ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chromosome condensation (GO:0030261)	9.70355521
2	response to pheromone (GO:0019236)	9.63640686
3	DNA packaging (GO:0006323)	9.27921559
4	sperm capacitation (GO:0048240)	9.16308051
5	plasma membrane fusion (GO:0045026)	9.04582147
6	single strand break repair (GO:0000012)	8.44778879
7	spermatid nucleus differentiation (GO:0007289)	8.42388642
8	spermatid development (GO:0007286)	7.94645334
9	sperm-egg recognition (GO:0035036)	7.75994188
10	microtubule depolymerization (GO:0007019)	7.67417130
11	sexual reproduction (GO:0019953)	7.51593275
12	multicellular organism reproduction (GO:0032504)	7.30318828
13	binding of sperm to zona pellucida (GO:0007339)	7.14491998
14	reproduction (GO:0000003)	7.10217005
15	rRNA methylation (GO:0031167)	7.08498043
16	negative regulation of inclusion body assembly (GO:0090084)	6.58213688
17	microtubule polymerization or depolymerization (GO:0031109)	6.57103098
18	calcium ion-dependent exocytosis (GO:0017156)	6.46451586
19	protein targeting to Golgi (GO:0000042)	6.39314315
20	cell-cell recognition (GO:0009988)	6.37633763
21	protein polyglutamylation (GO:0018095)	6.35780250
22	axonemal dynein complex assembly (GO:0070286)	6.30903673
23	establishment of protein localization to Golgi (GO:0072600)	6.29977274
24	regulation of cilium movement (GO:0003352)	6.17609539
25	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	6.15151223
26	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.06312169
27	spermatogenesis (GO:0007283)	6.01012032
28	cellular ketone body metabolic process (GO:0046950)	6.00893920
29	male gamete generation (GO:0048232)	5.98897918
30	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.95934156
31	rRNA modification (GO:0000154)	5.90239784
32	phosphatidylethanolamine metabolic process (GO:0046337)	5.55151567
33	microtubule severing (GO:0051013)	5.52737785
34	gamete generation (GO:0007276)	5.45842815
35	ketone body metabolic process (GO:1902224)	5.40558610
36	chromatin silencing (GO:0006342)	5.32528332
37	motile cilium assembly (GO:0044458)	5.31907694
38	positive regulation of Rab GTPase activity (GO:0032851)	5.28305119
39	regulation of Rab GTPase activity (GO:0032313)	5.28305119
40	single fertilization (GO:0007338)	5.01096298
41	centriole replication (GO:0007099)	4.91783933
42	cilium or flagellum-dependent cell motility (GO:0001539)	4.88262086
43	regulation of inclusion body assembly (GO:0090083)	4.70304115
44	protein localization to Golgi apparatus (GO:0034067)	4.63741898
45	RNA destabilization (GO:0050779)	4.60680286
46	germ cell development (GO:0007281)	4.48425003
47	centriole assembly (GO:0098534)	4.42097498
48	multicellular organismal reproductive process (GO:0048609)	4.36401107
49	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.34533872
50	coenzyme catabolic process (GO:0009109)	4.22440837
51	cell wall macromolecule catabolic process (GO:0016998)	4.13923893
52	fertilization (GO:0009566)	4.08554223
53	nucleus organization (GO:0006997)	4.06968875
54	cell wall macromolecule metabolic process (GO:0044036)	4.04509051
55	regulation of centriole replication (GO:0046599)	4.04092248
56	regulation of transcription involved in cell fate commitment (GO:0060850)	4.02574426
57	epithelial cilium movement (GO:0003351)	3.92210732
58	regulation of microtubule-based movement (GO:0060632)	3.86235642
59	seminiferous tubule development (GO:0072520)	3.85756246
60	glycerol ether metabolic process (GO:0006662)	3.74522837
61	negative regulation of Rho protein signal transduction (GO:0035024)	3.65651905
62	negative regulation of gene expression, epigenetic (GO:0045814)	3.58736096
63	cilium movement (GO:0003341)	3.49961226
64	glomerular visceral epithelial cell development (GO:0072015)	3.47522859
65	ether metabolic process (GO:0018904)	3.45464533
66	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.44173471
67	musculoskeletal movement (GO:0050881)	3.43222424
68	multicellular organismal movement (GO:0050879)	3.43222424
69	cellular response to pH (GO:0071467)	3.42129093
70	nucleosome disassembly (GO:0006337)	3.36030242
71	protein-DNA complex disassembly (GO:0032986)	3.36030242
72	glomerular epithelial cell development (GO:0072310)	3.35905029
73	organic cation transport (GO:0015695)	3.35538774
74	response to acidic pH (GO:0010447)	3.32085215
75	histone H3-K9 demethylation (GO:0033169)	3.24205414
76	regulation of interleukin-13 production (GO:0032656)	3.22543363
77	cerebral cortex neuron differentiation (GO:0021895)	3.21419699
78	peptidyl-threonine dephosphorylation (GO:0035970)	3.20569439
79	homeostasis of number of cells within a tissue (GO:0048873)	3.18301352
80	DNA conformation change (GO:0071103)	3.08740903
81	cell recognition (GO:0008037)	3.06768091
82	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.03474660
83	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.03474660
84	membrane protein intracellular domain proteolysis (GO:0031293)	3.00201282
85	regulation of T-helper 2 cell differentiation (GO:0045628)	2.98489217
86	polyamine biosynthetic process (GO:0006596)	2.92735678
87	multicellular organismal development (GO:0007275)	2.92148523
88	cell differentiation involved in metanephros development (GO:0072202)	2.89487764
89	NAD biosynthetic process (GO:0009435)	2.89160367
90	positive regulation of endothelial cell differentiation (GO:0045603)	2.88855928
91	protein depolymerization (GO:0051261)	2.87637982
92	peptide catabolic process (GO:0043171)	2.87024140
93	receptor recycling (GO:0001881)	2.84091343
94	peptidyl-proline hydroxylation (GO:0019511)	2.81341266
95	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.79430181
96	microtubule nucleation (GO:0007020)	2.71760329
97	positive regulation of skeletal muscle tissue development (GO:0048643)	2.68562999
98	acrosome reaction (GO:0007340)	12.1838880
99	fusion of sperm to egg plasma membrane (GO:0007342)	11.9267124
100	sperm motility (GO:0030317)	11.6497050

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.12201791
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.86103744
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.80941257
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.40648849
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40648849
6	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.25189085
7	ERA_21632823_ChIP-Seq_H3396_Human	2.14821005
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.09872247
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.07760932
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.98107404
11	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.95263375
12	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.94283770
13	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.89563743
14	* CBP_20019798_ChIP-Seq_JUKART_Human	1.89563743
15	RAC3_21632823_ChIP-Seq_H3396_Human	1.88745306
16	* EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.85598517
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.79931958
18	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.78835664
19	BCOR_27268052_Chip-Seq_Bcells_Human	1.78216346
20	E2F1_20622854_ChIP-Seq_HELA_Human	1.76635187
21	DROSHA_22980978_ChIP-Seq_HELA_Human	1.75511040
22	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.75182843
23	FUS_26573619_Chip-Seq_HEK293_Human	1.74682464
24	BCL6_27268052_Chip-Seq_Bcells_Human	1.74186143
25	MYC_19829295_ChIP-Seq_ESCs_Human	1.73709157
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73558399
27	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.72353451
28	P68_20966046_ChIP-Seq_HELA_Human	1.70545073
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.70348490
30	PHF8_20622854_ChIP-Seq_HELA_Human	1.67696589
31	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.65883730
32	CTCF_20526341_ChIP-Seq_ESCs_Human	1.63391608
33	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.61415681
34	SMC4_20622854_ChIP-Seq_HELA_Human	1.60199956
35	OCT4_20526341_ChIP-Seq_ESCs_Human	1.59882841
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.58825705
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.58300603
38	TP63_22573176_ChIP-Seq_HFKS_Human	1.58153357
39	TAF2_19829295_ChIP-Seq_ESCs_Human	1.58111037
40	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.57667864
41	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.48328914
42	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.44594726
43	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.44100255
44	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.44041483
45	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.43589901
46	LXR_22292898_ChIP-Seq_THP-1_Human	1.40615054
47	P300_27268052_Chip-Seq_Bcells_Human	1.40039915
48	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.39524744
49	TP53_18474530_ChIP-ChIP_U2OS_Human	1.37646368
50	* ER_23166858_ChIP-Seq_MCF-7_Human	1.37304742
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.37259217
52	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37207540
53	ERG_20517297_ChIP-Seq_VCAP_Human	1.36037350
54	RBPJ_21746931_ChIP-Seq_IB4_Human	1.35991518
55	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.35865421
56	AR_25329375_ChIP-Seq_VCAP_Human	1.35833725
57	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.35585782
58	EZH2_22144423_ChIP-Seq_EOC_Human	1.34565411
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.33994629
60	CEBPB_22108803_ChIP-Seq_LS180_Human	1.33485889
61	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.29109056
62	ETV1_20927104_ChIP-Seq_GIST48_Human	1.28594469
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.28012894
64	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24614219
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.24465937
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.21774310
67	SA1_27219007_Chip-Seq_Bcells_Human	1.20327825
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.19785965
69	* SMAD3_21741376_ChIP-Seq_ESCs_Human	1.19048809
70	SMRT_27268052_Chip-Seq_Bcells_Human	1.18602930
71	NFYB_21822215_ChIP-Seq_K562_Human	1.17034145
72	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.16651542
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16319519
74	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.15811590
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15410473
76	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.15102159
77	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14397887
78	P300_19829295_ChIP-Seq_ESCs_Human	1.13884343
79	TBL1_22424771_ChIP-Seq_293T_Human	1.13822288
80	PHF8_20622853_ChIP-Seq_HELA_Human	1.12776276
81	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.11009652
82	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.09782252
83	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.06941384
84	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06160603
85	TAF15_26573619_Chip-Seq_HEK293_Human	1.06131968
86	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05835768
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05835768
88	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.05377824
89	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.04823350
90	ZNF274_21170338_ChIP-Seq_K562_Hela	1.04629728
91	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04364597
92	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04264219
93	NFYA_21822215_ChIP-Seq_K562_Human	1.04074719
94	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03365385
95	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.02417772
96	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.01939698
97	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00885756
98	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00772268
99	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.99835825
100	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.97097655

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.11408829
2	MP0005377_hearing/vestibular/ear_phenot	5.11408829
3	MP0003698_abnormal_male_reproductive	4.40153374
4	MP0005670_abnormal_white_adipose	4.38355559
5	MP0001348_abnormal_lacrimal_gland	3.82936552
6	MP0001929_abnormal_gametogenesis	3.72850492
7	MP0003646_muscle_fatigue	2.55144444
8	MP0000678_abnormal_parathyroid_gland	2.51586990
9	MP0002161_abnormal_fertility/fecundity	2.40035079
10	MP0003011_delayed_dark_adaptation	2.27829130
11	MP0002132_abnormal_respiratory_system	2.12092179
12	MP0003718_maternal_effect	2.02536555
13	MP0005410_abnormal_fertilization	12.6671379
14	MP0005379_endocrine/exocrine_gland_phen	1.78623565
15	MP0002234_abnormal_pharynx_morphology	1.60732149
16	MP0005310_abnormal_salivary_gland	1.56756107
17	MP0004510_myositis	1.50383400
18	MP0002210_abnormal_sex_determination	1.50065354
19	MP0001968_abnormal_touch/_nociception	1.47008911
20	MP0002249_abnormal_larynx_morphology	1.44855441
21	MP0009053_abnormal_anal_canal	1.39946564
22	MP0002282_abnormal_trachea_morphology	1.39325108
23	MP0001765_abnormal_ion_homeostasis	1.32309690
24	MP0003879_abnormal_hair_cell	1.30207202
25	MP0002653_abnormal_ependyma_morphology	1.29440086
26	MP0001485_abnormal_pinna_reflex	1.29388087
27	MP0005423_abnormal_somatic_nervous	1.26564839
28	MP0001486_abnormal_startle_reflex	1.23066351
29	MP0001145_abnormal_male_reproductive	1.21058523
30	MP0002735_abnormal_chemical_nociception	1.19205313
31	MP0002138_abnormal_hepatobiliary_system	1.15394540
32	MP0000534_abnormal_ureter_morphology	1.15037599
33	MP0002127_abnormal_cardiovascular_syste	1.14563339
34	MP0000653_abnormal_sex_gland	1.11860753
35	MP0005248_abnormal_Harderian_gland	1.11669006
36	MP0001963_abnormal_hearing_physiology	1.08498657
37	MP0004264_abnormal_extraembryonic_tissu	1.01877814
38	MP0004742_abnormal_vestibular_system	1.00616456
39	MP0000026_abnormal_inner_ear	0.97749547
40	MP0005395_other_phenotype	0.95706360
41	MP0002229_neurodegeneration	0.93355506
42	MP0004859_abnormal_synaptic_plasticity	0.87271591
43	MP0005167_abnormal_blood-brain_barrier	0.87234930
44	MP0005666_abnormal_adipose_tissue	0.84370687
45	MP0005551_abnormal_eye_electrophysiolog	0.82556283
46	MP0005375_adipose_tissue_phenotype	0.81284285
47	MP0004233_abnormal_muscle_weight	0.80644346
48	MP0000681_abnormal_thyroid_gland	0.80451863
49	MP0000003_abnormal_adipose_tissue	0.79254801
50	MP0009697_abnormal_copulation	0.78668905
51	MP0002822_catalepsy	0.75242749
52	MP0001666_abnormal_nutrient_absorption	0.74795830
53	MP0005451_abnormal_body_composition	0.74698601
54	MP0009115_abnormal_fat_cell	0.74105074
55	MP0008877_abnormal_DNA_methylation	0.72676181
56	MP0000955_abnormal_spinal_cord	0.71893689
57	MP0002067_abnormal_sensory_capabilities	0.66692350
58	MP0005636_abnormal_mineral_homeostasis	0.66431489
59	MP0005253_abnormal_eye_physiology	0.64992358
60	MP0004085_abnormal_heartbeat	0.64371568
61	MP0005408_hypopigmentation	0.63405207
62	MP0000049_abnormal_middle_ear	0.63122603
63	MP0010386_abnormal_urinary_bladder	0.59857120
64	MP0002733_abnormal_thermal_nociception	0.59320858
65	MP0008569_lethality_at_weaning	0.58473093
66	MP0003638_abnormal_response/metabolism_	0.57046241
67	MP0004036_abnormal_muscle_relaxation	0.57019362
68	MP0004484_altered_response_of	0.56911340
69	MP0001879_abnormal_lymphatic_vessel	0.56282838
70	MP0002736_abnormal_nociception_after	0.55675429
71	MP0000249_abnormal_blood_vessel	0.55662100
72	MP0001984_abnormal_olfaction	0.53635352
73	MP0001905_abnormal_dopamine_level	0.52999345
74	MP0005535_abnormal_body_temperature	0.51177748
75	MP0005083_abnormal_biliary_tract	0.51112890
76	MP0000371_diluted_coat_color	0.50639640
77	MP0010329_abnormal_lipoprotein_level	0.48914149
78	MP0000516_abnormal_urinary_system	0.47950163
79	MP0005367_renal/urinary_system_phenotyp	0.47950163
80	MP0000467_abnormal_esophagus_morphology	0.47407009
81	MP0002572_abnormal_emotion/affect_behav	0.45916986
82	MP0005332_abnormal_amino_acid	0.40782737
83	MP0001501_abnormal_sleep_pattern	0.39313164
84	MP0005365_abnormal_bile_salt	0.39202260
85	MP0002272_abnormal_nervous_system	0.39186343
86	MP0002557_abnormal_social/conspecific_i	0.39044616
87	MP0006292_abnormal_olfactory_placode	0.38526407
88	MP0003632_abnormal_nervous_system	0.38329718
89	MP0001970_abnormal_pain_threshold	0.38230694
90	MP0009745_abnormal_behavioral_response	0.37615501
91	MP0003329_amyloid_beta_deposits	0.36647007
92	MP0003077_abnormal_cell_cycle	0.36332103
93	MP0002734_abnormal_mechanical_nocicepti	0.35653769
94	MP0008775_abnormal_heart_ventricle	0.35089700
95	MP0000230_abnormal_systemic_arterial	0.33346939
96	MP0005391_vision/eye_phenotype	0.33100854
97	MP0005595_abnormal_vascular_smooth	0.32189448
98	MP0008995_early_reproductive_senescence	0.31902253
99	MP0009764_decreased_sensitivity_to	0.31755744
100	MP0008789_abnormal_olfactory_epithelium	0.31536025

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	8.61007282
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.42777893
3	Absent/shortened dynein arms (HP:0200106)	6.42777893
4	Asymmetric septal hypertrophy (HP:0001670)	5.72556966
5	Attenuation of retinal blood vessels (HP:0007843)	5.56080468
6	Male infertility (HP:0003251)	5.14214389
7	Bony spicule pigmentary retinopathy (HP:0007737)	5.10458939
8	Abnormal ciliary motility (HP:0012262)	5.01304771
9	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.91442684
10	Abnormal respiratory motile cilium morphology (HP:0005938)	4.77944114
11	Abnormal respiratory epithelium morphology (HP:0012253)	4.77944114
12	Tubulointerstitial nephritis (HP:0001970)	4.73013557
13	Abnormal respiratory motile cilium physiology (HP:0012261)	4.69457110
14	Nasal polyposis (HP:0100582)	4.57472124
15	Infertility (HP:0000789)	4.43130879
16	Abnormal rod and cone electroretinograms (HP:0008323)	4.21311723
17	Hypoplastic ischia (HP:0003175)	4.11913224
18	Resting tremor (HP:0002322)	4.11392826
19	Abnormality of macular pigmentation (HP:0008002)	4.08258392
20	Abnormal spermatogenesis (HP:0008669)	4.06368231
21	Hyperkalemia (HP:0002153)	4.03504695
22	Chronic hepatic failure (HP:0100626)	3.99090059
23	Bell-shaped thorax (HP:0001591)	3.95612392
24	Potter facies (HP:0002009)	3.90698313
25	Facial shape deformation (HP:0011334)	3.90698313
26	Abnormality of the ischium (HP:0003174)	3.83809775
27	Abnormality of the nasal mucosa (HP:0000433)	3.76387831
28	Enlarged epiphyses (HP:0010580)	3.72129208
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.68137931
30	Azoospermia (HP:0000027)	3.47071741
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.38201933
32	Cone-rod dystrophy (HP:0000548)	3.37980036
33	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.05007048
34	Stage 5 chronic kidney disease (HP:0003774)	2.96385411
35	Impulsivity (HP:0100710)	2.81260319
36	Progressive sensorineural hearing impairment (HP:0000408)	2.81209612
37	Nephronophthisis (HP:0000090)	2.80223185
38	Postural instability (HP:0002172)	2.74090855
39	Hypoplasia of the thymus (HP:0000778)	2.73425860
40	Unilateral renal agenesis (HP:0000122)	2.72889212
41	Abnormal urine output (HP:0012590)	2.70435906
42	Rhinitis (HP:0012384)	2.69408156
43	Hypoalphalipoproteinemia (HP:0003233)	2.64043858
44	Double outlet right ventricle (HP:0001719)	2.63147674
45	Congenital malformation of the right heart (HP:0011723)	2.63147674
46	Generalized aminoaciduria (HP:0002909)	2.61476279
47	Amelogenesis imperfecta (HP:0000705)	2.57090302
48	Abnormality of the aortic arch (HP:0012303)	2.56665814
49	Renal dysplasia (HP:0000110)	2.54322875
50	Abnormality of dental color (HP:0011073)	2.48021616
51	Portal hypertension (HP:0001409)	2.38912504
52	Abnormality of potassium homeostasis (HP:0011042)	2.37892425
53	Truncal obesity (HP:0001956)	2.34066124
54	Abnormality of renal excretion (HP:0011036)	2.33067503
55	Progressive cerebellar ataxia (HP:0002073)	2.31938242
56	Abnormality of the renal medulla (HP:0100957)	2.30502531
57	Tubulointerstitial abnormality (HP:0001969)	2.23407307
58	Menstrual irregularities (HP:0000858)	2.22925576
59	Bronchiectasis (HP:0002110)	2.17721772
60	Abnormality of the costochondral junction (HP:0000919)	2.17363389
61	Abnormality of the hepatic vasculature (HP:0006707)	2.17088471
62	Abnormal drinking behavior (HP:0030082)	2.15096627
63	Polydipsia (HP:0001959)	2.15096627
64	Insulin-resistant diabetes mellitus (HP:0000831)	2.13445048
65	Focal segmental glomerulosclerosis (HP:0000097)	2.12750729
66	Polyuria (HP:0000103)	2.10812341
67	Abnormality of the parathyroid morphology (HP:0011766)	2.10555960
68	Neoplasm of the heart (HP:0100544)	2.10366807
69	Ventricular tachycardia (HP:0004756)	2.10219616
70	Failure to thrive in infancy (HP:0001531)	2.07811019
71	Osteomalacia (HP:0002749)	2.03140572
72	Flattened epiphyses (HP:0003071)	2.01672395
73	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.99202330
74	Absent epiphyses (HP:0010577)	1.99202330
75	Hypophosphatemic rickets (HP:0004912)	1.96960789
76	Spastic paraparesis (HP:0002313)	1.95749827
77	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.95662665
78	Hyponatremia (HP:0002902)	1.95496087
79	Optic nerve hypoplasia (HP:0000609)	1.90917327
80	Epiphyseal dysplasia (HP:0002656)	1.90002405
81	Recurrent pneumonia (HP:0006532)	1.89561143
82	Renovascular hypertension (HP:0100817)	1.89360410
83	Widely patent fontanelles and sutures (HP:0004492)	1.86809976
84	Abnormality of the pubic bones (HP:0003172)	1.85426570
85	Abnormality of femoral epiphyses (HP:0006499)	1.84202083
86	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.84202083
87	Abnormal ventriculo-arterial connection (HP:0011563)	1.81715277
88	Transposition of the great arteries (HP:0001669)	1.81715277
89	Abnormal connection of the cardiac segments (HP:0011545)	1.81715277
90	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.78060575
91	Glucose intolerance (HP:0000833)	1.76803254
92	Intellectual disability, moderate (HP:0002342)	1.76219742
93	Progressive hearing impairment (HP:0001730)	1.73329141
94	Decreased central vision (HP:0007663)	1.73247245
95	Bradycardia (HP:0001662)	1.72815733
96	Chronic bronchitis (HP:0004469)	1.72506927
97	Abnormality of the femoral head (HP:0003368)	1.72110854
98	Photophobia (HP:0000613)	1.72088831
99	Tubular atrophy (HP:0000092)	1.71621316
100	Glomerulosclerosis (HP:0000096)	1.70889908

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	7.60044333
2	TESK1	5.92009326
3	MAP4K2	4.63231214
4	TAOK3	4.54881158
5	DDR2	4.39635015
6	BRD4	3.74558104
7	INSRR	3.37269586
8	STK38	3.06042596
9	PLK2	3.02209797
10	PRKD3	2.12312463
11	PNCK	2.05107117
12	DYRK1B	1.84817643
13	MAPK15	1.84484324
14	CDK12	1.80933538
15	CAMK1G	1.77693330
16	WNK1	1.70703916
17	MST1R	1.69212324
18	STK38L	1.60934516
19	PDPK1	1.53018481
20	PDK1	1.49502608
21	PIK3CG	1.47569309
22	NEK6	1.42296021
23	PTK2B	1.25735858
24	CDK7	1.21954363
25	MAP3K11	0.97566638
26	MAP3K9	0.95312746
27	KSR2	0.94383086
28	TESK2	0.87952461
29	MAP2K2	0.87904323
30	PRKAA2	0.87551635
31	LATS2	0.77658798
32	EIF2AK1	0.76027471
33	CDK3	0.75999421
34	AKT3	0.74187402
35	ADRBK2	0.71040654
36	SIK2	0.70888417
37	MARK2	0.69930736
38	RPS6KA2	0.69192602
39	PRKG2	0.68998162
40	MAP3K7	0.65019016
41	CAMK1	0.62322466
42	CAMK1D	0.60559609
43	BRAF	0.56114900
44	PKN1	0.55696955
45	WNK4	0.55245081
46	CAMK4	0.55145347
47	PRKG1	0.54916851
48	JAK3	0.52848982
49	MUSK	0.52562428
50	RPS6KA1	0.51541829
51	TYRO3	0.50906843
52	UHMK1	0.46385806
53	CDK19	0.44676333
54	KIT	0.44085571
55	ARAF	0.43607508
56	ACVR1B	0.42573832
57	MARK3	0.40879758
58	ROCK1	0.40145847
59	MAP3K8	0.38329929
60	MAPK11	0.37625077
61	MTOR	0.37161433
62	BMPR1B	0.35978364
63	PRKD2	0.35125791
64	MAPK1	0.34228677
65	PINK1	0.33138974
66	PRKCZ	0.32638741
67	FRK	0.32204765
68	GSK3B	0.32030033
69	TIE1	0.29610732
70	MAP3K1	0.27877602
71	CDK2	0.27518640
72	FGR	0.26882947
73	CDK4	0.26348247
74	RPS6KL1	0.23930258
75	RPS6KC1	0.23930258
76	CDK1	0.23679268
77	MAP3K2	0.22229302
78	RPS6KA6	0.21929551
79	STK39	0.21593175
80	MAPK8	0.21575332
81	MET	0.20544582
82	FER	0.20076585
83	IKBKB	0.19486438
84	PRKACB	0.17776346
85	PRKAA1	0.17460843
86	SGK223	0.15192364
87	SGK494	0.15192364
88	LATS1	0.14710202
89	MAP2K1	0.14295124
90	PRKCB	0.14239713
91	MAPK10	0.14176789
92	TRPM7	0.13925478
93	MAPK14	0.13253841
94	PRKCG	0.12109949
95	SGK1	0.11875603
96	AKT1	0.10063803
97	BRSK1	0.09951403
98	MAP3K13	0.09588533
99	MATK	0.09564532
100	BRSK2	0.08248461

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.01456756
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	5.43682757
3	Olfactory transduction_Homo sapiens_hsa04740	3.35853483
4	Butanoate metabolism_Homo sapiens_hsa00650	2.69049288
5	Glycerophospholipid metabolism_Homo sapiens_hsa00564	2.29408898
6	Allograft rejection_Homo sapiens_hsa05330	1.92931874
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.88555792
8	Graft-versus-host disease_Homo sapiens_hsa05332	1.87998691
9	Antigen processing and presentation_Homo sapiens_hsa04612	1.82234316
10	Type I diabetes mellitus_Homo sapiens_hsa04940	1.75693892
11	Fatty acid degradation_Homo sapiens_hsa00071	1.68503959
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.58850669
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.58404514
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.42072485
15	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.40459481
16	Taste transduction_Homo sapiens_hsa04742	1.40313569
17	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.39437984
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.35014085
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.34204156
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.27186478
21	Fatty acid metabolism_Homo sapiens_hsa01212	1.27003437
22	Viral myocarditis_Homo sapiens_hsa05416	1.25773018
23	Protein digestion and absorption_Homo sapiens_hsa04974	1.23784063
24	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.22876606
25	Arginine and proline metabolism_Homo sapiens_hsa00330	1.22769727
26	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.19851222
27	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19451417
28	Phototransduction_Homo sapiens_hsa04744	1.17175385
29	Glycerolipid metabolism_Homo sapiens_hsa00561	1.14848613
30	PPAR signaling pathway_Homo sapiens_hsa03320	1.14003788
31	Endocytosis_Homo sapiens_hsa04144	1.12929770
32	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.08042328
33	Renin-angiotensin system_Homo sapiens_hsa04614	1.05848433
34	RNA transport_Homo sapiens_hsa03013	1.00778812
35	Retinol metabolism_Homo sapiens_hsa00830	1.00763571
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00007823
37	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.96674567
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93648031
39	Salivary secretion_Homo sapiens_hsa04970	0.93181185
40	Tyrosine metabolism_Homo sapiens_hsa00350	0.92201917
41	Influenza A_Homo sapiens_hsa05164	0.87875291
42	ABC transporters_Homo sapiens_hsa02010	0.85181496
43	Acute myeloid leukemia_Homo sapiens_hsa05221	0.81271087
44	Basal transcription factors_Homo sapiens_hsa03022	0.77929535
45	Bile secretion_Homo sapiens_hsa04976	0.77073508
46	Pancreatic secretion_Homo sapiens_hsa04972	0.76547383
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74209026
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.73532124
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.71996258
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69186922
51	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.68606095
52	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66358004
53	Calcium signaling pathway_Homo sapiens_hsa04020	0.65970194
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62223502
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.61741048
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56954978
57	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56892136
58	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.55315361
59	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.55163349
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54246054
61	Morphine addiction_Homo sapiens_hsa05032	0.54175611
62	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52871390
63	Linoleic acid metabolism_Homo sapiens_hsa00591	0.52456353
64	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.52105518
65	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51654254
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45952021
67	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.43612911
68	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.42094088
69	Oocyte meiosis_Homo sapiens_hsa04114	0.41346274
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.38717243
71	Circadian entrainment_Homo sapiens_hsa04713	0.38120041
72	Tryptophan metabolism_Homo sapiens_hsa00380	0.38107099
73	Insulin secretion_Homo sapiens_hsa04911	0.37940084
74	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36161401
75	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.33747641
76	Purine metabolism_Homo sapiens_hsa00230	0.32760377
77	VEGF signaling pathway_Homo sapiens_hsa04370	0.32366711
78	Nicotine addiction_Homo sapiens_hsa05033	0.31866653
79	Glutamatergic synapse_Homo sapiens_hsa04724	0.30954786
80	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.30445001
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29770607
82	Gastric acid secretion_Homo sapiens_hsa04971	0.28832993
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.28763591
84	Caffeine metabolism_Homo sapiens_hsa00232	0.27447838
85	Renin secretion_Homo sapiens_hsa04924	0.27289962
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.26776693
87	Herpes simplex infection_Homo sapiens_hsa05168	0.25618004
88	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.25494839
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.24944083
90	Choline metabolism in cancer_Homo sapiens_hsa05231	0.23990015
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.23383089
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.22944303
93	Regulation of autophagy_Homo sapiens_hsa04140	0.22829810
94	Tight junction_Homo sapiens_hsa04530	0.22782834
95	Metabolic pathways_Homo sapiens_hsa01100	0.22330641
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.22154198
97	Peroxisome_Homo sapiens_hsa04146	0.21912685
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.21576395
99	Serotonergic synapse_Homo sapiens_hsa04726	0.21518885
100	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21293743

C17ORF47

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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