ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.51838932
2	viral transcription (GO:0019083)	7.11119877
3	translational termination (GO:0006415)	6.73718002
4	maturation of SSU-rRNA (GO:0030490)	6.70920018
5	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	6.28281177
6	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.04216019
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.02316172
8	translational elongation (GO:0006414)	5.95457108
9	cotranslational protein targeting to membrane (GO:0006613)	5.89525447
10	protein targeting to ER (GO:0045047)	5.88302995
11	ribosomal small subunit assembly (GO:0000028)	5.82623195
12	chaperone-mediated protein transport (GO:0072321)	5.80419700
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.62161717
14	protein localization to endoplasmic reticulum (GO:0070972)	5.58650864
15	ATP synthesis coupled proton transport (GO:0015986)	5.56606188
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.56606188
17	regulation of mitochondrial translation (GO:0070129)	5.44110214
18	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.36389091
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.29815723
20	viral life cycle (GO:0019058)	5.28507601
21	cellular protein complex disassembly (GO:0043624)	5.20125700
22	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.14006755
23	translational initiation (GO:0006413)	4.87030214
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.83217700
25	protein complex biogenesis (GO:0070271)	4.82030777
26	ribonucleoprotein complex biogenesis (GO:0022613)	4.78211587
27	respiratory electron transport chain (GO:0022904)	4.71708869
28	translation (GO:0006412)	4.65453802
29	mitochondrial respiratory chain complex assembly (GO:0033108)	4.64862282
30	electron transport chain (GO:0022900)	4.59928932
31	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	4.57499498
32	cellular component biogenesis (GO:0044085)	4.55043128
33	protein complex disassembly (GO:0043241)	4.51750677
34	pyrimidine nucleotide catabolic process (GO:0006244)	4.50306121
35	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.48400840
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.48400840
37	NADH dehydrogenase complex assembly (GO:0010257)	4.48400840
38	GTP biosynthetic process (GO:0006183)	4.46403449
39	ribosomal large subunit biogenesis (GO:0042273)	4.42241150
40	protein targeting to mitochondrion (GO:0006626)	4.39400411
41	oxidative phosphorylation (GO:0006119)	4.36189991
42	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.28936736
43	UTP biosynthetic process (GO:0006228)	4.27998313
44	macromolecular complex disassembly (GO:0032984)	4.26963549
45	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	4.20408859
46	pseudouridine synthesis (GO:0001522)	4.14576306
47	guanosine-containing compound biosynthetic process (GO:1901070)	4.10801108
48	establishment of protein localization to mitochondrion (GO:0072655)	4.06189553
49	protein targeting to membrane (GO:0006612)	4.03068442
50	proteasome assembly (GO:0043248)	4.02441376
51	nucleobase-containing small molecule interconversion (GO:0015949)	3.97909660
52	deoxyribose phosphate biosynthetic process (GO:0046385)	3.97010278
53	2-deoxyribonucleotide biosynthetic process (GO:0009265)	3.97010278
54	UTP metabolic process (GO:0046051)	3.91515169
55	CTP biosynthetic process (GO:0006241)	3.90310484
56	CTP metabolic process (GO:0046036)	3.90310484
57	deoxyribonucleotide catabolic process (GO:0009264)	3.89444704
58	protein localization to mitochondrion (GO:0070585)	3.83223050
59	base-excision repair, AP site formation (GO:0006285)	3.80892596
60	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.80134162
61	rRNA processing (GO:0006364)	3.77767235
62	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.73915756
63	deoxyribose phosphate catabolic process (GO:0046386)	3.73594650
64	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.72008543
65	ribosome biogenesis (GO:0042254)	3.70693768
66	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.69494760
67	peptidyl-histidine modification (GO:0018202)	3.68767971
68	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	3.61296316
69	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.60381452
70	rRNA metabolic process (GO:0016072)	3.59503950
71	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.55771011
72	termination of RNA polymerase III transcription (GO:0006386)	3.53583364
73	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.53583364
74	ATP biosynthetic process (GO:0006754)	3.51024906
75	mRNA catabolic process (GO:0006402)	3.49634519
76	iron-sulfur cluster assembly (GO:0016226)	3.46720050
77	metallo-sulfur cluster assembly (GO:0031163)	3.46720050
78	rRNA modification (GO:0000154)	3.41595451
79	cytochrome complex assembly (GO:0017004)	3.41400727
80	2-deoxyribonucleotide metabolic process (GO:0009394)	3.38558854
81	telomere maintenance via semi-conservative replication (GO:0032201)	3.37246177
82	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.36441600
83	protein neddylation (GO:0045116)	3.34994891
84	protein maturation by protein folding (GO:0022417)	3.32919317
85	mitochondrial transport (GO:0006839)	3.32387297
86	formation of translation preinitiation complex (GO:0001731)	3.32230044
87	RNA catabolic process (GO:0006401)	3.30968859
88	nucleoside triphosphate biosynthetic process (GO:0009142)	3.29373377
89	ncRNA 3-end processing (GO:0043628)	3.24213419
90	kinetochore assembly (GO:0051382)	3.20526570
91	deoxyribose phosphate metabolic process (GO:0019692)	3.19270606
92	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18724290
93	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18724290
94	DNA strand elongation involved in DNA replication (GO:0006271)	3.18355326
95	pyrimidine nucleotide metabolic process (GO:0006220)	3.15068148
96	negative regulation of RNA splicing (GO:0033119)	3.11894782
97	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.10340874
98	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.09959860
99	DNA strand elongation (GO:0022616)	3.09776796
100	respiratory chain complex IV assembly (GO:0008535)	3.07096498

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.30922234
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.89947183
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.76068275
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.75365052
5	E2F7_22180533_ChIP-Seq_HELA_Human	3.63311091
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.47373382
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.30018427
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	3.24760986
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.16533215
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.00982292
11	XRN2_22483619_ChIP-Seq_HELA_Human	2.73896041
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.70139114
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68479597
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.66466377
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.61666319
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60626221
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.60019572
18	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.59931742
19	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.58232321
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.54237849
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.42474577
22	GABP_19822575_ChIP-Seq_HepG2_Human	2.21239914
23	DCP1A_22483619_ChIP-Seq_HELA_Human	2.14722580
24	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.14550155
25	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.12043823
26	TTF2_22483619_ChIP-Seq_HELA_Human	2.08411790
27	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.01398462
28	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.00063192
29	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.90442731
30	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.90298324
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85762510
32	ZNF263_19887448_ChIP-Seq_K562_Human	1.85743954
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.82162477
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.81046891
35	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.78660435
36	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.78124622
37	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.77895169
38	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.77828125
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77772382
40	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.77115978
41	* VDR_21846776_ChIP-Seq_THP-1_Human	1.75414978
42	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.64531377
43	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.60549704
44	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59235677
45	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.57075667
46	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.53385711
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.52305351
48	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.49152795
49	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.47154550
50	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.44589291
51	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.42713691
52	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.41270937
53	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.36379860
54	KDM5A_27292631_Chip-Seq_BREAST_Human	1.35297121
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.34949409
56	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.34775240
57	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.31508726
58	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.31352492
59	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.31167491
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31153158
61	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.31006782
62	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.30807390
63	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.30594224
64	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.29972546
65	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29646951
66	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.27748685
67	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.26395899
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26081809
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.23247177
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.18698817
71	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.18285236
72	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.17370036
73	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16236149
74	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13865365
75	* LXR_22292898_ChIP-Seq_THP-1_Human	1.12675539
76	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.09873762
77	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.08725829
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.07865221
79	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.07096453
80	P68_20966046_ChIP-Seq_HELA_Human	1.06996690
81	BCL6_27268052_Chip-Seq_Bcells_Human	1.04205291
82	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.03286479
83	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.03112280
84	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.99736653
85	MYC_22102868_ChIP-Seq_BL_Human	0.99672374
86	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.97310479
87	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96321242
88	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.93588423
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.93475875
90	* SA1_27219007_Chip-Seq_ERYTHROID_Human	0.93203853
91	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.93176755
92	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.92767897
93	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.92604598
94	* CTCF_21964334_Chip-Seq_Bcells_Human	0.91836901
95	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.88587816
96	MAF_26560356_Chip-Seq_TH2_Human	0.86437129
97	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.86265712
98	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.86161994
99	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.85606493
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.83490601

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.53335615
2	MP0003693_abnormal_embryo_hatching	3.79812855
3	MP0002163_abnormal_gland_morphology	3.38349693
4	MP0003111_abnormal_nucleus_morphology	3.09818002
5	MP0002234_abnormal_pharynx_morphology	3.06283337
6	MP0003806_abnormal_nucleotide_metabolis	3.05228208
7	MP0003186_abnormal_redox_activity	3.03321765
8	MP0006292_abnormal_olfactory_placode	2.96750095
9	MP0008932_abnormal_embryonic_tissue	2.82287721
10	MP0006036_abnormal_mitochondrial_physio	2.81777019
11	MP0008058_abnormal_DNA_repair	2.69691642
12	MP0010094_abnormal_chromosome_stability	2.68546916
13	MP0004957_abnormal_blastocyst_morpholog	2.58954339
14	MP0002132_abnormal_respiratory_system	2.32667144
15	MP0003077_abnormal_cell_cycle	2.32589731
16	MP0003786_premature_aging	2.24177940
17	MP0000678_abnormal_parathyroid_gland	2.21965957
18	MP0008007_abnormal_cellular_replicative	2.16444064
19	MP0000049_abnormal_middle_ear	2.11266461
20	MP0008789_abnormal_olfactory_epithelium	2.04602448
21	MP0010030_abnormal_orbit_morphology	1.98297346
22	MP0002160_abnormal_reproductive_system	1.78943702
23	MP0003123_paternal_imprinting	1.75262082
24	MP0001905_abnormal_dopamine_level	1.63466324
25	MP0000372_irregular_coat_pigmentation	1.62501325
26	MP0009333_abnormal_splenocyte_physiolog	1.61922405
27	MP0005379_endocrine/exocrine_gland_phen	1.59431191
28	MP0005394_taste/olfaction_phenotype	1.56605118
29	MP0005499_abnormal_olfactory_system	1.56605118
30	MP0004858_abnormal_nervous_system	1.53871440
31	MP0002877_abnormal_melanocyte_morpholog	1.48148307
32	MP0006035_abnormal_mitochondrial_morpho	1.41727011
33	MP0000350_abnormal_cell_proliferation	1.39445318
34	MP0001529_abnormal_vocalization	1.38099810
35	MP0002837_dystrophic_cardiac_calcinosis	1.33581966
36	MP0000750_abnormal_muscle_regeneration	1.29194081
37	MP0005389_reproductive_system_phenotype	1.29193381
38	MP0002249_abnormal_larynx_morphology	1.25614456
39	MP0005501_abnormal_skin_physiology	1.22138777
40	MP0004145_abnormal_muscle_electrophysio	1.21385223
41	MP0000313_abnormal_cell_death	1.21205858
42	MP0005451_abnormal_body_composition	1.20587239
43	MP0009250_abnormal_appendicular_skeleto	1.20466606
44	MP0001727_abnormal_embryo_implantation	1.16921211
45	MP0005670_abnormal_white_adipose	1.16819121
46	MP0002938_white_spotting	1.16572135
47	MP0003718_maternal_effect	1.14609462
48	MP0003136_yellow_coat_color	1.13940280
49	MP0001293_anophthalmia	1.13201077
50	MP0000358_abnormal_cell_content/	1.11486416
51	MP0000490_abnormal_crypts_of	1.11207591
52	MP0009053_abnormal_anal_canal	1.09669086
53	MP0001919_abnormal_reproductive_system	1.09113372
54	MP0003315_abnormal_perineum_morphology	1.08711947
55	MP0002736_abnormal_nociception_after	1.08060308
56	MP0005330_cardiomyopathy	1.05955119
57	MP0002822_catalepsy	1.05067018
58	MP0004185_abnormal_adipocyte_glucose	1.04931233
59	MP0005623_abnormal_meninges_morphology	1.04418173
60	MP0000681_abnormal_thyroid_gland	1.04063578
61	MP0001881_abnormal_mammary_gland	1.02307068
62	MP0005408_hypopigmentation	1.01400508
63	MP0001764_abnormal_homeostasis	0.96425710
64	MP0001661_extended_life_span	0.94944857
65	MP0004233_abnormal_muscle_weight	0.93656869
66	MP0002019_abnormal_tumor_incidence	0.87896973
67	MP0009697_abnormal_copulation	0.87841239
68	MP0003137_abnormal_impulse_conducting	0.86187439
69	MP0003011_delayed_dark_adaptation	0.83869532
70	MP0005332_abnormal_amino_acid	0.81754592
71	MP0002210_abnormal_sex_determination	0.80786819
72	MP0001730_embryonic_growth_arrest	0.76859603
73	MP0005646_abnormal_pituitary_gland	0.72938161
74	MP0001873_stomach_inflammation	0.72285471
75	MP0001346_abnormal_lacrimal_gland	0.71407031
76	MP0002177_abnormal_outer_ear	0.71270191
77	MP0005266_abnormal_metabolism	0.70516901
78	MP0000343_altered_response_to	0.70453328
79	MP0000759_abnormal_skeletal_muscle	0.67684231
80	MP0002080_prenatal_lethality	0.65327490
81	MP0002697_abnormal_eye_size	0.65030110
82	MP0004142_abnormal_muscle_tone	0.64876199
83	MP0010307_abnormal_tumor_latency	0.64434075
84	MP0001697_abnormal_embryo_size	0.64386915
85	MP0002092_abnormal_eye_morphology	0.64200121
86	MP0005377_hearing/vestibular/ear_phenot	0.63376234
87	MP0003878_abnormal_ear_physiology	0.63376234
88	MP0002095_abnormal_skin_pigmentation	0.62534963
89	MP0001188_hyperpigmentation	0.62322178
90	MP0008873_increased_physiological_sensi	0.60610744
91	MP0003942_abnormal_urinary_system	0.59478071
92	MP0000762_abnormal_tongue_morphology	0.59449335
93	MP0003646_muscle_fatigue	0.59254797
94	MP0002233_abnormal_nose_morphology	0.58498412
95	MP0005083_abnormal_biliary_tract	0.58133183
96	MP0001145_abnormal_male_reproductive	0.57859225
97	MP0001542_abnormal_bone_strength	0.56233848
98	MP0002277_abnormal_respiratory_mucosa	0.56092400
99	MP0000858_altered_metastatic_potential	0.55659429
100	MP0000703_abnormal_thymus_morphology	0.54134587

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal mitochondria in muscle tissue (HP:0008316)	6.63883353
2	Acute necrotizing encephalopathy (HP:0006965)	6.55343820
3	Acute encephalopathy (HP:0006846)	5.65670454
4	Mitochondrial inheritance (HP:0001427)	5.64396083
5	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	5.41479132
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	5.41479132
7	Progressive macrocephaly (HP:0004481)	5.19658534
8	Increased CSF lactate (HP:0002490)	5.01097702
9	Hepatocellular necrosis (HP:0001404)	4.96958837
10	Increased intramyocellular lipid droplets (HP:0012240)	4.90406453
11	Reticulocytopenia (HP:0001896)	4.80028102
12	Abnormality of cells of the erythroid lineage (HP:0012130)	4.58377563
13	Hepatic necrosis (HP:0002605)	4.55162951
14	Increased muscle lipid content (HP:0009058)	4.36631131
15	Cerebral edema (HP:0002181)	4.25860669
16	Macrocytic anemia (HP:0001972)	4.21613921
17	Abnormal number of erythroid precursors (HP:0012131)	3.95837168
18	3-Methylglutaconic aciduria (HP:0003535)	3.84475188
19	Increased hepatocellular lipid droplets (HP:0006565)	3.82929624
20	Exercise intolerance (HP:0003546)	3.76533390
21	Lactic acidosis (HP:0003128)	3.75863781
22	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.60984903
23	Increased serum lactate (HP:0002151)	3.52975656
24	Lipid accumulation in hepatocytes (HP:0006561)	3.52675170
25	Renal Fanconi syndrome (HP:0001994)	3.51523866
26	Respiratory failure (HP:0002878)	3.49193459
27	Microretrognathia (HP:0000308)	3.39837082
28	Respiratory difficulties (HP:0002880)	3.28854192
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.18104734
30	Pallor (HP:0000980)	3.06048943
31	Ragged-red muscle fibers (HP:0003200)	3.00996583
32	Leukodystrophy (HP:0002415)	2.91688343
33	Progressive muscle weakness (HP:0003323)	2.83374686
34	Microvesicular hepatic steatosis (HP:0001414)	2.77157693
35	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.69539034
36	Type I transferrin isoform profile (HP:0003642)	2.59255450
37	Muscle fiber atrophy (HP:0100295)	2.55556930
38	Exertional dyspnea (HP:0002875)	2.52419880
39	Testicular atrophy (HP:0000029)	2.46660300
40	Lethargy (HP:0001254)	2.40018223
41	Aplastic anemia (HP:0001915)	2.34851208
42	Hypoplastic left heart (HP:0004383)	2.29527868
43	Pancytopenia (HP:0001876)	2.28287792
44	Increased serum pyruvate (HP:0003542)	2.27494800
45	Emotional lability (HP:0000712)	2.22466631
46	Optic disc pallor (HP:0000543)	2.21291843
47	Absent thumb (HP:0009777)	2.20363189
48	Hyperthyroidism (HP:0000836)	2.18469836
49	Progressive microcephaly (HP:0000253)	2.17485929
50	Hyperglycinemia (HP:0002154)	2.15117327
51	Cleft eyelid (HP:0000625)	2.14528010
52	Cutaneous melanoma (HP:0012056)	2.14345107
53	Dicarboxylic aciduria (HP:0003215)	2.12179299
54	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.12179299
55	Squamous cell carcinoma (HP:0002860)	2.09992435
56	Degeneration of anterior horn cells (HP:0002398)	2.04875316
57	Abnormality of the anterior horn cell (HP:0006802)	2.04875316
58	Broad distal phalanx of finger (HP:0009836)	2.03894188
59	Achilles tendon contracture (HP:0001771)	2.03078304
60	Abnormality of glycolysis (HP:0004366)	2.02800665
61	CNS demyelination (HP:0007305)	2.02780956
62	Abnormal number of incisors (HP:0011064)	2.02172157
63	Abnormal protein glycosylation (HP:0012346)	1.97568334
64	Abnormal glycosylation (HP:0012345)	1.97568334
65	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97568334
66	Abnormal protein N-linked glycosylation (HP:0012347)	1.97568334
67	Opisthotonus (HP:0002179)	1.96825526
68	Colon cancer (HP:0003003)	1.94213161
69	Double outlet right ventricle (HP:0001719)	1.94210534
70	Congenital malformation of the right heart (HP:0011723)	1.94210534
71	Multiple enchondromatosis (HP:0005701)	1.92779927
72	Cerebral hypomyelination (HP:0006808)	1.92316496
73	X-linked dominant inheritance (HP:0001423)	1.90037818
74	Dysphonia (HP:0001618)	1.88446810
75	Hypoplasia of the radius (HP:0002984)	1.87356904
76	Hypoplastic heart (HP:0001961)	1.86316580
77	Redundant skin (HP:0001582)	1.82876696
78	Sparse eyelashes (HP:0000653)	1.82527201
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.82327188
80	Abnormality of alanine metabolism (HP:0010916)	1.82327188
81	Hyperalaninemia (HP:0003348)	1.82327188
82	Rough bone trabeculation (HP:0100670)	1.80513618
83	Trismus (HP:0000211)	1.79600508
84	Gliosis (HP:0002171)	1.79215590
85	Patent foramen ovale (HP:0001655)	1.77773015
86	Concave nail (HP:0001598)	1.77492845
87	Reduced subcutaneous adipose tissue (HP:0003758)	1.76549351
88	Gout (HP:0001997)	1.72370709
89	Horseshoe kidney (HP:0000085)	1.71811291
90	Abnormality of renal resorption (HP:0011038)	1.71521444
91	Abnormality of the Achilles tendon (HP:0005109)	1.69672382
92	Partial duplication of thumb phalanx (HP:0009944)	1.68533466
93	Reduced antithrombin III activity (HP:0001976)	1.67169497
94	Generalized aminoaciduria (HP:0002909)	1.64485428
95	Partial duplication of the phalanx of hand (HP:0009999)	1.63429922
96	Truncus arteriosus (HP:0001660)	1.63360314
97	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.58513514
98	Myokymia (HP:0002411)	1.57025460
99	Death in infancy (HP:0001522)	1.55807594
100	Blindness (HP:0000618)	1.55469911

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	6.66561985
2	VRK2	4.74743475
3	BUB1	3.07642285
4	STK16	3.04263651
5	BCKDK	2.97602609
6	PIM2	2.93875487
7	CDC7	2.76270115
8	ARAF	2.68939863
9	TESK2	2.53016165
10	KDR	2.43883533
11	ABL2	2.12272829
12	NEK1	2.11216167
13	SCYL2	2.06802247
14	MAP3K11	1.97121840
15	SMG1	1.90920133
16	IRAK3	1.89292030
17	VRK1	1.82519343
18	TESK1	1.77841215
19	AURKA	1.73021839
20	SRPK1	1.71877250
21	TLK1	1.69442993
22	NME1	1.51442933
23	LIMK1	1.43061398
24	LRRK2	1.40574369
25	MOS	1.25718890
26	PDK2	1.24763476
27	CHEK2	1.22360983
28	ZAK	1.19888310
29	CSNK1G3	1.15512702
30	TAF1	1.14920847
31	AURKB	1.14473345
32	BRAF	1.13797475
33	NUAK1	1.11316691
34	ILK	1.09501224
35	EIF2AK1	1.05879175
36	DAPK3	1.03533674
37	DYRK2	1.03202233
38	RPS6KA5	1.02506244
39	DAPK1	1.02229343
40	PLK4	1.00176740
41	TAOK2	0.98940912
42	RPS6KA4	0.98414689
43	PLK1	0.96227206
44	CSNK1A1L	0.91259908
45	ATR	0.89671064
46	CCNB1	0.87518732
47	MAP2K7	0.82794840
48	CDK8	0.82214471
49	PBK	0.82053395
50	CDK7	0.80084094
51	PRKD3	0.79543547
52	CSNK2A2	0.75880892
53	RPS6KB2	0.74898905
54	CSNK1G2	0.74699247
55	GRK5	0.72915291
56	CDK19	0.71889083
57	BRSK1	0.70640832
58	CSNK1G1	0.69028339
59	CDK4	0.68178051
60	CSNK2A1	0.67172967
61	GRK7	0.64761400
62	DMPK	0.64511512
63	DYRK3	0.63481010
64	PAK1	0.62625692
65	CHEK1	0.62140663
66	CAMK2G	0.60008934
67	MAPKAPK5	0.59415057
68	STK4	0.56498541
69	PRKCI	0.53853860
70	CDK11A	0.51182432
71	TTK	0.50683179
72	NEK2	0.49535058
73	CDK14	0.46402236
74	MAP3K8	0.45070774
75	CDK15	0.43773219
76	MUSK	0.41116453
77	AKT2	0.37475463
78	PIM1	0.37358743
79	CDK18	0.36975401
80	STK10	0.36856716
81	EPHA2	0.34989027
82	IKBKB	0.34117294
83	CDK2	0.33717683
84	MAP4K2	0.32832705
85	MAPK11	0.32077068
86	PLK3	0.30834301
87	IRAK2	0.29085741
88	ICK	0.28133426
89	EIF2AK2	0.27195932
90	MAPKAPK3	0.27183014
91	CAMK2D	0.27176688
92	CAMK2B	0.24978978
93	CDK9	0.24440154
94	PAK4	0.24242695
95	CSNK1A1	0.23583578
96	CSNK1E	0.22934911
97	ATM	0.22824110
98	PRKCD	0.21514018
99	RPS6KL1	0.21356931
100	RPS6KC1	0.21356931

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.40287231
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20859302
3	DNA replication_Homo sapiens_hsa03030	3.79666883
4	Parkinsons disease_Homo sapiens_hsa05012	3.66603938
5	Proteasome_Homo sapiens_hsa03050	3.39543590
6	Sulfur relay system_Homo sapiens_hsa04122	3.32319548
7	Base excision repair_Homo sapiens_hsa03410	2.89257010
8	Huntingtons disease_Homo sapiens_hsa05016	2.71719118
9	RNA polymerase_Homo sapiens_hsa03020	2.66004151
10	Pyrimidine metabolism_Homo sapiens_hsa00240	2.60830853
11	Mismatch repair_Homo sapiens_hsa03430	2.58909089
12	Alzheimers disease_Homo sapiens_hsa05010	2.54677260
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.31347476
14	Spliceosome_Homo sapiens_hsa03040	2.17541980
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17278441
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07014844
17	Homologous recombination_Homo sapiens_hsa03440	1.99150456
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.97218706
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.72919726
20	Protein export_Homo sapiens_hsa03060	1.69906849
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.64514226
22	One carbon pool by folate_Homo sapiens_hsa00670	1.55808702
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46807849
24	Purine metabolism_Homo sapiens_hsa00230	1.35094691
25	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.34922009
26	Sulfur metabolism_Homo sapiens_hsa00920	1.31437196
27	Folate biosynthesis_Homo sapiens_hsa00790	1.29005574
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24027825
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.22947476
30	RNA transport_Homo sapiens_hsa03013	1.20069377
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.19414467
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11758813
33	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.08735802
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.06717578
35	Glutathione metabolism_Homo sapiens_hsa00480	0.93581777
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93134671
37	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.92462515
38	RNA degradation_Homo sapiens_hsa03018	0.90560743
39	Fatty acid elongation_Homo sapiens_hsa00062	0.90475430
40	Metabolic pathways_Homo sapiens_hsa01100	0.85686645
41	Carbon metabolism_Homo sapiens_hsa01200	0.84925043
42	Pyruvate metabolism_Homo sapiens_hsa00620	0.84824278
43	Cell cycle_Homo sapiens_hsa04110	0.83385379
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.79184961
45	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79154654
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75349793
47	Basal transcription factors_Homo sapiens_hsa03022	0.72106890
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71660677
49	Phenylalanine metabolism_Homo sapiens_hsa00360	0.69923172
50	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66980972
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.64888475
52	Galactose metabolism_Homo sapiens_hsa00052	0.64598780
53	Peroxisome_Homo sapiens_hsa04146	0.63829758
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.63698651
55	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.60732088
56	p53 signaling pathway_Homo sapiens_hsa04115	0.60109826
57	Primary immunodeficiency_Homo sapiens_hsa05340	0.57636778
58	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.55233105
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.53746384
60	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.52793131
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.48183998
62	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.43937024
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.41636746
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40190450
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37936503
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.35197951
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.30894923
68	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.30648396
69	Bladder cancer_Homo sapiens_hsa05219	0.30417489
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.30125191
71	Alcoholism_Homo sapiens_hsa05034	0.30000713
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29490286
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22647940
74	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.21987073
75	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.20953036
76	Fatty acid degradation_Homo sapiens_hsa00071	0.19363958
77	Fatty acid metabolism_Homo sapiens_hsa01212	0.19356708
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.18226580
79	mRNA surveillance pathway_Homo sapiens_hsa03015	0.18152010
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.17153077
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.16924121
82	Collecting duct acid secretion_Homo sapiens_hsa04966	0.16917189
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.16683813
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.16443587
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.14419105
86	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.13408080
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.13300520
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.11591536
89	Herpes simplex infection_Homo sapiens_hsa05168	0.11222206
90	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.09666621
91	HTLV-I infection_Homo sapiens_hsa05166	0.08304321
92	Propanoate metabolism_Homo sapiens_hsa00640	0.06572394
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.05436559
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.02209134
95	Shigellosis_Homo sapiens_hsa05131	0.02188205
96	Regulation of autophagy_Homo sapiens_hsa04140	0.02018941
97	Oocyte meiosis_Homo sapiens_hsa04114	0.00659522
98	Steroid biosynthesis_Homo sapiens_hsa00100	-0.0166046
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	-0.0134230
100	Synaptic vesicle cycle_Homo sapiens_hsa04721	-0.0065684

C17ORF89

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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