ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.86646404
2	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.87157843
3	glutamate secretion (GO:0014047)	4.77088363
4	synaptic vesicle maturation (GO:0016188)	4.65314473
5	synaptic vesicle exocytosis (GO:0016079)	3.93996107
6	regulation of synaptic vesicle exocytosis (GO:2000300)	3.48669765
7	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.47429735
8	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.45422999
9	protein localization to synapse (GO:0035418)	3.34577066
10	postsynaptic membrane organization (GO:0001941)	3.33359145
11	positive regulation of synapse maturation (GO:0090129)	3.32798485
12	sodium ion export (GO:0071436)	3.32615098
13	locomotory exploration behavior (GO:0035641)	3.25840847
14	cellular potassium ion homeostasis (GO:0030007)	3.24900572
15	regulation of neuronal synaptic plasticity (GO:0048168)	3.17894135
16	amino acid import (GO:0043090)	3.16661683
17	regulation of synaptic vesicle transport (GO:1902803)	3.13718130
18	neurotransmitter secretion (GO:0007269)	3.11115778
19	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.03523418
20	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.00778141
21	synaptic vesicle endocytosis (GO:0048488)	2.84014571
22	exploration behavior (GO:0035640)	2.83639573
23	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.78502619
24	cerebellar granule cell differentiation (GO:0021707)	2.78100152
25	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.73229441
26	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.69765418
27	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.69674779
28	cellular protein complex localization (GO:0034629)	2.68081964
29	positive regulation of dendritic spine development (GO:0060999)	2.64885392
30	neurotransmitter-gated ion channel clustering (GO:0072578)	2.61059785
31	L-amino acid import (GO:0043092)	2.59508457
32	cerebellar Purkinje cell layer development (GO:0021680)	2.59006834
33	synaptic transmission, glutamatergic (GO:0035249)	2.56868729
34	layer formation in cerebral cortex (GO:0021819)	2.56839977
35	vocalization behavior (GO:0071625)	2.50674755
36	protein complex localization (GO:0031503)	2.49685473
37	regulation of synaptic plasticity (GO:0048167)	2.48853870
38	neuronal action potential propagation (GO:0019227)	2.48324105
39	embryonic skeletal joint morphogenesis (GO:0060272)	2.46516626
40	positive regulation of neurotransmitter transport (GO:0051590)	2.46269976
41	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.46244229
42	regulation of dendritic spine morphogenesis (GO:0061001)	2.44634279
43	cell migration in hindbrain (GO:0021535)	2.42989212
44	neuron-neuron synaptic transmission (GO:0007270)	2.42738823
45	regulation of synapse maturation (GO:0090128)	2.40650236
46	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.40118999
47	neurotransmitter transport (GO:0006836)	2.40050080
48	mitotic sister chromatid cohesion (GO:0007064)	2.39549485
49	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.38418523
50	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.37286393
51	regulation of glutamate receptor signaling pathway (GO:1900449)	2.36898974
52	neuromuscular process controlling balance (GO:0050885)	2.35944203
53	regulation of neurotransmitter secretion (GO:0046928)	2.35917492
54	nuclear pore complex assembly (GO:0051292)	2.35604600
55	regulation of voltage-gated calcium channel activity (GO:1901385)	2.34530183
56	cell communication by electrical coupling (GO:0010644)	2.33497251
57	chemosensory behavior (GO:0007635)	2.33217324
58	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.32911453
59	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.32141320
60	behavioral response to cocaine (GO:0048148)	2.31502458
61	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.30668910
62	DNA unwinding involved in DNA replication (GO:0006268)	2.29976186
63	negative regulation of dendrite morphogenesis (GO:0050774)	2.29810143
64	mitotic chromosome condensation (GO:0007076)	2.26900393
65	positive regulation of neurotransmitter secretion (GO:0001956)	2.26706544
66	neuron cell-cell adhesion (GO:0007158)	2.26471188
67	positive regulation of membrane potential (GO:0045838)	2.25722356
68	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.25409589
69	nuclear pore organization (GO:0006999)	2.24300440
70	glutamate receptor signaling pathway (GO:0007215)	2.23879277
71	regulation of synapse structural plasticity (GO:0051823)	2.23697035
72	regulation of mitotic spindle organization (GO:0060236)	2.23450476
73	regulation of dendritic spine development (GO:0060998)	2.22760175
74	regulation of neurotransmitter transport (GO:0051588)	2.20341566
75	regulation of translational fidelity (GO:0006450)	2.19434930
76	regulation of vesicle fusion (GO:0031338)	2.18995724
77	proximal/distal pattern formation (GO:0009954)	2.17912012
78	mating behavior (GO:0007617)	2.15530509
79	righting reflex (GO:0060013)	2.14789793
80	regulation of postsynaptic membrane potential (GO:0060078)	2.14334181
81	neuromuscular process (GO:0050905)	2.12247475
82	neuron recognition (GO:0008038)	2.09702545
83	neuronal ion channel clustering (GO:0045161)	2.09385214
84	mitotic sister chromatid segregation (GO:0000070)	2.08214212
85	axon cargo transport (GO:0008088)	2.07677829
86	paraxial mesoderm development (GO:0048339)	2.06779049
87	positive regulation of synapse assembly (GO:0051965)	2.06341823
88	dendritic spine organization (GO:0097061)	2.05744069
89	regulation of neurotransmitter levels (GO:0001505)	2.04142110
90	DNA replication checkpoint (GO:0000076)	2.02586383
91	peripheral nervous system axon ensheathment (GO:0032292)	2.02267593
92	myelination in peripheral nervous system (GO:0022011)	2.02267593
93	regulation of NFAT protein import into nucleus (GO:0051532)	2.01868731
94	presynaptic membrane assembly (GO:0097105)	2.01052234
95	axonal fasciculation (GO:0007413)	2.00794513
96	gamma-aminobutyric acid transport (GO:0015812)	2.00574187
97	regulation of synapse assembly (GO:0051963)	2.00179538
98	transmission of nerve impulse (GO:0019226)	1.99210637
99	membrane depolarization during action potential (GO:0086010)	1.99060133
100	regulation of synaptic transmission (GO:0050804)	1.98407303

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.34022968
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.91491549
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.75928144
4	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.82341267
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.79532416
6	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.74308123
7	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.58286639
8	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.58286639
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.54954166
10	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.40881326
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.37391863
12	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.33366631
13	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.28138255
14	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.15907399
15	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.08513333
16	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.03964160
17	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.03404838
18	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.98252196
19	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.96917648
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.91749791
21	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.86748353
22	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.86380220
23	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.85341180
24	REST_21632747_ChIP-Seq_MESCs_Mouse	1.85306368
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79440899
26	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.76897314
27	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.74072882
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.73278867
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.72830299
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.70849162
31	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.69288117
32	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.67261793
33	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.64841735
34	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.64667343
35	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.55955945
36	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.54606252
37	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.49560538
38	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.49541021
39	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.43132594
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.40708099
41	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.40640648
42	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.40212261
43	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.35098608
44	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.31686374
45	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.31488404
46	XRN2_22483619_ChIP-Seq_HELA_Human	1.28853315
47	KDM2B_26808549_Chip-Seq_K562_Human	1.26569365
48	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.25944051
49	AR_21909140_ChIP-Seq_LNCAP_Human	1.25637121
50	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.24993401
51	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.23987159
52	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.22549281
53	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.16714489
54	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.16031895
55	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.11339292
56	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.10414217
57	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.10207448
58	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.09834028
59	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.08590188
60	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.08386188
61	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.07966729
62	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.07772143
63	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.07069872
64	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	1.06996590
65	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.06858267
66	DROSHA_22980978_ChIP-Seq_HELA_Human	1.06558638
67	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.06340655
68	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.04690797
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.02177515
70	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.00389293
71	SOX9_26525672_Chip-Seq_HEART_Mouse	0.99541291
72	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.99343789
73	GBX2_23144817_ChIP-Seq_PC3_Human	0.98144419
74	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97528053
75	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.97390715
76	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.97054671
77	TTF2_22483619_ChIP-Seq_HELA_Human	0.96690836
78	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.94000452
79	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.89153065
80	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.88419946
81	AR_19668381_ChIP-Seq_PC3_Human	0.88132593
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.86266834
83	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.86178985
84	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.85932525
85	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.85838115
86	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.85154228
87	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.84314185
88	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.83994830
89	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.82055118
90	POU3F1_26484290_ChIP-Seq_ESCss_Mouse	0.81035953
91	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.78710945
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.77960594
93	CTCF_27219007_Chip-Seq_Bcells_Human	0.77291851
94	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.77146935
95	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.76609118
96	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.76421592
97	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.76033552
98	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.75996151
99	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.75281852
100	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.75062698

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.26356356
2	MP0005623_abnormal_meninges_morphology	3.26311438
3	MP0003880_abnormal_central_pattern	2.66534227
4	MP0004270_analgesia	2.66000088
5	MP0003635_abnormal_synaptic_transmissio	2.46168703
6	MP0002064_seizures	2.18891485
7	MP0005423_abnormal_somatic_nervous	2.12100182
8	MP0009046_muscle_twitch	2.07930952
9	MP0002063_abnormal_learning/memory/cond	1.96282385
10	MP0009745_abnormal_behavioral_response	1.93277997
11	MP0002734_abnormal_mechanical_nocicepti	1.82852934
12	MP0001346_abnormal_lacrimal_gland	1.74575116
13	MP0002272_abnormal_nervous_system	1.67140840
14	MP0005187_abnormal_penis_morphology	1.65723745
15	MP0004233_abnormal_muscle_weight	1.61702377
16	MP0001486_abnormal_startle_reflex	1.60203715
17	MP0003705_abnormal_hypodermis_morpholog	1.59663248
18	MP0002249_abnormal_larynx_morphology	1.59563697
19	MP0001968_abnormal_touch/_nociception	1.59263112
20	MP0002572_abnormal_emotion/affect_behav	1.58734606
21	MP0000537_abnormal_urethra_morphology	1.54938171
22	MP0000778_abnormal_nervous_system	1.52827276
23	MP0009053_abnormal_anal_canal	1.49588850
24	MP0002234_abnormal_pharynx_morphology	1.48554464
25	MP0010030_abnormal_orbit_morphology	1.46543781
26	MP0003111_abnormal_nucleus_morphology	1.44220615
27	MP0004811_abnormal_neuron_physiology	1.40243310
28	MP0000534_abnormal_ureter_morphology	1.32290526
29	MP0003385_abnormal_body_wall	1.31788285
30	MP0000751_myopathy	1.30766775
31	MP0009780_abnormal_chondrocyte_physiolo	1.27353176
32	MP0001299_abnormal_eye_distance/	1.27300765
33	MP0000955_abnormal_spinal_cord	1.27089612
34	MP0002735_abnormal_chemical_nociception	1.26090760
35	MP0009250_abnormal_appendicular_skeleto	1.24320745
36	MP0002736_abnormal_nociception_after	1.21736619
37	MP0010094_abnormal_chromosome_stability	1.19736329
38	MP0003942_abnormal_urinary_system	1.18469632
39	MP0008569_lethality_at_weaning	1.13794776
40	MP0003879_abnormal_hair_cell	1.13694167
41	MP0002184_abnormal_innervation	1.11966925
42	MP0003861_abnormal_nervous_system	1.10634635
43	MP0003937_abnormal_limbs/digits/tail_de	1.10253830
44	MP0003283_abnormal_digestive_organ	1.10097611
45	MP0008438_abnormal_cutaneous_collagen	1.09000551
46	MP0003123_paternal_imprinting	1.08911969
47	MP0002882_abnormal_neuron_morphology	1.07621014
48	MP0003693_abnormal_embryo_hatching	1.06256049
49	MP0005503_abnormal_tendon_morphology	1.06149616
50	MP0003329_amyloid_beta_deposits	1.06127439
51	MP0002067_abnormal_sensory_capabilities	1.05762921
52	MP0001502_abnormal_circadian_rhythm	1.05709525
53	MP0000049_abnormal_middle_ear	1.05696883
54	MP0002152_abnormal_brain_morphology	1.04729267
55	MP0002160_abnormal_reproductive_system	1.01823588
56	MP0005171_absent_coat_pigmentation	1.01318209
57	MP0002066_abnormal_motor_capabilities/c	1.01276749
58	MP0008932_abnormal_embryonic_tissue	0.98116191
59	MP0003077_abnormal_cell_cycle	0.97647738
60	MP0002557_abnormal_social/conspecific_i	0.95631655
61	MP0001970_abnormal_pain_threshold	0.95281421
62	MP0008058_abnormal_DNA_repair	0.93734046
63	MP0000733_abnormal_muscle_development	0.92836497
64	MP0005409_darkened_coat_color	0.89794789
65	MP0003119_abnormal_digestive_system	0.89066660
66	MP0004272_abnormal_basement_membrane	0.88491235
67	MP0001177_atelectasis	0.88074335
68	MP0005386_behavior/neurological_phenoty	0.86282191
69	MP0004924_abnormal_behavior	0.86282191
70	MP0001501_abnormal_sleep_pattern	0.86185003
71	MP0000749_muscle_degeneration	0.85393170
72	MP0002733_abnormal_thermal_nociception	0.85017569
73	MP0001529_abnormal_vocalization	0.84918380
74	MP0006276_abnormal_autonomic_nervous	0.84913838
75	MP0002233_abnormal_nose_morphology	0.84275898
76	MP0001440_abnormal_grooming_behavior	0.84038890
77	MP0010368_abnormal_lymphatic_system	0.84023698
78	MP0003136_yellow_coat_color	0.83043364
79	MP0001188_hyperpigmentation	0.83029868
80	MP0000566_synostosis	0.82222838
81	MP0000428_abnormal_craniofacial_morphol	0.81986509
82	MP0000678_abnormal_parathyroid_gland	0.81021030
83	MP0008057_abnormal_DNA_replication	0.80894438
84	MP0003950_abnormal_plasma_membrane	0.80335815
85	MP0001348_abnormal_lacrimal_gland	0.79140641
86	MP0005257_abnormal_intraocular_pressure	0.78742121
87	MP0003633_abnormal_nervous_system	0.78691855
88	MP0002081_perinatal_lethality	0.78564443
89	MP0002114_abnormal_axial_skeleton	0.78445840
90	MP0003890_abnormal_embryonic-extraembry	0.78066125
91	MP0003631_nervous_system_phenotype	0.75962960
92	MP0000631_abnormal_neuroendocrine_gland	0.75811584
93	MP0003935_abnormal_craniofacial_develop	0.75745090
94	MP0002084_abnormal_developmental_patter	0.75682000
95	MP0005670_abnormal_white_adipose	0.74811504
96	MP0003755_abnormal_palate_morphology	0.74619477
97	MP0000759_abnormal_skeletal_muscle	0.73444085
98	MP0000579_abnormal_nail_morphology	0.72085336
99	MP0002697_abnormal_eye_size	0.71547132
100	MP0000003_abnormal_adipose_tissue	0.71321985

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	3.67360005
2	Focal motor seizures (HP:0011153)	3.39863966
3	Epileptic encephalopathy (HP:0200134)	2.84488150
4	Focal seizures (HP:0007359)	2.81761152
5	Atonic seizures (HP:0010819)	2.73800066
6	Febrile seizures (HP:0002373)	2.53446608
7	Insomnia (HP:0100785)	2.43846130
8	Cerebral hypomyelination (HP:0006808)	2.37371838
9	Premature rupture of membranes (HP:0001788)	2.35660457
10	Abnormality of the phalanges of the hallux (HP:0010057)	2.34088739
11	Action tremor (HP:0002345)	2.23428969
12	Transposition of the great arteries (HP:0001669)	2.23250305
13	Abnormal connection of the cardiac segments (HP:0011545)	2.23250305
14	Abnormal ventriculo-arterial connection (HP:0011563)	2.23250305
15	Truncal ataxia (HP:0002078)	2.22494572
16	Hyperacusis (HP:0010780)	2.20541770
17	Abnormal number of incisors (HP:0011064)	2.14309699
18	Supranuclear gaze palsy (HP:0000605)	2.10415853
19	Protrusio acetabuli (HP:0003179)	2.08962077
20	Single umbilical artery (HP:0001195)	2.06987080
21	Abnormality of the fetal cardiovascular system (HP:0010948)	2.06987080
22	Abnormal umbilical cord blood vessels (HP:0011403)	2.06987080
23	Ulnar bowing (HP:0003031)	2.05302908
24	Dysmetric saccades (HP:0000641)	2.04707373
25	Shallow orbits (HP:0000586)	2.01526278
26	Poor eye contact (HP:0000817)	1.98850125
27	Birth length less than 3rd percentile (HP:0003561)	1.97654689
28	Amblyopia (HP:0000646)	1.97517956
29	Spinal rigidity (HP:0003306)	1.95753416
30	Generalized tonic-clonic seizures (HP:0002069)	1.95314940
31	Septate vagina (HP:0001153)	1.88474507
32	Spastic gait (HP:0002064)	1.87345325
33	Epileptiform EEG discharges (HP:0011182)	1.87243552
34	Obstructive sleep apnea (HP:0002870)	1.85312831
35	Preauricular pit (HP:0004467)	1.84852678
36	Periauricular skin pits (HP:0100277)	1.84852678
37	Dysmetria (HP:0001310)	1.84798305
38	Annular pancreas (HP:0001734)	1.84312428
39	Lower limb amyotrophy (HP:0007210)	1.81323192
40	Broad distal phalanx of finger (HP:0009836)	1.81302179
41	Turricephaly (HP:0000262)	1.80850673
42	Depression (HP:0000716)	1.80807273
43	Increased nuchal translucency (HP:0010880)	1.80458234
44	Hydroureter (HP:0000072)	1.78127857
45	Overriding aorta (HP:0002623)	1.77837289
46	Absence seizures (HP:0002121)	1.77014477
47	Urinary urgency (HP:0000012)	1.75185224
48	Abnormality of the umbilical cord (HP:0010881)	1.73244464
49	Abnormality of the lower motor neuron (HP:0002366)	1.72993767
50	Renal duplication (HP:0000075)	1.72951837
51	Abnormality of dentin (HP:0010299)	1.72426363
52	EEG with generalized epileptiform discharges (HP:0011198)	1.71232860
53	Bladder diverticulum (HP:0000015)	1.63261909
54	Mild short stature (HP:0003502)	1.62381686
55	Abnormality of the astrocytes (HP:0100707)	1.62038600
56	Astrocytoma (HP:0009592)	1.62038600
57	Hypsarrhythmia (HP:0002521)	1.61796295
58	Urethral obstruction (HP:0000796)	1.61146322
59	Limb dystonia (HP:0002451)	1.61079500
60	Abnormality of cochlea (HP:0000375)	1.60722853
61	Hypoventilation (HP:0002791)	1.60307314
62	Sensory axonal neuropathy (HP:0003390)	1.59329627
63	Torticollis (HP:0000473)	1.57467901
64	Impaired smooth pursuit (HP:0007772)	1.57134811
65	Cerebral inclusion bodies (HP:0100314)	1.55427218
66	Preaxial foot polydactyly (HP:0001841)	1.54478532
67	Hypoplasia of the iris (HP:0007676)	1.53367897
68	Ankle contracture (HP:0006466)	1.53059976
69	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.52019415
70	Morphological abnormality of the inner ear (HP:0011390)	1.51689926
71	Dialeptic seizures (HP:0011146)	1.51643570
72	Bowel diverticulosis (HP:0005222)	1.51588463
73	Postural instability (HP:0002172)	1.50612699
74	Abnormality of the 4th metacarpal (HP:0010012)	1.50231789
75	Genu recurvatum (HP:0002816)	1.49784314
76	Urinary bladder sphincter dysfunction (HP:0002839)	1.49514399
77	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.48230170
78	Duplication of thumb phalanx (HP:0009942)	1.47978913
79	Premature skin wrinkling (HP:0100678)	1.47621442
80	Elfin facies (HP:0004428)	1.47588004
81	Ankle clonus (HP:0011448)	1.47533836
82	Congenital malformation of the right heart (HP:0011723)	1.47509999
83	Double outlet right ventricle (HP:0001719)	1.47509999
84	Skin pits (HP:0100276)	1.45704350
85	CNS hypomyelination (HP:0003429)	1.45580289
86	Calcaneovalgus deformity (HP:0001848)	1.45235967
87	Cutaneous finger syndactyly (HP:0010554)	1.45067327
88	Renovascular hypertension (HP:0100817)	1.44376146
89	Bradykinesia (HP:0002067)	1.44242604
90	Coronal craniosynostosis (HP:0004440)	1.44147412
91	Megalocornea (HP:0000485)	1.43466081
92	Flat cornea (HP:0007720)	1.42655824
93	Ectopic kidney (HP:0000086)	1.40636713
94	Abnormal social behavior (HP:0012433)	1.40238740
95	Impaired social interactions (HP:0000735)	1.40238740
96	High anterior hairline (HP:0009890)	1.40129600
97	Hammertoe (HP:0001765)	1.39669858
98	Deformed tarsal bones (HP:0008119)	1.39593139
99	Resting tremor (HP:0002322)	1.39102724
100	Pointed chin (HP:0000307)	1.38951679

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	3.44132310
2	PAK6	2.91785344
3	EPHA4	2.85851073
4	MARK1	2.82773850
5	LATS2	2.37217414
6	NTRK3	2.34937563
7	CDK12	2.26172758
8	MAP3K9	2.20141249
9	PRKD3	2.13320950
10	CAMK1G	1.97011621
11	ICK	1.83343182
12	BUB1	1.77603971
13	NTRK1	1.69905540
14	ARAF	1.61332438
15	BRSK1	1.58376769
16	EEF2K	1.58255307
17	NTRK2	1.51771060
18	UHMK1	1.50371327
19	DAPK2	1.49450990
20	CASK	1.46609398
21	PLK2	1.44855323
22	KSR2	1.44406118
23	STK38	1.40439792
24	MINK1	1.37916866
25	CDC7	1.34439312
26	TSSK6	1.29438435
27	SRPK1	1.24930533
28	CCNB1	1.18372978
29	TTK	1.15332348
30	LATS1	1.15158203
31	WEE1	1.12576588
32	PDGFRA	1.10657505
33	CAMK1D	1.08966435
34	RIPK1	1.08179143
35	CAMK1	1.06652854
36	CAMKK1	1.05965155
37	CHEK2	1.05847585
38	CDK15	1.04822218
39	CDK18	1.01506180
40	PHKG1	1.00543408
41	PHKG2	1.00543408
42	CDK11A	1.00370931
43	PDK2	0.95931016
44	CDK14	0.92083564
45	BRAF	0.92074052
46	KSR1	0.90905379
47	PRKCG	0.88336220
48	CAMK4	0.88061152
49	CDK5	0.87374213
50	PBK	0.86110298
51	WNK1	0.83909802
52	PLK1	0.81468223
53	SIK2	0.78632706
54	TRIM28	0.78050902
55	TRIB3	0.78006334
56	PAK2	0.77078906
57	MAPKAPK5	0.75929868
58	CAMK2B	0.75764670
59	BRD4	0.75056358
60	AURKA	0.74808280
61	RAF1	0.72906398
62	MAP3K4	0.72719936
63	PTK2	0.72097322
64	PINK1	0.71725345
65	STK16	0.69798422
66	MAP2K7	0.69236562
67	DAPK1	0.68982040
68	TYRO3	0.67909210
69	CDK8	0.67575204
70	WNK4	0.67268124
71	ERBB4	0.65647934
72	MTOR	0.65501586
73	PLK3	0.65431390
74	IRAK3	0.62974171
75	NEK1	0.62588647
76	CAMKK2	0.61470224
77	CHEK1	0.60398263
78	CSNK1A1L	0.60293813
79	MAPK10	0.59994267
80	LIMK1	0.59517459
81	MKNK2	0.57318596
82	CAMK2G	0.55850789
83	ALK	0.55286871
84	EPHB2	0.55231257
85	CAMK2A	0.55101097
86	AKT2	0.53321288
87	CSNK1E	0.52665045
88	CDK2	0.51030463
89	DDR2	0.50816325
90	CDK1	0.49917673
91	PRPF4B	0.49753224
92	MAP3K10	0.49174237
93	CSNK1G3	0.47149333
94	ATR	0.45632349
95	CSNK1G1	0.45446846
96	CDK3	0.45095862
97	MAP2K4	0.44925317
98	CSNK1G2	0.42782950
99	PKN1	0.41749613
100	GRK5	0.41580638

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	2.79088617
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.60820206
3	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.50517407
4	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.80605630
5	Amphetamine addiction_Homo sapiens_hsa05031	1.80028260
6	GABAergic synapse_Homo sapiens_hsa04727	1.75676530
7	Long-term potentiation_Homo sapiens_hsa04720	1.70536154
8	Morphine addiction_Homo sapiens_hsa05032	1.69975301
9	Circadian entrainment_Homo sapiens_hsa04713	1.64655588
10	Glutamatergic synapse_Homo sapiens_hsa04724	1.63629705
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.62599187
12	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.59258611
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.55201954
14	Cocaine addiction_Homo sapiens_hsa05030	1.54485154
15	Insulin secretion_Homo sapiens_hsa04911	1.46539651
16	Dopaminergic synapse_Homo sapiens_hsa04728	1.46003567
17	DNA replication_Homo sapiens_hsa03030	1.43611616
18	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.41704061
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41338794
20	Cell cycle_Homo sapiens_hsa04110	1.34843948
21	Oocyte meiosis_Homo sapiens_hsa04114	1.33790258
22	Glioma_Homo sapiens_hsa05214	1.23947788
23	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.23603727
24	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.23133240
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.19453686
26	Hippo signaling pathway_Homo sapiens_hsa04390	1.18394796
27	Gastric acid secretion_Homo sapiens_hsa04971	1.14752219
28	Gap junction_Homo sapiens_hsa04540	1.12330298
29	Cholinergic synapse_Homo sapiens_hsa04725	1.11872634
30	Melanogenesis_Homo sapiens_hsa04916	1.06530720
31	cAMP signaling pathway_Homo sapiens_hsa04024	0.99486882
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98967505
33	Estrogen signaling pathway_Homo sapiens_hsa04915	0.97811132
34	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.96767187
35	Calcium signaling pathway_Homo sapiens_hsa04020	0.95240405
36	Arginine and proline metabolism_Homo sapiens_hsa00330	0.94731812
37	RNA transport_Homo sapiens_hsa03013	0.93471316
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.92503556
39	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.91871367
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.91152988
41	One carbon pool by folate_Homo sapiens_hsa00670	0.90178590
42	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.88324906
43	Mismatch repair_Homo sapiens_hsa03430	0.88136525
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.88074525
45	Salivary secretion_Homo sapiens_hsa04970	0.87654837
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.87649167
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.87013605
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.86548806
49	Basal cell carcinoma_Homo sapiens_hsa05217	0.85160276
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.84917513
51	Wnt signaling pathway_Homo sapiens_hsa04310	0.84914274
52	Taste transduction_Homo sapiens_hsa04742	0.84363607
53	Sulfur relay system_Homo sapiens_hsa04122	0.82530858
54	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.82071977
55	Olfactory transduction_Homo sapiens_hsa04740	0.80182097
56	ErbB signaling pathway_Homo sapiens_hsa04012	0.79591225
57	Circadian rhythm_Homo sapiens_hsa04710	0.79464515
58	Folate biosynthesis_Homo sapiens_hsa00790	0.78903565
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.77805688
60	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.76742995
61	Arginine biosynthesis_Homo sapiens_hsa00220	0.76610977
62	Axon guidance_Homo sapiens_hsa04360	0.75409962
63	RNA polymerase_Homo sapiens_hsa03020	0.75026700
64	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.74529022
65	Prion diseases_Homo sapiens_hsa05020	0.73971467
66	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.71922976
67	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.70997937
68	Long-term depression_Homo sapiens_hsa04730	0.70278485
69	GnRH signaling pathway_Homo sapiens_hsa04912	0.70173774
70	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.70124465
71	Lysine degradation_Homo sapiens_hsa00310	0.69872850
72	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69048744
73	ECM-receptor interaction_Homo sapiens_hsa04512	0.67956256
74	Vibrio cholerae infection_Homo sapiens_hsa05110	0.66060492
75	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.65954729
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65394834
77	Base excision repair_Homo sapiens_hsa03410	0.63957037
78	Glucagon signaling pathway_Homo sapiens_hsa04922	0.63617137
79	AMPK signaling pathway_Homo sapiens_hsa04152	0.63423501
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63275645
81	MicroRNAs in cancer_Homo sapiens_hsa05206	0.62547718
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.61983269
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.60417705
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.60416812
85	Type II diabetes mellitus_Homo sapiens_hsa04930	0.59070703
86	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.58793485
87	Spliceosome_Homo sapiens_hsa03040	0.58758600
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.58691227
89	Nucleotide excision repair_Homo sapiens_hsa03420	0.57805934
90	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.55752914
91	Melanoma_Homo sapiens_hsa05218	0.53796130
92	Alcoholism_Homo sapiens_hsa05034	0.53774861
93	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.52086633
94	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49755509
95	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.49294105
96	Fanconi anemia pathway_Homo sapiens_hsa03460	0.49025035
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48774336
98	Serotonergic synapse_Homo sapiens_hsa04726	0.47663384
99	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.47472102
100	mTOR signaling pathway_Homo sapiens_hsa04150	0.46919051

C17ORF51

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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