.70241688
97	Fair hair (HP:0002286)	1.68735662
98	Gaze-evoked nystagmus (HP:0000640)	1.68214694
99	Pachygyria (HP:0001302)	1.67589060
100	Poor coordination (HP:0002370)	1.67532511

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.65658526
2	WNK3	2.74266228
3	ZAK	2.67115010
4	BMPR1B	2.46481097
5	CASK	2.45005059
6	NUAK1	2.44243529
7	TNIK	2.38417266
8	MAP4K2	2.32717803
9	WEE1	2.18925965
10	PNCK	2.17403371
11	MKNK2	2.12655205
12	TRIM28	2.06957872
13	ADRBK2	2.06925395
14	ACVR1B	2.06046951
15	MST4	1.98252373
16	PLK4	1.79946985
17	VRK1	1.77876826
18	BRSK2	1.74927643
19	MAPK13	1.67981654
20	MKNK1	1.57991538
21	TSSK6	1.56148459
22	PLK3	1.55678599
23	MAP3K4	1.50728173
24	GRK1	1.44566305
25	EIF2AK3	1.41267438
26	DYRK2	1.39694121
27	INSRR	1.39184188
28	WNK4	1.38134757
29	BCR	1.36910924
30	VRK2	1.34165928
31	MARK1	1.33803684
32	BUB1	1.33583977
33	TXK	1.32214525
34	PLK2	1.27213802
35	PINK1	1.22124972
36	DYRK3	1.21333249
37	SRPK1	1.19218360
38	TAOK3	1.16508185
39	STK39	1.16008180
40	TLK1	1.14227971
41	OXSR1	1.11270999
42	CDC7	1.06110026
43	STK16	1.01378687
44	CSNK1G2	1.01163432
45	CSNK1G1	0.98712393
46	STK38L	0.97991382
47	NME1	0.95795027
48	TAF1	0.95793912
49	IRAK1	0.94736893
50	STK3	0.92726273
51	ERBB3	0.90505240
52	PAK3	0.89191566
53	CSNK1G3	0.87817001
54	PRKCG	0.85656567
55	OBSCN	0.82751087
56	MAP2K7	0.82111391
57	PLK1	0.75662230
58	DAPK2	0.75277987
59	CSNK1A1L	0.72002003
60	PRKCE	0.71573737
61	NEK1	0.69881153
62	TGFBR1	0.68994599
63	NEK2	0.66846037
64	ADRBK1	0.66088252
65	MAPKAPK5	0.64884257
66	ATR	0.64460956
67	MAPK15	0.64349318
68	CAMKK2	0.64011185
69	NLK	0.61991395
70	PDK2	0.61529890
71	EIF2AK2	0.60599375
72	TTK	0.56112614
73	CCNB1	0.55252913
74	BCKDK	0.53405059
75	CHEK2	0.51264455
76	PTK2B	0.50777410
77	CDK3	0.50595668
78	AKT3	0.48831941
79	EPHA4	0.48797147
80	CDK8	0.47178142
81	NTRK2	0.46097907
82	RPS6KA5	0.45532163
83	ATM	0.45283209
84	CAMK2A	0.43918259
85	PRKCQ	0.42288541
86	PHKG2	0.41490518
87	PHKG1	0.41490518
88	PKN1	0.40937103
89	MAP3K12	0.39750912
90	EPHA3	0.39682440
91	PIK3CA	0.38870780
92	TEC	0.37848199
93	EIF2AK1	0.37570309
94	MUSK	0.36579908
95	DYRK1A	0.36165002
96	GRK7	0.36158518
97	CSNK1A1	0.35702626
98	RPS6KA4	0.33479720
99	CSNK1D	0.32500384
100	PRKACA	0.31508855

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.15750826
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15413369
3	Homologous recombination_Homo sapiens_hsa03440	2.86789188
4	Parkinsons disease_Homo sapiens_hsa05012	2.74856676
5	RNA polymerase_Homo sapiens_hsa03020	2.56079506
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.39949544
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.31465795
8	Proteasome_Homo sapiens_hsa03050	2.31280668
9	Basal transcription factors_Homo sapiens_hsa03022	2.25547050
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.23049295
11	RNA degradation_Homo sapiens_hsa03018	2.20691715
12	Phototransduction_Homo sapiens_hsa04744	2.20359625
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02760017
14	Huntingtons disease_Homo sapiens_hsa05016	1.88645166
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.85226038
16	Non-homologous end-joining_Homo sapiens_hsa03450	1.85018292
17	Mismatch repair_Homo sapiens_hsa03430	1.84198924
18	Nicotine addiction_Homo sapiens_hsa05033	1.78650767
19	Butanoate metabolism_Homo sapiens_hsa00650	1.75078812
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.75049918
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.70477926
22	Ribosome_Homo sapiens_hsa03010	1.69434610
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61738512
24	Alzheimers disease_Homo sapiens_hsa05010	1.59001838
25	Propanoate metabolism_Homo sapiens_hsa00640	1.58964624
26	One carbon pool by folate_Homo sapiens_hsa00670	1.56196362
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.53807399
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.51243760
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49532564
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42511298
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.41398908
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.39333137
33	Nucleotide excision repair_Homo sapiens_hsa03420	1.33098454
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31136678
35	RNA transport_Homo sapiens_hsa03013	1.28319227
36	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.27480410
37	Spliceosome_Homo sapiens_hsa03040	1.25828013
38	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.23412695
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23132457
40	Steroid biosynthesis_Homo sapiens_hsa00100	1.20215984
41	Caffeine metabolism_Homo sapiens_hsa00232	1.14904355
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.07552553
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.06713390
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04557822
45	Purine metabolism_Homo sapiens_hsa00230	1.02847457
46	DNA replication_Homo sapiens_hsa03030	1.02412060
47	Primary immunodeficiency_Homo sapiens_hsa05340	0.92310690
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.90110944
49	Regulation of autophagy_Homo sapiens_hsa04140	0.89944514
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.87620345
51	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87144366
52	Olfactory transduction_Homo sapiens_hsa04740	0.85951972
53	Cell cycle_Homo sapiens_hsa04110	0.83161584
54	Morphine addiction_Homo sapiens_hsa05032	0.82757122
55	Taste transduction_Homo sapiens_hsa04742	0.79909387
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79104309
57	Peroxisome_Homo sapiens_hsa04146	0.78264503
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.76927863
59	GABAergic synapse_Homo sapiens_hsa04727	0.76078156
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73543717
61	Base excision repair_Homo sapiens_hsa03410	0.70594289
62	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68484706
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67098205
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.67011338
65	p53 signaling pathway_Homo sapiens_hsa04115	0.66714414
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66600654
67	Serotonergic synapse_Homo sapiens_hsa04726	0.66473074
68	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64670114
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63255444
70	Chemical carcinogenesis_Homo sapiens_hsa05204	0.62743864
71	Basal cell carcinoma_Homo sapiens_hsa05217	0.61290016
72	Metabolic pathways_Homo sapiens_hsa01100	0.60254262
73	Fatty acid elongation_Homo sapiens_hsa00062	0.56828627
74	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55929625
75	Retinol metabolism_Homo sapiens_hsa00830	0.55108482
76	Circadian entrainment_Homo sapiens_hsa04713	0.52964898
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.52410952
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51752386
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.49858446
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.47649806
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.44016522
82	Folate biosynthesis_Homo sapiens_hsa00790	0.42743359
83	Circadian rhythm_Homo sapiens_hsa04710	0.41751263
84	Oocyte meiosis_Homo sapiens_hsa04114	0.41529829
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40852947
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39955796
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37267035
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37198308
89	ABC transporters_Homo sapiens_hsa02010	0.37147210
90	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37013010
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35330160
92	Insulin secretion_Homo sapiens_hsa04911	0.34635504
93	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32990313
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.31998925
95	mRNA surveillance pathway_Homo sapiens_hsa03015	0.29999410
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28951357
97	Asthma_Homo sapiens_hsa05310	0.28767379
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.27452532
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.26749747
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26673968

C16ORF87

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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