ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.47002129
2	behavioral response to nicotine (GO:0035095)	5.25671998
3	protein-cofactor linkage (GO:0018065)	4.70482520
4	fucose catabolic process (GO:0019317)	4.47199177
5	L-fucose metabolic process (GO:0042354)	4.47199177
6	L-fucose catabolic process (GO:0042355)	4.47199177
7	indolalkylamine metabolic process (GO:0006586)	3.73720947
8	cellular ketone body metabolic process (GO:0046950)	3.72821411
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63450487
10	negative regulation of mast cell activation (GO:0033004)	3.63151679
11	tryptophan catabolic process (GO:0006569)	3.56896616
12	indole-containing compound catabolic process (GO:0042436)	3.56896616
13	indolalkylamine catabolic process (GO:0046218)	3.56896616
14	platelet dense granule organization (GO:0060155)	3.55762470
15	ketone body metabolic process (GO:1902224)	3.49805827
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.41919135
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.39622814
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.39622814
19	tryptophan metabolic process (GO:0006568)	3.38955104
20	rRNA catabolic process (GO:0016075)	3.35993141
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.33911762
22	NADH dehydrogenase complex assembly (GO:0010257)	3.33911762
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.33911762
24	DNA deamination (GO:0045006)	3.33555362
25	centriole replication (GO:0007099)	3.33433040
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30107618
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.29602276
28	detection of light stimulus involved in visual perception (GO:0050908)	3.29602276
29	kynurenine metabolic process (GO:0070189)	3.28017534
30	replication fork processing (GO:0031297)	3.26420189
31	axoneme assembly (GO:0035082)	3.24231783
32	mannosylation (GO:0097502)	3.22314230
33	piRNA metabolic process (GO:0034587)	3.15088815
34	protein complex biogenesis (GO:0070271)	3.14531314
35	respiratory chain complex IV assembly (GO:0008535)	3.12140332
36	negative regulation of telomere maintenance (GO:0032205)	3.10007392
37	regulation of cilium movement (GO:0003352)	3.03485947
38	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.02799481
39	epithelial cilium movement (GO:0003351)	3.02286782
40	synapsis (GO:0007129)	2.99467616
41	meiotic chromosome segregation (GO:0045132)	2.98865691
42	mitochondrial respiratory chain complex assembly (GO:0033108)	2.97038142
43	water-soluble vitamin biosynthetic process (GO:0042364)	2.94103658
44	DNA double-strand break processing (GO:0000729)	2.91594191
45	indole-containing compound metabolic process (GO:0042430)	2.89029413
46	recombinational repair (GO:0000725)	2.88272012
47	neural tube formation (GO:0001841)	2.87873775
48	double-strand break repair via homologous recombination (GO:0000724)	2.87245753
49	protein localization to cilium (GO:0061512)	2.83552844
50	pseudouridine synthesis (GO:0001522)	2.82959910
51	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.79522052
52	sulfation (GO:0051923)	2.78079157
53	S-adenosylmethionine metabolic process (GO:0046500)	2.76818441
54	protein import into peroxisome matrix (GO:0016558)	2.76672011
55	ATP synthesis coupled proton transport (GO:0015986)	2.74733340
56	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74733340
57	DNA methylation involved in gamete generation (GO:0043046)	2.74233575
58	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.72842100
59	cytochrome complex assembly (GO:0017004)	2.69456794
60	nonmotile primary cilium assembly (GO:0035058)	2.69385618
61	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.67897630
62	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.66116563
63	ubiquinone biosynthetic process (GO:0006744)	2.65102714
64	cellular response to ATP (GO:0071318)	2.64105475
65	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.63562716
66	anterograde synaptic vesicle transport (GO:0048490)	2.61331187
67	ubiquinone metabolic process (GO:0006743)	2.60940505
68	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.60170942
69	maturation of 5.8S rRNA (GO:0000460)	2.58710200
70	resolution of meiotic recombination intermediates (GO:0000712)	2.57927202
71	neuronal action potential (GO:0019228)	2.57557966
72	protein polyglutamylation (GO:0018095)	2.55734593
73	multicellular organism reproduction (GO:0032504)	2.55709122
74	fucosylation (GO:0036065)	2.55436178
75	cornea development in camera-type eye (GO:0061303)	2.53916487
76	reciprocal DNA recombination (GO:0035825)	2.53736160
77	reciprocal meiotic recombination (GO:0007131)	2.53736160
78	intracellular protein transmembrane import (GO:0044743)	2.53268668
79	primary amino compound metabolic process (GO:1901160)	2.52755386
80	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.51359552
81	cilium organization (GO:0044782)	2.49324919
82	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.48164611
83	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.48164611
84	GPI anchor metabolic process (GO:0006505)	2.47980455
85	cilium morphogenesis (GO:0060271)	2.47822726
86	regulation of microtubule-based movement (GO:0060632)	2.47642236
87	nephron tubule morphogenesis (GO:0072078)	2.47083971
88	nephron epithelium morphogenesis (GO:0072088)	2.47083971
89	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.47012910
90	intraciliary transport (GO:0042073)	2.46219503
91	serotonin metabolic process (GO:0042428)	2.45437114
92	retinal cone cell development (GO:0046549)	2.44065852
93	male meiosis I (GO:0007141)	2.44017200
94	behavioral response to ethanol (GO:0048149)	2.43772592
95	photoreceptor cell development (GO:0042461)	2.43422825
96	tRNA processing (GO:0008033)	2.42365219
97	DNA replication checkpoint (GO:0000076)	2.42229763
98	cilium assembly (GO:0042384)	2.40304831
99	synaptic transmission, cholinergic (GO:0007271)	2.38361958
100	amine catabolic process (GO:0009310)	2.38072739

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.29973068
2	VDR_22108803_ChIP-Seq_LS180_Human	3.76886061
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90421507
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.72064981
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.66773396
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.60954199
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.60520795
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59905879
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.54154360
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.39698548
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.32721309
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31449814
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.20236259
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.15353136
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.13095693
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.10853400
17	FUS_26573619_Chip-Seq_HEK293_Human	2.08847283
18	EWS_26573619_Chip-Seq_HEK293_Human	2.03352238
19	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.96342406
20	MYC_18940864_ChIP-ChIP_HL60_Human	1.96329985
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.94621152
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.92425575
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.86153208
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.85974231
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84434840
26	GATA1_22025678_ChIP-Seq_K562_Human	1.77644835
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.76317850
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75385600
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.73969483
30	TP53_22573176_ChIP-Seq_HFKS_Human	1.72965826
31	ER_23166858_ChIP-Seq_MCF-7_Human	1.66851366
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.64135675
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62421198
34	P300_19829295_ChIP-Seq_ESCs_Human	1.62219638
35	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56473617
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47993643
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47627390
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42674377
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42674377
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.42067281
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.40197796
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39693256
43	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34201853
44	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32766721
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.32766721
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.32695428
47	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.30094791
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.30094791
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.29713411
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29577535
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26490124
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26490124
53	* STAT3_23295773_ChIP-Seq_U87_Human	1.25632572
54	AR_20517297_ChIP-Seq_VCAP_Human	1.25199810
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23808046
56	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22456805
57	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.22065698
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21691456
59	NCOR_22424771_ChIP-Seq_293T_Human	1.20958964
60	* TCF4_23295773_ChIP-Seq_U87_Human	1.20321847
61	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19922164
62	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19192247
63	REST_21632747_ChIP-Seq_MESCs_Mouse	1.17058092
64	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16239811
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16229795
66	AR_25329375_ChIP-Seq_VCAP_Human	1.15399746
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13608779
68	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.13080197
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.10292134
70	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09316165
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07863219
72	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07510903
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.07430796
74	ERA_21632823_ChIP-Seq_H3396_Human	1.06530642
75	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04100983
76	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03360854
77	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03261111
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03052888
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.02356286
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00698460
81	MYC_19829295_ChIP-Seq_ESCs_Human	1.00623448
82	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00399607
83	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99648997
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98945720
85	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.98913470
86	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98587868
87	* GATA3_26560356_Chip-Seq_TH2_Human	0.97933915
88	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97835530
89	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97246594
90	SMAD4_21799915_ChIP-Seq_A2780_Human	0.96541200
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.95771783
92	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.94310147
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93803725
94	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93365139
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92072882
96	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.91982088
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.91916532
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.91863358
99	RNF2_27304074_Chip-Seq_NSC_Mouse	0.91786526
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91476868

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.57639828
2	MP0002102_abnormal_ear_morphology	2.39029949
3	MP0003195_calcinosis	2.32465044
4	MP0008877_abnormal_DNA_methylation	2.30348614
5	MP0006292_abnormal_olfactory_placode	2.27086345
6	MP0005551_abnormal_eye_electrophysiolog	2.26105080
7	MP0000569_abnormal_digit_pigmentation	2.25558669
8	MP0005645_abnormal_hypothalamus_physiol	2.19702568
9	MP0008875_abnormal_xenobiotic_pharmacok	2.15376296
10	MP0000372_irregular_coat_pigmentation	2.14107304
11	MP0008995_early_reproductive_senescence	2.14044154
12	MP0001986_abnormal_taste_sensitivity	2.12455275
13	MP0004142_abnormal_muscle_tone	2.06919207
14	MP0003646_muscle_fatigue	1.99764420
15	MP0002638_abnormal_pupillary_reflex	1.94218394
16	MP0006072_abnormal_retinal_apoptosis	1.86868343
17	MP0008872_abnormal_physiological_respon	1.84494862
18	MP0001968_abnormal_touch/_nociception	1.82398205
19	MP0002653_abnormal_ependyma_morphology	1.79153671
20	MP0009046_muscle_twitch	1.78831917
21	MP0002837_dystrophic_cardiac_calcinosis	1.75270248
22	MP0002876_abnormal_thyroid_physiology	1.71197938
23	MP0002938_white_spotting	1.70876750
24	MP0004145_abnormal_muscle_electrophysio	1.69706288
25	MP0005253_abnormal_eye_physiology	1.68671684
26	MP0004133_heterotaxia	1.64110294
27	MP0005174_abnormal_tail_pigmentation	1.63516747
28	MP0003136_yellow_coat_color	1.62380055
29	MP0001501_abnormal_sleep_pattern	1.61706685
30	MP0000631_abnormal_neuroendocrine_gland	1.57217348
31	MP0005646_abnormal_pituitary_gland	1.56281183
32	MP0009745_abnormal_behavioral_response	1.55522341
33	MP0003787_abnormal_imprinting	1.55372879
34	MP0001529_abnormal_vocalization	1.53264404
35	MP0008058_abnormal_DNA_repair	1.51903084
36	MP0003011_delayed_dark_adaptation	1.49684941
37	MP0002736_abnormal_nociception_after	1.47751178
38	MP0004885_abnormal_endolymph	1.46822054
39	MP0008775_abnormal_heart_ventricle	1.46778670
40	MP0002272_abnormal_nervous_system	1.46723320
41	MP0006276_abnormal_autonomic_nervous	1.43439061
42	MP0000427_abnormal_hair_cycle	1.34014771
43	MP0003890_abnormal_embryonic-extraembry	1.33623995
44	MP0004043_abnormal_pH_regulation	1.33500191
45	MP0002234_abnormal_pharynx_morphology	1.32098652
46	MP0002095_abnormal_skin_pigmentation	1.30701195
47	MP0005075_abnormal_melanosome_morpholog	1.29003463
48	MP0003880_abnormal_central_pattern	1.27864252
49	MP0003878_abnormal_ear_physiology	1.27522999
50	MP0005377_hearing/vestibular/ear_phenot	1.27522999
51	MP0002163_abnormal_gland_morphology	1.27125502
52	MP0003718_maternal_effect	1.26757678
53	MP0005084_abnormal_gallbladder_morpholo	1.21847063
54	MP0005171_absent_coat_pigmentation	1.19908231
55	MP0002733_abnormal_thermal_nociception	1.15211859
56	MP0003786_premature_aging	1.15046482
57	MP0002928_abnormal_bile_duct	1.06875629
58	MP0002572_abnormal_emotion/affect_behav	1.06617820
59	MP0002735_abnormal_chemical_nociception	1.05291863
60	MP0001764_abnormal_homeostasis	1.04549538
61	MP0005083_abnormal_biliary_tract	1.04229668
62	MP0001970_abnormal_pain_threshold	1.04131147
63	MP0005423_abnormal_somatic_nervous	1.03041116
64	MP0001984_abnormal_olfaction	1.02525319
65	MP0001485_abnormal_pinna_reflex	1.00394851
66	MP0005379_endocrine/exocrine_gland_phen	0.98972632
67	MP0001929_abnormal_gametogenesis	0.97806797
68	MP0002138_abnormal_hepatobiliary_system	0.97192910
69	MP0002557_abnormal_social/conspecific_i	0.97172305
70	MP0002067_abnormal_sensory_capabilities	0.96937844
71	MP0005386_behavior/neurological_phenoty	0.95588367
72	MP0004924_abnormal_behavior	0.95588367
73	MP0001486_abnormal_startle_reflex	0.93805944
74	MP0000015_abnormal_ear_pigmentation	0.93786202
75	MP0002064_seizures	0.92163901
76	MP0001919_abnormal_reproductive_system	0.91860716
77	MP0005389_reproductive_system_phenotype	0.91423539
78	MP0002751_abnormal_autonomic_nervous	0.90976388
79	MP0003698_abnormal_male_reproductive	0.90485282
80	MP0005195_abnormal_posterior_eye	0.90384036
81	MP0003656_abnormal_erythrocyte_physiolo	0.90272264
82	MP0005332_abnormal_amino_acid	0.89937620
83	MP0001905_abnormal_dopamine_level	0.87948735
84	MP0003121_genomic_imprinting	0.87472747
85	MP0002210_abnormal_sex_determination	0.86684034
86	MP0001324_abnormal_eye_pigmentation	0.84963962
87	MP0002063_abnormal_learning/memory/cond	0.84869321
88	MP0005410_abnormal_fertilization	0.81869221
89	MP0000647_abnormal_sebaceous_gland	0.80188466
90	MP0005636_abnormal_mineral_homeostasis	0.80038485
91	MP0008789_abnormal_olfactory_epithelium	0.79878639
92	MP0006035_abnormal_mitochondrial_morpho	0.78192035
93	MP0000383_abnormal_hair_follicle	0.77934135
94	MP0004742_abnormal_vestibular_system	0.76291121
95	MP0003635_abnormal_synaptic_transmissio	0.75821148
96	MP0001293_anophthalmia	0.74873697
97	MP0004215_abnormal_myocardial_fiber	0.74866497
98	MP0002229_neurodegeneration	0.74405239
99	MP0002752_abnormal_somatic_nervous	0.74182693
100	MP0000566_synostosis	0.72439334

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.33684504
2	Pancreatic fibrosis (HP:0100732)	3.88037406
3	True hermaphroditism (HP:0010459)	3.68434947
4	Congenital stationary night blindness (HP:0007642)	3.65492583
5	Type II lissencephaly (HP:0007260)	3.54142729
6	Abnormality of midbrain morphology (HP:0002418)	3.49507707
7	Molar tooth sign on MRI (HP:0002419)	3.49507707
8	Abnormality of the renal cortex (HP:0011035)	3.30676116
9	Nephronophthisis (HP:0000090)	3.28248958
10	Attenuation of retinal blood vessels (HP:0007843)	2.90984122
11	Abnormality of the renal medulla (HP:0100957)	2.84502636
12	Renal cortical cysts (HP:0000803)	2.78889479
13	Chronic hepatic failure (HP:0100626)	2.77401455
14	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.71138973
15	Medial flaring of the eyebrow (HP:0010747)	2.69872439
16	Pendular nystagmus (HP:0012043)	2.64681418
17	Concave nail (HP:0001598)	2.64301356
18	Acute necrotizing encephalopathy (HP:0006965)	2.63994657
19	Abnormality of alanine metabolism (HP:0010916)	2.62688198
20	Hyperalaninemia (HP:0003348)	2.62688198
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.62688198
22	Cystic liver disease (HP:0006706)	2.62459337
23	Hypoplasia of the pons (HP:0012110)	2.58144284
24	Mitochondrial inheritance (HP:0001427)	2.55296203
25	Methylmalonic acidemia (HP:0002912)	2.54070236
26	Abnormality of the pons (HP:0007361)	2.53679793
27	3-Methylglutaconic aciduria (HP:0003535)	2.51970203
28	Tubular atrophy (HP:0000092)	2.50953260
29	Acute encephalopathy (HP:0006846)	2.50336017
30	Increased CSF lactate (HP:0002490)	2.47400726
31	Abolished electroretinogram (ERG) (HP:0000550)	2.41083721
32	Sclerocornea (HP:0000647)	2.36393959
33	Progressive macrocephaly (HP:0004481)	2.31118084
34	Lissencephaly (HP:0001339)	2.30712742
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.27390641
36	Hypothermia (HP:0002045)	2.26343161
37	Hyperventilation (HP:0002883)	2.25903353
38	Decreased central vision (HP:0007663)	2.25125579
39	Methylmalonic aciduria (HP:0012120)	2.24735660
40	Abnormal biliary tract physiology (HP:0012439)	2.24325034
41	Bile duct proliferation (HP:0001408)	2.24325034
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.22660436
43	Polydipsia (HP:0001959)	2.20891406
44	Abnormal drinking behavior (HP:0030082)	2.20891406
45	Optic disc pallor (HP:0000543)	2.15974524
46	Stomach cancer (HP:0012126)	2.15279498
47	Congenital hepatic fibrosis (HP:0002612)	2.15210604
48	Lipid accumulation in hepatocytes (HP:0006561)	2.13843689
49	Increased hepatocellular lipid droplets (HP:0006565)	2.11196101
50	Abnormality of the labia minora (HP:0012880)	2.10489193
51	Birth length less than 3rd percentile (HP:0003561)	2.10413687
52	Hepatocellular necrosis (HP:0001404)	2.07126551
53	Gait imbalance (HP:0002141)	2.04959522
54	Patellar aplasia (HP:0006443)	2.04863034
55	Cerebellar dysplasia (HP:0007033)	2.04577850
56	Poikilocytosis (HP:0004447)	2.03742840
57	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03169338
58	Postaxial foot polydactyly (HP:0001830)	2.02488216
59	Progressive inability to walk (HP:0002505)	2.02239792
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.01242905
61	Absent/shortened dynein arms (HP:0200106)	2.01242905
62	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.01187003
63	Anencephaly (HP:0002323)	2.00808936
64	Hepatic necrosis (HP:0002605)	1.99588590
65	Keratoconus (HP:0000563)	1.99319352
66	Increased corneal curvature (HP:0100692)	1.99319352
67	Congenital primary aphakia (HP:0007707)	1.97039726
68	Aplasia/Hypoplasia of the patella (HP:0006498)	1.94977676
69	Inability to walk (HP:0002540)	1.94597331
70	Pachygyria (HP:0001302)	1.94490261
71	Abnormal number of erythroid precursors (HP:0012131)	1.94059386
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.91040801
73	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91040801
74	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.90507385
75	Hyperglycinuria (HP:0003108)	1.89273795
76	Retinal dysplasia (HP:0007973)	1.88348435
77	Tachypnea (HP:0002789)	1.84738998
78	Optic nerve hypoplasia (HP:0000609)	1.83384568
79	Polyuria (HP:0000103)	1.83353016
80	Furrowed tongue (HP:0000221)	1.82435958
81	Hyperglycinemia (HP:0002154)	1.81302855
82	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80293158
83	Nephrogenic diabetes insipidus (HP:0009806)	1.79523600
84	Increased serum lactate (HP:0002151)	1.79445667
85	Bony spicule pigmentary retinopathy (HP:0007737)	1.78476455
86	Homocystinuria (HP:0002156)	1.78417250
87	Abnormality of homocysteine metabolism (HP:0010919)	1.78417250
88	Abnormality of the ileum (HP:0001549)	1.77687599
89	Meckel diverticulum (HP:0002245)	1.77046411
90	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.74099224
91	Progressive cerebellar ataxia (HP:0002073)	1.72697638
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.70670662
93	Abnormal ciliary motility (HP:0012262)	1.70426874
94	Intestinal atresia (HP:0011100)	1.69857167
95	Preaxial hand polydactyly (HP:0001177)	1.69175499
96	Severe muscular hypotonia (HP:0006829)	1.69160392
97	Occipital encephalocele (HP:0002085)	1.68709768
98	Gaze-evoked nystagmus (HP:0000640)	1.68341184
99	Male pseudohermaphroditism (HP:0000037)	1.68068131
100	Abnormality of DNA repair (HP:0003254)	1.63252909

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.45429898
2	FRK	3.38751167
3	ADRBK2	3.32019169
4	BMPR1B	2.90011127
5	ZAK	2.83522078
6	WNK4	2.69463602
7	TLK1	2.62629076
8	TAOK3	2.35702298
9	NUAK1	2.33910387
10	INSRR	2.29622785
11	GRK1	2.28512446
12	WNK3	2.24873658
13	ACVR1B	2.13482592
14	TXK	2.10541567
15	MAPK13	2.01603955
16	CASK	1.81601472
17	MAP3K4	1.81314288
18	PLK4	1.55879203
19	PINK1	1.52119008
20	DAPK2	1.37393560
21	MKNK2	1.35303754
22	OXSR1	1.33305524
23	MAPK15	1.25414457
24	TGFBR1	1.20351316
25	EIF2AK3	1.18769140
26	EIF2AK1	1.16305414
27	MST4	1.15667696
28	TNIK	1.11114536
29	CLK1	1.10964201
30	NME1	1.04307694
31	MAP2K7	0.98667106
32	DYRK2	0.98628824
33	SRPK1	0.96198104
34	VRK1	0.95121805
35	STK39	0.94308124
36	PLK2	0.93840441
37	PLK3	0.92083120
38	PAK3	0.91695909
39	BRSK2	0.90297767
40	CDK19	0.90041257
41	MARK1	0.88729886
42	MKNK1	0.88593037
43	ADRBK1	0.87934686
44	TRIM28	0.84002764
45	PRKCG	0.82624320
46	RPS6KA5	0.81965111
47	CDC7	0.81787578
48	TSSK6	0.80746505
49	DYRK3	0.80702417
50	NEK2	0.77129485
51	TIE1	0.76628379
52	MUSK	0.76338884
53	PNCK	0.76020150
54	SIK2	0.71663093
55	PASK	0.70832115
56	CAMKK2	0.69119856
57	NTRK2	0.67540321
58	ERBB3	0.67353148
59	SYK	0.67279632
60	CDK8	0.66393121
61	TEC	0.65140464
62	MAP4K1	0.64630537
63	WEE1	0.64384774
64	PRKCI	0.63416413
65	PRKCE	0.63151336
66	BCR	0.62059054
67	NEK1	0.61032556
68	ATR	0.60670371
69	CHEK2	0.58056746
70	CSNK1G1	0.56356563
71	CSNK1G3	0.55859546
72	CSNK1G2	0.55120645
73	IKBKB	0.53664555
74	STK16	0.53627544
75	MARK3	0.53516818
76	PRKCQ	0.52699439
77	STK3	0.52663380
78	TRPM7	0.52301169
79	PHKG1	0.51164019
80	PHKG2	0.51164019
81	AKT3	0.49473546
82	PRKACA	0.48775781
83	IRAK1	0.48742814
84	WNK1	0.48169205
85	NTRK3	0.46964913
86	MAP2K4	0.46485566
87	MAP2K1	0.46360321
88	MAPKAPK5	0.45808751
89	PLK1	0.45559590
90	CSNK1D	0.45159329
91	TNK2	0.43799138
92	ATM	0.42984108
93	MAP2K2	0.41269406
94	LIMK1	0.40796144
95	KIT	0.40273976
96	STK38L	0.40031250
97	CSNK1A1L	0.38733700
98	PTK2B	0.38541693
99	BMPR2	0.38013715
100	CAMK2A	0.37614763

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.73118673
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.55810942
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52708328
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44194526
5	Phototransduction_Homo sapiens_hsa04744	2.43559536
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.40763863
7	Basal transcription factors_Homo sapiens_hsa03022	2.29892128
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.28442814
9	Butanoate metabolism_Homo sapiens_hsa00650	2.27786453
10	Homologous recombination_Homo sapiens_hsa03440	2.19160488
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.16690350
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.09865910
13	Selenocompound metabolism_Homo sapiens_hsa00450	2.05920228
14	Protein export_Homo sapiens_hsa03060	2.03561054
15	Parkinsons disease_Homo sapiens_hsa05012	2.00799119
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.99536973
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.94585088
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.93770826
19	One carbon pool by folate_Homo sapiens_hsa00670	1.91408292
20	Nicotine addiction_Homo sapiens_hsa05033	1.90376278
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.83821354
22	RNA polymerase_Homo sapiens_hsa03020	1.77518323
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.67218698
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.66250761
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.63374403
26	RNA degradation_Homo sapiens_hsa03018	1.62456510
27	Propanoate metabolism_Homo sapiens_hsa00640	1.59108916
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.55888571
29	Caffeine metabolism_Homo sapiens_hsa00232	1.46537774
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.36979071
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32547680
32	Huntingtons disease_Homo sapiens_hsa05016	1.31193145
33	Olfactory transduction_Homo sapiens_hsa04740	1.31120911
34	Taste transduction_Homo sapiens_hsa04742	1.30520309
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25090785
36	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.22896271
37	Peroxisome_Homo sapiens_hsa04146	1.22334841
38	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.18303361
39	Asthma_Homo sapiens_hsa05310	1.17499488
40	Proteasome_Homo sapiens_hsa03050	1.15438703
41	Steroid biosynthesis_Homo sapiens_hsa00100	1.15022209
42	Alzheimers disease_Homo sapiens_hsa05010	1.08160282
43	Ribosome_Homo sapiens_hsa03010	1.04724531
44	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02661955
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01692678
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.01113483
47	ABC transporters_Homo sapiens_hsa02010	0.98421558
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98142158
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.97247721
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96891735
51	Morphine addiction_Homo sapiens_hsa05032	0.94220102
52	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.93432761
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.89316374
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89169631
55	Purine metabolism_Homo sapiens_hsa00230	0.86990181
56	Primary immunodeficiency_Homo sapiens_hsa05340	0.86223379
57	Non-homologous end-joining_Homo sapiens_hsa03450	0.85476705
58	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.83542655
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82703124
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81440096
61	Collecting duct acid secretion_Homo sapiens_hsa04966	0.78243225
62	RNA transport_Homo sapiens_hsa03013	0.76046572
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75834877
64	GABAergic synapse_Homo sapiens_hsa04727	0.75762902
65	Retinol metabolism_Homo sapiens_hsa00830	0.75479928
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74205085
67	Mismatch repair_Homo sapiens_hsa03430	0.72496110
68	Metabolic pathways_Homo sapiens_hsa01100	0.72409636
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.71094645
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70829118
71	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.69848348
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68794973
73	Sulfur metabolism_Homo sapiens_hsa00920	0.68253702
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67762954
75	Serotonergic synapse_Homo sapiens_hsa04726	0.66559824
76	Sulfur relay system_Homo sapiens_hsa04122	0.66370120
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65680452
78	Allograft rejection_Homo sapiens_hsa05330	0.56276219
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.55626347
80	Regulation of autophagy_Homo sapiens_hsa04140	0.54819446
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49362608
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49002015
83	Spliceosome_Homo sapiens_hsa03040	0.48995506
84	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.48269576
85	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47310522
86	Insulin secretion_Homo sapiens_hsa04911	0.46873674
87	Base excision repair_Homo sapiens_hsa03410	0.46524230
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.44728605
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44161435
90	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43746849
91	Graft-versus-host disease_Homo sapiens_hsa05332	0.41025132
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.39910690
93	Circadian entrainment_Homo sapiens_hsa04713	0.38465963
94	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36925325
95	DNA replication_Homo sapiens_hsa03030	0.35589545
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35584622
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.34651804
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.33990280
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.33860293
100	Mineral absorption_Homo sapiens_hsa04978	0.32670736

C17ORF99

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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