C18ORF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.76684903
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.65590436
3chaperone-mediated protein transport (GO:0072321)4.52916101
4chromatin remodeling at centromere (GO:0031055)4.47102734
5ribosomal small subunit assembly (GO:0000028)4.42974276
6CENP-A containing nucleosome assembly (GO:0034080)4.35344269
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.19346575
8ATP synthesis coupled proton transport (GO:0015986)4.11661189
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11661189
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.10426092
11NADH dehydrogenase complex assembly (GO:0010257)4.10426092
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.10426092
13DNA replication checkpoint (GO:0000076)3.90584848
14rRNA modification (GO:0000154)3.85948808
15maturation of SSU-rRNA (GO:0030490)3.79731045
16histone exchange (GO:0043486)3.77218489
17protein complex biogenesis (GO:0070271)3.77110951
18protein K6-linked ubiquitination (GO:0085020)3.75560018
19mitochondrial respiratory chain complex assembly (GO:0033108)3.75364760
20viral transcription (GO:0019083)3.70905551
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.69925907
22translational termination (GO:0006415)3.68336396
23DNA strand elongation involved in DNA replication (GO:0006271)3.64067618
24ribosomal small subunit biogenesis (GO:0042274)3.64066751
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63285980
26ribosomal large subunit biogenesis (GO:0042273)3.61850956
27DNA double-strand break processing (GO:0000729)3.60258599
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.59834198
29protein neddylation (GO:0045116)3.59269272
30telomere maintenance via semi-conservative replication (GO:0032201)3.56154917
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.54053644
32termination of RNA polymerase III transcription (GO:0006386)3.54053644
33pseudouridine synthesis (GO:0001522)3.51822593
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48385144
35DNA strand elongation (GO:0022616)3.48283754
36cullin deneddylation (GO:0010388)3.46463736
37purine nucleobase biosynthetic process (GO:0009113)3.44518079
38respiratory electron transport chain (GO:0022904)3.43630280
39DNA replication-independent nucleosome assembly (GO:0006336)3.39718896
40DNA replication-independent nucleosome organization (GO:0034724)3.39718896
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37251929
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34309173
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34309173
44electron transport chain (GO:0022900)3.33222643
45regulation of mitotic spindle checkpoint (GO:1903504)3.32866987
46regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32866987
47cotranslational protein targeting to membrane (GO:0006613)3.32763169
48protein targeting to mitochondrion (GO:0006626)3.31662067
49spliceosomal snRNP assembly (GO:0000387)3.31637317
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30565884
51protein targeting to ER (GO:0045047)3.30005244
52regulation of mitochondrial translation (GO:0070129)3.29539538
53translational initiation (GO:0006413)3.28489226
54translational elongation (GO:0006414)3.26347303
55cellular component biogenesis (GO:0044085)3.24589700
56translation (GO:0006412)3.23578603
57DNA catabolic process, exonucleolytic (GO:0000738)3.22275416
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.22157420
59anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19909151
60protein deneddylation (GO:0000338)3.17909118
61negative regulation of ligase activity (GO:0051352)3.16937714
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16937714
63mitotic metaphase plate congression (GO:0007080)3.15447478
64respiratory chain complex IV assembly (GO:0008535)3.15286004
65establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15106963
66ribosome assembly (GO:0042255)3.14365560
67rRNA processing (GO:0006364)3.14296918
68protein localization to endoplasmic reticulum (GO:0070972)3.13854225
69protein localization to mitochondrion (GO:0070585)3.13742178
70ribonucleoprotein complex biogenesis (GO:0022613)3.11617887
71DNA replication-dependent nucleosome organization (GO:0034723)3.08975089
72DNA replication-dependent nucleosome assembly (GO:0006335)3.08975089
73rRNA metabolic process (GO:0016072)3.06813955
74establishment of protein localization to mitochondrion (GO:0072655)3.06245526
75mitochondrial RNA metabolic process (GO:0000959)3.06060856
76telomere maintenance via recombination (GO:0000722)3.04850049
77regulation of meiosis I (GO:0060631)3.03931325
78mitotic spindle checkpoint (GO:0071174)3.00259162
79kinetochore assembly (GO:0051382)3.00055389
80kinetochore organization (GO:0051383)2.98020973
81negative regulation of mitotic sister chromatid separation (GO:2000816)2.97345199
82negative regulation of sister chromatid segregation (GO:0033046)2.97345199
83negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97345199
84negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.97345199
85negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97345199
86mitotic recombination (GO:0006312)2.96110688
87nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95604014
88nucleobase biosynthetic process (GO:0046112)2.95284921
89rRNA methylation (GO:0031167)2.95268900
90tRNA processing (GO:0008033)2.93008465
91spindle checkpoint (GO:0031577)2.91677254
92transcription-coupled nucleotide-excision repair (GO:0006283)2.91398561
93formation of translation preinitiation complex (GO:0001731)2.89880383
94negative regulation of chromosome segregation (GO:0051985)2.87909632
95histone mRNA metabolic process (GO:0008334)2.87258728
96oxidative phosphorylation (GO:0006119)2.86834137
97viral life cycle (GO:0019058)2.85572169
98mitotic spindle assembly checkpoint (GO:0007094)2.84929440
99cellular protein complex disassembly (GO:0043624)2.83811610
100tRNA metabolic process (GO:0006399)2.83322831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.10070457
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.44994915
3E2F7_22180533_ChIP-Seq_HELA_Human4.42007356
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.03934839
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.71261844
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.65322769
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.53588187
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30824448
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.24011850
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08125212
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.94678169
12* VDR_23849224_ChIP-Seq_CD4+_Human2.93295881
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90253460
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86645821
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85011988
16ELK1_19687146_ChIP-ChIP_HELA_Human2.69259478
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.68964187
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.59613895
19* FOXP3_21729870_ChIP-Seq_TREG_Human2.55934912
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55586176
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51287691
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46764349
23DCP1A_22483619_ChIP-Seq_HELA_Human2.19803177
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19034782
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18471402
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18173398
27* TTF2_22483619_ChIP-Seq_HELA_Human2.15973934
28* GABP_19822575_ChIP-Seq_HepG2_Human2.11719706
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11701555
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11523084
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08785888
32* XRN2_22483619_ChIP-Seq_HELA_Human2.03389152
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95103757
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92998619
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91285372
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89920076
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89373838
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.89213759
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86388769
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85383483
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82674627
42MYC_18940864_ChIP-ChIP_HL60_Human1.81657327
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78296280
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.73532603
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.69580656
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69177080
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.59642245
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58283129
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.57553675
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.57437134
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49967851
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.47527483
53FUS_26573619_Chip-Seq_HEK293_Human1.47288520
54ZNF274_21170338_ChIP-Seq_K562_Hela1.45766785
55EWS_26573619_Chip-Seq_HEK293_Human1.41830836
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41180418
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38403210
58KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37445031
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30297221
60CIITA_25753668_ChIP-Seq_RAJI_Human1.28890235
61AR_21909140_ChIP-Seq_LNCAP_Human1.28537840
62KDM5A_27292631_Chip-Seq_BREAST_Human1.28404985
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27655447
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.25418610
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22670361
66NANOG_16153702_ChIP-ChIP_HESCs_Human1.22307782
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19539502
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18684992
69SOX2_16153702_ChIP-ChIP_HESCs_Human1.18233368
70IRF1_19129219_ChIP-ChIP_H3396_Human1.17514837
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13459513
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13180008
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12625347
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10502825
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10262858
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10241611
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.10180234
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06897735
79ELK1_22589737_ChIP-Seq_MCF10A_Human1.04229685
80BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01290931
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95676981
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94347492
83VDR_22108803_ChIP-Seq_LS180_Human0.93275150
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.92832111
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92267743
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90364236
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89654917
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86953475
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86470253
90* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85948787
91* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.85665290
92FLI1_27457419_Chip-Seq_LIVER_Mouse0.82590044
93KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80578502
94KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80578502
95KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80578502
96IGF1R_20145208_ChIP-Seq_DFB_Human0.79974803
97* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78705149
98TP53_22573176_ChIP-Seq_HFKS_Human0.78363067
99POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77813040
100TFEB_21752829_ChIP-Seq_HELA_Human0.73880262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair5.02697787
2MP0003693_abnormal_embryo_hatching4.06856236
3MP0010094_abnormal_chromosome_stability3.92548523
4MP0008877_abnormal_DNA_methylation3.61572346
5MP0004957_abnormal_blastocyst_morpholog3.24349020
6MP0003111_abnormal_nucleus_morphology3.14103734
7MP0006292_abnormal_olfactory_placode3.04551937
8MP0003077_abnormal_cell_cycle2.85514426
9MP0008057_abnormal_DNA_replication2.71221941
10MP0002102_abnormal_ear_morphology2.55623056
11MP0003186_abnormal_redox_activity2.51959914
12MP0008932_abnormal_embryonic_tissue2.38077722
13MP0003718_maternal_effect2.23324528
14MP0000372_irregular_coat_pigmentation2.17739088
15MP0006035_abnormal_mitochondrial_morpho2.08890900
16MP0001293_anophthalmia2.02726000
17MP0006036_abnormal_mitochondrial_physio2.01693779
18MP0008007_abnormal_cellular_replicative1.97054289
19MP0003786_premature_aging1.92143000
20MP0009697_abnormal_copulation1.91090816
21MP0002938_white_spotting1.86223861
22MP0009379_abnormal_foot_pigmentation1.79567865
23MP0001764_abnormal_homeostasis1.76425767
24MP0003195_calcinosis1.73697784
25MP0002210_abnormal_sex_determination1.61703498
26MP0002163_abnormal_gland_morphology1.59715899
27MP0003806_abnormal_nucleotide_metabolis1.52295872
28MP0001929_abnormal_gametogenesis1.51753571
29MP0002653_abnormal_ependyma_morphology1.45996272
30MP0008789_abnormal_olfactory_epithelium1.44773728
31MP0001529_abnormal_vocalization1.43618471
32MP0004147_increased_porphyrin_level1.38838356
33MP0000653_abnormal_sex_gland1.38734220
34MP0008995_early_reproductive_senescence1.35758917
35MP0001145_abnormal_male_reproductive1.32527952
36MP0002160_abnormal_reproductive_system1.32315239
37MP0004142_abnormal_muscle_tone1.32107262
38MP0010030_abnormal_orbit_morphology1.32006003
39MP0003567_abnormal_fetal_cardiomyocyte1.31326853
40MP0003787_abnormal_imprinting1.20580185
41MP0000313_abnormal_cell_death1.18437335
42MP0000358_abnormal_cell_content/1.18177925
43MP0003221_abnormal_cardiomyocyte_apopto1.16292349
44MP0003646_muscle_fatigue1.15599315
45MP0005389_reproductive_system_phenotype1.13718218
46MP0001119_abnormal_female_reproductive1.13331936
47MP0001697_abnormal_embryo_size1.12917878
48MP0000350_abnormal_cell_proliferation1.11939546
49MP0000049_abnormal_middle_ear1.11846706
50MP0003121_genomic_imprinting1.10570023
51MP0002132_abnormal_respiratory_system1.10330991
52MP0003698_abnormal_male_reproductive1.08783699
53MP0002090_abnormal_vision1.07600513
54MP0003136_yellow_coat_color1.05658863
55MP0003941_abnormal_skin_development1.00108800
56MP0002822_catalepsy0.99588506
57MP0005646_abnormal_pituitary_gland0.97962811
58MP0002837_dystrophic_cardiac_calcinosis0.95810915
59MP0010307_abnormal_tumor_latency0.95535678
60MP0005645_abnormal_hypothalamus_physiol0.95371608
61MP0002736_abnormal_nociception_after0.94965919
62MP0003937_abnormal_limbs/digits/tail_de0.94928221
63MP0000631_abnormal_neuroendocrine_gland0.93520001
64MP0005380_embryogenesis_phenotype0.93026220
65MP0001672_abnormal_embryogenesis/_devel0.93026220
66MP0005084_abnormal_gallbladder_morpholo0.92553028
67MP0005394_taste/olfaction_phenotype0.92438741
68MP0005499_abnormal_olfactory_system0.92438741
69MP0004133_heterotaxia0.92433773
70MP0001286_abnormal_eye_development0.89216171
71MP0005410_abnormal_fertilization0.88767150
72MP0002234_abnormal_pharynx_morphology0.88469379
73MP0001324_abnormal_eye_pigmentation0.88208681
74MP0005379_endocrine/exocrine_gland_phen0.87260328
75MP0001919_abnormal_reproductive_system0.86645171
76MP0002085_abnormal_embryonic_tissue0.86264744
77MP0002084_abnormal_developmental_patter0.85931593
78MP0002095_abnormal_skin_pigmentation0.85203106
79MP0006276_abnormal_autonomic_nervous0.79231138
80MP0002080_prenatal_lethality0.77518384
81MP0005551_abnormal_eye_electrophysiolog0.77089013
82MP0002277_abnormal_respiratory_mucosa0.76659171
83MP0002751_abnormal_autonomic_nervous0.76157941
84MP0001968_abnormal_touch/_nociception0.75080146
85MP0005187_abnormal_penis_morphology0.73900732
86MP0001853_heart_inflammation0.73597847
87MP0004197_abnormal_fetal_growth/weight/0.71904480
88MP0003984_embryonic_growth_retardation0.71876203
89MP0001730_embryonic_growth_arrest0.71404942
90MP0002019_abnormal_tumor_incidence0.70474861
91MP0000647_abnormal_sebaceous_gland0.70005487
92MP0002088_abnormal_embryonic_growth/wei0.69763400
93MP0002161_abnormal_fertility/fecundity0.69628017
94MP0005408_hypopigmentation0.68561056
95MP0003880_abnormal_central_pattern0.68168781
96MP0002697_abnormal_eye_size0.67124643
97MP0003119_abnormal_digestive_system0.65675664
98MP0006072_abnormal_retinal_apoptosis0.64613072
99MP0001984_abnormal_olfaction0.64213372
100MP0003123_paternal_imprinting0.63864798

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32306703
2Mitochondrial inheritance (HP:0001427)3.99368659
3Increased CSF lactate (HP:0002490)3.91542997
4Abnormal mitochondria in muscle tissue (HP:0008316)3.89934253
5Lipid accumulation in hepatocytes (HP:0006561)3.88387819
6Acute encephalopathy (HP:0006846)3.84930977
7Hepatocellular necrosis (HP:0001404)3.82356757
8Increased hepatocellular lipid droplets (HP:0006565)3.81568765
9Hepatic necrosis (HP:0002605)3.81398347
10Progressive macrocephaly (HP:0004481)3.61413429
11Abnormality of cells of the erythroid lineage (HP:0012130)3.41051641
12Abnormal number of erythroid precursors (HP:0012131)3.34363249
13Colon cancer (HP:0003003)3.10682359
14Cerebral hypomyelination (HP:0006808)3.09742146
15Reticulocytopenia (HP:0001896)3.09559020
16Renal Fanconi syndrome (HP:0001994)3.01526318
17Increased serum lactate (HP:0002151)2.99797061
18Abnormality of the labia minora (HP:0012880)2.95232864
19Cerebral edema (HP:0002181)2.93872837
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.88332313
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.88332313
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87558503
23Pancreatic cysts (HP:0001737)2.80857935
24Increased intramyocellular lipid droplets (HP:0012240)2.74960117
25Lactic acidosis (HP:0003128)2.73398002
26Generalized aminoaciduria (HP:0002909)2.69672017
27Abnormality of alanine metabolism (HP:0010916)2.65096888
28Hyperalaninemia (HP:0003348)2.65096888
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.65096888
30Macrocytic anemia (HP:0001972)2.64097530
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59468997
32Meckel diverticulum (HP:0002245)2.59452679
33Increased serum pyruvate (HP:0003542)2.58282701
34Pancreatic fibrosis (HP:0100732)2.53462501
35Exertional dyspnea (HP:0002875)2.53059341
36Abnormality of the anterior horn cell (HP:0006802)2.47283682
37Degeneration of anterior horn cells (HP:0002398)2.47283682
38Increased muscle lipid content (HP:0009058)2.43856516
39Abnormality of the ileum (HP:0001549)2.43527422
40Aplastic anemia (HP:0001915)2.38900574
41Chromsome breakage (HP:0040012)2.34475814
42CNS demyelination (HP:0007305)2.33669474
43CNS hypomyelination (HP:0003429)2.33390039
44Exercise intolerance (HP:0003546)2.31549751
45Respiratory failure (HP:0002878)2.31504594
46Abnormality of the preputium (HP:0100587)2.30581007
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.28237808
48Abnormality of chromosome stability (HP:0003220)2.23644322
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23175118
50Microvesicular hepatic steatosis (HP:0001414)2.18916847
51Medial flaring of the eyebrow (HP:0010747)2.17976188
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17095947
53Pallor (HP:0000980)2.15774466
54Respiratory difficulties (HP:0002880)2.14386762
55Hyperglycinemia (HP:0002154)2.13303059
56Abnormality of glycolysis (HP:0004366)2.06062130
57Supernumerary spleens (HP:0009799)2.06025563
58Bile duct proliferation (HP:0001408)2.00922487
59Abnormal biliary tract physiology (HP:0012439)2.00922487
60True hermaphroditism (HP:0010459)2.00919536
61Lethargy (HP:0001254)1.96613779
62Abnormal lung lobation (HP:0002101)1.96570618
63Multiple enchondromatosis (HP:0005701)1.95601998
64Emotional lability (HP:0000712)1.95421982
65Leukodystrophy (HP:0002415)1.95072029
66Optic disc pallor (HP:0000543)1.94795704
67Birth length less than 3rd percentile (HP:0003561)1.93552713
68Neoplasm of the adrenal cortex (HP:0100641)1.92665044
69Premature ovarian failure (HP:0008209)1.92150343
70Triphalangeal thumb (HP:0001199)1.91545587
71Medulloblastoma (HP:0002885)1.91513561
72Carpal bone hypoplasia (HP:0001498)1.89954661
73Stenosis of the external auditory canal (HP:0000402)1.89551745
74Abnormal protein glycosylation (HP:0012346)1.88669620
75Abnormal glycosylation (HP:0012345)1.88669620
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88669620
77Abnormal protein N-linked glycosylation (HP:0012347)1.88669620
78Congenital primary aphakia (HP:0007707)1.88659621
79Hypoplastic pelvis (HP:0008839)1.88280880
80Pancytopenia (HP:0001876)1.88260834
81Abnormality of renal resorption (HP:0011038)1.87544226
82Cleft eyelid (HP:0000625)1.87474717
83Abnormality of serum amino acid levels (HP:0003112)1.85434363
843-Methylglutaconic aciduria (HP:0003535)1.84560814
85Absent thumb (HP:0009777)1.83468734
86Duodenal stenosis (HP:0100867)1.83070412
87Small intestinal stenosis (HP:0012848)1.83070412
88Sloping forehead (HP:0000340)1.81493803
89Renal cortical cysts (HP:0000803)1.81146349
90Nausea (HP:0002018)1.78064294
91Postnatal microcephaly (HP:0005484)1.77937085
92Oral leukoplakia (HP:0002745)1.77734606
93Type I transferrin isoform profile (HP:0003642)1.76769701
94Neoplasm of the adrenal gland (HP:0100631)1.76441821
95Constricted visual fields (HP:0001133)1.76300160
96Hypoglycemic coma (HP:0001325)1.74709710
97Nephrogenic diabetes insipidus (HP:0009806)1.73264385
98Gait imbalance (HP:0002141)1.72994218
99Cellular immunodeficiency (HP:0005374)1.71056296
100Unsteady gait (HP:0002317)1.67651924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK14.00539006
2WEE13.51157842
3VRK23.42768025
4BUB13.23290104
5BRSK23.16946092
6STK163.03844527
7CDC72.86099346
8PLK42.78110447
9VRK12.48517981
10ZAK2.42461395
11NEK12.17431454
12TTK2.07570071
13NME22.06923567
14EIF2AK32.06014496
15NUAK11.99964724
16PINK11.96825149
17MKNK11.78959281
18BMPR1B1.76601977
19PLK11.74621522
20DYRK21.68169072
21PLK31.67887407
22NME11.62872807
23BRSK11.59394201
24MKNK21.57490460
25MAP4K21.47346074
26WNK31.45808937
27BCKDK1.43455127
28PBK1.38654856
29TRIM281.37570412
30TLK11.34915515
31TAOK31.34154468
32ERBB31.32778208
33EIF2AK11.22569068
34CHEK21.21457723
35ATR1.18989415
36BCR1.16555902
37ACVR1B1.14922397
38EIF2AK21.14582069
39DYRK31.12567573
40TNIK1.09963621
41MST41.09349417
42GRK71.05811393
43PDK21.05607039
44CSNK1G31.04235075
45CDK191.03480319
46MAP2K71.03035407
47TSSK61.02665118
48CSNK1G10.97523542
49CSNK1G20.97315434
50AURKA0.97235776
51AURKB0.96076951
52PASK0.88820041
53TAF10.88616396
54PNCK0.87148328
55TIE10.85670755
56CSNK1A1L0.81221144
57RPS6KA50.80868753
58GRK10.78821262
59RPS6KA40.75742516
60MAP3K40.75569901
61ATM0.74015411
62ADRBK20.73631296
63CSNK2A10.72060379
64CHEK10.71783398
65TEC0.67612179
66NEK20.65770554
67CDK30.65583022
68PLK20.62581998
69CSNK2A20.62224026
70PIM10.62223138
71LIMK10.57281508
72MAPK130.56438158
73CDK70.56003778
74CCNB10.54372912
75MARK30.51764150
76PRKCG0.50031469
77STK30.49275380
78STK38L0.46633188
79TGFBR10.46435297
80MATK0.45087803
81TESK20.43691914
82BRAF0.43491717
83ABL20.40705153
84MAP3K50.37571153
85CSNK1A10.37178525
86CDK10.36709512
87CDK20.35708984
88KDR0.35447103
89CLK10.34564986
90PKN10.33997152
91STK40.33313645
92WNK40.30888597
93DAPK30.29826163
94PIM20.29349703
95MAPKAPK50.27917105
96CSNK1E0.27260149
97MAP3K80.26031500
98PRKDC0.23400111
99FLT30.22834220
100STK240.22013940

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16371887
2Proteasome_Homo sapiens_hsa030503.69228528
3DNA replication_Homo sapiens_hsa030303.64598521
4Oxidative phosphorylation_Homo sapiens_hsa001903.43456493
5Mismatch repair_Homo sapiens_hsa034303.29290010
6RNA polymerase_Homo sapiens_hsa030203.16690578
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13473600
8Parkinsons disease_Homo sapiens_hsa050123.08421021
9Protein export_Homo sapiens_hsa030602.85675067
10Homologous recombination_Homo sapiens_hsa034402.74923662
11Spliceosome_Homo sapiens_hsa030402.72782572
12RNA transport_Homo sapiens_hsa030132.39238392
13Non-homologous end-joining_Homo sapiens_hsa034502.35637802
14Huntingtons disease_Homo sapiens_hsa050162.28508637
15Nucleotide excision repair_Homo sapiens_hsa034202.26488845
16Fanconi anemia pathway_Homo sapiens_hsa034602.21231941
17Base excision repair_Homo sapiens_hsa034102.08279267
18Basal transcription factors_Homo sapiens_hsa030222.04840768
19RNA degradation_Homo sapiens_hsa030182.02655854
20Pyrimidine metabolism_Homo sapiens_hsa002401.96834254
21Alzheimers disease_Homo sapiens_hsa050101.87446285
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84566681
23One carbon pool by folate_Homo sapiens_hsa006701.83799546
24Cell cycle_Homo sapiens_hsa041101.70698428
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68204426
26Fatty acid elongation_Homo sapiens_hsa000621.50231114
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39286706
28Purine metabolism_Homo sapiens_hsa002301.36240287
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34304546
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32846553
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.29578852
32Propanoate metabolism_Homo sapiens_hsa006401.27334149
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25802293
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18705302
35Folate biosynthesis_Homo sapiens_hsa007901.15412321
36Sulfur relay system_Homo sapiens_hsa041221.08703195
37p53 signaling pathway_Homo sapiens_hsa041151.08202307
38Cardiac muscle contraction_Homo sapiens_hsa042601.07814713
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.06600779
40Selenocompound metabolism_Homo sapiens_hsa004501.02501079
41mRNA surveillance pathway_Homo sapiens_hsa030151.01042036
42Glutathione metabolism_Homo sapiens_hsa004800.97701662
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95664192
44Steroid biosynthesis_Homo sapiens_hsa001000.93798521
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93244188
46Systemic lupus erythematosus_Homo sapiens_hsa053220.92227662
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90065774
48Regulation of autophagy_Homo sapiens_hsa041400.88494340
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77736346
50Pyruvate metabolism_Homo sapiens_hsa006200.75823620
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72772618
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70265539
53Metabolic pathways_Homo sapiens_hsa011000.67919867
54Peroxisome_Homo sapiens_hsa041460.66346471
55Oocyte meiosis_Homo sapiens_hsa041140.64390008
56Epstein-Barr virus infection_Homo sapiens_hsa051690.62721064
57Carbon metabolism_Homo sapiens_hsa012000.48055809
58Alcoholism_Homo sapiens_hsa050340.46779931
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44068197
60Collecting duct acid secretion_Homo sapiens_hsa049660.42513140
61TGF-beta signaling pathway_Homo sapiens_hsa043500.40408041
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40094085
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38593113
64Sulfur metabolism_Homo sapiens_hsa009200.37840073
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.36658489
66beta-Alanine metabolism_Homo sapiens_hsa004100.36384771
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32140000
68Phototransduction_Homo sapiens_hsa047440.31948820
69Nitrogen metabolism_Homo sapiens_hsa009100.30898276
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30667852
71Biosynthesis of amino acids_Homo sapiens_hsa012300.27257918
72Butanoate metabolism_Homo sapiens_hsa006500.27110316
73Viral carcinogenesis_Homo sapiens_hsa052030.26295935
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25938892
75Vitamin B6 metabolism_Homo sapiens_hsa007500.25275883
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.23417485
77Tryptophan metabolism_Homo sapiens_hsa003800.22071027
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21519354
79Legionellosis_Homo sapiens_hsa051340.19137215
80Herpes simplex infection_Homo sapiens_hsa051680.18876089
81Fatty acid metabolism_Homo sapiens_hsa012120.17877577
82Rheumatoid arthritis_Homo sapiens_hsa053230.17341267
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.16326955
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.14994037
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.14735643
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14467415
87Arginine and proline metabolism_Homo sapiens_hsa003300.13612279
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13096856
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13081601
90Primary immunodeficiency_Homo sapiens_hsa053400.12874550
91Basal cell carcinoma_Homo sapiens_hsa052170.12198053
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.11905389
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10948025
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10821704
95Vitamin digestion and absorption_Homo sapiens_hsa049770.08909024
96Fatty acid degradation_Homo sapiens_hsa000710.08179553
97Hedgehog signaling pathway_Homo sapiens_hsa043400.06428775
98Linoleic acid metabolism_Homo sapiens_hsa005910.06251281
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06081279
100Chemical carcinogenesis_Homo sapiens_hsa052040.05076891

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