ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.77156621
2	response to pheromone (GO:0019236)	4.54871615
3	piRNA metabolic process (GO:0034587)	4.50925869
4	DNA deamination (GO:0045006)	4.37049832
5	male meiosis I (GO:0007141)	4.36295463
6	protein complex biogenesis (GO:0070271)	4.11073073
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.06758507
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.06758507
9	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.01350095
10	NADH dehydrogenase complex assembly (GO:0010257)	4.01350095
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.01350095
12	mitochondrial respiratory chain complex assembly (GO:0033108)	3.87361155
13	preassembly of GPI anchor in ER membrane (GO:0016254)	3.85967489
14	synapsis (GO:0007129)	3.82760139
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.77479053
16	ATP synthesis coupled proton transport (GO:0015986)	3.77479053
17	male meiosis (GO:0007140)	3.74576650
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.70933004
19	DNA methylation involved in gamete generation (GO:0043046)	3.59755755
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.59232741
21	meiosis I (GO:0007127)	3.57692122
22	respiratory chain complex IV assembly (GO:0008535)	3.54109641
23	platelet dense granule organization (GO:0060155)	3.51585666
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.36752378
25	regulation of cilium movement (GO:0003352)	3.34872596
26	protein-cofactor linkage (GO:0018065)	3.31908086
27	proteasome assembly (GO:0043248)	3.31484944
28	cytochrome complex assembly (GO:0017004)	3.30704243
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.27779369
30	detection of light stimulus involved in visual perception (GO:0050908)	3.27779369
31	protein neddylation (GO:0045116)	3.21097920
32	protein polyglutamylation (GO:0018095)	3.17708027
33	mannosylation (GO:0097502)	3.17524151
34	epithelial cilium movement (GO:0003351)	3.16762407
35	chaperone-mediated protein transport (GO:0072321)	3.15128154
36	nonmotile primary cilium assembly (GO:0035058)	3.06929207
37	ubiquinone biosynthetic process (GO:0006744)	3.05402894
38	L-fucose catabolic process (GO:0042355)	3.04851068
39	fucose catabolic process (GO:0019317)	3.04851068
40	L-fucose metabolic process (GO:0042354)	3.04851068
41	indolalkylamine metabolic process (GO:0006586)	3.04384093
42	replication fork processing (GO:0031297)	3.03487384
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03292115
44	reciprocal DNA recombination (GO:0035825)	3.03060573
45	reciprocal meiotic recombination (GO:0007131)	3.03060573
46	water-soluble vitamin biosynthetic process (GO:0042364)	3.00913187
47	kynurenine metabolic process (GO:0070189)	3.00134398
48	indole-containing compound catabolic process (GO:0042436)	2.98538496
49	indolalkylamine catabolic process (GO:0046218)	2.98538496
50	tryptophan catabolic process (GO:0006569)	2.98538496
51	negative regulation of telomere maintenance (GO:0032205)	2.97473067
52	resolution of meiotic recombination intermediates (GO:0000712)	2.95594704
53	electron transport chain (GO:0022900)	2.95549930
54	peptidyl-histidine modification (GO:0018202)	2.94079046
55	sperm motility (GO:0030317)	2.92412487
56	protein K6-linked ubiquitination (GO:0085020)	2.90871236
57	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.90436035
58	cellular ketone body metabolic process (GO:0046950)	2.89428031
59	respiratory electron transport chain (GO:0022904)	2.88876964
60	cornea development in camera-type eye (GO:0061303)	2.88555121
61	axoneme assembly (GO:0035082)	2.84417062
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.83340130
63	ubiquinone metabolic process (GO:0006743)	2.82562188
64	iron-sulfur cluster assembly (GO:0016226)	2.80137477
65	metallo-sulfur cluster assembly (GO:0031163)	2.80137477
66	chromosome organization involved in meiosis (GO:0070192)	2.75751831
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.75608435
68	GPI anchor metabolic process (GO:0006505)	2.72078546
69	meiotic nuclear division (GO:0007126)	2.71182616
70	multicellular organism reproduction (GO:0032504)	2.68754043
71	intraciliary transport (GO:0042073)	2.66382022
72	ketone body metabolic process (GO:1902224)	2.66102062
73	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.65825293
74	ATP biosynthetic process (GO:0006754)	2.65819424
75	dopamine transport (GO:0015872)	2.65000047
76	regulation of meiosis I (GO:0060631)	2.62821981
77	tRNA processing (GO:0008033)	2.62229577
78	protein localization to cilium (GO:0061512)	2.59705656
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.59133991
80	oxidative phosphorylation (GO:0006119)	2.57952387
81	rRNA modification (GO:0000154)	2.57606672
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.57067589
83	tryptophan metabolic process (GO:0006568)	2.56969297
84	regulation of microtubule-based movement (GO:0060632)	2.55508710
85	behavioral response to ethanol (GO:0048149)	2.54154207
86	pseudouridine synthesis (GO:0001522)	2.54101887
87	intracellular protein transmembrane import (GO:0044743)	2.53942377
88	cilium morphogenesis (GO:0060271)	2.53780963
89	meiotic chromosome segregation (GO:0045132)	2.53653166
90	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.53521249
91	amino acid salvage (GO:0043102)	2.53043536
92	L-methionine salvage (GO:0071267)	2.53043536
93	L-methionine biosynthetic process (GO:0071265)	2.53043536
94	C-terminal protein lipidation (GO:0006501)	2.51613429
95	positive regulation of mitochondrial fission (GO:0090141)	2.51411580
96	C-terminal protein amino acid modification (GO:0018410)	2.51032577
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.49695335
98	termination of RNA polymerase III transcription (GO:0006386)	2.48755954
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48755954
100	neuronal action potential (GO:0019228)	2.48423371

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.87968541
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.05265278
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.00949229
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.99545609
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.99132897
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98055543
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74758858
8	VDR_22108803_ChIP-Seq_LS180_Human	2.72387262
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.70786591
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35844557
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.20860592
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.19575123
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.12449015
14	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.10034374
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.03608053
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.03019362
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.00276088
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.95526116
19	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92287611
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91704636
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.91068771
22	EWS_26573619_Chip-Seq_HEK293_Human	1.89907178
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.86276028
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.85440240
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.83225334
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79660832
27	FUS_26573619_Chip-Seq_HEK293_Human	1.77696206
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.74803603
29	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71121761
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.69819370
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63273510
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.58193580
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.57224710
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54620637
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.53956421
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.51835999
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50700456
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.50172623
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.49928910
40	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.46555247
41	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.46491589
42	P300_19829295_ChIP-Seq_ESCs_Human	1.45270510
43	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42826340
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38627488
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34391477
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.33235300
47	ERA_21632823_ChIP-Seq_H3396_Human	1.31699833
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31112927
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31112927
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29780787
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29780787
52	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25766676
53	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24818589
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.24694804
55	NCOR_22424771_ChIP-Seq_293T_Human	1.23629454
56	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23182972
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.21848101
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21848101
59	AR_20517297_ChIP-Seq_VCAP_Human	1.21315784
60	GABP_19822575_ChIP-Seq_HepG2_Human	1.19380384
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15843658
62	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14916637
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14737276
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14291950
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13833171
66	MYC_19829295_ChIP-Seq_ESCs_Human	1.12007095
67	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.10570184
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10483797
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10346216
70	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.09890584
71	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.09717572
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07592917
73	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.07591683
74	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.07558628
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06694501
76	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.06028321
77	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05424961
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.04852883
79	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.02829315
80	BCAT_22108803_ChIP-Seq_LS180_Human	1.02717337
81	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02584867
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02177178
83	STAT3_23295773_ChIP-Seq_U87_Human	1.00337433
84	AR_25329375_ChIP-Seq_VCAP_Human	0.98035764
85	OCT4_20526341_ChIP-Seq_ESCs_Human	0.97284537
86	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.96225118
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.94772075
88	TCF4_23295773_ChIP-Seq_U87_Human	0.94249077
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94083947
90	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93151462
91	HTT_18923047_ChIP-ChIP_STHdh_Human	0.92754785
92	RAC3_21632823_ChIP-Seq_H3396_Human	0.92488359
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92161652
94	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91991312
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.91350465
96	DCP1A_22483619_ChIP-Seq_HELA_Human	0.90915940
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.90464239
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90403276
99	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.90299466
100	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.89926536

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.29680848
2	MP0002102_abnormal_ear_morphology	2.61678361
3	MP0002163_abnormal_gland_morphology	2.42967258
4	MP0003195_calcinosis	2.42113366
5	MP0005551_abnormal_eye_electrophysiolog	2.39246272
6	MP0001968_abnormal_touch/_nociception	2.31114973
7	MP0003136_yellow_coat_color	2.20477981
8	MP0003646_muscle_fatigue	2.19528053
9	MP0002876_abnormal_thyroid_physiology	2.15144757
10	MP0000372_irregular_coat_pigmentation	2.11583694
11	MP0003011_delayed_dark_adaptation	2.09657985
12	MP0006292_abnormal_olfactory_placode	2.09064481
13	MP0004147_increased_porphyrin_level	2.08847146
14	MP0008058_abnormal_DNA_repair	2.08751405
15	MP0005646_abnormal_pituitary_gland	2.04427192
16	MP0002736_abnormal_nociception_after	2.01488837
17	MP0001529_abnormal_vocalization	2.00244513
18	MP0001986_abnormal_taste_sensitivity	1.98626346
19	MP0005645_abnormal_hypothalamus_physiol	1.91234798
20	MP0002837_dystrophic_cardiac_calcinosis	1.87369276
21	MP0006072_abnormal_retinal_apoptosis	1.86450539
22	MP0008875_abnormal_xenobiotic_pharmacok	1.82932543
23	MP0008872_abnormal_physiological_respon	1.82077318
24	MP0002653_abnormal_ependyma_morphology	1.75858052
25	MP0009046_muscle_twitch	1.75683304
26	MP0001984_abnormal_olfaction	1.68800521
27	MP0002160_abnormal_reproductive_system	1.68771636
28	MP0009745_abnormal_behavioral_response	1.66706451
29	MP0002234_abnormal_pharynx_morphology	1.66105675
30	MP0008995_early_reproductive_senescence	1.65608882
31	MP0002638_abnormal_pupillary_reflex	1.63645239
32	MP0008789_abnormal_olfactory_epithelium	1.60571546
33	MP0005253_abnormal_eye_physiology	1.59995230
34	MP0005379_endocrine/exocrine_gland_phen	1.58297747
35	MP0000631_abnormal_neuroendocrine_gland	1.55417193
36	MP0005410_abnormal_fertilization	1.49765477
37	MP0004142_abnormal_muscle_tone	1.47456433
38	MP0002272_abnormal_nervous_system	1.47405627
39	MP0002210_abnormal_sex_determination	1.46977010
40	MP0005389_reproductive_system_phenotype	1.45464623
41	MP0003880_abnormal_central_pattern	1.45330438
42	MP0003698_abnormal_male_reproductive	1.43097848
43	MP0001929_abnormal_gametogenesis	1.41464407
44	MP0002938_white_spotting	1.41344834
45	MP0003786_premature_aging	1.30437347
46	MP0004043_abnormal_pH_regulation	1.28823755
47	MP0003718_maternal_effect	1.25432893
48	MP0006276_abnormal_autonomic_nervous	1.23881632
49	MP0010386_abnormal_urinary_bladder	1.21530296
50	MP0003787_abnormal_imprinting	1.21454248
51	MP0005174_abnormal_tail_pigmentation	1.17804675
52	MP0006036_abnormal_mitochondrial_physio	1.17591942
53	MP0004885_abnormal_endolymph	1.16076580
54	MP0001919_abnormal_reproductive_system	1.15160940
55	MP0000653_abnormal_sex_gland	1.14267362
56	MP0005394_taste/olfaction_phenotype	1.14221025
57	MP0005499_abnormal_olfactory_system	1.14221025
58	MP0001145_abnormal_male_reproductive	1.14198487
59	MP0001764_abnormal_homeostasis	1.11646770
60	MP0001501_abnormal_sleep_pattern	1.11572935
61	MP0005084_abnormal_gallbladder_morpholo	1.11410216
62	MP0002557_abnormal_social/conspecific_i	1.10567392
63	MP0004145_abnormal_muscle_electrophysio	1.09787491
64	MP0000049_abnormal_middle_ear	1.09721795
65	MP0002095_abnormal_skin_pigmentation	1.09268162
66	MP0001905_abnormal_dopamine_level	1.08321388
67	MP0000427_abnormal_hair_cycle	1.06816673
68	MP0003283_abnormal_digestive_organ	1.06247422
69	MP0004133_heterotaxia	1.05582666
70	MP0001970_abnormal_pain_threshold	1.02945166
71	MP0002064_seizures	1.02382765
72	MP0002572_abnormal_emotion/affect_behav	1.01425829
73	MP0004924_abnormal_behavior	1.01213868
74	MP0005386_behavior/neurological_phenoty	1.01213868
75	MP0003806_abnormal_nucleotide_metabolis	0.99069524
76	MP0002733_abnormal_thermal_nociception	0.99026181
77	MP0006035_abnormal_mitochondrial_morpho	0.96894448
78	MP0001486_abnormal_startle_reflex	0.96315491
79	MP0002735_abnormal_chemical_nociception	0.96026987
80	MP0005670_abnormal_white_adipose	0.95374459
81	MP0005423_abnormal_somatic_nervous	0.94489400
82	MP0005075_abnormal_melanosome_morpholog	0.94228996
83	MP0003186_abnormal_redox_activity	0.92151540
84	MP0000569_abnormal_digit_pigmentation	0.90172617
85	MP0005332_abnormal_amino_acid	0.89131569
86	MP0001293_anophthalmia	0.87673696
87	MP0005195_abnormal_posterior_eye	0.87439217
88	MP0002751_abnormal_autonomic_nervous	0.87011479
89	MP0003119_abnormal_digestive_system	0.85419420
90	MP0001485_abnormal_pinna_reflex	0.83304881
91	MP0001119_abnormal_female_reproductive	0.82940815
92	MP0003121_genomic_imprinting	0.82453451
93	MP0002752_abnormal_somatic_nervous	0.82276854
94	MP0001502_abnormal_circadian_rhythm	0.81710157
95	MP0002067_abnormal_sensory_capabilities	0.81314964
96	MP0001324_abnormal_eye_pigmentation	0.81222031
97	MP0000015_abnormal_ear_pigmentation	0.80928948
98	MP0003122_maternal_imprinting	0.76731588
99	MP0005083_abnormal_biliary_tract	0.76639180
100	MP0002822_catalepsy	0.76179123

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.01188953
2	Abnormality of midbrain morphology (HP:0002418)	3.78894501
3	Molar tooth sign on MRI (HP:0002419)	3.78894501
4	Pancreatic fibrosis (HP:0100732)	3.75461658
5	True hermaphroditism (HP:0010459)	3.49341421
6	Congenital stationary night blindness (HP:0007642)	3.40753615
7	Nephronophthisis (HP:0000090)	3.32506084
8	Acute necrotizing encephalopathy (HP:0006965)	3.31397774
9	Type II lissencephaly (HP:0007260)	3.29256466
10	Mitochondrial inheritance (HP:0001427)	3.20876261
11	Lipid accumulation in hepatocytes (HP:0006561)	3.07497165
12	Abnormality of the renal cortex (HP:0011035)	3.07284646
13	Acute encephalopathy (HP:0006846)	3.03364342
14	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99994572
15	Medial flaring of the eyebrow (HP:0010747)	2.98521879
16	Increased CSF lactate (HP:0002490)	2.91787768
17	Hepatocellular necrosis (HP:0001404)	2.90511800
18	Hepatic necrosis (HP:0002605)	2.89932969
19	Abnormality of the renal medulla (HP:0100957)	2.88641051
20	Attenuation of retinal blood vessels (HP:0007843)	2.81246542
21	Progressive macrocephaly (HP:0004481)	2.73352746
22	3-Methylglutaconic aciduria (HP:0003535)	2.65428611
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.61033292
24	Cystic liver disease (HP:0006706)	2.55118822
25	Tubular atrophy (HP:0000092)	2.54521443
26	Renal cortical cysts (HP:0000803)	2.53628873
27	Pendular nystagmus (HP:0012043)	2.52929445
28	Sclerocornea (HP:0000647)	2.49420091
29	Inability to walk (HP:0002540)	2.44027036
30	Abnormal drinking behavior (HP:0030082)	2.39939764
31	Polydipsia (HP:0001959)	2.39939764
32	Increased hepatocellular lipid droplets (HP:0006565)	2.39524086
33	Concave nail (HP:0001598)	2.38659732
34	Gait imbalance (HP:0002141)	2.34054035
35	Congenital primary aphakia (HP:0007707)	2.33436917
36	Nephrogenic diabetes insipidus (HP:0009806)	2.31492536
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.30998414
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.30998414
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.29754736
40	Lissencephaly (HP:0001339)	2.28495063
41	Optic disc pallor (HP:0000543)	2.27965630
42	Cerebellar dysplasia (HP:0007033)	2.26856895
43	Anencephaly (HP:0002323)	2.22880364
44	Increased corneal curvature (HP:0100692)	2.22409665
45	Keratoconus (HP:0000563)	2.22409665
46	Hyperventilation (HP:0002883)	2.16347402
47	Postaxial foot polydactyly (HP:0001830)	2.15598838
48	Absent thumb (HP:0009777)	2.15316855
49	Colon cancer (HP:0003003)	2.14897063
50	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14880402
51	Increased serum lactate (HP:0002151)	2.14691817
52	Tubulointerstitial nephritis (HP:0001970)	2.12928758
53	Broad-based gait (HP:0002136)	2.12580190
54	Lactic acidosis (HP:0003128)	2.09738468
55	Decreased central vision (HP:0007663)	2.08887148
56	Thyroid-stimulating hormone excess (HP:0002925)	2.08260494
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.06074428
58	Abolished electroretinogram (ERG) (HP:0000550)	2.03583393
59	Methylmalonic aciduria (HP:0012120)	2.03433985
60	Abnormality of alanine metabolism (HP:0010916)	2.01834092
61	Hyperalaninemia (HP:0003348)	2.01834092
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.01834092
63	Methylmalonic acidemia (HP:0002912)	2.01585361
64	Cerebral edema (HP:0002181)	2.00347950
65	Bile duct proliferation (HP:0001408)	1.99678522
66	Abnormal biliary tract physiology (HP:0012439)	1.99678522
67	Polyuria (HP:0000103)	1.98428984
68	Hypoplasia of the pons (HP:0012110)	1.97549510
69	Hypoplasia of the fovea (HP:0007750)	1.97446092
70	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.97446092
71	Absent/shortened dynein arms (HP:0200106)	1.97260116
72	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.97260116
73	Congenital hepatic fibrosis (HP:0002612)	1.96894599
74	Patellar aplasia (HP:0006443)	1.96048334
75	Aplasia/Hypoplasia of the patella (HP:0006498)	1.95613755
76	Male pseudohermaphroditism (HP:0000037)	1.94845827
77	Abnormality of the ileum (HP:0001549)	1.94519752
78	Progressive inability to walk (HP:0002505)	1.93655917
79	Severe muscular hypotonia (HP:0006829)	1.93626286
80	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93402497
81	Retinal dysplasia (HP:0007973)	1.93023849
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92792613
83	Renal Fanconi syndrome (HP:0001994)	1.88183391
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.87921844
85	Abnormal number of erythroid precursors (HP:0012131)	1.87366170
86	Occipital encephalocele (HP:0002085)	1.86510903
87	Meckel diverticulum (HP:0002245)	1.86442820
88	Abnormality of the pons (HP:0007361)	1.84606473
89	Chronic hepatic failure (HP:0100626)	1.83811128
90	Increased muscle lipid content (HP:0009058)	1.83082226
91	Congenital, generalized hypertrichosis (HP:0004540)	1.82060232
92	Pachygyria (HP:0001302)	1.81769692
93	Generalized aminoaciduria (HP:0002909)	1.79093472
94	Abnormal respiratory epithelium morphology (HP:0012253)	1.78955156
95	Abnormal respiratory motile cilium morphology (HP:0005938)	1.78955156
96	Hyperglycinemia (HP:0002154)	1.78651024
97	Genital tract atresia (HP:0001827)	1.78588543
98	Short tibia (HP:0005736)	1.78088451
99	Hypothermia (HP:0002045)	1.77271467
100	Abnormality of the labia minora (HP:0012880)	1.76911232

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.67032132
2	FRK	3.55635499
3	ADRBK2	3.41670836
4	MAP4K2	3.32066688
5	WNK4	3.15489895
6	BMPR1B	2.77117007
7	NUAK1	2.54666643
8	PINK1	2.50475910
9	TLK1	2.39547046
10	WNK3	2.22734988
11	GRK1	2.13805153
12	TAOK3	2.07950004
13	VRK2	2.02577850
14	BCKDK	1.92861499
15	MAP3K4	1.81072971
16	STK39	1.76606535
17	MAPK13	1.70733212
18	TXK	1.69701445
19	INSRR	1.64525471
20	VRK1	1.64246989
21	DYRK2	1.48038863
22	OXSR1	1.34877887
23	CSNK1G3	1.34257279
24	DAPK2	1.32050243
25	MAP2K7	1.31638998
26	ACVR1B	1.29022108
27	TRIM28	1.23869323
28	ADRBK1	1.22017787
29	CASK	1.17325072
30	CCNB1	1.17051177
31	CSNK1G2	1.16174165
32	CSNK1A1L	1.05746750
33	CSNK1G1	1.05628719
34	NEK2	1.04861347
35	GRK7	1.01595674
36	CAMKK2	0.99196950
37	PLK4	0.99022075
38	PLK2	0.98738262
39	STK16	0.96037841
40	PRKCG	0.88333567
41	LIMK1	0.88114251
42	RPS6KA5	0.86522227
43	PLK3	0.84162425
44	BUB1	0.83396829
45	BCR	0.83180254
46	DYRK3	0.83034479
47	PHKG2	0.81284126
48	PHKG1	0.81284126
49	PLK1	0.81212822
50	GRK5	0.79950640
51	CDK19	0.78635306
52	TIE1	0.78394407
53	MARK3	0.77223417
54	MAP2K2	0.76920598
55	TGFBR1	0.74220337
56	MAP2K6	0.68485101
57	PRKCE	0.66408242
58	PDK2	0.63116187
59	MKNK2	0.62647479
60	IKBKB	0.62400539
61	EIF2AK3	0.61331904
62	NEK1	0.61265182
63	SIK2	0.61000968
64	MAPKAPK5	0.59544360
65	ATR	0.58940559
66	MST4	0.58362038
67	CHEK2	0.58123808
68	TAF1	0.57385003
69	PIK3CA	0.56522634
70	PRKCQ	0.56173270
71	STK38L	0.55789523
72	PAK3	0.54843782
73	PRKCI	0.54627214
74	KDR	0.52188754
75	EPHA4	0.51079474
76	NME1	0.49724858
77	MUSK	0.48647498
78	MAPKAPK3	0.46963280
79	MAPK15	0.46536714
80	AURKA	0.45312087
81	PRKACA	0.45134026
82	CAMK2A	0.44306399
83	PTK2B	0.43446937
84	MAP2K4	0.42532702
85	CDK8	0.42067902
86	CAMK1	0.41537484
87	SRPK1	0.41313373
88	CSNK1A1	0.40987558
89	TNIK	0.40671238
90	MARK1	0.40438167
91	DAPK1	0.38695647
92	BRSK2	0.38262873
93	STK11	0.36069994
94	PIM2	0.35846198
95	TEC	0.35478528
96	KIT	0.34952866
97	CSNK2A1	0.34556382
98	ATM	0.34271624
99	EIF2AK1	0.33463448
100	PRKCA	0.33452184

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23402923
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.81859231
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.73811213
4	Parkinsons disease_Homo sapiens_hsa05012	2.73030361
5	Homologous recombination_Homo sapiens_hsa03440	2.50470338
6	Phototransduction_Homo sapiens_hsa04744	2.37152343
7	RNA polymerase_Homo sapiens_hsa03020	2.17542095
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15855039
9	Sulfur relay system_Homo sapiens_hsa04122	2.08758661
10	Ribosome_Homo sapiens_hsa03010	2.03954416
11	Protein export_Homo sapiens_hsa03060	1.92931438
12	Huntingtons disease_Homo sapiens_hsa05016	1.90332273
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.83766838
14	Proteasome_Homo sapiens_hsa03050	1.82382885
15	Butanoate metabolism_Homo sapiens_hsa00650	1.75436961
16	Alzheimers disease_Homo sapiens_hsa05010	1.68605388
17	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.66274283
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66231098
19	Nicotine addiction_Homo sapiens_hsa05033	1.65883217
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62640752
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.60699677
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.60508146
23	Basal transcription factors_Homo sapiens_hsa03022	1.59035695
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.57427012
25	One carbon pool by folate_Homo sapiens_hsa00670	1.53648543
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.53084385
27	Propanoate metabolism_Homo sapiens_hsa00640	1.46323692
28	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45784437
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40336487
30	Mismatch repair_Homo sapiens_hsa03430	1.35724324
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.35714241
32	RNA degradation_Homo sapiens_hsa03018	1.31275712
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.30233779
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.30167180
35	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29686067
36	Caffeine metabolism_Homo sapiens_hsa00232	1.26212862
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.25491594
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25382775
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24673184
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.19770843
41	Purine metabolism_Homo sapiens_hsa00230	1.18282946
42	Base excision repair_Homo sapiens_hsa03410	1.14597080
43	Peroxisome_Homo sapiens_hsa04146	1.13412461
44	Olfactory transduction_Homo sapiens_hsa04740	1.12536505
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.09865593
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01453485
47	Regulation of autophagy_Homo sapiens_hsa04140	1.01065619
48	Morphine addiction_Homo sapiens_hsa05032	0.98224250
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97060453
50	Sulfur metabolism_Homo sapiens_hsa00920	0.96874745
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94765015
52	Nucleotide excision repair_Homo sapiens_hsa03420	0.94405100
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.93539891
54	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.93348864
55	DNA replication_Homo sapiens_hsa03030	0.93217016
56	Taste transduction_Homo sapiens_hsa04742	0.91717651
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.91284148
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.90219892
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85906170
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.85394393
61	Retinol metabolism_Homo sapiens_hsa00830	0.85253226
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.85244010
63	Metabolic pathways_Homo sapiens_hsa01100	0.85198115
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.85120038
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81794732
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81119419
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79888184
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78684982
69	Fatty acid elongation_Homo sapiens_hsa00062	0.77158545
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.75249217
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.72285829
72	GABAergic synapse_Homo sapiens_hsa04727	0.71785912
73	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.69553391
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.69358327
75	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.67856818
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65130081
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65105919
78	Steroid biosynthesis_Homo sapiens_hsa00100	0.64839634
79	RNA transport_Homo sapiens_hsa03013	0.61587250
80	Circadian entrainment_Homo sapiens_hsa04713	0.60233723
81	Folate biosynthesis_Homo sapiens_hsa00790	0.59847992
82	Serotonergic synapse_Homo sapiens_hsa04726	0.56457170
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.55530018
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.54708455
85	ABC transporters_Homo sapiens_hsa02010	0.52020838
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51864434
87	Fatty acid degradation_Homo sapiens_hsa00071	0.48083657
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.47263012
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.46203969
90	Insulin secretion_Homo sapiens_hsa04911	0.45463982
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.43064785
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42181629
93	Calcium signaling pathway_Homo sapiens_hsa04020	0.41185617
94	Glutathione metabolism_Homo sapiens_hsa00480	0.39125852
95	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38878713
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.38651444
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.37394430
98	Asthma_Homo sapiens_hsa05310	0.36886765
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35890506
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.33327936

C16ORF95

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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