ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.23807486
2	response to pheromone (GO:0019236)	4.75457506
3	fucose catabolic process (GO:0019317)	4.53882239
4	L-fucose metabolic process (GO:0042354)	4.53882239
5	L-fucose catabolic process (GO:0042355)	4.53882239
6	cellular ketone body metabolic process (GO:0046950)	4.00405575
7	indolalkylamine metabolic process (GO:0006586)	3.88914668
8	tryptophan catabolic process (GO:0006569)	3.81543430
9	indole-containing compound catabolic process (GO:0042436)	3.81543430
10	indolalkylamine catabolic process (GO:0046218)	3.81543430
11	kynurenine metabolic process (GO:0070189)	3.76042496
12	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.73128801
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.72350461
14	protein polyglutamylation (GO:0018095)	3.66223931
15	DNA deamination (GO:0045006)	3.64158378
16	piRNA metabolic process (GO:0034587)	3.61819861
17	sperm motility (GO:0030317)	3.60037967
18	ketone body metabolic process (GO:1902224)	3.58083309
19	detection of light stimulus involved in visual perception (GO:0050908)	3.53967453
20	detection of light stimulus involved in sensory perception (GO:0050962)	3.53967453
21	regulation of cilium movement (GO:0003352)	3.44409067
22	platelet dense granule organization (GO:0060155)	3.42545715
23	epithelial cilium movement (GO:0003351)	3.41819682
24	negative regulation of telomere maintenance (GO:0032205)	3.38069375
25	tryptophan metabolic process (GO:0006568)	3.32840243
26	multicellular organism reproduction (GO:0032504)	3.30689067
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.26250739
28	nonmotile primary cilium assembly (GO:0035058)	3.10828014
29	axoneme assembly (GO:0035082)	3.10197594
30	negative regulation of mast cell activation (GO:0033004)	3.07531618
31	indole-containing compound metabolic process (GO:0042430)	3.05732331
32	respiratory chain complex IV assembly (GO:0008535)	2.95000082
33	amine catabolic process (GO:0009310)	2.94043236
34	cellular biogenic amine catabolic process (GO:0042402)	2.94043236
35	primary amino compound metabolic process (GO:1901160)	2.93809823
36	behavioral response to ethanol (GO:0048149)	2.93740162
37	gamma-aminobutyric acid transport (GO:0015812)	2.92843388
38	protein complex biogenesis (GO:0070271)	2.91854450
39	neuronal action potential (GO:0019228)	2.89810397
40	kidney morphogenesis (GO:0060993)	2.88415728
41	retinal cone cell development (GO:0046549)	2.87739284
42	reflex (GO:0060004)	2.83792176
43	protein localization to cilium (GO:0061512)	2.82597870
44	cilium organization (GO:0044782)	2.82220460
45	DNA methylation involved in gamete generation (GO:0043046)	2.82027080
46	rhodopsin mediated signaling pathway (GO:0016056)	2.79488109
47	preassembly of GPI anchor in ER membrane (GO:0016254)	2.79303336
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.78654691
49	NADH dehydrogenase complex assembly (GO:0010257)	2.78654691
50	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.78654691
51	cilium morphogenesis (GO:0060271)	2.77122498
52	sulfation (GO:0051923)	2.76744751
53	auditory receptor cell stereocilium organization (GO:0060088)	2.76370055
54	cilium or flagellum-dependent cell motility (GO:0001539)	2.76340710
55	cilium movement (GO:0003341)	2.76194753
56	centriole replication (GO:0007099)	2.75930816
57	reciprocal meiotic recombination (GO:0007131)	2.75224656
58	reciprocal DNA recombination (GO:0035825)	2.75224656
59	cilium assembly (GO:0042384)	2.75152089
60	protein-cofactor linkage (GO:0018065)	2.74892969
61	regulation of action potential (GO:0098900)	2.74180664
62	rRNA catabolic process (GO:0016075)	2.72204922
63	cornea development in camera-type eye (GO:0061303)	2.71180344
64	photoreceptor cell development (GO:0042461)	2.71105164
65	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.71004003
66	acrosome reaction (GO:0007340)	2.69405186
67	cytochrome complex assembly (GO:0017004)	2.69320192
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.69201820
69	regulation of microtubule-based movement (GO:0060632)	2.67914399
70	regulation of neurotransmitter uptake (GO:0051580)	2.67490632
71	serotonin metabolic process (GO:0042428)	2.67160943
72	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.67009896
73	male meiosis I (GO:0007141)	2.66949650
74	mannosylation (GO:0097502)	2.66780848
75	nephron tubule morphogenesis (GO:0072078)	2.66714008
76	nephron epithelium morphogenesis (GO:0072088)	2.66714008
77	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.65532281
78	photoreceptor cell maintenance (GO:0045494)	2.64749083
79	ubiquinone biosynthetic process (GO:0006744)	2.64335529
80	regulation of hexokinase activity (GO:1903299)	2.61246926
81	regulation of glucokinase activity (GO:0033131)	2.61246926
82	dopamine transport (GO:0015872)	2.61115285
83	recombinational repair (GO:0000725)	2.60204049
84	double-strand break repair via homologous recombination (GO:0000724)	2.59727694
85	proline transport (GO:0015824)	2.58026693
86	regulation of telomere maintenance (GO:0032204)	2.57746877
87	protein K11-linked deubiquitination (GO:0035871)	2.56244314
88	inner ear receptor stereocilium organization (GO:0060122)	2.53706576
89	regulation of mesoderm development (GO:2000380)	2.52004658
90	ubiquinone metabolic process (GO:0006743)	2.51691951
91	regulation of hippo signaling (GO:0035330)	2.51270220
92	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.50971775
93	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.49502879
94	cell wall macromolecule metabolic process (GO:0044036)	2.45809760
95	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.45078825
96	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44472712
97	adaptation of signaling pathway (GO:0023058)	2.44001186
98	establishment of protein localization to Golgi (GO:0072600)	2.43525518
99	pyrimidine nucleobase catabolic process (GO:0006208)	2.43258226
100	neural tube formation (GO:0001841)	2.42633111

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.06460316
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24781274
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.70723990
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.58682851
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.58599639
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.56446211
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.47265154
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34794488
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.26174464
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.24117231
11	FUS_26573619_Chip-Seq_HEK293_Human	2.22254621
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.21879319
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14718467
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.09479453
15	P300_19829295_ChIP-Seq_ESCs_Human	2.03332960
16	EWS_26573619_Chip-Seq_HEK293_Human	1.95724512
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.95248679
18	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.93984709
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85530368
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84905616
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80752909
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.73813261
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70506334
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.68108440
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66668203
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.63480684
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.61964351
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60920105
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.60920105
30	STAT3_23295773_ChIP-Seq_U87_Human	1.53876004
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53258206
32	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51529371
33	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51529371
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.51490090
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.50157461
36	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.48851200
37	AR_25329375_ChIP-Seq_VCAP_Human	1.47524644
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45644185
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44512931
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44204627
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44204627
42	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.43324362
43	TCF4_23295773_ChIP-Seq_U87_Human	1.42754750
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.42712764
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.42712764
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41569938
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41285056
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39298855
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37465189
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35036571
51	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32555960
52	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.32013795
53	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30907824
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.30775832
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30746464
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.30624964
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30544200
58	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30490742
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30467081
60	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.30300046
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.29995364
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.29910541
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29665266
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29040122
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28827662
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27721272
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27335948
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27238825
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.26385708
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25315170
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23989960
72	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20512112
73	AR_20517297_ChIP-Seq_VCAP_Human	1.19903156
74	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.19685001
75	NCOR_22424771_ChIP-Seq_293T_Human	1.19400517
76	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19084945
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.15340728
78	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15223909
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13686754
80	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.12559003
81	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08402963
82	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.06874226
83	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.06277286
84	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.05495389
85	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04578466
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02970997
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.02912551
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.02571109
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02033833
90	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01713122
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01409859
92	AR_21572438_ChIP-Seq_LNCaP_Human	1.01303858
93	CDX2_22108803_ChIP-Seq_LS180_Human	1.00860164
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00464657
95	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.00436985
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.00021968
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.98302675
98	ERA_21632823_ChIP-Seq_H3396_Human	0.97604166
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.96929298
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96672388

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.07924497
2	MP0003195_calcinosis	2.98142830
3	MP0002102_abnormal_ear_morphology	2.65880551
4	MP0005551_abnormal_eye_electrophysiolog	2.61270369
5	MP0000569_abnormal_digit_pigmentation	2.58644526
6	MP0001968_abnormal_touch/_nociception	2.54931240
7	MP0005410_abnormal_fertilization	2.20758163
8	MP0008872_abnormal_physiological_respon	2.16906349
9	MP0002736_abnormal_nociception_after	2.13391568
10	MP0002876_abnormal_thyroid_physiology	1.99770730
11	MP0009046_muscle_twitch	1.98391085
12	MP0002837_dystrophic_cardiac_calcinosis	1.97335975
13	MP0009745_abnormal_behavioral_response	1.93990492
14	MP0005253_abnormal_eye_physiology	1.92215239
15	MP0001986_abnormal_taste_sensitivity	1.89516573
16	MP0008875_abnormal_xenobiotic_pharmacok	1.88454290
17	MP0002638_abnormal_pupillary_reflex	1.87791740
18	MP0005646_abnormal_pituitary_gland	1.85989980
19	MP0006072_abnormal_retinal_apoptosis	1.84334528
20	MP0003646_muscle_fatigue	1.82988687
21	MP0001501_abnormal_sleep_pattern	1.81376895
22	MP0003787_abnormal_imprinting	1.80566997
23	MP0004147_increased_porphyrin_level	1.79785069
24	MP0004043_abnormal_pH_regulation	1.79418693
25	MP0005645_abnormal_hypothalamus_physiol	1.78000674
26	MP0003011_delayed_dark_adaptation	1.76944279
27	MP0006292_abnormal_olfactory_placode	1.75434277
28	MP0004142_abnormal_muscle_tone	1.70314173
29	MP0001485_abnormal_pinna_reflex	1.68727442
30	MP0001486_abnormal_startle_reflex	1.66351402
31	MP0004885_abnormal_endolymph	1.64781997
32	MP0002272_abnormal_nervous_system	1.63255516
33	MP0000427_abnormal_hair_cycle	1.55161573
34	MP0002938_white_spotting	1.54811444
35	MP0005084_abnormal_gallbladder_morpholo	1.51514505
36	MP0006276_abnormal_autonomic_nervous	1.47809945
37	MP0005174_abnormal_tail_pigmentation	1.47256658
38	MP0003880_abnormal_central_pattern	1.46465399
39	MP0003136_yellow_coat_color	1.45573839
40	MP0001529_abnormal_vocalization	1.41887862
41	MP0002735_abnormal_chemical_nociception	1.40073761
42	MP0004133_heterotaxia	1.39280992
43	MP0002572_abnormal_emotion/affect_behav	1.37641565
44	MP0002653_abnormal_ependyma_morphology	1.36120609
45	MP0000372_irregular_coat_pigmentation	1.32927676
46	MP0002733_abnormal_thermal_nociception	1.32277250
47	MP0000631_abnormal_neuroendocrine_gland	1.29640130
48	MP0004742_abnormal_vestibular_system	1.29072750
49	MP0003718_maternal_effect	1.27354733
50	MP0001970_abnormal_pain_threshold	1.26884122
51	MP0001984_abnormal_olfaction	1.26871273
52	MP0002234_abnormal_pharynx_morphology	1.24654543
53	MP0002928_abnormal_bile_duct	1.24094526
54	MP0001905_abnormal_dopamine_level	1.22990419
55	MP0003698_abnormal_male_reproductive	1.22509690
56	MP0005379_endocrine/exocrine_gland_phen	1.21218779
57	MP0002557_abnormal_social/conspecific_i	1.20497659
58	MP0002064_seizures	1.16728460
59	MP0004924_abnormal_behavior	1.14970710
60	MP0005386_behavior/neurological_phenoty	1.14970710
61	MP0005377_hearing/vestibular/ear_phenot	1.14929507
62	MP0003878_abnormal_ear_physiology	1.14929507
63	MP0010386_abnormal_urinary_bladder	1.13166905
64	MP0002138_abnormal_hepatobiliary_system	1.12390904
65	MP0001929_abnormal_gametogenesis	1.10900269
66	MP0002067_abnormal_sensory_capabilities	1.08624247
67	MP0005167_abnormal_blood-brain_barrier	1.08507107
68	MP0005389_reproductive_system_phenotype	1.06474934
69	MP0002160_abnormal_reproductive_system	1.04661452
70	MP0000230_abnormal_systemic_arterial	1.01370423
71	MP0008775_abnormal_heart_ventricle	0.98905390
72	MP0008995_early_reproductive_senescence	0.98757604
73	MP0005195_abnormal_posterior_eye	0.98588445
74	MP0008058_abnormal_DNA_repair	0.97173173
75	MP0001324_abnormal_eye_pigmentation	0.95380407
76	MP0002063_abnormal_learning/memory/cond	0.94051725
77	MP0005075_abnormal_melanosome_morpholog	0.91469642
78	MP0000383_abnormal_hair_follicle	0.90915202
79	MP0002693_abnormal_pancreas_physiology	0.90498881
80	MP0002751_abnormal_autonomic_nervous	0.90348688
81	MP0004145_abnormal_muscle_electrophysio	0.89509821
82	MP0002163_abnormal_gland_morphology	0.89418749
83	MP0003635_abnormal_synaptic_transmissio	0.89367370
84	MP0003252_abnormal_bile_duct	0.88339759
85	MP0002095_abnormal_skin_pigmentation	0.85506283
86	MP0004215_abnormal_myocardial_fiber	0.85374654
87	MP0002909_abnormal_adrenal_gland	0.85260223
88	MP0003137_abnormal_impulse_conducting	0.85209965
89	MP0002734_abnormal_mechanical_nocicepti	0.85089224
90	MP0002210_abnormal_sex_determination	0.84404339
91	MP0005332_abnormal_amino_acid	0.83679385
92	MP0001764_abnormal_homeostasis	0.82655828
93	MP0000026_abnormal_inner_ear	0.82212677
94	MP0002277_abnormal_respiratory_mucosa	0.82123530
95	MP0001963_abnormal_hearing_physiology	0.82074986
96	MP0005085_abnormal_gallbladder_physiolo	0.81477426
97	MP0002752_abnormal_somatic_nervous	0.80603956
98	MP0002229_neurodegeneration	0.80196590
99	MP0005423_abnormal_somatic_nervous	0.77611994
100	MP0003121_genomic_imprinting	0.77159365

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.53421165
2	Pancreatic fibrosis (HP:0100732)	4.02188558
3	Molar tooth sign on MRI (HP:0002419)	4.00718269
4	Abnormality of midbrain morphology (HP:0002418)	4.00718269
5	Nephronophthisis (HP:0000090)	3.89555748
6	True hermaphroditism (HP:0010459)	3.81836556
7	Congenital stationary night blindness (HP:0007642)	3.80869450
8	Attenuation of retinal blood vessels (HP:0007843)	3.64342429
9	Type II lissencephaly (HP:0007260)	3.47824073
10	Abnormality of the renal medulla (HP:0100957)	3.37707999
11	Abnormality of the renal cortex (HP:0011035)	3.24276714
12	Hyperventilation (HP:0002883)	3.09063915
13	Medial flaring of the eyebrow (HP:0010747)	3.05507609
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.91606102
15	Chronic hepatic failure (HP:0100626)	2.88005692
16	Pendular nystagmus (HP:0012043)	2.85671839
17	Tubular atrophy (HP:0000092)	2.73231382
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.70720922
19	Abnormality of alanine metabolism (HP:0010916)	2.70720922
20	Hyperalaninemia (HP:0003348)	2.70720922
21	Cystic liver disease (HP:0006706)	2.70239724
22	Abolished electroretinogram (ERG) (HP:0000550)	2.65118421
23	Inability to walk (HP:0002540)	2.62459935
24	Gaze-evoked nystagmus (HP:0000640)	2.62003902
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58159686
26	Absent/shortened dynein arms (HP:0200106)	2.58159686
27	Abnormal drinking behavior (HP:0030082)	2.55380855
28	Polydipsia (HP:0001959)	2.55380855
29	Keratoconus (HP:0000563)	2.50912409
30	Increased corneal curvature (HP:0100692)	2.50912409
31	Large for gestational age (HP:0001520)	2.48209636
32	Sclerocornea (HP:0000647)	2.45062172
33	Congenital, generalized hypertrichosis (HP:0004540)	2.41778935
34	Gait imbalance (HP:0002141)	2.41019838
35	Bony spicule pigmentary retinopathy (HP:0007737)	2.38162644
36	Cerebellar dysplasia (HP:0007033)	2.34858263
37	Congenital primary aphakia (HP:0007707)	2.33360245
38	Decreased central vision (HP:0007663)	2.30522843
39	Progressive cerebellar ataxia (HP:0002073)	2.27089217
40	Hypothermia (HP:0002045)	2.24660723
41	Furrowed tongue (HP:0000221)	2.23763826
42	Lissencephaly (HP:0001339)	2.21047623
43	Progressive inability to walk (HP:0002505)	2.20470113
44	Renal cortical cysts (HP:0000803)	2.20088661
45	Polyuria (HP:0000103)	2.17185887
46	Anencephaly (HP:0002323)	2.16755582
47	Congenital hepatic fibrosis (HP:0002612)	2.14235021
48	Genetic anticipation (HP:0003743)	2.12716208
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10854491
50	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10061887
51	Decreased circulating renin level (HP:0003351)	2.08757154
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08719078
53	Optic nerve hypoplasia (HP:0000609)	2.08139915
54	Nephrogenic diabetes insipidus (HP:0009806)	2.07373700
55	Optic disc pallor (HP:0000543)	2.06462609
56	Abnormal respiratory motile cilium morphology (HP:0005938)	2.04269939
57	Abnormal respiratory epithelium morphology (HP:0012253)	2.04269939
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04145357
59	Broad-based gait (HP:0002136)	2.00074811
60	Methylmalonic acidemia (HP:0002912)	1.98152953
61	Postaxial foot polydactyly (HP:0001830)	1.97264135
62	Male pseudohermaphroditism (HP:0000037)	1.97132917
63	Genital tract atresia (HP:0001827)	1.96056941
64	Severe muscular hypotonia (HP:0006829)	1.95955375
65	Febrile seizures (HP:0002373)	1.94648418
66	Protruding tongue (HP:0010808)	1.93074567
67	Acute necrotizing encephalopathy (HP:0006965)	1.92994538
68	Abnormality of the pons (HP:0007361)	1.92805724
69	Congenital sensorineural hearing impairment (HP:0008527)	1.92302894
70	Increased CSF lactate (HP:0002490)	1.92172555
71	Abnormality of macular pigmentation (HP:0008002)	1.91783948
72	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.91430881
73	Patellar aplasia (HP:0006443)	1.89535537
74	Vaginal atresia (HP:0000148)	1.88544774
75	Absent speech (HP:0001344)	1.88311725
76	Fair hair (HP:0002286)	1.88096117
77	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.87721365
78	Hypoplasia of the fovea (HP:0007750)	1.87721365
79	Hypoplasia of the pons (HP:0012110)	1.87275399
80	Aplasia/Hypoplasia of the patella (HP:0006498)	1.85432167
81	Mitochondrial inheritance (HP:0001427)	1.85028537
82	Chorioretinal atrophy (HP:0000533)	1.84907601
83	Abnormal ciliary motility (HP:0012262)	1.83946184
84	Bile duct proliferation (HP:0001408)	1.82269476
85	Abnormal biliary tract physiology (HP:0012439)	1.82269476
86	Progressive macrocephaly (HP:0004481)	1.80521796
87	Intestinal atresia (HP:0011100)	1.79849544
88	Methylmalonic aciduria (HP:0012120)	1.79831781
89	Severe visual impairment (HP:0001141)	1.79157286
90	Abnormal urine output (HP:0012590)	1.78461481
91	Retinal dysplasia (HP:0007973)	1.78427988
92	Acute encephalopathy (HP:0006846)	1.77576530
93	Abnormality of the labia minora (HP:0012880)	1.76582765
94	Concave nail (HP:0001598)	1.76430716
95	Stomach cancer (HP:0012126)	1.75023636
96	Ketoacidosis (HP:0001993)	1.71944498
97	Focal motor seizures (HP:0011153)	1.71300308
98	Widely spaced teeth (HP:0000687)	1.71002256
99	Hemiparesis (HP:0001269)	1.69680721
100	Constricted visual fields (HP:0001133)	1.68984744

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.72582557
2	ADRBK2	3.59794710
3	MAP4K2	3.36777271
4	BMPR1B	3.33780307
5	ZAK	2.84102315
6	ACVR1B	2.73038007
7	GRK1	2.41926448
8	NUAK1	2.38327792
9	WNK3	2.36096351
10	WNK4	2.32120707
11	TLK1	2.24405624
12	INSRR	2.23294499
13	PINK1	1.93673423
14	MAPK13	1.86813382
15	TXK	1.80145806
16	TAOK3	1.73775022
17	MAP3K4	1.71863223
18	CASK	1.66673160
19	OXSR1	1.61084227
20	PNCK	1.53638676
21	DAPK2	1.50561493
22	MKNK2	1.35842664
23	STK39	1.34176113
24	PLK4	1.23929782
25	TRIM28	1.23798720
26	ADRBK1	1.23578630
27	PAK3	1.17984750
28	DYRK2	1.12587724
29	TGFBR1	1.11947478
30	TNIK	1.08452644
31	PLK2	1.07749786
32	CAMKK2	0.97258823
33	MAP2K7	0.94053833
34	VRK1	0.94048553
35	PRKCG	0.92235671
36	NTRK3	0.91661197
37	MUSK	0.90755955
38	STK38L	0.88072263
39	PTK2B	0.88019250
40	PRKCE	0.87796417
41	PHKG1	0.87267932
42	PHKG2	0.87267932
43	MAP2K6	0.83059309
44	MST4	0.81438132
45	BRSK2	0.80697246
46	MARK1	0.78214687
47	BCKDK	0.78206897
48	TIE1	0.77313754
49	CSNK1G1	0.76815892
50	CSNK1G2	0.76038812
51	MAPKAPK3	0.74893235
52	MAPK15	0.74435036
53	IRAK1	0.73615171
54	FGFR2	0.68137551
55	VRK2	0.67421062
56	MAPKAPK5	0.67340733
57	CSNK1G3	0.64193451
58	NME1	0.64139156
59	PLK3	0.64135594
60	STK3	0.62300511
61	NEK2	0.62152823
62	MKNK1	0.57854485
63	PIK3CA	0.57639302
64	IKBKB	0.57048047
65	ERBB3	0.55915680
66	TAF1	0.55485197
67	KIT	0.54981251
68	RPS6KA5	0.53028166
69	CAMK2A	0.52970851
70	NTRK2	0.52957970
71	PRKCQ	0.52743909
72	GRK7	0.52175830
73	CSNK1A1L	0.50311084
74	NLK	0.48939515
75	EIF2AK3	0.48536771
76	WEE1	0.48316578
77	TEC	0.46603759
78	SIK2	0.45090680
79	CAMK1	0.44578413
80	STK16	0.44231896
81	PRKCI	0.44210407
82	TRPM7	0.43552369
83	PKN1	0.42455251
84	PRKACA	0.40284052
85	PRKAA2	0.39533515
86	CSNK1D	0.39210774
87	FER	0.38756427
88	WNK1	0.37572715
89	PRKG1	0.37456841
90	CSNK1A1	0.36174816
91	PIK3CG	0.34585797
92	CDK19	0.33682031
93	CDK3	0.33598475
94	CHUK	0.33350177
95	BCR	0.32528156
96	STK11	0.31697562
97	PRKAA1	0.31181286
98	PRKCA	0.29921185
99	GRK5	0.29899341
100	SYK	0.29435225

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.97779471
2	Phototransduction_Homo sapiens_hsa04744	2.96370489
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.62286135
4	Butanoate metabolism_Homo sapiens_hsa00650	2.60308676
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52314318
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43878892
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.43466057
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.22681619
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.16281587
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.12522599
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.11686770
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.09839195
13	Homologous recombination_Homo sapiens_hsa03440	1.97824048
14	Nicotine addiction_Homo sapiens_hsa05033	1.97703769
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.97171871
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.93782051
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.85889455
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83535932
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.81535568
20	Basal transcription factors_Homo sapiens_hsa03022	1.78530180
21	Protein export_Homo sapiens_hsa03060	1.69233910
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56322411
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49976197
24	Parkinsons disease_Homo sapiens_hsa05012	1.47666735
25	Olfactory transduction_Homo sapiens_hsa04740	1.46274123
26	Taste transduction_Homo sapiens_hsa04742	1.43711562
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42077907
28	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.40632000
29	Caffeine metabolism_Homo sapiens_hsa00232	1.39140519
30	Propanoate metabolism_Homo sapiens_hsa00640	1.36412480
31	RNA polymerase_Homo sapiens_hsa03020	1.34899792
32	Morphine addiction_Homo sapiens_hsa05032	1.29639181
33	One carbon pool by folate_Homo sapiens_hsa00670	1.22061563
34	RNA degradation_Homo sapiens_hsa03018	1.17334759
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.16951807
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16466489
37	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.13319018
38	ABC transporters_Homo sapiens_hsa02010	1.12011908
39	Peroxisome_Homo sapiens_hsa04146	1.10693028
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.10346959
41	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08703157
42	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05998861
43	Serotonergic synapse_Homo sapiens_hsa04726	1.04469228
44	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.02677964
45	Huntingtons disease_Homo sapiens_hsa05016	1.02543287
46	Circadian entrainment_Homo sapiens_hsa04713	0.98895171
47	Regulation of autophagy_Homo sapiens_hsa04140	0.98116396
48	Insulin secretion_Homo sapiens_hsa04911	0.97988930
49	GABAergic synapse_Homo sapiens_hsa04727	0.97961389
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.97694498
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96877527
52	Retinol metabolism_Homo sapiens_hsa00830	0.96690598
53	Alzheimers disease_Homo sapiens_hsa05010	0.89154804
54	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.89067858
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88223509
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.84351211
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.82887903
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.78864483
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78754429
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.78039440
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.76419081
62	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.75701128
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74517896
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73657199
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73650854
66	Sulfur metabolism_Homo sapiens_hsa00920	0.72915152
67	Asthma_Homo sapiens_hsa05310	0.72163071
68	Purine metabolism_Homo sapiens_hsa00230	0.70115422
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.64505331
70	Salivary secretion_Homo sapiens_hsa04970	0.64303688
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.62628588
72	Metabolic pathways_Homo sapiens_hsa01100	0.60012391
73	Circadian rhythm_Homo sapiens_hsa04710	0.59328351
74	Proteasome_Homo sapiens_hsa03050	0.58463475
75	Mineral absorption_Homo sapiens_hsa04978	0.58333328
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57703595
77	Histidine metabolism_Homo sapiens_hsa00340	0.56264936
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55656754
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.54143664
80	Primary immunodeficiency_Homo sapiens_hsa05340	0.52030977
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.50354516
82	Fatty acid degradation_Homo sapiens_hsa00071	0.50042460
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49068698
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.47179940
85	Dopaminergic synapse_Homo sapiens_hsa04728	0.46064570
86	Allograft rejection_Homo sapiens_hsa05330	0.45323062
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.44634641
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.44232121
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43175721
90	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43043672
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.42302129
92	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.41085626
93	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40723495
94	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.37786840
95	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37472766
96	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.37431376
97	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.36599528
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36540891
99	cAMP signaling pathway_Homo sapiens_hsa04024	0.33562968
100	Cocaine addiction_Homo sapiens_hsa05030	0.33236963

C17ORF105

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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