C19ORF33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.73475923
2hemidesmosome assembly (GO:0031581)5.59448402
3negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.93641049
4GDP-mannose metabolic process (GO:0019673)4.72370804
5protein maturation by protein folding (GO:0022417)4.51568004
6positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.19099316
7regulation of metalloenzyme activity (GO:0048552)4.16835314
8regulation of water loss via skin (GO:0033561)4.16001677
9establishment of skin barrier (GO:0061436)4.11064285
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.05263929
11Golgi transport vesicle coating (GO:0048200)4.00685875
12COPI coating of Golgi vesicle (GO:0048205)4.00685875
13positive regulation of Cdc42 GTPase activity (GO:0043089)3.97519828
14nuclear envelope reassembly (GO:0031468)3.74297185
15mitotic nuclear envelope reassembly (GO:0007084)3.74297185
16nucleobase-containing small molecule interconversion (GO:0015949)3.67030040
17negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.61941014
18positive regulation of epidermal cell differentiation (GO:0045606)3.58382038
19membrane raft organization (GO:0031579)3.51011850
20protein retention in ER lumen (GO:0006621)3.50305326
21multicellular organismal water homeostasis (GO:0050891)3.50014556
22positive regulation of pseudopodium assembly (GO:0031274)3.47057615
23maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38153957
24cyclooxygenase pathway (GO:0019371)3.27645299
25nucleoside diphosphate biosynthetic process (GO:0009133)3.23739458
26negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.23564846
27glucose catabolic process (GO:0006007)3.19873856
28proteasome assembly (GO:0043248)3.15778882
29polyketide metabolic process (GO:0030638)3.15544950
30doxorubicin metabolic process (GO:0044598)3.15544950
31daunorubicin metabolic process (GO:0044597)3.15544950
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14128208
33keratinocyte proliferation (GO:0043616)3.08126057
34establishment of integrated proviral latency (GO:0075713)3.04998748
35pyrimidine-containing compound salvage (GO:0008655)3.04162823
36pyrimidine nucleoside salvage (GO:0043097)3.04162823
37regulation of pseudopodium assembly (GO:0031272)3.01282509
38nucleotide-sugar biosynthetic process (GO:0009226)3.00239927
39hypotonic response (GO:0006971)2.99899882
40establishment of viral latency (GO:0019043)2.97015135
41epithelial cell-cell adhesion (GO:0090136)2.95853447
42muscle cell migration (GO:0014812)2.95251107
43pentose-phosphate shunt (GO:0006098)2.95194477
44positive regulation of epidermis development (GO:0045684)2.93423707
45prostanoid biosynthetic process (GO:0046457)2.92741708
46prostaglandin biosynthetic process (GO:0001516)2.92741708
47lipoxygenase pathway (GO:0019372)2.92085860
48ribosomal small subunit biogenesis (GO:0042274)2.91739755
49activation of Rac GTPase activity (GO:0032863)2.91727661
50primary alcohol catabolic process (GO:0034310)2.84880107
51proline biosynthetic process (GO:0006561)2.81138793
52membrane budding (GO:0006900)2.80663926
53water homeostasis (GO:0030104)2.79906183
54ribosome assembly (GO:0042255)2.79872817
55aminoglycoside antibiotic metabolic process (GO:0030647)2.78472032
56nucleoside salvage (GO:0043174)2.76907357
57cell-substrate junction assembly (GO:0007044)2.74379531
58NADH metabolic process (GO:0006734)2.72888359
59barbed-end actin filament capping (GO:0051016)2.72111636
60mitochondrial calcium ion transport (GO:0006851)2.70310952
61regulation of cellular amino acid metabolic process (GO:0006521)2.67576947
62endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.67125158
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65154239
64L-phenylalanine metabolic process (GO:0006558)2.65154239
65prostanoid metabolic process (GO:0006692)2.63184616
66prostaglandin metabolic process (GO:0006693)2.63184616
67gap junction assembly (GO:0016264)2.61096310
68positive regulation of keratinocyte differentiation (GO:0045618)2.59636481
69tight junction assembly (GO:0070830)2.59200254
70actin filament depolymerization (GO:0030042)2.59075401
71positive regulation of actin filament depolymerization (GO:0030836)2.58693457
72NADPH regeneration (GO:0006740)2.57397939
73keratinization (GO:0031424)2.57386481
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55994859
75extracellular fibril organization (GO:0043206)2.55975998
76regulation of apoptotic process involved in morphogenesis (GO:1902337)2.52687326
772-deoxyribonucleotide biosynthetic process (GO:0009265)2.51844351
78deoxyribose phosphate biosynthetic process (GO:0046385)2.51844351
79hydrogen peroxide catabolic process (GO:0042744)2.51306373
80type B pancreatic cell proliferation (GO:0044342)2.49788322
81skin morphogenesis (GO:0043589)2.48448483
82diterpenoid biosynthetic process (GO:0016102)2.47446371
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.47240555
84ribosomal large subunit biogenesis (GO:0042273)2.46609586
85mesodermal cell differentiation (GO:0048333)2.45343284
86cellular copper ion homeostasis (GO:0006878)2.45225209
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.44841847
88galactose catabolic process (GO:0019388)2.42881813
89glycoside metabolic process (GO:0016137)2.42828745
90glutathione derivative biosynthetic process (GO:1901687)2.42552471
91glutathione derivative metabolic process (GO:1901685)2.42552471
92citrulline biosynthetic process (GO:0019240)2.42273985
93negative regulation of ligase activity (GO:0051352)2.40308960
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40308960
95positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.39728197
96urea cycle (GO:0000050)2.36601584
97cellular response to zinc ion (GO:0071294)2.36395911
98regulation of mitochondrial translation (GO:0070129)2.36395568
99regulation of keratinocyte differentiation (GO:0045616)2.36197345
100regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.36126703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.80672334
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.09884679
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.89742585
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.26332339
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.23572591
6ZNF263_19887448_ChIP-Seq_K562_Human3.00230554
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60416797
8KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.18790288
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16044600
10RACK7_27058665_Chip-Seq_MCF-7_Human2.09527897
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04059139
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.02419599
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.02419599
14* ATF3_27146783_Chip-Seq_COLON_Human1.93326789
15ESR2_21235772_ChIP-Seq_MCF-7_Human1.93321477
16KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.89432043
17SRY_22984422_ChIP-ChIP_TESTIS_Rat1.88922455
18* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.86093669
19ELK3_25401928_ChIP-Seq_HUVEC_Human1.84828885
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.80053810
21CDX2_20551321_ChIP-Seq_CACO-2_Human1.75848609
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75798900
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.75489465
24KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68305053
25P63_26484246_Chip-Seq_KERATINOCYTES_Human1.67593611
26HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.67122016
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.66962053
28ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.62557353
29MYC_18358816_ChIP-ChIP_MESCs_Mouse1.61776160
30LXR_22292898_ChIP-Seq_THP-1_Human1.60864533
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60154559
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.59170488
33* SOX2_20726797_ChIP-Seq_SW620_Human1.55597684
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.50544628
35* GATA6_25053715_ChIP-Seq_YYC3_Human1.49655195
36ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48093024
37DCP1A_22483619_ChIP-Seq_HELA_Human1.46896806
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45424206
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45341357
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.44393185
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44058651
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43506751
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42744857
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.42742372
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.36291986
46CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33137430
47* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32841473
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30019033
49AR_21909140_ChIP-Seq_LNCAP_Human1.29311100
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29248067
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26118846
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25606005
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25497895
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24894742
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24860316
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24818335
57TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24600411
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23671459
59CLOCK_20551151_ChIP-Seq_293T_Human1.21647275
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.21274971
61MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20222723
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20082824
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19537226
64GATA4_25053715_ChIP-Seq_YYC3_Human1.18845984
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17705208
66XRN2_22483619_ChIP-Seq_HELA_Human1.15097056
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14386847
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.10052181
69PPARA_22158963_ChIP-Seq_LIVER_Mouse1.07398321
70* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07393792
71PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07382066
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07268824
73P68_20966046_ChIP-Seq_HELA_Human1.06986557
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05007536
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.04828185
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.04554653
77* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04462968
78BCOR_27268052_Chip-Seq_Bcells_Human1.03874801
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03671186
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00751953
81P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99794190
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99526077
83* TP63_22573176_ChIP-Seq_HFKS_Human0.99148641
84* KLF5_25053715_ChIP-Seq_YYC3_Human0.98959319
85GABP_17652178_ChIP-ChIP_JURKAT_Human0.98775158
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97591855
87ELF5_23300383_ChIP-Seq_T47D_Human0.97360029
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96540571
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96502048
90TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.96462145
91UBF1/2_26484160_Chip-Seq_HMECs_Human0.95771417
92* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95734000
93GABP_19822575_ChIP-Seq_HepG2_Human0.95583622
94KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94834093
95VDR_21846776_ChIP-Seq_THP-1_Human0.94607069
96CTCF_18555785_ChIP-Seq_MESCs_Mouse0.93169545
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91258480
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90445935
99BCL6_27268052_Chip-Seq_Bcells_Human0.89902440
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89415415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.55393770
2MP0002796_impaired_skin_barrier3.83689701
3MP0005501_abnormal_skin_physiology3.07501778
4MP0003806_abnormal_nucleotide_metabolis2.97612905
5MP0003191_abnormal_cellular_cholesterol2.77815273
6MP0003566_abnormal_cell_adhesion2.71570573
7MP0003453_abnormal_keratinocyte_physiol2.65009610
8MP0005360_urolithiasis2.64406058
9MP0000579_abnormal_nail_morphology2.52213573
10MP0002877_abnormal_melanocyte_morpholog2.46277038
11MP0004264_abnormal_extraembryonic_tissu2.38013144
12MP0001216_abnormal_epidermal_layer2.22191146
13MP0010678_abnormal_skin_adnexa2.13655343
14MP0000762_abnormal_tongue_morphology2.11243333
15MP0005083_abnormal_biliary_tract2.09459892
16MP0002060_abnormal_skin_morphology1.99494567
17MP0003705_abnormal_hypodermis_morpholog1.96692558
18MP0005451_abnormal_body_composition1.93726806
19MP0000467_abnormal_esophagus_morphology1.88776564
20MP0010030_abnormal_orbit_morphology1.88031646
21MP0005023_abnormal_wound_healing1.87952648
22MP0009379_abnormal_foot_pigmentation1.85468988
23MP0010352_gastrointestinal_tract_polyps1.84861617
24MP0009053_abnormal_anal_canal1.84710574
25MP0003950_abnormal_plasma_membrane1.80989367
26MP0010771_integument_phenotype1.79328872
27MP0008875_abnormal_xenobiotic_pharmacok1.74565054
28MP0009780_abnormal_chondrocyte_physiolo1.73582672
29MP0005464_abnormal_platelet_physiology1.68758967
30MP0000858_altered_metastatic_potential1.66689222
31MP0002098_abnormal_vibrissa_morphology1.65473123
32MP0004272_abnormal_basement_membrane1.60849298
33MP0000537_abnormal_urethra_morphology1.60543085
34MP0000678_abnormal_parathyroid_gland1.59454421
35MP0005165_increased_susceptibility_to1.52092356
36MP0008260_abnormal_autophagy1.49511416
37MP0000490_abnormal_crypts_of1.49180014
38MP0009840_abnormal_foam_cell1.49157515
39MP0000383_abnormal_hair_follicle1.48148400
40MP0004957_abnormal_blastocyst_morpholog1.46401897
41MP0004019_abnormal_vitamin_homeostasis1.45920586
42MP0001849_ear_inflammation1.45384900
43MP0005257_abnormal_intraocular_pressure1.43729999
44MP0003693_abnormal_embryo_hatching1.41620814
45MP0003315_abnormal_perineum_morphology1.34936606
46MP0003941_abnormal_skin_development1.33264787
47MP0003123_paternal_imprinting1.29755212
48MP0000566_synostosis1.29492894
49MP0000377_abnormal_hair_follicle1.20530267
50MP0004185_abnormal_adipocyte_glucose1.19903677
51MP0004947_skin_inflammation1.19564137
52MP0004782_abnormal_surfactant_physiolog1.16093324
53MP0003186_abnormal_redox_activity1.14683717
54MP0003718_maternal_effect1.12983720
55MP0005409_darkened_coat_color1.10319709
56MP0000750_abnormal_muscle_regeneration1.10048751
57MP0001666_abnormal_nutrient_absorption1.05561958
58MP0005058_abnormal_lysosome_morphology1.05002635
59MP0010155_abnormal_intestine_physiology1.03968788
60MP0005085_abnormal_gallbladder_physiolo1.01344188
61MP0009643_abnormal_urine_homeostasis1.01007558
62MP0000627_abnormal_mammary_gland0.97860372
63MP0000358_abnormal_cell_content/0.97676599
64MP0009931_abnormal_skin_appearance0.97498727
65MP0003786_premature_aging0.95698479
66MP0008932_abnormal_embryonic_tissue0.93560767
67MP0003638_abnormal_response/metabolism_0.92264266
68MP0001765_abnormal_ion_homeostasis0.91571406
69MP0005275_abnormal_skin_tensile0.89524735
70MP0000477_abnormal_intestine_morphology0.88236025
71MP0005666_abnormal_adipose_tissue0.87959235
72MP0005670_abnormal_white_adipose0.84993105
73MP0002139_abnormal_hepatobiliary_system0.83343025
74MP0001873_stomach_inflammation0.82082239
75MP0000003_abnormal_adipose_tissue0.80598137
76MP0005365_abnormal_bile_salt0.80303509
77MP0001664_abnormal_digestion0.80029658
78MP0000013_abnormal_adipose_tissue0.79602539
79MP0003866_abnormal_defecation0.79150074
80MP0002332_abnormal_exercise_endurance0.78829292
81MP0003075_altered_response_to0.76444258
82MP0001661_extended_life_span0.76174363
83MP0000647_abnormal_sebaceous_gland0.75280818
84MP0001881_abnormal_mammary_gland0.75066094
85MP0009697_abnormal_copulation0.73970259
86MP0005584_abnormal_enzyme/coenzyme_acti0.73463540
87MP0000465_gastrointestinal_hemorrhage0.73335698
88MP0000343_altered_response_to0.73091782
89MP0001243_abnormal_dermal_layer0.71730137
90MP0005330_cardiomyopathy0.70400703
91MP0005375_adipose_tissue_phenotype0.70074937
92MP0002136_abnormal_kidney_physiology0.69262234
93MP0006036_abnormal_mitochondrial_physio0.69224651
94MP0003077_abnormal_cell_cycle0.67410377
95MP0005166_decreased_susceptibility_to0.66945358
96MP0009333_abnormal_splenocyte_physiolog0.66873315
97MP0002132_abnormal_respiratory_system0.66357788
98MP0001853_heart_inflammation0.66061955
99MP0001730_embryonic_growth_arrest0.64900265
100MP0001191_abnormal_skin_condition0.63360621

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)4.11543515
2Right ventricular cardiomyopathy (HP:0011663)4.00958861
3Alopecia of scalp (HP:0002293)3.97311099
4Plantar hyperkeratosis (HP:0007556)3.69896994
5Distal lower limb muscle weakness (HP:0009053)3.67874530
6Fragile nails (HP:0001808)3.64826561
7Milia (HP:0001056)3.63825946
8Nail dystrophy (HP:0008404)3.56206927
9Pili torti (HP:0003777)3.37834384
10Abnormality of the distal phalanges of the toes (HP:0010182)3.34818394
11Sparse eyelashes (HP:0000653)3.31034823
12Short nail (HP:0001799)3.27060755
13Reduced subcutaneous adipose tissue (HP:0003758)3.26760584
14Distal lower limb amyotrophy (HP:0008944)3.23169664
15Abnormal hair laboratory examination (HP:0003328)3.22525385
16Abnormality of nail color (HP:0100643)3.14561675
17Thick nail (HP:0001805)3.13882491
18Trismus (HP:0000211)3.09183389
19Palmoplantar hyperkeratosis (HP:0000972)3.07110707
20Hyperactive renin-angiotensin system (HP:0000841)3.05079680
21Vascular calcification (HP:0004934)2.93242564
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.91319837
23Osteolytic defects of the hand bones (HP:0009699)2.91319837
24Atrophic scars (HP:0001075)2.89064697
25Glucose intolerance (HP:0000833)2.82274914
26Rough bone trabeculation (HP:0100670)2.79218330
27Palmar hyperkeratosis (HP:0010765)2.78162040
28Congenital ichthyosiform erythroderma (HP:0007431)2.74134731
29Oral leukoplakia (HP:0002745)2.69971566
30Ridged nail (HP:0001807)2.64761605
31Acanthosis nigricans (HP:0000956)2.64341749
32Chronic bronchitis (HP:0004469)2.60125029
33Abnormal blistering of the skin (HP:0008066)2.56948644
34Erythema (HP:0010783)2.56743381
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.45728775
36Cardiovascular calcification (HP:0011915)2.45697924
37Abnormality of placental membranes (HP:0011409)2.44052893
38Amniotic constriction ring (HP:0009775)2.44052893
39Selective tooth agenesis (HP:0001592)2.42887220
40Petechiae (HP:0000967)2.41764990
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.37401131
42Axonal loss (HP:0003447)2.35260905
43Spinal cord compression (HP:0002176)2.33738228
44Male infertility (HP:0003251)2.31712905
45Upper limb amyotrophy (HP:0009129)2.31503453
46Distal upper limb amyotrophy (HP:0007149)2.31503453
47Abnormal trabecular bone morphology (HP:0100671)2.30779624
48Abnormality of the Achilles tendon (HP:0005109)2.30715622
49Achilles tendon contracture (HP:0001771)2.29521940
50Glomerulosclerosis (HP:0000096)2.27493823
51Focal segmental glomerulosclerosis (HP:0000097)2.25566028
52Conjugated hyperbilirubinemia (HP:0002908)2.24882088
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.24482004
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.24482004
55Hypotrichosis (HP:0001006)2.24027088
56Nasal polyposis (HP:0100582)2.17338326
57Vertebral compression fractures (HP:0002953)2.15647423
58Pterygium (HP:0001059)2.14842130
59Menorrhagia (HP:0000132)2.12761425
60Popliteal pterygium (HP:0009756)2.12210511
61Abnormalities of placenta or umbilical cord (HP:0001194)2.12118790
62Lip pit (HP:0100267)2.08737572
63Upper limb muscle weakness (HP:0003484)2.06821929
64Flat acetabular roof (HP:0003180)2.06351097
65Abnormal glucose tolerance (HP:0001952)2.05973397
66Malnutrition (HP:0004395)2.04839082
67Growth hormone excess (HP:0000845)2.04674590
68Micronodular cirrhosis (HP:0001413)2.04037392
69Natal tooth (HP:0000695)2.02681164
70Hypokinesia (HP:0002375)2.01149842
71Abnormal mitochondria in muscle tissue (HP:0008316)2.00237019
72Ileus (HP:0002595)1.98255282
73Entropion (HP:0000621)1.97551955
74Down-sloping shoulders (HP:0200021)1.97252769
75Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95915100
76Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94207028
77Interstitial pulmonary disease (HP:0006530)1.93861361
78Broad face (HP:0000283)1.93757106
79Increased connective tissue (HP:0009025)1.92535241
80Insulin resistance (HP:0000855)1.90061448
81Woolly hair (HP:0002224)1.88051754
82Abnormality of the umbilical cord (HP:0010881)1.87526820
83Abnormal respiratory motile cilium physiology (HP:0012261)1.87205559
84Lower limb amyotrophy (HP:0007210)1.85420237
85Fragile skin (HP:0001030)1.84805263
86Abnormality of aromatic amino acid family metabolism (HP:0004338)1.80525192
87Abdominal distention (HP:0003270)1.80173912
88Rhinitis (HP:0012384)1.79316889
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78376300
90Abnormality of glycolysis (HP:0004366)1.78156279
91Hepatocellular necrosis (HP:0001404)1.78054535
92Hypoplasia of dental enamel (HP:0006297)1.76094884
93Ankyloglossia (HP:0010296)1.75477918
94Hepatic necrosis (HP:0002605)1.73847820
95Corneal erosion (HP:0200020)1.73027672
96Amyloidosis (HP:0011034)1.71538401
97Deviation of the thumb (HP:0009603)1.71466984
98Abnormality of small intestinal villus morphology (HP:0011472)1.70859163
99Villous atrophy (HP:0011473)1.70859163
100Progressive hearing impairment (HP:0001730)1.70207266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.51325502
2EPHA26.42213496
3NME24.05029325
4MET3.33663716
5TESK13.01318365
6MST42.72952666
7ARAF2.59945196
8LMTK22.59660672
9IRAK32.58257480
10TESK22.27520787
11MAP3K122.25766383
12VRK22.13483552
13PAK42.06996904
14PIM21.91526686
15BUB11.82144091
16EPHB21.80654307
17LIMK11.76422043
18PBK1.66732757
19ERN11.65044797
20ILK1.62242484
21TRIB31.49941519
22PTK21.48282153
23MAPKAPK31.45692809
24ABL21.44388065
25BMX1.41763319
26EIF2AK11.40263599
27NME11.37785745
28MYLK1.27576655
29MAP3K31.22506797
30SIK11.18600405
31PRKCI1.12663531
32RPS6KB21.08910224
33SMG11.01823159
34SCYL21.00280909
35BRAF0.98339929
36STK100.96010722
37LRRK20.95531279
38EPHB10.90510394
39NEK10.88449021
40STK160.86958159
41MAP3K20.86831402
42DAPK10.86026334
43STK240.84570746
44TAOK20.79929361
45PTK60.79761741
46CDK80.78539760
47RIPK10.78047258
48ERBB40.72122886
49PRKG20.72028809
50MUSK0.67611911
51PAK10.65963744
52CAMK2G0.62849431
53FLT30.59390796
54AURKA0.59248175
55SIK30.57305205
56LATS20.54163939
57MAP3K80.51392168
58AURKB0.51259411
59NTRK10.51072928
60FER0.48534636
61PDK20.45941328
62PTK2B0.45260941
63BRSK10.44995101
64GRK50.44943402
65DAPK30.43605069
66RPS6KA40.41373309
67MAP3K110.41122205
68MAPK150.40811472
69PHKG10.38551926
70PHKG20.38551926
71MAP2K20.37881515
72MAP2K70.35415963
73IRAK20.34696356
74MOS0.33514186
75PRPF4B0.32824658
76MAPKAPK20.32518021
77MAP3K90.32453101
78TBK10.31687236
79ZAP700.31001918
80TLK10.30881475
81BCKDK0.28607870
82MAP2K10.28111166
83PDPK10.27385662
84SRPK10.27040853
85MAP3K10.27000361
86ICK0.26984083
87CAMK2D0.26008409
88CDK70.25165028
89PKN20.23585010
90RAF10.22080878
91TTN0.21928009
92PDGFRA0.21618751
93TTK0.20880669
94KDR0.20379219
95AKT20.19769734
96ROCK20.19345293
97CAMK2B0.18013264
98PRKCD0.17436669
99CDK90.17116629
100PLK10.16024957

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.55496141
2Sulfur metabolism_Homo sapiens_hsa009203.06335716
3Sulfur relay system_Homo sapiens_hsa041222.82043647
4Glutathione metabolism_Homo sapiens_hsa004802.69801577
5Fructose and mannose metabolism_Homo sapiens_hsa000512.68510287
6Galactose metabolism_Homo sapiens_hsa000522.67315454
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.59267858
8Ribosome_Homo sapiens_hsa030102.38538917
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.25770230
10Pentose phosphate pathway_Homo sapiens_hsa000302.24426912
11Phenylalanine metabolism_Homo sapiens_hsa003601.98964997
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.97461025
13Folate biosynthesis_Homo sapiens_hsa007901.95011837
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.94016139
15Pyrimidine metabolism_Homo sapiens_hsa002401.91385909
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.90289318
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83115581
18Fatty acid elongation_Homo sapiens_hsa000621.77177306
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.75702501
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.69561185
21Biosynthesis of amino acids_Homo sapiens_hsa012301.65964819
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61559357
23Oxidative phosphorylation_Homo sapiens_hsa001901.60126874
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52022741
25Huntingtons disease_Homo sapiens_hsa050161.51426443
26DNA replication_Homo sapiens_hsa030301.51185836
27Chemical carcinogenesis_Homo sapiens_hsa052041.47928005
28Arginine biosynthesis_Homo sapiens_hsa002201.37876331
29Base excision repair_Homo sapiens_hsa034101.35663019
30N-Glycan biosynthesis_Homo sapiens_hsa005101.35199048
31Tyrosine metabolism_Homo sapiens_hsa003501.32521544
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32288740
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29637204
34Mismatch repair_Homo sapiens_hsa034301.27278840
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25628211
36Parkinsons disease_Homo sapiens_hsa050121.24875971
37Alzheimers disease_Homo sapiens_hsa050101.20365944
38Carbon metabolism_Homo sapiens_hsa012001.16293263
39Arachidonic acid metabolism_Homo sapiens_hsa005901.15871630
40Vibrio cholerae infection_Homo sapiens_hsa051101.14950725
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13774893
42Starch and sucrose metabolism_Homo sapiens_hsa005001.12325520
43Shigellosis_Homo sapiens_hsa051311.08074012
44Fat digestion and absorption_Homo sapiens_hsa049751.07981970
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06249288
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05125991
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03058014
48Histidine metabolism_Homo sapiens_hsa003401.00596532
49Nucleotide excision repair_Homo sapiens_hsa034201.00203397
50Pyruvate metabolism_Homo sapiens_hsa006200.98978256
51Mineral absorption_Homo sapiens_hsa049780.96153577
52Arginine and proline metabolism_Homo sapiens_hsa003300.90127452
53Sphingolipid metabolism_Homo sapiens_hsa006000.90058356
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88550517
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.87452839
56Thyroid cancer_Homo sapiens_hsa052160.85050730
57Endocytosis_Homo sapiens_hsa041440.83275588
58RNA polymerase_Homo sapiens_hsa030200.82505771
59Tight junction_Homo sapiens_hsa045300.81489325
60Vitamin digestion and absorption_Homo sapiens_hsa049770.79931579
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.77723032
62Small cell lung cancer_Homo sapiens_hsa052220.74210460
63Bladder cancer_Homo sapiens_hsa052190.74112913
64Adherens junction_Homo sapiens_hsa045200.72518560
65Metabolic pathways_Homo sapiens_hsa011000.72156014
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71679758
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69571846
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69474799
69Purine metabolism_Homo sapiens_hsa002300.68357586
70Retinol metabolism_Homo sapiens_hsa008300.67140133
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64935444
72Apoptosis_Homo sapiens_hsa042100.64869396
73Salmonella infection_Homo sapiens_hsa051320.62524220
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.60946992
75Renin-angiotensin system_Homo sapiens_hsa046140.60778708
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59125024
77ECM-receptor interaction_Homo sapiens_hsa045120.57685142
78Pancreatic cancer_Homo sapiens_hsa052120.53739881
79Leukocyte transendothelial migration_Homo sapiens_hsa046700.50066990
80beta-Alanine metabolism_Homo sapiens_hsa004100.49341700
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48647649
82p53 signaling pathway_Homo sapiens_hsa041150.46959626
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46046519
84Other glycan degradation_Homo sapiens_hsa005110.45881602
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45026207
86Focal adhesion_Homo sapiens_hsa045100.44978765
87Hepatitis C_Homo sapiens_hsa051600.43705601
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43214068
89Proteoglycans in cancer_Homo sapiens_hsa052050.41192064
90Chronic myeloid leukemia_Homo sapiens_hsa052200.38405072
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38326440
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35476021
93Vitamin B6 metabolism_Homo sapiens_hsa007500.32142594
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.31636946
95Bile secretion_Homo sapiens_hsa049760.29568658
96Glycerolipid metabolism_Homo sapiens_hsa005610.27617259
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.24713782
98PPAR signaling pathway_Homo sapiens_hsa033200.24329624
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.24182026
100Caffeine metabolism_Homo sapiens_hsa002320.19368696

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