C17ORF74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.33877120
2DNA packaging (GO:0006323)9.22295591
3spermatid development (GO:0007286)9.05939534
4spermatid nucleus differentiation (GO:0007289)8.66573340
5single strand break repair (GO:0000012)8.61336314
6microtubule depolymerization (GO:0007019)8.21621964
7plasma membrane fusion (GO:0045026)8.03289557
8sperm-egg recognition (GO:0035036)7.56092515
9negative regulation of inclusion body assembly (GO:0090084)7.55774333
10phosphatidylethanolamine biosynthetic process (GO:0006646)7.47867331
11protein polyglutamylation (GO:0018095)7.44840615
12multicellular organism reproduction (GO:0032504)7.43291173
13response to pheromone (GO:0019236)7.34382270
14sexual reproduction (GO:0019953)7.26588120
15rRNA methylation (GO:0031167)7.13699570
16reproduction (GO:0000003)7.12992063
17phosphatidylethanolamine metabolic process (GO:0046337)6.90516408
18binding of sperm to zona pellucida (GO:0007339)6.85985458
19microtubule severing (GO:0051013)6.80985581
20calcium ion-dependent exocytosis (GO:0017156)6.61377742
21microtubule polymerization or depolymerization (GO:0031109)6.44627127
22protein targeting to Golgi (GO:0000042)6.32148334
23axonemal dynein complex assembly (GO:0070286)6.23154126
24cell-cell recognition (GO:0009988)6.22289435
25spermatogenesis (GO:0007283)6.12433888
26male gamete generation (GO:0048232)6.10333206
27establishment of protein localization to Golgi (GO:0072600)6.05773471
28rRNA modification (GO:0000154)6.01732121
29cellular ketone body metabolic process (GO:0046950)5.98334816
30regulation of cilium movement (GO:0003352)5.93947232
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.90563280
32gamete generation (GO:0007276)5.59390585
33regulation of inclusion body assembly (GO:0090083)5.42703636
34ketone body metabolic process (GO:1902224)5.28257038
35single fertilization (GO:0007338)5.04376846
36RNA destabilization (GO:0050779)5.03581733
37germ cell development (GO:0007281)4.99179290
38cilium or flagellum-dependent cell motility (GO:0001539)4.94230469
39centriole replication (GO:0007099)4.90568704
40motile cilium assembly (GO:0044458)4.84206719
41positive regulation of Rab GTPase activity (GO:0032851)4.79945728
42regulation of Rab GTPase activity (GO:0032313)4.79945728
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.69993914
44cell wall macromolecule catabolic process (GO:0016998)4.69304744
45regulation of transcription involved in cell fate commitment (GO:0060850)4.62743796
46multicellular organismal reproductive process (GO:0048609)4.51618114
47protein localization to Golgi apparatus (GO:0034067)4.51300539
48nucleus organization (GO:0006997)4.48913916
49centriole assembly (GO:0098534)4.48818766
50chromatin silencing (GO:0006342)4.47697647
51cell wall macromolecule metabolic process (GO:0044036)4.41861567
52regulation of microtubule-based movement (GO:0060632)4.33727044
53epithelial cilium movement (GO:0003351)4.24841061
54organic cation transport (GO:0015695)4.19639999
55fertilization (GO:0009566)4.14560095
56polyamine biosynthetic process (GO:0006596)4.07093027
57response to acidic pH (GO:0010447)3.99426599
58regulation of centriole replication (GO:0046599)3.87539934
59protein-DNA complex disassembly (GO:0032986)3.86788413
60nucleosome disassembly (GO:0006337)3.86788413
61peptidyl-threonine dephosphorylation (GO:0035970)3.79096166
62membrane protein intracellular domain proteolysis (GO:0031293)3.68577198
63cilium movement (GO:0003341)3.68518274
64multicellular organismal movement (GO:0050879)3.65811611
65musculoskeletal movement (GO:0050881)3.65811611
66cellular response to pH (GO:0071467)3.58394117
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52500354
68cerebral cortex neuron differentiation (GO:0021895)3.43776780
69homeostasis of number of cells within a tissue (GO:0048873)3.42445542
70coenzyme catabolic process (GO:0009109)3.34312487
71seminiferous tubule development (GO:0072520)3.32129298
72regulation of interleukin-13 production (GO:0032656)3.25826069
73multicellular organismal development (GO:0007275)3.25036318
74negative regulation of Rho protein signal transduction (GO:0035024)3.17014732
75glycerol ether metabolic process (GO:0006662)3.14717081
76regulation of T-helper 2 cell differentiation (GO:0045628)3.13081020
77mitochondrial fission (GO:0000266)3.10295123
78cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08508064
79protein depolymerization (GO:0051261)3.06946607
80negative regulation of gene expression, epigenetic (GO:0045814)3.04554606
81cell recognition (GO:0008037)2.99397829
82histone H3-K9 demethylation (GO:0033169)2.97644723
83DNA conformation change (GO:0071103)2.96490191
84cranial nerve morphogenesis (GO:0021602)2.94400936
85genitalia morphogenesis (GO:0035112)2.93770362
86ether metabolic process (GO:0018904)2.89897119
87microtubule nucleation (GO:0007020)2.85736120
88regulation of phosphoprotein phosphatase activity (GO:0043666)2.83161614
89chaperone-mediated protein complex assembly (GO:0051131)2.82724369
90positive regulation of guanylate cyclase activity (GO:0031284)2.81689897
91regulation of female gonad development (GO:2000194)2.79966045
92mitotic G1 DNA damage checkpoint (GO:0031571)2.78949777
93histone exchange (GO:0043486)2.74439021
94RNA localization (GO:0006403)2.73644860
95negative regulation of histone methylation (GO:0031061)2.71398181
96regulation of guanylate cyclase activity (GO:0031282)2.67356492
97sperm motility (GO:0030317)12.5590960
98acrosome reaction (GO:0007340)12.4080503
99fusion of sperm to egg plasma membrane (GO:0007342)10.5890265
100sperm capacitation (GO:0048240)10.2174118

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.95160780
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.56406365
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.46678278
4EZH2_22144423_ChIP-Seq_EOC_Human2.57544315
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.40090478
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40090478
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.34717891
8CBP_20019798_ChIP-Seq_JUKART_Human2.09676906
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.09676906
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08619441
11CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97719211
12DROSHA_22980978_ChIP-Seq_HELA_Human1.97251673
13CTCF_27219007_Chip-Seq_Bcells_Human1.95956510
14* ELF1_20517297_ChIP-Seq_JURKAT_Human1.93357160
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93208172
16RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.89599518
17RAC3_21632823_ChIP-Seq_H3396_Human1.85948396
18ERA_21632823_ChIP-Seq_H3396_Human1.84668332
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81924001
20* NANOG_20526341_ChIP-Seq_ESCs_Human1.73724226
21* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.72832426
22* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.72031743
23FUS_26573619_Chip-Seq_HEK293_Human1.71116599
24EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.70664096
25WDR5_24793694_ChIP-Seq_LNCAP_Human1.69086453
26* BCL6_27268052_Chip-Seq_Bcells_Human1.66212025
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66026494
28E2F1_20622854_ChIP-Seq_HELA_Human1.63055890
29PHF8_20622854_ChIP-Seq_HELA_Human1.60862196
30LXR_22292898_ChIP-Seq_THP-1_Human1.56615874
31* SMC4_20622854_ChIP-Seq_HELA_Human1.56133213
32* BCOR_27268052_Chip-Seq_Bcells_Human1.55924827
33CTCF_20526341_ChIP-Seq_ESCs_Human1.50795392
34* TAF2_19829295_ChIP-Seq_ESCs_Human1.50763804
35* YY1_22570637_ChIP-Seq_MALME-3M_Human1.50342418
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49970411
37* P68_20966046_ChIP-Seq_HELA_Human1.49655949
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46380103
39MYC_19829295_ChIP-Seq_ESCs_Human1.46368707
40* TP63_22573176_ChIP-Seq_HFKS_Human1.45597132
41ERG_20517297_ChIP-Seq_VCAP_Human1.45153749
42* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44694685
43EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.44490316
44AR_25329375_ChIP-Seq_VCAP_Human1.44157640
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43831822
46SMAD4_21741376_ChIP-Seq_EPCs_Human1.43705487
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.42994404
48BP1_19119308_ChIP-ChIP_Hs578T_Human1.42892071
49* OCT4_20526341_ChIP-Seq_ESCs_Human1.40075049
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39496686
51P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.37750237
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37565520
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37253971
54ER_23166858_ChIP-Seq_MCF-7_Human1.37163649
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35941431
56* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.35756945
57RBPJ_21746931_ChIP-Seq_IB4_Human1.35669233
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.34887962
59RUNX1_26923725_Chip-Seq_HPCs_Mouse1.34412589
60CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34037429
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.33151093
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32629938
63* P300_27268052_Chip-Seq_Bcells_Human1.32484865
64CBX2_22325352_ChIP-Seq_293T-Rex_Human1.31433536
65SOX2_22085726_ChIP-Seq_NPCs_Mouse1.31188703
66SMAD3_21741376_ChIP-Seq_ESCs_Human1.30589516
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.29499473
68ETV1_20927104_ChIP-Seq_GIST48_Human1.26563405
69CEBPB_22108803_ChIP-Seq_LS180_Human1.21283774
70TP53_18474530_ChIP-ChIP_U2OS_Human1.21108011
71* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17906368
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.16686757
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.16049840
74P53_21459846_ChIP-Seq_SAOS-2_Human1.15837937
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.14427054
76NFYB_21822215_ChIP-Seq_K562_Human1.14087686
77TP63_19390658_ChIP-ChIP_HaCaT_Human1.13385395
78SA1_27219007_Chip-Seq_Bcells_Human1.13105598
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.12551397
80RUNX_20019798_ChIP-Seq_JUKART_Human1.11145120
81TBL1_22424771_ChIP-Seq_293T_Human1.10432587
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08688912
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08476829
84P300_19829295_ChIP-Seq_ESCs_Human1.08371859
85GATA6_21074721_ChIP-Seq_CACO-2_Human1.06921493
86PHF8_20622853_ChIP-Seq_HELA_Human1.06298336
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.05207190
88* SMRT_27268052_Chip-Seq_Bcells_Human1.04224576
89CSB_26484114_Chip-Seq_FIBROBLAST_Human1.03485190
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02744672
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.02226673
92OCT4_19829295_ChIP-Seq_ESCs_Human1.00908957
93NFYA_21822215_ChIP-Seq_K562_Human1.00608328
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00589144
95FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00294714
96SMAD4_21799915_ChIP-Seq_A2780_Human0.99727648
97TAF15_26573619_Chip-Seq_HEK293_Human0.99450466
98SOX2_19829295_ChIP-Seq_ESCs_Human0.98922786
99NANOG_19829295_ChIP-Seq_ESCs_Human0.98922786
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97859333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.39315452
2MP0003878_abnormal_ear_physiology4.88941706
3MP0005377_hearing/vestibular/ear_phenot4.88941706
4MP0003698_abnormal_male_reproductive4.76622958
5MP0001929_abnormal_gametogenesis4.18810260
6MP0001348_abnormal_lacrimal_gland3.01660325
7MP0002161_abnormal_fertility/fecundity2.72238635
8MP0000678_abnormal_parathyroid_gland2.31052351
9MP0003718_maternal_effect2.13229484
10MP0005410_abnormal_fertilization12.9716547
11MP0002210_abnormal_sex_determination1.97381617
12MP0003646_muscle_fatigue1.96002475
13MP0003011_delayed_dark_adaptation1.84177607
14MP0002132_abnormal_respiratory_system1.70678156
15MP0002822_catalepsy1.61429274
16MP0001145_abnormal_male_reproductive1.59694173
17MP0002234_abnormal_pharynx_morphology1.53327206
18MP0005423_abnormal_somatic_nervous1.53059907
19MP0000653_abnormal_sex_gland1.51801112
20MP0001485_abnormal_pinna_reflex1.46311563
21MP0002249_abnormal_larynx_morphology1.45804416
22MP0009053_abnormal_anal_canal1.33410537
23MP0005379_endocrine/exocrine_gland_phen1.33376181
24MP0005310_abnormal_salivary_gland1.28385134
25MP0002282_abnormal_trachea_morphology1.27707172
26MP0004859_abnormal_synaptic_plasticity1.26941176
27MP0000534_abnormal_ureter_morphology1.25225699
28MP0001486_abnormal_startle_reflex1.23030555
29MP0002138_abnormal_hepatobiliary_system1.19287038
30MP0001765_abnormal_ion_homeostasis1.13058759
31MP0002735_abnormal_chemical_nociception1.11655380
32MP0003879_abnormal_hair_cell1.09258422
33MP0005451_abnormal_body_composition1.07732661
34MP0001963_abnormal_hearing_physiology1.02282437
35MP0009115_abnormal_fat_cell1.01269470
36MP0002127_abnormal_cardiovascular_syste0.98915281
37MP0004742_abnormal_vestibular_system0.98286496
38MP0001968_abnormal_touch/_nociception0.97504830
39MP0005666_abnormal_adipose_tissue0.96867900
40MP0005395_other_phenotype0.95898656
41MP0008569_lethality_at_weaning0.92450763
42MP0000026_abnormal_inner_ear0.89424853
43MP0000955_abnormal_spinal_cord0.86669262
44MP0008877_abnormal_DNA_methylation0.86375719
45MP0004510_myositis0.85906568
46MP0002229_neurodegeneration0.85236898
47MP0005248_abnormal_Harderian_gland0.84315968
48MP0001905_abnormal_dopamine_level0.79919127
49MP0005083_abnormal_biliary_tract0.78876370
50MP0005551_abnormal_eye_electrophysiolog0.76270429
51MP0002067_abnormal_sensory_capabilities0.73210260
52MP0005375_adipose_tissue_phenotype0.72522847
53MP0002557_abnormal_social/conspecific_i0.71911766
54MP0000681_abnormal_thyroid_gland0.70565266
55MP0000049_abnormal_middle_ear0.69898664
56MP0005253_abnormal_eye_physiology0.61928458
57MP0001879_abnormal_lymphatic_vessel0.61049270
58MP0004085_abnormal_heartbeat0.60314454
59MP0005636_abnormal_mineral_homeostasis0.57760371
60MP0003077_abnormal_cell_cycle0.55956564
61MP0001666_abnormal_nutrient_absorption0.55053079
62MP0002733_abnormal_thermal_nociception0.52956579
63MP0003699_abnormal_female_reproductive0.52411738
64MP0000516_abnormal_urinary_system0.50107017
65MP0005367_renal/urinary_system_phenotyp0.50107017
66MP0002272_abnormal_nervous_system0.49785185
67MP0002572_abnormal_emotion/affect_behav0.49775761
68MP0001440_abnormal_grooming_behavior0.48589239
69MP0001270_distended_abdomen0.48490704
70MP0009745_abnormal_behavioral_response0.48206130
71MP0000003_abnormal_adipose_tissue0.47621198
72MP0009697_abnormal_copulation0.47096682
73MP0004484_altered_response_of0.46385436
74MP0000613_abnormal_salivary_gland0.45508060
75MP0002734_abnormal_mechanical_nocicepti0.45141756
76MP0003091_abnormal_cell_migration0.44213333
77MP0008961_abnormal_basal_metabolism0.43079090
78MP0005535_abnormal_body_temperature0.40216993
79MP0010329_abnormal_lipoprotein_level0.39361270
80MP0008995_early_reproductive_senescence0.39293723
81MP0003631_nervous_system_phenotype0.39193376
82MP0005167_abnormal_blood-brain_barrier0.38377829
83MP0005647_abnormal_sex_gland0.38266995
84MP0002928_abnormal_bile_duct0.38150928
85MP0000470_abnormal_stomach_morphology0.37975679
86MP0003632_abnormal_nervous_system0.37723271
87MP0005084_abnormal_gallbladder_morpholo0.37404099
88MP0003137_abnormal_impulse_conducting0.37375419
89MP0003119_abnormal_digestive_system0.37166513
90MP0001970_abnormal_pain_threshold0.37027382
91MP0000249_abnormal_blood_vessel0.36653220
92MP0004233_abnormal_muscle_weight0.35568448
93MP0001873_stomach_inflammation0.34928932
94MP0004036_abnormal_muscle_relaxation0.34676570
95MP0006292_abnormal_olfactory_placode0.33918702
96MP0005408_hypopigmentation0.33265860
97MP0005391_vision/eye_phenotype0.32772260
98MP0003959_abnormal_lean_body0.32337605
99MP0003936_abnormal_reproductive_system0.32306781
100MP0001501_abnormal_sleep_pattern0.32206356

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.50450332
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.92365835
3Absent/shortened dynein arms (HP:0200106)5.92365835
4Tubulointerstitial nephritis (HP:0001970)5.65347791
5Bony spicule pigmentary retinopathy (HP:0007737)5.20558909
6Hyperkalemia (HP:0002153)5.12385761
7Chronic hepatic failure (HP:0100626)5.07973511
8Attenuation of retinal blood vessels (HP:0007843)5.04752014
9Asymmetric septal hypertrophy (HP:0001670)4.76568647
10Resting tremor (HP:0002322)4.65602168
11Abnormal ciliary motility (HP:0012262)4.55657321
12Abnormal respiratory motile cilium physiology (HP:0012261)4.52623060
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.42850029
14Infertility (HP:0000789)4.41626445
15Abnormal respiratory epithelium morphology (HP:0012253)4.38774309
16Abnormal respiratory motile cilium morphology (HP:0005938)4.38774309
17Bell-shaped thorax (HP:0001591)4.35279122
18Abnormality of macular pigmentation (HP:0008002)4.29736342
19Nasal polyposis (HP:0100582)4.24363588
20Male infertility (HP:0003251)4.21790519
21Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.09415440
22Abnormal rod and cone electroretinograms (HP:0008323)4.09368506
23Potter facies (HP:0002009)4.08201988
24Facial shape deformation (HP:0011334)4.08201988
25Cone-rod dystrophy (HP:0000548)3.92734329
26Hypoplasia of the thymus (HP:0000778)3.53354630
27Hypoalphalipoproteinemia (HP:0003233)3.52988652
28Abnormality of the nasal mucosa (HP:0000433)3.45304434
29Hypoplastic ischia (HP:0003175)3.43825586
30Progressive sensorineural hearing impairment (HP:0000408)3.40446408
31Impulsivity (HP:0100710)3.38668485
32Abnormal spermatogenesis (HP:0008669)3.35321311
33Azoospermia (HP:0000027)3.32786072
34Aplasia/Hypoplasia of the earlobes (HP:0009906)3.25319059
35Enlarged epiphyses (HP:0010580)3.21275614
36Postural instability (HP:0002172)3.13654376
37Abnormality of the ischium (HP:0003174)3.08262696
38Menstrual irregularities (HP:0000858)3.04123791
39Renovascular hypertension (HP:0100817)2.98336498
40Truncal obesity (HP:0001956)2.94573507
41Unilateral renal agenesis (HP:0000122)2.88737175
42Rhinitis (HP:0012384)2.83426217
43Insulin-resistant diabetes mellitus (HP:0000831)2.80021676
44Abnormality of potassium homeostasis (HP:0011042)2.78008439
45Generalized aminoaciduria (HP:0002909)2.76208169
46Abnormal urine output (HP:0012590)2.73765547
47Congenital malformation of the right heart (HP:0011723)2.71989860
48Double outlet right ventricle (HP:0001719)2.71989860
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.71331260
50Renal dysplasia (HP:0000110)2.70228574
51Abnormality of the aortic arch (HP:0012303)2.64655888
52Nephronophthisis (HP:0000090)2.63062935
53Portal hypertension (HP:0001409)2.58600349
54Tubulointerstitial abnormality (HP:0001969)2.57542595
55Progressive cerebellar ataxia (HP:0002073)2.47929153
56Amelogenesis imperfecta (HP:0000705)2.46500083
57Abnormality of renal excretion (HP:0011036)2.37112428
58Abnormality of the hepatic vasculature (HP:0006707)2.36446914
59Stage 5 chronic kidney disease (HP:0003774)2.35929600
60Abnormality of the costochondral junction (HP:0000919)2.34468564
61Abnormality of dental color (HP:0011073)2.30079141
62Myokymia (HP:0002411)2.23509449
63Abnormality of the renal medulla (HP:0100957)2.22990847
64Abnormal drinking behavior (HP:0030082)2.22118427
65Polydipsia (HP:0001959)2.22118427
66Increased purine levels (HP:0004368)2.21681181
67Hyperuricemia (HP:0002149)2.21681181
68Abnormality of the parathyroid morphology (HP:0011766)2.19428334
69Flattened epiphyses (HP:0003071)2.18532837
70Progressive hearing impairment (HP:0001730)2.14616594
71Osteomalacia (HP:0002749)2.10256015
72Recurrent pneumonia (HP:0006532)2.09408881
73Polyuria (HP:0000103)2.09173756
74Epiphyseal dysplasia (HP:0002656)2.08358335
75Chronic bronchitis (HP:0004469)2.08262837
76Bronchiectasis (HP:0002110)2.05332137
77Widely patent fontanelles and sutures (HP:0004492)2.03987890
78Peripheral hypomyelination (HP:0007182)1.96551820
79Ventricular tachycardia (HP:0004756)1.95922329
80Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94628130
81Hyponatremia (HP:0002902)1.92424005
82Absent epiphyses (HP:0010577)1.91714693
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91714693
84Abnormality of the epiphysis of the femoral head (HP:0010574)1.90628814
85Tetany (HP:0001281)1.90054776
86Optic nerve hypoplasia (HP:0000609)1.89819729
87Subcapsular cataract (HP:0000523)1.87312864
88Abnormal ventriculo-arterial connection (HP:0011563)1.85978889
89Transposition of the great arteries (HP:0001669)1.85978889
90Abnormal connection of the cardiac segments (HP:0011545)1.85978889
91Hypophosphatemic rickets (HP:0004912)1.85283601
92Abnormality of chloride homeostasis (HP:0011422)1.79439948
93Flat capital femoral epiphysis (HP:0003370)1.78853435
94Upper limb muscle weakness (HP:0003484)1.78569386
95Abnormality of femoral epiphyses (HP:0006499)1.77659517
96Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77659517
97Neoplasm of the heart (HP:0100544)1.74687057
98Renal Fanconi syndrome (HP:0001994)1.74062687
99Insulin resistance (HP:0000855)1.72584038
100Abnormality of the pubic bones (HP:0003172)1.72081017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.53132364
2TESK16.39191562
3DDR24.68792293
4STK384.44410131
5PNCK3.49726025
6MAP4K23.28797066
7PRKD33.12250244
8STK38L3.04642453
9BRD42.79636863
10PLK22.69045726
11INSRR2.66284002
12CAMK1G2.58264680
13MAPK152.51831396
14MST1R2.12639016
15DYRK1B1.75219231
16PDPK11.71230919
17NEK61.58094924
18PDK11.54684377
19WNK11.39677614
20CDK121.35766505
21PIK3CG1.33405370
22CDK71.18969304
23AKT31.14532016
24MAP3K91.12217635
25KSR21.11163829
26SIK21.03383408
27PTK2B0.96747802
28BRAF0.88036795
29RIPK40.85259098
30CAMK1D0.83978695
31WNK40.82358719
32MAP3K110.74328905
33STK390.72875827
34RPS6KA20.72586182
35UHMK10.71155017
36RPS6KA10.71099460
37MAP2K20.69472305
38MAP3K20.68575575
39PRKG10.66437808
40TYRO30.66251175
41LATS20.64751716
42PRKG20.64344239
43ROCK10.61415209
44MAP3K80.61393218
45CAMK10.58008042
46SGK4940.56320345
47SGK2230.56320345
48GSK3B0.51200303
49CDK20.50944317
50CDK30.48833948
51LATS10.48610531
52PRKAA20.47526251
53MTOR0.44775420
54CDK40.43870493
55MAP3K10.43447071
56MAPK80.43277666
57CDK10.43154859
58BMPR1B0.42599354
59MAPK10.40894453
60TESK20.40679945
61RPS6KL10.38109701
62RPS6KC10.38109701
63MET0.37772555
64RPS6KA60.35429570
65PRKCZ0.35334982
66SGK10.35202597
67ARAF0.34509463
68MUSK0.32882355
69CHEK10.32370748
70CAMK40.31177292
71PRKCG0.29447218
72NTRK30.27168758
73MAPK140.26679251
74MINK10.26291669
75PRKCB0.25816678
76MAPK100.25439779
77PINK10.23681469
78MARK10.23361942
79MARK20.21985764
80NEK20.19554268
81MAPK110.18100782
82MAP3K40.18015280
83OXSR10.17189976
84AKT10.16166690
85JAK30.15636233
86TNIK0.15271994
87BRSK10.15064171
88TIE10.12798585
89FER0.10946397
90PRKAA10.09901861
91SGK20.09439492
92PRKACB0.09049928
93PKN10.08821080
94PRKACA0.08061840
95ACVR1B0.07344151
96MAPK90.07186705
97PRKCA0.05836813
98DYRK20.05411497
99RPS6KA30.05061472
100RIPK10.04427543

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.11218567
2Fatty acid biosynthesis_Homo sapiens_hsa000617.55604594
3Olfactory transduction_Homo sapiens_hsa047403.02777632
4Butanoate metabolism_Homo sapiens_hsa006502.64723754
5Glycerophospholipid metabolism_Homo sapiens_hsa005642.19206110
6Fatty acid degradation_Homo sapiens_hsa000712.11604151
7Fatty acid metabolism_Homo sapiens_hsa012121.96597463
8Dorso-ventral axis formation_Homo sapiens_hsa043201.86544369
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83963196
10Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.74982065
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.73362110
12Type II diabetes mellitus_Homo sapiens_hsa049301.51012739
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.49660907
14Adipocytokine signaling pathway_Homo sapiens_hsa049201.49588963
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.49362000
16RNA transport_Homo sapiens_hsa030131.36405099
17Taste transduction_Homo sapiens_hsa047421.35677879
18Phenylalanine metabolism_Homo sapiens_hsa003601.30278984
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.29640285
20Type I diabetes mellitus_Homo sapiens_hsa049401.21302638
21PPAR signaling pathway_Homo sapiens_hsa033201.20905407
22Antigen processing and presentation_Homo sapiens_hsa046121.13308182
23Endocytosis_Homo sapiens_hsa041441.06378059
24Allograft rejection_Homo sapiens_hsa053301.05672473
25Phototransduction_Homo sapiens_hsa047441.04877190
26Autoimmune thyroid disease_Homo sapiens_hsa053201.03708036
27Arginine and proline metabolism_Homo sapiens_hsa003301.00357255
28Selenocompound metabolism_Homo sapiens_hsa004500.99823670
29Morphine addiction_Homo sapiens_hsa050320.95822171
30Graft-versus-host disease_Homo sapiens_hsa053320.93795792
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92646659
32Hedgehog signaling pathway_Homo sapiens_hsa043400.91617019
33Salivary secretion_Homo sapiens_hsa049700.88690589
34Protein digestion and absorption_Homo sapiens_hsa049740.88537635
35Inositol phosphate metabolism_Homo sapiens_hsa005620.87350860
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85304809
37Arginine biosynthesis_Homo sapiens_hsa002200.83476042
38Synaptic vesicle cycle_Homo sapiens_hsa047210.80810887
39Calcium signaling pathway_Homo sapiens_hsa040200.80454447
40Circadian entrainment_Homo sapiens_hsa047130.79288484
41Viral myocarditis_Homo sapiens_hsa054160.77665115
42Renin-angiotensin system_Homo sapiens_hsa046140.77362124
43Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76016504
44cAMP signaling pathway_Homo sapiens_hsa040240.75853232
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73635137
46ABC transporters_Homo sapiens_hsa020100.73262874
47Estrogen signaling pathway_Homo sapiens_hsa049150.71814257
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69022565
49Oocyte meiosis_Homo sapiens_hsa041140.68142192
50Glycerolipid metabolism_Homo sapiens_hsa005610.66919940
51Fat digestion and absorption_Homo sapiens_hsa049750.65556084
52Nicotine addiction_Homo sapiens_hsa050330.61479281
53Cardiac muscle contraction_Homo sapiens_hsa042600.60764607
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59351272
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59320976
56Influenza A_Homo sapiens_hsa051640.58375468
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57785725
58Tight junction_Homo sapiens_hsa045300.57556027
59Tyrosine metabolism_Homo sapiens_hsa003500.55969196
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55147363
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.51793270
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51426232
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.51091069
64Biosynthesis of amino acids_Homo sapiens_hsa012300.49900992
65Glutamatergic synapse_Homo sapiens_hsa047240.48756019
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47868595
67Gastric acid secretion_Homo sapiens_hsa049710.47780301
68Purine metabolism_Homo sapiens_hsa002300.46154484
69Renin secretion_Homo sapiens_hsa049240.45473107
70MAPK signaling pathway_Homo sapiens_hsa040100.44696598
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.40978323
72Retinol metabolism_Homo sapiens_hsa008300.40325439
73Insulin secretion_Homo sapiens_hsa049110.39955133
74Cholinergic synapse_Homo sapiens_hsa047250.39758635
75VEGF signaling pathway_Homo sapiens_hsa043700.39273214
76Serotonergic synapse_Homo sapiens_hsa047260.38693859
77Bile secretion_Homo sapiens_hsa049760.38562083
78Acute myeloid leukemia_Homo sapiens_hsa052210.36731638
79GABAergic synapse_Homo sapiens_hsa047270.33125653
80Basal transcription factors_Homo sapiens_hsa030220.30987677
81Pancreatic secretion_Homo sapiens_hsa049720.27150968
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26795503
83Nitrogen metabolism_Homo sapiens_hsa009100.25307741
84Oxytocin signaling pathway_Homo sapiens_hsa049210.24026172
85Viral carcinogenesis_Homo sapiens_hsa052030.21969259
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20780712
87Prolactin signaling pathway_Homo sapiens_hsa049170.20259856
88Long-term potentiation_Homo sapiens_hsa047200.19920772
89mRNA surveillance pathway_Homo sapiens_hsa030150.18956330
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18562748
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.16335327
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.16245204
93Alcoholism_Homo sapiens_hsa050340.15295775
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15262018
95Metabolic pathways_Homo sapiens_hsa011000.14876879
96Carbon metabolism_Homo sapiens_hsa012000.14672747
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.13402129
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.13257768
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12757797
100Huntingtons disease_Homo sapiens_hsa050160.12740146

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