ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.38107240
2	DNA deamination (GO:0045006)	5.20530583
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.20406755
4	ATP synthesis coupled proton transport (GO:0015986)	5.20406755
5	ribosomal small subunit assembly (GO:0000028)	4.84537488
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.70140050
7	viral transcription (GO:0019083)	4.59081450
8	cytidine metabolic process (GO:0046087)	4.38134874
9	cytidine catabolic process (GO:0006216)	4.38134874
10	cytidine deamination (GO:0009972)	4.38134874
11	translational termination (GO:0006415)	4.30890489
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.30770926
13	protein neddylation (GO:0045116)	4.29680660
14	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.20594654
15	chaperone-mediated protein transport (GO:0072321)	4.12328079
16	respiratory electron transport chain (GO:0022904)	4.11805315
17	protein complex biogenesis (GO:0070271)	4.06002507
18	electron transport chain (GO:0022900)	4.05762986
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.02584522
20	protein targeting to ER (GO:0045047)	3.97532431
21	cotranslational protein targeting to membrane (GO:0006613)	3.96313207
22	sequestering of actin monomers (GO:0042989)	3.90953980
23	translational elongation (GO:0006414)	3.85152309
24	protein localization to endoplasmic reticulum (GO:0070972)	3.79787244
25	ribosomal small subunit biogenesis (GO:0042274)	3.79591614
26	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.76677186
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.74599526
28	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.72235878
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.68471647
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.68471647
31	NADH dehydrogenase complex assembly (GO:0010257)	3.68471647
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.67365174
33	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.67365174
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60958339
35	viral life cycle (GO:0019058)	3.60672760
36	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.39582768
37	negative regulation of telomere maintenance (GO:0032205)	3.35854741
38	cellular protein complex disassembly (GO:0043624)	3.26370458
39	response to interferon-beta (GO:0035456)	3.19637067
40	purine deoxyribonucleotide catabolic process (GO:0009155)	3.18041291
41	deoxyribonucleotide catabolic process (GO:0009264)	3.17382875
42	maturation of SSU-rRNA (GO:0030490)	3.15174337
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.10212256
44	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.09087890
45	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	3.08281355
46	immunoglobulin mediated immune response (GO:0016064)	3.05366773
47	platelet dense granule organization (GO:0060155)	3.04663986
48	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.00629314
49	proteasome assembly (GO:0043248)	3.00542099
50	cellular response to interferon-beta (GO:0035458)	2.98870206
51	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.97794824
52	cytochrome complex assembly (GO:0017004)	2.97694790
53	translational initiation (GO:0006413)	2.97053195
54	deoxyribose phosphate catabolic process (GO:0046386)	2.96324222
55	ATP biosynthetic process (GO:0006754)	2.93306415
56	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.92852760
57	regulation of cellular amino acid metabolic process (GO:0006521)	2.91213542
58	iron-sulfur cluster assembly (GO:0016226)	2.90747343
59	metallo-sulfur cluster assembly (GO:0031163)	2.90747343
60	hydrogen ion transmembrane transport (GO:1902600)	2.88163820
61	translation (GO:0006412)	2.86214327
62	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.84881690
63	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.84881690
64	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.84227495
65	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.84227495
66	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.84227495
67	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.84114462
68	negative regulation of B cell apoptotic process (GO:0002903)	2.80141441
69	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.80063728
70	pyrimidine nucleotide catabolic process (GO:0006244)	2.79938171
71	T cell migration (GO:0072678)	2.79651129
72	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.79420789
73	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78686024
74	protein complex disassembly (GO:0043241)	2.77563102
75	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.76895878
76	negative regulation of ligase activity (GO:0051352)	2.76243077
77	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.76243077
78	inner mitochondrial membrane organization (GO:0007007)	2.74701803
79	viral protein processing (GO:0019082)	2.73021575
80	termination of RNA polymerase III transcription (GO:0006386)	2.72556376
81	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.72556376
82	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.72304251
83	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.68775338
84	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.68485510
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68282085
86	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.67960888
87	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.66882168
88	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.66882168
89	macromolecular complex disassembly (GO:0032984)	2.65490050
90	2-deoxyribonucleotide metabolic process (GO:0009394)	2.64609963
91	establishment of protein localization to mitochondrion (GO:0072655)	2.64310534
92	NIK/NF-kappaB signaling (GO:0038061)	2.63328407
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.63036029
94	proton transport (GO:0015992)	2.63006838
95	respiratory chain complex IV assembly (GO:0008535)	2.62636027
96	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62285932
97	positive regulation of defense response to virus by host (GO:0002230)	2.62017545
98	protein targeting to mitochondrion (GO:0006626)	2.61791785
99	purine deoxyribonucleotide metabolic process (GO:0009151)	2.61225596
100	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.59952487

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.93356458
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.76608223
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.55008774
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.42639212
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.40055223
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38595399
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.30744688
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.29888062
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.10028817
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.92595990
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.83858345
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71737947
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.69393478
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42987168
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.39138548
16	* VDR_23849224_ChIP-Seq_CD4+_Human	2.34735536
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.29870934
18	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.18818875
19	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.16369240
20	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.16072660
21	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.12458721
22	FOXP3_21729870_ChIP-Seq_TREG_Human	2.11456051
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.06141772
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.04339060
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.01391800
26	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.01359836
27	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.93680757
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.88921640
29	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.88182251
30	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.74870138
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.71020390
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.69070519
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.68960111
34	CIITA_25753668_ChIP-Seq_RAJI_Human	1.67172435
35	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.65528989
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.60321551
37	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.58654979
38	EZH2_22144423_ChIP-Seq_EOC_Human	1.57475829
39	BCL6_27268052_Chip-Seq_Bcells_Human	1.54562399
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.54435144
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.54017600
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.52492539
43	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.49283194
44	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.49148626
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.45687509
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.41048153
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39617777
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.39338572
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38001594
50	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.37782057
51	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.33504273
52	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.33246939
53	* SPI1_23547873_ChIP-Seq_NB4_Human	1.31470456
54	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.31002153
55	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.30389122
56	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.29795217
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.29745262
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28943000
59	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.28118885
60	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.25322999
61	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.25077600
62	MAF_26560356_Chip-Seq_TH2_Human	1.21926226
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.20301052
64	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17427368
65	* MYB_26560356_Chip-Seq_TH2_Human	1.16961465
66	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.15092834
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.14734979
68	UTX_26944678_Chip-Seq_JUKART_Human	1.14456251
69	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.14096979
70	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.11852417
71	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09718396
72	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08814205
73	ZNF274_21170338_ChIP-Seq_K562_Hela	1.07224445
74	BCOR_27268052_Chip-Seq_Bcells_Human	1.06539040
75	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05830397
76	VDR_21846776_ChIP-Seq_THP-1_Human	1.05802423
77	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04963861
78	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.04607213
79	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.03234435
80	P300_27268052_Chip-Seq_Bcells_Human	1.01295031
81	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99981579
82	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.99562693
83	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99433571
84	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99121003
85	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.98892347
86	E2F1_20622854_ChIP-Seq_HELA_Human	0.97761553
87	CTCF_20526341_ChIP-Seq_ESCs_Human	0.97000670
88	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.96697433
89	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.95374397
90	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.93435974
91	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.93259300
92	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.92600328
93	* MAF_26560356_Chip-Seq_TH1_Human	0.92318845
94	GATA3_26560356_Chip-Seq_TH2_Human	0.92263275
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92168778
96	STAT1_20625510_ChIP-Seq_HELA_Human	0.92084045
97	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.91910746
98	TP53_22573176_ChIP-Seq_HFKS_Human	0.90975754
99	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.90959536
100	PHF8_20622854_ChIP-Seq_HELA_Human	0.90954851

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.93451114
2	MP0001835_abnormal_antigen_presentation	2.68687881
3	MP0009379_abnormal_foot_pigmentation	2.65325050
4	MP0002148_abnormal_hypersensitivity_rea	2.57517977
5	MP0009785_altered_susceptibility_to	2.53809868
6	MP0002653_abnormal_ependyma_morphology	2.51317049
7	MP0001800_abnormal_humoral_immune	2.32128646
8	MP0005387_immune_system_phenotype	2.27607382
9	MP0001790_abnormal_immune_system	2.27607382
10	MP0005084_abnormal_gallbladder_morpholo	2.26073485
11	MP0005000_abnormal_immune_tolerance	2.22770683
12	MP0002723_abnormal_immune_serum	2.11448257
13	MP0005025_abnormal_response_to	2.09953311
14	MP0006292_abnormal_olfactory_placode	2.07496754
15	MP0000685_abnormal_immune_system	1.99888204
16	MP0002420_abnormal_adaptive_immunity	1.97550774
17	MP0001819_abnormal_immune_cell	1.94256948
18	MP0009333_abnormal_splenocyte_physiolog	1.93167199
19	MP0002138_abnormal_hepatobiliary_system	1.88966787
20	MP0006082_CNS_inflammation	1.88891916
21	MP0003436_decreased_susceptibility_to	1.88853588
22	MP0002452_abnormal_antigen_presenting	1.87813706
23	MP0008789_abnormal_olfactory_epithelium	1.87222263
24	MP0002277_abnormal_respiratory_mucosa	1.84970690
25	MP0003806_abnormal_nucleotide_metabolis	1.80831326
26	MP0003763_abnormal_thymus_physiology	1.80018671
27	MP0000372_irregular_coat_pigmentation	1.73379101
28	MP0004142_abnormal_muscle_tone	1.72805957
29	MP0002163_abnormal_gland_morphology	1.62097267
30	MP0003724_increased_susceptibility_to	1.59875254
31	MP0003011_delayed_dark_adaptation	1.59450035
32	MP0005075_abnormal_melanosome_morpholog	1.57207015
33	MP0002398_abnormal_bone_marrow	1.57134896
34	MP0000716_abnormal_immune_system	1.54995272
35	MP0002419_abnormal_innate_immunity	1.54624807
36	MP0005394_taste/olfaction_phenotype	1.54437071
37	MP0005499_abnormal_olfactory_system	1.54437071
38	MP0008995_early_reproductive_senescence	1.53021552
39	MP0001905_abnormal_dopamine_level	1.52101729
40	MP0005645_abnormal_hypothalamus_physiol	1.49503862
41	MP0008877_abnormal_DNA_methylation	1.49386811
42	MP0002405_respiratory_system_inflammati	1.45980989
43	MP0000689_abnormal_spleen_morphology	1.42194936
44	MP0004147_increased_porphyrin_level	1.39458822
45	MP0003186_abnormal_redox_activity	1.37346767
46	MP0006072_abnormal_retinal_apoptosis	1.37049872
47	MP0008058_abnormal_DNA_repair	1.36547830
48	MP0003786_premature_aging	1.34540476
49	MP0006036_abnormal_mitochondrial_physio	1.34285499
50	MP0001845_abnormal_inflammatory_respons	1.31749660
51	MP0001529_abnormal_vocalization	1.30458522
52	MP0009764_decreased_sensitivity_to	1.28964152
53	MP0002722_abnormal_immune_system	1.28354601
54	MP0002429_abnormal_blood_cell	1.27441401
55	MP0002638_abnormal_pupillary_reflex	1.26175054
56	MP0001873_stomach_inflammation	1.24187788
57	MP0005464_abnormal_platelet_physiology	1.20386751
58	MP0002102_abnormal_ear_morphology	1.18740064
59	MP0003122_maternal_imprinting	1.18071002
60	MP0001853_heart_inflammation	1.16189021
61	MP0009278_abnormal_bone_marrow	1.16131940
62	MP0003866_abnormal_defecation	1.10701042
63	MP0002736_abnormal_nociception_after	1.07944799
64	MP0002822_catalepsy	1.07442275
65	MP0008469_abnormal_protein_level	1.06064515
66	MP0003787_abnormal_imprinting	1.05645614
67	MP0001986_abnormal_taste_sensitivity	1.05172244
68	MP0010155_abnormal_intestine_physiology	1.05097191
69	MP0004742_abnormal_vestibular_system	1.04546832
70	MP0001984_abnormal_olfaction	1.01845610
71	MP0000703_abnormal_thymus_morphology	1.01501641
72	MP0002132_abnormal_respiratory_system	0.99163868
73	MP0003646_muscle_fatigue	0.96492981
74	MP0006276_abnormal_autonomic_nervous	0.95481778
75	MP0001968_abnormal_touch/_nociception	0.94823258
76	MP0003303_peritoneal_inflammation	0.94400984
77	MP0006035_abnormal_mitochondrial_morpho	0.92393230
78	MP0001919_abnormal_reproductive_system	0.92215870
79	MP0001533_abnormal_skeleton_physiology	0.91914940
80	MP0004510_myositis	0.90659850
81	MP0003136_yellow_coat_color	0.90370156
82	MP0005379_endocrine/exocrine_gland_phen	0.90305197
83	MP0004885_abnormal_endolymph	0.89045759
84	MP0000343_altered_response_to	0.87662313
85	MP0001545_abnormal_hematopoietic_system	0.85877104
86	MP0005397_hematopoietic_system_phenotyp	0.85877104
87	MP0001542_abnormal_bone_strength	0.85852866
88	MP0001663_abnormal_digestive_system	0.85579120
89	MP0002095_abnormal_skin_pigmentation	0.84914938
90	MP0008872_abnormal_physiological_respon	0.84905161
91	MP0003880_abnormal_central_pattern	0.84592673
92	MP0003121_genomic_imprinting	0.82807382
93	MP0002837_dystrophic_cardiac_calcinosis	0.82798945
94	MP0000465_gastrointestinal_hemorrhage	0.82671361
95	MP0009765_abnormal_xenobiotic_induced	0.81455137
96	MP0002933_joint_inflammation	0.80950514
97	MP0009745_abnormal_behavioral_response	0.78989296
98	MP0001970_abnormal_pain_threshold	0.78125974
99	MP0001764_abnormal_homeostasis	0.75096117
100	MP0001485_abnormal_pinna_reflex	0.72431732

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.10894351
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.75360147
3	Mitochondrial inheritance (HP:0001427)	4.71874376
4	Acute encephalopathy (HP:0006846)	4.29126986
5	Progressive macrocephaly (HP:0004481)	4.14120393
6	Hepatocellular necrosis (HP:0001404)	4.08186678
7	Increased CSF lactate (HP:0002490)	4.05783509
8	Hepatic necrosis (HP:0002605)	3.68493737
9	Reticulocytopenia (HP:0001896)	3.58634696
10	Increased hepatocellular lipid droplets (HP:0006565)	3.55814220
11	Abnormal number of erythroid precursors (HP:0012131)	3.44586090
12	Abnormality of cells of the erythroid lineage (HP:0012130)	3.43726727
13	3-Methylglutaconic aciduria (HP:0003535)	3.36904184
14	Lipid accumulation in hepatocytes (HP:0006561)	3.33350621
15	Increased intramyocellular lipid droplets (HP:0012240)	3.32273104
16	Elevated erythrocyte sedimentation rate (HP:0003565)	3.23852814
17	Renal Fanconi syndrome (HP:0001994)	3.21754507
18	Cerebral edema (HP:0002181)	3.11672913
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.98558748
20	Increased IgM level (HP:0003496)	2.92076600
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.91714671
22	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.91714671
23	Increased muscle lipid content (HP:0009058)	2.91255505
24	IgG deficiency (HP:0004315)	2.89593030
25	Stomatitis (HP:0010280)	2.78060530
26	Optic disc pallor (HP:0000543)	2.75545813
27	Exertional dyspnea (HP:0002875)	2.66671409
28	Aplastic anemia (HP:0001915)	2.66490489
29	Lactic acidosis (HP:0003128)	2.66133567
30	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.59901812
31	Exercise intolerance (HP:0003546)	2.54931151
32	Increased serum lactate (HP:0002151)	2.50913258
33	Respiratory difficulties (HP:0002880)	2.48197167
34	IgM deficiency (HP:0002850)	2.47748854
35	Neutropenia (HP:0001875)	2.46441998
36	Abnormality of B cell number (HP:0010975)	2.44530526
37	Obstructive lung disease (HP:0006536)	2.44276128
38	Chronic obstructive pulmonary disease (HP:0006510)	2.44276128
39	Panhypogammaglobulinemia (HP:0003139)	2.36653930
40	Agammaglobulinemia (HP:0004432)	2.36278851
41	Respiratory failure (HP:0002878)	2.32771694
42	Abnormality of the prostate (HP:0008775)	2.27739227
43	Methylmalonic aciduria (HP:0012120)	2.27527605
44	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.27033265
45	Pancytopenia (HP:0001876)	2.26591950
46	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.26525766
47	Dicarboxylic aciduria (HP:0003215)	2.26525766
48	Type I transferrin isoform profile (HP:0003642)	2.23249214
49	Abnormality of T cells (HP:0002843)	2.20318531
50	Macrocytic anemia (HP:0001972)	2.19377074
51	B lymphocytopenia (HP:0010976)	2.17853918
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.14798063
53	Meningitis (HP:0001287)	2.14188287
54	Severe combined immunodeficiency (HP:0004430)	2.13199601
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.11927579
56	Pallor (HP:0000980)	2.10616191
57	Polyphagia (HP:0002591)	2.09882957
58	Congenital stationary night blindness (HP:0007642)	2.08299551
59	Lethargy (HP:0001254)	2.07870300
60	Abnormality of midbrain morphology (HP:0002418)	2.07384021
61	Molar tooth sign on MRI (HP:0002419)	2.07384021
62	Abnormal protein glycosylation (HP:0012346)	2.06667823
63	Abnormal glycosylation (HP:0012345)	2.06667823
64	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.06667823
65	Abnormal protein N-linked glycosylation (HP:0012347)	2.06667823
66	Muscle fiber atrophy (HP:0100295)	2.06355542
67	Emotional lability (HP:0000712)	2.02477009
68	Petechiae (HP:0000967)	2.02467975
69	Leukodystrophy (HP:0002415)	1.99473743
70	Abnormality of T cell number (HP:0011839)	1.99080304
71	Medial flaring of the eyebrow (HP:0010747)	1.97656738
72	Pancreatic cysts (HP:0001737)	1.97607539
73	Lymphopenia (HP:0001888)	1.97012116
74	Type 2 muscle fiber atrophy (HP:0003554)	1.95228636
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.94382974
76	Encephalitis (HP:0002383)	1.94062838
77	T lymphocytopenia (HP:0005403)	1.92890409
78	Cerebral palsy (HP:0100021)	1.92610523
79	Colon cancer (HP:0003003)	1.92062472
80	Abnormality of renal resorption (HP:0011038)	1.90781975
81	Pancreatic fibrosis (HP:0100732)	1.90659107
82	Methylmalonic acidemia (HP:0002912)	1.89948737
83	Mediastinal lymphadenopathy (HP:0100721)	1.88592892
84	Granulocytopenia (HP:0001913)	1.85302215
85	Absent thumb (HP:0009777)	1.84716099
86	True hermaphroditism (HP:0010459)	1.84510566
87	Septo-optic dysplasia (HP:0100842)	1.82871453
88	Severe visual impairment (HP:0001141)	1.82865865
89	Generalized aminoaciduria (HP:0002909)	1.81845627
90	Abnormality of eosinophils (HP:0001879)	1.80015849
91	Constricted visual fields (HP:0001133)	1.79656998
92	Abnormality of the labia minora (HP:0012880)	1.79431366
93	Combined immunodeficiency (HP:0005387)	1.79070957
94	Eosinophilia (HP:0001880)	1.78723005
95	Progressive microcephaly (HP:0000253)	1.78181671
96	Abnormality of cells of the lymphoid lineage (HP:0012140)	1.77661531
97	Recurrent fungal infections (HP:0002841)	1.76170525
98	Vasculitis (HP:0002633)	1.75939679
99	Pulmonary fibrosis (HP:0002206)	1.75078886
100	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.72632455

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.36505901
2	TXK	4.00757923
3	BCKDK	3.62740286
4	TESK2	3.32607396
5	MAP4K1	3.28324457
6	KDR	2.73343953
7	TAOK3	2.72338633
8	STK16	2.49224398
9	MAP4K2	2.34995408
10	CDK19	2.29306026
11	NME2	2.23713305
12	VRK1	2.13395359
13	TESK1	1.82941203
14	NUAK1	1.71958216
15	FES	1.70745184
16	MAP3K11	1.66235607
17	TLK1	1.63989044
18	ADRBK2	1.60044703
19	LIMK1	1.59387607
20	KIT	1.58161592
21	DYRK2	1.56214834
22	ARAF	1.53868129
23	ZAK	1.49235389
24	SYK	1.37228482
25	GRK7	1.36757294
26	IKBKB	1.35879065
27	BUB1	1.33063442
28	PIM2	1.32582413
29	RIPK4	1.16701044
30	IKBKE	1.14661944
31	TBK1	1.03526632
32	MAP3K12	1.01540162
33	IRAK4	0.99493533
34	MAP2K7	0.96948204
35	SIK2	0.96118612
36	BTK	0.92548018
37	LYN	0.92317558
38	CSNK1G3	0.91045060
39	PRKCQ	0.89870469
40	ITK	0.88691231
41	SRPK1	0.86978139
42	BRAF	0.86881612
43	MATK	0.85324737
44	BMPR1B	0.83875309
45	WNK3	0.83647896
46	NME1	0.82544633
47	RPS6KA5	0.80905177
48	GRK6	0.80794047
49	MARK3	0.79096558
50	TRIM28	0.78046621
51	PINK1	0.77859038
52	LRRK2	0.74192763
53	TAF1	0.73898954
54	AURKA	0.73107559
55	CSNK1G2	0.72204837
56	TNK2	0.71883269
57	CCNB1	0.71311677
58	MOS	0.71221555
59	MAPK13	0.71032139
60	CSF1R	0.70701297
61	ABL2	0.69346342
62	TYK2	0.68951812
63	PASK	0.68344070
64	LCK	0.67177296
65	CSNK1G1	0.66817319
66	GRK1	0.65731441
67	SIK3	0.65329990
68	TEC	0.64873768
69	CSK	0.64848785
70	DAPK1	0.63619444
71	DAPK3	0.63407476
72	JAK3	0.55787998
73	ZAP70	0.54454276
74	PIM1	0.52940185
75	PRKCG	0.51327617
76	PAK1	0.49016548
77	RPS6KA4	0.47791835
78	GRK5	0.47280878
79	CDC7	0.46933909
80	CSNK1A1L	0.46238341
81	MST4	0.45314683
82	PKN1	0.44437802
83	CSNK2A1	0.42726699
84	PRKCD	0.41105915
85	BLK	0.40328035
86	INSRR	0.39990494
87	ATR	0.39961840
88	DYRK1B	0.38692265
89	MAPK15	0.38663961
90	CDK8	0.38634297
91	CDK14	0.38491509
92	CSNK2A2	0.38449304
93	ILK	0.37905960
94	DYRK3	0.37903282
95	MAP2K2	0.37402261
96	TAOK2	0.36914444
97	EPHB2	0.35312821
98	ADRBK1	0.35046180
99	CDK11A	0.31347239
100	HCK	0.31289064

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	4.40756813
2	Ribosome_Homo sapiens_hsa03010	4.18099597
3	Proteasome_Homo sapiens_hsa03050	3.85443675
4	Parkinsons disease_Homo sapiens_hsa05012	3.82983983
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.96373621
6	Allograft rejection_Homo sapiens_hsa05330	2.70184800
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.59620852
8	Asthma_Homo sapiens_hsa05310	2.58066009
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.57777334
10	Huntingtons disease_Homo sapiens_hsa05016	2.47096193
11	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.45899607
12	Alzheimers disease_Homo sapiens_hsa05010	2.41119397
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.30391467
14	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18349497
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.15492912
16	RNA polymerase_Homo sapiens_hsa03020	2.14585442
17	Protein export_Homo sapiens_hsa03060	2.05811192
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.92731992
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.61244667
20	Mismatch repair_Homo sapiens_hsa03430	1.55554579
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.54088151
22	DNA replication_Homo sapiens_hsa03030	1.50458749
23	Homologous recombination_Homo sapiens_hsa03440	1.50215507
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.48377330
25	Base excision repair_Homo sapiens_hsa03410	1.47270032
26	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.44439927
27	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.34033407
28	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29524866
29	Viral myocarditis_Homo sapiens_hsa05416	1.19151328
30	Sulfur relay system_Homo sapiens_hsa04122	1.17069206
31	Spliceosome_Homo sapiens_hsa03040	1.15726227
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.98737592
33	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.96860930
34	Fanconi anemia pathway_Homo sapiens_hsa03460	0.95536304
35	Nucleotide excision repair_Homo sapiens_hsa03420	0.93125881
36	RNA degradation_Homo sapiens_hsa03018	0.92506605
37	Leishmaniasis_Homo sapiens_hsa05140	0.92172640
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91141960
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.88562734
40	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.87486006
41	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87272386
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84941604
43	Phototransduction_Homo sapiens_hsa04744	0.83737893
44	Basal transcription factors_Homo sapiens_hsa03022	0.82515267
45	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80367818
46	Fatty acid elongation_Homo sapiens_hsa00062	0.79169243
47	Purine metabolism_Homo sapiens_hsa00230	0.77843257
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76111595
49	Peroxisome_Homo sapiens_hsa04146	0.73857013
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.73494687
51	Glutathione metabolism_Homo sapiens_hsa00480	0.72937970
52	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.72909853
53	Herpes simplex infection_Homo sapiens_hsa05168	0.71166477
54	Regulation of autophagy_Homo sapiens_hsa04140	0.70072015
55	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.68535234
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.67519871
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.66360031
58	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.62330857
59	Folate biosynthesis_Homo sapiens_hsa00790	0.61052605
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58807905
61	Salmonella infection_Homo sapiens_hsa05132	0.57588006
62	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55967156
63	Shigellosis_Homo sapiens_hsa05131	0.53371124
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52740728
65	Non-homologous end-joining_Homo sapiens_hsa03450	0.52510316
66	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.50718018
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50533093
68	Measles_Homo sapiens_hsa05162	0.50294023
69	Metabolic pathways_Homo sapiens_hsa01100	0.49456232
70	Phagosome_Homo sapiens_hsa04145	0.49378700
71	Sulfur metabolism_Homo sapiens_hsa00920	0.48331848
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47752688
73	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46932498
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.46001803
75	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.45247931
76	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.43619259
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.43322143
78	Butanoate metabolism_Homo sapiens_hsa00650	0.41563960
79	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40683569
80	Tuberculosis_Homo sapiens_hsa05152	0.39713971
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39063312
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.36181632
83	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35380786
84	Osteoclast differentiation_Homo sapiens_hsa04380	0.32485207
85	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.32437379
86	Legionellosis_Homo sapiens_hsa05134	0.31987846
87	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.31958518
88	Tryptophan metabolism_Homo sapiens_hsa00380	0.27027657
89	Pertussis_Homo sapiens_hsa05133	0.26677253
90	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.26388690
91	Chemokine signaling pathway_Homo sapiens_hsa04062	0.24711091
92	Propanoate metabolism_Homo sapiens_hsa00640	0.24281653
93	Influenza A_Homo sapiens_hsa05164	0.21604893
94	Malaria_Homo sapiens_hsa05144	0.21392872
95	HTLV-I infection_Homo sapiens_hsa05166	0.20968856
96	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.20822539
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.20619461
98	African trypanosomiasis_Homo sapiens_hsa05143	0.19478862
99	Alcoholism_Homo sapiens_hsa05034	0.18561822
100	RNA transport_Homo sapiens_hsa03013	0.18445898

C17ORF49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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