ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	GDP-mannose metabolic process (GO:0019673)	4.92454222
2	ribosomal small subunit biogenesis (GO:0042274)	4.67039822
3	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	4.66504626
4	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	4.34562899
5	protein maturation by protein folding (GO:0022417)	4.17741071
6	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.78452335
7	regulation of mitochondrial translation (GO:0070129)	3.75040916
8	purine deoxyribonucleotide catabolic process (GO:0009155)	3.70615641
9	viral transcription (GO:0019083)	3.59997743
10	deoxyribonucleotide catabolic process (GO:0009264)	3.54125980
11	NIK/NF-kappaB signaling (GO:0038061)	3.48041709
12	deoxyribose phosphate catabolic process (GO:0046386)	3.43242165
13	translational termination (GO:0006415)	3.27255256
14	nucleotide salvage (GO:0043173)	3.18324471
15	translational elongation (GO:0006414)	3.17247821
16	maturation of SSU-rRNA (GO:0030490)	3.15036017
17	base-excision repair, AP site formation (GO:0006285)	3.14706966
18	purine nucleotide salvage (GO:0032261)	3.12035948
19	pyrimidine nucleotide catabolic process (GO:0006244)	3.09506752
20	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.05879357
21	pseudouridine synthesis (GO:0001522)	3.05475237
22	pentose metabolic process (GO:0019321)	3.05443683
23	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.03460921
24	nuclear envelope reassembly (GO:0031468)	3.01295038
25	mitotic nuclear envelope reassembly (GO:0007084)	3.01295038
26	ribosomal small subunit assembly (GO:0000028)	3.01206055
27	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	3.00832518
28	guanosine-containing compound biosynthetic process (GO:1901070)	2.99720509
29	protein targeting to ER (GO:0045047)	2.97944780
30	negative regulation of B cell apoptotic process (GO:0002903)	2.96982013
31	viral life cycle (GO:0019058)	2.92955281
32	protein localization to endoplasmic reticulum (GO:0070972)	2.92739649
33	cotranslational protein targeting to membrane (GO:0006613)	2.91322306
34	UV protection (GO:0009650)	2.89602621
35	pyrimidine-containing compound salvage (GO:0008655)	2.86226508
36	pyrimidine nucleoside salvage (GO:0043097)	2.86226508
37	proteasome assembly (GO:0043248)	2.85964398
38	nucleoside salvage (GO:0043174)	2.83673318
39	protein targeting to mitochondrion (GO:0006626)	2.81789460
40	rRNA modification (GO:0000154)	2.81075498
41	positive regulation of T cell apoptotic process (GO:0070234)	2.79870864
42	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.79386055
43	proline biosynthetic process (GO:0006561)	2.79146681
44	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.78246393
45	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.77026611
46	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.75501977
47	ribonucleoprotein complex biogenesis (GO:0022613)	2.74301295
48	2-deoxyribonucleotide metabolic process (GO:0009394)	2.73908757
49	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.72828291
50	Golgi transport vesicle coating (GO:0048200)	2.70272825
51	COPI coating of Golgi vesicle (GO:0048205)	2.70272825
52	deoxyribose phosphate biosynthetic process (GO:0046385)	2.70001186
53	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.70001186
54	nucleobase-containing small molecule interconversion (GO:0015949)	2.69180065
55	establishment of protein localization to mitochondrion (GO:0072655)	2.68703381
56	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.67515496
57	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.66446836
58	metallo-sulfur cluster assembly (GO:0031163)	2.65450391
59	iron-sulfur cluster assembly (GO:0016226)	2.65450391
60	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.65368381
61	DNA deamination (GO:0045006)	2.63612793
62	UTP biosynthetic process (GO:0006228)	2.63031286
63	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.61658689
64	deoxyribose phosphate metabolic process (GO:0019692)	2.61348246
65	transcription from mitochondrial promoter (GO:0006390)	2.61066658
66	chaperone-mediated protein transport (GO:0072321)	2.60796072
67	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.60342429
68	ATP synthesis coupled proton transport (GO:0015986)	2.60342429
69	protein complex biogenesis (GO:0070271)	2.58932324
70	GTP biosynthetic process (GO:0006183)	2.58289747
71	peptidyl-arginine omega-N-methylation (GO:0035247)	2.58065715
72	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.57907174
73	negative regulation of ligase activity (GO:0051352)	2.57023104
74	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57023104
75	oxidative phosphorylation (GO:0006119)	2.56852003
76	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.56451159
77	cellular protein complex disassembly (GO:0043624)	2.55241713
78	amino sugar catabolic process (GO:0046348)	2.54562036
79	cellular component biogenesis (GO:0044085)	2.52758523
80	translation (GO:0006412)	2.52652449
81	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.52504394
82	pinocytosis (GO:0006907)	2.52213947
83	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48998029
84	termination of RNA polymerase III transcription (GO:0006386)	2.48998029
85	folic acid metabolic process (GO:0046655)	2.48472535
86	purine deoxyribonucleotide metabolic process (GO:0009151)	2.47932644
87	modulation by virus of host process (GO:0019054)	2.46934539
88	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.45654080
89	tRNA methylation (GO:0030488)	2.43820236
90	ribosomal large subunit biogenesis (GO:0042273)	2.42871297
91	respiratory electron transport chain (GO:0022904)	2.41722374
92	rRNA transcription (GO:0009303)	2.40322566
93	protein retention in ER lumen (GO:0006621)	2.40264465
94	regulation of mitochondrial membrane potential (GO:0051881)	2.40006102
95	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.39947366
96	regulation of translational termination (GO:0006449)	2.39433687
97	regulation of superoxide anion generation (GO:0032928)	2.39064442
98	negative regulation of cell size (GO:0045792)	2.38755946
99	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.37929716
100	translational initiation (GO:0006413)	2.37873230

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.07002848
2	* VDR_21846776_ChIP-Seq_THP-1_Human	2.73752740
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.73277600
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57292198
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.50981762
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.31996062
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.24545798
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.23576944
9	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.22694592
10	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.20095145
11	* LXR_22292898_ChIP-Seq_THP-1_Human	2.10493015
12	MYC_22102868_ChIP-Seq_BL_Human	2.08813327
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.98909828
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95652118
15	* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.90106319
16	XRN2_22483619_ChIP-Seq_HELA_Human	1.89959926
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.87479586
18	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.85591221
19	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.83389094
20	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.73162046
21	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.71491757
22	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.69364468
23	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.68080147
24	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.65428195
25	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.63626016
26	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.62105659
27	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.61927244
28	E2F7_22180533_ChIP-Seq_HELA_Human	1.60971083
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.60929300
30	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.60679756
31	P68_20966046_ChIP-Seq_HELA_Human	1.60196838
32	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.57653263
33	ZNF263_19887448_ChIP-Seq_K562_Human	1.57481913
34	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.55844067
35	* DCP1A_22483619_ChIP-Seq_HELA_Human	1.55294545
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.55221954
37	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.54290366
38	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.53412802
39	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.52569715
40	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.51489879
41	RACK7_27058665_Chip-Seq_MCF-7_Human	1.50786945
42	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.50499780
43	MAF_26560356_Chip-Seq_TH2_Human	1.50054115
44	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.49942123
45	BCL6_27268052_Chip-Seq_Bcells_Human	1.47520781
46	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.44271202
47	* VDR_24763502_ChIP-Seq_THP-1_Human	1.41437372
48	MAF_26560356_Chip-Seq_TH1_Human	1.40325240
49	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.39982253
50	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.39682020
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.38928770
52	BCOR_27268052_Chip-Seq_Bcells_Human	1.38797096
53	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.37733893
54	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.37206964
55	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.35661660
56	UTX_26944678_Chip-Seq_JUKART_Human	1.33647772
57	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.32516750
58	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.29914723
59	CIITA_25753668_ChIP-Seq_RAJI_Human	1.29467628
60	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25732949
61	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.24711785
62	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.23886307
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23816904
64	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.23620121
65	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.23449233
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.23334498
67	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.23187537
68	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.23058250
69	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.22926261
70	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.21835868
71	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.21023536
72	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.19741001
73	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17702900
74	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.17084019
75	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.16810809
76	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.15702095
77	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.15550846
78	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.15344054
79	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.14219451
80	FOXP3_21729870_ChIP-Seq_TREG_Human	1.13809145
81	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.13764766
82	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13750992
83	* KDM2B_26808549_Chip-Seq_DND41_Human	1.13177793
84	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.13108175
85	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.12188266
86	* PHF8_20622854_ChIP-Seq_HELA_Human	1.11054012
87	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.10960214
88	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.10639561
89	E2F1_20622854_ChIP-Seq_HELA_Human	1.10459792
90	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.10052963
91	TTF2_22483619_ChIP-Seq_HELA_Human	1.09965773
92	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09631537
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09594934
94	* TFEB_21752829_ChIP-Seq_HELA_Human	1.09310736
95	CTCF_21964334_Chip-Seq_Bcells_Human	1.08809902
96	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08445177
97	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.08257219
98	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.07966418
99	SPI1_23547873_ChIP-Seq_NB4_Human	1.07883213
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.06838387

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	3.87038334
2	MP0003806_abnormal_nucleotide_metabolis	3.46725495
3	MP0005451_abnormal_body_composition	3.37482496
4	MP0009333_abnormal_splenocyte_physiolog	3.11481757
5	MP0009840_abnormal_foam_cell	2.55402336
6	MP0003436_decreased_susceptibility_to	2.53403996
7	MP0008260_abnormal_autophagy	2.19073024
8	MP0005671_abnormal_response_to	2.12272739
9	MP0002148_abnormal_hypersensitivity_rea	2.09435077
10	MP0004185_abnormal_adipocyte_glucose	2.03341226
11	MP0005025_abnormal_response_to	2.01456471
12	MP0001835_abnormal_antigen_presentation	1.99800941
13	MP0003191_abnormal_cellular_cholesterol	1.97835084
14	MP0003763_abnormal_thymus_physiology	1.94042469
15	MP0000685_abnormal_immune_system	1.91023949
16	MP0003693_abnormal_embryo_hatching	1.86268380
17	MP0005000_abnormal_immune_tolerance	1.82767668
18	MP0001853_heart_inflammation	1.81962421
19	MP0009785_altered_susceptibility_to	1.81555093
20	MP0000858_altered_metastatic_potential	1.75675151
21	MP0003303_peritoneal_inflammation	1.72967450
22	MP0002723_abnormal_immune_serum	1.71054981
23	MP0001873_stomach_inflammation	1.70560426
24	MP0003186_abnormal_redox_activity	1.68411664
25	MP0006036_abnormal_mitochondrial_physio	1.67645415
26	MP0002420_abnormal_adaptive_immunity	1.66630015
27	MP0001819_abnormal_immune_cell	1.66617491
28	MP0002419_abnormal_innate_immunity	1.60325330
29	MP0002452_abnormal_antigen_presenting	1.60278409
30	MP0001661_extended_life_span	1.58681603
31	MP0003111_abnormal_nucleus_morphology	1.58274709
32	MP0005387_immune_system_phenotype	1.57253462
33	MP0001790_abnormal_immune_system	1.57253462
34	MP0001800_abnormal_humoral_immune	1.56956802
35	MP0000490_abnormal_crypts_of	1.56337624
36	MP0005464_abnormal_platelet_physiology	1.55606491
37	MP0003786_premature_aging	1.54383903
38	MP0006082_CNS_inflammation	1.49691408
39	MP0002398_abnormal_bone_marrow	1.48985996
40	MP0002877_abnormal_melanocyte_morpholog	1.48219078
41	MP0000343_altered_response_to	1.43755719
42	MP0000716_abnormal_immune_system	1.42559065
43	MP0005670_abnormal_white_adipose	1.42103129
44	MP0002429_abnormal_blood_cell	1.40919231
45	MP0003172_abnormal_lysosome_physiology	1.37893420
46	MP0002722_abnormal_immune_system	1.37801350
47	MP0009278_abnormal_bone_marrow	1.34745046
48	MP0000678_abnormal_parathyroid_gland	1.34735363
49	MP0005501_abnormal_skin_physiology	1.32904223
50	MP0009379_abnormal_foot_pigmentation	1.31195293
51	MP0003075_altered_response_to	1.30992462
52	MP0001845_abnormal_inflammatory_respons	1.30971070
53	MP0004947_skin_inflammation	1.30097703
54	MP0010155_abnormal_intestine_physiology	1.26795765
55	MP0008469_abnormal_protein_level	1.26562660
56	MP0000689_abnormal_spleen_morphology	1.26416411
57	MP0003077_abnormal_cell_cycle	1.24850353
58	MP0000703_abnormal_thymus_morphology	1.24624709
59	MP0002405_respiratory_system_inflammati	1.22111869
60	MP0003453_abnormal_keratinocyte_physiol	1.20232932
61	MP0005666_abnormal_adipose_tissue	1.16545528
62	MP0004957_abnormal_blastocyst_morpholog	1.16484172
63	MP0005360_urolithiasis	1.15735182
64	MP0002132_abnormal_respiratory_system	1.12557020
65	MP0002019_abnormal_tumor_incidence	1.11159464
66	MP0004858_abnormal_nervous_system	1.10760099
67	MP0006035_abnormal_mitochondrial_morpho	1.07668694
68	MP0000358_abnormal_cell_content/	1.04954980
69	MP0000313_abnormal_cell_death	1.04914162
70	MP0001533_abnormal_skeleton_physiology	1.04620721
71	MP0005584_abnormal_enzyme/coenzyme_acti	1.03147204
72	MP0000750_abnormal_muscle_regeneration	1.00879416
73	MP0003448_altered_tumor_morphology	0.95131463
74	MP0001764_abnormal_homeostasis	0.94841917
75	MP0003705_abnormal_hypodermis_morpholog	0.94711509
76	MP0005310_abnormal_salivary_gland	0.93920453
77	MP0005330_cardiomyopathy	0.93718555
78	MP0002796_impaired_skin_barrier	0.93449531
79	MP0005083_abnormal_biliary_tract	0.93236668
80	MP0002139_abnormal_hepatobiliary_system	0.92939816
81	MP0004510_myositis	0.91197551
82	MP0008007_abnormal_cellular_replicative	0.90380187
83	MP0001545_abnormal_hematopoietic_system	0.87371512
84	MP0005397_hematopoietic_system_phenotyp	0.87371512
85	MP0009764_decreased_sensitivity_to	0.84515195
86	MP0001542_abnormal_bone_strength	0.84489330
87	MP0005166_decreased_susceptibility_to	0.83637788
88	MP0009643_abnormal_urine_homeostasis	0.83532144
89	MP0003866_abnormal_defecation	0.82672858
90	MP0005375_adipose_tissue_phenotype	0.82120336
91	MP0005165_increased_susceptibility_to	0.79784539
92	MP0000681_abnormal_thyroid_gland	0.79385530
93	MP0005319_abnormal_enzyme/_coenzyme	0.78888257
94	MP0005076_abnormal_cell_differentiation	0.78323023
95	MP0001663_abnormal_digestive_system	0.76119524
96	MP0000609_abnormal_liver_physiology	0.75447190
97	MP0008058_abnormal_DNA_repair	0.75092458
98	MP0002396_abnormal_hematopoietic_system	0.74893862
99	MP0001881_abnormal_mammary_gland	0.74705892
100	MP0009931_abnormal_skin_appearance	0.73135799

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Testicular atrophy (HP:0000029)	3.61503384
2	Abnormality of glycolipid metabolism (HP:0010969)	3.37072575
3	Abnormality of liposaccharide metabolism (HP:0010968)	3.37072575
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.37072575
5	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.36315159
6	Microvesicular hepatic steatosis (HP:0001414)	3.30652168
7	Increased muscle lipid content (HP:0009058)	3.18793861
8	Increased intramyocellular lipid droplets (HP:0012240)	3.14571321
9	Vertebral compression fractures (HP:0002953)	3.12135790
10	Mitochondrial inheritance (HP:0001427)	3.07096813
11	Hepatocellular necrosis (HP:0001404)	3.00894327
12	Abnormal mitochondria in muscle tissue (HP:0008316)	2.99621686
13	Ragged-red muscle fibers (HP:0003200)	2.85662152
14	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.75222124
15	Increased cerebral lipofuscin (HP:0011813)	2.74698882
16	Acute necrotizing encephalopathy (HP:0006965)	2.72054970
17	Hypertensive crisis (HP:0100735)	2.71759572
18	Petechiae (HP:0000967)	2.67744155
19	Abnormal number of erythroid precursors (HP:0012131)	2.67314302
20	Renal Fanconi syndrome (HP:0001994)	2.66601909
21	Progressive muscle weakness (HP:0003323)	2.63853483
22	Dysostosis multiplex (HP:0000943)	2.63403790
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.63211816
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.63211816
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.61937198
26	Rough bone trabeculation (HP:0100670)	2.58809184
27	Abnormality of cells of the erythroid lineage (HP:0012130)	2.58746900
28	Hepatic necrosis (HP:0002605)	2.58581280
29	Obstructive lung disease (HP:0006536)	2.58475257
30	Chronic obstructive pulmonary disease (HP:0006510)	2.58475257
31	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.56438087
32	Type I transferrin isoform profile (HP:0003642)	2.56016893
33	Increased CSF lactate (HP:0002490)	2.55560694
34	Acute encephalopathy (HP:0006846)	2.46810252
35	Dicarboxylic aciduria (HP:0003215)	2.44656447
36	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.44656447
37	Prolonged neonatal jaundice (HP:0006579)	2.43887324
38	Purpura (HP:0000979)	2.42171982
39	Hepatosplenomegaly (HP:0001433)	2.41036955
40	Microretrognathia (HP:0000308)	2.38439447
41	Increased hepatocellular lipid droplets (HP:0006565)	2.37765361
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.35652230
43	Increased serum ferritin (HP:0003281)	2.32784737
44	Thrombocytosis (HP:0001894)	2.32111509
45	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.30740618
46	Lipid accumulation in hepatocytes (HP:0006561)	2.29006673
47	Exercise intolerance (HP:0003546)	2.27806310
48	Achilles tendon contracture (HP:0001771)	2.24651826
49	Lactic acidosis (HP:0003128)	2.24468669
50	Abnormal trabecular bone morphology (HP:0100671)	2.23495292
51	Progressive neurologic deterioration (HP:0002344)	2.21259855
52	Abnormality of macrophages (HP:0004311)	2.19789611
53	Vacuolated lymphocytes (HP:0001922)	2.15711929
54	Increased serum lactate (HP:0002151)	2.11270183
55	Recurrent abscess formation (HP:0002722)	2.11223782
56	Respiratory difficulties (HP:0002880)	2.08444812
57	Trismus (HP:0000211)	2.08292820
58	Hypokinesia (HP:0002375)	2.06152822
59	Abnormality of polysaccharide metabolism (HP:0011012)	2.05347995
60	Abnormality of glycosaminoglycan metabolism (HP:0004371)	2.05347995
61	Abnormality of mucopolysaccharide metabolism (HP:0011020)	2.05347995
62	Mediastinal lymphadenopathy (HP:0100721)	2.05089164
63	Cerebral edema (HP:0002181)	2.05008016
64	Loss of speech (HP:0002371)	2.01966102
65	Eczematoid dermatitis (HP:0000976)	2.01872278
66	Axonal loss (HP:0003447)	1.99494145
67	Abnormal glycosylation (HP:0012345)	1.98185118
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.98185118
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.98185118
70	Abnormal protein glycosylation (HP:0012346)	1.98185118
71	Squamous cell carcinoma (HP:0002860)	1.97958306
72	Abnormality of the Achilles tendon (HP:0005109)	1.96833545
73	Reticulocytopenia (HP:0001896)	1.96606327
74	Recurrent bacterial skin infections (HP:0005406)	1.95767352
75	Gastrointestinal stroma tumor (HP:0100723)	1.95379608
76	Broad distal phalanx of finger (HP:0009836)	1.94308290
77	Myopathic facies (HP:0002058)	1.93973716
78	Progressive macrocephaly (HP:0004481)	1.93128153
79	Seborrheic dermatitis (HP:0001051)	1.90544617
80	Reduced subcutaneous adipose tissue (HP:0003758)	1.89737713
81	Multiple enchondromatosis (HP:0005701)	1.89155944
82	Cutaneous melanoma (HP:0012056)	1.89032501
83	Opisthotonus (HP:0002179)	1.88839444
84	Agammaglobulinemia (HP:0004432)	1.86955890
85	Systemic lupus erythematosus (HP:0002725)	1.85514930
86	Spastic paraparesis (HP:0002313)	1.83016763
87	Pancytopenia (HP:0001876)	1.82660939
88	Urinary glycosaminoglycan excretion (HP:0003541)	1.81979634
89	Mucopolysacchariduria (HP:0008155)	1.81979634
90	Joint stiffness (HP:0001387)	1.81017336
91	Reduced antithrombin III activity (HP:0001976)	1.79723942
92	Esophageal neoplasm (HP:0100751)	1.78617246
93	Neoplasm of head and neck (HP:0012288)	1.78617246
94	Recurrent viral infections (HP:0004429)	1.78252767
95	Cellulitis (HP:0100658)	1.77230235
96	Hypertriglyceridemia (HP:0002155)	1.77101565
97	Respiratory failure (HP:0002878)	1.76750863
98	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.76645714
99	Bulbar palsy (HP:0001283)	1.76442710
100	Exertional dyspnea (HP:0002875)	1.76017605

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.27428653
2	TESK2	4.26398742
3	VRK2	3.98600404
4	ERN1	3.07172040
5	TESK1	2.96319310
6	IRAK3	2.79214895
7	SMG1	2.72420207
8	ARAF	2.52688256
9	PIM2	2.45905509
10	MAP3K11	2.38490534
11	KDR	2.37054647
12	BCKDK	2.19913104
13	TRIB3	2.15421766
14	BUB1	2.11909250
15	MAP4K1	1.99115738
16	TAOK2	1.95067754
17	PRPF4B	1.76556350
18	LIMK1	1.58577527
19	SIK1	1.57527197
20	TBK1	1.50541633
21	MAP2K3	1.48858756
22	SCYL2	1.45815162
23	STK16	1.43254390
24	ABL2	1.40850514
25	TLK1	1.32545229
26	BRAF	1.16767333
27	ICK	1.08176334
28	MAPKAPK3	1.05254915
29	EPHA2	1.04718867
30	IKBKB	1.04296985
31	PRKD2	1.04027727
32	MAP3K3	1.03478833
33	AURKA	1.03067840
34	GRK6	0.99936004
35	LRRK2	0.97979851
36	PAK4	0.93375819
37	NME1	0.91107431
38	IRAK4	0.89114730
39	TAOK1	0.88048690
40	BLK	0.84842381
41	DAPK1	0.84429392
42	TYK2	0.84099335
43	ZAP70	0.81043864
44	ILK	0.80333089
45	IKBKE	0.78081513
46	VRK1	0.77040457
47	MAP3K8	0.76762622
48	JAK3	0.74911895
49	IRAK2	0.73281293
50	MST1R	0.72969438
51	PRKD3	0.72144085
52	MAP3K13	0.71241563
53	MAPK11	0.70273748
54	PRKCI	0.67665093
55	CDK4	0.66389383
56	CDK7	0.66379883
57	TNK2	0.66128954
58	SIK3	0.66088596
59	DAPK3	0.64429809
60	PAK1	0.63613644
61	EEF2K	0.61893710
62	PBK	0.60766118
63	RPS6KB2	0.59045608
64	TXK	0.58604850
65	MAP2K2	0.56366553
66	CDK8	0.55998459
67	MAP3K1	0.55671288
68	STK10	0.55295239
69	PDPK1	0.54728255
70	PDK2	0.53769923
71	RPS6KA5	0.48826470
72	TAF1	0.48448083
73	CDK9	0.44018693
74	MOS	0.40619802
75	MAP3K14	0.40421767
76	CSK	0.39582788
77	MAPKAPK2	0.38747388
78	LMTK2	0.38015506
79	CSF1R	0.36571810
80	RPS6KL1	0.35615028
81	RPS6KC1	0.35615028
82	PIM1	0.35517900
83	BTK	0.35307159
84	CHEK2	0.34951713
85	HIPK2	0.33845355
86	CDC7	0.33676007
87	AURKB	0.32923490
88	PRKG2	0.31052928
89	FES	0.30198115
90	BMX	0.30068228
91	LYN	0.30056110
92	MAP3K10	0.29373194
93	SYK	0.28919691
94	CSNK1G3	0.28674930
95	AKT2	0.28123628
96	LCK	0.27837692
97	PTK6	0.26742510
98	CCNB1	0.26481196
99	RPS6KA2	0.26250276
100	MAP2K6	0.25939013

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.83070191
2	Sulfur relay system_Homo sapiens_hsa04122	3.55090093
3	Proteasome_Homo sapiens_hsa03050	3.33044462
4	DNA replication_Homo sapiens_hsa03030	2.91789276
5	Base excision repair_Homo sapiens_hsa03410	2.66093983
6	Other glycan degradation_Homo sapiens_hsa00511	2.57372083
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.52002964
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.12846269
9	Pyrimidine metabolism_Homo sapiens_hsa00240	2.12494756
10	RNA polymerase_Homo sapiens_hsa03020	2.08260384
11	Parkinsons disease_Homo sapiens_hsa05012	2.07099295
12	Primary immunodeficiency_Homo sapiens_hsa05340	2.04908901
13	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.87246116
14	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.75136159
15	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.74134525
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.63637546
17	Huntingtons disease_Homo sapiens_hsa05016	1.51788909
18	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.49947536
19	Folate biosynthesis_Homo sapiens_hsa00790	1.49795369
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.46077206
21	Mismatch repair_Homo sapiens_hsa03430	1.42394523
22	Lysosome_Homo sapiens_hsa04142	1.41677472
23	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.40233792
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39877190
25	Spliceosome_Homo sapiens_hsa03040	1.38690071
26	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.36990847
27	Glutathione metabolism_Homo sapiens_hsa00480	1.36605837
28	Sulfur metabolism_Homo sapiens_hsa00920	1.36392073
29	Galactose metabolism_Homo sapiens_hsa00052	1.35150441
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34166776
31	Antigen processing and presentation_Homo sapiens_hsa04612	1.31317546
32	Alzheimers disease_Homo sapiens_hsa05010	1.27991168
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27367035
34	Allograft rejection_Homo sapiens_hsa05330	1.24126827
35	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16560941
36	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.14832097
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.10043827
38	Graft-versus-host disease_Homo sapiens_hsa05332	1.08526869
39	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03041900
40	Nucleotide excision repair_Homo sapiens_hsa03420	1.00911571
41	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.98715732
42	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.97999281
43	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.96316002
44	Bladder cancer_Homo sapiens_hsa05219	0.95654086
45	Fatty acid elongation_Homo sapiens_hsa00062	0.94921251
46	Shigellosis_Homo sapiens_hsa05131	0.94800576
47	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.92903066
48	Herpes simplex infection_Homo sapiens_hsa05168	0.92161488
49	Carbon metabolism_Homo sapiens_hsa01200	0.92050553
50	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90930655
51	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.89517721
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.89379928
53	Homologous recombination_Homo sapiens_hsa03440	0.89157567
54	Phenylalanine metabolism_Homo sapiens_hsa00360	0.87617458
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.84361871
56	Prion diseases_Homo sapiens_hsa05020	0.84022759
57	Purine metabolism_Homo sapiens_hsa00230	0.83496814
58	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.81888804
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.81395690
60	Apoptosis_Homo sapiens_hsa04210	0.79927814
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.78529168
62	Asthma_Homo sapiens_hsa05310	0.78406739
63	Viral myocarditis_Homo sapiens_hsa05416	0.77800925
64	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75839810
65	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.73359749
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73239551
67	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69995713
68	Leishmaniasis_Homo sapiens_hsa05140	0.69845111
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.68077020
70	Osteoclast differentiation_Homo sapiens_hsa04380	0.65482074
71	HTLV-I infection_Homo sapiens_hsa05166	0.64894117
72	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.63949895
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63908509
74	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.61170021
75	Type I diabetes mellitus_Homo sapiens_hsa04940	0.59371018
76	Metabolic pathways_Homo sapiens_hsa01100	0.59360306
77	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.56582522
78	Salmonella infection_Homo sapiens_hsa05132	0.56088644
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55865454
80	Tuberculosis_Homo sapiens_hsa05152	0.55508593
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54830349
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.54204661
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.53112969
84	One carbon pool by folate_Homo sapiens_hsa00670	0.51972585
85	Influenza A_Homo sapiens_hsa05164	0.49134080
86	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48535796
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48116563
88	Measles_Homo sapiens_hsa05162	0.47238418
89	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.45444375
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.43634668
91	Viral carcinogenesis_Homo sapiens_hsa05203	0.41695433
92	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.39244606
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.37553158
94	Peroxisome_Homo sapiens_hsa04146	0.37486114
95	Phagosome_Homo sapiens_hsa04145	0.36792496
96	TNF signaling pathway_Homo sapiens_hsa04668	0.36504847
97	Pertussis_Homo sapiens_hsa05133	0.35148550
98	Fanconi anemia pathway_Homo sapiens_hsa03460	0.34120442
99	RNA transport_Homo sapiens_hsa03013	0.31979442
100	Legionellosis_Homo sapiens_hsa05134	0.31390846

C19ORF24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »