ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	4.23213794
2	sphingosine metabolic process (GO:0006670)	3.90743412
3	DNA double-strand break processing (GO:0000729)	3.88745983
4	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.78740788
5	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.78740788
6	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.78740788
7	histone H3-K4 trimethylation (GO:0080182)	3.73624202
8	positive regulation of granulocyte differentiation (GO:0030854)	3.62036858
9	neural tube formation (GO:0001841)	3.46235557
10	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.30560622
11	protein K11-linked deubiquitination (GO:0035871)	3.29175682
12	cytoplasmic mRNA processing body assembly (GO:0033962)	3.26123098
13	double-strand break repair via nonhomologous end joining (GO:0006303)	3.25964869
14	non-recombinational repair (GO:0000726)	3.25964869
15	diol metabolic process (GO:0034311)	3.20533230
16	sphingoid metabolic process (GO:0046519)	3.17289887
17	regulation of pigment cell differentiation (GO:0050932)	3.15504285
18	inositol phosphate catabolic process (GO:0071545)	3.15481462
19	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.11572262
20	phosphorylated carbohydrate dephosphorylation (GO:0046838)	3.10188989
21	inositol phosphate dephosphorylation (GO:0046855)	3.10188989
22	histone mRNA catabolic process (GO:0071044)	3.07729944
23	regulation of relaxation of muscle (GO:1901077)	3.06390633
24	establishment of protein localization to Golgi (GO:0072600)	3.03433751
25	kynurenine metabolic process (GO:0070189)	3.03166283
26	activated T cell proliferation (GO:0050798)	2.97348888
27	peptidyl-lysine trimethylation (GO:0018023)	2.95186351
28	mitotic sister chromatid cohesion (GO:0007064)	2.95179130
29	negative regulation of T-helper cell differentiation (GO:0045623)	2.94363603
30	negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)	2.94363603
31	monoubiquitinated protein deubiquitination (GO:0035520)	2.92816481
32	tryptophan catabolic process (GO:0006569)	2.91731245
33	indole-containing compound catabolic process (GO:0042436)	2.91731245
34	indolalkylamine catabolic process (GO:0046218)	2.91731245
35	rRNA catabolic process (GO:0016075)	2.91339078
36	histone H3-K36 demethylation (GO:0070544)	2.90957166
37	nuclear pore organization (GO:0006999)	2.81658422
38	protein targeting to Golgi (GO:0000042)	2.80549575
39	protein K6-linked ubiquitination (GO:0085020)	2.79822265
40	regulation of thymocyte apoptotic process (GO:0070243)	2.71985191
41	regulation of MHC class I biosynthetic process (GO:0045343)	2.67567669
42	nuclear pore complex assembly (GO:0051292)	2.66522960
43	regulation of Rac protein signal transduction (GO:0035020)	2.66395080
44	N-terminal protein amino acid acetylation (GO:0006474)	2.65723966
45	early endosome to late endosome transport (GO:0045022)	2.61234038
46	polyol catabolic process (GO:0046174)	2.58938463
47	histone H2A ubiquitination (GO:0033522)	2.58878154
48	maturation of 5.8S rRNA (GO:0000460)	2.57428615
49	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.56601374
50	negative regulation of cell killing (GO:0031342)	2.56601374
51	regulation of B cell receptor signaling pathway (GO:0050855)	2.52864973
52	tryptophan metabolic process (GO:0006568)	2.52385770
53	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.52190133
54	negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)	2.51963346
55	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.49145513
56	cellular response to ethanol (GO:0071361)	2.47858625
57	snRNA transcription (GO:0009301)	2.47452617
58	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.46283639
59	protein K63-linked deubiquitination (GO:0070536)	2.44879029
60	regulation of protein glycosylation (GO:0060049)	2.43961686
61	hepatocyte apoptotic process (GO:0097284)	2.43148005
62	mitochondrial DNA replication (GO:0006264)	2.42996151
63	peptidyl-lysine methylation (GO:0018022)	2.42457760
64	positive regulation of chromosome segregation (GO:0051984)	2.42329169
65	negative thymic T cell selection (GO:0045060)	2.41515098
66	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.40870205
67	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.40870205
68	microtubule anchoring (GO:0034453)	2.39904402
69	protein polyglutamylation (GO:0018095)	2.39119354
70	positive regulation of mRNA catabolic process (GO:0061014)	2.38680163
71	positive regulation of gamma-delta T cell activation (GO:0046645)	2.38596399
72	interferon-gamma production (GO:0032609)	2.37671230
73	regulation of energy homeostasis (GO:2000505)	2.37148784
74	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.36736972
75	developmental pigmentation (GO:0048066)	2.35236322
76	negative T cell selection (GO:0043383)	2.34154683
77	regulation of DNA endoreduplication (GO:0032875)	2.34119094
78	fucose catabolic process (GO:0019317)	2.33591929
79	L-fucose metabolic process (GO:0042354)	2.33591929
80	L-fucose catabolic process (GO:0042355)	2.33591929
81	DNA methylation involved in gamete generation (GO:0043046)	2.33512433
82	piRNA metabolic process (GO:0034587)	2.33056547
83	interkinetic nuclear migration (GO:0022027)	2.32338041
84	natural killer cell activation involved in immune response (GO:0002323)	2.31827567
85	protein K48-linked deubiquitination (GO:0071108)	2.28082198
86	regulation of transforming growth factor beta2 production (GO:0032909)	2.27937689
87	positive regulation of histone H3-K4 methylation (GO:0051571)	2.27838414
88	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.24947669
89	neutrophil mediated immunity (GO:0002446)	2.24769359
90	positive T cell selection (GO:0043368)	2.24085924
91	regulation of interferon-beta biosynthetic process (GO:0045357)	2.23260302
92	negative regulation of T cell mediated immunity (GO:0002710)	2.23208644
93	germinal center formation (GO:0002467)	2.22967135
94	negative regulation of neurotransmitter transport (GO:0051589)	2.20703393
95	T cell homeostasis (GO:0043029)	2.19648995
96	negative regulation of thymocyte apoptotic process (GO:0070244)	2.19199759
97	histone H4-K16 acetylation (GO:0043984)	2.18799059
98	regulation of mRNA catabolic process (GO:0061013)	2.17579485
99	transcription from mitochondrial promoter (GO:0006390)	2.17532741
100	positive regulation of organelle assembly (GO:1902117)	2.16649261

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.69418711
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.62862240
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.80700922
4	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75091585
5	* POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.71948084
6	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.61930338
7	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.61528604
8	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.44722500
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.40410133
10	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.35288158
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.21065263
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10344580
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.09400358
14	GBX2_23144817_ChIP-Seq_PC3_Human	2.06958879
15	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.99601515
16	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.98169935
17	FUS_26573619_Chip-Seq_HEK293_Human	1.85678704
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.81585554
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.75828084
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75538649
21	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.74345436
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68828323
23	EWS_26573619_Chip-Seq_HEK293_Human	1.63166794
24	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.62517427
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.60547087
26	P300_19829295_ChIP-Seq_ESCs_Human	1.60242757
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58462205
28	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.56701017
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.52033791
30	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51553042
31	STAT3_23295773_ChIP-Seq_U87_Human	1.48726282
32	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.45618028
33	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.43838572
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.43570631
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.42429191
36	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37826884
37	RUNX_20019798_ChIP-Seq_JUKART_Human	1.37801164
38	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37537867
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36363120
40	CBP_20019798_ChIP-Seq_JUKART_Human	1.36324752
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36324752
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36232921
43	GATA3_26560356_Chip-Seq_TH2_Human	1.36138988
44	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35460759
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.34700444
46	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.34493627
47	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.33614353
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.33519490
49	VDR_22108803_ChIP-Seq_LS180_Human	1.33331798
50	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32998081
51	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.32769108
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.32508365
53	TCF4_23295773_ChIP-Seq_U87_Human	1.32494805
54	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.31594330
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31395740
56	* MYB_26560356_Chip-Seq_TH2_Human	1.30012368
57	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.26478169
58	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.26138880
59	* RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.25034729
60	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23909285
61	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.22873973
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22413637
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22413637
64	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21953391
65	* AR_25329375_ChIP-Seq_VCAP_Human	1.21152994
66	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.18764914
67	* CDX2_22108803_ChIP-Seq_LS180_Human	1.17809514
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17350949
69	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.17102002
70	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.17050512
71	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.15434713
72	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.14945323
73	* BRD4_25478319_ChIP-Seq_HGPS_Human	1.14273753
74	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13719682
75	* PRDM14_20953172_ChIP-Seq_ESCs_Human	1.11995968
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11916534
77	GATA1_22025678_ChIP-Seq_K562_Human	1.11774978
78	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.11591399
79	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11095964
80	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.11067413
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10000471
82	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.09943449
83	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08894874
84	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.08141933
85	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.07025660
86	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.06316304
87	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.06316304
88	TCF4_22108803_ChIP-Seq_LS180_Human	1.06092823
89	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.05132079
90	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04097391
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03064565
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02841811
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01804261
94	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.00397695
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99504035
96	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.99456376
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.99361862
98	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.99343742
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.99103393
100	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.97943278

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	3.65612109
2	MP0002837_dystrophic_cardiac_calcinosis	3.57863858
3	MP0008877_abnormal_DNA_methylation	3.37991142
4	MP0002009_preneoplasia	3.05372376
5	MP0000569_abnormal_digit_pigmentation	3.00805928
6	MP0008057_abnormal_DNA_replication	2.94362618
7	MP0003787_abnormal_imprinting	2.78284758
8	MP0004084_abnormal_cardiac_muscle	2.73643327
9	MP0004381_abnormal_hair_follicle	2.65715847
10	MP0010352_gastrointestinal_tract_polyps	2.61175208
11	MP0003763_abnormal_thymus_physiology	2.35546732
12	MP0010234_abnormal_vibrissa_follicle	2.28652376
13	MP0004484_altered_response_of	2.26149757
14	MP0003890_abnormal_embryonic-extraembry	2.15989733
15	MP0004215_abnormal_myocardial_fiber	2.14607443
16	MP0002166_altered_tumor_susceptibility	2.12071993
17	MP0003828_pulmonary_edema	2.03577769
18	MP0000427_abnormal_hair_cycle	1.98947677
19	MP0003950_abnormal_plasma_membrane	1.97098647
20	MP0008775_abnormal_heart_ventricle	1.96224657
21	MP0000015_abnormal_ear_pigmentation	1.94382525
22	MP0004036_abnormal_muscle_relaxation	1.90366264
23	MP0005075_abnormal_melanosome_morpholog	1.88335932
24	MP0002102_abnormal_ear_morphology	1.83899023
25	MP0000749_muscle_degeneration	1.82822835
26	MP0003724_increased_susceptibility_to	1.77312549
27	MP0002332_abnormal_exercise_endurance	1.73023015
28	MP0005174_abnormal_tail_pigmentation	1.68135232
29	MP0000372_irregular_coat_pigmentation	1.67877387
30	MP0010094_abnormal_chromosome_stability	1.67546379
31	MP0003045_fibrosis	1.66809634
32	MP0002006_tumorigenesis	1.64417675
33	MP0002396_abnormal_hematopoietic_system	1.60135013
34	MP0008058_abnormal_DNA_repair	1.57884413
35	MP0004130_abnormal_muscle_cell	1.55352961
36	MP0002138_abnormal_hepatobiliary_system	1.53326068
37	MP0003221_abnormal_cardiomyocyte_apopto	1.44416312
38	MP0004145_abnormal_muscle_electrophysio	1.40345776
39	MP0001800_abnormal_humoral_immune	1.37211666
40	MP0001835_abnormal_antigen_presentation	1.32732135
41	MP0002163_abnormal_gland_morphology	1.32665987
42	MP0005310_abnormal_salivary_gland	1.29481651
43	MP0006082_CNS_inflammation	1.28579298
44	MP0005620_abnormal_muscle_contractility	1.25526623
45	MP0010678_abnormal_skin_adnexa	1.24274438
46	MP0002972_abnormal_cardiac_muscle	1.21214899
47	MP0004808_abnormal_hematopoietic_stem	1.20466987
48	MP0002160_abnormal_reproductive_system	1.09871874
49	MP0000703_abnormal_thymus_morphology	1.09406943
50	MP0000685_abnormal_immune_system	1.08675157
51	MP0002254_reproductive_system_inflammat	1.05473682
52	MP0005266_abnormal_metabolism	1.00712421
53	MP0001544_abnormal_cardiovascular_syste	0.98253091
54	MP0005385_cardiovascular_system_phenoty	0.98253091
55	MP0005171_absent_coat_pigmentation	0.97850967
56	MP0006054_spinal_hemorrhage	0.96962299
57	MP0003656_abnormal_erythrocyte_physiolo	0.96603623
58	MP0000689_abnormal_spleen_morphology	0.96417226
59	MP0008961_abnormal_basal_metabolism	0.96100142
60	MP0002723_abnormal_immune_serum	0.93626928
61	MP0002452_abnormal_antigen_presenting	0.93620848
62	MP0001986_abnormal_taste_sensitivity	0.93362857
63	MP0002269_muscular_atrophy	0.92388815
64	MP0002420_abnormal_adaptive_immunity	0.92352024
65	MP0005253_abnormal_eye_physiology	0.90910792
66	MP0001819_abnormal_immune_cell	0.90868549
67	MP0001984_abnormal_olfaction	0.90133274
68	MP0001188_hyperpigmentation	0.89641574
69	MP0005389_reproductive_system_phenotype	0.88637505
70	MP0002398_abnormal_bone_marrow	0.88336895
71	MP0008875_abnormal_xenobiotic_pharmacok	0.87575300
72	MP0006138_congestive_heart_failure	0.87519330
73	MP0002405_respiratory_system_inflammati	0.86058308
74	MP0003136_yellow_coat_color	0.84649597
75	MP0003195_calcinosis	0.81831778
76	MP0002168_other_aberrant_phenotype	0.80758873
77	MP0005220_abnormal_exocrine_pancreas	0.79928980
78	MP0002928_abnormal_bile_duct	0.79187091
79	MP0002095_abnormal_skin_pigmentation	0.79122365
80	MP0001661_extended_life_span	0.78271949
81	MP0005387_immune_system_phenotype	0.78269745
82	MP0001790_abnormal_immune_system	0.78269745
83	MP0002277_abnormal_respiratory_mucosa	0.77437655
84	MP0000371_diluted_coat_color	0.77422116
85	MP0005379_endocrine/exocrine_gland_phen	0.77066777
86	MP0005330_cardiomyopathy	0.76448640
87	MP0002106_abnormal_muscle_physiology	0.75791363
88	MP0000716_abnormal_immune_system	0.75268297
89	MP0005671_abnormal_response_to	0.75020433
90	MP0003252_abnormal_bile_duct	0.73411425
91	MP0002722_abnormal_immune_system	0.73353591
92	MP0004043_abnormal_pH_regulation	0.72901638
93	MP0004087_abnormal_muscle_fiber	0.72892031
94	MP0003303_peritoneal_inflammation	0.71664939
95	MP0005000_abnormal_immune_tolerance	0.70805560
96	MP0009785_altered_susceptibility_to	0.67654584
97	MP0010307_abnormal_tumor_latency	0.66720516
98	MP0002419_abnormal_innate_immunity	0.65625074
99	MP0006072_abnormal_retinal_apoptosis	0.65576822
100	MP0000383_abnormal_hair_follicle	0.64963436

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	3.62179243
2	Abnormality of the left ventricular outflow tract (HP:0011103)	3.41335188
3	Subaortic stenosis (HP:0001682)	3.41335188
4	Hyporeflexia of lower limbs (HP:0002600)	3.22682615
5	Neoplasm of the adrenal cortex (HP:0100641)	3.14447804
6	Hematochezia (HP:0002573)	2.83969598
7	Pancreatic cysts (HP:0001737)	2.83437648
8	Calf muscle hypertrophy (HP:0008981)	2.82945458
9	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.82844685
10	Volvulus (HP:0002580)	2.77006168
11	Cutaneous melanoma (HP:0012056)	2.75791850
12	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	2.72201466
13	Adactyly (HP:0009776)	2.71636758
14	Muscle fiber inclusion bodies (HP:0100299)	2.71566637
15	Nemaline bodies (HP:0003798)	2.65176451
16	Progressive inability to walk (HP:0002505)	2.64362744
17	Muscle hypertrophy of the lower extremities (HP:0008968)	2.53874072
18	Curly hair (HP:0002212)	2.51877739
19	Areflexia of lower limbs (HP:0002522)	2.43529936
20	Gonadotropin excess (HP:0000837)	2.38634898
21	Abnormal spermatogenesis (HP:0008669)	2.38397296
22	Azoospermia (HP:0000027)	2.37391926
23	Biliary tract neoplasm (HP:0100574)	2.36159134
24	Autoimmune hemolytic anemia (HP:0001890)	2.34638920
25	Widely spaced teeth (HP:0000687)	2.32837339
26	Abnormality of T cell number (HP:0011839)	2.32738610
27	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.29244223
28	Fair hair (HP:0002286)	2.25850490
29	Stomach cancer (HP:0012126)	2.24887664
30	Abnormality of the renal cortex (HP:0011035)	2.22140148
31	Hypoplastic iliac wings (HP:0002866)	2.21036791
32	Abnormality of the columella (HP:0009929)	2.20944300
33	Eosinophilia (HP:0001880)	2.15203845
34	Generalized hypopigmentation of hair (HP:0011358)	2.12751608
35	Abnormal biliary tract physiology (HP:0012439)	2.11953048
36	Bile duct proliferation (HP:0001408)	2.11953048
37	Thyroiditis (HP:0100646)	2.11705204
38	Abnormality of chromosome stability (HP:0003220)	2.10161928
39	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10105098
40	Hypoplasia of the fovea (HP:0007750)	2.10105098
41	Clubbing of toes (HP:0100760)	2.09703446
42	Cystic hygroma (HP:0000476)	2.06801226
43	Prostate neoplasm (HP:0100787)	2.05580817
44	Fibular aplasia (HP:0002990)	2.04060742
45	Rimmed vacuoles (HP:0003805)	2.02476953
46	T lymphocytopenia (HP:0005403)	1.99500385
47	Inability to walk (HP:0002540)	1.95855418
48	Chromsome breakage (HP:0040012)	1.95367306
49	Abnormal biliary tract morphology (HP:0012440)	1.93650831
50	Recurrent cutaneous fungal infections (HP:0011370)	1.92544696
51	Chronic mucocutaneous candidiasis (HP:0002728)	1.92544696
52	Gaze-evoked nystagmus (HP:0000640)	1.92174892
53	Abnormality of the calf musculature (HP:0001430)	1.91180047
54	Febrile seizures (HP:0002373)	1.91083497
55	Tubular atrophy (HP:0000092)	1.89291790
56	Exercise-induced muscle cramps (HP:0003710)	1.87651877
57	Aqueductal stenosis (HP:0002410)	1.85103937
58	Hyperventilation (HP:0002883)	1.83365173
59	Pancreatic fibrosis (HP:0100732)	1.83177470
60	Retrobulbar optic neuritis (HP:0100654)	1.82788182
61	Optic neuritis (HP:0100653)	1.82788182
62	Subacute progressive viral hepatitis (HP:0006572)	1.82090732
63	Keratoconjunctivitis (HP:0001096)	1.80933948
64	Ependymoma (HP:0002888)	1.80725305
65	Frequent falls (HP:0002359)	1.80483851
66	Abnormality of the fovea (HP:0000493)	1.80333892
67	Prominent nose (HP:0000448)	1.79575214
68	Hypochromic microcytic anemia (HP:0004840)	1.79448593
69	Thickened calvaria (HP:0002684)	1.78996785
70	Molar tooth sign on MRI (HP:0002419)	1.76033130
71	Abnormality of midbrain morphology (HP:0002418)	1.76033130
72	Acute lymphatic leukemia (HP:0006721)	1.75892597
73	Panhypogammaglobulinemia (HP:0003139)	1.73127317
74	Medial flaring of the eyebrow (HP:0010747)	1.72191632
75	Aplasia/Hypoplasia of the macula (HP:0008059)	1.71322385
76	Acute myeloid leukemia (HP:0004808)	1.71268349
77	Recurrent fungal infections (HP:0002841)	1.70904208
78	Neoplasm of the small intestine (HP:0100833)	1.70664390
79	2-3 toe syndactyly (HP:0004691)	1.70442966
80	Proximal amyotrophy (HP:0007126)	1.70073206
81	Neonatal hypoglycemia (HP:0001998)	1.68274875
82	Breast carcinoma (HP:0003002)	1.65507741
83	Duplicated collecting system (HP:0000081)	1.64817774
84	Dialeptic seizures (HP:0011146)	1.64792229
85	Abnormality of eosinophils (HP:0001879)	1.64602109
86	Muscle fiber splitting (HP:0003555)	1.64514382
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.62749010
88	Abnormality of T cell physiology (HP:0011840)	1.62574156
89	Nephroblastoma (Wilms tumor) (HP:0002667)	1.62386143
90	Atonic seizures (HP:0010819)	1.62133453
91	Glioma (HP:0009733)	1.62081486
92	Abnormality of B cell number (HP:0010975)	1.62044009
93	Bundle branch block (HP:0011710)	1.61957685
94	Hypochromic anemia (HP:0001931)	1.61772722
95	Sensory axonal neuropathy (HP:0003390)	1.59792999
96	Muscle fibrillation (HP:0010546)	1.59566032
97	IgM deficiency (HP:0002850)	1.59455576
98	Cerebellar dysplasia (HP:0007033)	1.58219525
99	Papillary thyroid carcinoma (HP:0002895)	1.57369967
100	Abnormality of the axillary hair (HP:0100134)	1.56827802

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.87178239
2	EIF2AK3	3.59441219
3	NUAK1	2.67618627
4	OBSCN	2.61258517
5	TRIM28	2.52679576
6	TAOK3	2.40295554
7	NLK	2.38787629
8	BMPR1B	2.31061654
9	STK38L	2.12792134
10	ACVR1B	2.08616807
11	BRD4	2.02401852
12	MKNK2	2.01803123
13	MARK3	1.94827632
14	ERBB3	1.86402009
15	TRPM7	1.81209835
16	AKT3	1.70514520
17	ZAK	1.68059310
18	TEC	1.64920787
19	EIF2AK1	1.62225462
20	SIK3	1.60979606
21	BRSK2	1.46337555
22	MELK	1.44610089
23	STK3	1.42659566
24	LATS1	1.40674077
25	PINK1	1.31195027
26	RPS6KA4	1.27706573
27	MST4	1.19134137
28	EIF2AK2	1.18678756
29	FGFR2	1.12508639
30	MAP3K13	1.11372424
31	TXK	1.09308795
32	ITK	1.05807366
33	STK11	1.01731988
34	SGK2	1.01034698
35	PIK3CA	1.00613576
36	MAP3K14	0.99594795
37	KSR1	0.94289566
38	FGFR3	0.93341897
39	FER	0.92806441
40	TGFBR2	0.90898217
41	MAPK13	0.90867603
42	CDK3	0.89295240
43	MAP3K4	0.88309996
44	MKNK1	0.88247365
45	RAF1	0.84364094
46	PIK3CG	0.81820221
47	BMPR2	0.81666209
48	WNK3	0.81550030
49	HCK	0.81482623
50	MAP4K2	0.79408667
51	STK10	0.78416043
52	PLK3	0.78168817
53	TGFBR1	0.76795397
54	PAK3	0.74925051
55	IRAK1	0.71511009
56	NEK6	0.71293317
57	OXSR1	0.70727673
58	SGK3	0.67193284
59	PRKCQ	0.67037444
60	PLK2	0.66895633
61	JAK1	0.66779121
62	PRKAA2	0.65891296
63	FES	0.65556010
64	BTK	0.62822329
65	SGK223	0.58202277
66	SGK494	0.58202277
67	IKBKE	0.57999287
68	ADRBK2	0.56888139
69	WEE1	0.54714680
70	PHKG1	0.52733850
71	PHKG2	0.52733850
72	YES1	0.51460542
73	TNK2	0.50101532
74	MAP2K3	0.48951744
75	JAK2	0.44313709
76	SYK	0.43321975
77	CDK6	0.43053721
78	BLK	0.42432435
79	TAF1	0.41919642
80	ATM	0.41357710
81	DMPK	0.40154457
82	CAMKK2	0.40017142
83	RPS6KA5	0.39681050
84	RPS6KB1	0.38646447
85	CSK	0.38596636
86	IRAK4	0.37975749
87	BCR	0.37876403
88	ZAP70	0.37140387
89	MAP3K10	0.35500737
90	IRAK2	0.34858667
91	PBK	0.33736189
92	IKBKB	0.33257350
93	CAMK4	0.32606497
94	PRKCE	0.31135459
95	MAP3K6	0.28252438
96	DYRK3	0.28175222
97	FGR	0.27989579
98	MAP3K5	0.27192966
99	MAP4K1	0.26812398
100	ABL1	0.25937332

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	5.15129148
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.37454328
3	Non-homologous end-joining_Homo sapiens_hsa03450	2.15645693
4	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.78295319
5	FoxO signaling pathway_Homo sapiens_hsa04068	1.71305771
6	RNA degradation_Homo sapiens_hsa03018	1.66973247
7	Sphingolipid metabolism_Homo sapiens_hsa00600	1.53468106
8	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.51559496
9	Basal transcription factors_Homo sapiens_hsa03022	1.51537571
10	Circadian rhythm_Homo sapiens_hsa04710	1.49905802
11	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.49763851
12	Regulation of autophagy_Homo sapiens_hsa04140	1.48133566
13	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.45312767
14	Measles_Homo sapiens_hsa05162	1.43575662
15	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.41634761
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39007630
17	p53 signaling pathway_Homo sapiens_hsa04115	1.33755246
18	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.33466873
19	Phototransduction_Homo sapiens_hsa04744	1.21497760
20	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.18400291
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18004681
22	Lysine degradation_Homo sapiens_hsa00310	1.17236249
23	Osteoclast differentiation_Homo sapiens_hsa04380	1.16771123
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.14543902
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.14319591
26	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.12623258
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.10939096
28	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.08351211
29	mTOR signaling pathway_Homo sapiens_hsa04150	1.05454809
30	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.02040300
31	Hepatitis B_Homo sapiens_hsa05161	1.01176229
32	Prostate cancer_Homo sapiens_hsa05215	0.98164148
33	Insulin resistance_Homo sapiens_hsa04931	0.97666043
34	Taste transduction_Homo sapiens_hsa04742	0.97304473
35	Long-term depression_Homo sapiens_hsa04730	0.93050902
36	Endometrial cancer_Homo sapiens_hsa05213	0.92403445
37	Legionellosis_Homo sapiens_hsa05134	0.91453633
38	Non-small cell lung cancer_Homo sapiens_hsa05223	0.91395409
39	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.90577887
40	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.90282010
41	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.89565601
42	African trypanosomiasis_Homo sapiens_hsa05143	0.89560056
43	Prolactin signaling pathway_Homo sapiens_hsa04917	0.89500912
44	Olfactory transduction_Homo sapiens_hsa04740	0.88804727
45	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.88688871
46	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.88480609
47	Herpes simplex infection_Homo sapiens_hsa05168	0.88246901
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.88122516
49	TNF signaling pathway_Homo sapiens_hsa04668	0.86997617
50	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.86644021
51	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.84016224
52	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83433009
53	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.83372234
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.80494929
55	Acute myeloid leukemia_Homo sapiens_hsa05221	0.79307851
56	Platelet activation_Homo sapiens_hsa04611	0.75555086
57	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.74420328
58	Colorectal cancer_Homo sapiens_hsa05210	0.74322813
59	Calcium signaling pathway_Homo sapiens_hsa04020	0.73812712
60	Renin secretion_Homo sapiens_hsa04924	0.72184137
61	Oocyte meiosis_Homo sapiens_hsa04114	0.71365348
62	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.71279470
63	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.71003903
64	RNA transport_Homo sapiens_hsa03013	0.70780255
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.68074962
66	Tuberculosis_Homo sapiens_hsa05152	0.67892213
67	Influenza A_Homo sapiens_hsa05164	0.67262143
68	Insulin signaling pathway_Homo sapiens_hsa04910	0.67208427
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.67205893
70	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.65586465
71	Homologous recombination_Homo sapiens_hsa03440	0.65560310
72	Thyroid cancer_Homo sapiens_hsa05216	0.65470903
73	Glucagon signaling pathway_Homo sapiens_hsa04922	0.65085549
74	Chemokine signaling pathway_Homo sapiens_hsa04062	0.64766960
75	Leishmaniasis_Homo sapiens_hsa05140	0.64527164
76	Salivary secretion_Homo sapiens_hsa04970	0.63582125
77	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.61925791
78	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61840153
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60287456
80	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59921313
81	Tryptophan metabolism_Homo sapiens_hsa00380	0.59262936
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.59168738
83	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.57055462
84	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.56968854
85	Cell cycle_Homo sapiens_hsa04110	0.56736254
86	Pancreatic cancer_Homo sapiens_hsa05212	0.55927560
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.55108497
88	Viral carcinogenesis_Homo sapiens_hsa05203	0.54804303
89	Adherens junction_Homo sapiens_hsa04520	0.54113109
90	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.52801141
91	MicroRNAs in cancer_Homo sapiens_hsa05206	0.52424865
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52022495
93	MAPK signaling pathway_Homo sapiens_hsa04010	0.51865493
94	Glioma_Homo sapiens_hsa05214	0.51231030
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.50810465
96	Morphine addiction_Homo sapiens_hsa05032	0.49216137
97	Hepatitis C_Homo sapiens_hsa05160	0.47925068
98	One carbon pool by folate_Homo sapiens_hsa00670	0.46465197
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.45478060
100	Long-term potentiation_Homo sapiens_hsa04720	0.44495347

C18ORF25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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