C17ORF80

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.21033275
2mitotic sister chromatid cohesion (GO:0007064)4.70940627
3nuclear pore organization (GO:0006999)4.57263235
4mitotic metaphase plate congression (GO:0007080)4.42253964
5protein localization to kinetochore (GO:0034501)4.00948239
6DNA double-strand break processing (GO:0000729)4.00703850
7protein localization to chromosome, centromeric region (GO:0071459)3.85194132
8metaphase plate congression (GO:0051310)3.78403309
9ribosome assembly (GO:0042255)3.72926789
10regulation of centriole replication (GO:0046599)3.69345614
11pore complex assembly (GO:0046931)3.67597909
12sister chromatid segregation (GO:0000819)3.66917387
13spindle checkpoint (GO:0031577)3.61220170
14mitotic nuclear envelope disassembly (GO:0007077)3.59566173
15regulation of mitotic spindle organization (GO:0060236)3.58463110
16mitotic sister chromatid segregation (GO:0000070)3.58036757
17establishment of integrated proviral latency (GO:0075713)3.56419837
18chromatin remodeling at centromere (GO:0031055)3.51729716
19mitotic spindle checkpoint (GO:0071174)3.50339106
20CENP-A containing nucleosome assembly (GO:0034080)3.49519379
21mitotic chromosome condensation (GO:0007076)3.45516103
22negative regulation of mitotic sister chromatid separation (GO:2000816)3.38373629
23negative regulation of sister chromatid segregation (GO:0033046)3.38373629
24negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38373629
25negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.38373629
26negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38373629
27nuclear envelope disassembly (GO:0051081)3.37768681
28membrane disassembly (GO:0030397)3.37768681
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37745635
30negative regulation of chromosome segregation (GO:0051985)3.36640271
31histone exchange (GO:0043486)3.34615856
32regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32582152
33regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32582152
34protein complex localization (GO:0031503)3.30832809
35DNA unwinding involved in DNA replication (GO:0006268)3.25063784
36DNA replication-dependent nucleosome assembly (GO:0006335)3.23893322
37DNA replication-dependent nucleosome organization (GO:0034723)3.23893322
38regulation of mitotic sister chromatid separation (GO:0010965)3.22521313
39regulation of mitotic sister chromatid segregation (GO:0033047)3.22521313
40regulation of sister chromatid segregation (GO:0033045)3.22521313
41regulation of chromosome segregation (GO:0051983)3.22107257
42IMP biosynthetic process (GO:0006188)3.21568375
43mitotic spindle assembly checkpoint (GO:0007094)3.13371332
44establishment of chromosome localization (GO:0051303)3.13159354
45regulation of spindle organization (GO:0090224)3.12530815
46replication fork processing (GO:0031297)3.09468573
47rRNA methylation (GO:0031167)3.09220918
48spindle assembly checkpoint (GO:0071173)3.09099041
49DNA catabolic process, exonucleolytic (GO:0000738)3.08009416
50attachment of spindle microtubules to kinetochore (GO:0008608)3.04242888
51DNA strand elongation involved in DNA replication (GO:0006271)3.03696450
52DNA strand renaturation (GO:0000733)3.01956977
53DNA strand elongation (GO:0022616)2.99701439
54double-strand break repair via nonhomologous end joining (GO:0006303)2.98742939
55non-recombinational repair (GO:0000726)2.98742939
56DNA replication-independent nucleosome assembly (GO:0006336)2.98333007
57DNA replication-independent nucleosome organization (GO:0034724)2.98333007
58IMP metabolic process (GO:0046040)2.97130112
59positive regulation of chromosome segregation (GO:0051984)2.92078841
60regulation of sister chromatid cohesion (GO:0007063)2.91192374
61sister chromatid cohesion (GO:0007062)2.90477957
62rRNA modification (GO:0000154)2.89634977
63positive regulation of mitotic sister chromatid separation (GO:1901970)2.89189709
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89189709
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89189709
66telomere maintenance via semi-conservative replication (GO:0032201)2.88558358
67regulation of mitotic spindle checkpoint (GO:1903504)2.88257151
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.88257151
69cellular protein complex localization (GO:0034629)2.88201833
70mitochondrial RNA metabolic process (GO:0000959)2.85839865
71mitotic recombination (GO:0006312)2.84743296
72protein localization to chromosome (GO:0034502)2.83798720
73ATP-dependent chromatin remodeling (GO:0043044)2.83186402
74negative regulation of DNA-dependent DNA replication (GO:2000104)2.76929117
75establishment of viral latency (GO:0019043)2.73891254
76chromosome segregation (GO:0007059)2.73295701
77histone H2A acetylation (GO:0043968)2.72174948
78maturation of 5.8S rRNA (GO:0000460)2.69626492
79negative regulation of mitosis (GO:0045839)2.68194053
80nuclear envelope organization (GO:0006998)2.68033727
81DNA geometric change (GO:0032392)2.67388493
82regulation of DNA endoreduplication (GO:0032875)2.66615990
83regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64874800
84microtubule depolymerization (GO:0007019)2.64810716
85DNA duplex unwinding (GO:0032508)2.64414004
86DNA replication checkpoint (GO:0000076)2.64327726
87kinetochore organization (GO:0051383)2.64099653
88chromosome condensation (GO:0030261)2.61388466
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60438669
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.60320118
91termination of RNA polymerase II transcription (GO:0006369)2.59469713
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58057196
93regulation of helicase activity (GO:0051095)2.58050043
94DNA damage response, detection of DNA damage (GO:0042769)2.56844906
95regulation of centrosome duplication (GO:0010824)2.56257347
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56136690
97transcription from mitochondrial promoter (GO:0006390)2.55848516
98mitotic G2/M transition checkpoint (GO:0044818)2.55680475
99DNA packaging (GO:0006323)2.54232234
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.53776520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.39990265
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.74475974
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73293927
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.59511430
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.06491061
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.91100315
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.81331513
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.77017499
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.74176470
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.68162809
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57765108
12AR_21909140_ChIP-Seq_LNCAP_Human2.50527484
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44309791
14PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42468391
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41665701
16ELK1_19687146_ChIP-ChIP_HELA_Human2.30068176
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27497201
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20904766
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16874102
20YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14674059
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09331058
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.06092675
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.05788960
24PADI4_21655091_ChIP-ChIP_MCF-7_Human2.02382121
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.98545980
26FUS_26573619_Chip-Seq_HEK293_Human1.92951795
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92875345
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.92482289
29DCP1A_22483619_ChIP-Seq_HELA_Human1.88773534
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85093429
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83644017
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81970318
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80263601
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.80085692
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73138250
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.72413933
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71596847
38EWS_26573619_Chip-Seq_HEK293_Human1.68386998
39VDR_23849224_ChIP-Seq_CD4+_Human1.68103477
40FOXP3_21729870_ChIP-Seq_TREG_Human1.67919757
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64324248
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62780244
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60344901
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54763644
45IGF1R_20145208_ChIP-Seq_DFB_Human1.52784338
46GABP_19822575_ChIP-Seq_HepG2_Human1.52369678
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50895135
48IRF1_19129219_ChIP-ChIP_H3396_Human1.50661784
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50577709
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47416214
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45930348
52TTF2_22483619_ChIP-Seq_HELA_Human1.45563779
53XRN2_22483619_ChIP-Seq_HELA_Human1.39381321
54ZNF274_21170338_ChIP-Seq_K562_Hela1.38991652
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38249191
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38225480
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37084744
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.35936986
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31606051
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.30069319
61NANOG_16153702_ChIP-ChIP_HESCs_Human1.29305685
62POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26550119
63SOX17_20123909_ChIP-Seq_XEN_Mouse1.23560163
64RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.17617191
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13461489
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10295098
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.10000694
68SRF_21415370_ChIP-Seq_HL-1_Mouse1.07904617
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07136055
70TAF15_26573619_Chip-Seq_HEK293_Human1.05988456
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02327209
72NANOG_21062744_ChIP-ChIP_HESCs_Human1.01420539
73P300_19829295_ChIP-Seq_ESCs_Human0.99558383
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99392477
75NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99297725
76NOTCH1_21737748_ChIP-Seq_TLL_Human0.97229321
77TFEB_21752829_ChIP-Seq_HELA_Human0.96381012
78PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95596407
79KDM5A_27292631_Chip-Seq_BREAST_Human0.95360084
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94473320
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94213594
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93210631
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92477735
84MYC_18940864_ChIP-ChIP_HL60_Human0.89425987
85REST_19997604_ChIP-ChIP_NEURONS_Mouse0.87671852
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.86983441
87YY1_21170310_ChIP-Seq_MESCs_Mouse0.86962995
88CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.85705438
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84926793
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84851008
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82451162
92CIITA_25753668_ChIP-Seq_RAJI_Human0.81424132
93SOX9_26525672_Chip-Seq_HEART_Mouse0.79619509
94FLI1_27457419_Chip-Seq_LIVER_Mouse0.78128317
95TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78073528
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.77302953
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.76722027
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76117347
99GBX2_23144817_ChIP-Seq_PC3_Human0.76109033
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75391040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.76452282
2MP0003693_abnormal_embryo_hatching3.51796617
3MP0010094_abnormal_chromosome_stability3.45540586
4MP0003111_abnormal_nucleus_morphology3.32096397
5MP0004957_abnormal_blastocyst_morpholog3.22601860
6MP0002102_abnormal_ear_morphology3.21074604
7MP0008058_abnormal_DNA_repair3.10282189
8MP0003077_abnormal_cell_cycle2.77757942
9MP0008932_abnormal_embryonic_tissue2.28223286
10MP0001730_embryonic_growth_arrest2.03287484
11MP0001293_anophthalmia2.00572220
12MP0003890_abnormal_embryonic-extraembry1.87706544
13MP0008877_abnormal_DNA_methylation1.74210224
14MP0001529_abnormal_vocalization1.73782789
15MP0003941_abnormal_skin_development1.72006329
16MP0008007_abnormal_cellular_replicative1.68810014
17MP0005380_embryogenesis_phenotype1.66937787
18MP0001672_abnormal_embryogenesis/_devel1.66937787
19MP0005408_hypopigmentation1.66617857
20MP0001697_abnormal_embryo_size1.64836742
21MP0009672_abnormal_birth_weight1.63890668
22MP0003121_genomic_imprinting1.59536109
23MP0002084_abnormal_developmental_patter1.58592154
24MP0003718_maternal_effect1.57666942
25MP0003937_abnormal_limbs/digits/tail_de1.49672464
26MP0004197_abnormal_fetal_growth/weight/1.46487187
27MP0002085_abnormal_embryonic_tissue1.45481713
28MP0002233_abnormal_nose_morphology1.44674822
29MP0000350_abnormal_cell_proliferation1.43018504
30MP0002697_abnormal_eye_size1.42679790
31MP0003984_embryonic_growth_retardation1.42087858
32MP0002088_abnormal_embryonic_growth/wei1.39835555
33MP0003567_abnormal_fetal_cardiomyocyte1.38325639
34MP0002080_prenatal_lethality1.32183118
35MP0004233_abnormal_muscle_weight1.31066105
36MP0003880_abnormal_central_pattern1.30039691
37MP0009697_abnormal_copulation1.28391492
38MP0005248_abnormal_Harderian_gland1.27800640
39MP0010307_abnormal_tumor_latency1.24581142
40MP0006035_abnormal_mitochondrial_morpho1.23714790
41MP0003123_paternal_imprinting1.22744693
42MP0008789_abnormal_olfactory_epithelium1.22593931
43MP0010352_gastrointestinal_tract_polyps1.22486019
44MP0001286_abnormal_eye_development1.21321796
45MP0009703_decreased_birth_body1.18837829
46MP0000647_abnormal_sebaceous_gland1.15733737
47MP0003221_abnormal_cardiomyocyte_apopto1.15610659
48MP0000751_myopathy1.15148658
49MP0002269_muscular_atrophy1.14965478
50MP0003122_maternal_imprinting1.13452517
51MP0000372_irregular_coat_pigmentation1.11162386
52MP0000569_abnormal_digit_pigmentation1.10787163
53MP0010030_abnormal_orbit_morphology1.10720283
54MP0003119_abnormal_digestive_system1.10663449
55MP0001929_abnormal_gametogenesis1.08569385
56MP0006072_abnormal_retinal_apoptosis1.06951345
57MP0002938_white_spotting1.03833295
58MP0003385_abnormal_body_wall1.03380340
59MP0003861_abnormal_nervous_system1.02196502
60MP0002092_abnormal_eye_morphology1.01622935
61MP0006036_abnormal_mitochondrial_physio1.00600571
62MP0003755_abnormal_palate_morphology0.99586850
63MP0005394_taste/olfaction_phenotype0.99404052
64MP0005499_abnormal_olfactory_system0.99404052
65MP0002751_abnormal_autonomic_nervous0.98798977
66MP0003935_abnormal_craniofacial_develop0.98206497
67MP0002086_abnormal_extraembryonic_tissu0.95380507
68MP0000358_abnormal_cell_content/0.92629565
69MP0001299_abnormal_eye_distance/0.91269880
70MP0006292_abnormal_olfactory_placode0.89931190
71MP0004215_abnormal_myocardial_fiber0.89780524
72MP0005391_vision/eye_phenotype0.88213696
73MP0000749_muscle_degeneration0.87211042
74MP0003646_muscle_fatigue0.86069491
75MP0000015_abnormal_ear_pigmentation0.85156295
76MP0002177_abnormal_outer_ear0.84954810
77MP0002210_abnormal_sex_determination0.83935115
78MP0001324_abnormal_eye_pigmentation0.83671893
79MP0005253_abnormal_eye_physiology0.83187835
80MP0000516_abnormal_urinary_system0.82631815
81MP0005367_renal/urinary_system_phenotyp0.82631815
82MP0001661_extended_life_span0.82384452
83MP0003787_abnormal_imprinting0.81857891
84MP0003943_abnormal_hepatobiliary_system0.79298544
85MP0000313_abnormal_cell_death0.79190976
86MP0004270_analgesia0.78822744
87MP0002877_abnormal_melanocyte_morpholog0.77765418
88MP0001188_hyperpigmentation0.77701173
89MP0002111_abnormal_tail_morphology0.77290715
90MP0005171_absent_coat_pigmentation0.76163319
91MP0002114_abnormal_axial_skeleton0.76145030
92MP0001177_atelectasis0.75603960
93MP0000778_abnormal_nervous_system0.75506155
94MP0000566_synostosis0.74984224
95MP0000049_abnormal_middle_ear0.73445942
96MP0000747_muscle_weakness0.72330536
97MP0005623_abnormal_meninges_morphology0.71720964
98MP0005187_abnormal_penis_morphology0.71256386
99MP0003698_abnormal_male_reproductive0.71252254
100MP0002081_perinatal_lethality0.71049970

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.09093607
2Chromsome breakage (HP:0040012)3.64369713
3Ependymoma (HP:0002888)3.40182255
4Cortical dysplasia (HP:0002539)3.24182342
5Meckel diverticulum (HP:0002245)3.18493361
6Abnormality of chromosome stability (HP:0003220)3.07730933
7Abnormality of the astrocytes (HP:0100707)2.98772057
8Astrocytoma (HP:0009592)2.98772057
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.92546012
10Abnormality of the ileum (HP:0001549)2.88987786
11Exercise-induced muscle cramps (HP:0003710)2.86599551
12Microvesicular hepatic steatosis (HP:0001414)2.79512170
13Abnormal lung lobation (HP:0002101)2.70257370
14Abnormality of the preputium (HP:0100587)2.59271795
15Glioma (HP:0009733)2.53366913
16Duodenal stenosis (HP:0100867)2.51547886
17Small intestinal stenosis (HP:0012848)2.51547886
18Abnormality of the labia minora (HP:0012880)2.49811773
19Medulloblastoma (HP:0002885)2.43216564
20Nephroblastoma (Wilms tumor) (HP:0002667)2.41741174
21Embryonal renal neoplasm (HP:0011794)2.38589708
22Volvulus (HP:0002580)2.38470306
23Abnormality of the duodenum (HP:0002246)2.35312848
24Shoulder girdle muscle weakness (HP:0003547)2.35236794
25Abnormality of chromosome segregation (HP:0002916)2.34535615
26Colon cancer (HP:0003003)2.28356305
27Abnormality of the hip-girdle musculature (HP:0001445)2.25908788
28Abnormality of the musculature of the pelvis (HP:0001469)2.25908788
29Increased nuchal translucency (HP:0010880)2.25732108
30Pheochromocytoma (HP:0002666)2.23030151
31Ectopic kidney (HP:0000086)2.21343397
32Bifid tongue (HP:0010297)2.16771534
33Hyperglycinuria (HP:0003108)2.15622094
34Hepatoblastoma (HP:0002884)2.15615774
35Papillary thyroid carcinoma (HP:0002895)2.07491389
36Selective tooth agenesis (HP:0001592)2.02082330
37Neuroendocrine neoplasm (HP:0100634)2.00706660
38Myelodysplasia (HP:0002863)2.00542225
39Pelvic girdle muscle weakness (HP:0003749)1.96199528
40Renal hypoplasia (HP:0000089)1.95472392
41Aplasia/Hypoplasia of the sternum (HP:0006714)1.94262876
42Absent radius (HP:0003974)1.91819587
43Abnormality of glycolysis (HP:0004366)1.90237102
44Sloping forehead (HP:0000340)1.89744744
45Hyperglycinemia (HP:0002154)1.89728760
46Partial agenesis of the corpus callosum (HP:0001338)1.89697543
47Nemaline bodies (HP:0003798)1.89674534
48Hypopigmentation of the fundus (HP:0007894)1.89524918
49Rimmed vacuoles (HP:0003805)1.88643097
50Progressive external ophthalmoplegia (HP:0000590)1.88500959
51Progressive inability to walk (HP:0002505)1.87036114
52Overlapping toe (HP:0001845)1.86459837
53Tubulointerstitial nephritis (HP:0001970)1.85926815
54Intestinal atresia (HP:0011100)1.84430419
55Hemiparesis (HP:0001269)1.82923045
56Facial cleft (HP:0002006)1.81499353
57Retinal dysplasia (HP:0007973)1.80922570
58Aplasia involving forearm bones (HP:0009822)1.80210048
59Absent forearm bone (HP:0003953)1.80210048
60Cafe-au-lait spot (HP:0000957)1.79751996
61Postnatal microcephaly (HP:0005484)1.79608546
62Exercise-induced myalgia (HP:0003738)1.78937546
63Cerebellar dysplasia (HP:0007033)1.78766582
64Spastic diplegia (HP:0001264)1.78061152
65Birth length less than 3rd percentile (HP:0003561)1.77645337
66Microglossia (HP:0000171)1.76700161
67Neoplasm of the adrenal gland (HP:0100631)1.76463929
68Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76401625
69Increased serum pyruvate (HP:0003542)1.76172745
70Muscle fiber inclusion bodies (HP:0100299)1.74188289
71Supernumerary spleens (HP:0009799)1.71908802
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69795395
73Abnormality of the carotid arteries (HP:0005344)1.69269348
74Nervous tissue neoplasm (HP:0030060)1.68704599
75Neuroectodermal neoplasm (HP:0030061)1.68704599
76Neuroepithelial neoplasm (HP:0030063)1.68704599
77Abnormality of the antihelix (HP:0009738)1.68571424
78Rhabdomyosarcoma (HP:0002859)1.68570131
79Abnormal number of incisors (HP:0011064)1.67800562
80Proximal placement of thumb (HP:0009623)1.67616286
81Gout (HP:0001997)1.66540703
82Insidious onset (HP:0003587)1.64537027
83Termporal pattern (HP:0011008)1.64537027
84Abnormality of serum amino acid levels (HP:0003112)1.64405992
85Embryonal neoplasm (HP:0002898)1.63417337
86Abnormality of glycine metabolism (HP:0010895)1.61794244
87Abnormality of serine family amino acid metabolism (HP:0010894)1.61794244
88Triphalangeal thumb (HP:0001199)1.61075820
89Thyroid carcinoma (HP:0002890)1.59911968
90Failure to thrive in infancy (HP:0001531)1.59646159
91Neoplasm of striated muscle (HP:0009728)1.58455004
92Abnormal auditory evoked potentials (HP:0006958)1.58390938
93Abnormality of the left ventricular outflow tract (HP:0011103)1.57750600
94Subaortic stenosis (HP:0001682)1.57750600
95Neoplasm of the peripheral nervous system (HP:0100007)1.56815214
96Bicornuate uterus (HP:0000813)1.55992668
97Neoplasm of the colon (HP:0100273)1.54283627
98Cutaneous melanoma (HP:0012056)1.53186050
99Proximal amyotrophy (HP:0007126)1.52705196
100Deviation of the thumb (HP:0009603)1.51405283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK3.95395792
2EIF2AK13.48940010
3SRPK13.23106731
4TRIM282.97736019
5BRD42.93784531
6BUB12.92149955
7TSSK62.91556891
8PNCK2.86112974
9PLK42.66966898
10TTK2.66711549
11CDC72.54030322
12EIF2AK32.41626187
13NEK12.20115854
14WEE12.07946703
15MKNK22.04246288
16WNK32.02597565
17PLK31.88781229
18BCR1.86355316
19MKNK11.74136374
20MAP3K101.71748367
21CDK121.63384775
22LATS11.62009357
23MAP3K41.54045726
24DMPK1.44706363
25PLK11.38955842
26TNIK1.35476883
27MST41.30741518
28OBSCN1.21507271
29PLK21.18373177
30ATR1.12733918
31STK38L1.12146980
32ERBB31.10921116
33BRSK21.06239525
34ACVR1B1.05652427
35CHEK21.04106745
36NUAK11.03572749
37BMPR1B0.99627087
38ERBB40.96654715
39ZAK0.96156679
40ATM0.95917595
41CDK70.95198639
42CAMK1G0.94936231
43CHEK10.92718835
44LATS20.92123990
45CSNK1G10.91761708
46EIF2AK20.86112014
47SCYL20.85129636
48CSNK1A1L0.83616078
49STK160.81860676
50INSRR0.80150700
51NEK20.80022997
52ALK0.79406876
53MAP2K70.78772241
54AURKB0.77995293
55CDK60.77791167
56FGFR10.75774188
57MET0.75578504
58DYRK30.75357501
59CSNK1G30.74030756
60CDK30.72753628
61RPS6KA40.71681197
62CDK90.71219083
63VRK10.70274384
64SIK30.70097152
65CSNK1G20.68765191
66AKT20.67172247
67CDK80.64697192
68AURKA0.63336742
69CDK10.61004271
70PDK20.60778899
71DYRK20.59197770
72FGFR30.59150512
73MAP3K120.58298174
74CDK20.58260303
75STK30.57981547
76MELK0.57098193
77VRK20.55383587
78STK390.53601409
79CSNK1E0.49630192
80CDK40.48914424
81NME10.47901657
82AKT30.47390006
83BRSK10.46942464
84TAF10.43420269
85FGFR20.43202385
86EPHA40.42998834
87PRKDC0.41121300
88DYRK1A0.40568475
89PHKG10.40312671
90PHKG20.40312671
91CASK0.38928760
92CSNK2A20.36930142
93MAP2K40.36416765
94NEK60.35602495
95PRKCE0.33093861
96CSNK1D0.32821116
97PASK0.31982282
98NEK90.30896857
99KSR10.30443938
100MAPK140.30109383

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.24772940
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20677831
3Mismatch repair_Homo sapiens_hsa034302.96259314
4DNA replication_Homo sapiens_hsa030302.88962529
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.87265585
6RNA transport_Homo sapiens_hsa030132.85547491
7Protein export_Homo sapiens_hsa030602.80430250
8Proteasome_Homo sapiens_hsa030502.68241590
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61950012
10Cell cycle_Homo sapiens_hsa041102.55264796
11Spliceosome_Homo sapiens_hsa030402.42510647
12Basal transcription factors_Homo sapiens_hsa030222.33812061
13Base excision repair_Homo sapiens_hsa034102.23527017
14Fanconi anemia pathway_Homo sapiens_hsa034602.19883802
15Steroid biosynthesis_Homo sapiens_hsa001002.13456924
16RNA degradation_Homo sapiens_hsa030182.09784552
17Nucleotide excision repair_Homo sapiens_hsa034202.04037210
18mRNA surveillance pathway_Homo sapiens_hsa030152.03901447
19Homologous recombination_Homo sapiens_hsa034402.00838648
20RNA polymerase_Homo sapiens_hsa030202.00454272
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91576073
22Propanoate metabolism_Homo sapiens_hsa006401.81621017
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79601478
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79003206
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.71889998
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.66974389
27One carbon pool by folate_Homo sapiens_hsa006701.52570707
28Biosynthesis of amino acids_Homo sapiens_hsa012301.45745051
29Selenocompound metabolism_Homo sapiens_hsa004501.44706194
30Carbon metabolism_Homo sapiens_hsa012001.42103064
31Oocyte meiosis_Homo sapiens_hsa041141.40863498
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33644256
33Pyruvate metabolism_Homo sapiens_hsa006201.28625283
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26906742
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.12973140
36p53 signaling pathway_Homo sapiens_hsa041151.09657433
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06170805
38Pyrimidine metabolism_Homo sapiens_hsa002401.02616685
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01197736
40Fatty acid elongation_Homo sapiens_hsa000621.00067942
41Pentose phosphate pathway_Homo sapiens_hsa000300.96865170
42Purine metabolism_Homo sapiens_hsa002300.91882995
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91813519
44Adherens junction_Homo sapiens_hsa045200.90625332
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83257232
46Hippo signaling pathway_Homo sapiens_hsa043900.79500584
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79492211
48Fatty acid metabolism_Homo sapiens_hsa012120.78733182
49Lysine degradation_Homo sapiens_hsa003100.78724178
50TGF-beta signaling pathway_Homo sapiens_hsa043500.77556311
51Huntingtons disease_Homo sapiens_hsa050160.75751674
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75233014
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71163521
54Butanoate metabolism_Homo sapiens_hsa006500.71094916
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68657385
56Fatty acid degradation_Homo sapiens_hsa000710.68295815
57Arginine and proline metabolism_Homo sapiens_hsa003300.62120822
58Wnt signaling pathway_Homo sapiens_hsa043100.60007868
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56181938
60Hedgehog signaling pathway_Homo sapiens_hsa043400.55542919
61Parkinsons disease_Homo sapiens_hsa050120.55441856
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53384780
63Colorectal cancer_Homo sapiens_hsa052100.50906945
64Folate biosynthesis_Homo sapiens_hsa007900.50349341
65N-Glycan biosynthesis_Homo sapiens_hsa005100.47933412
66Basal cell carcinoma_Homo sapiens_hsa052170.47852354
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46864245
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44166936
69Tight junction_Homo sapiens_hsa045300.43687491
70beta-Alanine metabolism_Homo sapiens_hsa004100.42676324
71Prostate cancer_Homo sapiens_hsa052150.42257757
72MicroRNAs in cancer_Homo sapiens_hsa052060.41937070
73Thyroid cancer_Homo sapiens_hsa052160.39781737
74Metabolic pathways_Homo sapiens_hsa011000.38770721
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35838938
76Peroxisome_Homo sapiens_hsa041460.35153824
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32682972
78Epstein-Barr virus infection_Homo sapiens_hsa051690.29420552
79Small cell lung cancer_Homo sapiens_hsa052220.29406426
80Sulfur relay system_Homo sapiens_hsa041220.26811174
81Sphingolipid metabolism_Homo sapiens_hsa006000.24607860
82Oxidative phosphorylation_Homo sapiens_hsa001900.23632352
83Viral carcinogenesis_Homo sapiens_hsa052030.23567811
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.22674796
85Vitamin B6 metabolism_Homo sapiens_hsa007500.20479574
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20416751
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18809843
88Phototransduction_Homo sapiens_hsa047440.17914460
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.16620895
90Melanoma_Homo sapiens_hsa052180.16292806
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.15938329
92AMPK signaling pathway_Homo sapiens_hsa041520.15471566
93Inositol phosphate metabolism_Homo sapiens_hsa005620.14776466
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13294761
95Alcoholism_Homo sapiens_hsa050340.13096004
96Arginine biosynthesis_Homo sapiens_hsa002200.12489293
97mTOR signaling pathway_Homo sapiens_hsa041500.12340447
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11806939
99Axon guidance_Homo sapiens_hsa043600.10794638
100Circadian rhythm_Homo sapiens_hsa047100.10576400

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