ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.68809070
2	chromosome condensation (GO:0030261)	9.58976413
3	DNA packaging (GO:0006323)	9.09283081
4	spermatid nucleus differentiation (GO:0007289)	8.51736673
5	sperm capacitation (GO:0048240)	8.46435722
6	plasma membrane fusion (GO:0045026)	8.30960620
7	single strand break repair (GO:0000012)	8.17678746
8	microtubule depolymerization (GO:0007019)	8.14835111
9	spermatid development (GO:0007286)	8.05911362
10	sperm-egg recognition (GO:0035036)	7.81677322
11	multicellular organism reproduction (GO:0032504)	7.65415174
12	binding of sperm to zona pellucida (GO:0007339)	7.27970959
13	reproduction (GO:0000003)	7.16013651
14	rRNA methylation (GO:0031167)	7.13451932
15	microtubule polymerization or depolymerization (GO:0031109)	6.88085473
16	sexual reproduction (GO:0019953)	6.81490751
17	protein polyglutamylation (GO:0018095)	6.79816669
18	calcium ion-dependent exocytosis (GO:0017156)	6.63103211
19	cell-cell recognition (GO:0009988)	6.44075188
20	spermatogenesis (GO:0007283)	6.24421252
21	rRNA modification (GO:0000154)	6.24286744
22	male gamete generation (GO:0048232)	6.22419837
23	protein targeting to Golgi (GO:0000042)	6.13046449
24	axonemal dynein complex assembly (GO:0070286)	6.01731531
25	cellular ketone body metabolic process (GO:0046950)	5.98676450
26	negative regulation of inclusion body assembly (GO:0090084)	5.92386444
27	establishment of protein localization to Golgi (GO:0072600)	5.91848014
28	phosphatidylethanolamine biosynthetic process (GO:0006646)	5.72937456
29	gamete generation (GO:0007276)	5.71050064
30	retrograde transport, vesicle recycling within Golgi (GO:0000301)	5.68199787
31	centriole replication (GO:0007099)	5.68060331
32	microtubule severing (GO:0051013)	5.48315051
33	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	5.29379825
34	phosphatidylethanolamine metabolic process (GO:0046337)	5.27490263
35	ketone body metabolic process (GO:1902224)	5.26348086
36	single fertilization (GO:0007338)	5.18188191
37	chromatin silencing (GO:0006342)	5.00860396
38	cell wall macromolecule catabolic process (GO:0016998)	4.98865647
39	positive regulation of Rab GTPase activity (GO:0032851)	4.92372879
40	regulation of Rab GTPase activity (GO:0032313)	4.92372879
41	cell wall macromolecule metabolic process (GO:0044036)	4.87697024
42	regulation of cilium movement (GO:0003352)	4.78157646
43	centriole assembly (GO:0098534)	4.73969837
44	germ cell development (GO:0007281)	4.62400470
45	multicellular organismal reproductive process (GO:0048609)	4.54697105
46	protein localization to Golgi apparatus (GO:0034067)	4.53962402
47	motile cilium assembly (GO:0044458)	4.47940887
48	regulation of inclusion body assembly (GO:0090083)	4.46233806
49	regulation of centriole replication (GO:0046599)	4.42834742
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.33356522
51	RNA destabilization (GO:0050779)	4.32985754
52	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.32651680
53	fertilization (GO:0009566)	4.29818330
54	seminiferous tubule development (GO:0072520)	4.16594631
55	glomerular visceral epithelial cell development (GO:0072015)	4.11747266
56	regulation of transcription involved in cell fate commitment (GO:0060850)	4.11131322
57	epithelial cilium movement (GO:0003351)	4.09443705
58	nucleus organization (GO:0006997)	4.07908557
59	coenzyme catabolic process (GO:0009109)	4.07594085
60	glomerular epithelial cell development (GO:0072310)	3.87776511
61	glycerol ether metabolic process (GO:0006662)	3.86133737
62	histone H3-K9 demethylation (GO:0033169)	3.61911550
63	ether metabolic process (GO:0018904)	3.54705106
64	response to acidic pH (GO:0010447)	3.54251139
65	cilium movement (GO:0003341)	3.48427603
66	negative regulation of gene expression, epigenetic (GO:0045814)	3.47587758
67	male meiosis I (GO:0007141)	3.45899282
68	negative regulation of Rho protein signal transduction (GO:0035024)	3.45885069
69	cellular response to pH (GO:0071467)	3.41603055
70	musculoskeletal movement (GO:0050881)	3.36592941
71	multicellular organismal movement (GO:0050879)	3.36592941
72	organic cation transport (GO:0015695)	3.19100046
73	male meiosis (GO:0007140)	3.10417290
74	microtubule nucleation (GO:0007020)	3.08538789
75	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.07103668
76	polyamine biosynthetic process (GO:0006596)	3.05782379
77	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.01761525
78	cell recognition (GO:0008037)	3.00464230
79	multicellular organismal development (GO:0007275)	2.99899138
80	regulation of microtubule-based movement (GO:0060632)	2.95911167
81	DNA conformation change (GO:0071103)	2.95513770
82	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.93912879
83	cerebral cortex neuron differentiation (GO:0021895)	2.92770795
84	receptor recycling (GO:0001881)	2.92622183
85	NAD biosynthetic process (GO:0009435)	2.92303834
86	nucleosome disassembly (GO:0006337)	2.87342822
87	protein-DNA complex disassembly (GO:0032986)	2.87342822
88	peptidyl-proline hydroxylation (GO:0019511)	2.85137003
89	membrane protein intracellular domain proteolysis (GO:0031293)	2.84061626
90	protein depolymerization (GO:0051261)	2.84000812
91	piRNA metabolic process (GO:0034587)	2.82555841
92	histone exchange (GO:0043486)	2.76596369
93	regulation of interleukin-13 production (GO:0032656)	2.75172812
94	regulation of T-helper 2 cell differentiation (GO:0045628)	2.74787796
95	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.74310200
96	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.74310200
97	cell differentiation involved in metanephros development (GO:0072202)	2.72905483
98	acrosome reaction (GO:0007340)	12.2382357
99	sperm motility (GO:0030317)	11.2645639
100	fusion of sperm to egg plasma membrane (GO:0007342)	10.9796338

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.83906588
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.55074274
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.42531490
4	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.42568808
5	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.28768538
6	CBP_20019798_ChIP-Seq_JUKART_Human	2.28768538
7	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.23959903
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23959903
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.16374617
10	ERA_21632823_ChIP-Seq_H3396_Human	2.15519335
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.08291366
12	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.06524942
13	FUS_26573619_Chip-Seq_HEK293_Human	2.00868821
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.00334866
15	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.94318088
16	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.93685519
17	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93150281
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.92627839
19	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.90593387
20	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.90088286
21	NANOG_20526341_ChIP-Seq_ESCs_Human	1.85296069
22	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.83786187
23	* RAC3_21632823_ChIP-Seq_H3396_Human	1.81267169
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.79597668
25	MYC_19829295_ChIP-Seq_ESCs_Human	1.76106002
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75089937
27	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.67444476
28	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.67240655
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.66871541
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.63534459
31	E2F1_20622854_ChIP-Seq_HELA_Human	1.63347408
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.59552911
33	AR_25329375_ChIP-Seq_VCAP_Human	1.56080468
34	CTCF_27219007_Chip-Seq_Bcells_Human	1.55677171
35	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.54849043
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54600789
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.53820089
38	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.53262888
39	PHF8_20622854_ChIP-Seq_HELA_Human	1.50522421
40	OCT4_20526341_ChIP-Seq_ESCs_Human	1.50496994
41	RBPJ_21746931_ChIP-Seq_IB4_Human	1.50309844
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.50202014
43	DROSHA_22980978_ChIP-Seq_HELA_Human	1.50174635
44	BCOR_27268052_Chip-Seq_Bcells_Human	1.49577190
45	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.46993784
46	CTCF_20526341_ChIP-Seq_ESCs_Human	1.46208521
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.45018324
48	P300_19829295_ChIP-Seq_ESCs_Human	1.44258938
49	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.42777431
50	P300_27268052_Chip-Seq_Bcells_Human	1.41565433
51	ETV1_20927104_ChIP-Seq_GIST48_Human	1.41221865
52	SMC4_20622854_ChIP-Seq_HELA_Human	1.41081728
53	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.40873979
54	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.40511726
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38167100
56	NFYB_21822215_ChIP-Seq_K562_Human	1.36829734
57	VDR_22108803_ChIP-Seq_LS180_Human	1.35562383
58	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.35226797
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.34337745
60	CEBPB_22108803_ChIP-Seq_LS180_Human	1.33345270
61	P68_20966046_ChIP-Seq_HELA_Human	1.33197026
62	P53_21459846_ChIP-Seq_SAOS-2_Human	1.32700770
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.31663342
64	TBL1_22424771_ChIP-Seq_293T_Human	1.31492755
65	* TP63_22573176_ChIP-Seq_HFKS_Human	1.31359428
66	HOXB7_26014856_ChIP-Seq_BT474_Human	1.29542207
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.29115990
68	PHF8_20622853_ChIP-Seq_HELA_Human	1.28555199
69	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.25139148
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24924312
71	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.24750044
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24023814
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24023814
74	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21984341
75	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.21329567
76	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.20860573
77	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.20311425
78	SMRT_27268052_Chip-Seq_Bcells_Human	1.18704938
79	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.16679931
80	TAF15_26573619_Chip-Seq_HEK293_Human	1.16131238
81	RUNX2_22187159_ChIP-Seq_PCA_Human	1.15416473
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15045042
83	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11134761
84	* P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.09317067
85	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.08115209
86	SA1_27219007_Chip-Seq_Bcells_Human	1.08005301
87	NFYA_21822215_ChIP-Seq_K562_Human	1.07232276
88	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06977119
89	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.06670011
90	STAT3_23295773_ChIP-Seq_U87_Human	1.06506839
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05960647
92	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.05955288
93	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05675894
94	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.04915755
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04665533
96	SMAD4_21799915_ChIP-Seq_A2780_Human	1.04056523
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02614873
98	AR_21572438_ChIP-Seq_LNCaP_Human	1.01455135
99	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99936155
100	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99899829

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.06011138
2	MP0005377_hearing/vestibular/ear_phenot	5.06011138
3	MP0003698_abnormal_male_reproductive	4.27195246
4	MP0001929_abnormal_gametogenesis	3.86930600
5	MP0005670_abnormal_white_adipose	3.80473580
6	MP0001348_abnormal_lacrimal_gland	3.57564590
7	MP0003718_maternal_effect	2.53912487
8	MP0003011_delayed_dark_adaptation	2.46159191
9	MP0005379_endocrine/exocrine_gland_phen	2.39936288
10	MP0000678_abnormal_parathyroid_gland	2.39026832
11	MP0002161_abnormal_fertility/fecundity	2.36780109
12	MP0002132_abnormal_respiratory_system	2.15874813
13	MP0005423_abnormal_somatic_nervous	2.10406334
14	MP0005410_abnormal_fertilization	11.7191425
15	MP0002210_abnormal_sex_determination	1.90826522
16	MP0002234_abnormal_pharynx_morphology	1.79898765
17	MP0002282_abnormal_trachea_morphology	1.76560285
18	MP0002249_abnormal_larynx_morphology	1.70252334
19	MP0003646_muscle_fatigue	1.69695062
20	MP0008877_abnormal_DNA_methylation	1.67517809
21	MP0001968_abnormal_touch/_nociception	1.64024375
22	MP0001485_abnormal_pinna_reflex	1.60748853
23	MP0001486_abnormal_startle_reflex	1.50580923
24	MP0001145_abnormal_male_reproductive	1.46802762
25	MP0000653_abnormal_sex_gland	1.43426626
26	MP0002735_abnormal_chemical_nociception	1.41675266
27	MP0009053_abnormal_anal_canal	1.36055338
28	MP0006292_abnormal_olfactory_placode	1.32262817
29	MP0004742_abnormal_vestibular_system	1.31997553
30	MP0003879_abnormal_hair_cell	1.23065448
31	MP0005395_other_phenotype	1.19499446
32	MP0005310_abnormal_salivary_gland	1.16757011
33	MP0001765_abnormal_ion_homeostasis	1.15954628
34	MP0000049_abnormal_middle_ear	1.11436769
35	MP0002822_catalepsy	1.09780877
36	MP0001963_abnormal_hearing_physiology	1.08657752
37	MP0005551_abnormal_eye_electrophysiolog	1.06433473
38	MP0009697_abnormal_copulation	1.06121737
39	MP0002138_abnormal_hepatobiliary_system	1.02137777
40	MP0000534_abnormal_ureter_morphology	1.00818683
41	MP0006276_abnormal_autonomic_nervous	1.00457027
42	MP0000681_abnormal_thyroid_gland	0.97994638
43	MP0000026_abnormal_inner_ear	0.96868925
44	MP0002127_abnormal_cardiovascular_syste	0.90982836
45	MP0002733_abnormal_thermal_nociception	0.87454309
46	MP0004510_myositis	0.87442586
47	MP0002229_neurodegeneration	0.87280478
48	MP0003950_abnormal_plasma_membrane	0.87027680
49	MP0004859_abnormal_synaptic_plasticity	0.84280155
50	MP0004270_analgesia	0.81827132
51	MP0009745_abnormal_behavioral_response	0.75065221
52	MP0002067_abnormal_sensory_capabilities	0.72508819
53	MP0001970_abnormal_pain_threshold	0.71882505
54	MP0002557_abnormal_social/conspecific_i	0.70943393
55	MP0001984_abnormal_olfaction	0.68869821
56	MP0000372_irregular_coat_pigmentation	0.68866039
57	MP0005248_abnormal_Harderian_gland	0.68195316
58	MP0005636_abnormal_mineral_homeostasis	0.68085739
59	MP0003077_abnormal_cell_cycle	0.67901887
60	MP0005084_abnormal_gallbladder_morpholo	0.65592593
61	MP0002254_reproductive_system_inflammat	0.64916633
62	MP0001501_abnormal_sleep_pattern	0.64521383
63	MP0004085_abnormal_heartbeat	0.64489427
64	MP0002928_abnormal_bile_duct	0.62618775
65	MP0005451_abnormal_body_composition	0.61863110
66	MP0001293_anophthalmia	0.59808044
67	MP0000955_abnormal_spinal_cord	0.59182761
68	MP0003880_abnormal_central_pattern	0.58119041
69	MP0002734_abnormal_mechanical_nocicepti	0.58020483
70	MP0009115_abnormal_fat_cell	0.57937719
71	MP0008569_lethality_at_weaning	0.56243069
72	MP0003936_abnormal_reproductive_system	0.55854790
73	MP0002163_abnormal_gland_morphology	0.54699479
74	MP0001905_abnormal_dopamine_level	0.54277656
75	MP0002572_abnormal_emotion/affect_behav	0.54043444
76	MP0010386_abnormal_urinary_bladder	0.53975678
77	MP0005253_abnormal_eye_physiology	0.53593432
78	MP0002272_abnormal_nervous_system	0.53286470
79	MP0000230_abnormal_systemic_arterial	0.52353606
80	MP0008789_abnormal_olfactory_epithelium	0.51325063
81	MP0001440_abnormal_grooming_behavior	0.50438592
82	MP0000516_abnormal_urinary_system	0.50047163
83	MP0005367_renal/urinary_system_phenotyp	0.50047163
84	MP0001270_distended_abdomen	0.49290568
85	MP0000470_abnormal_stomach_morphology	0.48414581
86	MP0005332_abnormal_amino_acid	0.45226752
87	MP0002653_abnormal_ependyma_morphology	0.44555463
88	MP0003137_abnormal_impulse_conducting	0.43845690
89	MP0001666_abnormal_nutrient_absorption	0.43391701
90	MP0003699_abnormal_female_reproductive	0.43099945
91	MP0001879_abnormal_lymphatic_vessel	0.40458279
92	MP0008995_early_reproductive_senescence	0.40209801
93	MP0005535_abnormal_body_temperature	0.37999536
94	MP0000467_abnormal_esophagus_morphology	0.37551618
95	MP0003119_abnormal_digestive_system	0.35130728
96	MP0003938_abnormal_ear_development	0.34603144
97	MP0002168_other_aberrant_phenotype	0.34467183
98	MP0005391_vision/eye_phenotype	0.34244383
99	MP0003136_yellow_coat_color	0.33947157
100	MP0010329_abnormal_lipoprotein_level	0.33879449

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	9.12805354
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.82641667
3	Absent/shortened dynein arms (HP:0200106)	5.82641667
4	Attenuation of retinal blood vessels (HP:0007843)	5.17989397
5	Bony spicule pigmentary retinopathy (HP:0007737)	5.14869522
6	Asymmetric septal hypertrophy (HP:0001670)	4.58525395
7	Abnormal respiratory motile cilium physiology (HP:0012261)	4.35835680
8	Abnormal ciliary motility (HP:0012262)	4.34285085
9	Chronic hepatic failure (HP:0100626)	4.33916266
10	Tubulointerstitial nephritis (HP:0001970)	4.33292029
11	Abnormal rod and cone electroretinograms (HP:0008323)	4.29353974
12	Abnormal respiratory motile cilium morphology (HP:0005938)	4.17968190
13	Abnormal respiratory epithelium morphology (HP:0012253)	4.17968190
14	Abnormality of macular pigmentation (HP:0008002)	3.97525665
15	Infertility (HP:0000789)	3.92013595
16	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.76930290
17	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.76805807
18	Resting tremor (HP:0002322)	3.69795368
19	Bell-shaped thorax (HP:0001591)	3.68661944
20	Male infertility (HP:0003251)	3.68275825
21	Cone-rod dystrophy (HP:0000548)	3.66423061
22	Azoospermia (HP:0000027)	3.61651118
23	Hyperkalemia (HP:0002153)	3.58288490
24	Potter facies (HP:0002009)	3.57644308
25	Facial shape deformation (HP:0011334)	3.57644308
26	Enlarged epiphyses (HP:0010580)	3.54666766
27	Nasal polyposis (HP:0100582)	3.50932875
28	Abnormal spermatogenesis (HP:0008669)	3.43710065
29	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.35077754
30	Abnormality of dental color (HP:0011073)	3.30085871
31	Hypoplastic ischia (HP:0003175)	3.20733170
32	Hypoplasia of the thymus (HP:0000778)	3.02213857
33	Impulsivity (HP:0100710)	2.94199296
34	Progressive sensorineural hearing impairment (HP:0000408)	2.93245056
35	Abnormality of the ischium (HP:0003174)	2.76951653
36	Amelogenesis imperfecta (HP:0000705)	2.74854063
37	Rhinitis (HP:0012384)	2.73681291
38	Abnormal urine output (HP:0012590)	2.73466438
39	Abnormality of the nasal mucosa (HP:0000433)	2.70176570
40	Recurrent corneal erosions (HP:0000495)	2.68102721
41	Abnormality of the aortic arch (HP:0012303)	2.64704809
42	Nephronophthisis (HP:0000090)	2.63877942
43	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.60963740
44	Polydipsia (HP:0001959)	2.57906667
45	Abnormal drinking behavior (HP:0030082)	2.57906667
46	Insulin-resistant diabetes mellitus (HP:0000831)	2.48645408
47	Stage 5 chronic kidney disease (HP:0003774)	2.48621915
48	Renal dysplasia (HP:0000110)	2.48401919
49	Hypophosphatemic rickets (HP:0004912)	2.47155355
50	Hyperthyroidism (HP:0000836)	2.46905507
51	Congenital malformation of the right heart (HP:0011723)	2.41531229
52	Double outlet right ventricle (HP:0001719)	2.41531229
53	Unilateral renal agenesis (HP:0000122)	2.39092303
54	Hypoalbuminemia (HP:0003073)	2.36835738
55	Abnormal albumin level (HP:0012116)	2.36835738
56	Abnormality of the renal medulla (HP:0100957)	2.35258412
57	Generalized aminoaciduria (HP:0002909)	2.34737825
58	Abnormality of renal excretion (HP:0011036)	2.33388076
59	Polyuria (HP:0000103)	2.32595915
60	Abnormality of potassium homeostasis (HP:0011042)	2.28273920
61	Portal hypertension (HP:0001409)	2.27643549
62	Abnormality of the parathyroid morphology (HP:0011766)	2.27209326
63	Sensory axonal neuropathy (HP:0003390)	2.27108889
64	Hypoparathyroidism (HP:0000829)	2.26696409
65	Progressive cerebellar ataxia (HP:0002073)	2.25389870
66	Renal Fanconi syndrome (HP:0001994)	2.20403710
67	Tetany (HP:0001281)	2.19183894
68	Hypoalphalipoproteinemia (HP:0003233)	2.17039423
69	Renovascular hypertension (HP:0100817)	2.15364725
70	Tubulointerstitial abnormality (HP:0001969)	2.15201992
71	Spastic paraparesis (HP:0002313)	2.12661179
72	Pancreatic fibrosis (HP:0100732)	2.12073092
73	Abnormality of the costochondral junction (HP:0000919)	2.11228722
74	Postural instability (HP:0002172)	2.10527553
75	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.08835983
76	Abnormality of the hepatic vasculature (HP:0006707)	2.06165874
77	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.05727327
78	Absent epiphyses (HP:0010577)	2.05727327
79	Bronchiectasis (HP:0002110)	2.04554665
80	Truncal obesity (HP:0001956)	2.04479580
81	Optic nerve hypoplasia (HP:0000609)	2.02734161
82	Muscle fiber atrophy (HP:0100295)	2.02492055
83	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.02086942
84	Median cleft lip (HP:0000161)	2.01628763
85	Flat capital femoral epiphysis (HP:0003370)	1.99028005
86	Hyponatremia (HP:0002902)	1.98779964
87	Abnormality of the femoral head (HP:0003368)	1.97367676
88	Horizontal nystagmus (HP:0000666)	1.96999772
89	Pendular nystagmus (HP:0012043)	1.95312679
90	Chronic bronchitis (HP:0004469)	1.93458934
91	Scotoma (HP:0000575)	1.93300864
92	Flattened epiphyses (HP:0003071)	1.93005726
93	Tubular atrophy (HP:0000092)	1.92834282
94	Osteomalacia (HP:0002749)	1.91841249
95	Abnormality of femoral epiphyses (HP:0006499)	1.89743086
96	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.89743086
97	Decreased central vision (HP:0007663)	1.87436761
98	Congenital sensorineural hearing impairment (HP:0008527)	1.87349170
99	Photophobia (HP:0000613)	1.87146140
100	Cerebellar dysplasia (HP:0007033)	1.84679655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.27745143
2	TESK1	4.72585441
3	MAP4K2	4.52850489
4	DDR2	4.03916992
5	INSRR	3.84892323
6	PLK2	3.41475912
7	PNCK	3.21598198
8	TRIM28	2.85319960
9	STK38	2.52162605
10	BRD4	2.28254402
11	WNK1	2.07122288
12	MAPK15	2.00283564
13	PRKD3	1.98376837
14	STK38L	1.97643575
15	CAMK1G	1.92181367
16	STK39	1.91687965
17	PIK3CG	1.85584409
18	WNK4	1.81021435
19	MAP3K9	1.65462201
20	BRSK2	1.54628109
21	CDK12	1.53309480
22	BMPR1B	1.50895443
23	MST1R	1.41062168
24	CDK7	1.33206995
25	OXSR1	1.25700074
26	MUSK	1.21102126
27	PDPK1	1.21086904
28	PDK1	1.20202393
29	NEK6	1.12906906
30	BRSK1	1.03910742
31	DYRK1B	0.97960632
32	MAP3K11	0.91942746
33	LATS2	0.91405673
34	MATK	0.91340440
35	PTK2B	0.85334722
36	FRK	0.84112346
37	BRAF	0.83416456
38	AKT3	0.79328944
39	PRKAA2	0.75773874
40	ARAF	0.74816823
41	KSR2	0.70111080
42	TNIK	0.56904870
43	MAP3K1	0.54828521
44	ROCK1	0.54665427
45	TAF1	0.52055815
46	PRKG1	0.50456893
47	PKN1	0.47564144
48	CDK3	0.46227677
49	PRKG2	0.43335886
50	SIK2	0.43001594
51	RPS6KA1	0.42738430
52	CAMK1	0.42141190
53	MAP3K8	0.41084673
54	TLK1	0.38852184
55	TYRO3	0.38585612
56	CDK1	0.37066990
57	GSK3B	0.36808697
58	MET	0.36550316
59	PASK	0.36435759
60	PRKCG	0.35486516
61	MAP3K13	0.35281981
62	CDK2	0.34921594
63	MAPK1	0.32098814
64	MAP3K2	0.29647197
65	UHMK1	0.29634461
66	CHEK1	0.28575206
67	PINK1	0.28527330
68	CAMK1D	0.28253970
69	NTRK1	0.28046159
70	AURKA	0.23730142
71	MTOR	0.23542395
72	KIT	0.20414700
73	PRKCZ	0.20300749
74	IKBKB	0.20106470
75	PRKCQ	0.19671955
76	MAPK14	0.19643890
77	PLK1	0.17884386
78	JAK3	0.16869512
79	PRKCE	0.16575476
80	MAPK8	0.16176949
81	SGK1	0.15426023
82	ADRBK2	0.14669391
83	CDK4	0.14421951
84	TIE1	0.13944468
85	PRKCB	0.13891819
86	AKT1	0.13757100
87	FER	0.13351870
88	RPS6KA2	0.12930984
89	PRKAA1	0.11718205
90	TESK2	0.10516162
91	MKNK2	0.09934470
92	DYRK2	0.09809153
93	MST4	0.09116658
94	MARK1	0.08974847
95	PRKACA	0.08909095
96	MAP3K10	0.08839310
97	PRKACB	0.08569246
98	CDK19	0.08247083
99	IGF1R	0.07114693
100	CAMKK2	0.07011059

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	8.82971587
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.83557305
3	Olfactory transduction_Homo sapiens_hsa04740	4.02965009
4	Butanoate metabolism_Homo sapiens_hsa00650	2.95615677
5	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18718676
6	Allograft rejection_Homo sapiens_hsa05330	2.11909750
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.08695571
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.00104065
9	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.81997797
10	Antigen processing and presentation_Homo sapiens_hsa04612	1.79999575
11	RNA transport_Homo sapiens_hsa03013	1.77384662
12	Taste transduction_Homo sapiens_hsa04742	1.77203797
13	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.74158537
14	Arginine and proline metabolism_Homo sapiens_hsa00330	1.46417560
15	Phenylalanine metabolism_Homo sapiens_hsa00360	1.39336570
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39246511
17	Fatty acid metabolism_Homo sapiens_hsa01212	1.37754775
18	Fatty acid degradation_Homo sapiens_hsa00071	1.26815289
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.26354521
20	Basal transcription factors_Homo sapiens_hsa03022	1.25682130
21	Salivary secretion_Homo sapiens_hsa04970	1.24730029
22	Type II diabetes mellitus_Homo sapiens_hsa04930	1.24618488
23	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.21060121
24	Phototransduction_Homo sapiens_hsa04744	1.19380732
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.16771646
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.15367629
27	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.13805664
28	Viral myocarditis_Homo sapiens_hsa05416	1.13275062
29	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.11699008
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11159352
31	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.09233440
32	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.04768840
33	Endocytosis_Homo sapiens_hsa04144	1.02461512
34	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.02340182
35	Fanconi anemia pathway_Homo sapiens_hsa03460	0.99981928
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96334558
37	Oocyte meiosis_Homo sapiens_hsa04114	0.90635420
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.90417354
39	Tyrosine metabolism_Homo sapiens_hsa00350	0.90329770
40	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.88564489
41	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86690072
42	Protein digestion and absorption_Homo sapiens_hsa04974	0.86114587
43	Retinol metabolism_Homo sapiens_hsa00830	0.85724484
44	mRNA surveillance pathway_Homo sapiens_hsa03015	0.84262448
45	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.83846921
46	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.83006023
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.81911409
48	Purine metabolism_Homo sapiens_hsa00230	0.79711409
49	Influenza A_Homo sapiens_hsa05164	0.78640417
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73772715
51	Calcium signaling pathway_Homo sapiens_hsa04020	0.70457719
52	Nicotine addiction_Homo sapiens_hsa05033	0.69252387
53	Tryptophan metabolism_Homo sapiens_hsa00380	0.67144310
54	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.64172599
55	Insulin secretion_Homo sapiens_hsa04911	0.63979442
56	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.63171196
57	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56820963
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.56092136
59	Morphine addiction_Homo sapiens_hsa05032	0.53534072
60	ABC transporters_Homo sapiens_hsa02010	0.50133662
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.49591469
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49275141
63	Circadian entrainment_Homo sapiens_hsa04713	0.48461756
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47084288
65	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45802124
66	PPAR signaling pathway_Homo sapiens_hsa03320	0.44615341
67	Renin-angiotensin system_Homo sapiens_hsa04614	0.44463329
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.42678669
69	Glutamatergic synapse_Homo sapiens_hsa04724	0.40385324
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.38510032
71	Legionellosis_Homo sapiens_hsa05134	0.36863720
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.36171072
73	Huntingtons disease_Homo sapiens_hsa05016	0.35923181
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.35748485
75	Renin secretion_Homo sapiens_hsa04924	0.33941741
76	Circadian rhythm_Homo sapiens_hsa04710	0.33744208
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.33337488
78	Metabolic pathways_Homo sapiens_hsa01100	0.31197674
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.29845488
80	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.29614035
81	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.29564463
82	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.29301630
83	Bile secretion_Homo sapiens_hsa04976	0.28815264
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.27518201
85	Propanoate metabolism_Homo sapiens_hsa00640	0.27428981
86	Primary immunodeficiency_Homo sapiens_hsa05340	0.25532971
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.25008007
88	Gastric acid secretion_Homo sapiens_hsa04971	0.24677128
89	Homologous recombination_Homo sapiens_hsa03440	0.24054805
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23057453
91	Pancreatic secretion_Homo sapiens_hsa04972	0.23049792
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.22978878
93	Peroxisome_Homo sapiens_hsa04146	0.22349865
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.19999328
95	Estrogen signaling pathway_Homo sapiens_hsa04915	0.19079060
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.18668985
97	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.18625251
98	RNA polymerase_Homo sapiens_hsa03020	0.17810975
99	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.17660506
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.17650864

C17ORF98

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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