C17ORF67

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.71943533
2rRNA modification (GO:0000154)4.48370549
3cytidine metabolic process (GO:0046087)4.40831535
4cytidine catabolic process (GO:0006216)4.40831535
5cytidine deamination (GO:0009972)4.40831535
6rRNA methylation (GO:0031167)4.36326770
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92957778
8T cell migration (GO:0072678)3.87424651
9positive regulation of defense response to virus by host (GO:0002230)3.78001044
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.77002537
11piRNA metabolic process (GO:0034587)3.72447254
12regulation of chronic inflammatory response (GO:0002676)3.72059728
13negative T cell selection (GO:0043383)3.54778457
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.43679624
15positive regulation of alpha-beta T cell proliferation (GO:0046641)3.37662412
16regulation of immunoglobulin secretion (GO:0051023)3.33300175
17negative thymic T cell selection (GO:0045060)3.30386415
18positive regulation of T cell cytokine production (GO:0002726)3.27887718
19positive regulation of lymphocyte migration (GO:2000403)3.27847027
20signal complex assembly (GO:0007172)3.25065571
21regulation of T cell tolerance induction (GO:0002664)3.21335807
22viral transcription (GO:0019083)3.20993797
23positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.14600975
24GTP biosynthetic process (GO:0006183)3.13868008
25negative regulation of viral genome replication (GO:0045071)3.12974203
26regulation of interferon-alpha production (GO:0032647)3.12967753
27dendritic cell chemotaxis (GO:0002407)3.11666760
28negative regulation of type I interferon production (GO:0032480)3.10013147
29regulation of T-helper 1 cell differentiation (GO:0045625)3.09356021
30positive regulation of interleukin-2 production (GO:0032743)3.08446411
31positive regulation of tolerance induction (GO:0002645)3.07432679
32positive thymic T cell selection (GO:0045059)3.03823581
33cellular response to exogenous dsRNA (GO:0071360)3.03570676
34positive regulation of interferon-alpha production (GO:0032727)3.02114756
35DNA methylation involved in gamete generation (GO:0043046)3.00985362
36regulation of lymphocyte migration (GO:2000401)2.97744149
37positive regulation of T cell migration (GO:2000406)2.96740510
38regulation of defense response to virus by host (GO:0050691)2.94478570
39translational termination (GO:0006415)2.93118710
40positive T cell selection (GO:0043368)2.92105238
41male meiosis I (GO:0007141)2.91948145
42regulation of alpha-beta T cell proliferation (GO:0046640)2.91918325
43synapsis (GO:0007129)2.91151686
44ribosomal small subunit biogenesis (GO:0042274)2.90506437
45positive regulation of T cell differentiation in thymus (GO:0033089)2.90071488
46CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.86934923
47thymic T cell selection (GO:0045061)2.86738737
48positive regulation of T-helper 1 type immune response (GO:0002827)2.84915336
49lymphocyte chemotaxis (GO:0048247)2.84517884
50T cell lineage commitment (GO:0002360)2.82989629
51positive regulation of gamma-delta T cell activation (GO:0046645)2.81647879
52response to acidic pH (GO:0010447)2.80733686
53response to type I interferon (GO:0034340)2.80001089
54type I interferon signaling pathway (GO:0060337)2.79893312
55cellular response to type I interferon (GO:0071357)2.79893312
56regulation of T cell migration (GO:2000404)2.78579670
57NIK/NF-kappaB signaling (GO:0038061)2.75767045
58tolerance induction (GO:0002507)2.75166186
59regulation of B cell receptor signaling pathway (GO:0050855)2.74989543
60UTP biosynthetic process (GO:0006228)2.74484752
61negative regulation of lipid storage (GO:0010888)2.72041310
62positive regulation of granulocyte differentiation (GO:0030854)2.71753596
63histone H3-K36 demethylation (GO:0070544)2.71550305
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67282213
65regulation of T cell receptor signaling pathway (GO:0050856)2.66870895
66regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.66455682
67negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.61394071
68cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.61192251
69RNA destabilization (GO:0050779)2.60098581
70T cell selection (GO:0045058)2.59219017
71negative regulation by host of viral transcription (GO:0043922)2.57968416
72indolalkylamine metabolic process (GO:0006586)2.55864675
73positive regulation of interleukin-12 production (GO:0032735)2.55137550
74positive regulation of translational initiation (GO:0045948)2.54288855
75regulation of T-helper 1 type immune response (GO:0002825)2.54217261
76positive regulation of calcium-mediated signaling (GO:0050850)2.52415284
77UTP metabolic process (GO:0046051)2.52305158
78positive regulation of alpha-beta T cell activation (GO:0046635)2.51254385
79regulation of lymphocyte chemotaxis (GO:1901623)2.49461248
80chemokine-mediated signaling pathway (GO:0070098)2.49371587
81regulation of regulatory T cell differentiation (GO:0045589)2.48911412
82regulation of tolerance induction (GO:0002643)2.48181493
83translational elongation (GO:0006414)2.46976429
84Peyers patch development (GO:0048541)2.45177049
85mucosal-associated lymphoid tissue development (GO:0048537)2.45177049
86rRNA processing (GO:0006364)2.44232601
87regulation of alpha-beta T cell activation (GO:0046634)2.43920751
88negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.43856470
89protein targeting to ER (GO:0045047)2.43493008
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.42715345
91positive regulation of T cell apoptotic process (GO:0070234)2.42188153
92regulation of T cell cytokine production (GO:0002724)2.41789745
93positive regulation of T cell differentiation (GO:0045582)2.39897046
94positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.39803446
95positive regulation of isotype switching (GO:0045830)2.39605842
96viral life cycle (GO:0019058)2.38459803
97regulation of viral genome replication (GO:0045069)2.38258452
98regulation of RIG-I signaling pathway (GO:0039535)2.36969500
99regulation of interleukin-2 biosynthetic process (GO:0045076)2.36876619
100positive regulation of interferon-beta production (GO:0032728)2.36817588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.80385134
2E2F7_22180533_ChIP-Seq_HELA_Human4.63517426
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.11158460
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62070825
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.08005440
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07821002
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.92619931
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62507418
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62319034
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54158667
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53769228
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.50218704
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.46038708
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.43243016
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41825428
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.40283231
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36671223
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26532242
19VDR_23849224_ChIP-Seq_CD4+_Human2.25685763
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.25307217
21MYB_26560356_Chip-Seq_TH2_Human2.17391221
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15041516
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14929173
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.10340565
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.09942221
26MYC_22102868_ChIP-Seq_BL_Human2.06827605
27RUNX_20019798_ChIP-Seq_JUKART_Human1.97648841
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.96924950
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96642601
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92867887
31MAF_26560356_Chip-Seq_TH1_Human1.92435113
32VDR_21846776_ChIP-Seq_THP-1_Human1.87776968
33MYB_26560356_Chip-Seq_TH1_Human1.82369724
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79938335
35FOXP3_21729870_ChIP-Seq_TREG_Human1.77633239
36MAF_26560356_Chip-Seq_TH2_Human1.74832718
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.73039427
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.67627139
39DCP1A_22483619_ChIP-Seq_HELA_Human1.67064966
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.66602968
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66126858
42SCL_19346495_ChIP-Seq_HPC-7_Human1.64504242
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.60837171
44* UTX_26944678_Chip-Seq_JUKART_Human1.60707811
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59052609
46MYC_18940864_ChIP-ChIP_HL60_Human1.57809410
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56862864
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56375921
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55548460
50SPI1_23547873_ChIP-Seq_NB4_Human1.55043301
51* GATA3_27048872_Chip-Seq_THYMUS_Human1.52432771
52KDM5A_27292631_Chip-Seq_BREAST_Human1.52396889
53VDR_24763502_ChIP-Seq_THP-1_Human1.48106160
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47924671
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47617939
56XRN2_22483619_ChIP-Seq_HELA_Human1.46532878
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45268882
58CIITA_25753668_ChIP-Seq_RAJI_Human1.43791604
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.43394764
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40832505
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40631733
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38748697
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37176544
64GABP_19822575_ChIP-Seq_HepG2_Human1.34135840
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34085893
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34006522
67TTF2_22483619_ChIP-Seq_HELA_Human1.31389768
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31288749
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.28322871
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25807007
71GATA3_26560356_Chip-Seq_TH2_Human1.24498945
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24354543
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22973826
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21659492
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.19822896
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18969787
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17202441
78GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16670126
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16038543
80GATA1_22025678_ChIP-Seq_K562_Human1.10606272
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09501683
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08847147
83HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08512971
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05908919
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.05809584
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.05379658
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05103131
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04519281
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03791728
90ELK1_19687146_ChIP-ChIP_HELA_Human1.03602262
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01215815
92* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99436359
93STAT1_20625510_ChIP-Seq_HELA_Human0.98891557
94ZNF263_19887448_ChIP-Seq_K562_Human0.98812392
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98385824
96FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96331488
97TFEB_21752829_ChIP-Seq_HELA_Human0.95573077
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94523284
99VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93616328
100MYC_19079543_ChIP-ChIP_MESCs_Mouse0.93092029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.77274860
2MP0005671_abnormal_response_to3.36149101
3MP0003300_gastrointestinal_ulcer3.05572288
4MP0002148_abnormal_hypersensitivity_rea2.96276914
5MP0001800_abnormal_humoral_immune2.86811187
6MP0000685_abnormal_immune_system2.81411156
7MP0005387_immune_system_phenotype2.76686911
8MP0001790_abnormal_immune_system2.76686911
9MP0005000_abnormal_immune_tolerance2.75699880
10MP0009333_abnormal_splenocyte_physiolog2.54738810
11MP0009785_altered_susceptibility_to2.53492826
12MP0002723_abnormal_immune_serum2.41036416
13MP0003763_abnormal_thymus_physiology2.40902882
14MP0003436_decreased_susceptibility_to2.37824327
15MP0003866_abnormal_defecation2.29332266
16MP0002452_abnormal_antigen_presenting2.23477071
17MP0002420_abnormal_adaptive_immunity2.14866179
18MP0003693_abnormal_embryo_hatching2.14164248
19MP0002398_abnormal_bone_marrow2.14120130
20MP0001819_abnormal_immune_cell2.13460364
21MP0005025_abnormal_response_to2.09379927
22MP0010155_abnormal_intestine_physiology1.90359629
23MP0005310_abnormal_salivary_gland1.90271216
24MP0000716_abnormal_immune_system1.88934945
25MP0000689_abnormal_spleen_morphology1.88918725
26MP0006292_abnormal_olfactory_placode1.88726913
27MP0009379_abnormal_foot_pigmentation1.87582206
28MP0000703_abnormal_thymus_morphology1.82468879
29MP0004808_abnormal_hematopoietic_stem1.81653696
30MP0003724_increased_susceptibility_to1.77275416
31MP0001853_heart_inflammation1.75359283
32MP0008877_abnormal_DNA_methylation1.74324996
33MP0002722_abnormal_immune_system1.70793961
34MP0002396_abnormal_hematopoietic_system1.64272202
35MP0000604_amyloidosis1.64099446
36MP0004947_skin_inflammation1.63947656
37MP0002138_abnormal_hepatobiliary_system1.58391715
38MP0008007_abnormal_cellular_replicative1.55927226
39MP0009764_decreased_sensitivity_to1.55293622
40MP0002429_abnormal_blood_cell1.55037839
41MP0002419_abnormal_innate_immunity1.53475528
42MP0001845_abnormal_inflammatory_respons1.52087400
43MP0003303_peritoneal_inflammation1.44150076
44MP0002163_abnormal_gland_morphology1.43320905
45MP0005464_abnormal_platelet_physiology1.40363888
46MP0001873_stomach_inflammation1.40083827
47MP0003646_muscle_fatigue1.39169454
48MP0005389_reproductive_system_phenotype1.37316394
49MP0002405_respiratory_system_inflammati1.32471877
50MP0002019_abnormal_tumor_incidence1.31095859
51MP0001919_abnormal_reproductive_system1.28222429
52MP0002160_abnormal_reproductive_system1.25291496
53MP0002132_abnormal_respiratory_system1.24712491
54MP0002139_abnormal_hepatobiliary_system1.24147561
55MP0003786_premature_aging1.17655253
56MP0003448_altered_tumor_morphology1.17528715
57MP0002277_abnormal_respiratory_mucosa1.15194719
58MP0002210_abnormal_sex_determination1.14959011
59MP0000490_abnormal_crypts_of1.14866280
60MP0003329_amyloid_beta_deposits1.12058890
61MP0001542_abnormal_bone_strength1.11032843
62MP0010386_abnormal_urinary_bladder1.10393282
63MP0008469_abnormal_protein_level1.10223475
64MP0000343_altered_response_to1.03690950
65MP0003011_delayed_dark_adaptation0.98156881
66MP0006082_CNS_inflammation0.97660354
67MP0004957_abnormal_blastocyst_morpholog0.95252168
68MP0002006_tumorigenesis0.95197313
69MP0000678_abnormal_parathyroid_gland0.94961917
70MP0001929_abnormal_gametogenesis0.94033605
71MP0005451_abnormal_body_composition0.93467000
72MP0005076_abnormal_cell_differentiation0.92819357
73MP0008995_early_reproductive_senescence0.92798200
74MP0010094_abnormal_chromosome_stability0.90264841
75MP0003195_calcinosis0.90197727
76MP0009765_abnormal_xenobiotic_induced0.89904959
77MP0005410_abnormal_fertilization0.89235525
78MP0002332_abnormal_exercise_endurance0.86259217
79MP0001145_abnormal_male_reproductive0.85969015
80MP0001533_abnormal_skeleton_physiology0.83776236
81MP0000313_abnormal_cell_death0.82777178
82MP0006035_abnormal_mitochondrial_morpho0.82692204
83MP0004185_abnormal_adipocyte_glucose0.76260577
84MP0008058_abnormal_DNA_repair0.74862591
85MP0004233_abnormal_muscle_weight0.73081309
86MP0003806_abnormal_nucleotide_metabolis0.72864015
87MP0000653_abnormal_sex_gland0.71374386
88MP0009763_increased_sensitivity_to0.70290159
89MP0004381_abnormal_hair_follicle0.70163684
90MP0003077_abnormal_cell_cycle0.69051057
91MP0001191_abnormal_skin_condition0.67961708
92MP0005379_endocrine/exocrine_gland_phen0.67420613
93MP0002166_altered_tumor_susceptibility0.64199743
94MP0003111_abnormal_nucleus_morphology0.63957573
95MP0001348_abnormal_lacrimal_gland0.63300739
96MP0001663_abnormal_digestive_system0.61278684
97MP0010307_abnormal_tumor_latency0.58778288
98MP0008873_increased_physiological_sensi0.58762941
99MP0003698_abnormal_male_reproductive0.58520378
100MP0008057_abnormal_DNA_replication0.57229932

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)6.13697694
2IgG deficiency (HP:0004315)4.35981421
3Increased IgM level (HP:0003496)4.32433590
4Abnormality of DNA repair (HP:0003254)4.10196014
5IgA deficiency (HP:0002720)3.81432728
6Panhypogammaglobulinemia (HP:0003139)3.78558704
7Type I transferrin isoform profile (HP:0003642)3.43578980
8Mediastinal lymphadenopathy (HP:0100721)3.21415923
9Entropion (HP:0000621)3.16103344
10Recurrent viral infections (HP:0004429)3.02012316
11Porencephaly (HP:0002132)2.99913214
12Abnormal pupillary function (HP:0007686)2.98133262
13Abnormality of T cell physiology (HP:0011840)2.96107528
14Microvesicular hepatic steatosis (HP:0001414)2.95749069
15Elevated erythrocyte sedimentation rate (HP:0003565)2.92595653
16Radial bowing (HP:0002986)2.86080046
17Pulmonary infiltrates (HP:0002113)2.82902354
18Abnormality of T cells (HP:0002843)2.82589211
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.78822305
20Reticulocytopenia (HP:0001896)2.77832726
21Acute hepatic failure (HP:0006554)2.70274549
22Limb hypertonia (HP:0002509)2.64375189
23Squamous cell carcinoma (HP:0002860)2.64038141
24Abnormal protein glycosylation (HP:0012346)2.60554833
25Abnormal glycosylation (HP:0012345)2.60554833
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60554833
27Abnormal protein N-linked glycosylation (HP:0012347)2.60554833
28Hypertensive crisis (HP:0100735)2.59164540
29Pancytopenia (HP:0001876)2.56527828
30Agammaglobulinemia (HP:0004432)2.55609114
31Autoimmune hemolytic anemia (HP:0001890)2.53272596
32Chronic otitis media (HP:0000389)2.52372760
33Aplastic anemia (HP:0001915)2.50563961
34Abnormal number of erythroid precursors (HP:0012131)2.50164081
35Acute necrotizing encephalopathy (HP:0006965)2.47066297
363-Methylglutaconic aciduria (HP:0003535)2.46105225
37Abnormality of T cell number (HP:0011839)2.44123322
38Thrombocytosis (HP:0001894)2.43974696
39T lymphocytopenia (HP:0005403)2.42024842
40Absent thumb (HP:0009777)2.37653439
41Abnormality of cells of the erythroid lineage (HP:0012130)2.36794881
42Abnormality of B cell number (HP:0010975)2.35275787
43Gonadotropin excess (HP:0000837)2.29142026
44Abnormal mitochondria in muscle tissue (HP:0008316)2.28546889
45Short tibia (HP:0005736)2.24445441
46Poikiloderma (HP:0001029)2.23984076
47Severe visual impairment (HP:0001141)2.23315525
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22999041
49Abnormality of the prostate (HP:0008775)2.21249670
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.18407792
51Increased intramyocellular lipid droplets (HP:0012240)2.17936014
52IgM deficiency (HP:0002850)2.17101077
53Testicular atrophy (HP:0000029)2.16268440
54B lymphocytopenia (HP:0010976)2.13776963
55Fibular hypoplasia (HP:0003038)2.12618731
56Meningitis (HP:0001287)2.08488873
57Clumsiness (HP:0002312)2.04300966
58Posterior subcapsular cataract (HP:0007787)2.00348183
59Type II lissencephaly (HP:0007260)2.00215688
60Recurrent bronchitis (HP:0002837)1.99857941
61Encephalitis (HP:0002383)1.99532869
62Renal Fanconi syndrome (HP:0001994)1.99258970
63Volvulus (HP:0002580)1.98943610
64Alveolar cell carcinoma (HP:0006519)1.98142995
65Hypothermia (HP:0002045)1.97531344
66Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97380824
67Obstructive lung disease (HP:0006536)1.94272770
68Chronic obstructive pulmonary disease (HP:0006510)1.94272770
69Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92427890
70Myositis (HP:0100614)1.91109331
71Neutropenia (HP:0001875)1.90935758
72Absent/shortened dynein arms (HP:0200106)1.87640853
73Dynein arm defect of respiratory motile cilia (HP:0012255)1.87640853
74Myelodysplasia (HP:0002863)1.87611638
75Retrobulbar optic neuritis (HP:0100654)1.87166020
76Optic neuritis (HP:0100653)1.87166020
77Chronic sinusitis (HP:0011109)1.86858105
78Carpal bone hypoplasia (HP:0001498)1.86801646
79Progressive macrocephaly (HP:0004481)1.86746832
80Truncal obesity (HP:0001956)1.85988936
81Mitochondrial inheritance (HP:0001427)1.85184063
82Recurrent bacterial skin infections (HP:0005406)1.84825250
83Aplasia/Hypoplasia of the thymus (HP:0010515)1.84476798
84Pancreatic cysts (HP:0001737)1.83742772
8511 pairs of ribs (HP:0000878)1.81400472
86Recurrent fungal infections (HP:0002841)1.80449910
87Autoimmune thrombocytopenia (HP:0001973)1.79832735
88Pendular nystagmus (HP:0012043)1.77599357
89Increased CSF lactate (HP:0002490)1.75560976
90Cleft eyelid (HP:0000625)1.74472502
91Increased muscle lipid content (HP:0009058)1.73731667
92Chronic diarrhea (HP:0002028)1.73616119
93Hypergammaglobulinemia (HP:0010702)1.73050701
94Neoplasm of the tracheobronchial system (HP:0100552)1.71850365
95Pallor (HP:0000980)1.71370086
96Acute encephalopathy (HP:0006846)1.70417568
97Muscle fiber atrophy (HP:0100295)1.70208147
98Abnormality of glycolipid metabolism (HP:0010969)1.69231881
99Abnormality of liposaccharide metabolism (HP:0010968)1.69231881
100Abnormality of glycosphingolipid metabolism (HP:0004343)1.69231881

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.85132216
2TXK3.13922333
3MAP4K13.09281120
4IKBKB2.91069721
5PNCK2.58653170
6BMPR22.44530900
7CSF1R2.44274547
8IKBKE2.37668113
9STK162.23241557
10TLK12.21583876
11MAP3K142.13706575
12BTK1.88822860
13IRAK31.83040978
14TBK11.82963259
15NME21.77437275
16TEC1.74496190
17GRK71.69293693
18SYK1.58990402
19GRK61.58742027
20RIPK41.57716592
21PLK41.57240795
22ADRBK21.53334024
23ITK1.49967293
24RPS6KA41.45775858
25BMX1.44670519
26IRAK41.44010203
27NUAK11.43396832
28CHUK1.36847646
29MAP3K111.36019446
30CDC71.31226441
31PTK2B1.30448384
32BCKDK1.28296626
33KDR1.26997160
34ZAK1.24600885
35MAPKAPK31.16943480
36PRPF4B1.15081237
37TAOK21.12096797
38GRK51.07873113
39JAK31.07683170
40MAP2K31.06047881
41CDK41.05414312
42DAPK11.02074934
43BLK1.00688813
44TYK20.97810216
45MAP2K20.97447750
46ATR0.95718930
47PIM10.94288877
48IRAK20.94231011
49VRK20.93314849
50MAP3K130.88949654
51PRKCQ0.88482392
52MAPK110.87792752
53TSSK60.87633778
54TNK20.87243379
55HCK0.86924050
56NEK20.85532492
57LCK0.84358083
58MAPKAPK50.83328406
59CDK60.83236577
60RPS6KB20.81409888
61RPS6KA50.79270504
62FES0.78922986
63SMG10.76745223
64LYN0.75483383
65FGR0.75117342
66VRK10.75115752
67MET0.72477945
68INSRR0.72239106
69MAP3K70.70926357
70AURKA0.70167352
71BRD40.66315022
72HIPK20.66199962
73PDK10.65548599
74BUB10.65468331
75CDK90.62878986
76CHEK20.62714040
77EIF2AK30.61067922
78CSK0.60366063
79MAP2K60.60062299
80MST40.53927400
81TRIB30.53465922
82ICK0.53332715
83MATK0.52210920
84CDK70.51974596
85CHEK10.50187227
86ZAP700.48222176
87TGFBR20.46874489
88JAK20.46778919
89PRKG20.45980107
90EIF2AK20.45844035
91SIK10.43915259
92PRKCI0.42574678
93RPS6KA60.40378727
94IGF1R0.35372885
95MAPK30.35262163
96DAPK20.33656633
97MAP3K100.33642593
98BRAF0.33494296
99CDK30.31880100
100MAPK70.31775873

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.93175899
2Allograft rejection_Homo sapiens_hsa053303.22820682
3Autoimmune thyroid disease_Homo sapiens_hsa053203.11542830
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.84014463
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.81887412
6Ribosome_Homo sapiens_hsa030102.81333142
7Asthma_Homo sapiens_hsa053102.73933657
8Graft-versus-host disease_Homo sapiens_hsa053322.72047025
9RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.57297278
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.55991792
11RNA polymerase_Homo sapiens_hsa030202.35419015
12T cell receptor signaling pathway_Homo sapiens_hsa046602.15882461
13Antigen processing and presentation_Homo sapiens_hsa046122.08159247
14Type I diabetes mellitus_Homo sapiens_hsa049401.76904784
15Measles_Homo sapiens_hsa051621.74325790
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.73153632
17DNA replication_Homo sapiens_hsa030301.68285082
18TNF signaling pathway_Homo sapiens_hsa046681.66910024
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60187839
20Rheumatoid arthritis_Homo sapiens_hsa053231.57083218
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50940756
22Herpes simplex infection_Homo sapiens_hsa051681.50109921
23Hematopoietic cell lineage_Homo sapiens_hsa046401.48154500
24Leishmaniasis_Homo sapiens_hsa051401.47439983
25Viral myocarditis_Homo sapiens_hsa054161.44866062
26Homologous recombination_Homo sapiens_hsa034401.43270729
27Spliceosome_Homo sapiens_hsa030401.43251083
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42399455
29Systemic lupus erythematosus_Homo sapiens_hsa053221.41657106
30B cell receptor signaling pathway_Homo sapiens_hsa046621.41245189
31Epstein-Barr virus infection_Homo sapiens_hsa051691.37519935
32Pyrimidine metabolism_Homo sapiens_hsa002401.32354378
33RNA transport_Homo sapiens_hsa030131.29594785
34Influenza A_Homo sapiens_hsa051641.28016479
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27128320
36Chemokine signaling pathway_Homo sapiens_hsa040621.22932820
37Osteoclast differentiation_Homo sapiens_hsa043801.18998518
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17690514
39RNA degradation_Homo sapiens_hsa030181.15748352
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07988056
41Proteasome_Homo sapiens_hsa030501.05911754
42Oxidative phosphorylation_Homo sapiens_hsa001901.04269909
43Acute myeloid leukemia_Homo sapiens_hsa052211.02155092
44Parkinsons disease_Homo sapiens_hsa050121.01414195
45Fanconi anemia pathway_Homo sapiens_hsa034601.00919842
46Toxoplasmosis_Homo sapiens_hsa051450.99062256
47Sulfur relay system_Homo sapiens_hsa041220.95592334
48Shigellosis_Homo sapiens_hsa051310.95024117
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.93054833
50HTLV-I infection_Homo sapiens_hsa051660.91386618
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89712831
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89479182
53Hepatitis B_Homo sapiens_hsa051610.86977632
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85098253
55Nucleotide excision repair_Homo sapiens_hsa034200.82976074
56Base excision repair_Homo sapiens_hsa034100.79129337
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78909171
58Viral carcinogenesis_Homo sapiens_hsa052030.77486470
59Hepatitis C_Homo sapiens_hsa051600.75627389
60MAPK signaling pathway_Homo sapiens_hsa040100.73478660
61Huntingtons disease_Homo sapiens_hsa050160.71822806
62Legionellosis_Homo sapiens_hsa051340.67996473
63African trypanosomiasis_Homo sapiens_hsa051430.66075965
64mRNA surveillance pathway_Homo sapiens_hsa030150.65995508
65Tuberculosis_Homo sapiens_hsa051520.64727151
66Malaria_Homo sapiens_hsa051440.63970604
67Chronic myeloid leukemia_Homo sapiens_hsa052200.63869883
68Apoptosis_Homo sapiens_hsa042100.58415102
69Purine metabolism_Homo sapiens_hsa002300.57640141
70Non-small cell lung cancer_Homo sapiens_hsa052230.55889756
71Protein export_Homo sapiens_hsa030600.53438974
72Staphylococcus aureus infection_Homo sapiens_hsa051500.53329952
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52806965
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.51000228
75Alzheimers disease_Homo sapiens_hsa050100.49228317
76Bladder cancer_Homo sapiens_hsa052190.48726043
77Mismatch repair_Homo sapiens_hsa034300.48233010
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45907606
79p53 signaling pathway_Homo sapiens_hsa041150.45321073
80One carbon pool by folate_Homo sapiens_hsa006700.43679022
81Prolactin signaling pathway_Homo sapiens_hsa049170.43168633
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42687975
83Melanoma_Homo sapiens_hsa052180.42282291
84Folate biosynthesis_Homo sapiens_hsa007900.42000183
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41384080
86Small cell lung cancer_Homo sapiens_hsa052220.41299526
87Platelet activation_Homo sapiens_hsa046110.40484673
88Cell cycle_Homo sapiens_hsa041100.36638779
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33442220
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32984574
91Alcoholism_Homo sapiens_hsa050340.30271444
92Prostate cancer_Homo sapiens_hsa052150.29168460
93Dorso-ventral axis formation_Homo sapiens_hsa043200.28426727
94VEGF signaling pathway_Homo sapiens_hsa043700.27802335
95Basal transcription factors_Homo sapiens_hsa030220.24907883
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.22304333
97MicroRNAs in cancer_Homo sapiens_hsa052060.21849903
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20717478
99Selenocompound metabolism_Homo sapiens_hsa004500.19081486
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18124093

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