C17ORF96

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.35362009
2regulation of vitamin metabolic process (GO:0030656)4.98373284
3regulation of cytokine secretion involved in immune response (GO:0002739)4.90522831
4regulation of chronic inflammatory response (GO:0002676)4.54913524
5NIK/NF-kappaB signaling (GO:0038061)4.51269744
6oligosaccharide catabolic process (GO:0009313)4.51230265
7myeloid dendritic cell differentiation (GO:0043011)4.47103156
8activation of MAPKKK activity (GO:0000185)4.33477746
9glycosphingolipid catabolic process (GO:0046479)4.27951091
10positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.24667878
11lipopolysaccharide-mediated signaling pathway (GO:0031663)4.20539498
12low-density lipoprotein particle clearance (GO:0034383)4.13362384
13regulation of podosome assembly (GO:0071801)4.11735965
14negative regulation of interleukin-12 production (GO:0032695)4.01369329
15positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.99595949
16negative regulation of myeloid cell apoptotic process (GO:0033033)3.98714828
17regulation of T-helper 1 cell differentiation (GO:0045625)3.92582020
18regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84150928
19positive regulation of chemokine biosynthetic process (GO:0045080)3.80830728
20response to peptidoglycan (GO:0032494)3.79683430
21glycolipid catabolic process (GO:0019377)3.79661374
22regulation of cholesterol storage (GO:0010885)3.67351932
23branching involved in labyrinthine layer morphogenesis (GO:0060670)3.63956200
24positive regulation of heat generation (GO:0031652)3.59796801
25regulation of fever generation (GO:0031620)3.56708095
26myeloid dendritic cell activation (GO:0001773)3.51183399
27modulation by symbiont of host cellular process (GO:0044068)3.49047696
28negative regulation of cytokine production involved in immune response (GO:0002719)3.38345763
29regulation of immunoglobulin secretion (GO:0051023)3.38117746
30regulation of interferon-alpha production (GO:0032647)3.36944769
31regulation of chemokine biosynthetic process (GO:0045073)3.29654971
32negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.23583908
33ceramide catabolic process (GO:0046514)3.17946754
34pinocytosis (GO:0006907)3.15920624
35germinal center formation (GO:0002467)3.15383118
36membrane lipid catabolic process (GO:0046466)3.14632090
37protein localization to endosome (GO:0036010)3.14347194
38regulation of type I interferon-mediated signaling pathway (GO:0060338)3.12531910
39regulation of heterotypic cell-cell adhesion (GO:0034114)3.12215291
40sphingolipid catabolic process (GO:0030149)3.05248249
41response to protozoan (GO:0001562)3.04550064
42regulation of mononuclear cell migration (GO:0071675)3.04232020
43CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.02136536
44protein-lipid complex assembly (GO:0065005)3.01505163
45positive regulation of NF-kappaB import into nucleus (GO:0042346)2.97303419
46dendritic cell differentiation (GO:0097028)2.97255914
47T-helper 1 type immune response (GO:0042088)2.94541692
48plasma lipoprotein particle assembly (GO:0034377)2.94531612
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.92933781
50positive regulation of hair follicle development (GO:0051798)2.92871564
51positive regulation of hair cycle (GO:0042635)2.92871564
52regulation of early endosome to late endosome transport (GO:2000641)2.90356230
53adhesion of symbiont to host (GO:0044406)2.89989043
54regulation of NFAT protein import into nucleus (GO:0051532)2.87163364
55regulation of RIG-I signaling pathway (GO:0039535)2.86159814
56monocyte chemotaxis (GO:0002548)2.84227307
57cellular response to lipopolysaccharide (GO:0071222)2.83818318
58negative regulation of amino acid transport (GO:0051956)2.83317603
59plasma lipoprotein particle clearance (GO:0034381)2.82911001
60decidualization (GO:0046697)2.80189260
61type I interferon signaling pathway (GO:0060337)2.79167847
62cellular response to type I interferon (GO:0071357)2.79167847
63positive regulation of lipid storage (GO:0010884)2.74379309
64cellular response to thyroid hormone stimulus (GO:0097067)2.74074147
65regulation of T-helper 2 cell differentiation (GO:0045628)2.72775892
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.72680899
67response to type I interferon (GO:0034340)2.72580474
68regulation of superoxide anion generation (GO:0032928)2.70521678
69cellular response to virus (GO:0098586)2.70331801
70regulation of cholesterol homeostasis (GO:2000188)2.69885429
71regulation of nitric oxide biosynthetic process (GO:0045428)2.69519315
72cellular response to nicotine (GO:0071316)2.69489399
73positive regulation of transcription factor import into nucleus (GO:0042993)2.69366539
74defense response to protozoan (GO:0042832)2.67916873
75adhesion of symbiont to host cell (GO:0044650)2.66225833
76virion attachment to host cell (GO:0019062)2.66225833
77cellular response to molecule of bacterial origin (GO:0071219)2.65259979
78positive regulation of nitric oxide biosynthetic process (GO:0045429)2.64672869
79macrophage activation involved in immune response (GO:0002281)2.63135972
80positive regulation of lymphocyte apoptotic process (GO:0070230)2.61813491
81negative regulation of nitric oxide biosynthetic process (GO:0045019)2.61100722
82dicarboxylic acid biosynthetic process (GO:0043650)2.60302105
83positive regulation of interferon-alpha production (GO:0032727)2.59364461
84regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.59332247
85very-low-density lipoprotein particle assembly (GO:0034379)2.59140719
86positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58451714
87cellular response to arsenic-containing substance (GO:0071243)2.57616891
88response to thyroid hormone (GO:0097066)2.57388299
89positive regulation of fatty acid biosynthetic process (GO:0045723)2.55734145
90positive regulation of keratinocyte differentiation (GO:0045618)2.54905198
91negative regulation of production of molecular mediator of immune response (GO:0002701)2.54871677
92positive regulation of extracellular matrix organization (GO:1903055)2.54772545
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54614807
94regulation of NF-kappaB import into nucleus (GO:0042345)2.53929968
95osteoclast differentiation (GO:0030316)2.49644616
96regulation of response to interferon-gamma (GO:0060330)2.48261281
97T cell lineage commitment (GO:0002360)2.47452360
98negative regulation of insulin receptor signaling pathway (GO:0046627)2.46448714
99positive regulation of neurotransmitter secretion (GO:0001956)2.45526030
100response to muramyl dipeptide (GO:0032495)2.45190492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.15512145
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.13375920
3EGR1_19374776_ChIP-ChIP_THP-1_Human2.83960014
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75089059
5VDR_21846776_ChIP-Seq_THP-1_Human2.56709825
6* MYC_22102868_ChIP-Seq_BL_Human2.53485875
7ZNF263_19887448_ChIP-Seq_K562_Human2.49031510
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44563937
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44017932
10LXR_22292898_ChIP-Seq_THP-1_Human2.27132743
11E2F7_22180533_ChIP-Seq_HELA_Human2.17295884
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09790597
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06146373
14BP1_19119308_ChIP-ChIP_Hs578T_Human1.97271886
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.94040680
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.94029405
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.93349307
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86135085
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85453444
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.84737025
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84437687
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83427160
23RACK7_27058665_Chip-Seq_MCF-7_Human1.78459688
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77052941
25DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.67892138
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.66671353
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66178700
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65870228
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61386713
30TCF7_22412390_ChIP-Seq_EML_Mouse1.59814454
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57171480
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.56698875
33KDM2B_26808549_Chip-Seq_DND41_Human1.55349978
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.54759841
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50039543
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49681340
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44719110
38KDM2B_26808549_Chip-Seq_K562_Human1.44508753
39IRF8_27001747_Chip-Seq_BMDM_Mouse1.38625134
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37906107
41VDR_24763502_ChIP-Seq_THP-1_Human1.37119372
42MAF_26560356_Chip-Seq_TH1_Human1.35136220
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.32363734
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31934002
45CLOCK_20551151_ChIP-Seq_293T_Human1.30446115
46HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26886202
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.26243788
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.25147906
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24303005
50MAF_26560356_Chip-Seq_TH2_Human1.23565811
51KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23311655
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23152127
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21565439
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19782892
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19684542
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18205536
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.18065955
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17138429
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16060443
60E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15856688
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15485804
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15265706
63P68_20966046_ChIP-Seq_HELA_Human1.14798450
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14036860
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.13689491
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13338892
67MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12786061
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12195341
69* ATF3_27146783_Chip-Seq_COLON_Human1.12009559
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11799212
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11625344
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11530299
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11302251
74TFEB_21752829_ChIP-Seq_HELA_Human1.10985884
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09883038
76XRN2_22483619_ChIP-Seq_HELA_Human1.09825571
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09783597
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09716546
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09598260
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08538967
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08300033
82SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07655469
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.07635339
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07618155
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07485801
86NCOR1_26117541_ChIP-Seq_K562_Human1.06719404
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06556915
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05482171
89UBF1/2_26484160_Chip-Seq_HMECs_Human1.05238930
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04418645
91KDM2B_26808549_Chip-Seq_JURKAT_Human1.03714736
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03343652
93RUNX1_22412390_ChIP-Seq_EML_Mouse1.03186727
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.03058923
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02801446
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02708747
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02262467
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01640074
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01467376
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99826339

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.40939569
2MP0005058_abnormal_lysosome_morphology4.41869307
3MP0002139_abnormal_hepatobiliary_system3.70377767
4MP0005451_abnormal_body_composition3.62775945
5MP0004510_myositis3.39175812
6MP0009840_abnormal_foam_cell3.23991105
7MP0003436_decreased_susceptibility_to2.97026409
8MP0002148_abnormal_hypersensitivity_rea2.90550569
9MP0003453_abnormal_keratinocyte_physiol2.74498835
10MP0006082_CNS_inflammation2.55516151
11MP0003172_abnormal_lysosome_physiology2.49620664
12MP0009785_altered_susceptibility_to2.47615048
13MP0003075_altered_response_to2.21789676
14MP0003300_gastrointestinal_ulcer2.17118717
15MP0001853_heart_inflammation2.14050240
16MP0005076_abnormal_cell_differentiation2.10865046
17MP0005000_abnormal_immune_tolerance2.09077805
18MP0009278_abnormal_bone_marrow2.07557443
19MP0004947_skin_inflammation2.02676020
20MP0000604_amyloidosis1.99193201
21MP0005387_immune_system_phenotype1.94306271
22MP0001790_abnormal_immune_system1.94306271
23MP0009333_abnormal_splenocyte_physiolog1.92788010
24MP0005025_abnormal_response_to1.82323089
25MP0005671_abnormal_response_to1.81344476
26MP0002877_abnormal_melanocyte_morpholog1.72336322
27MP0004185_abnormal_adipocyte_glucose1.71172007
28MP0000858_altered_metastatic_potential1.69099791
29MP0002419_abnormal_innate_immunity1.66077284
30MP0000343_altered_response_to1.63527491
31MP0001835_abnormal_antigen_presentation1.62407109
32MP0002254_reproductive_system_inflammat1.61759594
33MP0005167_abnormal_blood-brain_barrier1.59225808
34MP0001533_abnormal_skeleton_physiology1.52611415
35MP0009764_decreased_sensitivity_to1.50093193
36MP0002723_abnormal_immune_serum1.46216407
37MP0005310_abnormal_salivary_gland1.45607732
38MP0003806_abnormal_nucleotide_metabolis1.45116280
39MP0002452_abnormal_antigen_presenting1.42463291
40MP0003448_altered_tumor_morphology1.42419142
41MP0003191_abnormal_cellular_cholesterol1.35985022
42MP0008469_abnormal_protein_level1.33896921
43MP0003329_amyloid_beta_deposits1.33175028
44MP0002998_abnormal_bone_remodeling1.33086992
45MP0001845_abnormal_inflammatory_respons1.30588297
46MP0002089_abnormal_postnatal_growth/wei1.30349400
47MP0010307_abnormal_tumor_latency1.29143571
48MP0001800_abnormal_humoral_immune1.28930723
49MP0003123_paternal_imprinting1.28739241
50MP0010155_abnormal_intestine_physiology1.28636348
51MP0002405_respiratory_system_inflammati1.25404146
52MP0003705_abnormal_hypodermis_morpholog1.23514051
53MP0001545_abnormal_hematopoietic_system1.23360700
54MP0005397_hematopoietic_system_phenotyp1.23360700
55MP0003724_increased_susceptibility_to1.22735692
56MP0003195_calcinosis1.22241792
57MP0005257_abnormal_intraocular_pressure1.21355482
58MP0000685_abnormal_immune_system1.19894662
59MP0005666_abnormal_adipose_tissue1.14938734
60MP0003656_abnormal_erythrocyte_physiolo1.12226950
61MP0005166_decreased_susceptibility_to1.11884880
62MP0008004_abnormal_stomach_pH1.08520202
63MP0001819_abnormal_immune_cell1.07423012
64MP0002420_abnormal_adaptive_immunity1.06942671
65MP0010234_abnormal_vibrissa_follicle1.04000431
66MP0003690_abnormal_glial_cell1.00957898
67MP0008260_abnormal_autophagy0.99532992
68MP0004808_abnormal_hematopoietic_stem0.96250868
69MP0003091_abnormal_cell_migration0.95840119
70MP0006054_spinal_hemorrhage0.95230505
71MP0002332_abnormal_exercise_endurance0.94915736
72MP0001849_ear_inflammation0.93213841
73MP0000609_abnormal_liver_physiology0.90431595
74MP0005365_abnormal_bile_salt0.90048008
75MP0004233_abnormal_muscle_weight0.89613459
76MP0000716_abnormal_immune_system0.87725682
77MP0000678_abnormal_parathyroid_gland0.87092318
78MP0010352_gastrointestinal_tract_polyps0.85248407
79MP0004858_abnormal_nervous_system0.81249399
80MP0000920_abnormal_myelination0.80629787
81MP0001873_stomach_inflammation0.80243510
82MP0005647_abnormal_sex_gland0.79932597
83MP0001216_abnormal_epidermal_layer0.79857429
84MP0003693_abnormal_embryo_hatching0.79746583
85MP0002398_abnormal_bone_marrow0.77969213
86MP0005375_adipose_tissue_phenotype0.77264181
87MP0002429_abnormal_blood_cell0.77120159
88MP0003634_abnormal_glial_cell0.76123634
89MP0005023_abnormal_wound_healing0.74627478
90MP0003111_abnormal_nucleus_morphology0.74611735
91MP0000490_abnormal_crypts_of0.73837229
92MP0001915_intracranial_hemorrhage0.72017011
93MP0001727_abnormal_embryo_implantation0.71674198
94MP0008874_decreased_physiological_sensi0.71259598
95MP0005165_increased_susceptibility_to0.70872849
96MP0005464_abnormal_platelet_physiology0.68336989
97MP0003763_abnormal_thymus_physiology0.67743064
98MP0009763_increased_sensitivity_to0.65939167
99MP0002722_abnormal_immune_system0.59837124
100MP0005390_skeleton_phenotype0.58051645

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.92501891
2Abnormality of liposaccharide metabolism (HP:0010968)5.92501891
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.92501891
4Systemic lupus erythematosus (HP:0002725)4.32298250
5Vacuolated lymphocytes (HP:0001922)4.22855405
6Nuclear cataract (HP:0100018)4.06376349
7Deep venous thrombosis (HP:0002625)3.93221577
8Loss of speech (HP:0002371)3.90349317
9Increased cerebral lipofuscin (HP:0011813)3.88875953
10Dysostosis multiplex (HP:0000943)3.86173848
11Disinhibition (HP:0000734)3.84063378
12Neurofibrillary tangles (HP:0002185)3.61847046
13Glomerulonephritis (HP:0000099)3.35970952
14Axonal loss (HP:0003447)3.17260088
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.16435219
16Abnormality of macrophages (HP:0004311)3.13732905
17Cerebral inclusion bodies (HP:0100314)3.10228029
18Apathy (HP:0000741)3.06657463
19Mutism (HP:0002300)2.97798477
20Metaphyseal irregularity (HP:0003025)2.93503772
21Diminished motivation (HP:0000745)2.87460920
22Retrobulbar optic neuritis (HP:0100654)2.82845139
23Optic neuritis (HP:0100653)2.82845139
24Increased serum ferritin (HP:0003281)2.82372206
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82002808
26Abnormality of polysaccharide metabolism (HP:0011012)2.82002808
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82002808
28Neuronal loss in central nervous system (HP:0002529)2.77890821
29Orchitis (HP:0100796)2.77762202
30Mucopolysacchariduria (HP:0008155)2.74754572
31Urinary glycosaminoglycan excretion (HP:0003541)2.74754572
32Complement deficiency (HP:0004431)2.70624363
33Thin bony cortex (HP:0002753)2.69152056
34Purpura (HP:0000979)2.63086348
35Autoimmune thrombocytopenia (HP:0001973)2.61634916
36Personality changes (HP:0000751)2.61335376
37Upper motor neuron abnormality (HP:0002127)2.50576475
38Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48640248
39Hyperparathyroidism (HP:0000843)2.45832928
40Abnormality of the lumbar spine (HP:0100712)2.44137556
41Progressive external ophthalmoplegia (HP:0000590)2.43927928
42Mediastinal lymphadenopathy (HP:0100721)2.42249844
43Myocardial infarction (HP:0001658)2.37599089
44Achilles tendon contracture (HP:0001771)2.30372872
45Abnormality of complement system (HP:0005339)2.28165085
46Recurrent bacterial skin infections (HP:0005406)2.27795213
47Abnormality of the Achilles tendon (HP:0005109)2.25151321
48Hyperacusis (HP:0010780)2.24337145
49Multiple enchondromatosis (HP:0005701)2.22200734
50Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19771739
51Dysphonia (HP:0001618)2.11705956
52Vertebral compression fractures (HP:0002953)2.10205653
53Ragged-red muscle fibers (HP:0003200)2.08537003
54Bone pain (HP:0002653)2.08380482
55Segmental peripheral demyelination/remyelination (HP:0003481)2.04531214
56Gangrene (HP:0100758)2.04320919
57Thoracic kyphosis (HP:0002942)2.03810038
58Dementia (HP:0000726)2.03676451
59Hemorrhage of the eye (HP:0011885)2.03066692
60Flat occiput (HP:0005469)2.02772651
61Abnormality of the thoracic spine (HP:0100711)2.02618962
62Delayed epiphyseal ossification (HP:0002663)2.02487256
63Progressive neurologic deterioration (HP:0002344)2.00921739
64Myositis (HP:0100614)2.00162425
65Prolonged neonatal jaundice (HP:0006579)1.99704906
66Pathologic fracture (HP:0002756)1.98194442
67Interstitial pulmonary disease (HP:0006530)1.98164703
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97510239
69Nausea (HP:0002018)1.97245232
70Abnormal trabecular bone morphology (HP:0100671)1.92438530
71Agnosia (HP:0010524)1.91369872
72Eczematoid dermatitis (HP:0000976)1.88755252
73Recurrent abscess formation (HP:0002722)1.87186628
74Supranuclear gaze palsy (HP:0000605)1.86923031
75Keratoconjunctivitis sicca (HP:0001097)1.86094489
76Inappropriate behavior (HP:0000719)1.85750137
77Hypercholesterolemia (HP:0003124)1.85662828
78Insomnia (HP:0100785)1.85464929
79Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84883779
80Amyloidosis (HP:0011034)1.84684948
81Aplasia/Hypoplasia of the sacrum (HP:0008517)1.81798008
82Zonular cataract (HP:0010920)1.79639696
83Increased IgM level (HP:0003496)1.75749127
84Hypertensive crisis (HP:0100735)1.75618254
85Xanthomatosis (HP:0000991)1.75479048
86Abnormality of iron homeostasis (HP:0011031)1.75388587
87Hepatosplenomegaly (HP:0001433)1.75199780
88Asymmetry of the thorax (HP:0001555)1.75169816
89Widely patent fontanelles and sutures (HP:0004492)1.73963723
90Progressive muscle weakness (HP:0003323)1.73766859
91Generalized aminoaciduria (HP:0002909)1.73190466
92Peripheral demyelination (HP:0011096)1.72798558
93Cupped ribs (HP:0000887)1.71728242
94Recurrent viral infections (HP:0004429)1.67426769
95Cholecystitis (HP:0001082)1.67142702
96Abnormal gallbladder physiology (HP:0012438)1.67142702
97Stomatitis (HP:0010280)1.63723289
98Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.61648520
99Parakeratosis (HP:0001036)1.59213777
100Recurrent gram-negative bacterial infections (HP:0005420)1.58593270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.94479560
2NME25.47632138
3TAOK23.41912170
4ICK2.95116700
5PRPF4B2.71486350
6MAP3K142.66707053
7TRIB32.49401633
8DDR22.40462156
9RIPK12.38320538
10PIM22.34830432
11MAP3K112.28483319
12SMG12.14251205
13TAOK12.03836362
14FGFR41.94260446
15CDK121.90351674
16TYRO31.77394563
17LATS21.77058517
18MAP3K31.75439741
19MATK1.69054275
20TBK11.62507202
21SIK11.61898726
22GRK71.56762206
23EEF2K1.49270712
24ERN11.48603664
25MAP2K31.44586925
26IKBKB1.27410569
27MOS1.26806933
28FGR1.25911888
29ARAF1.25848079
30PDGFRA1.17819879
31IRAK41.17217229
32MAP3K11.15904235
33IRAK21.15553523
34MAP3K91.09024130
35CHUK1.06792921
36CDC42BPA1.05156019
37MAP3K131.01526652
38RIPK41.00012377
39ABL20.87277233
40MAP4K10.84018374
41TYK20.83579198
42SIK20.82285644
43CDK40.79370870
44IKBKE0.76843743
45CSK0.74499027
46TESK20.74254670
47MAP3K50.73581337
48PKN20.71003752
49MAP3K80.70148769
50BRAF0.68901599
51MAPK110.68184954
52CAMK1D0.68168813
53CDK60.68083132
54FGFR30.65070042
55JAK30.61499260
56PDPK10.61069823
57PAK40.60702164
58ALK0.60544399
59EPHA20.55197881
60BMPR20.55003008
61TGFBR20.54616991
62KSR20.51713360
63CLK10.50412139
64CDK150.49214778
65DYRK30.48024924
66BLK0.47255342
67CDK70.46561727
68BMX0.46376692
69CDK11A0.46303300
70TESK10.45307534
71MTOR0.43880464
72MAP2K60.43486846
73CDK140.43067451
74CDK180.42333703
75PDK10.41183548
76SIK30.40362166
77PBK0.38767799
78MST1R0.38448431
79IRAK10.37125323
80MAP3K100.36422896
81STK100.36338300
82PDK20.36279628
83HIPK20.34988640
84RPS6KC10.32889648
85RPS6KL10.32889648
86PIM10.31738539
87RPS6KA10.30808266
88DAPK10.30525624
89DYRK1B0.30454874
90MAPK40.28289961
91BUB10.27101183
92CSF1R0.26554597
93DAPK30.26537288
94JAK20.25258693
95AURKA0.23832976
96CHEK20.23747116
97RPS6KB20.22840510
98CAMKK10.22017826
99SCYL20.21687572
100MAPKAPK20.21145932

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.85664094
2Toll-like receptor signaling pathway_Homo sapiens_hsa046202.92125322
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.69814792
4TNF signaling pathway_Homo sapiens_hsa046682.45598178
5Lysosome_Homo sapiens_hsa041422.38854559
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21415578
7Prion diseases_Homo sapiens_hsa050202.17091123
8Osteoclast differentiation_Homo sapiens_hsa043802.13569162
9Bladder cancer_Homo sapiens_hsa052192.08368271
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.02035134
11Rheumatoid arthritis_Homo sapiens_hsa053231.95579925
12Pertussis_Homo sapiens_hsa051331.94317743
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.92362442
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90629363
15Legionellosis_Homo sapiens_hsa051341.86880244
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76597756
17African trypanosomiasis_Homo sapiens_hsa051431.74036821
18Malaria_Homo sapiens_hsa051441.73862573
19Leishmaniasis_Homo sapiens_hsa051401.70625757
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.65960962
21Salmonella infection_Homo sapiens_hsa051321.62424491
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57391205
23Staphylococcus aureus infection_Homo sapiens_hsa051501.56088293
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55362707
25Influenza A_Homo sapiens_hsa051641.52848271
26Tuberculosis_Homo sapiens_hsa051521.49479556
27Allograft rejection_Homo sapiens_hsa053301.42596656
28Toxoplasmosis_Homo sapiens_hsa051451.29109456
29Asthma_Homo sapiens_hsa053101.27995754
30Hepatitis B_Homo sapiens_hsa051611.27959260
31Herpes simplex infection_Homo sapiens_hsa051681.27694824
32Complement and coagulation cascades_Homo sapiens_hsa046101.27085187
33Acute myeloid leukemia_Homo sapiens_hsa052211.27014488
34Hepatitis C_Homo sapiens_hsa051601.24740679
35VEGF signaling pathway_Homo sapiens_hsa043701.22968591
36Apoptosis_Homo sapiens_hsa042101.20220995
37Adipocytokine signaling pathway_Homo sapiens_hsa049201.16110578
38B cell receptor signaling pathway_Homo sapiens_hsa046621.15530494
39Measles_Homo sapiens_hsa051621.14595015
40Chronic myeloid leukemia_Homo sapiens_hsa052201.13210339
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13044540
42Fructose and mannose metabolism_Homo sapiens_hsa000511.11570486
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06026458
44Sphingolipid metabolism_Homo sapiens_hsa006001.03713531
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03640894
46Shigellosis_Homo sapiens_hsa051311.03111202
47Epstein-Barr virus infection_Homo sapiens_hsa051691.02822229
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01078094
49Galactose metabolism_Homo sapiens_hsa000520.96033637
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94419813
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.94240104
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93810907
53Prolactin signaling pathway_Homo sapiens_hsa049170.93509869
54Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89696278
55Vibrio cholerae infection_Homo sapiens_hsa051100.86805214
56Vitamin B6 metabolism_Homo sapiens_hsa007500.86032776
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.84872197
58T cell receptor signaling pathway_Homo sapiens_hsa046600.83741510
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.81274308
60Graft-versus-host disease_Homo sapiens_hsa053320.79301504
61Fatty acid biosynthesis_Homo sapiens_hsa000610.78506374
62Steroid biosynthesis_Homo sapiens_hsa001000.77865001
63Autoimmune thyroid disease_Homo sapiens_hsa053200.76093806
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.73694379
65HTLV-I infection_Homo sapiens_hsa051660.73281478
66Pancreatic cancer_Homo sapiens_hsa052120.72670206
67Sulfur relay system_Homo sapiens_hsa041220.71459267
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70512400
69Chemokine signaling pathway_Homo sapiens_hsa040620.68741922
70Amoebiasis_Homo sapiens_hsa051460.68696525
71Hematopoietic cell lineage_Homo sapiens_hsa046400.68340092
72Pentose phosphate pathway_Homo sapiens_hsa000300.68147169
73Non-small cell lung cancer_Homo sapiens_hsa052230.68140733
74Viral carcinogenesis_Homo sapiens_hsa052030.67925531
75Antigen processing and presentation_Homo sapiens_hsa046120.67321003
76HIF-1 signaling pathway_Homo sapiens_hsa040660.65461600
77Notch signaling pathway_Homo sapiens_hsa043300.64253100
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.62158617
79Type I diabetes mellitus_Homo sapiens_hsa049400.58069162
80mTOR signaling pathway_Homo sapiens_hsa041500.55557083
81Small cell lung cancer_Homo sapiens_hsa052220.55222307
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52619044
83Type II diabetes mellitus_Homo sapiens_hsa049300.50147885
84Phagosome_Homo sapiens_hsa041450.49564527
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49261671
86ErbB signaling pathway_Homo sapiens_hsa040120.48813372
87MicroRNAs in cancer_Homo sapiens_hsa052060.47181076
88Biosynthesis of amino acids_Homo sapiens_hsa012300.47032314
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46011722
90Viral myocarditis_Homo sapiens_hsa054160.43998977
91PPAR signaling pathway_Homo sapiens_hsa033200.43945418
92Glioma_Homo sapiens_hsa052140.43351946
93Sulfur metabolism_Homo sapiens_hsa009200.40962468
94Insulin signaling pathway_Homo sapiens_hsa049100.40863400
95Insulin resistance_Homo sapiens_hsa049310.40361195
96Renal cell carcinoma_Homo sapiens_hsa052110.39777304
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39737224
98DNA replication_Homo sapiens_hsa030300.39497354
99Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35412604
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34801890

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