ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	5.11324404
2	nucleobase catabolic process (GO:0046113)	4.31252781
3	neuron cell-cell adhesion (GO:0007158)	4.30394785
4	gamma-aminobutyric acid transport (GO:0015812)	4.27916545
5	protein localization to cilium (GO:0061512)	4.04348054
6	presynaptic membrane assembly (GO:0097105)	4.03401033
7	presynaptic membrane organization (GO:0097090)	3.88823047
8	behavioral response to nicotine (GO:0035095)	3.80824949
9	postsynaptic membrane organization (GO:0001941)	3.77440164
10	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.73165452
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.58411254
12	regulation of synapse structural plasticity (GO:0051823)	3.57074445
13	vocalization behavior (GO:0071625)	3.49723448
14	synapse assembly (GO:0007416)	3.49501164
15	positive regulation of mitochondrial fission (GO:0090141)	3.48653123
16	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.45156927
17	auditory behavior (GO:0031223)	3.34189302
18	synaptic vesicle maturation (GO:0016188)	3.32566503
19	nonmotile primary cilium assembly (GO:0035058)	3.32342294
20	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.30407540
21	synaptic vesicle exocytosis (GO:0016079)	3.28531544
22	glycosphingolipid biosynthetic process (GO:0006688)	3.28015189
23	protein localization to synapse (GO:0035418)	3.26788480
24	synaptic transmission, glutamatergic (GO:0035249)	3.25823013
25	glutamate receptor signaling pathway (GO:0007215)	3.20499826
26	sequestering of actin monomers (GO:0042989)	3.19838270
27	neuronal action potential propagation (GO:0019227)	3.19604972
28	epithelial cilium movement (GO:0003351)	3.13730799
29	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.09556155
30	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.09074961
31	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07996980
32	regulation of synaptic vesicle exocytosis (GO:2000300)	3.05236079
33	glutamate secretion (GO:0014047)	3.02654549
34	neurotransmitter-gated ion channel clustering (GO:0072578)	3.00509425
35	platelet dense granule organization (GO:0060155)	2.99575051
36	neuron-neuron synaptic transmission (GO:0007270)	2.97321526
37	transmission of nerve impulse (GO:0019226)	2.97118571
38	neurotransmitter secretion (GO:0007269)	2.92605917
39	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.91022378
40	regulation of synaptic vesicle transport (GO:1902803)	2.90532365
41	axonal fasciculation (GO:0007413)	2.88557264
42	regulation of cilium movement (GO:0003352)	2.88122195
43	dendritic spine morphogenesis (GO:0060997)	2.87996737
44	startle response (GO:0001964)	2.87236427
45	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.84256079
46	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.82726472
47	response to auditory stimulus (GO:0010996)	2.81379382
48	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.79140473
49	regulation of respiratory system process (GO:0044065)	2.77751331
50	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.74156530
51	cilium movement (GO:0003341)	2.73591076
52	neuron recognition (GO:0008038)	2.72539285
53	establishment of mitochondrion localization (GO:0051654)	2.72241379
54	regulation of feeding behavior (GO:0060259)	2.70843010
55	neuronal action potential (GO:0019228)	2.70024527
56	axoneme assembly (GO:0035082)	2.69847427
57	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.68727473
58	cilium or flagellum-dependent cell motility (GO:0001539)	2.67059550
59	C4-dicarboxylate transport (GO:0015740)	2.65253225
60	neuromuscular synaptic transmission (GO:0007274)	2.65042426
61	cellular ketone body metabolic process (GO:0046950)	2.63174176
62	regulation of neurotransmitter levels (GO:0001505)	2.62862530
63	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.62108758
64	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.62108758
65	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.61746530
66	positive regulation of synapse assembly (GO:0051965)	2.58940768
67	regulation of action potential (GO:0098900)	2.58341800
68	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.56785696
69	mechanosensory behavior (GO:0007638)	2.55057947
70	cilium morphogenesis (GO:0060271)	2.54767560
71	cilium assembly (GO:0042384)	2.52812978
72	neural tube formation (GO:0001841)	2.52285617
73	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.52091813
74	cilium organization (GO:0044782)	2.51938879
75	response to dietary excess (GO:0002021)	2.51502483
76	synapse organization (GO:0050808)	2.51202992
77	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.50957841
78	synaptic transmission, cholinergic (GO:0007271)	2.49971201
79	detection of light stimulus involved in visual perception (GO:0050908)	2.49628203
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.49628203
81	glycerophospholipid catabolic process (GO:0046475)	2.49616818
82	proline transport (GO:0015824)	2.47637201
83	intraciliary transport (GO:0042073)	2.47541464
84	regulation of neurotransmitter uptake (GO:0051580)	2.47495464
85	protein neddylation (GO:0045116)	2.47249559
86	membrane depolarization during action potential (GO:0086010)	2.46285328
87	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.43860849
88	ATP hydrolysis coupled proton transport (GO:0015991)	2.43860849
89	protein-cofactor linkage (GO:0018065)	2.42656689
90	adult walking behavior (GO:0007628)	2.42203218
91	regulation of collateral sprouting (GO:0048670)	2.41069679
92	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.40540468
93	neurotransmitter metabolic process (GO:0042133)	2.40400829
94	retinal ganglion cell axon guidance (GO:0031290)	2.40275017
95	positive regulation of amino acid transport (GO:0051957)	2.39778952
96	serotonin metabolic process (GO:0042428)	2.39362595
97	adult behavior (GO:0030534)	2.38802635
98	retinal cone cell development (GO:0046549)	2.38564843
99	regulation of neurotransmitter transport (GO:0051588)	2.38272391
100	axon ensheathment in central nervous system (GO:0032291)	2.37581152

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.29533688
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.39287628
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95123008
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.76338267
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.75806381
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69796674
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.69301786
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.65939742
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46494236
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.41150631
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.39742761
12	VDR_22108803_ChIP-Seq_LS180_Human	2.21763280
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09474823
14	REST_21632747_ChIP-Seq_MESCs_Mouse	2.07936984
15	P300_19829295_ChIP-Seq_ESCs_Human	1.96368902
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88279867
17	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.84354781
18	FUS_26573619_Chip-Seq_HEK293_Human	1.83835389
19	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.80338412
20	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.76786163
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.74948896
22	EWS_26573619_Chip-Seq_HEK293_Human	1.73506739
23	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.73129209
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.67041606
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66274726
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.66110395
27	RNF2_27304074_Chip-Seq_NSC_Mouse	1.63668150
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60490053
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.59774930
30	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.58716019
31	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58194628
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.54301745
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51233750
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.48850378
35	AR_25329375_ChIP-Seq_VCAP_Human	1.48217614
36	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.48150494
37	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44318440
38	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.43938725
39	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.43682093
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.43363693
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41435296
42	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41007365
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40838501
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40744135
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39153563
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.38062072
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38062072
48	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.37866400
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.36344945
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33666706
51	STAT3_23295773_ChIP-Seq_U87_Human	1.32561341
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.30982831
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.30109574
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28005625
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28005625
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.27773200
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27005139
58	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25939330
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25575717
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24166475
61	TCF4_23295773_ChIP-Seq_U87_Human	1.23830646
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.23479758
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.22604565
64	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.22235453
65	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.21942472
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.20308523
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.20258461
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.19324654
69	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18154078
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17995964
71	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.17554604
72	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15432551
73	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14439248
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12964621
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12611903
76	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12266995
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10902637
78	AR_21572438_ChIP-Seq_LNCaP_Human	1.08979835
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.08828159
80	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08734010
81	SOX2_19829295_ChIP-Seq_ESCs_Human	1.08466837
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.08466837
83	TCF4_22108803_ChIP-Seq_LS180_Human	1.08327006
84	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.07136635
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07003041
86	JUN_21703547_ChIP-Seq_K562_Human	1.05448925
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.04706430
88	IRF1_19129219_ChIP-ChIP_H3396_Human	1.04335049
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03450094
90	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.03306219
91	DROSHA_22980978_ChIP-Seq_HELA_Human	1.03148441
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.02198810
93	HTT_18923047_ChIP-ChIP_STHdh_Human	1.01878014
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01470197
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.01240337
96	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00946459
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.00668410
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97161494
99	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.94595486
100	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.94421777

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.75117435
2	MP0004859_abnormal_synaptic_plasticity	3.04502709
3	MP0004270_analgesia	2.68588872
4	MP0009046_muscle_twitch	2.68439527
5	MP0009745_abnormal_behavioral_response	2.58389568
6	MP0001984_abnormal_olfaction	2.53483695
7	MP0005423_abnormal_somatic_nervous	2.50824640
8	MP0003635_abnormal_synaptic_transmissio	2.44743591
9	MP0001968_abnormal_touch/_nociception	2.44736824
10	MP0002272_abnormal_nervous_system	2.38212738
11	MP0002064_seizures	2.33913392
12	MP0002102_abnormal_ear_morphology	2.30290409
13	MP0002735_abnormal_chemical_nociception	2.30201378
14	MP0001529_abnormal_vocalization	2.27154593
15	MP0001486_abnormal_startle_reflex	2.25577737
16	MP0002822_catalepsy	2.23596699
17	MP0002638_abnormal_pupillary_reflex	2.19673033
18	MP0002063_abnormal_learning/memory/cond	2.18319477
19	MP0002572_abnormal_emotion/affect_behav	2.14024905
20	MP0002736_abnormal_nociception_after	2.13491730
21	MP0003787_abnormal_imprinting	2.11153241
22	MP0006276_abnormal_autonomic_nervous	2.04770613
23	MP0002734_abnormal_mechanical_nocicepti	2.03158795
24	MP0001970_abnormal_pain_threshold	1.85602280
25	MP0005551_abnormal_eye_electrophysiolog	1.84833083
26	MP0000778_abnormal_nervous_system	1.84160192
27	MP0004142_abnormal_muscle_tone	1.80816815
28	MP0002653_abnormal_ependyma_morphology	1.74402696
29	MP0001501_abnormal_sleep_pattern	1.73009620
30	MP0000569_abnormal_digit_pigmentation	1.72695050
31	MP0005645_abnormal_hypothalamus_physiol	1.70291953
32	MP0002733_abnormal_thermal_nociception	1.70182325
33	MP0002909_abnormal_adrenal_gland	1.70112908
34	MP0002557_abnormal_social/conspecific_i	1.69389362
35	MP0001905_abnormal_dopamine_level	1.69296581
36	MP0004885_abnormal_endolymph	1.67452422
37	MP0003136_yellow_coat_color	1.65674634
38	MP0002067_abnormal_sensory_capabilities	1.63411044
39	MP0003011_delayed_dark_adaptation	1.62087702
40	MP0005253_abnormal_eye_physiology	1.60280577
41	MP0004133_heterotaxia	1.55753208
42	MP0005386_behavior/neurological_phenoty	1.52582898
43	MP0004924_abnormal_behavior	1.52582898
44	MP0010386_abnormal_urinary_bladder	1.52442279
45	MP0003122_maternal_imprinting	1.50774290
46	MP0008877_abnormal_DNA_methylation	1.48789956
47	MP0006072_abnormal_retinal_apoptosis	1.41295398
48	MP0004742_abnormal_vestibular_system	1.40368534
49	MP0001188_hyperpigmentation	1.40215368
50	MP0001986_abnormal_taste_sensitivity	1.37394651
51	MP0005646_abnormal_pituitary_gland	1.35856725
52	MP0004043_abnormal_pH_regulation	1.34921754
53	MP0002837_dystrophic_cardiac_calcinosis	1.30979049
54	MP0003195_calcinosis	1.27243764
55	MP0004811_abnormal_neuron_physiology	1.26090412
56	MP0002882_abnormal_neuron_morphology	1.25238700
57	MP0000955_abnormal_spinal_cord	1.25011990
58	MP0001502_abnormal_circadian_rhythm	1.24175788
59	MP0002184_abnormal_innervation	1.18342792
60	MP0005394_taste/olfaction_phenotype	1.17714090
61	MP0005499_abnormal_olfactory_system	1.17714090
62	MP0000631_abnormal_neuroendocrine_gland	1.13467938
63	MP0005167_abnormal_blood-brain_barrier	1.12817127
64	MP0003633_abnormal_nervous_system	1.12758985
65	MP0005084_abnormal_gallbladder_morpholo	1.10167531
66	MP0003121_genomic_imprinting	1.09363765
67	MP0008789_abnormal_olfactory_epithelium	1.08449069
68	MP0002229_neurodegeneration	1.07995129
69	MP0005187_abnormal_penis_morphology	1.07900646
70	MP0001485_abnormal_pinna_reflex	1.07575684
71	MP0001440_abnormal_grooming_behavior	1.05633119
72	MP0008875_abnormal_xenobiotic_pharmacok	1.04776372
73	MP0002066_abnormal_motor_capabilities/c	1.04069532
74	MP0008569_lethality_at_weaning	1.03579710
75	MP0000026_abnormal_inner_ear	1.02211310
76	MP0008872_abnormal_physiological_respon	1.02013848
77	MP0002876_abnormal_thyroid_physiology	1.01804657
78	MP0002752_abnormal_somatic_nervous	0.98768449
79	MP0004147_increased_porphyrin_level	0.97962909
80	MP0002928_abnormal_bile_duct	0.96440618
81	MP0002751_abnormal_autonomic_nervous	0.94107036
82	MP0001963_abnormal_hearing_physiology	0.93944353
83	MP0003631_nervous_system_phenotype	0.89599298
84	MP0002090_abnormal_vision	0.89549718
85	MP0008995_early_reproductive_senescence	0.86794176
86	MP0004215_abnormal_myocardial_fiber	0.86129661
87	MP0002069_abnormal_eating/drinking_beha	0.85983086
88	MP0003137_abnormal_impulse_conducting	0.85937040
89	MP0002152_abnormal_brain_morphology	0.83487215
90	MP0005195_abnormal_posterior_eye	0.82202248
91	MP0003879_abnormal_hair_cell	0.81885235
92	MP0000647_abnormal_sebaceous_gland	0.78180944
93	MP0002277_abnormal_respiratory_mucosa	0.75787748
94	MP0005535_abnormal_body_temperature	0.73610318
95	MP0005248_abnormal_Harderian_gland	0.73563632
96	MP0000427_abnormal_hair_cycle	0.71511789
97	MP0004085_abnormal_heartbeat	0.70430488
98	MP0005171_absent_coat_pigmentation	0.68286784
99	MP0002234_abnormal_pharynx_morphology	0.67022232
100	MP0003632_abnormal_nervous_system	0.65409771

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Polyphagia (HP:0002591)	3.65694000
2	Medial flaring of the eyebrow (HP:0010747)	3.62679252
3	Focal motor seizures (HP:0011153)	3.62293061
4	Gait imbalance (HP:0002141)	3.58029615
5	Pancreatic cysts (HP:0001737)	3.47018900
6	True hermaphroditism (HP:0010459)	3.41268635
7	Pancreatic fibrosis (HP:0100732)	3.34088936
8	Febrile seizures (HP:0002373)	3.32714393
9	Congenital primary aphakia (HP:0007707)	3.27291019
10	Hyperventilation (HP:0002883)	3.14427950
11	Abnormality of midbrain morphology (HP:0002418)	3.14369698
12	Molar tooth sign on MRI (HP:0002419)	3.14369698
13	Progressive cerebellar ataxia (HP:0002073)	3.12483819
14	Limb dystonia (HP:0002451)	3.11655750
15	Nephrogenic diabetes insipidus (HP:0009806)	3.06023235
16	Hemiparesis (HP:0001269)	2.94394436
17	Focal seizures (HP:0007359)	2.93850389
18	Myokymia (HP:0002411)	2.90537740
19	Epileptic encephalopathy (HP:0200134)	2.86865754
20	Nephronophthisis (HP:0000090)	2.85530894
21	Atonic seizures (HP:0010819)	2.85185018
22	Absent speech (HP:0001344)	2.72567221
23	Genital tract atresia (HP:0001827)	2.64104102
24	Drooling (HP:0002307)	2.61480038
25	Broad-based gait (HP:0002136)	2.60274772
26	Renal cortical cysts (HP:0000803)	2.60179616
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.58222036
28	Abnormal respiratory epithelium morphology (HP:0012253)	2.58222036
29	Abnormal eating behavior (HP:0100738)	2.56487404
30	Acute necrotizing encephalopathy (HP:0006965)	2.54255955
31	Vaginal atresia (HP:0000148)	2.51587368
32	Agitation (HP:0000713)	2.51018386
33	Lissencephaly (HP:0001339)	2.48766397
34	Dialeptic seizures (HP:0011146)	2.47125422
35	Progressive macrocephaly (HP:0004481)	2.46674230
36	Abnormal ciliary motility (HP:0012262)	2.45874591
37	Inability to walk (HP:0002540)	2.45765398
38	Epileptiform EEG discharges (HP:0011182)	2.42160108
39	Hypsarrhythmia (HP:0002521)	2.40197626
40	Excessive salivation (HP:0003781)	2.39959045
41	Abnormality of the renal cortex (HP:0011035)	2.39645970
42	EEG with generalized epileptiform discharges (HP:0011198)	2.39638972
43	Abnormality of the renal medulla (HP:0100957)	2.37586570
44	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.37198874
45	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.37198874
46	Type II lissencephaly (HP:0007260)	2.35356076
47	Mitochondrial inheritance (HP:0001427)	2.33732267
48	Specific learning disability (HP:0001328)	2.33676589
49	Absent/shortened dynein arms (HP:0200106)	2.33654174
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.33654174
51	Chronic hepatic failure (HP:0100626)	2.30778574
52	Split foot (HP:0001839)	2.27379613
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.25674941
54	Congenital stationary night blindness (HP:0007642)	2.25635802
55	Abnormal mitochondria in muscle tissue (HP:0008316)	2.25587084
56	Pachygyria (HP:0001302)	2.24764811
57	Generalized tonic-clonic seizures (HP:0002069)	2.21763503
58	Retinal dysplasia (HP:0007973)	2.17615865
59	3-Methylglutaconic aciduria (HP:0003535)	2.16516179
60	Progressive inability to walk (HP:0002505)	2.15980624
61	Absence seizures (HP:0002121)	2.13192540
62	Action tremor (HP:0002345)	2.13025426
63	Gaze-evoked nystagmus (HP:0000640)	2.10213550
64	Ankle clonus (HP:0011448)	2.09594288
65	Poor coordination (HP:0002370)	2.07779904
66	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07437380
67	Abolished electroretinogram (ERG) (HP:0000550)	2.07043599
68	Abnormality of the corticospinal tract (HP:0002492)	2.06830706
69	Genetic anticipation (HP:0003743)	2.06732788
70	Spastic tetraplegia (HP:0002510)	2.06021242
71	Cystic liver disease (HP:0006706)	2.05326464
72	Mutism (HP:0002300)	2.04912908
73	Increased CSF lactate (HP:0002490)	2.04781094
74	Failure to thrive in infancy (HP:0001531)	2.02774635
75	Acute encephalopathy (HP:0006846)	2.01597111
76	Poor suck (HP:0002033)	2.00860773
77	Decreased central vision (HP:0007663)	1.99669191
78	Hypothermia (HP:0002045)	1.99036660
79	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.99034299
80	Abnormality of alanine metabolism (HP:0010916)	1.99034299
81	Hyperalaninemia (HP:0003348)	1.99034299
82	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.98807774
83	Amyotrophic lateral sclerosis (HP:0007354)	1.98515118
84	Postaxial hand polydactyly (HP:0001162)	1.96071484
85	Polydipsia (HP:0001959)	1.95251404
86	Abnormal drinking behavior (HP:0030082)	1.95251404
87	Spastic gait (HP:0002064)	1.95075371
88	Methylmalonic acidemia (HP:0002912)	1.94668908
89	Short tibia (HP:0005736)	1.93500063
90	Attenuation of retinal blood vessels (HP:0007843)	1.91195743
91	Large for gestational age (HP:0001520)	1.88847238
92	Occipital encephalocele (HP:0002085)	1.88493089
93	Optic disc pallor (HP:0000543)	1.87528454
94	Increased hepatocellular lipid droplets (HP:0006565)	1.84626067
95	Rhinitis (HP:0012384)	1.83644368
96	Bile duct proliferation (HP:0001408)	1.82706210
97	Abnormal biliary tract physiology (HP:0012439)	1.82706210
98	Lipid accumulation in hepatocytes (HP:0006561)	1.82309418
99	Thyroid-stimulating hormone excess (HP:0002925)	1.81728493
100	Urinary urgency (HP:0000012)	1.81228117

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.68939254
2	MAP3K4	3.45847318
3	CASK	3.23874311
4	MAP4K2	3.10372197
5	MAP2K7	2.92325296
6	FRK	2.81063934
7	WNK3	2.65748260
8	MAPK13	2.47485598
9	BCR	2.46197951
10	PINK1	2.37086595
11	ADRBK2	2.26847638
12	EPHA3	2.05549392
13	TRIM28	2.02678970
14	NTRK2	1.87716049
15	ERBB3	1.87597848
16	NTRK3	1.85528060
17	DAPK2	1.82764571
18	BMPR1B	1.74828381
19	EPHA4	1.72250858
20	CSNK1G2	1.62394601
21	PAK3	1.60963755
22	DYRK2	1.60642214
23	CSNK1G3	1.40045308
24	MAP2K4	1.38754776
25	CAMKK2	1.38637079
26	UHMK1	1.36279349
27	GRK1	1.32422938
28	PLK2	1.31704062
29	PRKCG	1.28011959
30	CSNK1A1L	1.26915691
31	MAPK15	1.25089022
32	DYRK3	1.17403103
33	INSRR	1.15075605
34	PAK6	1.14517001
35	CSNK1G1	1.13789594
36	PRKCE	1.12515989
37	BCKDK	1.12085402
38	MINK1	1.09338040
39	SIK2	0.99777383
40	CAMK2A	0.96121313
41	WNK4	0.91058620
42	PKN1	0.88423686
43	DYRK1B	0.87021292
44	CDK5	0.86529799
45	LIMK1	0.86394297
46	TNIK	0.84827562
47	SGK494	0.84521580
48	SGK223	0.84521580
49	PHKG1	0.84158001
50	PHKG2	0.84158001
51	TAOK3	0.83549048
52	OXSR1	0.79586029
53	CAMK2B	0.79098371
54	DYRK1A	0.78903705
55	CDK19	0.74742118
56	ACVR1B	0.69510589
57	SGK2	0.67211553
58	ADRBK1	0.64777784
59	MAP3K12	0.63423467
60	ZAK	0.63095680
61	GRK5	0.59226540
62	MAPKAPK5	0.58293346
63	PRKACA	0.57995102
64	CAMKK1	0.56648739
65	TLK1	0.56249218
66	MST4	0.55142084
67	STK38L	0.55120595
68	MUSK	0.54662969
69	PRKCZ	0.54553668
70	FER	0.54306469
71	AKT3	0.51701584
72	CAMK2D	0.51385304
73	CCNB1	0.50699542
74	STK39	0.50481270
75	MAP3K5	0.50380358
76	CAMK2G	0.49978308
77	TESK1	0.48555790
78	CAMK4	0.48516583
79	RPS6KA4	0.48507829
80	CDK14	0.48405213
81	EPHB2	0.46709449
82	FGFR2	0.46096127
83	PRKG1	0.45913691
84	PNCK	0.45745049
85	KSR1	0.43296727
86	CAMK1	0.39573177
87	CSNK1A1	0.39319338
88	GRK7	0.39271953
89	SIK3	0.37723196
90	PRKACB	0.37573727
91	CSNK1D	0.37376548
92	TNK2	0.37255899
93	RPS6KA5	0.36134331
94	TXK	0.36106181
95	PRKCA	0.35754859
96	CDK18	0.35403187
97	NUAK1	0.34605804
98	PRKACG	0.32633072
99	MAP3K6	0.31920108
100	STK11	0.31852104

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.88715143
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.93467841
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.84325202
4	GABAergic synapse_Homo sapiens_hsa04727	2.71009954
5	Collecting duct acid secretion_Homo sapiens_hsa04966	2.55617165
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.44153516
7	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.40358818
8	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.38848785
9	Morphine addiction_Homo sapiens_hsa05032	2.35730968
10	Protein export_Homo sapiens_hsa03060	2.31937936
11	Phototransduction_Homo sapiens_hsa04744	2.20626023
12	Parkinsons disease_Homo sapiens_hsa05012	2.15407681
13	Butanoate metabolism_Homo sapiens_hsa00650	2.11935163
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.02446838
15	Glutamatergic synapse_Homo sapiens_hsa04724	2.01308897
16	Circadian entrainment_Homo sapiens_hsa04713	1.99915155
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.98348199
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.74877556
19	Dopaminergic synapse_Homo sapiens_hsa04728	1.73330885
20	Taste transduction_Homo sapiens_hsa04742	1.72446076
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.68037056
22	Cocaine addiction_Homo sapiens_hsa05030	1.59701344
23	Regulation of autophagy_Homo sapiens_hsa04140	1.52624697
24	Alzheimers disease_Homo sapiens_hsa05010	1.51533742
25	Amphetamine addiction_Homo sapiens_hsa05031	1.49822344
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.49085394
27	Serotonergic synapse_Homo sapiens_hsa04726	1.43483020
28	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.42359637
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.40448849
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.37554744
31	Insulin secretion_Homo sapiens_hsa04911	1.35730994
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34433158
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33622175
34	Huntingtons disease_Homo sapiens_hsa05016	1.29152920
35	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.25750208
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24430104
37	Peroxisome_Homo sapiens_hsa04146	1.21195987
38	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.20675217
39	Circadian rhythm_Homo sapiens_hsa04710	1.13428841
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.08699345
41	Ether lipid metabolism_Homo sapiens_hsa00565	1.08020898
42	Olfactory transduction_Homo sapiens_hsa04740	1.04769674
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.04208700
44	Steroid biosynthesis_Homo sapiens_hsa00100	1.04207086
45	Long-term depression_Homo sapiens_hsa04730	1.02409462
46	beta-Alanine metabolism_Homo sapiens_hsa00410	1.01895712
47	Cholinergic synapse_Homo sapiens_hsa04725	1.01356520
48	Propanoate metabolism_Homo sapiens_hsa00640	0.97630062
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95603349
50	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.90186145
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.86174859
52	Caffeine metabolism_Homo sapiens_hsa00232	0.83484979
53	Vibrio cholerae infection_Homo sapiens_hsa05110	0.83315239
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.82436249
55	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.82269311
56	Renin secretion_Homo sapiens_hsa04924	0.80396040
57	Salivary secretion_Homo sapiens_hsa04970	0.80293202
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72715018
59	Fatty acid elongation_Homo sapiens_hsa00062	0.72056001
60	Gastric acid secretion_Homo sapiens_hsa04971	0.69386176
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68730212
62	Axon guidance_Homo sapiens_hsa04360	0.68273774
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.66467906
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.65729868
65	cAMP signaling pathway_Homo sapiens_hsa04024	0.64629794
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63055165
67	ABC transporters_Homo sapiens_hsa02010	0.62770752
68	Basal transcription factors_Homo sapiens_hsa03022	0.59520494
69	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.59455467
70	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.58159956
71	Rheumatoid arthritis_Homo sapiens_hsa05323	0.55998458
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54253015
73	Histidine metabolism_Homo sapiens_hsa00340	0.53624827
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.51829173
75	Retinol metabolism_Homo sapiens_hsa00830	0.50462788
76	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49903877
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.46969541
78	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45568648
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43787265
80	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.43648038
81	Phagosome_Homo sapiens_hsa04145	0.43000895
82	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.41932250
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41537456
84	Metabolic pathways_Homo sapiens_hsa01100	0.40290059
85	Folate biosynthesis_Homo sapiens_hsa00790	0.39376480
86	Sulfur metabolism_Homo sapiens_hsa00920	0.38316827
87	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37835153
88	Type II diabetes mellitus_Homo sapiens_hsa04930	0.37663663
89	Alcoholism_Homo sapiens_hsa05034	0.37032636
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36214394
91	Gap junction_Homo sapiens_hsa04540	0.33315786
92	Ras signaling pathway_Homo sapiens_hsa04014	0.32354040
93	Long-term potentiation_Homo sapiens_hsa04720	0.30221432
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.28639397
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28500143
96	Mineral absorption_Homo sapiens_hsa04978	0.27477311
97	RNA polymerase_Homo sapiens_hsa03020	0.27384238
98	Pancreatic secretion_Homo sapiens_hsa04972	0.26535298
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25765190
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.22147584

C18ORF32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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