C17ORF49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.38107240
2DNA deamination (GO:0045006)5.20530583
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.20406755
4ATP synthesis coupled proton transport (GO:0015986)5.20406755
5ribosomal small subunit assembly (GO:0000028)4.84537488
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.70140050
7viral transcription (GO:0019083)4.59081450
8cytidine metabolic process (GO:0046087)4.38134874
9cytidine catabolic process (GO:0006216)4.38134874
10cytidine deamination (GO:0009972)4.38134874
11translational termination (GO:0006415)4.30890489
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30770926
13protein neddylation (GO:0045116)4.29680660
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.20594654
15chaperone-mediated protein transport (GO:0072321)4.12328079
16respiratory electron transport chain (GO:0022904)4.11805315
17protein complex biogenesis (GO:0070271)4.06002507
18electron transport chain (GO:0022900)4.05762986
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.02584522
20protein targeting to ER (GO:0045047)3.97532431
21cotranslational protein targeting to membrane (GO:0006613)3.96313207
22sequestering of actin monomers (GO:0042989)3.90953980
23translational elongation (GO:0006414)3.85152309
24protein localization to endoplasmic reticulum (GO:0070972)3.79787244
25ribosomal small subunit biogenesis (GO:0042274)3.79591614
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.76677186
27pyrimidine ribonucleoside catabolic process (GO:0046133)3.74599526
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.72235878
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.68471647
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.68471647
31NADH dehydrogenase complex assembly (GO:0010257)3.68471647
32tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67365174
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67365174
34mitochondrial respiratory chain complex assembly (GO:0033108)3.60958339
35viral life cycle (GO:0019058)3.60672760
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.39582768
37negative regulation of telomere maintenance (GO:0032205)3.35854741
38cellular protein complex disassembly (GO:0043624)3.26370458
39response to interferon-beta (GO:0035456)3.19637067
40purine deoxyribonucleotide catabolic process (GO:0009155)3.18041291
41deoxyribonucleotide catabolic process (GO:0009264)3.17382875
42maturation of SSU-rRNA (GO:0030490)3.15174337
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10212256
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09087890
45purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.08281355
46immunoglobulin mediated immune response (GO:0016064)3.05366773
47platelet dense granule organization (GO:0060155)3.04663986
48DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00629314
49proteasome assembly (GO:0043248)3.00542099
50cellular response to interferon-beta (GO:0035458)2.98870206
51deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.97794824
52cytochrome complex assembly (GO:0017004)2.97694790
53translational initiation (GO:0006413)2.97053195
54deoxyribose phosphate catabolic process (GO:0046386)2.96324222
55ATP biosynthetic process (GO:0006754)2.93306415
56Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92852760
57regulation of cellular amino acid metabolic process (GO:0006521)2.91213542
58iron-sulfur cluster assembly (GO:0016226)2.90747343
59metallo-sulfur cluster assembly (GO:0031163)2.90747343
60hydrogen ion transmembrane transport (GO:1902600)2.88163820
61translation (GO:0006412)2.86214327
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.84881690
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.84881690
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84227495
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84227495
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84227495
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.84114462
68negative regulation of B cell apoptotic process (GO:0002903)2.80141441
69positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.80063728
70pyrimidine nucleotide catabolic process (GO:0006244)2.79938171
71T cell migration (GO:0072678)2.79651129
72purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.79420789
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78686024
74protein complex disassembly (GO:0043241)2.77563102
75purine nucleoside triphosphate biosynthetic process (GO:0009145)2.76895878
76negative regulation of ligase activity (GO:0051352)2.76243077
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.76243077
78inner mitochondrial membrane organization (GO:0007007)2.74701803
79viral protein processing (GO:0019082)2.73021575
80termination of RNA polymerase III transcription (GO:0006386)2.72556376
81transcription elongation from RNA polymerase III promoter (GO:0006385)2.72556376
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72304251
83pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.68775338
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.68485510
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.68282085
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67960888
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.66882168
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.66882168
89macromolecular complex disassembly (GO:0032984)2.65490050
902-deoxyribonucleotide metabolic process (GO:0009394)2.64609963
91establishment of protein localization to mitochondrion (GO:0072655)2.64310534
92NIK/NF-kappaB signaling (GO:0038061)2.63328407
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63036029
94proton transport (GO:0015992)2.63006838
95respiratory chain complex IV assembly (GO:0008535)2.62636027
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62285932
97positive regulation of defense response to virus by host (GO:0002230)2.62017545
98protein targeting to mitochondrion (GO:0006626)2.61791785
99purine deoxyribonucleotide metabolic process (GO:0009151)2.61225596
100negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.59952487

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.93356458
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.76608223
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55008774
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.42639212
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.40055223
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.38595399
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30744688
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29888062
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10028817
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92595990
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.83858345
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71737947
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.69393478
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.42987168
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39138548
16* VDR_23849224_ChIP-Seq_CD4+_Human2.34735536
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29870934
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.18818875
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.16369240
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16072660
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12458721
22FOXP3_21729870_ChIP-Seq_TREG_Human2.11456051
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06141772
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04339060
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.01391800
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01359836
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.93680757
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.88921640
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88182251
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74870138
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71020390
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.69070519
33GABP_19822575_ChIP-Seq_HepG2_Human1.68960111
34CIITA_25753668_ChIP-Seq_RAJI_Human1.67172435
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65528989
36XRN2_22483619_ChIP-Seq_HELA_Human1.60321551
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58654979
38EZH2_22144423_ChIP-Seq_EOC_Human1.57475829
39BCL6_27268052_Chip-Seq_Bcells_Human1.54562399
40ELK1_19687146_ChIP-ChIP_HELA_Human1.54435144
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54017600
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52492539
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.49283194
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49148626
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45687509
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41048153
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39617777
48TTF2_22483619_ChIP-Seq_HELA_Human1.39338572
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38001594
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37782057
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.33504273
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33246939
53* SPI1_23547873_ChIP-Seq_NB4_Human1.31470456
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31002153
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30389122
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29795217
57MYC_18940864_ChIP-ChIP_HL60_Human1.29745262
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28943000
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28118885
60YY1_22570637_ChIP-Seq_MALME-3M_Human1.25322999
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25077600
62MAF_26560356_Chip-Seq_TH2_Human1.21926226
63DCP1A_22483619_ChIP-Seq_HELA_Human1.20301052
64* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17427368
65* MYB_26560356_Chip-Seq_TH2_Human1.16961465
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15092834
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14734979
68UTX_26944678_Chip-Seq_JUKART_Human1.14456251
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14096979
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11852417
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09718396
72FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08814205
73ZNF274_21170338_ChIP-Seq_K562_Hela1.07224445
74BCOR_27268052_Chip-Seq_Bcells_Human1.06539040
75IRF1_19129219_ChIP-ChIP_H3396_Human1.05830397
76VDR_21846776_ChIP-Seq_THP-1_Human1.05802423
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04963861
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04607213
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03234435
80P300_27268052_Chip-Seq_Bcells_Human1.01295031
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.99981579
82CTCF_26484167_Chip-Seq_Bcells_Mouse0.99562693
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99433571
84NANOG_20526341_ChIP-Seq_ESCs_Human0.99121003
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98892347
86E2F1_20622854_ChIP-Seq_HELA_Human0.97761553
87CTCF_20526341_ChIP-Seq_ESCs_Human0.97000670
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96697433
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95374397
90FOXP1_21924763_ChIP-Seq_HESCs_Human0.93435974
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93259300
92SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92600328
93* MAF_26560356_Chip-Seq_TH1_Human0.92318845
94GATA3_26560356_Chip-Seq_TH2_Human0.92263275
95IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92168778
96STAT1_20625510_ChIP-Seq_HELA_Human0.92084045
97PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91910746
98TP53_22573176_ChIP-Seq_HFKS_Human0.90975754
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90959536
100PHF8_20622854_ChIP-Seq_HELA_Human0.90954851

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.93451114
2MP0001835_abnormal_antigen_presentation2.68687881
3MP0009379_abnormal_foot_pigmentation2.65325050
4MP0002148_abnormal_hypersensitivity_rea2.57517977
5MP0009785_altered_susceptibility_to2.53809868
6MP0002653_abnormal_ependyma_morphology2.51317049
7MP0001800_abnormal_humoral_immune2.32128646
8MP0005387_immune_system_phenotype2.27607382
9MP0001790_abnormal_immune_system2.27607382
10MP0005084_abnormal_gallbladder_morpholo2.26073485
11MP0005000_abnormal_immune_tolerance2.22770683
12MP0002723_abnormal_immune_serum2.11448257
13MP0005025_abnormal_response_to2.09953311
14MP0006292_abnormal_olfactory_placode2.07496754
15MP0000685_abnormal_immune_system1.99888204
16MP0002420_abnormal_adaptive_immunity1.97550774
17MP0001819_abnormal_immune_cell1.94256948
18MP0009333_abnormal_splenocyte_physiolog1.93167199
19MP0002138_abnormal_hepatobiliary_system1.88966787
20MP0006082_CNS_inflammation1.88891916
21MP0003436_decreased_susceptibility_to1.88853588
22MP0002452_abnormal_antigen_presenting1.87813706
23MP0008789_abnormal_olfactory_epithelium1.87222263
24MP0002277_abnormal_respiratory_mucosa1.84970690
25MP0003806_abnormal_nucleotide_metabolis1.80831326
26MP0003763_abnormal_thymus_physiology1.80018671
27MP0000372_irregular_coat_pigmentation1.73379101
28MP0004142_abnormal_muscle_tone1.72805957
29MP0002163_abnormal_gland_morphology1.62097267
30MP0003724_increased_susceptibility_to1.59875254
31MP0003011_delayed_dark_adaptation1.59450035
32MP0005075_abnormal_melanosome_morpholog1.57207015
33MP0002398_abnormal_bone_marrow1.57134896
34MP0000716_abnormal_immune_system1.54995272
35MP0002419_abnormal_innate_immunity1.54624807
36MP0005394_taste/olfaction_phenotype1.54437071
37MP0005499_abnormal_olfactory_system1.54437071
38MP0008995_early_reproductive_senescence1.53021552
39MP0001905_abnormal_dopamine_level1.52101729
40MP0005645_abnormal_hypothalamus_physiol1.49503862
41MP0008877_abnormal_DNA_methylation1.49386811
42MP0002405_respiratory_system_inflammati1.45980989
43MP0000689_abnormal_spleen_morphology1.42194936
44MP0004147_increased_porphyrin_level1.39458822
45MP0003186_abnormal_redox_activity1.37346767
46MP0006072_abnormal_retinal_apoptosis1.37049872
47MP0008058_abnormal_DNA_repair1.36547830
48MP0003786_premature_aging1.34540476
49MP0006036_abnormal_mitochondrial_physio1.34285499
50MP0001845_abnormal_inflammatory_respons1.31749660
51MP0001529_abnormal_vocalization1.30458522
52MP0009764_decreased_sensitivity_to1.28964152
53MP0002722_abnormal_immune_system1.28354601
54MP0002429_abnormal_blood_cell1.27441401
55MP0002638_abnormal_pupillary_reflex1.26175054
56MP0001873_stomach_inflammation1.24187788
57MP0005464_abnormal_platelet_physiology1.20386751
58MP0002102_abnormal_ear_morphology1.18740064
59MP0003122_maternal_imprinting1.18071002
60MP0001853_heart_inflammation1.16189021
61MP0009278_abnormal_bone_marrow1.16131940
62MP0003866_abnormal_defecation1.10701042
63MP0002736_abnormal_nociception_after1.07944799
64MP0002822_catalepsy1.07442275
65MP0008469_abnormal_protein_level1.06064515
66MP0003787_abnormal_imprinting1.05645614
67MP0001986_abnormal_taste_sensitivity1.05172244
68MP0010155_abnormal_intestine_physiology1.05097191
69MP0004742_abnormal_vestibular_system1.04546832
70MP0001984_abnormal_olfaction1.01845610
71MP0000703_abnormal_thymus_morphology1.01501641
72MP0002132_abnormal_respiratory_system0.99163868
73MP0003646_muscle_fatigue0.96492981
74MP0006276_abnormal_autonomic_nervous0.95481778
75MP0001968_abnormal_touch/_nociception0.94823258
76MP0003303_peritoneal_inflammation0.94400984
77MP0006035_abnormal_mitochondrial_morpho0.92393230
78MP0001919_abnormal_reproductive_system0.92215870
79MP0001533_abnormal_skeleton_physiology0.91914940
80MP0004510_myositis0.90659850
81MP0003136_yellow_coat_color0.90370156
82MP0005379_endocrine/exocrine_gland_phen0.90305197
83MP0004885_abnormal_endolymph0.89045759
84MP0000343_altered_response_to0.87662313
85MP0001545_abnormal_hematopoietic_system0.85877104
86MP0005397_hematopoietic_system_phenotyp0.85877104
87MP0001542_abnormal_bone_strength0.85852866
88MP0001663_abnormal_digestive_system0.85579120
89MP0002095_abnormal_skin_pigmentation0.84914938
90MP0008872_abnormal_physiological_respon0.84905161
91MP0003880_abnormal_central_pattern0.84592673
92MP0003121_genomic_imprinting0.82807382
93MP0002837_dystrophic_cardiac_calcinosis0.82798945
94MP0000465_gastrointestinal_hemorrhage0.82671361
95MP0009765_abnormal_xenobiotic_induced0.81455137
96MP0002933_joint_inflammation0.80950514
97MP0009745_abnormal_behavioral_response0.78989296
98MP0001970_abnormal_pain_threshold0.78125974
99MP0001764_abnormal_homeostasis0.75096117
100MP0001485_abnormal_pinna_reflex0.72431732

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.10894351
2Abnormal mitochondria in muscle tissue (HP:0008316)4.75360147
3Mitochondrial inheritance (HP:0001427)4.71874376
4Acute encephalopathy (HP:0006846)4.29126986
5Progressive macrocephaly (HP:0004481)4.14120393
6Hepatocellular necrosis (HP:0001404)4.08186678
7Increased CSF lactate (HP:0002490)4.05783509
8Hepatic necrosis (HP:0002605)3.68493737
9Reticulocytopenia (HP:0001896)3.58634696
10Increased hepatocellular lipid droplets (HP:0006565)3.55814220
11Abnormal number of erythroid precursors (HP:0012131)3.44586090
12Abnormality of cells of the erythroid lineage (HP:0012130)3.43726727
133-Methylglutaconic aciduria (HP:0003535)3.36904184
14Lipid accumulation in hepatocytes (HP:0006561)3.33350621
15Increased intramyocellular lipid droplets (HP:0012240)3.32273104
16Elevated erythrocyte sedimentation rate (HP:0003565)3.23852814
17Renal Fanconi syndrome (HP:0001994)3.21754507
18Cerebral edema (HP:0002181)3.11672913
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98558748
20Increased IgM level (HP:0003496)2.92076600
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.91714671
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.91714671
23Increased muscle lipid content (HP:0009058)2.91255505
24IgG deficiency (HP:0004315)2.89593030
25Stomatitis (HP:0010280)2.78060530
26Optic disc pallor (HP:0000543)2.75545813
27Exertional dyspnea (HP:0002875)2.66671409
28Aplastic anemia (HP:0001915)2.66490489
29Lactic acidosis (HP:0003128)2.66133567
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.59901812
31Exercise intolerance (HP:0003546)2.54931151
32Increased serum lactate (HP:0002151)2.50913258
33Respiratory difficulties (HP:0002880)2.48197167
34IgM deficiency (HP:0002850)2.47748854
35Neutropenia (HP:0001875)2.46441998
36Abnormality of B cell number (HP:0010975)2.44530526
37Obstructive lung disease (HP:0006536)2.44276128
38Chronic obstructive pulmonary disease (HP:0006510)2.44276128
39Panhypogammaglobulinemia (HP:0003139)2.36653930
40Agammaglobulinemia (HP:0004432)2.36278851
41Respiratory failure (HP:0002878)2.32771694
42Abnormality of the prostate (HP:0008775)2.27739227
43Methylmalonic aciduria (HP:0012120)2.27527605
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.27033265
45Pancytopenia (HP:0001876)2.26591950
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.26525766
47Dicarboxylic aciduria (HP:0003215)2.26525766
48Type I transferrin isoform profile (HP:0003642)2.23249214
49Abnormality of T cells (HP:0002843)2.20318531
50Macrocytic anemia (HP:0001972)2.19377074
51B lymphocytopenia (HP:0010976)2.17853918
52Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14798063
53Meningitis (HP:0001287)2.14188287
54Severe combined immunodeficiency (HP:0004430)2.13199601
55Abnormal rod and cone electroretinograms (HP:0008323)2.11927579
56Pallor (HP:0000980)2.10616191
57Polyphagia (HP:0002591)2.09882957
58Congenital stationary night blindness (HP:0007642)2.08299551
59Lethargy (HP:0001254)2.07870300
60Abnormality of midbrain morphology (HP:0002418)2.07384021
61Molar tooth sign on MRI (HP:0002419)2.07384021
62Abnormal protein glycosylation (HP:0012346)2.06667823
63Abnormal glycosylation (HP:0012345)2.06667823
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.06667823
65Abnormal protein N-linked glycosylation (HP:0012347)2.06667823
66Muscle fiber atrophy (HP:0100295)2.06355542
67Emotional lability (HP:0000712)2.02477009
68Petechiae (HP:0000967)2.02467975
69Leukodystrophy (HP:0002415)1.99473743
70Abnormality of T cell number (HP:0011839)1.99080304
71Medial flaring of the eyebrow (HP:0010747)1.97656738
72Pancreatic cysts (HP:0001737)1.97607539
73Lymphopenia (HP:0001888)1.97012116
74Type 2 muscle fiber atrophy (HP:0003554)1.95228636
75Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94382974
76Encephalitis (HP:0002383)1.94062838
77T lymphocytopenia (HP:0005403)1.92890409
78Cerebral palsy (HP:0100021)1.92610523
79Colon cancer (HP:0003003)1.92062472
80Abnormality of renal resorption (HP:0011038)1.90781975
81Pancreatic fibrosis (HP:0100732)1.90659107
82Methylmalonic acidemia (HP:0002912)1.89948737
83Mediastinal lymphadenopathy (HP:0100721)1.88592892
84Granulocytopenia (HP:0001913)1.85302215
85Absent thumb (HP:0009777)1.84716099
86True hermaphroditism (HP:0010459)1.84510566
87Septo-optic dysplasia (HP:0100842)1.82871453
88Severe visual impairment (HP:0001141)1.82865865
89Generalized aminoaciduria (HP:0002909)1.81845627
90Abnormality of eosinophils (HP:0001879)1.80015849
91Constricted visual fields (HP:0001133)1.79656998
92Abnormality of the labia minora (HP:0012880)1.79431366
93Combined immunodeficiency (HP:0005387)1.79070957
94Eosinophilia (HP:0001880)1.78723005
95Progressive microcephaly (HP:0000253)1.78181671
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.77661531
97Recurrent fungal infections (HP:0002841)1.76170525
98Vasculitis (HP:0002633)1.75939679
99Pulmonary fibrosis (HP:0002206)1.75078886
100Abnormality of the heme biosynthetic pathway (HP:0010472)1.72632455

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.36505901
2TXK4.00757923
3BCKDK3.62740286
4TESK23.32607396
5MAP4K13.28324457
6KDR2.73343953
7TAOK32.72338633
8STK162.49224398
9MAP4K22.34995408
10CDK192.29306026
11NME22.23713305
12VRK12.13395359
13TESK11.82941203
14NUAK11.71958216
15FES1.70745184
16MAP3K111.66235607
17TLK11.63989044
18ADRBK21.60044703
19LIMK11.59387607
20KIT1.58161592
21DYRK21.56214834
22ARAF1.53868129
23ZAK1.49235389
24SYK1.37228482
25GRK71.36757294
26IKBKB1.35879065
27BUB11.33063442
28PIM21.32582413
29RIPK41.16701044
30IKBKE1.14661944
31TBK11.03526632
32MAP3K121.01540162
33IRAK40.99493533
34MAP2K70.96948204
35SIK20.96118612
36BTK0.92548018
37LYN0.92317558
38CSNK1G30.91045060
39PRKCQ0.89870469
40ITK0.88691231
41SRPK10.86978139
42BRAF0.86881612
43MATK0.85324737
44BMPR1B0.83875309
45WNK30.83647896
46NME10.82544633
47RPS6KA50.80905177
48GRK60.80794047
49MARK30.79096558
50TRIM280.78046621
51PINK10.77859038
52LRRK20.74192763
53TAF10.73898954
54AURKA0.73107559
55CSNK1G20.72204837
56TNK20.71883269
57CCNB10.71311677
58MOS0.71221555
59MAPK130.71032139
60CSF1R0.70701297
61ABL20.69346342
62TYK20.68951812
63PASK0.68344070
64LCK0.67177296
65CSNK1G10.66817319
66GRK10.65731441
67SIK30.65329990
68TEC0.64873768
69CSK0.64848785
70DAPK10.63619444
71DAPK30.63407476
72JAK30.55787998
73ZAP700.54454276
74PIM10.52940185
75PRKCG0.51327617
76PAK10.49016548
77RPS6KA40.47791835
78GRK50.47280878
79CDC70.46933909
80CSNK1A1L0.46238341
81MST40.45314683
82PKN10.44437802
83CSNK2A10.42726699
84PRKCD0.41105915
85BLK0.40328035
86INSRR0.39990494
87ATR0.39961840
88DYRK1B0.38692265
89MAPK150.38663961
90CDK80.38634297
91CDK140.38491509
92CSNK2A20.38449304
93ILK0.37905960
94DYRK30.37903282
95MAP2K20.37402261
96TAOK20.36914444
97EPHB20.35312821
98ADRBK10.35046180
99CDK11A0.31347239
100HCK0.31289064

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.40756813
2Ribosome_Homo sapiens_hsa030104.18099597
3Proteasome_Homo sapiens_hsa030503.85443675
4Parkinsons disease_Homo sapiens_hsa050123.82983983
5Primary immunodeficiency_Homo sapiens_hsa053402.96373621
6Allograft rejection_Homo sapiens_hsa053302.70184800
7Autoimmune thyroid disease_Homo sapiens_hsa053202.59620852
8Asthma_Homo sapiens_hsa053102.58066009
9Graft-versus-host disease_Homo sapiens_hsa053322.57777334
10Huntingtons disease_Homo sapiens_hsa050162.47096193
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.45899607
12Alzheimers disease_Homo sapiens_hsa050102.41119397
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.30391467
14Type I diabetes mellitus_Homo sapiens_hsa049402.18349497
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15492912
16RNA polymerase_Homo sapiens_hsa030202.14585442
17Protein export_Homo sapiens_hsa030602.05811192
18Antigen processing and presentation_Homo sapiens_hsa046121.92731992
19Rheumatoid arthritis_Homo sapiens_hsa053231.61244667
20Mismatch repair_Homo sapiens_hsa034301.55554579
21Cardiac muscle contraction_Homo sapiens_hsa042601.54088151
22DNA replication_Homo sapiens_hsa030301.50458749
23Homologous recombination_Homo sapiens_hsa034401.50215507
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48377330
25Base excision repair_Homo sapiens_hsa034101.47270032
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44439927
27Hematopoietic cell lineage_Homo sapiens_hsa046401.34033407
28Pyrimidine metabolism_Homo sapiens_hsa002401.29524866
29Viral myocarditis_Homo sapiens_hsa054161.19151328
30Sulfur relay system_Homo sapiens_hsa041221.17069206
31Spliceosome_Homo sapiens_hsa030401.15726227
32Staphylococcus aureus infection_Homo sapiens_hsa051500.98737592
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96860930
34Fanconi anemia pathway_Homo sapiens_hsa034600.95536304
35Nucleotide excision repair_Homo sapiens_hsa034200.93125881
36RNA degradation_Homo sapiens_hsa030180.92506605
37Leishmaniasis_Homo sapiens_hsa051400.92172640
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91141960
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88562734
40NF-kappa B signaling pathway_Homo sapiens_hsa040640.87486006
41Collecting duct acid secretion_Homo sapiens_hsa049660.87272386
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84941604
43Phototransduction_Homo sapiens_hsa047440.83737893
44Basal transcription factors_Homo sapiens_hsa030220.82515267
45Systemic lupus erythematosus_Homo sapiens_hsa053220.80367818
46Fatty acid elongation_Homo sapiens_hsa000620.79169243
47Purine metabolism_Homo sapiens_hsa002300.77843257
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76111595
49Peroxisome_Homo sapiens_hsa041460.73857013
50Epstein-Barr virus infection_Homo sapiens_hsa051690.73494687
51Glutathione metabolism_Homo sapiens_hsa004800.72937970
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72909853
53Herpes simplex infection_Homo sapiens_hsa051680.71166477
54Regulation of autophagy_Homo sapiens_hsa041400.70072015
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68535234
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67519871
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66360031
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.62330857
59Folate biosynthesis_Homo sapiens_hsa007900.61052605
60Arachidonic acid metabolism_Homo sapiens_hsa005900.58807905
61Salmonella infection_Homo sapiens_hsa051320.57588006
62T cell receptor signaling pathway_Homo sapiens_hsa046600.55967156
63Shigellosis_Homo sapiens_hsa051310.53371124
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52740728
65Non-homologous end-joining_Homo sapiens_hsa034500.52510316
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50718018
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50533093
68Measles_Homo sapiens_hsa051620.50294023
69Metabolic pathways_Homo sapiens_hsa011000.49456232
70Phagosome_Homo sapiens_hsa041450.49378700
71Sulfur metabolism_Homo sapiens_hsa009200.48331848
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47752688
73Linoleic acid metabolism_Homo sapiens_hsa005910.46932498
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46001803
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45247931
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43619259
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43322143
78Butanoate metabolism_Homo sapiens_hsa006500.41563960
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40683569
80Tuberculosis_Homo sapiens_hsa051520.39713971
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39063312
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36181632
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35380786
84Osteoclast differentiation_Homo sapiens_hsa043800.32485207
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32437379
86Legionellosis_Homo sapiens_hsa051340.31987846
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31958518
88Tryptophan metabolism_Homo sapiens_hsa003800.27027657
89Pertussis_Homo sapiens_hsa051330.26677253
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26388690
91Chemokine signaling pathway_Homo sapiens_hsa040620.24711091
92Propanoate metabolism_Homo sapiens_hsa006400.24281653
93Influenza A_Homo sapiens_hsa051640.21604893
94Malaria_Homo sapiens_hsa051440.21392872
95HTLV-I infection_Homo sapiens_hsa051660.20968856
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20822539
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.20619461
98African trypanosomiasis_Homo sapiens_hsa051430.19478862
99Alcoholism_Homo sapiens_hsa050340.18561822
100RNA transport_Homo sapiens_hsa030130.18445898

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