ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	9.09516578
2	acrosome reaction (GO:0007340)	7.57659093
3	spermatid development (GO:0007286)	7.17211911
4	ventricular system development (GO:0021591)	6.85572370
5	regulation of cilium movement (GO:0003352)	6.81489662
6	fusion of sperm to egg plasma membrane (GO:0007342)	6.56861232
7	microtubule depolymerization (GO:0007019)	6.46851179
8	left/right pattern formation (GO:0060972)	6.46639441
9	sperm capacitation (GO:0048240)	6.21168268
10	multicellular organism reproduction (GO:0032504)	6.12520452
11	centriole assembly (GO:0098534)	6.04116592
12	axoneme assembly (GO:0035082)	5.97381203
13	plasma membrane fusion (GO:0045026)	5.22514406
14	intraciliary transport (GO:0042073)	5.21343336
15	regulation of phosphoprotein phosphatase activity (GO:0043666)	5.07610682
16	binding of sperm to zona pellucida (GO:0007339)	5.05394972
17	sperm-egg recognition (GO:0035036)	4.98290551
18	microtubule polymerization or depolymerization (GO:0031109)	4.95781190
19	reproduction (GO:0000003)	4.90650813
20	protein polyglutamylation (GO:0018095)	4.83711901
21	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.81013590
22	single fertilization (GO:0007338)	4.74901243
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.72137601
24	negative regulation of inclusion body assembly (GO:0090084)	4.68868032
25	cilium organization (GO:0044782)	4.67399544
26	cilium assembly (GO:0042384)	4.60116086
27	spermatid nucleus differentiation (GO:0007289)	4.59080293
28	positive regulation of catecholamine secretion (GO:0033605)	4.55233484
29	left/right axis specification (GO:0070986)	4.46393501
30	centriole replication (GO:0007099)	4.44735131
31	microtubule severing (GO:0051013)	4.44387184
32	cell-cell recognition (GO:0009988)	4.36590369
33	phosphatidylethanolamine metabolic process (GO:0046337)	4.18887137
34	regulation of autophagic vacuole assembly (GO:2000785)	4.17830258
35	regulation of microtubule-based movement (GO:0060632)	4.08292092
36	organic cation transport (GO:0015695)	3.97246170
37	germ cell development (GO:0007281)	3.91418704
38	microtubule bundle formation (GO:0001578)	3.83894154
39	calcium ion-dependent exocytosis (GO:0017156)	3.82435653
40	spermatogenesis (GO:0007283)	3.77240892
41	male gamete generation (GO:0048232)	3.75113916
42	microtubule-based movement (GO:0007018)	3.73922138
43	relaxation of smooth muscle (GO:0044557)	3.66000446
44	primary alcohol catabolic process (GO:0034310)	3.63150762
45	regulation of interleukin-13 production (GO:0032656)	3.62864298
46	nucleoside diphosphate phosphorylation (GO:0006165)	3.59883593
47	cellular component assembly involved in morphogenesis (GO:0010927)	3.58107545
48	coenzyme catabolic process (GO:0009109)	3.57688032
49	fertilization (GO:0009566)	3.57328795
50	protein-DNA complex disassembly (GO:0032986)	3.53675860
51	nucleosome disassembly (GO:0006337)	3.53675860
52	male meiosis (GO:0007140)	3.49719927
53	mitochondrion degradation (GO:0000422)	3.48445766
54	regulation of vacuole organization (GO:0044088)	3.46190352
55	ethanol metabolic process (GO:0006067)	3.45295899
56	gamete generation (GO:0007276)	3.43636897
57	male sex determination (GO:0030238)	3.41638907
58	response to acidic pH (GO:0010447)	3.41406091
59	polyamine biosynthetic process (GO:0006596)	3.39434201
60	chromosome condensation (GO:0030261)	3.36001665
61	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.35103216
62	protein localization to cilium (GO:0061512)	3.32752606
63	rRNA methylation (GO:0031167)	3.26269347
64	activation of protein kinase B activity (GO:0032148)	3.19359625
65	potassium ion export (GO:0071435)	3.12933770
66	DNA packaging (GO:0006323)	3.09884890
67	regulation of inclusion body assembly (GO:0090083)	3.01177743
68	glutathione derivative biosynthetic process (GO:1901687)	2.98807724
69	glutathione derivative metabolic process (GO:1901685)	2.98807724
70	cell projection assembly (GO:0030031)	2.98393407
71	rRNA modification (GO:0000154)	2.96087545
72	regulation of cilium assembly (GO:1902017)	2.92937468
73	pattern specification involved in kidney development (GO:0061004)	2.89529154
74	protein targeting to Golgi (GO:0000042)	2.89491147
75	cilium morphogenesis (GO:0060271)	2.87843405
76	androgen biosynthetic process (GO:0006702)	2.84576501
77	cranial nerve morphogenesis (GO:0021602)	2.80804753
78	multicellular organismal reproductive process (GO:0048609)	2.78144188
79	tongue development (GO:0043586)	2.77695321
80	seminiferous tubule development (GO:0072520)	2.77604143
81	regulation of interleukin-5 production (GO:0032674)	2.73718497
82	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.73491378
83	thyroid gland development (GO:0030878)	2.72599923
84	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.69907511
85	establishment of protein localization to Golgi (GO:0072600)	2.69615160
86	oligosaccharide biosynthetic process (GO:0009312)	2.64314921
87	microtubule-based process (GO:0007017)	2.62292585
88	regulation of dopamine secretion (GO:0014059)	2.62200068
89	regulation of oxidative phosphorylation (GO:0002082)	2.60865664
90	protein polymerization (GO:0051258)	2.57954829
91	Leydig cell differentiation (GO:0033327)	2.57014908
92	lung epithelium development (GO:0060428)	2.56878783
93	protein localization to Golgi apparatus (GO:0034067)	2.55213172
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.54915643
95	axonemal dynein complex assembly (GO:0070286)	16.8648700
96	motile cilium assembly (GO:0044458)	13.0760559
97	cilium or flagellum-dependent cell motility (GO:0001539)	12.5359730
98	cilium movement (GO:0003341)	11.6592808
99	epithelial cilium movement (GO:0003351)	11.5794859
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	10.7818559

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.14052525
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.60971126
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.18547415
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.26334218
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.79441378
6	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.60770045
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.32087557
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.23433815
9	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.23403227
10	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.21499634
11	* SMC4_20622854_ChIP-Seq_HELA_Human	2.21221815
12	* CTCF_27219007_Chip-Seq_Bcells_Human	2.17378913
13	P68_20966046_ChIP-Seq_HELA_Human	2.07599148
14	LXR_22292898_ChIP-Seq_THP-1_Human	1.94909127
15	STAT1_20625510_ChIP-Seq_HELA_Human	1.91267365
16	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.90952129
17	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.89969889
18	NANOG_20526341_ChIP-Seq_ESCs_Human	1.84945142
19	DROSHA_22980978_ChIP-Seq_HELA_Human	1.83835136
20	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.82238641
21	BCL6_27268052_Chip-Seq_Bcells_Human	1.79966604
22	ERA_21632823_ChIP-Seq_H3396_Human	1.79252199
23	* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.76190919
24	* PHF8_20622854_ChIP-Seq_HELA_Human	1.72143277
25	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.71022600
26	P300_27268052_Chip-Seq_Bcells_Human	1.70013645
27	TP63_22573176_ChIP-Seq_HFKS_Human	1.68222227
28	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.67736113
29	* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.67266994
30	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.65319464
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.62398729
32	* E2F1_20622854_ChIP-Seq_HELA_Human	1.60672548
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57748620
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.57748620
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57384905
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57384905
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.55273350
38	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.51170820
39	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.50135102
40	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.50006838
41	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.49834962
42	* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.49304141
43	* RAC3_21632823_ChIP-Seq_H3396_Human	1.48855783
44	* BCOR_27268052_Chip-Seq_Bcells_Human	1.48353647
45	OCT4_20526341_ChIP-Seq_ESCs_Human	1.47287987
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.42125313
47	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.41744741
48	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.41390779
49	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.40732937
50	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.37897838
51	SPI1_20517297_ChIP-Seq_HL60_Human	1.37720466
52	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.34280673
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33107901
54	MYC_19829295_ChIP-Seq_ESCs_Human	1.32537893
55	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.28030316
56	ERG_20517297_ChIP-Seq_VCAP_Human	1.25076423
57	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.21418549
58	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.20537551
59	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18992919
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18659733
61	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15688982
62	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15212255
63	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13700152
64	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11936427
65	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.10565461
66	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.10308342
67	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09520396
68	TBL1_22424771_ChIP-Seq_293T_Human	1.09242688
69	IGF1R_20145208_ChIP-Seq_DFB_Human	1.07127490
70	FUS_26573619_Chip-Seq_HEK293_Human	1.07038202
71	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.06663090
72	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.06608921
73	* OCT4_19829295_ChIP-Seq_ESCs_Human	1.06147332
74	* CTCF_21964334_Chip-Seq_Bcells_Human	1.06053126
75	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.05944162
76	ER_23166858_ChIP-Seq_MCF-7_Human	1.04410936
77	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.01937877
78	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.01609149
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01079159
80	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.00934438
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97644548
82	CEBPB_22108803_ChIP-Seq_LS180_Human	0.97590517
83	SA1_27219007_Chip-Seq_Bcells_Human	0.97316793
84	TP53_18474530_ChIP-ChIP_U2OS_Human	0.96415185
85	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.96228019
86	PHF8_20622853_ChIP-Seq_HELA_Human	0.96180008
87	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.95513776
88	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.94022268
89	* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93418949
90	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90807083
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90672331
92	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.90375213
93	KLF4_19829295_ChIP-Seq_ESCs_Human	0.89171721
94	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.89063681
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86590072
96	NFYB_21822215_ChIP-Seq_K562_Human	0.86132162
97	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.86099341
98	CREB1_26743006_Chip-Seq_LNCaP_Human	0.85825205
99	* CTCF_21964334_ChIP-Seq_BJAB-B_Human	0.85801751
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.85689004

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.24331363
2	MP0002132_abnormal_respiratory_system	5.11110208
3	MP0000566_synostosis	3.70193387
4	MP0008004_abnormal_stomach_pH	3.49171070
5	MP0003698_abnormal_male_reproductive	3.35252585
6	MP0003315_abnormal_perineum_morphology	3.18430544
7	MP0002653_abnormal_ependyma_morphology	3.14849723
8	MP0001929_abnormal_gametogenesis	2.90792789
9	MP0001984_abnormal_olfaction	2.85253050
10	MP0002160_abnormal_reproductive_system	2.65258714
11	MP0003878_abnormal_ear_physiology	2.60960713
12	MP0005377_hearing/vestibular/ear_phenot	2.60960713
13	MP0000678_abnormal_parathyroid_gland	2.52225715
14	MP0002249_abnormal_larynx_morphology	2.30237444
15	MP0003136_yellow_coat_color	2.17922230
16	MP0008875_abnormal_xenobiotic_pharmacok	2.14667413
17	MP0005646_abnormal_pituitary_gland	1.98414774
18	MP0002822_catalepsy	1.97246232
19	MP0005499_abnormal_olfactory_system	1.93314247
20	MP0005394_taste/olfaction_phenotype	1.93314247
21	MP0002161_abnormal_fertility/fecundity	1.82808169
22	MP0008789_abnormal_olfactory_epithelium	1.74542895
23	MP0002277_abnormal_respiratory_mucosa	1.74348874
24	MP0008995_early_reproductive_senescence	1.66376629
25	MP0002282_abnormal_trachea_morphology	1.63261914
26	MP0004133_heterotaxia	1.58256807
27	MP0001905_abnormal_dopamine_level	1.55339426
28	MP0003806_abnormal_nucleotide_metabolis	1.53801997
29	MP0005058_abnormal_lysosome_morphology	1.50071326
30	MP0002210_abnormal_sex_determination	1.47934807
31	MP0000681_abnormal_thyroid_gland	1.44086995
32	MP0001485_abnormal_pinna_reflex	1.40973372
33	MP0001145_abnormal_male_reproductive	1.38008241
34	MP0001849_ear_inflammation	1.31514574
35	MP0001664_abnormal_digestion	1.30034326
36	MP0005623_abnormal_meninges_morphology	1.29200725
37	MP0000653_abnormal_sex_gland	1.28609105
38	MP0002127_abnormal_cardiovascular_syste	1.24407930
39	MP0005389_reproductive_system_phenotype	1.23592421
40	MP0010386_abnormal_urinary_bladder	1.22894255
41	MP0003879_abnormal_hair_cell	1.21748490
42	MP0000537_abnormal_urethra_morphology	1.20225576
43	MP0006036_abnormal_mitochondrial_physio	1.17202282
44	MP0000049_abnormal_middle_ear	1.15502039
45	MP0004859_abnormal_synaptic_plasticity	1.06433311
46	MP0009379_abnormal_foot_pigmentation	1.05037861
47	MP0001765_abnormal_ion_homeostasis	1.01622934
48	MP0005248_abnormal_Harderian_gland	1.01461510
49	MP0000026_abnormal_inner_ear	1.00497938
50	MP0005670_abnormal_white_adipose	1.00192424
51	MP0001963_abnormal_hearing_physiology	0.90960450
52	MP0003718_maternal_effect	0.88163327
53	MP0006072_abnormal_retinal_apoptosis	0.87215362
54	MP0009046_muscle_twitch	0.87057264
55	MP0001188_hyperpigmentation	0.83579743
56	MP0004019_abnormal_vitamin_homeostasis	0.80158652
57	MP0004085_abnormal_heartbeat	0.79924834
58	MP0000465_gastrointestinal_hemorrhage	0.79008723
59	MP0002272_abnormal_nervous_system	0.77563697
60	MP0001348_abnormal_lacrimal_gland	0.77482290
61	MP0005423_abnormal_somatic_nervous	0.77474676
62	MP0001270_distended_abdomen	0.76341428
63	MP0003936_abnormal_reproductive_system	0.75977120
64	MP0009780_abnormal_chondrocyte_physiolo	0.74687142
65	MP0002233_abnormal_nose_morphology	0.72606302
66	MP0005253_abnormal_eye_physiology	0.72342259
67	MP0005397_hematopoietic_system_phenotyp	0.71230023
68	MP0001545_abnormal_hematopoietic_system	0.71230023
69	MP0001486_abnormal_startle_reflex	0.69396486
70	MP0005395_other_phenotype	0.68677720
71	MP0003828_pulmonary_edema	0.67732312
72	MP0005647_abnormal_sex_gland	0.66284444
73	MP0005451_abnormal_body_composition	0.62566197
74	MP0000631_abnormal_neuroendocrine_gland	0.62478861
75	MP0000955_abnormal_spinal_cord	0.60372156
76	MP0009697_abnormal_copulation	0.59480760
77	MP0005503_abnormal_tendon_morphology	0.59137927
78	MP0001529_abnormal_vocalization	0.58677966
79	MP0005551_abnormal_eye_electrophysiolog	0.58187219
80	MP0003632_abnormal_nervous_system	0.58029698
81	MP0000343_altered_response_to	0.56980879
82	MP0009278_abnormal_bone_marrow	0.56624026
83	MP0010368_abnormal_lymphatic_system	0.55859187
84	MP0002837_dystrophic_cardiac_calcinosis	0.55030572
85	MP0002168_other_aberrant_phenotype	0.54173343
86	MP0005595_abnormal_vascular_smooth	0.53887472
87	MP0002572_abnormal_emotion/affect_behav	0.53874049
88	MP0003045_fibrosis	0.51674759
89	MP0004084_abnormal_cardiac_muscle	0.51189481
90	MP0004043_abnormal_pH_regulation	0.51061317
91	MP0002557_abnormal_social/conspecific_i	0.51050546
92	MP0002229_neurodegeneration	0.50818568
93	MP0001970_abnormal_pain_threshold	0.50444086
94	MP0001440_abnormal_grooming_behavior	0.50066934
95	MP0009745_abnormal_behavioral_response	0.49946035
96	MP0002735_abnormal_chemical_nociception	0.49400420
97	MP0003631_nervous_system_phenotype	0.47024179
98	MP0000230_abnormal_systemic_arterial	0.45464564
99	MP0005391_vision/eye_phenotype	0.44928287
100	MP0002752_abnormal_somatic_nervous	0.44644708

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	8.11822329
2	Nasal polyposis (HP:0100582)	6.25675393
3	Chronic bronchitis (HP:0004469)	6.17409034
4	Bronchiectasis (HP:0002110)	6.04192223
5	Infertility (HP:0000789)	5.39698650
6	Abnormality of the nasal mucosa (HP:0000433)	5.19565684
7	Male infertility (HP:0003251)	4.03241295
8	Chronic sinusitis (HP:0011109)	3.94608134
9	Occipital encephalocele (HP:0002085)	3.47121225
10	Tubulointerstitial nephritis (HP:0001970)	3.26345350
11	Recurrent sinusitis (HP:0011108)	3.18669699
12	Bronchitis (HP:0012387)	3.12787279
13	Chronic hepatic failure (HP:0100626)	3.08797426
14	True hermaphroditism (HP:0010459)	3.07460739
15	Pancreatic fibrosis (HP:0100732)	2.94974285
16	Male pseudohermaphroditism (HP:0000037)	2.90687637
17	Resting tremor (HP:0002322)	2.80108471
18	Recurrent otitis media (HP:0000403)	2.77683141
19	Nephronophthisis (HP:0000090)	2.74904116
20	Atelectasis (HP:0100750)	2.74782366
21	Abnormal sex determination (HP:0012244)	2.57531714
22	Sex reversal (HP:0012245)	2.57531714
23	Cystic liver disease (HP:0006706)	2.55380567
24	Pancreatic cysts (HP:0001737)	2.39095298
25	Bell-shaped thorax (HP:0001591)	2.33461552
26	Postural instability (HP:0002172)	2.32976818
27	Chronic otitis media (HP:0000389)	2.18020015
28	Abnormality of the renal medulla (HP:0100957)	2.11168209
29	Hypoplasia of the uterus (HP:0000013)	2.05443119
30	Abnormality of midbrain morphology (HP:0002418)	2.05433283
31	Molar tooth sign on MRI (HP:0002419)	2.05433283
32	Anencephaly (HP:0002323)	2.02906852
33	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.02668907
34	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	10.9963833
35	Absent/shortened dynein arms (HP:0200106)	10.3419834
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.3419834
37	Abnormal respiratory motile cilium physiology (HP:0012261)	10.2986549
38	Abnormal respiratory epithelium morphology (HP:0012253)	10.1572838
39	Abnormal respiratory motile cilium morphology (HP:0005938)	10.1572838
40	Abnormal ciliary motility (HP:0012262)	10.1330079
41	Abnormal rod and cone electroretinograms (HP:0008323)	1.98159826
42	Median cleft lip (HP:0000161)	1.96640781
43	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93793038
44	Abnormality of the frontal sinuses (HP:0002687)	1.91316555
45	Colitis (HP:0002583)	1.87800574
46	Congenital hepatic fibrosis (HP:0002612)	1.86382860
47	Postaxial foot polydactyly (HP:0001830)	1.85084092
48	Sclerocornea (HP:0000647)	1.82653250
49	Renal dysplasia (HP:0000110)	1.81726071
50	Gonadal dysgenesis (HP:0000133)	1.79100233
51	Abnormality of macular pigmentation (HP:0008002)	1.76586519
52	Severe visual impairment (HP:0001141)	1.76467073
53	Self-mutilation (HP:0000742)	1.70391303
54	Abnormality of the columella (HP:0009929)	1.69506974
55	Bony spicule pigmentary retinopathy (HP:0007737)	1.61675157
56	Hyperactive renin-angiotensin system (HP:0000841)	1.57570986
57	Tubulointerstitial abnormality (HP:0001969)	1.53520879
58	Thoracic kyphosis (HP:0002942)	1.52312745
59	Aplasia/hypoplasia of the uterus (HP:0008684)	1.52013668
60	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.50141627
61	Hyperkalemia (HP:0002153)	1.46427162
62	Renal salt wasting (HP:0000127)	1.45854714
63	Cone-rod dystrophy (HP:0000548)	1.45736922
64	Decreased central vision (HP:0007663)	1.44735158
65	Azoospermia (HP:0000027)	1.44641858
66	Polydipsia (HP:0001959)	1.44389681
67	Abnormal drinking behavior (HP:0030082)	1.44389681
68	Stage 5 chronic kidney disease (HP:0003774)	1.43732315
69	Asplenia (HP:0001746)	1.42315066
70	Reduced antithrombin III activity (HP:0001976)	1.40114303
71	Ventricular fibrillation (HP:0001663)	1.39250361
72	Short nail (HP:0001799)	1.37668140
73	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.34625418
74	Myokymia (HP:0002411)	1.33549554
75	Type II lissencephaly (HP:0007260)	1.32649336
76	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.32045395
77	Nephropathy (HP:0000112)	1.30308331
78	Cerebellar dysplasia (HP:0007033)	1.29688422
79	Abnormality of permanent molar morphology (HP:0011071)	1.28982282
80	Abnormality of the dental root (HP:0006486)	1.28982282
81	Taurodontia (HP:0000679)	1.28982282
82	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.28739861
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.27042245
84	Flattened epiphyses (HP:0003071)	1.25700163
85	Epiphyseal dysplasia (HP:0002656)	1.21259506
86	Retinal dysplasia (HP:0007973)	1.19802462
87	Postaxial hand polydactyly (HP:0001162)	1.19557031
88	Tubular atrophy (HP:0000092)	1.17480645
89	Abnormality of renal excretion (HP:0011036)	1.16922634
90	Atonic seizures (HP:0010819)	1.16842360
91	Abnormality of molar morphology (HP:0011070)	1.16722062
92	Abnormality of molar (HP:0011077)	1.16722062
93	Abnormality of the dental pulp (HP:0006479)	1.16707812
94	Atrial fibrillation (HP:0005110)	1.13187558
95	Polyuria (HP:0000103)	1.11126207
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.10130214
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.10130214
98	Gastrointestinal inflammation (HP:0004386)	1.09676161
99	Short femoral neck (HP:0100864)	1.09338962
100	Primary atrial arrhythmia (HP:0001692)	1.08676877

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	8.00032410
2	MAPK15	6.65268273
3	MARK3	3.66318462
4	TLK1	3.34171005
5	PLK4	2.64609892
6	ZAK	2.47211328
7	MAPKAPK3	2.31717237
8	PNCK	2.19025276
9	STK38	2.15479505
10	MYLK	2.10825899
11	TESK1	1.98338222
12	NEK2	1.96836403
13	VRK2	1.74000167
14	PRKD3	1.59073009
15	INSRR	1.49125939
16	STK38L	1.42853410
17	MST1R	1.37819671
18	CDK8	1.37011423
19	RPS6KA5	1.35981303
20	MAP2K7	1.34687744
21	LATS2	1.30137271
22	SMG1	1.18748108
23	LATS1	1.14033145
24	MAP3K11	1.07054179
25	VRK1	1.06826615
26	CDK3	1.04083388
27	ARAF	1.02163547
28	EEF2K	0.97148971
29	CCNB1	0.96373912
30	DYRK3	0.93992357
31	PTK2B	0.93814629
32	BMPR1B	0.91679138
33	PRKCQ	0.90169468
34	NME1	0.85177991
35	PDPK1	0.84961297
36	SGK223	0.83781729
37	SGK494	0.83781729
38	RPS6KA2	0.82069904
39	GRK6	0.81576475
40	OBSCN	0.78749001
41	EPHA2	0.78686887
42	DYRK2	0.75883600
43	LMTK2	0.74721406
44	AURKA	0.73284762
45	DYRK1B	0.71851771
46	DAPK3	0.71630268
47	MAP4K2	0.69270709
48	MAP3K1	0.68761055
49	DDR2	0.68620177
50	PRKG2	0.66986614
51	CSNK1G3	0.66710104
52	PAK1	0.65368678
53	NME2	0.63627837
54	BRAF	0.61252837
55	STK16	0.61088972
56	BCKDK	0.61054274
57	CSNK1A1L	0.59262571
58	CSNK1G2	0.57280930
59	PDK1	0.56451825
60	TRIB3	0.54425613
61	PIM2	0.54001102
62	PLK2	0.53545992
63	UHMK1	0.53122400
64	MARK2	0.49418922
65	SIK2	0.48238000
66	ROCK1	0.47782975
67	CAMK1	0.47579678
68	CDK12	0.47254174
69	TBK1	0.46810393
70	BTK	0.43192783
71	CDC42BPA	0.41885890
72	MAP3K5	0.41590938
73	MAP2K2	0.39658978
74	TNK2	0.39512113
75	KIT	0.38401982
76	RPS6KA1	0.38324514
77	MINK1	0.37487805
78	PIK3CG	0.36811464
79	TAOK3	0.35711634
80	CAMK1G	0.34394689
81	PRKG1	0.34202018
82	MELK	0.33034457
83	MAPKAPK5	0.32647585
84	AKT2	0.32467434
85	TIE1	0.31838998
86	CDK7	0.29727906
87	MAP3K7	0.29265515
88	CSNK1G1	0.29250085
89	WNK1	0.28615890
90	MUSK	0.27942684
91	CSNK1A1	0.27203507
92	RPS6KC1	0.27096696
93	RPS6KL1	0.27096696
94	CDK14	0.26676802
95	CAMK2G	0.25565996
96	PKN1	0.23823448
97	GRK1	0.22859151
98	ILK	0.22298523
99	LRRK2	0.22064271
100	RPS6KA6	0.21329101

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine metabolism_Homo sapiens_hsa00360	3.83469533
2	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	3.41695388
3	Olfactory transduction_Homo sapiens_hsa04740	3.41195886
4	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.34781413
5	Chemical carcinogenesis_Homo sapiens_hsa05204	3.03622847
6	Gap junction_Homo sapiens_hsa04540	2.81035726
7	Tyrosine metabolism_Homo sapiens_hsa00350	2.69159672
8	Glutathione metabolism_Homo sapiens_hsa00480	2.56530781
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.50283928
10	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.49115952
11	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.46800452
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.27956704
13	Histidine metabolism_Homo sapiens_hsa00340	2.10365698
14	Butanoate metabolism_Homo sapiens_hsa00650	2.09149949
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.07141910
16	Huntingtons disease_Homo sapiens_hsa05016	2.03921258
17	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.98815652
18	beta-Alanine metabolism_Homo sapiens_hsa00410	1.94387132
19	Fatty acid degradation_Homo sapiens_hsa00071	1.86081493
20	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.80450354
21	Alcoholism_Homo sapiens_hsa05034	1.70162988
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.67363507
23	Phototransduction_Homo sapiens_hsa04744	1.59882671
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.57137007
25	Phagosome_Homo sapiens_hsa04145	1.48650412
26	Taste transduction_Homo sapiens_hsa04742	1.41237890
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28937609
28	Ribosome_Homo sapiens_hsa03010	1.25389695
29	Apoptosis_Homo sapiens_hsa04210	1.17940608
30	Propanoate metabolism_Homo sapiens_hsa00640	1.13977134
31	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07784148
32	Purine metabolism_Homo sapiens_hsa00230	1.00632056
33	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94467453
34	Retinol metabolism_Homo sapiens_hsa00830	0.94181825
35	Salivary secretion_Homo sapiens_hsa04970	0.93148221
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.88398711
37	Calcium signaling pathway_Homo sapiens_hsa04020	0.86197789
38	Circadian entrainment_Homo sapiens_hsa04713	0.86001002
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.84519668
40	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.84517816
41	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83880125
42	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.83400535
43	Gastric acid secretion_Homo sapiens_hsa04971	0.79876223
44	Peroxisome_Homo sapiens_hsa04146	0.75725363
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73238983
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67057235
47	Parkinsons disease_Homo sapiens_hsa05012	0.66880243
48	Renin secretion_Homo sapiens_hsa04924	0.66256000
49	PPAR signaling pathway_Homo sapiens_hsa03320	0.65969889
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64489645
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62907706
52	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60179023
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59177328
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59016660
55	Metabolic pathways_Homo sapiens_hsa01100	0.58768362
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57633057
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.57069307
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56816541
59	Arginine biosynthesis_Homo sapiens_hsa00220	0.56624170
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54425898
61	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54293336
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.54141362
63	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.53953486
64	Caffeine metabolism_Homo sapiens_hsa00232	0.53681174
65	Oxidative phosphorylation_Homo sapiens_hsa00190	0.51969336
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.48140272
67	Pyruvate metabolism_Homo sapiens_hsa00620	0.47828558
68	Basal cell carcinoma_Homo sapiens_hsa05217	0.46871688
69	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.45973932
70	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.45250354
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43428779
72	Pentose phosphate pathway_Homo sapiens_hsa00030	0.41799003
73	Cocaine addiction_Homo sapiens_hsa05030	0.41716055
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.41303787
75	Oocyte meiosis_Homo sapiens_hsa04114	0.40975873
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.40008419
77	Alzheimers disease_Homo sapiens_hsa05010	0.39657427
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.39310349
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37579091
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37426717
81	Base excision repair_Homo sapiens_hsa03410	0.37089369
82	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.35166640
83	Serotonergic synapse_Homo sapiens_hsa04726	0.34701882
84	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.33945888
85	GABAergic synapse_Homo sapiens_hsa04727	0.33843190
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.32125407
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.31466588
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30447550
89	Tight junction_Homo sapiens_hsa04530	0.29487835
90	Allograft rejection_Homo sapiens_hsa05330	0.28853145
91	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.27706575
92	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.27522555
93	Antigen processing and presentation_Homo sapiens_hsa04612	0.27240542
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27199307
95	Nicotine addiction_Homo sapiens_hsa05033	0.26267932
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.25944117
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.24467924
98	Morphine addiction_Homo sapiens_hsa05032	0.23714636
99	Melanoma_Homo sapiens_hsa05218	0.22664108
100	Melanogenesis_Homo sapiens_hsa04916	0.22648267

C17ORF97

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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