C16ORF91

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.90479947
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.17385144
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49637464
4ATP synthesis coupled proton transport (GO:0015986)4.49637464
5chaperone-mediated protein transport (GO:0072321)4.41684843
6negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.33178801
7protein targeting to mitochondrion (GO:0006626)4.24606729
8rRNA modification (GO:0000154)4.23727522
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.21751798
10termination of RNA polymerase III transcription (GO:0006386)4.21751798
11pseudouridine synthesis (GO:0001522)4.20212635
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.10670298
13metallo-sulfur cluster assembly (GO:0031163)4.08342896
14iron-sulfur cluster assembly (GO:0016226)4.08342896
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.06528081
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.04404487
17negative regulation of ligase activity (GO:0051352)4.04342670
18negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.04342670
19ribosome assembly (GO:0042255)4.02519587
20respiratory electron transport chain (GO:0022904)4.01448678
21ribosomal large subunit biogenesis (GO:0042273)3.99163484
22establishment of protein localization to mitochondrial membrane (GO:0090151)3.99053609
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.98050916
24establishment of protein localization to mitochondrion (GO:0072655)3.95786122
25peptidyl-histidine modification (GO:0018202)3.94014105
26protein complex biogenesis (GO:0070271)3.92478658
27electron transport chain (GO:0022900)3.90943991
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.89369911
29maturation of SSU-rRNA (GO:0030490)3.88297077
30regulation of cellular amino acid metabolic process (GO:0006521)3.87182600
31mitochondrial respiratory chain complex assembly (GO:0033108)3.83888176
32protein localization to mitochondrion (GO:0070585)3.83085498
33regulation of mitochondrial translation (GO:0070129)3.79271760
34ribosomal small subunit biogenesis (GO:0042274)3.79138877
35ribosomal small subunit assembly (GO:0000028)3.78441382
36DNA deamination (GO:0045006)3.75758832
37DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.75161055
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72796247
39positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.68226095
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.66100880
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.66100880
42signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.64195082
43signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.64195082
44signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.64195082
45formation of translation preinitiation complex (GO:0001731)3.59968555
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57516428
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.57516428
48NADH dehydrogenase complex assembly (GO:0010257)3.57516428
49spliceosomal snRNP assembly (GO:0000387)3.56173324
50signal transduction involved in DNA damage checkpoint (GO:0072422)3.53376135
51signal transduction involved in DNA integrity checkpoint (GO:0072401)3.53376135
52positive regulation of ligase activity (GO:0051351)3.52699730
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.50963163
54rRNA processing (GO:0006364)3.49776789
55oxidative phosphorylation (GO:0006119)3.49437732
56nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.49383271
57translation (GO:0006412)3.49320407
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.48084546
59DNA strand elongation involved in DNA replication (GO:0006271)3.46195846
60telomere maintenance via semi-conservative replication (GO:0032201)3.44867357
61guanosine-containing compound biosynthetic process (GO:1901070)3.44338967
62GDP-mannose metabolic process (GO:0019673)3.42760959
63protein deneddylation (GO:0000338)3.40937065
64deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.40454942
65cullin deneddylation (GO:0010388)3.38069896
66ribonucleoprotein complex biogenesis (GO:0022613)3.37522190
67respiratory chain complex IV assembly (GO:0008535)3.36165618
68DNA strand elongation (GO:0022616)3.35519407
69cellular component biogenesis (GO:0044085)3.34602133
70rRNA metabolic process (GO:0016072)3.32611965
71tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.32084191
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.32084191
73pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.31696343
74transcription from mitochondrial promoter (GO:0006390)3.31620130
75protein maturation by protein folding (GO:0022417)3.30173773
76purine nucleobase biosynthetic process (GO:0009113)3.29437432
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.28964823
78maturation of 5.8S rRNA (GO:0000460)3.28730219
79establishment of integrated proviral latency (GO:0075713)3.27365545
80cytochrome complex assembly (GO:0017004)3.25451128
81GTP biosynthetic process (GO:0006183)3.24554944
82viral transcription (GO:0019083)3.23830420
83SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.21920462
84translational termination (GO:0006415)3.20691845
85cotranslational protein targeting to membrane (GO:0006613)3.19453133
86rRNA methylation (GO:0031167)3.17817221
87regulation of ligase activity (GO:0051340)3.17594797
88mitochondrial RNA metabolic process (GO:0000959)3.15799771
89base-excision repair, AP site formation (GO:0006285)3.12574928
90protein targeting to ER (GO:0045047)3.12440336
91establishment of viral latency (GO:0019043)3.10515480
92tRNA processing (GO:0008033)3.10313582
93deoxyribose phosphate catabolic process (GO:0046386)3.09649605
94ubiquinone metabolic process (GO:0006743)3.09317699
95deoxyribonucleotide catabolic process (GO:0009264)3.08803715
96pyrimidine nucleotide catabolic process (GO:0006244)3.08132746
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07416736
98ribosome biogenesis (GO:0042254)3.07336584
99protein neddylation (GO:0045116)3.06199464
100translational initiation (GO:0006413)3.04471009

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.96159278
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.19925052
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.19684548
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.14937396
5E2F7_22180533_ChIP-Seq_HELA_Human4.00475251
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.89717527
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.81698742
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.77119541
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56504344
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.38661027
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17596276
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13626879
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.05430133
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96055847
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85925985
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.79748525
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72184021
18VDR_23849224_ChIP-Seq_CD4+_Human2.67974868
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.61831225
20DCP1A_22483619_ChIP-Seq_HELA_Human2.58406248
21GABP_19822575_ChIP-Seq_HepG2_Human2.50144671
22FOXP3_21729870_ChIP-Seq_TREG_Human2.49405049
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47489619
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41350679
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40866875
26XRN2_22483619_ChIP-Seq_HELA_Human2.40624138
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.37999410
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.34696484
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.29421396
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28817184
31ELK1_19687146_ChIP-ChIP_HELA_Human2.21452324
32TTF2_22483619_ChIP-Seq_HELA_Human2.16573981
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.15836653
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07690841
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.91002143
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87127552
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85813348
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82312336
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81268023
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80911940
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.79415450
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73660921
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71331496
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66006777
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62865517
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.62562322
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.61562070
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60009616
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55784791
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.54522984
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.52791074
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.52109700
53KDM5A_27292631_Chip-Seq_BREAST_Human1.49672403
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.48274831
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46480589
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.44130347
57MYC_18940864_ChIP-ChIP_HL60_Human1.40652371
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40238941
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37692094
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33774261
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33500857
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.30334796
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27503252
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24190476
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23749830
66CIITA_25753668_ChIP-Seq_RAJI_Human1.21899974
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21027075
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17194957
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15974886
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.13586542
71TFEB_21752829_ChIP-Seq_HELA_Human1.11830691
72ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08880053
73AR_21909140_ChIP-Seq_LNCAP_Human1.08487381
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05167039
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05046732
76ZNF263_19887448_ChIP-Seq_K562_Human0.99743597
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97107374
78FOXP1_21924763_ChIP-Seq_HESCs_Human0.97000819
79CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95813036
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94668764
81CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94322990
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94105635
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90419440
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89874768
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89135720
86KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88958463
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87384425
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.87126665
89CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86652272
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85727023
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84646886
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84453485
93TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81201293
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81043261
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79401029
96SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78617451
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.75497844
98SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75145372
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.72818824
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72290740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair4.24596826
2MP0003693_abnormal_embryo_hatching4.13451313
3MP0010094_abnormal_chromosome_stability3.69275097
4MP0004957_abnormal_blastocyst_morpholog3.38048687
5MP0009379_abnormal_foot_pigmentation3.32041823
6MP0003806_abnormal_nucleotide_metabolis3.18608072
7MP0003111_abnormal_nucleus_morphology3.18258345
8MP0003186_abnormal_redox_activity2.90760204
9MP0003786_premature_aging2.89258988
10MP0006035_abnormal_mitochondrial_morpho2.87898148
11MP0006036_abnormal_mitochondrial_physio2.76125809
12MP0003077_abnormal_cell_cycle2.73327334
13MP0008932_abnormal_embryonic_tissue2.70069769
14MP0003718_maternal_effect2.56207464
15MP0001529_abnormal_vocalization2.14518145
16MP0008007_abnormal_cellular_replicative2.09852795
17MP0001188_hyperpigmentation2.03788452
18MP0002736_abnormal_nociception_after1.96586786
19MP0008995_early_reproductive_senescence1.86794767
20MP0000358_abnormal_cell_content/1.75393324
21MP0009697_abnormal_copulation1.75171129
22MP0004147_increased_porphyrin_level1.74539596
23MP0006292_abnormal_olfactory_placode1.73554254
24MP0009333_abnormal_splenocyte_physiolog1.72021822
25MP0003646_muscle_fatigue1.66796594
26MP0008789_abnormal_olfactory_epithelium1.65365782
27MP0001727_abnormal_embryo_implantation1.65019034
28MP0001764_abnormal_homeostasis1.59293040
29MP0008260_abnormal_autophagy1.59139484
30MP0001730_embryonic_growth_arrest1.49376570
31MP0002160_abnormal_reproductive_system1.48596707
32MP0003123_paternal_imprinting1.47124647
33MP0001919_abnormal_reproductive_system1.40409491
34MP0005389_reproductive_system_phenotype1.37795991
35MP0000490_abnormal_crypts_of1.33339451
36MP0005394_taste/olfaction_phenotype1.31040656
37MP0005499_abnormal_olfactory_system1.31040656
38MP0002210_abnormal_sex_determination1.29501862
39MP0002102_abnormal_ear_morphology1.26241195
40MP0005451_abnormal_body_composition1.24250501
41MP0001968_abnormal_touch/_nociception1.24242136
42MP0000015_abnormal_ear_pigmentation1.22697662
43MP0000313_abnormal_cell_death1.21468849
44MP0000678_abnormal_parathyroid_gland1.21399204
45MP0001929_abnormal_gametogenesis1.19364095
46MP0001697_abnormal_embryo_size1.16444673
47MP0005075_abnormal_melanosome_morpholog1.15809879
48MP0000350_abnormal_cell_proliferation1.14443632
49MP0010307_abnormal_tumor_latency1.13252076
50MP0000647_abnormal_sebaceous_gland1.11597785
51MP0009840_abnormal_foam_cell1.06770233
52MP0002080_prenatal_lethality1.05494636
53MP0003121_genomic_imprinting1.00961285
54MP0000049_abnormal_middle_ear1.00619500
55MP0002837_dystrophic_cardiac_calcinosis1.00370750
56MP0001145_abnormal_male_reproductive0.99902101
57MP0010030_abnormal_orbit_morphology0.99876333
58MP0001672_abnormal_embryogenesis/_devel0.98729836
59MP0005380_embryogenesis_phenotype0.98729836
60MP0002653_abnormal_ependyma_morphology0.98532763
61MP0008875_abnormal_xenobiotic_pharmacok0.98379370
62MP0000653_abnormal_sex_gland0.97383036
63MP0002095_abnormal_skin_pigmentation0.96823585
64MP0001293_anophthalmia0.93966605
65MP0005636_abnormal_mineral_homeostasis0.93390222
66MP0001905_abnormal_dopamine_level0.91362432
67MP0002638_abnormal_pupillary_reflex0.90672356
68MP0002938_white_spotting0.89329233
69MP0000372_irregular_coat_pigmentation0.88945963
70MP0001881_abnormal_mammary_gland0.87727049
71MP0002019_abnormal_tumor_incidence0.84959016
72MP0001119_abnormal_female_reproductive0.84793941
73MP0002163_abnormal_gland_morphology0.84570401
74MP0005266_abnormal_metabolism0.83242480
75MP0003315_abnormal_perineum_morphology0.78757277
76MP0008877_abnormal_DNA_methylation0.77951249
77MP0003984_embryonic_growth_retardation0.77797132
78MP0003698_abnormal_male_reproductive0.77438065
79MP0002088_abnormal_embryonic_growth/wei0.77271902
80MP0002090_abnormal_vision0.72149096
81MP0005410_abnormal_fertilization0.70640954
82MP0002085_abnormal_embryonic_tissue0.70294769
83MP0001984_abnormal_olfaction0.69818063
84MP0002751_abnormal_autonomic_nervous0.69371681
85MP0005501_abnormal_skin_physiology0.69167823
86MP0008057_abnormal_DNA_replication0.68998011
87MP0002132_abnormal_respiratory_system0.68504811
88MP0008873_increased_physiological_sensi0.67994377
89MP0002161_abnormal_fertility/fecundity0.65799967
90MP0005647_abnormal_sex_gland0.65035610
91MP0001324_abnormal_eye_pigmentation0.64555669
92MP0005319_abnormal_enzyme/_coenzyme0.64307730
93MP0006276_abnormal_autonomic_nervous0.63488337
94MP0009046_muscle_twitch0.63356188
95MP0001853_heart_inflammation0.62312255
96MP0001346_abnormal_lacrimal_gland0.62283840
97MP0006072_abnormal_retinal_apoptosis0.62191201
98MP0003221_abnormal_cardiomyocyte_apopto0.61698111
99MP0003699_abnormal_female_reproductive0.60787924
100MP0005187_abnormal_penis_morphology0.60699476

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.53172858
2Acute necrotizing encephalopathy (HP:0006965)5.38616884
3Decreased activity of mitochondrial respiratory chain (HP:0008972)5.09888591
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.09888591
5Acute encephalopathy (HP:0006846)4.88149590
6Mitochondrial inheritance (HP:0001427)4.61596476
7Hepatocellular necrosis (HP:0001404)4.52384895
8Increased CSF lactate (HP:0002490)4.50757504
9Progressive macrocephaly (HP:0004481)4.24678818
10Hepatic necrosis (HP:0002605)4.08585861
11Cerebral edema (HP:0002181)3.82467831
12Increased intramyocellular lipid droplets (HP:0012240)3.74755503
13Microvesicular hepatic steatosis (HP:0001414)3.72549652
14Increased serum lactate (HP:0002151)3.71240927
15Lactic acidosis (HP:0003128)3.62029014
16Increased serum pyruvate (HP:0003542)3.51030913
17Increased hepatocellular lipid droplets (HP:0006565)3.47239136
183-Methylglutaconic aciduria (HP:0003535)3.42793872
19Lipid accumulation in hepatocytes (HP:0006561)3.26994858
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.26451121
21Increased muscle lipid content (HP:0009058)3.20613422
22Aplastic anemia (HP:0001915)3.13216220
23Abnormality of glycolysis (HP:0004366)3.12200038
24Exercise intolerance (HP:0003546)3.11748795
25Ragged-red muscle fibers (HP:0003200)2.99895634
26Renal Fanconi syndrome (HP:0001994)2.98560675
27Type I transferrin isoform profile (HP:0003642)2.93402228
28Respiratory failure (HP:0002878)2.88366056
29Abnormality of cells of the erythroid lineage (HP:0012130)2.87571110
30Reticulocytopenia (HP:0001896)2.86852445
31Abnormal number of erythroid precursors (HP:0012131)2.84282879
32Microretrognathia (HP:0000308)2.84226325
33Abnormal protein glycosylation (HP:0012346)2.75918711
34Abnormal glycosylation (HP:0012345)2.75918711
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75918711
36Abnormal protein N-linked glycosylation (HP:0012347)2.75918711
37Abnormality of alanine metabolism (HP:0010916)2.75714055
38Hyperalaninemia (HP:0003348)2.75714055
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75714055
40Cerebral hypomyelination (HP:0006808)2.72751018
41Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.70940619
42Reduced antithrombin III activity (HP:0001976)2.65616839
43Generalized aminoaciduria (HP:0002909)2.59746832
44Lethargy (HP:0001254)2.55167362
45Pancytopenia (HP:0001876)2.54778401
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41567580
47Leukodystrophy (HP:0002415)2.39819187
48Progressive muscle weakness (HP:0003323)2.35259257
49Methylmalonic aciduria (HP:0012120)2.33743433
50Macrocytic anemia (HP:0001972)2.25252641
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24733575
52Optic disc pallor (HP:0000543)2.23240162
53Rough bone trabeculation (HP:0100670)2.21891256
54Oral leukoplakia (HP:0002745)2.20746270
55Testicular atrophy (HP:0000029)2.18363983
56CNS demyelination (HP:0007305)2.09312129
57Sensory axonal neuropathy (HP:0003390)2.08790835
58Birth length less than 3rd percentile (HP:0003561)2.08691456
59Absent thumb (HP:0009777)2.08657840
60Emotional lability (HP:0000712)2.08516700
61Dicarboxylic aciduria (HP:0003215)2.05971703
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05971703
63Horseshoe kidney (HP:0000085)2.05796483
64Meckel diverticulum (HP:0002245)2.03895316
65Abnormality of the preputium (HP:0100587)2.01775540
66Exertional dyspnea (HP:0002875)1.99983052
67Respiratory difficulties (HP:0002880)1.98990016
68Abnormality of the ileum (HP:0001549)1.94738912
69Abnormality of serum amino acid levels (HP:0003112)1.94244883
70Multiple enchondromatosis (HP:0005701)1.90114744
71Aplasia/hypoplasia of the uterus (HP:0008684)1.89653910
72Methylmalonic acidemia (HP:0002912)1.89056741
73Retinal dysplasia (HP:0007973)1.88267032
74Abnormal trabecular bone morphology (HP:0100671)1.87035643
75Pancreatic cysts (HP:0001737)1.86159240
76Abnormality of the anterior horn cell (HP:0006802)1.85294571
77Degeneration of anterior horn cells (HP:0002398)1.85294571
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84656691
79X-linked dominant inheritance (HP:0001423)1.82796418
80CNS hypomyelination (HP:0003429)1.82144748
81Cleft eyelid (HP:0000625)1.81044804
82Patent foramen ovale (HP:0001655)1.80416371
83Chromsome breakage (HP:0040012)1.78961613
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.75375294
85Hypergonadotropic hypogonadism (HP:0000815)1.75271201
86Hyperglycinemia (HP:0002154)1.75237702
87Pallor (HP:0000980)1.71532871
88Secondary amenorrhea (HP:0000869)1.70350295
89Premature ovarian failure (HP:0008209)1.70204098
90Severe visual impairment (HP:0001141)1.69745879
91Blindness (HP:0000618)1.69036545
92Sparse eyelashes (HP:0000653)1.69015672
93Glycosuria (HP:0003076)1.67106398
94Abnormality of urine glucose concentration (HP:0011016)1.67106398
95Hypokinesia (HP:0002375)1.66747279
96Postnatal microcephaly (HP:0005484)1.65804295
97Gliosis (HP:0002171)1.63711198
98Hypoplasia of the uterus (HP:0000013)1.63317574
99Progressive microcephaly (HP:0000253)1.61461953
100Death in infancy (HP:0001522)1.60817809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.11126462
2BUB13.75228174
3VRK23.73743973
4TESK23.33132454
5SRPK13.18555730
6BCKDK3.08753947
7NEK12.66542560
8PBK2.66125332
9CDC72.65533571
10PIM22.43338876
11ARAF2.30068893
12NME12.13639951
13ZAK2.11864113
14LIMK12.09324090
15MST42.06695053
16TESK12.06278255
17EIF2AK12.00373385
18STK161.95645458
19VRK11.94214198
20MAP4K21.91382152
21EIF2AK31.83714101
22PDK21.82103957
23TRIM281.73654127
24KDR1.70393550
25AURKA1.54296860
26SCYL21.35911402
27PLK11.35832695
28CSNK1G31.33353787
29TTK1.31452706
30BRSK11.30703829
31NUAK11.29221344
32TSSK61.25093747
33IRAK31.22189676
34CSNK1G11.14178360
35ATR1.08023773
36WEE11.06947675
37AURKB1.06361288
38DAPK11.05809308
39CDK191.05626980
40ACVR1B1.04639857
41PLK41.02703703
42PLK31.02109736
43RPS6KA51.01598365
44TLK10.98903736
45ABL20.97372456
46CSNK1A1L0.93160535
47CDK80.92982531
48BRAF0.87137109
49DYRK20.86225363
50WNK30.83195607
51MAP2K70.82717814
52BRSK20.82673781
53CSNK2A10.78584811
54CSNK1G20.78080636
55CDK70.78048917
56CHEK20.76944620
57MAP3K110.76454859
58PRKCI0.75499341
59RAF10.74648722
60ILK0.74096747
61MAP3K120.73251655
62CCNB10.72198874
63RPS6KA40.71341654
64CSNK2A20.69319686
65DYRK30.69249062
66TAOK30.68607355
67PAK10.67389978
68MAPKAPK30.66813224
69CHEK10.66279843
70FLT30.57003103
71EPHA20.54422548
72DAPK30.52875173
73PIM10.52309357
74STK40.47309406
75AKT20.46332851
76LRRK20.43490914
77CAMK2G0.42294912
78TAOK20.40934670
79ERBB30.40526205
80ATM0.40519197
81CLK10.37998648
82RPS6KB20.37097595
83EIF2AK20.36415212
84PAK40.35509991
85MKNK10.34267896
86GRK70.32121607
87WNK40.31283297
88CSNK1A10.30001331
89BMPR1B0.29299218
90MAP3K80.28864082
91TXK0.28691140
92CDK20.28245947
93ADRBK20.25225546
94MAP3K50.23759289
95CDK140.23657380
96ERBB40.22717277
97CDK10.22602332
98IKBKB0.22221541
99PINK10.22100056
100STK390.21283017

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.30243359
2Oxidative phosphorylation_Homo sapiens_hsa001903.54145054
3Ribosome_Homo sapiens_hsa030103.53963343
4DNA replication_Homo sapiens_hsa030303.40059950
5Parkinsons disease_Homo sapiens_hsa050123.13725993
6RNA polymerase_Homo sapiens_hsa030203.11151365
7Mismatch repair_Homo sapiens_hsa034302.94641653
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88091605
9Protein export_Homo sapiens_hsa030602.54637822
10Base excision repair_Homo sapiens_hsa034102.44334807
11Homologous recombination_Homo sapiens_hsa034402.37799339
12Huntingtons disease_Homo sapiens_hsa050162.23165559
13Sulfur relay system_Homo sapiens_hsa041222.22134032
14Pyrimidine metabolism_Homo sapiens_hsa002402.14512334
15Spliceosome_Homo sapiens_hsa030402.11425700
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97169578
17Fatty acid elongation_Homo sapiens_hsa000621.96904704
18Alzheimers disease_Homo sapiens_hsa050101.89318164
19Nucleotide excision repair_Homo sapiens_hsa034201.88415874
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80421829
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.72966574
22Fanconi anemia pathway_Homo sapiens_hsa034601.69445452
23RNA transport_Homo sapiens_hsa030131.68295158
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.66925481
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63992492
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62299489
27Basal transcription factors_Homo sapiens_hsa030221.48153488
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46478909
29RNA degradation_Homo sapiens_hsa030181.42358406
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42078431
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.40459934
32Folate biosynthesis_Homo sapiens_hsa007901.37301392
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36847204
34Pyruvate metabolism_Homo sapiens_hsa006201.31503065
35Purine metabolism_Homo sapiens_hsa002301.29542204
36Sulfur metabolism_Homo sapiens_hsa009201.24367595
37One carbon pool by folate_Homo sapiens_hsa006701.23788890
38Non-homologous end-joining_Homo sapiens_hsa034501.11395828
39Selenocompound metabolism_Homo sapiens_hsa004501.10599618
40Cell cycle_Homo sapiens_hsa041101.08751703
41Biosynthesis of amino acids_Homo sapiens_hsa012301.07492659
42Cardiac muscle contraction_Homo sapiens_hsa042601.07233958
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03741655
44Propanoate metabolism_Homo sapiens_hsa006401.02894288
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01080665
46Steroid biosynthesis_Homo sapiens_hsa001001.00594444
47Carbon metabolism_Homo sapiens_hsa012000.98463743
48Glutathione metabolism_Homo sapiens_hsa004800.94507266
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93154077
50Vitamin B6 metabolism_Homo sapiens_hsa007500.93044552
51Collecting duct acid secretion_Homo sapiens_hsa049660.88925083
52Metabolic pathways_Homo sapiens_hsa011000.82316693
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78915591
54Regulation of autophagy_Homo sapiens_hsa041400.78002116
55mRNA surveillance pathway_Homo sapiens_hsa030150.76385442
56Vibrio cholerae infection_Homo sapiens_hsa051100.75786588
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72779815
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72481432
59Fructose and mannose metabolism_Homo sapiens_hsa000510.69293523
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67220385
61N-Glycan biosynthesis_Homo sapiens_hsa005100.65811660
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64546250
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63649203
64Peroxisome_Homo sapiens_hsa041460.61683783
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61201262
66p53 signaling pathway_Homo sapiens_hsa041150.60494420
67Pentose phosphate pathway_Homo sapiens_hsa000300.53368575
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.53279999
69Systemic lupus erythematosus_Homo sapiens_hsa053220.51314265
70Arginine and proline metabolism_Homo sapiens_hsa003300.49173074
71Epstein-Barr virus infection_Homo sapiens_hsa051690.46749351
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46604269
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43567930
74Primary immunodeficiency_Homo sapiens_hsa053400.42987063
75Butanoate metabolism_Homo sapiens_hsa006500.41568641
76Galactose metabolism_Homo sapiens_hsa000520.39698474
77Fatty acid metabolism_Homo sapiens_hsa012120.39378462
78Tryptophan metabolism_Homo sapiens_hsa003800.39251419
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37325389
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36796457
81Oocyte meiosis_Homo sapiens_hsa041140.34312374
82Legionellosis_Homo sapiens_hsa051340.32066246
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31634341
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31229711
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30616076
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.29220622
87Alcoholism_Homo sapiens_hsa050340.23645585
88Tyrosine metabolism_Homo sapiens_hsa003500.21192627
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19277583
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18733320
91Shigellosis_Homo sapiens_hsa051310.17571195
92Rheumatoid arthritis_Homo sapiens_hsa053230.16998241
93beta-Alanine metabolism_Homo sapiens_hsa004100.13886345
94Phototransduction_Homo sapiens_hsa047440.12633597
95Synaptic vesicle cycle_Homo sapiens_hsa047210.09439651
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09180848
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08476057
98Phenylalanine metabolism_Homo sapiens_hsa003600.07564606
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.06119532
100Chemical carcinogenesis_Homo sapiens_hsa052040.05829664

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