C18ORF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a colon cancer associated protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.91628357
2negative regulation of cell killing (GO:0031342)4.85039748
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.85039748
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.58132133
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16916135
6neutrophil activation involved in immune response (GO:0002283)4.16773361
7antigen processing and presentation of endogenous antigen (GO:0019883)4.12338409
8positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.07360058
9immunoglobulin mediated immune response (GO:0016064)4.05905686
10NIK/NF-kappaB signaling (GO:0038061)3.97003814
11positive regulation by symbiont of host defense response (GO:0052509)3.92954270
12modulation by symbiont of host defense response (GO:0052031)3.92954270
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.92954270
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.92954270
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.92954270
16modulation by symbiont of host immune response (GO:0052553)3.92954270
17regulation of B cell receptor signaling pathway (GO:0050855)3.90697934
18positive regulation of humoral immune response (GO:0002922)3.76628848
19response to peptidoglycan (GO:0032494)3.64876324
20macrophage activation involved in immune response (GO:0002281)3.61877208
21negative regulation of interleukin-12 production (GO:0032695)3.57316288
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52818782
23positive regulation of isotype switching (GO:0045830)3.46708704
24regulation of gamma-delta T cell activation (GO:0046643)3.42437211
25detection of other organism (GO:0098543)3.36849272
26type I interferon signaling pathway (GO:0060337)3.31420018
27cellular response to type I interferon (GO:0071357)3.31420018
28positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.30396534
29detection of bacterium (GO:0016045)3.29025274
30response to type I interferon (GO:0034340)3.25737180
31B cell mediated immunity (GO:0019724)3.25702873
32regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24754655
33B cell receptor signaling pathway (GO:0050853)3.15804540
34regulation of interferon-beta biosynthetic process (GO:0045357)3.11007889
35neutrophil activation (GO:0042119)3.10030756
36granulocyte activation (GO:0036230)3.08574548
37interferon-gamma-mediated signaling pathway (GO:0060333)3.07227195
38myeloid cell activation involved in immune response (GO:0002275)3.03513227
39regulation of gamma-delta T cell differentiation (GO:0045586)3.03371559
40regulation of alpha-beta T cell proliferation (GO:0046640)3.01692238
41T cell migration (GO:0072678)3.00760983
42negative regulation of T cell mediated immunity (GO:0002710)2.98623712
43positive regulation of B cell mediated immunity (GO:0002714)2.97627365
44positive regulation of immunoglobulin mediated immune response (GO:0002891)2.97627365
45positive regulation of DNA recombination (GO:0045911)2.96106160
46piRNA metabolic process (GO:0034587)2.93961559
47negative thymic T cell selection (GO:0045060)2.93148770
48defense response to protozoan (GO:0042832)2.92536146
49lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91354318
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91216253
51regulation of mast cell degranulation (GO:0043304)2.91051931
52leukocyte aggregation (GO:0070486)2.88743158
53T-helper 1 type immune response (GO:0042088)2.88233729
54negative regulation of lymphocyte mediated immunity (GO:0002707)2.88207193
55cellular extravasation (GO:0045123)2.87611789
56positive regulation of mast cell activation (GO:0033005)2.84557163
57response to protozoan (GO:0001562)2.83000391
58regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.81713902
59negative T cell selection (GO:0043383)2.79373053
60response to muramyl dipeptide (GO:0032495)2.78407617
61positive regulation of B cell differentiation (GO:0045579)2.78347608
62regulation of natural killer cell mediated immunity (GO:0002715)2.74358911
63regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.74358911
64detection of external biotic stimulus (GO:0098581)2.74270491
65negative regulation of innate immune response (GO:0045824)2.73742123
66response to interleukin-15 (GO:0070672)2.73549226
67cellular response to interleukin-15 (GO:0071350)2.72598984
68microglial cell activation (GO:0001774)2.71720478
69regulation of B cell differentiation (GO:0045577)2.71569871
70regulation of T cell tolerance induction (GO:0002664)2.71267441
71leukocyte degranulation (GO:0043299)2.69168103
72regulation of mast cell activation involved in immune response (GO:0033006)2.69128700
73antigen processing and presentation via MHC class Ib (GO:0002475)2.68906027
74positive regulation of interferon-beta production (GO:0032728)2.68357089
75regulation of interferon-alpha production (GO:0032647)2.67153248
76tolerance induction (GO:0002507)2.66154538
77positive regulation of type 2 immune response (GO:0002830)2.65955976
78regulation of T cell mediated cytotoxicity (GO:0001914)2.65946267
79positive regulation of interferon-alpha production (GO:0032727)2.65526793
80response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62593818
81response to host immune response (GO:0052572)2.62593818
82respiratory burst (GO:0045730)2.61399460
83regulation of T-helper 1 cell differentiation (GO:0045625)2.60903001
84regulation of isotype switching (GO:0045191)2.59212335
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.56443259
86positive regulation of interleukin-17 production (GO:0032740)2.55144441
87positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54884017
88interferon-gamma production (GO:0032609)2.54871930
89macrophage activation (GO:0042116)2.54732454
90regulation of mast cell activation (GO:0033003)2.53500505
91myeloid dendritic cell differentiation (GO:0043011)2.53040646
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.52666289
93positive regulation of antigen processing and presentation (GO:0002579)2.52661209
94regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.52586772
95negative regulation of leukocyte mediated immunity (GO:0002704)2.52196779
96positive thymic T cell selection (GO:0045059)2.52019239
97positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.51571932
98detection of molecule of bacterial origin (GO:0032490)2.50123770
99negative regulation of glycoprotein biosynthetic process (GO:0010561)2.49598569
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.48680749

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.75794506
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.30556877
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.19940935
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.97541921
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.72897871
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.62323806
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.19876373
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.14928687
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03092984
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85245559
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.81534662
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.76998444
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75646868
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73176378
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.70440754
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56331881
17MYB_26560356_Chip-Seq_TH2_Human2.47456162
18SPI1_23547873_ChIP-Seq_NB4_Human2.46464657
19* RUNX_20019798_ChIP-Seq_JUKART_Human2.45329113
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26076651
21SCL_19346495_ChIP-Seq_HPC-7_Human2.25399674
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.16059494
23MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08593483
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.05968198
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04685715
26MAF_26560356_Chip-Seq_TH1_Human2.03531973
27VDR_24763502_ChIP-Seq_THP-1_Human2.02956139
28MYB_26560356_Chip-Seq_TH1_Human2.02951266
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98519389
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.97451585
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96664636
32VDR_21846776_ChIP-Seq_THP-1_Human1.96066682
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.93107135
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89566038
35UTX_26944678_Chip-Seq_JUKART_Human1.88468392
36SPI1_23127762_ChIP-Seq_K562_Human1.88013804
37MYC_22102868_ChIP-Seq_BL_Human1.87512969
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.79953451
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.75715715
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.75464253
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.69041989
42GATA3_27048872_Chip-Seq_THYMUS_Human1.65083632
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64820567
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64697741
45TFEB_21752829_ChIP-Seq_HELA_Human1.58316144
46EZH2_22144423_ChIP-Seq_EOC_Human1.55599615
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54260598
48GATA1_22025678_ChIP-Seq_K562_Human1.50911785
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49507688
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48879750
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.48272434
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47440690
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.47300239
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41658747
55MAF_26560356_Chip-Seq_TH2_Human1.41474935
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41391636
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40967611
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34626627
59GATA3_26560356_Chip-Seq_TH2_Human1.33658169
60TCF7_22412390_ChIP-Seq_EML_Mouse1.33470747
61TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33047206
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27594027
63PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26235457
64GATA1_19941826_ChIP-Seq_K562_Human1.21873471
65PU_27001747_Chip-Seq_BMDM_Mouse1.19634863
66VDR_24787735_ChIP-Seq_THP-1_Human1.16728171
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15803879
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14455551
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13307902
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12000448
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11033089
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10645786
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09810905
74NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08169885
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08041545
76BCL6_27268052_Chip-Seq_Bcells_Human1.07329203
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06497576
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05719278
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04424496
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04105226
81CIITA_25753668_ChIP-Seq_RAJI_Human1.04003273
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03035869
83* VDR_23849224_ChIP-Seq_CD4+_Human1.01560383
84NCOR1_26117541_ChIP-Seq_K562_Human0.98303906
85GATA2_19941826_ChIP-Seq_K562_Human0.97250190
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96654384
87KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95907410
88ELF1_20517297_ChIP-Seq_JURKAT_Human0.94927396
89KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94643873
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94432994
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94130272
92CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93565993
93GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91111384
94BCOR_27268052_Chip-Seq_Bcells_Human0.89048489
95SMRT_27268052_Chip-Seq_Bcells_Human0.88320509
96* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88074685
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87952323
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87732634
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85644006
100KDM2B_26808549_Chip-Seq_DND41_Human0.84269128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.34686689
2MP0003303_peritoneal_inflammation3.33250338
3MP0003436_decreased_susceptibility_to3.31536972
4MP0006082_CNS_inflammation3.11081901
5MP0005671_abnormal_response_to2.99725915
6MP0003724_increased_susceptibility_to2.90990785
7MP0000685_abnormal_immune_system2.79170767
8MP0005000_abnormal_immune_tolerance2.77991737
9MP0009785_altered_susceptibility_to2.77260554
10MP0005387_immune_system_phenotype2.74010689
11MP0001790_abnormal_immune_system2.74010689
12MP0001800_abnormal_humoral_immune2.69331966
13MP0009840_abnormal_foam_cell2.55785814
14MP0002723_abnormal_immune_serum2.44928505
15MP0003763_abnormal_thymus_physiology2.44923651
16MP0005451_abnormal_body_composition2.44505144
17MP0002419_abnormal_innate_immunity2.40908920
18MP0005464_abnormal_platelet_physiology2.39084045
19MP0002452_abnormal_antigen_presenting2.36028037
20MP0005025_abnormal_response_to2.35625270
21MP0002148_abnormal_hypersensitivity_rea2.30446887
22MP0002420_abnormal_adaptive_immunity2.25505487
23MP0001819_abnormal_immune_cell2.21889616
24MP0003300_gastrointestinal_ulcer2.21393483
25MP0009333_abnormal_splenocyte_physiolog2.11384566
26MP0002138_abnormal_hepatobiliary_system2.00730002
27MP0002398_abnormal_bone_marrow1.99321248
28MP0003656_abnormal_erythrocyte_physiolo1.97723399
29MP0002405_respiratory_system_inflammati1.96571738
30MP0008260_abnormal_autophagy1.95436638
31MP0010155_abnormal_intestine_physiology1.87574445
32MP0000716_abnormal_immune_system1.82840822
33MP0005310_abnormal_salivary_gland1.82834676
34MP0002139_abnormal_hepatobiliary_system1.78744544
35MP0003183_abnormal_peptide_metabolism1.75108363
36MP0001845_abnormal_inflammatory_respons1.70445412
37MP0004947_skin_inflammation1.68797552
38MP0000689_abnormal_spleen_morphology1.64569726
39MP0003191_abnormal_cellular_cholesterol1.62455139
40MP0000465_gastrointestinal_hemorrhage1.62241123
41MP0002722_abnormal_immune_system1.57455182
42MP0005058_abnormal_lysosome_morphology1.56168168
43MP0009764_decreased_sensitivity_to1.51001727
44MP0002429_abnormal_blood_cell1.49698475
45MP0002132_abnormal_respiratory_system1.48097959
46MP0005397_hematopoietic_system_phenotyp1.46884887
47MP0001545_abnormal_hematopoietic_system1.46884887
48MP0000015_abnormal_ear_pigmentation1.43739028
49MP0008469_abnormal_protein_level1.42379620
50MP0003172_abnormal_lysosome_physiology1.40493141
51MP0001873_stomach_inflammation1.38619508
52MP0009278_abnormal_bone_marrow1.37486584
53MP0000703_abnormal_thymus_morphology1.36001477
54MP0003718_maternal_effect1.33967734
55MP0001533_abnormal_skeleton_physiology1.28798505
56MP0003866_abnormal_defecation1.24025420
57MP0008004_abnormal_stomach_pH1.08532251
58MP0000858_altered_metastatic_potential1.06890062
59MP0004510_myositis1.01706543
60MP0002998_abnormal_bone_remodeling1.01650231
61MP0000343_altered_response_to1.01124072
62MP0004808_abnormal_hematopoietic_stem1.00265198
63MP0000604_amyloidosis0.94511130
64MP0009763_increased_sensitivity_to0.94013861
65MP0001851_eye_inflammation0.93204630
66MP0000490_abnormal_crypts_of0.92681259
67MP0005166_decreased_susceptibility_to0.90406070
68MP0001853_heart_inflammation0.90293141
69MP0009765_abnormal_xenobiotic_induced0.89444065
70MP0003828_pulmonary_edema0.86214393
71MP0003690_abnormal_glial_cell0.81448544
72MP0003221_abnormal_cardiomyocyte_apopto0.79220471
73MP0002332_abnormal_exercise_endurance0.78921709
74MP0005360_urolithiasis0.76948392
75MP0005075_abnormal_melanosome_morpholog0.74779108
76MP0002166_altered_tumor_susceptibility0.73984223
77MP0000609_abnormal_liver_physiology0.73635132
78MP0001663_abnormal_digestive_system0.73038793
79MP0008874_decreased_physiological_sensi0.72711770
80MP0003075_altered_response_to0.70284563
81MP0003252_abnormal_bile_duct0.68441778
82MP0002396_abnormal_hematopoietic_system0.67986629
83MP0002019_abnormal_tumor_incidence0.67962899
84MP0005410_abnormal_fertilization0.67381372
85MP0003448_altered_tumor_morphology0.66782455
86MP0004381_abnormal_hair_follicle0.66530272
87MP0005319_abnormal_enzyme/_coenzyme0.65318277
88MP0003879_abnormal_hair_cell0.64946229
89MP0003806_abnormal_nucleotide_metabolis0.63953039
90MP0008877_abnormal_DNA_methylation0.61592809
91MP0003950_abnormal_plasma_membrane0.60767535
92MP0003329_amyloid_beta_deposits0.60236464
93MP0002006_tumorigenesis0.58473113
94MP0005164_abnormal_response_to0.57550706
95MP0005085_abnormal_gallbladder_physiolo0.57181561
96MP0008961_abnormal_basal_metabolism0.55791234
97MP0005395_other_phenotype0.54652655
98MP0002163_abnormal_gland_morphology0.54366020
99MP0002277_abnormal_respiratory_mucosa0.53626481
100MP0003795_abnormal_bone_structure0.52925302

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.85439799
2Stomatitis (HP:0010280)4.28557247
3Eczematoid dermatitis (HP:0000976)4.07476027
4Recurrent bacterial skin infections (HP:0005406)4.05411518
5Recurrent abscess formation (HP:0002722)3.93219062
6Increased IgM level (HP:0003496)3.91741376
7Myositis (HP:0100614)3.80971900
8Recurrent fungal infections (HP:0002841)3.77001402
9Recurrent cutaneous fungal infections (HP:0011370)3.74686867
10Chronic mucocutaneous candidiasis (HP:0002728)3.74686867
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.72223735
12Retrobulbar optic neuritis (HP:0100654)3.71950451
13Optic neuritis (HP:0100653)3.71950451
14Orchitis (HP:0100796)3.63606563
15Loss of speech (HP:0002371)3.63218122
16Abnormality of T cell number (HP:0011839)3.52557337
17T lymphocytopenia (HP:0005403)3.51149315
18Vasculitis (HP:0002633)3.39267977
19Recurrent skin infections (HP:0001581)3.21701075
20Recurrent viral infections (HP:0004429)3.20165622
21Meningitis (HP:0001287)3.17724407
22Elevated erythrocyte sedimentation rate (HP:0003565)3.14355377
23Mediastinal lymphadenopathy (HP:0100721)3.12985731
24Encephalitis (HP:0002383)3.12221905
25Autoimmune thrombocytopenia (HP:0001973)3.08667699
26Agammaglobulinemia (HP:0004432)3.07333645
27Abnormality of T cells (HP:0002843)2.95831917
28Autoimmune hemolytic anemia (HP:0001890)2.91789531
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.88006640
30Prolonged bleeding time (HP:0003010)2.87719866
31Obstructive lung disease (HP:0006536)2.83247375
32Chronic obstructive pulmonary disease (HP:0006510)2.83247375
33Gastrointestinal stroma tumor (HP:0100723)2.78521334
34Gastrointestinal infarctions (HP:0005244)2.77478441
35Recurrent gram-negative bacterial infections (HP:0005420)2.74511684
36Petechiae (HP:0000967)2.72096589
37Gingival bleeding (HP:0000225)2.70816669
38Keratoconjunctivitis (HP:0001096)2.68756920
39Abnormality of liposaccharide metabolism (HP:0010968)2.66293749
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.66293749
41Abnormality of glycolipid metabolism (HP:0010969)2.66293749
42Urticaria (HP:0001025)2.65433581
43Pulmonary infiltrates (HP:0002113)2.61241603
44Chronic diarrhea (HP:0002028)2.59506910
45Lymphopenia (HP:0001888)2.58579054
46Leukocytosis (HP:0001974)2.58103080
47Epistaxis (HP:0000421)2.56286570
48Abnormality of T cell physiology (HP:0011840)2.55427710
49Panhypogammaglobulinemia (HP:0003139)2.55233511
50Pustule (HP:0200039)2.53424098
51Granulocytopenia (HP:0001913)2.52922632
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.50300014
53Inflammation of the large intestine (HP:0002037)2.49559298
54Keratoconjunctivitis sicca (HP:0001097)2.47093244
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43250166
56Hypergammaglobulinemia (HP:0010702)2.38656647
57Gastrointestinal inflammation (HP:0004386)2.37692949
58Purpura (HP:0000979)2.37607081
59Abnormality of B cell number (HP:0010975)2.35110724
60Increased IgE level (HP:0003212)2.32890382
61Osteomyelitis (HP:0002754)2.32761806
62Acute hepatic failure (HP:0006554)2.31713309
63Eosinophilia (HP:0001880)2.29345172
64Generalized aminoaciduria (HP:0002909)2.28761679
65Spontaneous hematomas (HP:0007420)2.26774678
66Vacuolated lymphocytes (HP:0001922)2.23612514
67Fatigue (HP:0012378)2.23507274
68Progressive neurologic deterioration (HP:0002344)2.23005749
69Male infertility (HP:0003251)2.22183394
70Cellulitis (HP:0100658)2.21983403
71Anorexia (HP:0002039)2.21009476
72Chest pain (HP:0100749)2.20631617
73Severe combined immunodeficiency (HP:0004430)2.20361623
74Combined immunodeficiency (HP:0005387)2.19625832
75Abnormal gallbladder physiology (HP:0012438)2.19591436
76Cholecystitis (HP:0001082)2.19591436
77Joint swelling (HP:0001386)2.19561499
78Prolonged neonatal jaundice (HP:0006579)2.17865519
79Increased serum ferritin (HP:0003281)2.15139314
80Abnormality of eosinophils (HP:0001879)2.12958580
81Hemoptysis (HP:0002105)2.12698488
82Episodic fever (HP:0001954)2.10707817
83IgG deficiency (HP:0004315)2.10219924
84Colitis (HP:0002583)2.09968289
85Gangrene (HP:0100758)2.09203854
86Arterial thrombosis (HP:0004420)2.06090750
87Lymphoma (HP:0002665)2.02374648
88Gingivitis (HP:0000230)2.01569981
89Pulmonary fibrosis (HP:0002206)1.97856591
90Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97751672
91Supranuclear gaze palsy (HP:0000605)1.97719859
92Albinism (HP:0001022)1.97526938
93Malnutrition (HP:0004395)1.97481615
94Keratitis (HP:0000491)1.94331190
95Neuronal loss in central nervous system (HP:0002529)1.91229426
96Splenomegaly (HP:0001744)1.90439389
97Hypochromic anemia (HP:0001931)1.90011313
98Conjunctival telangiectasia (HP:0000524)1.88542627
99Abnormality of iron homeostasis (HP:0011031)1.86889293
100Amaurosis fugax (HP:0100576)1.86307766

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K134.48430129
2RIPK43.53442061
3MAP3K142.83671673
4MAP4K12.70328125
5ARAF2.61160437
6PRPF4B2.57622864
7TXK2.50287152
8IKBKE2.32111380
9BLK2.24748694
10ERN12.21864234
11TBK12.21556878
12TESK22.21146240
13IRAK42.06504351
14TYK21.99628838
15ZAP701.92621896
16CSK1.90442061
17MAP2K31.86829926
18SIK31.85990417
19BMPR21.77812144
20TAOK31.76933257
21TAOK21.66899928
22KSR21.64360461
23IKBKB1.62144405
24IRAK31.60042408
25SYK1.59802155
26JAK31.55729947
27GRK61.54890373
28BTK1.54267974
29MAP3K91.49515003
30CDK191.47678081
31MARK31.45140832
32MAP3K111.44437988
33MAP3K11.43311871
34CSF1R1.37323078
35MAP3K31.34279007
36RAF11.32046070
37TAOK11.27384801
38MOS1.21044606
39SCYL21.18528293
40FGR1.15064484
41MAP3K51.13847436
42FES1.13368820
43LYN1.12948072
44PIM11.10437815
45JAK11.08791662
46LCK1.06436970
47KIT1.03098155
48HCK1.02975975
49ITK1.02431353
50KSR11.00338306
51MAP3K120.99953929
52STK100.98511176
53MATK0.98194389
54BRAF0.97083042
55GRK70.95659929
56JAK20.94654179
57CDK120.92307238
58PDK10.91775498
59PIK3CG0.88608200
60PIM20.88228207
61TNK20.87271063
62TEC0.84991346
63CHUK0.76648310
64PRKCQ0.74013593
65MST40.72569319
66MAP3K80.67497783
67IRAK10.64671659
68STK240.63414983
69EPHB10.63183617
70NME20.57388609
71PDPK10.56396806
72CLK10.55711025
73MARK20.50936393
74PASK0.50869617
75SIK20.48520265
76MAP2K70.46732445
77TESK10.46235302
78DYRK1B0.42840231
79EPHA30.42107850
80MAPK110.41794994
81ACVR1B0.41515139
82TRIM280.39290128
83NEK60.37436777
84MAPKAPK20.36775484
85FYN0.36485445
86MAP3K40.35284565
87KDR0.35007629
88IRAK20.33855985
89LRRK20.32967659
90MAP3K60.30952606
91AURKA0.28502867
92PAK10.26747922
93CAMKK20.26666414
94EIF2AK30.24098569
95CAMKK10.22707346
96ABL10.21618404
97MAP3K20.21141139
98CDK40.20861380
99MAP2K40.20585794
100DYRK30.20330670

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.98900901
2Allograft rejection_Homo sapiens_hsa053302.58048666
3Graft-versus-host disease_Homo sapiens_hsa053322.53779443
4Osteoclast differentiation_Homo sapiens_hsa043802.51036060
5B cell receptor signaling pathway_Homo sapiens_hsa046622.45708518
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.45476257
7Leishmaniasis_Homo sapiens_hsa051402.42456162
8Autoimmune thyroid disease_Homo sapiens_hsa053202.38066234
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.37097811
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.32320384
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19727750
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03947023
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00850866
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.99080287
15Type I diabetes mellitus_Homo sapiens_hsa049401.93085479
16T cell receptor signaling pathway_Homo sapiens_hsa046601.90276916
17Tuberculosis_Homo sapiens_hsa051521.87588408
18Hematopoietic cell lineage_Homo sapiens_hsa046401.87007753
19Antigen processing and presentation_Homo sapiens_hsa046121.85683670
20Herpes simplex infection_Homo sapiens_hsa051681.85419096
21Measles_Homo sapiens_hsa051621.84878890
22Influenza A_Homo sapiens_hsa051641.80526031
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80025451
24TNF signaling pathway_Homo sapiens_hsa046681.75021529
25Staphylococcus aureus infection_Homo sapiens_hsa051501.70297726
26Shigellosis_Homo sapiens_hsa051311.65664128
27Rheumatoid arthritis_Homo sapiens_hsa053231.58511729
28Asthma_Homo sapiens_hsa053101.58140655
29Hepatitis B_Homo sapiens_hsa051611.57355831
30Toxoplasmosis_Homo sapiens_hsa051451.54973611
31Chemokine signaling pathway_Homo sapiens_hsa040621.51136506
32Viral myocarditis_Homo sapiens_hsa054161.50476209
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47339648
34Acute myeloid leukemia_Homo sapiens_hsa052211.46937104
35Malaria_Homo sapiens_hsa051441.45741586
36Legionellosis_Homo sapiens_hsa051341.41673205
37Phagosome_Homo sapiens_hsa041451.38583634
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36211199
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30675313
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.28032849
41Apoptosis_Homo sapiens_hsa042101.24303306
42Lysosome_Homo sapiens_hsa041421.23695310
43Salmonella infection_Homo sapiens_hsa051321.20818026
44Epstein-Barr virus infection_Homo sapiens_hsa051691.19705085
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18884495
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17665825
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15985224
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.14571651
49Dorso-ventral axis formation_Homo sapiens_hsa043201.12390111
50Other glycan degradation_Homo sapiens_hsa005111.10385790
51Viral carcinogenesis_Homo sapiens_hsa052031.08986712
52Hepatitis C_Homo sapiens_hsa051601.08474471
53Pertussis_Homo sapiens_hsa051331.06785354
54African trypanosomiasis_Homo sapiens_hsa051431.05868212
55Pancreatic cancer_Homo sapiens_hsa052121.03344182
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00928651
57Platelet activation_Homo sapiens_hsa046110.91688549
58Chronic myeloid leukemia_Homo sapiens_hsa052200.90076081
59Non-small cell lung cancer_Homo sapiens_hsa052230.84906563
60Collecting duct acid secretion_Homo sapiens_hsa049660.80926131
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80414515
62Regulation of autophagy_Homo sapiens_hsa041400.75956544
63Sphingolipid signaling pathway_Homo sapiens_hsa040710.68792409
64Endocytosis_Homo sapiens_hsa041440.68732303
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.65243342
66Renal cell carcinoma_Homo sapiens_hsa052110.64950847
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63679834
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62422740
69Prolactin signaling pathway_Homo sapiens_hsa049170.60989266
70HTLV-I infection_Homo sapiens_hsa051660.58730153
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.58703209
72FoxO signaling pathway_Homo sapiens_hsa040680.57749223
73VEGF signaling pathway_Homo sapiens_hsa043700.57551150
74Sulfur metabolism_Homo sapiens_hsa009200.49761329
75Inositol phosphate metabolism_Homo sapiens_hsa005620.47628326
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.43735539
77Basal transcription factors_Homo sapiens_hsa030220.42513872
78Systemic lupus erythematosus_Homo sapiens_hsa053220.40544413
79mTOR signaling pathway_Homo sapiens_hsa041500.39282790
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38594362
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37419961
82Pentose phosphate pathway_Homo sapiens_hsa000300.36428891
83Vibrio cholerae infection_Homo sapiens_hsa051100.34559391
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33658685
85MAPK signaling pathway_Homo sapiens_hsa040100.30588932
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30249340
87ErbB signaling pathway_Homo sapiens_hsa040120.27371331
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27032757
89Prion diseases_Homo sapiens_hsa050200.25601807
90Type II diabetes mellitus_Homo sapiens_hsa049300.24721470
91HIF-1 signaling pathway_Homo sapiens_hsa040660.24118999
92Endometrial cancer_Homo sapiens_hsa052130.22107227
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21619127
94Long-term depression_Homo sapiens_hsa047300.21041440
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.20465362
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.20369811
97Insulin resistance_Homo sapiens_hsa049310.19933129
98Choline metabolism in cancer_Homo sapiens_hsa052310.19305750
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19184095
100p53 signaling pathway_Homo sapiens_hsa041150.19156467

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