C16ORF89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcription factors and proteins, this gene may function in the development and function of the thyroid. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.34678513
2cilium or flagellum-dependent cell motility (GO:0001539)7.92197408
3cilium movement (GO:0003341)6.93648623
4thyroid gland development (GO:0030878)6.70724260
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.68247376
6motile cilium assembly (GO:0044458)6.39744864
7sulfate transmembrane transport (GO:1902358)6.09914166
8epithelial cilium movement (GO:0003351)5.99880016
9one-carbon compound transport (GO:0019755)5.51463049
10negative regulation of humoral immune response (GO:0002921)5.16228698
11axoneme assembly (GO:0035082)5.12003207
12cellular response to nitric oxide (GO:0071732)5.07646832
13sulfate transport (GO:0008272)4.96753126
14left/right pattern formation (GO:0060972)4.72120843
15primary alcohol catabolic process (GO:0034310)4.61580728
16hydrogen peroxide catabolic process (GO:0042744)4.47645931
17negative regulation of complement activation (GO:0045916)4.30667465
18ethanol metabolic process (GO:0006067)4.12556271
19negative regulation of B cell mediated immunity (GO:0002713)4.08414439
20negative regulation of immunoglobulin mediated immune response (GO:0002890)4.08414439
21cellular response to reactive nitrogen species (GO:1902170)3.94355583
22ethanol oxidation (GO:0006069)3.92997483
23negative regulation of protein activation cascade (GO:2000258)3.75485582
24pattern specification involved in kidney development (GO:0061004)3.75258626
25hormone biosynthetic process (GO:0042446)3.70429296
26membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.67989056
27calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.53000179
28vitamin transmembrane transport (GO:0035461)3.51981496
29regulation of cilium movement (GO:0003352)3.48340975
30cellular response to gonadotropin stimulus (GO:0071371)3.46019175
31response to nitric oxide (GO:0071731)3.39382920
32hydrogen peroxide metabolic process (GO:0042743)3.38190564
33lung epithelium development (GO:0060428)3.37909206
34trivalent inorganic anion homeostasis (GO:0072506)3.37716720
35phosphate ion homeostasis (GO:0055062)3.37716720
36nephron tubule formation (GO:0072079)3.37481165
37sodium ion homeostasis (GO:0055078)3.37381575
38phenol-containing compound catabolic process (GO:0019336)3.37303968
39membrane repolarization during action potential (GO:0086011)3.35867299
40positive regulation of digestive system process (GO:0060456)3.33840877
41respiratory gaseous exchange (GO:0007585)3.33649449
42regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.30422338
43phenol-containing compound metabolic process (GO:0018958)3.22427728
44mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.21747166
45peptide catabolic process (GO:0043171)3.18500685
46macrophage chemotaxis (GO:0048246)3.13424897
47intraciliary transport (GO:0042073)3.12242708
48metanephric tubule development (GO:0072170)3.11787101
49metanephric nephron tubule development (GO:0072234)3.11787101
50dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.11130489
51left/right axis specification (GO:0070986)3.06726395
52cellular anion homeostasis (GO:0030002)2.96194991
53regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.94934418
54polyol transport (GO:0015791)2.92864475
55cilium organization (GO:0044782)2.90510027
56regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.88218737
57phosphate ion transmembrane transport (GO:0035435)2.87786796
58peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.86903821
59sulfur compound transport (GO:0072348)2.86227479
60lung secretory cell differentiation (GO:0061140)2.84266833
61iron ion import (GO:0097286)2.83931549
62response to xenobiotic stimulus (GO:0009410)2.82592715
63multicellular organismal water homeostasis (GO:0050891)2.81104750
64cilium assembly (GO:0042384)2.80843190
65metanephric nephron epithelium development (GO:0072243)2.77822382
66renal absorption (GO:0070293)2.75976774
67microtubule bundle formation (GO:0001578)2.73531828
68establishment of apical/basal cell polarity (GO:0035089)2.72981414
69regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.59755220
70neurotransmitter biosynthetic process (GO:0042136)2.56890441
71excretion (GO:0007588)2.55874310
72ventricular system development (GO:0021591)2.55266489
73water homeostasis (GO:0030104)2.54227416
74negative regulation of metanephros development (GO:0072217)2.52119121
75metanephric epithelium development (GO:0072207)2.49855642
76carnitine metabolic process (GO:0009437)2.48839553
77establishment of monopolar cell polarity (GO:0061162)2.48751080
78establishment or maintenance of monopolar cell polarity (GO:0061339)2.48751080
79atrial cardiac muscle cell action potential (GO:0086014)2.47713766
80establishment of tissue polarity (GO:0007164)2.44660793
81establishment of planar polarity (GO:0001736)2.44660793
82phosphate ion transport (GO:0006817)2.43752585
83negative regulation of interleukin-2 production (GO:0032703)2.43702803
84negative regulation of T cell differentiation in thymus (GO:0033085)2.42350742
85membrane protein proteolysis (GO:0033619)2.36603779
86pyrimidine-containing compound transmembrane transport (GO:0072531)2.36461012
87membrane repolarization (GO:0086009)2.36445835
88positive regulation of hormone metabolic process (GO:0032352)2.36166506
89O-glycan processing (GO:0016266)2.35885566
90protein localization to cilium (GO:0061512)2.35048803
91regulation of complement activation (GO:0030449)2.34215536
92negative regulation of hormone biosynthetic process (GO:0032353)2.33945551
93cilium morphogenesis (GO:0060271)2.32876764
94negative regulation of transcription by competitive promoter binding (GO:0010944)2.32059950
95exogenous drug catabolic process (GO:0042738)2.31820559
96regulation of interleukin-5 production (GO:0032674)2.30879595
97surfactant homeostasis (GO:0043129)16.8019882
98thyroid hormone generation (GO:0006590)16.7137328
99thyroid hormone metabolic process (GO:0042403)13.8696856
100chemical homeostasis within a tissue (GO:0048875)13.7756836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96885972
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.77041561
3EZH2_22144423_ChIP-Seq_EOC_Human2.69578517
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42699743
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.38038525
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35058432
7DROSHA_22980978_ChIP-Seq_HELA_Human2.34863161
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.19383719
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.17878970
10AR_21572438_ChIP-Seq_LNCaP_Human2.06337859
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.05092816
12PIAS1_25552417_ChIP-Seq_VCAP_Human1.83308925
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79142620
14VDR_22108803_ChIP-Seq_LS180_Human1.76629719
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.72172374
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67423409
17* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.55397973
18AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53142942
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50328576
20AHR_22903824_ChIP-Seq_MCF-7_Human1.47089618
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46185333
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44423107
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42290022
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41746015
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.40156645
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.39750151
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.37171435
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34945130
29SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34567574
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34355881
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34132018
32SMAD3_21741376_ChIP-Seq_HESCs_Human1.33689468
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32844406
34BCAT_22108803_ChIP-Seq_LS180_Human1.32105986
35SOX2_20726797_ChIP-Seq_SW620_Human1.31759680
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.31575085
37NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29262153
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28632938
39FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28269949
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26804234
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.25190968
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25019226
43SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23774361
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20691871
45TAF15_26573619_Chip-Seq_HEK293_Human1.20665416
46SMAD4_21799915_ChIP-Seq_A2780_Human1.20316402
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.20028367
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.18741514
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.16146848
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15569239
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14070585
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.13467456
53GATA4_25053715_ChIP-Seq_YYC3_Human1.13266389
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11687263
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09634546
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.09377132
57* RUNX2_22187159_ChIP-Seq_PCA_Human1.07948920
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.07937817
59SMAD4_21741376_ChIP-Seq_HESCs_Human1.07511545
60ETV1_20927104_ChIP-Seq_GIST48_Human1.07404441
61PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06252143
62STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06028066
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05413272
64GBX2_23144817_ChIP-Seq_PC3_Human1.03934250
65* FOXA1_25552417_ChIP-Seq_VCAP_Human1.03905550
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03544341
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02651246
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01857750
69CJUN_26792858_Chip-Seq_BT549_Human1.00164848
70WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99789926
71TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98089729
72CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95203230
73KLF5_25053715_ChIP-Seq_YYC3_Human0.94691027
74EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94262807
75RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94262807
76LXR_22158963_ChIP-Seq_LIVER_Mouse0.94164209
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93519367
78RNF2_27304074_Chip-Seq_NSC_Mouse0.93231549
79TP63_23658742_ChIP-Seq_EP156T_Human0.93161637
80TCF4_22108803_ChIP-Seq_LS180_Human0.92967515
81JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91978814
82SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90730112
83TP53_18474530_ChIP-ChIP_U2OS_Human0.90236093
84TCF4_18268006_ChIP-ChIP_LS174T_Human0.89765145
85TBX20_22328084_ChIP-Seq_HEART_Mouse0.88901874
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.88901874
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.88592309
88TP53_16413492_ChIP-PET_HCT116_Human0.88428647
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87861844
90PHF8_20622853_ChIP-Seq_HELA_Human0.86730602
91* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86714520
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86661504
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85807010
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85676047
95MYC_27129775_Chip-Seq_CORNEA_Mouse0.84792625
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.84775969
97FOXO3_23340844_ChIP-Seq_DLD1_Human0.84564959
98RBPJ_21746931_ChIP-Seq_IB4_Human0.83811844
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.83499203
100NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83328786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000681_abnormal_thyroid_gland6.24977684
2MP0004782_abnormal_surfactant_physiolog6.21162067
3MP0001958_emphysema5.21138427
4MP0008004_abnormal_stomach_pH5.11674647
5MP0002876_abnormal_thyroid_physiology4.82760736
6MP0008995_early_reproductive_senescence4.37009135
7MP0004043_abnormal_pH_regulation4.04787820
8MP0008875_abnormal_xenobiotic_pharmacok3.93011283
9MP0000383_abnormal_hair_follicle3.57848349
10MP0004885_abnormal_endolymph2.85623789
11MP0005083_abnormal_biliary_tract2.81491358
12MP0010678_abnormal_skin_adnexa2.64202340
13MP0001485_abnormal_pinna_reflex2.50266827
14MP0002653_abnormal_ependyma_morphology2.47880479
15MP0001501_abnormal_sleep_pattern2.36233045
16MP0009780_abnormal_chondrocyte_physiolo2.18880952
17MP0005388_respiratory_system_phenotype2.04686540
18MP0002133_abnormal_respiratory_system2.04686540
19MP0004133_heterotaxia1.77218631
20MP0001984_abnormal_olfaction1.62411270
21MP0008789_abnormal_olfactory_epithelium1.60886471
22MP0010368_abnormal_lymphatic_system1.55159745
23MP0000566_synostosis1.52380553
24MP0005503_abnormal_tendon_morphology1.35423865
25MP0004742_abnormal_vestibular_system1.34662593
26MP0001177_atelectasis1.33070509
27MP0005365_abnormal_bile_salt1.27803379
28MP0004019_abnormal_vitamin_homeostasis1.26438267
29MP0001756_abnormal_urination1.18946246
30MP0009643_abnormal_urine_homeostasis1.18675692
31MP0001664_abnormal_digestion1.17533421
32MP0000026_abnormal_inner_ear1.17338269
33MP0002277_abnormal_respiratory_mucosa1.16589177
34MP0002295_abnormal_pulmonary_circulatio1.14845675
35MP0002132_abnormal_respiratory_system1.08806776
36MP0005394_taste/olfaction_phenotype1.06675399
37MP0005499_abnormal_olfactory_system1.06675399
38MP0001963_abnormal_hearing_physiology1.05703021
39MP0005165_increased_susceptibility_to1.05247529
40MP0001765_abnormal_ion_homeostasis1.02660593
41MP0003890_abnormal_embryonic-extraembry1.01545072
42MP0002909_abnormal_adrenal_gland1.00968516
43MP0001440_abnormal_grooming_behavior1.00208302
44MP0003879_abnormal_hair_cell0.99710765
45MP0003938_abnormal_ear_development0.98766136
46MP0001502_abnormal_circadian_rhythm0.96122023
47MP0001879_abnormal_lymphatic_vessel0.92785268
48MP0003786_premature_aging0.92529831
49MP0002168_other_aberrant_phenotype0.92047849
50MP0000631_abnormal_neuroendocrine_gland0.91934581
51MP0005085_abnormal_gallbladder_physiolo0.86864059
52MP0002229_neurodegeneration0.78587921
53MP0001851_eye_inflammation0.77849635
54MP0003638_abnormal_response/metabolism_0.76960943
55MP0005551_abnormal_eye_electrophysiolog0.74297745
56MP0003136_yellow_coat_color0.72990146
57MP0002272_abnormal_nervous_system0.70524215
58MP0003075_altered_response_to0.66372243
59MP0008569_lethality_at_weaning0.66302647
60MP0001542_abnormal_bone_strength0.66239585
61MP0002118_abnormal_lipid_homeostasis0.66216549
62MP0003953_abnormal_hormone_level0.65804296
63MP0009745_abnormal_behavioral_response0.65653094
64MP0003878_abnormal_ear_physiology0.65175841
65MP0005377_hearing/vestibular/ear_phenot0.65175841
66MP0005167_abnormal_blood-brain_barrier0.63530688
67MP0003137_abnormal_impulse_conducting0.62306887
68MP0003724_increased_susceptibility_to0.61431357
69MP0002638_abnormal_pupillary_reflex0.61383073
70MP0005584_abnormal_enzyme/coenzyme_acti0.61031053
71MP0004883_abnormal_blood_vessel0.59442362
72MP0005164_abnormal_response_to0.59069327
73MP0009046_muscle_twitch0.55266757
74MP0005636_abnormal_mineral_homeostasis0.54979658
75MP0002136_abnormal_kidney_physiology0.54504078
76MP0002557_abnormal_social/conspecific_i0.51932094
77MP0004484_altered_response_of0.51645187
78MP0009379_abnormal_foot_pigmentation0.50805762
79MP0000470_abnormal_stomach_morphology0.49972190
80MP0002572_abnormal_emotion/affect_behav0.49237875
81MP0004085_abnormal_heartbeat0.48592257
82MP0005058_abnormal_lysosome_morphology0.47721357
83MP0005253_abnormal_eye_physiology0.46719966
84MP0000465_gastrointestinal_hemorrhage0.44897574
85MP0000920_abnormal_myelination0.44804205
86MP0002405_respiratory_system_inflammati0.44386397
87MP0005332_abnormal_amino_acid0.43365925
88MP0003566_abnormal_cell_adhesion0.43338944
89MP0002064_seizures0.42798098
90MP0002735_abnormal_chemical_nociception0.42589789
91MP0002733_abnormal_thermal_nociception0.40106302
92MP0005646_abnormal_pituitary_gland0.39015676
93MP0001905_abnormal_dopamine_level0.39001206
94MP0002135_abnormal_kidney_morphology0.38243787
95MP0001968_abnormal_touch/_nociception0.37946922
96MP0001970_abnormal_pain_threshold0.37605319
97MP0001175_abnormal_lung_morphology0.37565094
98MP0000049_abnormal_middle_ear0.37105352
99MP0002734_abnormal_mechanical_nocicepti0.35453584
100MP0001943_abnormal_respiration0.34161404

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)8.73722686
2Goiter (HP:0000853)8.34225978
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.11171520
4Abnormal respiratory epithelium morphology (HP:0012253)7.41367806
5Abnormal respiratory motile cilium morphology (HP:0005938)7.41367806
6Dynein arm defect of respiratory motile cilia (HP:0012255)7.34815875
7Absent/shortened dynein arms (HP:0200106)7.34815875
8Abnormal respiratory motile cilium physiology (HP:0012261)7.19661702
9Interstitial pulmonary disease (HP:0006530)7.16672596
10Abnormal ciliary motility (HP:0012262)7.11236950
11Rhinitis (HP:0012384)6.65255301
12Chronic bronchitis (HP:0004469)6.62884445
13Bronchiectasis (HP:0002110)5.10450628
14Congenital sensorineural hearing impairment (HP:0008527)5.03653097
15Hyperactive renin-angiotensin system (HP:0000841)4.91614776
16Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)4.75914899
17Tubulointerstitial fibrosis (HP:0005576)4.41448732
18Pili torti (HP:0003777)3.94783406
19Renal salt wasting (HP:0000127)3.93416708
20Nasal polyposis (HP:0100582)3.76600775
21Decreased circulating renin level (HP:0003351)3.64657979
22Small epiphyses (HP:0010585)3.56136291
23Tachypnea (HP:0002789)3.49847885
24Hyperthyroidism (HP:0000836)3.46971857
25Abnormality of the nasal mucosa (HP:0000433)3.39208505
26Bronchitis (HP:0012387)3.36901739
27Tubulointerstitial nephritis (HP:0001970)3.17346117
28Tubulointerstitial abnormality (HP:0001969)3.17295168
29Thyroid carcinoma (HP:0002890)3.11095524
30Abnormality of cochlea (HP:0000375)3.07199779
31Respiratory distress (HP:0002098)2.98873606
32Hyperaldosteronism (HP:0000859)2.90180097
33Abnormality of renin-angiotensin system (HP:0000847)2.78098696
34Pancreatic fibrosis (HP:0100732)2.77641274
35Hyperpituitarism (HP:0010514)2.73992438
36True hermaphroditism (HP:0010459)2.69216984
37Recurrent sinusitis (HP:0011108)2.66846894
38Hypothermia (HP:0002045)2.66175513
39Chronic sinusitis (HP:0011109)2.63341099
40Infertility (HP:0000789)2.57787239
41Tubular atrophy (HP:0000092)2.54328498
42Hypothyroidism (HP:0000821)2.54026923
43Abnormality of chloride homeostasis (HP:0011422)2.48136779
44Hyperkalemia (HP:0002153)2.47029886
45Morphological abnormality of the inner ear (HP:0011390)2.42779269
46Abnormality of midbrain morphology (HP:0002418)2.42556115
47Molar tooth sign on MRI (HP:0002419)2.42556115
48Ventricular fibrillation (HP:0001663)2.41068407
49Abnormal hair laboratory examination (HP:0003328)2.40198304
50Pancreatic cysts (HP:0001737)2.39638826
51Occipital encephalocele (HP:0002085)2.35918292
52Epiphyseal dysplasia (HP:0002656)2.33624821
53Hypokalemic alkalosis (HP:0001949)2.30879374
54Abnormality of the renal medulla (HP:0100957)2.29625335
55Cystic liver disease (HP:0006706)2.26340009
56Nephronophthisis (HP:0000090)2.25160039
57Recurrent otitis media (HP:0000403)2.22360268
58Coarse facial features (HP:0000280)2.16448901
59Mild short stature (HP:0003502)2.15595202
60Atelectasis (HP:0100750)2.06971876
61Delayed epiphyseal ossification (HP:0002663)2.06850017
62Nephropathy (HP:0000112)2.02918955
63Chronic hepatic failure (HP:0100626)1.97986453
64Irregular epiphyses (HP:0010582)1.93411495
65Taurodontia (HP:0000679)1.90252859
66Abnormality of permanent molar morphology (HP:0011071)1.90252859
67Abnormality of the dental root (HP:0006486)1.90252859
68Abnormality of the dental pulp (HP:0006479)1.89549107
69Chronic otitis media (HP:0000389)1.88434348
70Gout (HP:0001997)1.78306101
71Bronchomalacia (HP:0002780)1.76417743
72Abnormality of molar (HP:0011077)1.75296402
73Abnormality of molar morphology (HP:0011070)1.75296402
74Medial flaring of the eyebrow (HP:0010747)1.71581668
75Neonatal respiratory distress (HP:0002643)1.69593563
76Abnormality of renal excretion (HP:0011036)1.69527669
77Male infertility (HP:0003251)1.66397405
78Hyponatremia (HP:0002902)1.66263169
79Postaxial foot polydactyly (HP:0001830)1.64077935
80Adrenal overactivity (HP:0002717)1.63097130
81Glomerulonephritis (HP:0000099)1.62685655
82Constipation (HP:0002019)1.62375404
83Abnormality of the renal cortex (HP:0011035)1.58656068
84Gait imbalance (HP:0002141)1.58194384
85Congenital hepatic fibrosis (HP:0002612)1.57892501
86Bifid scrotum (HP:0000048)1.56091990
87Congenital primary aphakia (HP:0007707)1.55637982
88Genu varum (HP:0002970)1.55156242
89Complement deficiency (HP:0004431)1.51986190
90Prolonged QT interval (HP:0001657)1.48051863
91Stage 5 chronic kidney disease (HP:0003774)1.45780936
92Male pseudohermaphroditism (HP:0000037)1.45151899
93Abnormality of sodium homeostasis (HP:0010931)1.42102238
94Furrowed tongue (HP:0000221)1.41421255
95Bell-shaped thorax (HP:0001591)1.39365748
96Neoplasm of the thyroid gland (HP:0100031)1.36948826
97Neurofibrillary tangles (HP:0002185)1.36743463
98Vascular calcification (HP:0004934)1.34421050
99Alkalosis (HP:0001948)1.34067740
100Hyperparathyroidism (HP:0000843)1.33558195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.84868636
2EPHA25.42916171
3MST43.69795362
4MAPKAPK32.76848781
5TRIB32.72761724
6MST1R2.50434019
7EPHA32.16426980
8AKT32.07352018
9NME11.86370798
10GRK11.68861374
11MET1.60103925
12TIE11.58895670
13MAP2K61.49375117
14PINK11.47958475
15LRRK21.43005081
16ZAP701.39961451
17FRK1.36442109
18DAPK21.30137569
19FER1.27796110
20MAP3K21.24633179
21LATS11.21585106
22NTRK31.21300411
23STK38L1.20609047
24ADRBK21.20024409
25CASK1.10102130
26ERBB21.09343158
27STK391.08754095
28STK241.05912612
29RPS6KA21.03185420
30NLK1.02164589
31MYLK0.96148323
32BMPR1B0.94266524
33ERBB30.89793835
34EPHB10.88549656
35PTK2B0.88209141
36CAMKK10.86006940
37NEK60.85862624
38STK380.81783345
39CDC42BPA0.81068402
40TLK10.80252558
41PDPK10.79899970
42TESK10.79708937
43FGFR30.79168866
44PNCK0.76235538
45MAP2K20.76180245
46OXSR10.74673653
47CAMKK20.74292815
48HIPK20.74128388
49DMPK0.73027190
50ERN10.72560803
51LMTK20.72312929
52PRKD10.70178433
53MARK20.68625449
54WNK40.66856526
55TRPM70.65610988
56PRKCE0.64239544
57PDGFRB0.63979680
58STK160.62261715
59ADRBK10.62224649
60PRKCZ0.59787052
61MAP3K70.59463448
62LIMK10.58825963
63BCR0.57969196
64MAPK130.57561462
65RET0.54897468
66MAPK120.53395057
67TGFBR20.53020021
68IGF1R0.52820743
69INSRR0.52570411
70KDR0.51076416
71MAP3K30.50975339
72EEF2K0.50694815
73RIPK40.50622586
74PRKCG0.48851967
75RIPK10.48138722
76PRKCD0.47713851
77PRKCQ0.47582870
78NEK90.46761425
79TYK20.46577689
80ACVR1B0.45799520
81PRKACA0.45694996
82ROCK10.45549341
83MAP4K20.45424437
84SGK4940.45370516
85SGK2230.45370516
86CAMK2A0.44603857
87PRKCA0.43915094
88RPS6KA60.43371069
89EGFR0.43023299
90CSNK1A10.42460070
91SGK20.41847859
92MAP3K40.41484821
93CAMK2G0.40963930
94ABL10.40152880
95TBK10.40011607
96ILK0.39017896
97SGK10.38835717
98PRKCI0.38745138
99TAOK30.37941887
100PAK30.37929818

Predicted pathways (KEGG)

RankGene SetZ-score
1Autoimmune thyroid disease_Homo sapiens_hsa053204.83055085
2Thyroid hormone synthesis_Homo sapiens_hsa049184.58625927
3Histidine metabolism_Homo sapiens_hsa003403.55668379
4Tyrosine metabolism_Homo sapiens_hsa003503.38334228
5Phenylalanine metabolism_Homo sapiens_hsa003602.44527864
6Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.36112961
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17924478
8beta-Alanine metabolism_Homo sapiens_hsa004102.12272955
9Chemical carcinogenesis_Homo sapiens_hsa052042.01094818
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.82922567
11Asthma_Homo sapiens_hsa053101.77689127
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.75509941
13Lysosome_Homo sapiens_hsa041421.64398535
14Gastric acid secretion_Homo sapiens_hsa049711.62037153
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.53805918
16Collecting duct acid secretion_Homo sapiens_hsa049661.50262075
17Tryptophan metabolism_Homo sapiens_hsa003801.47626548
18Salivary secretion_Homo sapiens_hsa049701.38782949
19Mineral absorption_Homo sapiens_hsa049781.37374226
20Allograft rejection_Homo sapiens_hsa053301.36847694
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.35561155
22Linoleic acid metabolism_Homo sapiens_hsa005911.34707641
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.31934719
24Type I diabetes mellitus_Homo sapiens_hsa049401.30771878
25Fatty acid degradation_Homo sapiens_hsa000711.30686827
26Circadian rhythm_Homo sapiens_hsa047101.29603018
27Staphylococcus aureus infection_Homo sapiens_hsa051501.28402519
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.26470188
29Glutathione metabolism_Homo sapiens_hsa004801.24619331
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23962269
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23300888
32Graft-versus-host disease_Homo sapiens_hsa053321.21716947
33Caffeine metabolism_Homo sapiens_hsa002321.20578047
34Ether lipid metabolism_Homo sapiens_hsa005651.19342215
35Retinol metabolism_Homo sapiens_hsa008301.19027101
36ABC transporters_Homo sapiens_hsa020101.18232318
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16339060
38Sphingolipid metabolism_Homo sapiens_hsa006001.12832217
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.11240774
40Arachidonic acid metabolism_Homo sapiens_hsa005901.10384428
41Complement and coagulation cascades_Homo sapiens_hsa046101.07917287
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04729265
43Tight junction_Homo sapiens_hsa045301.01493639
44Taste transduction_Homo sapiens_hsa047420.99543130
45ECM-receptor interaction_Homo sapiens_hsa045120.96412131
46Starch and sucrose metabolism_Homo sapiens_hsa005000.95569103
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95384459
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92092431
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91863075
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91680624
51Cocaine addiction_Homo sapiens_hsa050300.86719834
52Peroxisome_Homo sapiens_hsa041460.83504850
53Nicotine addiction_Homo sapiens_hsa050330.82146060
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.82017008
55Rheumatoid arthritis_Homo sapiens_hsa053230.81475901
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81215365
57Phagosome_Homo sapiens_hsa041450.80179880
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.79598561
59Huntingtons disease_Homo sapiens_hsa050160.77027364
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.76729499
61Protein digestion and absorption_Homo sapiens_hsa049740.74397536
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64643234
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63361192
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61399631
65Arginine and proline metabolism_Homo sapiens_hsa003300.60432419
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.60385252
67Antigen processing and presentation_Homo sapiens_hsa046120.58513078
68Bile secretion_Homo sapiens_hsa049760.58361388
69Glycerolipid metabolism_Homo sapiens_hsa005610.57103474
70Amphetamine addiction_Homo sapiens_hsa050310.56719237
71Pancreatic secretion_Homo sapiens_hsa049720.52162795
72Pertussis_Homo sapiens_hsa051330.51961403
73Vibrio cholerae infection_Homo sapiens_hsa051100.49279407
74Phototransduction_Homo sapiens_hsa047440.48992245
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.48969197
76Serotonergic synapse_Homo sapiens_hsa047260.48635979
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47757740
78Butanoate metabolism_Homo sapiens_hsa006500.47426610
79Glutamatergic synapse_Homo sapiens_hsa047240.45297692
80Insulin secretion_Homo sapiens_hsa049110.44113532
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44001336
82Cardiac muscle contraction_Homo sapiens_hsa042600.43138029
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.38564891
84cAMP signaling pathway_Homo sapiens_hsa040240.38087529
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37548283
86Viral myocarditis_Homo sapiens_hsa054160.36522697
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.36434126
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.34957684
89Propanoate metabolism_Homo sapiens_hsa006400.34501831
90Nitrogen metabolism_Homo sapiens_hsa009100.33300080
91Oxidative phosphorylation_Homo sapiens_hsa001900.32741115
92Circadian entrainment_Homo sapiens_hsa047130.30897417
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30546940
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.29292587
95Hematopoietic cell lineage_Homo sapiens_hsa046400.28314522
96Selenocompound metabolism_Homo sapiens_hsa004500.26330039
97Hepatitis C_Homo sapiens_hsa051600.25583884
98TGF-beta signaling pathway_Homo sapiens_hsa043500.24997573
99PPAR signaling pathway_Homo sapiens_hsa033200.24835804
100Metabolic pathways_Homo sapiens_hsa011000.23884854

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