

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.90479947 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.17385144 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.49637464 |
| 4 | ATP synthesis coupled proton transport (GO:0015986) | 4.49637464 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 4.41684843 |
| 6 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.33178801 |
| 7 | protein targeting to mitochondrion (GO:0006626) | 4.24606729 |
| 8 | rRNA modification (GO:0000154) | 4.23727522 |
| 9 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.21751798 |
| 10 | termination of RNA polymerase III transcription (GO:0006386) | 4.21751798 |
| 11 | pseudouridine synthesis (GO:0001522) | 4.20212635 |
| 12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.10670298 |
| 13 | metallo-sulfur cluster assembly (GO:0031163) | 4.08342896 |
| 14 | iron-sulfur cluster assembly (GO:0016226) | 4.08342896 |
| 15 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.06528081 |
| 16 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.04404487 |
| 17 | negative regulation of ligase activity (GO:0051352) | 4.04342670 |
| 18 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.04342670 |
| 19 | ribosome assembly (GO:0042255) | 4.02519587 |
| 20 | respiratory electron transport chain (GO:0022904) | 4.01448678 |
| 21 | ribosomal large subunit biogenesis (GO:0042273) | 3.99163484 |
| 22 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.99053609 |
| 23 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.98050916 |
| 24 | establishment of protein localization to mitochondrion (GO:0072655) | 3.95786122 |
| 25 | peptidyl-histidine modification (GO:0018202) | 3.94014105 |
| 26 | protein complex biogenesis (GO:0070271) | 3.92478658 |
| 27 | electron transport chain (GO:0022900) | 3.90943991 |
| 28 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.89369911 |
| 29 | maturation of SSU-rRNA (GO:0030490) | 3.88297077 |
| 30 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.87182600 |
| 31 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.83888176 |
| 32 | protein localization to mitochondrion (GO:0070585) | 3.83085498 |
| 33 | regulation of mitochondrial translation (GO:0070129) | 3.79271760 |
| 34 | ribosomal small subunit biogenesis (GO:0042274) | 3.79138877 |
| 35 | ribosomal small subunit assembly (GO:0000028) | 3.78441382 |
| 36 | DNA deamination (GO:0045006) | 3.75758832 |
| 37 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.75161055 |
| 38 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.72796247 |
| 39 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.68226095 |
| 40 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.66100880 |
| 41 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.66100880 |
| 42 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.64195082 |
| 43 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.64195082 |
| 44 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.64195082 |
| 45 | formation of translation preinitiation complex (GO:0001731) | 3.59968555 |
| 46 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.57516428 |
| 47 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.57516428 |
| 48 | NADH dehydrogenase complex assembly (GO:0010257) | 3.57516428 |
| 49 | spliceosomal snRNP assembly (GO:0000387) | 3.56173324 |
| 50 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.53376135 |
| 51 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.53376135 |
| 52 | positive regulation of ligase activity (GO:0051351) | 3.52699730 |
| 53 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.50963163 |
| 54 | rRNA processing (GO:0006364) | 3.49776789 |
| 55 | oxidative phosphorylation (GO:0006119) | 3.49437732 |
| 56 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.49383271 |
| 57 | translation (GO:0006412) | 3.49320407 |
| 58 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.48084546 |
| 59 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.46195846 |
| 60 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.44867357 |
| 61 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.44338967 |
| 62 | GDP-mannose metabolic process (GO:0019673) | 3.42760959 |
| 63 | protein deneddylation (GO:0000338) | 3.40937065 |
| 64 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.40454942 |
| 65 | cullin deneddylation (GO:0010388) | 3.38069896 |
| 66 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.37522190 |
| 67 | respiratory chain complex IV assembly (GO:0008535) | 3.36165618 |
| 68 | DNA strand elongation (GO:0022616) | 3.35519407 |
| 69 | cellular component biogenesis (GO:0044085) | 3.34602133 |
| 70 | rRNA metabolic process (GO:0016072) | 3.32611965 |
| 71 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.32084191 |
| 72 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.32084191 |
| 73 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.31696343 |
| 74 | transcription from mitochondrial promoter (GO:0006390) | 3.31620130 |
| 75 | protein maturation by protein folding (GO:0022417) | 3.30173773 |
| 76 | purine nucleobase biosynthetic process (GO:0009113) | 3.29437432 |
| 77 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.28964823 |
| 78 | maturation of 5.8S rRNA (GO:0000460) | 3.28730219 |
| 79 | establishment of integrated proviral latency (GO:0075713) | 3.27365545 |
| 80 | cytochrome complex assembly (GO:0017004) | 3.25451128 |
| 81 | GTP biosynthetic process (GO:0006183) | 3.24554944 |
| 82 | viral transcription (GO:0019083) | 3.23830420 |
| 83 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.21920462 |
| 84 | translational termination (GO:0006415) | 3.20691845 |
| 85 | cotranslational protein targeting to membrane (GO:0006613) | 3.19453133 |
| 86 | rRNA methylation (GO:0031167) | 3.17817221 |
| 87 | regulation of ligase activity (GO:0051340) | 3.17594797 |
| 88 | mitochondrial RNA metabolic process (GO:0000959) | 3.15799771 |
| 89 | base-excision repair, AP site formation (GO:0006285) | 3.12574928 |
| 90 | protein targeting to ER (GO:0045047) | 3.12440336 |
| 91 | establishment of viral latency (GO:0019043) | 3.10515480 |
| 92 | tRNA processing (GO:0008033) | 3.10313582 |
| 93 | deoxyribose phosphate catabolic process (GO:0046386) | 3.09649605 |
| 94 | ubiquinone metabolic process (GO:0006743) | 3.09317699 |
| 95 | deoxyribonucleotide catabolic process (GO:0009264) | 3.08803715 |
| 96 | pyrimidine nucleotide catabolic process (GO:0006244) | 3.08132746 |
| 97 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.07416736 |
| 98 | ribosome biogenesis (GO:0042254) | 3.07336584 |
| 99 | protein neddylation (GO:0045116) | 3.06199464 |
| 100 | translational initiation (GO:0006413) | 3.04471009 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.96159278 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.19925052 |
| 3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.19684548 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 4.14937396 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.00475251 |
| 6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.89717527 |
| 7 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.81698742 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.77119541 |
| 9 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.56504344 |
| 10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.38661027 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.17596276 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.13626879 |
| 13 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.05430133 |
| 14 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.96055847 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.85925985 |
| 16 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.79748525 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.72184021 |
| 18 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.67974868 |
| 19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.61831225 |
| 20 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.58406248 |
| 21 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.50144671 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.49405049 |
| 23 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.47489619 |
| 24 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.41350679 |
| 25 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.40866875 |
| 26 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.40624138 |
| 27 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.37999410 |
| 28 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.34696484 |
| 29 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.29421396 |
| 30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.28817184 |
| 31 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.21452324 |
| 32 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.16573981 |
| 33 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.15836653 |
| 34 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.07690841 |
| 35 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.91002143 |
| 36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.87127552 |
| 37 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.85813348 |
| 38 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.82312336 |
| 39 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.81268023 |
| 40 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.80911940 |
| 41 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.79415450 |
| 42 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.73660921 |
| 43 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.71331496 |
| 44 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.66006777 |
| 45 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.62865517 |
| 46 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.62562322 |
| 47 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.61562070 |
| 48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.60009616 |
| 49 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.55784791 |
| 50 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.54522984 |
| 51 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.52791074 |
| 52 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.52109700 |
| 53 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.49672403 |
| 54 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.48274831 |
| 55 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.46480589 |
| 56 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.44130347 |
| 57 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.40652371 |
| 58 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.40238941 |
| 59 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.37692094 |
| 60 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.33774261 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.33500857 |
| 62 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.30334796 |
| 63 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.27503252 |
| 64 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.24190476 |
| 65 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.23749830 |
| 66 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.21899974 |
| 67 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.21027075 |
| 68 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.17194957 |
| 69 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.15974886 |
| 70 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.13586542 |
| 71 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11830691 |
| 72 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.08880053 |
| 73 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.08487381 |
| 74 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.05167039 |
| 75 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.05046732 |
| 76 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.99743597 |
| 77 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.97107374 |
| 78 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.97000819 |
| 79 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95813036 |
| 80 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.94668764 |
| 81 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94322990 |
| 82 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.94105635 |
| 83 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.90419440 |
| 84 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.89874768 |
| 85 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.89135720 |
| 86 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.88958463 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.87384425 |
| 88 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.87126665 |
| 89 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86652272 |
| 90 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.85727023 |
| 91 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.84646886 |
| 92 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.84453485 |
| 93 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.81201293 |
| 94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.81043261 |
| 95 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.79401029 |
| 96 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.78617451 |
| 97 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75497844 |
| 98 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.75145372 |
| 99 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.72818824 |
| 100 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.72290740 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 4.24596826 |
| 2 | MP0003693_abnormal_embryo_hatching | 4.13451313 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.69275097 |
| 4 | MP0004957_abnormal_blastocyst_morpholog | 3.38048687 |
| 5 | MP0009379_abnormal_foot_pigmentation | 3.32041823 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 3.18608072 |
| 7 | MP0003111_abnormal_nucleus_morphology | 3.18258345 |
| 8 | MP0003186_abnormal_redox_activity | 2.90760204 |
| 9 | MP0003786_premature_aging | 2.89258988 |
| 10 | MP0006035_abnormal_mitochondrial_morpho | 2.87898148 |
| 11 | MP0006036_abnormal_mitochondrial_physio | 2.76125809 |
| 12 | MP0003077_abnormal_cell_cycle | 2.73327334 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.70069769 |
| 14 | MP0003718_maternal_effect | 2.56207464 |
| 15 | MP0001529_abnormal_vocalization | 2.14518145 |
| 16 | MP0008007_abnormal_cellular_replicative | 2.09852795 |
| 17 | MP0001188_hyperpigmentation | 2.03788452 |
| 18 | MP0002736_abnormal_nociception_after | 1.96586786 |
| 19 | MP0008995_early_reproductive_senescence | 1.86794767 |
| 20 | MP0000358_abnormal_cell_content/ | 1.75393324 |
| 21 | MP0009697_abnormal_copulation | 1.75171129 |
| 22 | MP0004147_increased_porphyrin_level | 1.74539596 |
| 23 | MP0006292_abnormal_olfactory_placode | 1.73554254 |
| 24 | MP0009333_abnormal_splenocyte_physiolog | 1.72021822 |
| 25 | MP0003646_muscle_fatigue | 1.66796594 |
| 26 | MP0008789_abnormal_olfactory_epithelium | 1.65365782 |
| 27 | MP0001727_abnormal_embryo_implantation | 1.65019034 |
| 28 | MP0001764_abnormal_homeostasis | 1.59293040 |
| 29 | MP0008260_abnormal_autophagy | 1.59139484 |
| 30 | MP0001730_embryonic_growth_arrest | 1.49376570 |
| 31 | MP0002160_abnormal_reproductive_system | 1.48596707 |
| 32 | MP0003123_paternal_imprinting | 1.47124647 |
| 33 | MP0001919_abnormal_reproductive_system | 1.40409491 |
| 34 | MP0005389_reproductive_system_phenotype | 1.37795991 |
| 35 | MP0000490_abnormal_crypts_of | 1.33339451 |
| 36 | MP0005394_taste/olfaction_phenotype | 1.31040656 |
| 37 | MP0005499_abnormal_olfactory_system | 1.31040656 |
| 38 | MP0002210_abnormal_sex_determination | 1.29501862 |
| 39 | MP0002102_abnormal_ear_morphology | 1.26241195 |
| 40 | MP0005451_abnormal_body_composition | 1.24250501 |
| 41 | MP0001968_abnormal_touch/_nociception | 1.24242136 |
| 42 | MP0000015_abnormal_ear_pigmentation | 1.22697662 |
| 43 | MP0000313_abnormal_cell_death | 1.21468849 |
| 44 | MP0000678_abnormal_parathyroid_gland | 1.21399204 |
| 45 | MP0001929_abnormal_gametogenesis | 1.19364095 |
| 46 | MP0001697_abnormal_embryo_size | 1.16444673 |
| 47 | MP0005075_abnormal_melanosome_morpholog | 1.15809879 |
| 48 | MP0000350_abnormal_cell_proliferation | 1.14443632 |
| 49 | MP0010307_abnormal_tumor_latency | 1.13252076 |
| 50 | MP0000647_abnormal_sebaceous_gland | 1.11597785 |
| 51 | MP0009840_abnormal_foam_cell | 1.06770233 |
| 52 | MP0002080_prenatal_lethality | 1.05494636 |
| 53 | MP0003121_genomic_imprinting | 1.00961285 |
| 54 | MP0000049_abnormal_middle_ear | 1.00619500 |
| 55 | MP0002837_dystrophic_cardiac_calcinosis | 1.00370750 |
| 56 | MP0001145_abnormal_male_reproductive | 0.99902101 |
| 57 | MP0010030_abnormal_orbit_morphology | 0.99876333 |
| 58 | MP0001672_abnormal_embryogenesis/_devel | 0.98729836 |
| 59 | MP0005380_embryogenesis_phenotype | 0.98729836 |
| 60 | MP0002653_abnormal_ependyma_morphology | 0.98532763 |
| 61 | MP0008875_abnormal_xenobiotic_pharmacok | 0.98379370 |
| 62 | MP0000653_abnormal_sex_gland | 0.97383036 |
| 63 | MP0002095_abnormal_skin_pigmentation | 0.96823585 |
| 64 | MP0001293_anophthalmia | 0.93966605 |
| 65 | MP0005636_abnormal_mineral_homeostasis | 0.93390222 |
| 66 | MP0001905_abnormal_dopamine_level | 0.91362432 |
| 67 | MP0002638_abnormal_pupillary_reflex | 0.90672356 |
| 68 | MP0002938_white_spotting | 0.89329233 |
| 69 | MP0000372_irregular_coat_pigmentation | 0.88945963 |
| 70 | MP0001881_abnormal_mammary_gland | 0.87727049 |
| 71 | MP0002019_abnormal_tumor_incidence | 0.84959016 |
| 72 | MP0001119_abnormal_female_reproductive | 0.84793941 |
| 73 | MP0002163_abnormal_gland_morphology | 0.84570401 |
| 74 | MP0005266_abnormal_metabolism | 0.83242480 |
| 75 | MP0003315_abnormal_perineum_morphology | 0.78757277 |
| 76 | MP0008877_abnormal_DNA_methylation | 0.77951249 |
| 77 | MP0003984_embryonic_growth_retardation | 0.77797132 |
| 78 | MP0003698_abnormal_male_reproductive | 0.77438065 |
| 79 | MP0002088_abnormal_embryonic_growth/wei | 0.77271902 |
| 80 | MP0002090_abnormal_vision | 0.72149096 |
| 81 | MP0005410_abnormal_fertilization | 0.70640954 |
| 82 | MP0002085_abnormal_embryonic_tissue | 0.70294769 |
| 83 | MP0001984_abnormal_olfaction | 0.69818063 |
| 84 | MP0002751_abnormal_autonomic_nervous | 0.69371681 |
| 85 | MP0005501_abnormal_skin_physiology | 0.69167823 |
| 86 | MP0008057_abnormal_DNA_replication | 0.68998011 |
| 87 | MP0002132_abnormal_respiratory_system | 0.68504811 |
| 88 | MP0008873_increased_physiological_sensi | 0.67994377 |
| 89 | MP0002161_abnormal_fertility/fecundity | 0.65799967 |
| 90 | MP0005647_abnormal_sex_gland | 0.65035610 |
| 91 | MP0001324_abnormal_eye_pigmentation | 0.64555669 |
| 92 | MP0005319_abnormal_enzyme/_coenzyme | 0.64307730 |
| 93 | MP0006276_abnormal_autonomic_nervous | 0.63488337 |
| 94 | MP0009046_muscle_twitch | 0.63356188 |
| 95 | MP0001853_heart_inflammation | 0.62312255 |
| 96 | MP0001346_abnormal_lacrimal_gland | 0.62283840 |
| 97 | MP0006072_abnormal_retinal_apoptosis | 0.62191201 |
| 98 | MP0003221_abnormal_cardiomyocyte_apopto | 0.61698111 |
| 99 | MP0003699_abnormal_female_reproductive | 0.60787924 |
| 100 | MP0005187_abnormal_penis_morphology | 0.60699476 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.53172858 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 5.38616884 |
| 3 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 5.09888591 |
| 4 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 5.09888591 |
| 5 | Acute encephalopathy (HP:0006846) | 4.88149590 |
| 6 | Mitochondrial inheritance (HP:0001427) | 4.61596476 |
| 7 | Hepatocellular necrosis (HP:0001404) | 4.52384895 |
| 8 | Increased CSF lactate (HP:0002490) | 4.50757504 |
| 9 | Progressive macrocephaly (HP:0004481) | 4.24678818 |
| 10 | Hepatic necrosis (HP:0002605) | 4.08585861 |
| 11 | Cerebral edema (HP:0002181) | 3.82467831 |
| 12 | Increased intramyocellular lipid droplets (HP:0012240) | 3.74755503 |
| 13 | Microvesicular hepatic steatosis (HP:0001414) | 3.72549652 |
| 14 | Increased serum lactate (HP:0002151) | 3.71240927 |
| 15 | Lactic acidosis (HP:0003128) | 3.62029014 |
| 16 | Increased serum pyruvate (HP:0003542) | 3.51030913 |
| 17 | Increased hepatocellular lipid droplets (HP:0006565) | 3.47239136 |
| 18 | 3-Methylglutaconic aciduria (HP:0003535) | 3.42793872 |
| 19 | Lipid accumulation in hepatocytes (HP:0006561) | 3.26994858 |
| 20 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.26451121 |
| 21 | Increased muscle lipid content (HP:0009058) | 3.20613422 |
| 22 | Aplastic anemia (HP:0001915) | 3.13216220 |
| 23 | Abnormality of glycolysis (HP:0004366) | 3.12200038 |
| 24 | Exercise intolerance (HP:0003546) | 3.11748795 |
| 25 | Ragged-red muscle fibers (HP:0003200) | 2.99895634 |
| 26 | Renal Fanconi syndrome (HP:0001994) | 2.98560675 |
| 27 | Type I transferrin isoform profile (HP:0003642) | 2.93402228 |
| 28 | Respiratory failure (HP:0002878) | 2.88366056 |
| 29 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.87571110 |
| 30 | Reticulocytopenia (HP:0001896) | 2.86852445 |
| 31 | Abnormal number of erythroid precursors (HP:0012131) | 2.84282879 |
| 32 | Microretrognathia (HP:0000308) | 2.84226325 |
| 33 | Abnormal protein glycosylation (HP:0012346) | 2.75918711 |
| 34 | Abnormal glycosylation (HP:0012345) | 2.75918711 |
| 35 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.75918711 |
| 36 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.75918711 |
| 37 | Abnormality of alanine metabolism (HP:0010916) | 2.75714055 |
| 38 | Hyperalaninemia (HP:0003348) | 2.75714055 |
| 39 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.75714055 |
| 40 | Cerebral hypomyelination (HP:0006808) | 2.72751018 |
| 41 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.70940619 |
| 42 | Reduced antithrombin III activity (HP:0001976) | 2.65616839 |
| 43 | Generalized aminoaciduria (HP:0002909) | 2.59746832 |
| 44 | Lethargy (HP:0001254) | 2.55167362 |
| 45 | Pancytopenia (HP:0001876) | 2.54778401 |
| 46 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.41567580 |
| 47 | Leukodystrophy (HP:0002415) | 2.39819187 |
| 48 | Progressive muscle weakness (HP:0003323) | 2.35259257 |
| 49 | Methylmalonic aciduria (HP:0012120) | 2.33743433 |
| 50 | Macrocytic anemia (HP:0001972) | 2.25252641 |
| 51 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.24733575 |
| 52 | Optic disc pallor (HP:0000543) | 2.23240162 |
| 53 | Rough bone trabeculation (HP:0100670) | 2.21891256 |
| 54 | Oral leukoplakia (HP:0002745) | 2.20746270 |
| 55 | Testicular atrophy (HP:0000029) | 2.18363983 |
| 56 | CNS demyelination (HP:0007305) | 2.09312129 |
| 57 | Sensory axonal neuropathy (HP:0003390) | 2.08790835 |
| 58 | Birth length less than 3rd percentile (HP:0003561) | 2.08691456 |
| 59 | Absent thumb (HP:0009777) | 2.08657840 |
| 60 | Emotional lability (HP:0000712) | 2.08516700 |
| 61 | Dicarboxylic aciduria (HP:0003215) | 2.05971703 |
| 62 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.05971703 |
| 63 | Horseshoe kidney (HP:0000085) | 2.05796483 |
| 64 | Meckel diverticulum (HP:0002245) | 2.03895316 |
| 65 | Abnormality of the preputium (HP:0100587) | 2.01775540 |
| 66 | Exertional dyspnea (HP:0002875) | 1.99983052 |
| 67 | Respiratory difficulties (HP:0002880) | 1.98990016 |
| 68 | Abnormality of the ileum (HP:0001549) | 1.94738912 |
| 69 | Abnormality of serum amino acid levels (HP:0003112) | 1.94244883 |
| 70 | Multiple enchondromatosis (HP:0005701) | 1.90114744 |
| 71 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.89653910 |
| 72 | Methylmalonic acidemia (HP:0002912) | 1.89056741 |
| 73 | Retinal dysplasia (HP:0007973) | 1.88267032 |
| 74 | Abnormal trabecular bone morphology (HP:0100671) | 1.87035643 |
| 75 | Pancreatic cysts (HP:0001737) | 1.86159240 |
| 76 | Abnormality of the anterior horn cell (HP:0006802) | 1.85294571 |
| 77 | Degeneration of anterior horn cells (HP:0002398) | 1.85294571 |
| 78 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.84656691 |
| 79 | X-linked dominant inheritance (HP:0001423) | 1.82796418 |
| 80 | CNS hypomyelination (HP:0003429) | 1.82144748 |
| 81 | Cleft eyelid (HP:0000625) | 1.81044804 |
| 82 | Patent foramen ovale (HP:0001655) | 1.80416371 |
| 83 | Chromsome breakage (HP:0040012) | 1.78961613 |
| 84 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.75375294 |
| 85 | Hypergonadotropic hypogonadism (HP:0000815) | 1.75271201 |
| 86 | Hyperglycinemia (HP:0002154) | 1.75237702 |
| 87 | Pallor (HP:0000980) | 1.71532871 |
| 88 | Secondary amenorrhea (HP:0000869) | 1.70350295 |
| 89 | Premature ovarian failure (HP:0008209) | 1.70204098 |
| 90 | Severe visual impairment (HP:0001141) | 1.69745879 |
| 91 | Blindness (HP:0000618) | 1.69036545 |
| 92 | Sparse eyelashes (HP:0000653) | 1.69015672 |
| 93 | Glycosuria (HP:0003076) | 1.67106398 |
| 94 | Abnormality of urine glucose concentration (HP:0011016) | 1.67106398 |
| 95 | Hypokinesia (HP:0002375) | 1.66747279 |
| 96 | Postnatal microcephaly (HP:0005484) | 1.65804295 |
| 97 | Gliosis (HP:0002171) | 1.63711198 |
| 98 | Hypoplasia of the uterus (HP:0000013) | 1.63317574 |
| 99 | Progressive microcephaly (HP:0000253) | 1.61461953 |
| 100 | Death in infancy (HP:0001522) | 1.60817809 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME2 | 4.11126462 |
| 2 | BUB1 | 3.75228174 |
| 3 | VRK2 | 3.73743973 |
| 4 | TESK2 | 3.33132454 |
| 5 | SRPK1 | 3.18555730 |
| 6 | BCKDK | 3.08753947 |
| 7 | NEK1 | 2.66542560 |
| 8 | PBK | 2.66125332 |
| 9 | CDC7 | 2.65533571 |
| 10 | PIM2 | 2.43338876 |
| 11 | ARAF | 2.30068893 |
| 12 | NME1 | 2.13639951 |
| 13 | ZAK | 2.11864113 |
| 14 | LIMK1 | 2.09324090 |
| 15 | MST4 | 2.06695053 |
| 16 | TESK1 | 2.06278255 |
| 17 | EIF2AK1 | 2.00373385 |
| 18 | STK16 | 1.95645458 |
| 19 | VRK1 | 1.94214198 |
| 20 | MAP4K2 | 1.91382152 |
| 21 | EIF2AK3 | 1.83714101 |
| 22 | PDK2 | 1.82103957 |
| 23 | TRIM28 | 1.73654127 |
| 24 | KDR | 1.70393550 |
| 25 | AURKA | 1.54296860 |
| 26 | SCYL2 | 1.35911402 |
| 27 | PLK1 | 1.35832695 |
| 28 | CSNK1G3 | 1.33353787 |
| 29 | TTK | 1.31452706 |
| 30 | BRSK1 | 1.30703829 |
| 31 | NUAK1 | 1.29221344 |
| 32 | TSSK6 | 1.25093747 |
| 33 | IRAK3 | 1.22189676 |
| 34 | CSNK1G1 | 1.14178360 |
| 35 | ATR | 1.08023773 |
| 36 | WEE1 | 1.06947675 |
| 37 | AURKB | 1.06361288 |
| 38 | DAPK1 | 1.05809308 |
| 39 | CDK19 | 1.05626980 |
| 40 | ACVR1B | 1.04639857 |
| 41 | PLK4 | 1.02703703 |
| 42 | PLK3 | 1.02109736 |
| 43 | RPS6KA5 | 1.01598365 |
| 44 | TLK1 | 0.98903736 |
| 45 | ABL2 | 0.97372456 |
| 46 | CSNK1A1L | 0.93160535 |
| 47 | CDK8 | 0.92982531 |
| 48 | BRAF | 0.87137109 |
| 49 | DYRK2 | 0.86225363 |
| 50 | WNK3 | 0.83195607 |
| 51 | MAP2K7 | 0.82717814 |
| 52 | BRSK2 | 0.82673781 |
| 53 | CSNK2A1 | 0.78584811 |
| 54 | CSNK1G2 | 0.78080636 |
| 55 | CDK7 | 0.78048917 |
| 56 | CHEK2 | 0.76944620 |
| 57 | MAP3K11 | 0.76454859 |
| 58 | PRKCI | 0.75499341 |
| 59 | RAF1 | 0.74648722 |
| 60 | ILK | 0.74096747 |
| 61 | MAP3K12 | 0.73251655 |
| 62 | CCNB1 | 0.72198874 |
| 63 | RPS6KA4 | 0.71341654 |
| 64 | CSNK2A2 | 0.69319686 |
| 65 | DYRK3 | 0.69249062 |
| 66 | TAOK3 | 0.68607355 |
| 67 | PAK1 | 0.67389978 |
| 68 | MAPKAPK3 | 0.66813224 |
| 69 | CHEK1 | 0.66279843 |
| 70 | FLT3 | 0.57003103 |
| 71 | EPHA2 | 0.54422548 |
| 72 | DAPK3 | 0.52875173 |
| 73 | PIM1 | 0.52309357 |
| 74 | STK4 | 0.47309406 |
| 75 | AKT2 | 0.46332851 |
| 76 | LRRK2 | 0.43490914 |
| 77 | CAMK2G | 0.42294912 |
| 78 | TAOK2 | 0.40934670 |
| 79 | ERBB3 | 0.40526205 |
| 80 | ATM | 0.40519197 |
| 81 | CLK1 | 0.37998648 |
| 82 | RPS6KB2 | 0.37097595 |
| 83 | EIF2AK2 | 0.36415212 |
| 84 | PAK4 | 0.35509991 |
| 85 | MKNK1 | 0.34267896 |
| 86 | GRK7 | 0.32121607 |
| 87 | WNK4 | 0.31283297 |
| 88 | CSNK1A1 | 0.30001331 |
| 89 | BMPR1B | 0.29299218 |
| 90 | MAP3K8 | 0.28864082 |
| 91 | TXK | 0.28691140 |
| 92 | CDK2 | 0.28245947 |
| 93 | ADRBK2 | 0.25225546 |
| 94 | MAP3K5 | 0.23759289 |
| 95 | CDK14 | 0.23657380 |
| 96 | ERBB4 | 0.22717277 |
| 97 | CDK1 | 0.22602332 |
| 98 | IKBKB | 0.22221541 |
| 99 | PINK1 | 0.22100056 |
| 100 | STK39 | 0.21283017 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.30243359 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.54145054 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.53963343 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.40059950 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 3.13725993 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.11151365 |
| 7 | Mismatch repair_Homo sapiens_hsa03430 | 2.94641653 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.88091605 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.54637822 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.44334807 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.37799339 |
| 12 | Huntingtons disease_Homo sapiens_hsa05016 | 2.23165559 |
| 13 | Sulfur relay system_Homo sapiens_hsa04122 | 2.22134032 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.14512334 |
| 15 | Spliceosome_Homo sapiens_hsa03040 | 2.11425700 |
| 16 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.97169578 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.96904704 |
| 18 | Alzheimers disease_Homo sapiens_hsa05010 | 1.89318164 |
| 19 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.88415874 |
| 20 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.80421829 |
| 21 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.72966574 |
| 22 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.69445452 |
| 23 | RNA transport_Homo sapiens_hsa03013 | 1.68295158 |
| 24 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.66925481 |
| 25 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.63992492 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.62299489 |
| 27 | Basal transcription factors_Homo sapiens_hsa03022 | 1.48153488 |
| 28 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.46478909 |
| 29 | RNA degradation_Homo sapiens_hsa03018 | 1.42358406 |
| 30 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.42078431 |
| 31 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.40459934 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.37301392 |
| 33 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.36847204 |
| 34 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.31503065 |
| 35 | Purine metabolism_Homo sapiens_hsa00230 | 1.29542204 |
| 36 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.24367595 |
| 37 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.23788890 |
| 38 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.11395828 |
| 39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.10599618 |
| 40 | Cell cycle_Homo sapiens_hsa04110 | 1.08751703 |
| 41 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.07492659 |
| 42 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.07233958 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.03741655 |
| 44 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.02894288 |
| 45 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.01080665 |
| 46 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.00594444 |
| 47 | Carbon metabolism_Homo sapiens_hsa01200 | 0.98463743 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.94507266 |
| 49 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.93154077 |
| 50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.93044552 |
| 51 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.88925083 |
| 52 | Metabolic pathways_Homo sapiens_hsa01100 | 0.82316693 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.78915591 |
| 54 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.78002116 |
| 55 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.76385442 |
| 56 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.75786588 |
| 57 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.72779815 |
| 58 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.72481432 |
| 59 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.69293523 |
| 60 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.67220385 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.65811660 |
| 62 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.64546250 |
| 63 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.63649203 |
| 64 | Peroxisome_Homo sapiens_hsa04146 | 0.61683783 |
| 65 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61201262 |
| 66 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.60494420 |
| 67 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.53368575 |
| 68 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53279999 |
| 69 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.51314265 |
| 70 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.49173074 |
| 71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46749351 |
| 72 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.46604269 |
| 73 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.43567930 |
| 74 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.42987063 |
| 75 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.41568641 |
| 76 | Galactose metabolism_Homo sapiens_hsa00052 | 0.39698474 |
| 77 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.39378462 |
| 78 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.39251419 |
| 79 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.37325389 |
| 80 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.36796457 |
| 81 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.34312374 |
| 82 | Legionellosis_Homo sapiens_hsa05134 | 0.32066246 |
| 83 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.31634341 |
| 84 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.31229711 |
| 85 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.30616076 |
| 86 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.29220622 |
| 87 | Alcoholism_Homo sapiens_hsa05034 | 0.23645585 |
| 88 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.21192627 |
| 89 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.19277583 |
| 90 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.18733320 |
| 91 | Shigellosis_Homo sapiens_hsa05131 | 0.17571195 |
| 92 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.16998241 |
| 93 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.13886345 |
| 94 | Phototransduction_Homo sapiens_hsa04744 | 0.12633597 |
| 95 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.09439651 |
| 96 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.09180848 |
| 97 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.08476057 |
| 98 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.07564606 |
| 99 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.06119532 |
| 100 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.05829664 |

