C17ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.16515095
2negative regulation of cell killing (GO:0031342)6.16515095
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.07123075
4positive regulation of gamma-delta T cell activation (GO:0046645)5.94799284
5antigen processing and presentation of endogenous antigen (GO:0019883)5.90810143
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.88734928
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.63947644
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.88865448
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.88865448
10modulation by symbiont of host immune response (GO:0052553)4.88865448
11positive regulation by symbiont of host defense response (GO:0052509)4.88865448
12modulation by symbiont of host defense response (GO:0052031)4.88865448
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.88865448
14detection of bacterium (GO:0016045)4.60337946
15regulation of B cell receptor signaling pathway (GO:0050855)4.58157733
16detection of other organism (GO:0098543)4.55364797
17leukocyte aggregation (GO:0070486)4.51254772
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44869279
19immunoglobulin mediated immune response (GO:0016064)4.37711738
20neutrophil activation involved in immune response (GO:0002283)4.37395100
21regulation of gamma-delta T cell activation (GO:0046643)4.36947903
22macrophage activation involved in immune response (GO:0002281)4.28986678
23response to type I interferon (GO:0034340)3.99436948
24type I interferon signaling pathway (GO:0060337)3.98985744
25cellular response to type I interferon (GO:0071357)3.98985744
26regulation of gamma-delta T cell differentiation (GO:0045586)3.95941420
27response to peptidoglycan (GO:0032494)3.93907774
28negative regulation of interleukin-12 production (GO:0032695)3.89752029
29negative regulation of lymphocyte mediated immunity (GO:0002707)3.89709839
30response to interleukin-15 (GO:0070672)3.88559370
31B cell receptor signaling pathway (GO:0050853)3.88060388
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.86003151
33regulation of interferon-beta biosynthetic process (GO:0045357)3.82941147
34negative thymic T cell selection (GO:0045060)3.81657309
35positive thymic T cell selection (GO:0045059)3.73503072
36detection of external biotic stimulus (GO:0098581)3.70315703
37negative T cell selection (GO:0043383)3.65713147
38cellular extravasation (GO:0045123)3.61670802
39respiratory burst (GO:0045730)3.61142573
40regulation of B cell differentiation (GO:0045577)3.60863434
41negative regulation of leukocyte mediated immunity (GO:0002704)3.60552640
42positive regulation of B cell differentiation (GO:0045579)3.56593802
43cellular response to interleukin-15 (GO:0071350)3.55765155
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.53922155
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53079160
46interferon-gamma-mediated signaling pathway (GO:0060333)3.52961575
47defense response to protozoan (GO:0042832)3.47657676
48neutrophil activation (GO:0042119)3.43413749
49B cell mediated immunity (GO:0019724)3.40239723
50regulation of T cell tolerance induction (GO:0002664)3.39791686
51germinal center formation (GO:0002467)3.38306527
52negative regulation of T cell mediated immunity (GO:0002710)3.37751364
53T cell migration (GO:0072678)3.37352969
54thymic T cell selection (GO:0045061)3.36686128
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33739164
56response to host immune response (GO:0052572)3.33739164
57positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.32933027
58regulation of antigen processing and presentation (GO:0002577)3.32074426
59T cell selection (GO:0045058)3.30997364
60negative regulation of phagocytosis (GO:0050765)3.30944429
61myeloid cell activation involved in immune response (GO:0002275)3.28568099
62NIK/NF-kappaB signaling (GO:0038061)3.27952810
63regulation of mast cell degranulation (GO:0043304)3.27862810
64positive regulation of antigen processing and presentation (GO:0002579)3.24790823
65regulation of alpha-beta T cell proliferation (GO:0046640)3.24790716
66negative regulation of erythrocyte differentiation (GO:0045647)3.23537353
67antigen processing and presentation via MHC class Ib (GO:0002475)3.23332432
68negative regulation of innate immune response (GO:0045824)3.23271245
69response to muramyl dipeptide (GO:0032495)3.22095607
70detection of biotic stimulus (GO:0009595)3.22081309
71response to protozoan (GO:0001562)3.19421125
72regulation of T cell mediated cytotoxicity (GO:0001914)3.17587828
73regulation of natural killer cell mediated immunity (GO:0002715)3.16036916
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.16036916
75granulocyte activation (GO:0036230)3.15208074
76positive regulation of T cell mediated cytotoxicity (GO:0001916)3.11984474
77positive T cell selection (GO:0043368)3.11728757
78leukocyte migration involved in inflammatory response (GO:0002523)3.11215753
79regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10400388
80microglial cell activation (GO:0001774)3.09524596
81negative regulation of T-helper cell differentiation (GO:0045623)3.08815064
82negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08815064
83regulation of myeloid leukocyte mediated immunity (GO:0002886)3.08639355
84response to host (GO:0075136)3.07719392
85response to host defenses (GO:0052200)3.07719392
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07719392
87tolerance induction (GO:0002507)3.06186500
88regulation of tolerance induction (GO:0002643)3.05798164
89detection of molecule of bacterial origin (GO:0032490)3.05036791
90regulation of T-helper 2 cell differentiation (GO:0045628)3.02751870
91negative regulation of alpha-beta T cell activation (GO:0046636)2.99633739
92regulation of mast cell activation involved in immune response (GO:0033006)2.96260738
93regulation of regulatory T cell differentiation (GO:0045589)2.95583899
94positive regulation of interferon-alpha production (GO:0032727)2.95140480
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.94574049
96leukocyte degranulation (GO:0043299)2.92338251
97regulation of leukocyte degranulation (GO:0043300)2.91673250
98negative regulation of cytokine production involved in immune response (GO:0002719)2.88931144
99macrophage activation (GO:0042116)2.87491279
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.86211607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.22005459
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.49745896
3VDR_21846776_ChIP-Seq_THP-1_Human3.48137186
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.34180294
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.22520884
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.20151313
7MYC_22102868_ChIP-Seq_BL_Human3.05137847
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76734731
9VDR_24763502_ChIP-Seq_THP-1_Human2.68961627
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.57700336
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55461887
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.54373671
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.52958307
14* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.51472271
15* MAF_26560356_Chip-Seq_TH1_Human2.51405187
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.44488286
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.35636020
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34657244
19SPI1_23547873_ChIP-Seq_NB4_Human2.33311683
20* UTX_26944678_Chip-Seq_JUKART_Human2.32604131
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.24552183
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20072197
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20067279
24RUNX_20019798_ChIP-Seq_JUKART_Human2.14941632
25MYB_26560356_Chip-Seq_TH2_Human2.13085963
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.12837826
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10497349
28SPI1_23127762_ChIP-Seq_K562_Human2.10310421
29MAF_26560356_Chip-Seq_TH2_Human2.09817533
30* LXR_22292898_ChIP-Seq_THP-1_Human2.05363241
31SCL_19346495_ChIP-Seq_HPC-7_Human2.05123131
32TCF7_22412390_ChIP-Seq_EML_Mouse2.01326753
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98332357
34KDM2B_26808549_Chip-Seq_DND41_Human1.97364896
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92052459
36MYB_26560356_Chip-Seq_TH1_Human1.91778227
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.90504443
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.90243870
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86979284
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85420106
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.79325796
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75874103
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75576555
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71947087
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67547167
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66167411
47* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66139847
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.64111456
49BCL6_27268052_Chip-Seq_Bcells_Human1.55538290
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52806921
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52320946
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.47712071
53GATA3_27048872_Chip-Seq_THYMUS_Human1.47474018
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44129103
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42870302
56BCOR_27268052_Chip-Seq_Bcells_Human1.42737462
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39270844
58* ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39142365
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38971660
60PU.1_20513432_ChIP-Seq_Bcells_Mouse1.38055931
61CIITA_25753668_ChIP-Seq_RAJI_Human1.37189800
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34568654
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34381475
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33700560
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33312054
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32618190
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.31516415
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31477242
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31334988
70P68_20966046_ChIP-Seq_HELA_Human1.26590627
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25746680
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25474240
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23791437
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22397373
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22301018
76STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21424222
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.21034270
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.19912581
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19587306
80RACK7_27058665_Chip-Seq_MCF-7_Human1.16984680
81VDR_24787735_ChIP-Seq_THP-1_Human1.15991042
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15457232
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13537614
84NCOR1_26117541_ChIP-Seq_K562_Human1.10245988
85CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08395094
86GATA3_26560356_Chip-Seq_TH2_Human1.03085980
87VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02206607
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02176073
89CTCF_26484167_Chip-Seq_Bcells_Mouse1.01678437
90PU_27001747_Chip-Seq_BMDM_Mouse1.00650682
91SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00314667
92SMC4_20622854_ChIP-Seq_HELA_Human1.00225599
93TET1_21451524_ChIP-Seq_MESCs_Mouse0.99253405
94GATA1_19941826_ChIP-Seq_K562_Human0.98908256
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98069501
96CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97404523
97RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96392942
98E2F1_20622854_ChIP-Seq_HELA_Human0.94907703
99GATA1_22025678_ChIP-Seq_K562_Human0.93360814
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90729169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.17926458
2MP0001835_abnormal_antigen_presentation3.99911808
3MP0003724_increased_susceptibility_to3.94932668
4MP0003303_peritoneal_inflammation3.50230957
5MP0005671_abnormal_response_to3.47966193
6MP0005387_immune_system_phenotype3.24250000
7MP0001790_abnormal_immune_system3.24250000
8MP0000685_abnormal_immune_system3.22775636
9MP0001800_abnormal_humoral_immune3.14214426
10MP0005000_abnormal_immune_tolerance3.02496227
11MP0005025_abnormal_response_to2.97665288
12MP0002419_abnormal_innate_immunity2.94587082
13MP0003763_abnormal_thymus_physiology2.86568369
14MP0009785_altered_susceptibility_to2.84160711
15MP0002723_abnormal_immune_serum2.73306053
16MP0002452_abnormal_antigen_presenting2.66069979
17MP0002420_abnormal_adaptive_immunity2.65335473
18MP0001819_abnormal_immune_cell2.62830527
19MP0002148_abnormal_hypersensitivity_rea2.44492618
20MP0006082_CNS_inflammation2.42722706
21MP0003300_gastrointestinal_ulcer2.32527719
22MP0002398_abnormal_bone_marrow2.11870166
23MP0009333_abnormal_splenocyte_physiolog2.10155653
24MP0000716_abnormal_immune_system2.06970159
25MP0010155_abnormal_intestine_physiology2.05669010
26MP0001533_abnormal_skeleton_physiology2.01922845
27MP0003172_abnormal_lysosome_physiology2.01587517
28MP0002405_respiratory_system_inflammati2.01504590
29MP0005464_abnormal_platelet_physiology2.00269520
30MP0009278_abnormal_bone_marrow1.95894926
31MP0005058_abnormal_lysosome_morphology1.87110771
32MP0008260_abnormal_autophagy1.86304631
33MP0003191_abnormal_cellular_cholesterol1.84635279
34MP0001845_abnormal_inflammatory_respons1.82007044
35MP0000689_abnormal_spleen_morphology1.77047150
36MP0002396_abnormal_hematopoietic_system1.74130168
37MP0003866_abnormal_defecation1.72865936
38MP0002722_abnormal_immune_system1.72283060
39MP0004947_skin_inflammation1.72083600
40MP0002429_abnormal_blood_cell1.67861872
41MP0000703_abnormal_thymus_morphology1.60817899
42MP0008469_abnormal_protein_level1.52964668
43MP0003183_abnormal_peptide_metabolism1.52458333
44MP0001873_stomach_inflammation1.52183169
45MP0000465_gastrointestinal_hemorrhage1.47751480
46MP0005310_abnormal_salivary_gland1.45289273
47MP0004381_abnormal_hair_follicle1.42477079
48MP0009764_decreased_sensitivity_to1.31617623
49MP0000858_altered_metastatic_potential1.30946660
50MP0001545_abnormal_hematopoietic_system1.22638816
51MP0005397_hematopoietic_system_phenotyp1.22638816
52MP0005451_abnormal_body_composition1.21541693
53MP0002132_abnormal_respiratory_system1.19352039
54MP0004510_myositis1.17982541
55MP0002998_abnormal_bone_remodeling1.14853227
56MP0005075_abnormal_melanosome_morpholog1.13402455
57MP0000490_abnormal_crypts_of1.09342246
58MP0002166_altered_tumor_susceptibility1.06663722
59MP0001663_abnormal_digestive_system1.02218381
60MP0003075_altered_response_to1.01902684
61MP0002933_joint_inflammation1.01322116
62MP0009840_abnormal_foam_cell1.01213661
63MP0001851_eye_inflammation0.94408373
64MP0001853_heart_inflammation0.93763401
65MP0003828_pulmonary_edema0.93659530
66MP0005166_decreased_susceptibility_to0.91093356
67MP0004883_abnormal_blood_vessel0.90153799
68MP0004808_abnormal_hematopoietic_stem0.87765600
69MP0002277_abnormal_respiratory_mucosa0.86084847
70MP0000015_abnormal_ear_pigmentation0.85620554
71MP0001986_abnormal_taste_sensitivity0.85419018
72MP0000604_amyloidosis0.84589989
73MP0005390_skeleton_phenotype0.84347989
74MP0009763_increased_sensitivity_to0.84127763
75MP0003806_abnormal_nucleotide_metabolis0.83041109
76MP0002138_abnormal_hepatobiliary_system0.81475181
77MP0000343_altered_response_to0.78935667
78MP0003448_altered_tumor_morphology0.76192791
79MP0003690_abnormal_glial_cell0.75094180
80MP0003045_fibrosis0.72486861
81MP0005164_abnormal_response_to0.69977880
82MP0002019_abnormal_tumor_incidence0.66677757
83MP0003795_abnormal_bone_structure0.66080751
84MP0002006_tumorigenesis0.64699921
85MP0000249_abnormal_blood_vessel0.64034269
86MP0009765_abnormal_xenobiotic_induced0.63534378
87MP0008874_decreased_physiological_sensi0.62392393
88MP0005381_digestive/alimentary_phenotyp0.59232343
89MP0008004_abnormal_stomach_pH0.55649550
90MP0000609_abnormal_liver_physiology0.55619388
91MP0004858_abnormal_nervous_system0.54176222
92MP0005083_abnormal_biliary_tract0.54022470
93MP0002653_abnormal_ependyma_morphology0.53702881
94MP0003091_abnormal_cell_migration0.53191390
95MP0005076_abnormal_cell_differentiation0.52905028
96MP0000371_diluted_coat_color0.50931740
97MP0002693_abnormal_pancreas_physiology0.49223615
98MP0005319_abnormal_enzyme/_coenzyme0.49107835
99MP0003878_abnormal_ear_physiology0.46458165
100MP0005377_hearing/vestibular/ear_phenot0.46458165

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.23340879
2Recurrent abscess formation (HP:0002722)5.38848183
3Recurrent bacterial skin infections (HP:0005406)5.24879972
4Myositis (HP:0100614)5.08622713
5Abnormality of macrophages (HP:0004311)4.90126579
6Orchitis (HP:0100796)4.61583432
7Elevated erythrocyte sedimentation rate (HP:0003565)4.47997412
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.47357238
9Meningitis (HP:0001287)4.37395949
10Recurrent fungal infections (HP:0002841)4.36574924
11Mediastinal lymphadenopathy (HP:0100721)4.30885628
12Stomatitis (HP:0010280)4.27637424
13Retrobulbar optic neuritis (HP:0100654)4.26411002
14Optic neuritis (HP:0100653)4.26411002
15Recurrent gram-negative bacterial infections (HP:0005420)4.02658788
16Chronic obstructive pulmonary disease (HP:0006510)3.94900887
17Obstructive lung disease (HP:0006536)3.94900887
18Chronic mucocutaneous candidiasis (HP:0002728)3.92939212
19Recurrent cutaneous fungal infections (HP:0011370)3.92939212
20Panhypogammaglobulinemia (HP:0003139)3.84468646
21Increased IgE level (HP:0003212)3.83393852
22Recurrent skin infections (HP:0001581)3.81036793
23Gastrointestinal infarctions (HP:0005244)3.73525829
24Encephalitis (HP:0002383)3.73161612
25Vasculitis (HP:0002633)3.65473331
26Cellulitis (HP:0100658)3.58468254
27Agammaglobulinemia (HP:0004432)3.54483791
28Recurrent viral infections (HP:0004429)3.43856170
29Colitis (HP:0002583)3.33147381
30Inflammation of the large intestine (HP:0002037)3.31836693
31Gastrointestinal inflammation (HP:0004386)3.31601970
32Spontaneous hematomas (HP:0007420)3.27821012
33Gingivitis (HP:0000230)3.19176141
34Pustule (HP:0200039)3.11587545
35Pulmonary infiltrates (HP:0002113)3.10789002
36Urticaria (HP:0001025)3.08014080
37Chest pain (HP:0100749)3.06983831
38Keratoconjunctivitis sicca (HP:0001097)3.04290755
39Gastrointestinal stroma tumor (HP:0100723)3.01106468
40Lymphopenia (HP:0001888)2.97520342
41Increased IgM level (HP:0003496)2.93266440
42Hemoptysis (HP:0002105)2.92549500
43Prolonged bleeding time (HP:0003010)2.91242603
44Abnormality of T cells (HP:0002843)2.89657501
45T lymphocytopenia (HP:0005403)2.89329531
46Keratoconjunctivitis (HP:0001096)2.85800741
47Hypochromic anemia (HP:0001931)2.80075102
48Granulocytopenia (HP:0001913)2.78532547
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.78435073
50Abnormality of T cell number (HP:0011839)2.76030845
51Abnormality of T cell physiology (HP:0011840)2.75387051
52Petechiae (HP:0000967)2.64725867
53Osteomyelitis (HP:0002754)2.62725411
54Epistaxis (HP:0000421)2.60875546
55IgM deficiency (HP:0002850)2.59881945
56Leukocytosis (HP:0001974)2.59739295
57Hypergammaglobulinemia (HP:0010702)2.50550691
58Increased cerebral lipofuscin (HP:0011813)2.49984480
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.46790722
60Abnormality of glycolipid metabolism (HP:0010969)2.46790722
61Abnormality of liposaccharide metabolism (HP:0010968)2.46790722
62Sepsis (HP:0100806)2.45453685
63Systemic lupus erythematosus (HP:0002725)2.42862168
64Recurrent bronchitis (HP:0002837)2.41353381
65Abnormality of the pleura (HP:0002103)2.41028566
66Purpura (HP:0000979)2.40415681
67Hypochromic microcytic anemia (HP:0004840)2.38123476
68Recurrent sinusitis (HP:0011108)2.36954260
69Arterial thrombosis (HP:0004420)2.35243188
70Pulmonary embolism (HP:0002204)2.34812731
71Gingival bleeding (HP:0000225)2.34030289
72Dysostosis multiplex (HP:0000943)2.33533717
73Loss of speech (HP:0002371)2.31271012
74Anorexia (HP:0002039)2.29640129
75Restrictive lung disease (HP:0002091)2.27128095
76Recurrent pneumonia (HP:0006532)2.25251102
77Episodic fever (HP:0001954)2.24114746
78Emphysema (HP:0002097)2.23972486
79Eosinophilia (HP:0001880)2.23161220
80Recurrent lower respiratory tract infections (HP:0002783)2.22737288
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.22224457
82Papilloma (HP:0012740)2.21453995
83Verrucae (HP:0200043)2.21453995
84Hepatosplenomegaly (HP:0001433)2.18900082
85Abnormality of B cell number (HP:0010975)2.16746856
86Abnormality of the peritoneum (HP:0002585)2.16395677
87Chronic otitis media (HP:0000389)2.14009259
88Increased serum ferritin (HP:0003281)2.11529174
89Premature loss of primary teeth (HP:0006323)2.09533597
90Skin ulcer (HP:0200042)2.07658836
91Skin rash (HP:0000988)2.03278233
92Autoimmune thrombocytopenia (HP:0001973)2.03100623
93Viral hepatitis (HP:0006562)2.02939417
94Amyloidosis (HP:0011034)2.01114251
95Hypertensive crisis (HP:0100735)2.00735948
96IgG deficiency (HP:0004315)2.00105285
97Gangrene (HP:0100758)1.98809319
98Microcytic anemia (HP:0001935)1.98100808
99Arthralgia (HP:0002829)1.96599710
100Abnormality of iron homeostasis (HP:0011031)1.96540364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.55844793
2ERN14.09876194
3RIPK44.04999091
4TYK22.89399905
5BLK2.85629489
6IRAK42.80549750
7MAP2K32.52138946
8PRPF4B2.45176047
9TNK22.32423043
10GRK62.17100774
11CSK2.13920184
12FES2.11773678
13ZAP701.99421681
14BTK1.91440025
15TRIB31.91365933
16EPHB11.86653077
17JAK31.84692999
18TBK11.84324064
19TXK1.80654967
20SYK1.79759370
21MAP3K141.76476857
22MAP3K111.75974651
23IKBKE1.70300404
24KIT1.61288518
25SIK31.58306404
26HCK1.56710441
27CSF1R1.55994803
28MAP3K131.55947101
29SMG11.51077767
30TESK21.48469247
31SIK21.44815084
32TAOK11.40412841
33LYN1.37836429
34JAK11.35078308
35MAP3K31.33488645
36FGR1.33471499
37LCK1.23848221
38ITK1.19324647
39FGFR41.18882800
40MARK31.18339200
41TAOK31.11943907
42JAK21.08145968
43SIK11.07718321
44IKBKB1.05421287
45PRKD21.04252084
46CDC42BPA1.00192672
47MAP3K10.92352786
48TAOK20.91346135
49MARK20.90085479
50PDK10.87530379
51MATK0.82735933
52TEC0.82044141
53PTK60.77632236
54CDK190.75879173
55STK100.75333121
56PDPK10.75091999
57MAP3K100.74890855
58HIPK20.74739055
59MAPK120.72578469
60MAP3K70.72293946
61MAP2K60.68085601
62MAPK110.66686293
63PRKCQ0.66661440
64IRAK10.63577264
65LRRK20.62841337
66EPHA30.61116171
67YES10.59862034
68FYN0.56254116
69PKN20.53477519
70MAPK70.53464772
71KSR20.53303171
72CAMKK10.53151192
73KDR0.53000783
74CDK40.52941415
75TGFBR20.51634259
76FGFR30.49541226
77RPS6KL10.48116045
78RPS6KC10.48116045
79DYRK1B0.47776791
80MAP2K20.47316037
81IRAK30.46695357
82MAPKAPK20.44398315
83IRAK20.42824567
84RPS6KA60.40996555
85BMPR20.38245320
86PTK2B0.38052868
87PIM10.37407034
88PRKCH0.36638131
89STK110.35063163
90MAP3K80.33195073
91BMX0.32569371
92NLK0.31217099
93RET0.30384583
94MAP3K60.29056648
95RPS6KA20.28596678
96ICK0.27542584
97MAPK40.27413932
98PRKD10.26801684
99CHUK0.26521664
100MAPK30.22266802

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.22010926
2Allograft rejection_Homo sapiens_hsa053303.13083275
3Graft-versus-host disease_Homo sapiens_hsa053322.99544310
4Autoimmune thyroid disease_Homo sapiens_hsa053202.90628667
5Leishmaniasis_Homo sapiens_hsa051402.82127789
6Staphylococcus aureus infection_Homo sapiens_hsa051502.80023955
7Osteoclast differentiation_Homo sapiens_hsa043802.65637711
8B cell receptor signaling pathway_Homo sapiens_hsa046622.37262508
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.32285575
10Type I diabetes mellitus_Homo sapiens_hsa049402.23714444
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16921667
12Asthma_Homo sapiens_hsa053102.15038271
13Antigen processing and presentation_Homo sapiens_hsa046122.12097643
14Other glycan degradation_Homo sapiens_hsa005112.06636764
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05868808
16Tuberculosis_Homo sapiens_hsa051521.99016105
17Viral myocarditis_Homo sapiens_hsa054161.92939333
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.91838290
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87676260
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.86094875
21Measles_Homo sapiens_hsa051621.78841128
22Hematopoietic cell lineage_Homo sapiens_hsa046401.77883548
23Acute myeloid leukemia_Homo sapiens_hsa052211.69815893
24T cell receptor signaling pathway_Homo sapiens_hsa046601.66925742
25Toxoplasmosis_Homo sapiens_hsa051451.64356822
26Herpes simplex infection_Homo sapiens_hsa051681.62308714
27Influenza A_Homo sapiens_hsa051641.61258005
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.60712553
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49840126
30Chemokine signaling pathway_Homo sapiens_hsa040621.47647235
31Malaria_Homo sapiens_hsa051441.45775723
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.45759212
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.25653738
34TNF signaling pathway_Homo sapiens_hsa046681.23225996
35Phagosome_Homo sapiens_hsa041451.22812087
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17710079
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16894890
38Hepatitis B_Homo sapiens_hsa051611.15752499
39Hepatitis C_Homo sapiens_hsa051601.14800935
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14403845
41Rheumatoid arthritis_Homo sapiens_hsa053231.13919731
42Legionellosis_Homo sapiens_hsa051341.06169856
43Pertussis_Homo sapiens_hsa051331.05334041
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.03202667
45Lysosome_Homo sapiens_hsa041421.01378342
46Non-small cell lung cancer_Homo sapiens_hsa052231.00143410
47African trypanosomiasis_Homo sapiens_hsa051430.99951071
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97713716
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.95754891
50Platelet activation_Homo sapiens_hsa046110.94905589
51Shigellosis_Homo sapiens_hsa051310.94380456
52Apoptosis_Homo sapiens_hsa042100.94224640
53Epstein-Barr virus infection_Homo sapiens_hsa051690.94192844
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89875739
55VEGF signaling pathway_Homo sapiens_hsa043700.86421529
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86153299
57Pancreatic cancer_Homo sapiens_hsa052120.84480309
58Chronic myeloid leukemia_Homo sapiens_hsa052200.84387927
59Notch signaling pathway_Homo sapiens_hsa043300.77405523
60Salmonella infection_Homo sapiens_hsa051320.76838920
61HTLV-I infection_Homo sapiens_hsa051660.73151232
62Viral carcinogenesis_Homo sapiens_hsa052030.68233013
63Prolactin signaling pathway_Homo sapiens_hsa049170.68117182
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67340693
65Endocytosis_Homo sapiens_hsa041440.66866557
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.66286883
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.60041025
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.58936164
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58680232
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57200678
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55603387
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53983585
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53573853
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.52537081
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.47170831
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44130402
77Choline metabolism in cancer_Homo sapiens_hsa052310.43220549
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41829350
79Renal cell carcinoma_Homo sapiens_hsa052110.40505016
80Insulin resistance_Homo sapiens_hsa049310.40255765
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39009519
82Colorectal cancer_Homo sapiens_hsa052100.37646112
83FoxO signaling pathway_Homo sapiens_hsa040680.37436450
84mTOR signaling pathway_Homo sapiens_hsa041500.36642362
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34267572
86Endometrial cancer_Homo sapiens_hsa052130.34254094
87GnRH signaling pathway_Homo sapiens_hsa049120.33915749
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32313086
89HIF-1 signaling pathway_Homo sapiens_hsa040660.31925376
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31170925
91Fructose and mannose metabolism_Homo sapiens_hsa000510.30649137
92MAPK signaling pathway_Homo sapiens_hsa040100.28819390
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28614346
94Inositol phosphate metabolism_Homo sapiens_hsa005620.28609741
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27021977
96Bladder cancer_Homo sapiens_hsa052190.26466271
97Systemic lupus erythematosus_Homo sapiens_hsa053220.26180755
98Rap1 signaling pathway_Homo sapiens_hsa040150.25115824
99Regulation of autophagy_Homo sapiens_hsa041400.24439851
100Prostate cancer_Homo sapiens_hsa052150.24178103

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