C17ORF107

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.36241273
2response to peptidoglycan (GO:0032494)4.80299599
3cellular extravasation (GO:0045123)4.34139320
4regulation of T-helper 2 cell differentiation (GO:0045628)4.30450466
5positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.20761035
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.10251068
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.10251068
8modulation by symbiont of host immune response (GO:0052553)4.10251068
9positive regulation by symbiont of host defense response (GO:0052509)4.10251068
10modulation by symbiont of host defense response (GO:0052031)4.10251068
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.10251068
12macrophage activation involved in immune response (GO:0002281)3.73395363
13negative regulation of interleukin-12 production (GO:0032695)3.70909326
14positive regulation of heat generation (GO:0031652)3.67033367
15regulation of vitamin D biosynthetic process (GO:0060556)3.61489769
16germinal center formation (GO:0002467)3.57573670
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.57370214
18response to muramyl dipeptide (GO:0032495)3.51815312
19detection of external biotic stimulus (GO:0098581)3.51637001
20detection of biotic stimulus (GO:0009595)3.51560610
21regulation of fever generation (GO:0031620)3.22698027
22positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.13812888
23macrophage activation (GO:0042116)3.08139567
24neutrophil mediated immunity (GO:0002446)3.05990336
25detection of other organism (GO:0098543)3.05470974
26positive regulation of acute inflammatory response (GO:0002675)3.01934242
27positive regulation of gamma-delta T cell activation (GO:0046645)3.01598959
28regulation of interferon-beta biosynthetic process (GO:0045357)3.01116539
29embryonic process involved in female pregnancy (GO:0060136)3.00718028
30negative regulation of erythrocyte differentiation (GO:0045647)2.98363738
31positive regulation of cellular amide metabolic process (GO:0034250)2.96075119
32negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.95930630
33regulation of gamma-delta T cell activation (GO:0046643)2.90186043
34negative regulation of toll-like receptor signaling pathway (GO:0034122)2.89256066
35T-helper 1 type immune response (GO:0042088)2.89233571
36regulation of vitamin metabolic process (GO:0030656)2.81493137
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80710649
38response to laminar fluid shear stress (GO:0034616)2.76563294
39positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75049784
40positive regulation of NF-kappaB import into nucleus (GO:0042346)2.74675043
41positive regulation of type 2 immune response (GO:0002830)2.74364566
42regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74316550
43NIK/NF-kappaB signaling (GO:0038061)2.67839613
44negative regulation of cell killing (GO:0031342)2.67651150
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67651150
46response to host immune response (GO:0052572)2.65740350
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.65740350
48regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.65728064
49response to manganese ion (GO:0010042)2.64124991
50neutrophil chemotaxis (GO:0030593)2.63604971
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.59639823
52response to host (GO:0075136)2.59639823
53response to host defenses (GO:0052200)2.59639823
54positive regulation vascular endothelial growth factor production (GO:0010575)2.59149965
55negative regulation of lipid catabolic process (GO:0050995)2.56213969
56leukocyte aggregation (GO:0070486)2.55482400
57neutrophil migration (GO:1990266)2.55377425
58positive regulation of chemokine biosynthetic process (GO:0045080)2.55040343
59granulocyte activation (GO:0036230)2.54965159
60positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.54296645
61regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53571376
62regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.52016213
63tolerance induction (GO:0002507)2.51031084
64myeloid leukocyte mediated immunity (GO:0002444)2.49265032
65neutrophil activation (GO:0042119)2.49091412
66regulation of macrophage cytokine production (GO:0010935)2.46935868
67regulation of heat generation (GO:0031650)2.46747303
68negative regulation of interleukin-6 production (GO:0032715)2.45964136
69decidualization (GO:0046697)2.45502210
70regulation of ARF GTPase activity (GO:0032312)2.45107820
71histone demethylation (GO:0016577)2.44329555
72mRNA transcription (GO:0009299)2.43961980
73regulation of NF-kappaB import into nucleus (GO:0042345)2.43371088
74regulation of vascular endothelial growth factor production (GO:0010574)2.43155376
75regulation of membrane protein ectodomain proteolysis (GO:0051043)2.42212632
76detection of bacterium (GO:0016045)2.41536971
77neutrophil activation involved in immune response (GO:0002283)2.41252335
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.40777177
79negative regulation of cytokine production involved in immune response (GO:0002719)2.38919206
80regulation of type 2 immune response (GO:0002828)2.38251718
81interleukin-1-mediated signaling pathway (GO:0070498)2.37993372
82regulation of interleukin-6 biosynthetic process (GO:0045408)2.37816554
83negative regulation of interleukin-8 production (GO:0032717)2.37263511
84regulation of toll-like receptor signaling pathway (GO:0034121)2.37039222
85histone lysine demethylation (GO:0070076)2.36193432
86ovulation (GO:0030728)2.35853725
87histone H3-K36 demethylation (GO:0070544)2.35091522
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34875152
89positive regulation of macrophage cytokine production (GO:0060907)2.34730687
90regulation of interleukin-8 biosynthetic process (GO:0045414)2.33726666
91cellular response to arsenic-containing substance (GO:0071243)2.33658207
92negative regulation of interleukin-1 production (GO:0032692)2.32919148
93positive regulation of nitric oxide biosynthetic process (GO:0045429)2.31821884
94cellular response to epinephrine stimulus (GO:0071872)2.31202428
95regulation of chemokine biosynthetic process (GO:0045073)2.29960806
96myeloid cell activation involved in immune response (GO:0002275)2.28989562
97negative regulation of interleukin-1 beta production (GO:0032691)2.26320902
98low-density lipoprotein particle clearance (GO:0034383)2.25233083
99positive regulation of transcription factor import into nucleus (GO:0042993)2.24560025
100defense response to protozoan (GO:0042832)2.23871907

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.01095254
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.79604297
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.78507510
4STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43294971
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39198866
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21932897
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.18758862
8TCF7_22412390_ChIP-Seq_EML_Mouse2.16117207
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15815202
10LXR_22292898_ChIP-Seq_THP-1_Human2.14177224
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.12144040
12VDR_21846776_ChIP-Seq_THP-1_Human2.10142871
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.05388131
14VDR_24763502_ChIP-Seq_THP-1_Human2.04889135
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.00604490
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.99298137
17ELK3_25401928_ChIP-Seq_HUVEC_Human1.99017667
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97722035
19KDM2B_26808549_Chip-Seq_DND41_Human1.96098892
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95766614
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95177339
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90778045
23MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89331075
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85592577
25KDM2B_26808549_Chip-Seq_K562_Human1.80570585
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72889501
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.72595726
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.71851747
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71603990
30MYC_22102868_ChIP-Seq_BL_Human1.71311808
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66863706
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.62512837
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57307621
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56241543
35RACK7_27058665_Chip-Seq_MCF-7_Human1.56000099
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.54876413
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52161224
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51088228
39* MAF_26560356_Chip-Seq_TH1_Human1.49384337
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.49205288
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.46954240
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45908235
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45373106
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45257347
45RUNX_20019798_ChIP-Seq_JUKART_Human1.42178253
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.40434778
47TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.37937123
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36289003
49ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.35488015
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34823740
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.32279382
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29902869
53SPI1_23127762_ChIP-Seq_K562_Human1.29351621
54GATA1_19941827_ChIP-Seq_MEL_Mouse1.28277866
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27708558
56GATA1_19941826_ChIP-Seq_K562_Human1.26945355
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26598885
58RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25402265
59SCL_19346495_ChIP-Seq_HPC-7_Human1.25245882
60VDR_24787735_ChIP-Seq_THP-1_Human1.24133440
61UTX_26944678_Chip-Seq_JUKART_Human1.23118956
62MAF_26560356_Chip-Seq_TH2_Human1.21409652
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20495246
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17807043
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17639348
66SMC4_20622854_ChIP-Seq_HELA_Human1.17521133
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17504173
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.15863881
69LXR_22158963_ChIP-Seq_LIVER_Mouse1.15490685
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15203228
71CREB1_26743006_Chip-Seq_LNCaP_Human1.15159509
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14964160
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.14923936
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14875847
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14788433
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13893415
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.12781649
78CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09472261
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08739073
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08739073
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08739073
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08725222
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07833114
84CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07497674
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.06750983
86P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05757087
87CLOCK_20551151_ChIP-Seq_293T_Human1.05747522
88ATF3_27146783_Chip-Seq_COLON_Human1.05153986
89DROSHA_22980978_ChIP-Seq_HELA_Human1.04073369
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04056807
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03892347
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03472597
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02579544
94DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99322003
95BCOR_27268052_Chip-Seq_Bcells_Human0.98739577
96* P68_20966046_ChIP-Seq_HELA_Human0.98547439
97NCOR1_26117541_ChIP-Seq_K562_Human0.97786576
98ESR1_21235772_ChIP-Seq_MCF-7_Human0.96313456
99SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95822999
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95713336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.19650342
2MP0003724_increased_susceptibility_to3.83545474
3MP0008004_abnormal_stomach_pH3.83083044
4MP0003436_decreased_susceptibility_to3.56665210
5MP0009278_abnormal_bone_marrow3.10878104
6MP0003705_abnormal_hypodermis_morpholog2.98193848
7MP0009840_abnormal_foam_cell2.83444283
8MP0008260_abnormal_autophagy2.48967529
9MP0004510_myositis2.26268151
10MP0002254_reproductive_system_inflammat2.24568886
11MP0004947_skin_inflammation2.24480420
12MP0010352_gastrointestinal_tract_polyps2.14025305
13MP0002419_abnormal_innate_immunity2.12615598
14MP0003300_gastrointestinal_ulcer2.11411851
15MP0005451_abnormal_body_composition2.10893323
16MP0003075_altered_response_to2.04691044
17MP0001533_abnormal_skeleton_physiology1.95033595
18MP0005076_abnormal_cell_differentiation1.91664402
19MP0003656_abnormal_erythrocyte_physiolo1.89518329
20MP0005000_abnormal_immune_tolerance1.78791146
21MP0009764_decreased_sensitivity_to1.73678323
22MP0003172_abnormal_lysosome_physiology1.71701192
23MP0002138_abnormal_hepatobiliary_system1.71100433
24MP0003828_pulmonary_edema1.70383591
25MP0002998_abnormal_bone_remodeling1.63030061
26MP0005025_abnormal_response_to1.61798682
27MP0005166_decreased_susceptibility_to1.60657656
28MP0005058_abnormal_lysosome_morphology1.60215738
29MP0001545_abnormal_hematopoietic_system1.59178849
30MP0005397_hematopoietic_system_phenotyp1.59178849
31MP0009785_altered_susceptibility_to1.57493514
32MP0003191_abnormal_cellular_cholesterol1.56404311
33MP0002148_abnormal_hypersensitivity_rea1.52960641
34MP0003091_abnormal_cell_migration1.52162640
35MP0005464_abnormal_platelet_physiology1.50275233
36MP0002332_abnormal_exercise_endurance1.45396692
37MP0000685_abnormal_immune_system1.43472046
38MP0006082_CNS_inflammation1.42995348
39MP0002723_abnormal_immune_serum1.41597105
40MP0002132_abnormal_respiratory_system1.40142548
41MP0001853_heart_inflammation1.37725264
42MP0001835_abnormal_antigen_presentation1.36838299
43MP0002405_respiratory_system_inflammati1.35016119
44MP0008438_abnormal_cutaneous_collagen1.34051220
45MP0002452_abnormal_antigen_presenting1.33975397
46MP0003453_abnormal_keratinocyte_physiol1.33609760
47MP0005164_abnormal_response_to1.31102816
48MP0003566_abnormal_cell_adhesion1.28289968
49MP0001800_abnormal_humoral_immune1.28039300
50MP0000678_abnormal_parathyroid_gland1.26505246
51MP0001790_abnormal_immune_system1.26391218
52MP0005387_immune_system_phenotype1.26391218
53MP0002006_tumorigenesis1.24862614
54MP0010155_abnormal_intestine_physiology1.21924652
55MP0000465_gastrointestinal_hemorrhage1.20982335
56MP0004233_abnormal_muscle_weight1.20838923
57MP0000858_altered_metastatic_potential1.18275384
58MP0009333_abnormal_splenocyte_physiolog1.17968186
59MP0005023_abnormal_wound_healing1.17618066
60MP0001851_eye_inflammation1.17102380
61MP0002420_abnormal_adaptive_immunity1.16996226
62MP0001819_abnormal_immune_cell1.16993637
63MP0005390_skeleton_phenotype1.11849149
64MP0001845_abnormal_inflammatory_respons1.10778730
65MP0008469_abnormal_protein_level1.07529991
66MP0003045_fibrosis1.04868726
67MP0010234_abnormal_vibrissa_follicle1.00309271
68MP0003448_altered_tumor_morphology0.99605429
69MP0005167_abnormal_blood-brain_barrier0.99199880
70MP0000604_amyloidosis0.98884178
71MP0005310_abnormal_salivary_gland0.97071428
72MP0005409_darkened_coat_color0.96768123
73MP0005410_abnormal_fertilization0.95700687
74MP0001849_ear_inflammation0.94311375
75MP0005275_abnormal_skin_tensile0.92999316
76MP0002060_abnormal_skin_morphology0.92048066
77MP0003279_aneurysm0.91151790
78MP0000249_abnormal_blood_vessel0.90839011
79MP0002009_preneoplasia0.83668710
80MP0004883_abnormal_blood_vessel0.83031562
81MP0002796_impaired_skin_barrier0.82764844
82MP0008874_decreased_physiological_sensi0.82607536
83MP0000343_altered_response_to0.81210129
84MP0003690_abnormal_glial_cell0.80442977
85MP0004858_abnormal_nervous_system0.80425282
86MP0000716_abnormal_immune_system0.80358365
87MP0005666_abnormal_adipose_tissue0.79962883
88MP0001958_emphysema0.79345959
89MP0005671_abnormal_response_to0.78401753
90MP0003329_amyloid_beta_deposits0.77771546
91MP0009765_abnormal_xenobiotic_induced0.75514280
92MP0005535_abnormal_body_temperature0.75231875
93MP0002933_joint_inflammation0.75172595
94MP0004808_abnormal_hematopoietic_stem0.74187776
95MP0000767_abnormal_smooth_muscle0.74160191
96MP0003763_abnormal_thymus_physiology0.73825839
97MP0002398_abnormal_bone_marrow0.73609323
98MP0004264_abnormal_extraembryonic_tissu0.72148059
99MP0002166_altered_tumor_susceptibility0.71959397
100MP0000750_abnormal_muscle_regeneration0.71891116

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)3.92045871
2Retrobulbar optic neuritis (HP:0100654)3.67733221
3Optic neuritis (HP:0100653)3.67733221
4Myositis (HP:0100614)3.55581161
5Amyloidosis (HP:0011034)3.39823268
6Elevated erythrocyte sedimentation rate (HP:0003565)3.36754213
7Abnormality of macrophages (HP:0004311)3.27891006
8Stomatitis (HP:0010280)3.25619866
9Thin bony cortex (HP:0002753)3.14976521
10Eczematoid dermatitis (HP:0000976)3.08238534
11Segmental peripheral demyelination/remyelination (HP:0003481)3.06030339
12Peritonitis (HP:0002586)2.92127732
13Obstructive sleep apnea (HP:0002870)2.89360179
14Mediastinal lymphadenopathy (HP:0100721)2.82262901
15Keratoconjunctivitis sicca (HP:0001097)2.71863964
16Deep venous thrombosis (HP:0002625)2.61076534
17Gastrointestinal infarctions (HP:0005244)2.59271526
18Systemic lupus erythematosus (HP:0002725)2.54500778
19Recurrent bacterial skin infections (HP:0005406)2.44109864
20Keratoconjunctivitis (HP:0001096)2.42915472
21Episodic fever (HP:0001954)2.42820696
22Recurrent gram-negative bacterial infections (HP:0005420)2.38789446
23Abnormality of the peritoneum (HP:0002585)2.37661879
24Gangrene (HP:0100758)2.37321405
25Recurrent abscess formation (HP:0002722)2.36659930
26Gingivitis (HP:0000230)2.32525375
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24194519
28Increased IgE level (HP:0003212)2.19284745
29Peripheral hypomyelination (HP:0007182)2.14895013
30Vasculitis (HP:0002633)2.14304380
31Arterial thrombosis (HP:0004420)2.10411945
32Abnormality of monocarboxylic acid metabolism (HP:0010996)2.08309136
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07503518
34Abnormality of polysaccharide metabolism (HP:0011012)2.07503518
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07503518
36Hemorrhage of the eye (HP:0011885)2.07047093
37Broad face (HP:0000283)2.06949305
38Genu recurvatum (HP:0002816)2.06147113
39Pulmonary embolism (HP:0002204)2.06111428
40Hemoptysis (HP:0002105)2.05543702
41Spondylolisthesis (HP:0003302)2.04504449
42Dilatation of the ascending aorta (HP:0005111)2.04412449
43Myocardial infarction (HP:0001658)2.03438157
44Cerebral aneurysm (HP:0004944)2.02270252
45Mucopolysacchariduria (HP:0008155)2.02034267
46Urinary glycosaminoglycan excretion (HP:0003541)2.02034267
47Premature rupture of membranes (HP:0001788)2.00930445
48Pulmonary infiltrates (HP:0002113)1.98267695
49Slow saccadic eye movements (HP:0000514)1.97392302
50Protrusio acetabuli (HP:0003179)1.95699873
51Increased CSF protein (HP:0002922)1.90938137
52Gingival bleeding (HP:0000225)1.90717345
53Onion bulb formation (HP:0003383)1.87945086
54Glomerulopathy (HP:0100820)1.86505504
55Urticaria (HP:0001025)1.85959036
56Asymmetric septal hypertrophy (HP:0001670)1.85829895
57Increased connective tissue (HP:0009025)1.82119043
58Cervical subluxation (HP:0003308)1.81366084
59Ulnar bowing (HP:0003031)1.81124507
60Abnormality of the fingertips (HP:0001211)1.80612193
61Acne (HP:0001061)1.80600638
62Malnutrition (HP:0004395)1.80538086
63Spontaneous hematomas (HP:0007420)1.80453876
64Aneurysm (HP:0002617)1.80331515
65Recurrent skin infections (HP:0001581)1.79432291
66Decreased motor nerve conduction velocity (HP:0003431)1.77232870
67Anorexia (HP:0002039)1.76241282
68Increased cerebral lipofuscin (HP:0011813)1.75870529
69Dysostosis multiplex (HP:0000943)1.74497253
70Abnormality of complement system (HP:0005339)1.73527404
71Thick nail (HP:0001805)1.73290178
72Spinal cord lesions (HP:0100561)1.73242500
73Syringomyelia (HP:0003396)1.73242500
74Polygenic inheritance (HP:0010982)1.71964385
75Anomalous pulmonary venous return (HP:0010772)1.70835029
76Cellulitis (HP:0100658)1.69039358
77Increased variability in muscle fiber diameter (HP:0003557)1.68201825
78Loss of speech (HP:0002371)1.66950211
79Emphysema (HP:0002097)1.66572620
80Persistence of primary teeth (HP:0006335)1.66482336
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66386588
82Supranuclear gaze palsy (HP:0000605)1.66343644
83Vertebral compression fractures (HP:0002953)1.66078732
84Neuronal loss in central nervous system (HP:0002529)1.65650273
85Aortic aneurysm (HP:0004942)1.65485152
86Progressive sensorineural hearing impairment (HP:0000408)1.64339099
87Blue sclerae (HP:0000592)1.63893071
88Germ cell neoplasia (HP:0100728)1.63873590
89Axonal loss (HP:0003447)1.63577610
90Mitral valve prolapse (HP:0001634)1.63294620
91Shallow orbits (HP:0000586)1.62602639
92Increased serum ferritin (HP:0003281)1.62007605
93Abnormality of the columella (HP:0009929)1.61231600
94Mitral stenosis (HP:0001718)1.61098151
95Abnormality of the costochondral junction (HP:0000919)1.60830254
96Colitis (HP:0002583)1.60632762
97Epistaxis (HP:0000421)1.60388197
98Distal lower limb muscle weakness (HP:0009053)1.60233638
99Esophageal varix (HP:0002040)1.60144459
100Hypertriglyceridemia (HP:0002155)1.59700059

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.39451664
2IRAK33.18365855
3ERN12.92701059
4RIPK42.38671070
5MAP3K32.17241781
6MAP2K32.00011866
7TAOK21.96003485
8TAOK11.94826061
9IRAK21.94030322
10MAP3K141.92596637
11TRIB31.90650943
12SIK11.89730952
13CDK121.89112865
14IRAK41.86729758
15KSR21.85696519
16MAP4K11.81637895
17MAP3K11.76599645
18BLK1.72176205
19MAP3K131.66347043
20ZAP701.65186191
21IRAK11.54727367
22RIPK11.52986882
23MARK21.52014320
24PIK3CG1.42914879
25LATS21.42420148
26EPHB11.42195036
27MAP3K111.41648629
28MAP3K21.40600906
29TBK11.39591729
30ARAF1.38014033
31IKBKE1.34287054
32SMG11.31101838
33MAP3K91.29167984
34BMPR21.28836356
35FGFR41.26223551
36DDR21.25023006
37WNK11.15045773
38PRKD21.14405222
39TYK21.14110997
40IKBKB1.12658667
41CSK1.12058283
42ICK1.10431807
43TXK1.04649820
44CHUK1.03876501
45SIK31.01793922
46JAK31.01247390
47CDC42BPA0.99060203
48PDPK10.98546029
49RPS6KA20.95569543
50JAK10.93732653
51MAP3K60.91704536
52STK380.89730494
53JAK20.84570549
54PDK10.84175450
55MAPK70.83681932
56RPS6KL10.83292333
57RPS6KC10.83292333
58TTN0.77746991
59GRK60.74271255
60MAPK150.72294184
61HIPK20.70753581
62MATK0.70234263
63NLK0.70177838
64MTOR0.69846899
65HCK0.69835625
66INSRR0.69680054
67MAPK120.68718489
68TNK20.68623561
69MAP2K20.68557044
70FES0.67309979
71EEF2K0.66885272
72FGFR30.66839727
73CAMK1D0.66702570
74PDGFRA0.66397322
75RAF10.64178239
76RPS6KA60.63734960
77FGR0.62283744
78SGK30.62143910
79MAP3K70.61939448
80PRKD30.61591379
81TESK20.61216728
82DYRK1B0.57838962
83DAPK20.56166810
84CAMKK10.52474094
85BRD40.51839798
86SGK4940.51343562
87SGK2230.51343562
88PRKG20.50836175
89MOS0.50447647
90RPS6KA10.50395943
91PDK20.50138367
92PRKAA20.50118961
93PDGFRB0.48212234
94PAK60.47872587
95CAMK40.47601173
96EPHA30.47304967
97MAP3K50.46640498
98STK110.44811481
99NEK60.44594838
100SIK20.41587166

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.40639689
2Osteoclast differentiation_Homo sapiens_hsa043802.30873838
3Leishmaniasis_Homo sapiens_hsa051402.13822532
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01342262
5NOD-like receptor signaling pathway_Homo sapiens_hsa046211.97868298
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.89925247
7TNF signaling pathway_Homo sapiens_hsa046681.84703525
8Legionellosis_Homo sapiens_hsa051341.76839650
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.69922648
10Acute myeloid leukemia_Homo sapiens_hsa052211.68412457
11Staphylococcus aureus infection_Homo sapiens_hsa051501.60686913
12Pertussis_Homo sapiens_hsa051331.60348515
13Malaria_Homo sapiens_hsa051441.60340365
14B cell receptor signaling pathway_Homo sapiens_hsa046621.58766710
15Prion diseases_Homo sapiens_hsa050201.54028648
16VEGF signaling pathway_Homo sapiens_hsa043701.52948907
17Tuberculosis_Homo sapiens_hsa051521.51586182
18Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48483839
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42660754
20Influenza A_Homo sapiens_hsa051641.40947070
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39633377
22Amoebiasis_Homo sapiens_hsa051461.36038115
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.31670775
24Other glycan degradation_Homo sapiens_hsa005111.27796848
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23081050
26Toxoplasmosis_Homo sapiens_hsa051451.22818755
27Prolactin signaling pathway_Homo sapiens_hsa049171.20892786
28Chronic myeloid leukemia_Homo sapiens_hsa052201.19617328
29Salmonella infection_Homo sapiens_hsa051321.18886630
30Type II diabetes mellitus_Homo sapiens_hsa049301.16267580
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.15950923
32Hepatitis B_Homo sapiens_hsa051611.15480584
33Graft-versus-host disease_Homo sapiens_hsa053321.12456961
34Bladder cancer_Homo sapiens_hsa052191.08764122
35Complement and coagulation cascades_Homo sapiens_hsa046101.07548219
36Renal cell carcinoma_Homo sapiens_hsa052111.06914988
37Hepatitis C_Homo sapiens_hsa051601.06560770
38Non-small cell lung cancer_Homo sapiens_hsa052231.04563899
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04090393
40Neurotrophin signaling pathway_Homo sapiens_hsa047221.03938397
41African trypanosomiasis_Homo sapiens_hsa051431.03886412
42mTOR signaling pathway_Homo sapiens_hsa041501.03566233
43GnRH signaling pathway_Homo sapiens_hsa049121.02668229
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.00145784
45Chemokine signaling pathway_Homo sapiens_hsa040620.98623512
46T cell receptor signaling pathway_Homo sapiens_hsa046600.98478550
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97740471
48Jak-STAT signaling pathway_Homo sapiens_hsa046300.95736576
49Rheumatoid arthritis_Homo sapiens_hsa053230.90819012
50Measles_Homo sapiens_hsa051620.90364665
51Pancreatic cancer_Homo sapiens_hsa052120.90099209
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.89345718
53ErbB signaling pathway_Homo sapiens_hsa040120.88541435
54Endometrial cancer_Homo sapiens_hsa052130.88474157
55HIF-1 signaling pathway_Homo sapiens_hsa040660.85712522
56Insulin resistance_Homo sapiens_hsa049310.84893738
57Type I diabetes mellitus_Homo sapiens_hsa049400.84134551
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81686473
59Choline metabolism in cancer_Homo sapiens_hsa052310.80242649
60Notch signaling pathway_Homo sapiens_hsa043300.80048346
61MAPK signaling pathway_Homo sapiens_hsa040100.79326815
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79195042
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.79175529
64Dorso-ventral axis formation_Homo sapiens_hsa043200.78816816
65Shigellosis_Homo sapiens_hsa051310.77806671
66Insulin signaling pathway_Homo sapiens_hsa049100.77547084
67FoxO signaling pathway_Homo sapiens_hsa040680.77477827
68Estrogen signaling pathway_Homo sapiens_hsa049150.75781995
69Prostate cancer_Homo sapiens_hsa052150.75475102
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71980853
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71902362
72Long-term potentiation_Homo sapiens_hsa047200.70864136
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70802830
74Apoptosis_Homo sapiens_hsa042100.70281795
75Ovarian steroidogenesis_Homo sapiens_hsa049130.69786339
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69730534
77Lysosome_Homo sapiens_hsa041420.67544932
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67159246
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67049002
80Inositol phosphate metabolism_Homo sapiens_hsa005620.67021010
81Fatty acid biosynthesis_Homo sapiens_hsa000610.66463260
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66231954
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64467143
84Glioma_Homo sapiens_hsa052140.64378688
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.61522113
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.60703684
87Endocytosis_Homo sapiens_hsa041440.59831395
88Hematopoietic cell lineage_Homo sapiens_hsa046400.58074687
89Phagosome_Homo sapiens_hsa041450.57739071
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57716079
91Herpes simplex infection_Homo sapiens_hsa051680.57496063
92Proteoglycans in cancer_Homo sapiens_hsa052050.51798358
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50738566
94Platelet activation_Homo sapiens_hsa046110.50566855
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50514884
96Galactose metabolism_Homo sapiens_hsa000520.47670179
97Rap1 signaling pathway_Homo sapiens_hsa040150.47387933
98cAMP signaling pathway_Homo sapiens_hsa040240.46713250
99Bile secretion_Homo sapiens_hsa049760.46529204
100Focal adhesion_Homo sapiens_hsa045100.46159159

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