C19ORF35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.03751517
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44065141
3negative regulation of cell killing (GO:0031342)4.44065141
4cytidine deamination (GO:0009972)4.09960417
5cytidine metabolic process (GO:0046087)4.09960417
6cytidine catabolic process (GO:0006216)4.09960417
7positive regulation by symbiont of host defense response (GO:0052509)4.00118444
8modulation by symbiont of host defense response (GO:0052031)4.00118444
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.00118444
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.00118444
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.00118444
12modulation by symbiont of host immune response (GO:0052553)4.00118444
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96932843
14behavioral response to nicotine (GO:0035095)3.94545425
15negative regulation of mast cell activation (GO:0033004)3.89085564
16pyrimidine ribonucleoside catabolic process (GO:0046133)3.75911032
17regulation of interferon-beta biosynthetic process (GO:0045357)3.72299208
18neutrophil activation involved in immune response (GO:0002283)3.64751789
19regulation of mast cell activation (GO:0033003)3.59974028
20positive regulation of mast cell activation (GO:0033005)3.59770156
21leukocyte migration involved in inflammatory response (GO:0002523)3.55304803
22regulation of B cell receptor signaling pathway (GO:0050855)3.51207227
23cellular response to interleukin-15 (GO:0071350)3.50287678
24activated T cell proliferation (GO:0050798)3.41372751
25L-fucose catabolic process (GO:0042355)3.40989506
26fucose catabolic process (GO:0019317)3.40989506
27L-fucose metabolic process (GO:0042354)3.40989506
28cellular response to ATP (GO:0071318)3.37144455
29macrophage activation involved in immune response (GO:0002281)3.35447156
30neutrophil activation (GO:0042119)3.35149457
31microglial cell activation (GO:0001774)3.30359571
32positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29745147
33cellular extravasation (GO:0045123)3.28714866
34neutrophil mediated immunity (GO:0002446)3.17199321
35positive regulation of gamma-delta T cell activation (GO:0046645)3.13303098
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.12792043
37regulation of memory T cell differentiation (GO:0043380)3.11186394
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.10990231
39response to interleukin-15 (GO:0070672)3.10511889
40positive regulation of mast cell degranulation (GO:0043306)3.09883633
41positive regulation of mast cell activation involved in immune response (GO:0033008)3.09883633
42negative regulation of interleukin-1 production (GO:0032692)3.09666670
43negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09146589
44negative regulation of interleukin-12 production (GO:0032695)3.05578086
45detection of light stimulus involved in visual perception (GO:0050908)3.04331007
46detection of light stimulus involved in sensory perception (GO:0050962)3.04331007
47antigen processing and presentation of endogenous antigen (GO:0019883)2.99851393
48negative regulation of T cell mediated immunity (GO:0002710)2.99232682
49regulation of mast cell degranulation (GO:0043304)2.98967149
50granulocyte activation (GO:0036230)2.97948752
51regulation of mast cell activation involved in immune response (GO:0033006)2.94902609
52indole-containing compound catabolic process (GO:0042436)2.94206500
53indolalkylamine catabolic process (GO:0046218)2.94206500
54tryptophan catabolic process (GO:0006569)2.94206500
55respiratory burst (GO:0045730)2.92735616
56superoxide anion generation (GO:0042554)2.90026672
57leukocyte aggregation (GO:0070486)2.88544835
58detection of other organism (GO:0098543)2.84164188
59leukocyte degranulation (GO:0043299)2.82417920
60regulation of T cell mediated cytotoxicity (GO:0001914)2.82088274
61interferon-gamma production (GO:0032609)2.81507899
62myeloid cell activation involved in immune response (GO:0002275)2.80881882
63positive regulation of T cell mediated cytotoxicity (GO:0001916)2.80350604
64negative regulation of phagocytosis (GO:0050765)2.79083003
65positive regulation of defense response to virus by host (GO:0002230)2.78744672
66negative regulation of alpha-beta T cell activation (GO:0046636)2.76655009
67sulfation (GO:0051923)2.75604467
68detection of bacterium (GO:0016045)2.75356493
69adaptation of signaling pathway (GO:0023058)2.74927497
70negative regulation of interleukin-1 beta production (GO:0032691)2.74772799
71regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73466729
72myeloid leukocyte mediated immunity (GO:0002444)2.72977419
73regulation of regulatory T cell differentiation (GO:0045589)2.72123171
74response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.72063427
75response to host immune response (GO:0052572)2.72063427
76kynurenine metabolic process (GO:0070189)2.69608005
77negative regulation of interleukin-6 production (GO:0032715)2.67256272
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66903960
79tolerance induction (GO:0002507)2.65653898
80indolalkylamine metabolic process (GO:0006586)2.65120453
81negative regulation of leukocyte mediated immunity (GO:0002704)2.62828945
82production of molecular mediator involved in inflammatory response (GO:0002532)2.62112890
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.61933133
84negative regulation of T-helper cell differentiation (GO:0045623)2.59590689
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.59590689
86positive regulation of interleukin-1 beta secretion (GO:0050718)2.57318200
87hydrogen peroxide biosynthetic process (GO:0050665)2.56993677
88positive regulation of interferon-alpha production (GO:0032727)2.55033337
89mast cell activation (GO:0045576)2.54566370
90phosphatidylinositol acyl-chain remodeling (GO:0036149)2.54003962
91regulation of T cell tolerance induction (GO:0002664)2.53716705
92tryptophan metabolic process (GO:0006568)2.53071135
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53056733
94positive regulation of T-helper 1 type immune response (GO:0002827)2.52010598
95positive regulation of T cell differentiation in thymus (GO:0033089)2.51273472
96regulation of gamma-delta T cell activation (GO:0046643)2.50670912
97macrophage activation (GO:0042116)2.50485268
98regulation of interleukin-6 biosynthetic process (GO:0045408)2.49282588
99immunoglobulin mediated immune response (GO:0016064)2.49043468
100regulation of interferon-alpha production (GO:0032647)2.47052591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.34513211
2IRF8_21731497_ChIP-ChIP_J774_Mouse2.96913440
3ZNF274_21170338_ChIP-Seq_K562_Hela2.92695470
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71554581
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.53135584
6EZH2_22144423_ChIP-Seq_EOC_Human2.10759172
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01841212
8BP1_19119308_ChIP-ChIP_Hs578T_Human1.93630598
9LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88397524
10NOTCH1_21737748_ChIP-Seq_TLL_Human1.86295207
11GBX2_23144817_ChIP-Seq_PC3_Human1.82041657
12EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.77330386
13RUNX_20019798_ChIP-Seq_JUKART_Human1.72561134
14IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71283255
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70728829
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69922200
17RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68277821
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.60956290
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60682598
20GATA3_26560356_Chip-Seq_TH2_Human1.60392060
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.60112378
22VDR_22108803_ChIP-Seq_LS180_Human1.58126335
23ER_23166858_ChIP-Seq_MCF-7_Human1.53910925
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51787370
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51749875
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.51498841
27TP53_22573176_ChIP-Seq_HFKS_Human1.49893194
28GATA3_21878914_ChIP-Seq_MCF-7_Human1.46854645
29* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.43897520
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42921437
31NANOG_20526341_ChIP-Seq_ESCs_Human1.41080322
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40099933
33ERA_21632823_ChIP-Seq_H3396_Human1.40049444
34BCL6_27268052_Chip-Seq_Bcells_Human1.39286617
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36039939
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35769453
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35050654
38* TAF2_19829295_ChIP-Seq_ESCs_Human1.34803788
39NCOR_22424771_ChIP-Seq_293T_Human1.33122747
40BCAT_22108803_ChIP-Seq_LS180_Human1.32643533
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27527579
42GATA3_27048872_Chip-Seq_THYMUS_Human1.26423510
43DROSHA_22980978_ChIP-Seq_HELA_Human1.26206086
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25341136
45GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.24746288
46RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.24330836
47* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23925323
48* SPI1_23547873_ChIP-Seq_NB4_Human1.23908586
49IRF1_19129219_ChIP-ChIP_H3396_Human1.23074818
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21767330
51* SMRT_27268052_Chip-Seq_Bcells_Human1.20215269
52IGF1R_20145208_ChIP-Seq_DFB_Human1.19953585
53REST_21632747_ChIP-Seq_MESCs_Mouse1.19921330
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19440987
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16719499
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16475075
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15187955
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14069720
59FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11024239
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.10628228
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10297071
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.09247794
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09247794
64MYB_26560356_Chip-Seq_TH2_Human1.09144881
65VDR_24763502_ChIP-Seq_THP-1_Human1.09045862
66RAC3_21632823_ChIP-Seq_H3396_Human1.08026804
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07857399
68* E2F1_20622854_ChIP-Seq_HELA_Human1.06147176
69* OCT4_20526341_ChIP-Seq_ESCs_Human1.05750867
70MYC_19829295_ChIP-Seq_ESCs_Human1.05382939
71PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04927499
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04320549
73VDR_24787735_ChIP-Seq_THP-1_Human1.02400849
74* P300_27268052_Chip-Seq_Bcells_Human1.02135329
75EWS_26573619_Chip-Seq_HEK293_Human1.01400559
76P53_21459846_ChIP-Seq_SAOS-2_Human1.00574075
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99660969
78YY1_22570637_ChIP-Seq_MALME-3M_Human0.98793767
79* BCOR_27268052_Chip-Seq_Bcells_Human0.98385185
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98162731
81* TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98119754
82SPI1_23127762_ChIP-Seq_K562_Human0.97722409
83SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96427738
84PRDM14_20953172_ChIP-Seq_ESCs_Human0.95839602
85BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.95530240
86* FOXH1_21741376_ChIP-Seq_ESCs_Human0.95453780
87* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95239018
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.93737832
89SCL_19346495_ChIP-Seq_HPC-7_Human0.93555645
90AR_20517297_ChIP-Seq_VCAP_Human0.93102328
91CTCF_20526341_ChIP-Seq_ESCs_Human0.92169767
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92154270
93HOXB7_26014856_ChIP-Seq_BT474_Human0.91651716
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91620665
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90848299
96P300_19829295_ChIP-Seq_ESCs_Human0.90632880
97* VDR_21846776_ChIP-Seq_THP-1_Human0.89774516
98BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88963660
99NANOG_19829295_ChIP-Seq_ESCs_Human0.88056385
100SOX2_19829295_ChIP-Seq_ESCs_Human0.88056385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.11664487
2MP0002653_abnormal_ependyma_morphology3.10326035
3MP0005671_abnormal_response_to2.61512334
4MP0002277_abnormal_respiratory_mucosa2.59310469
5MP0001986_abnormal_taste_sensitivity2.43008574
6MP0001835_abnormal_antigen_presentation2.37449374
7MP0003436_decreased_susceptibility_to2.31958871
8MP0003011_delayed_dark_adaptation2.30567521
9MP0001800_abnormal_humoral_immune2.19842067
10MP0000685_abnormal_immune_system2.16716561
11MP0009785_altered_susceptibility_to2.15922408
12MP0005174_abnormal_tail_pigmentation2.10198004
13MP0002419_abnormal_innate_immunity2.08351702
14MP0001790_abnormal_immune_system2.08028945
15MP0005387_immune_system_phenotype2.08028945
16MP0001968_abnormal_touch/_nociception2.03285039
17MP0003195_calcinosis1.99929207
18MP0002148_abnormal_hypersensitivity_rea1.99142529
19MP0005025_abnormal_response_to1.96278854
20MP0000569_abnormal_digit_pigmentation1.90400402
21MP0002723_abnormal_immune_serum1.90336789
22MP0005000_abnormal_immune_tolerance1.79991508
23MP0002420_abnormal_adaptive_immunity1.79626060
24MP0001819_abnormal_immune_cell1.78624521
25MP0002452_abnormal_antigen_presenting1.77219572
26MP0003646_muscle_fatigue1.76282213
27MP0002102_abnormal_ear_morphology1.74491146
28MP0006292_abnormal_olfactory_placode1.73982620
29MP0005551_abnormal_eye_electrophysiolog1.72161120
30MP0004381_abnormal_hair_follicle1.68035999
31MP0006082_CNS_inflammation1.66290966
32MP0009764_decreased_sensitivity_to1.59239720
33MP0002736_abnormal_nociception_after1.55570100
34MP0003183_abnormal_peptide_metabolism1.49911803
35MP0002132_abnormal_respiratory_system1.48790287
36MP0003136_yellow_coat_color1.47967349
37MP0004130_abnormal_muscle_cell1.46463036
38MP0008872_abnormal_physiological_respon1.43617957
39MP0002876_abnormal_thyroid_physiology1.37558305
40MP0008877_abnormal_DNA_methylation1.35850906
41MP0004142_abnormal_muscle_tone1.34120542
42MP0001873_stomach_inflammation1.29184205
43MP0003878_abnormal_ear_physiology1.28633464
44MP0005377_hearing/vestibular/ear_phenot1.28633464
45MP0002837_dystrophic_cardiac_calcinosis1.28546503
46MP0002928_abnormal_bile_duct1.28458200
47MP0003303_peritoneal_inflammation1.26975206
48MP0002405_respiratory_system_inflammati1.26673885
49MP0005083_abnormal_biliary_tract1.25633370
50MP0000015_abnormal_ear_pigmentation1.24470425
51MP0000716_abnormal_immune_system1.23304426
52MP0005084_abnormal_gallbladder_morpholo1.22587833
53MP0001533_abnormal_skeleton_physiology1.21666259
54MP0005310_abnormal_salivary_gland1.21225181
55MP0005075_abnormal_melanosome_morpholog1.20245420
56MP0002138_abnormal_hepatobiliary_system1.20126855
57MP0001485_abnormal_pinna_reflex1.18857974
58MP0001845_abnormal_inflammatory_respons1.17278947
59MP0005646_abnormal_pituitary_gland1.16218931
60MP0002254_reproductive_system_inflammat1.15025465
61MP0009745_abnormal_behavioral_response1.06503602
62MP0002398_abnormal_bone_marrow1.05890074
63MP0000689_abnormal_spleen_morphology1.05473085
64MP0008875_abnormal_xenobiotic_pharmacok1.04844748
65MP0003787_abnormal_imprinting1.04152031
66MP0003172_abnormal_lysosome_physiology1.01199904
67MP0002638_abnormal_pupillary_reflex0.96258260
68MP0008469_abnormal_protein_level0.95237796
69MP0005253_abnormal_eye_physiology0.94969903
70MP0002735_abnormal_chemical_nociception0.94536804
71MP0001970_abnormal_pain_threshold0.94154414
72MP0001501_abnormal_sleep_pattern0.91683515
73MP0000631_abnormal_neuroendocrine_gland0.91298954
74MP0002733_abnormal_thermal_nociception0.91213683
75MP0000372_irregular_coat_pigmentation0.90972822
76MP0002693_abnormal_pancreas_physiology0.90411478
77MP0001663_abnormal_digestive_system0.88161237
78MP0002429_abnormal_blood_cell0.87783502
79MP0002163_abnormal_gland_morphology0.84354059
80MP0000470_abnormal_stomach_morphology0.83236665
81MP0002722_abnormal_immune_system0.83218401
82MP0002272_abnormal_nervous_system0.82439462
83MP0000427_abnormal_hair_cycle0.81179606
84MP0001486_abnormal_startle_reflex0.81062840
85MP0009278_abnormal_bone_marrow0.81010755
86MP0004145_abnormal_muscle_electrophysio0.80040981
87MP0001502_abnormal_circadian_rhythm0.80025986
88MP0009765_abnormal_xenobiotic_induced0.79975150
89MP0003866_abnormal_defecation0.78861936
90MP0005645_abnormal_hypothalamus_physiol0.78669791
91MP0005389_reproductive_system_phenotype0.78353840
92MP0009046_muscle_twitch0.77704319
93MP0005448_abnormal_energy_balance0.77105881
94MP0004885_abnormal_endolymph0.77086887
95MP0002064_seizures0.77085321
96MP0004742_abnormal_vestibular_system0.76750942
97MP0005464_abnormal_platelet_physiology0.76506802
98MP0002095_abnormal_skin_pigmentation0.75529922
99MP0001765_abnormal_ion_homeostasis0.75156310
100MP0001919_abnormal_reproductive_system0.74344429

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.64215051
2Elevated erythrocyte sedimentation rate (HP:0003565)4.28830824
3Congenital stationary night blindness (HP:0007642)4.04910350
4Myositis (HP:0100614)3.65645317
5Optic neuritis (HP:0100653)3.62735362
6Retrobulbar optic neuritis (HP:0100654)3.62735362
7Hypochromic microcytic anemia (HP:0004840)3.56421046
8Orchitis (HP:0100796)3.53102346
9Pancreatic cysts (HP:0001737)3.35705950
10Pancreatic fibrosis (HP:0100732)3.32473523
11Molar tooth sign on MRI (HP:0002419)3.18093058
12Abnormality of midbrain morphology (HP:0002418)3.18093058
13Hypochromic anemia (HP:0001931)3.08929847
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.04218009
15Attenuation of retinal blood vessels (HP:0007843)3.00735866
16Recurrent bacterial skin infections (HP:0005406)3.00585947
17Recurrent abscess formation (HP:0002722)2.99568449
18True hermaphroditism (HP:0010459)2.99526142
19Eczematoid dermatitis (HP:0000976)2.92191056
20Recurrent fungal infections (HP:0002841)2.90820251
21Pendular nystagmus (HP:0012043)2.88273654
22Abnormal rod and cone electroretinograms (HP:0008323)2.84702723
23Abolished electroretinogram (ERG) (HP:0000550)2.82564186
24Decreased central vision (HP:0007663)2.81488730
25Keratoconjunctivitis (HP:0001096)2.79687646
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70296262
27Progressive cerebellar ataxia (HP:0002073)2.67946731
28Abnormality of macrophages (HP:0004311)2.67945404
29Encephalitis (HP:0002383)2.66120127
30Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64992079
31Nephronophthisis (HP:0000090)2.64372122
32Absent/shortened dynein arms (HP:0200106)2.57842297
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.57842297
34Keratoconjunctivitis sicca (HP:0001097)2.56241580
35Recurrent cutaneous fungal infections (HP:0011370)2.54368472
36Chronic mucocutaneous candidiasis (HP:0002728)2.54368472
37Polydipsia (HP:0001959)2.48236988
38Abnormal drinking behavior (HP:0030082)2.48236988
39Severe visual impairment (HP:0001141)2.46596837
40Bony spicule pigmentary retinopathy (HP:0007737)2.39958804
41Recurrent gram-negative bacterial infections (HP:0005420)2.37915986
42Genetic anticipation (HP:0003743)2.33078118
43Gastrointestinal infarctions (HP:0005244)2.29920300
44Recurrent skin infections (HP:0001581)2.29063471
45Asplenia (HP:0001746)2.28858736
46Panhypogammaglobulinemia (HP:0003139)2.28313291
47Aplasia/Hypoplasia of the spleen (HP:0010451)2.27143334
48Abnormality of the renal cortex (HP:0011035)2.26076106
49Meningitis (HP:0001287)2.23353667
50Anorexia (HP:0002039)2.20048900
51Mediastinal lymphadenopathy (HP:0100721)2.19698477
52Episodic fever (HP:0001954)2.17621041
53Abnormality of the renal medulla (HP:0100957)2.17555390
54Vasculitis (HP:0002633)2.13001190
55Absent thumb (HP:0009777)2.11544471
56Leukocytosis (HP:0001974)2.11011135
57Stomach cancer (HP:0012126)2.10320753
58Chronic hepatic failure (HP:0100626)2.09813087
593-Methylglutaconic aciduria (HP:0003535)2.09311635
60IgG deficiency (HP:0004315)2.07800607
61Increased corneal curvature (HP:0100692)2.05637342
62Keratoconus (HP:0000563)2.05637342
63Abnormal respiratory epithelium morphology (HP:0012253)2.03757466
64Abnormal respiratory motile cilium morphology (HP:0005938)2.03757466
65Obstructive lung disease (HP:0006536)2.00511775
66Chronic obstructive pulmonary disease (HP:0006510)2.00511775
67Constricted visual fields (HP:0001133)2.00492605
68Agitation (HP:0000713)1.99019382
69Methylmalonic acidemia (HP:0002912)1.98098427
70Abnormality of eosinophils (HP:0001879)1.97659427
71Hemoptysis (HP:0002105)1.95687700
72Polyuria (HP:0000103)1.94480126
73Cystic liver disease (HP:0006706)1.93520581
74Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92277229
75Short 1st metacarpal (HP:0010034)1.92277229
76Pustule (HP:0200039)1.90717980
77Congenital sensorineural hearing impairment (HP:0008527)1.88779260
78Abnormality of T cell physiology (HP:0011840)1.85727463
79Rib fusion (HP:0000902)1.84080951
80Severe combined immunodeficiency (HP:0004430)1.82330030
81Pulmonary infiltrates (HP:0002113)1.81205909
82Abnormality of T cells (HP:0002843)1.80633737
83Thyroiditis (HP:0100646)1.78664837
84Tetany (HP:0001281)1.78311066
85Cheilitis (HP:0100825)1.76279580
86Abnormality of the renal collecting system (HP:0004742)1.76133874
87Keratitis (HP:0000491)1.73802504
88Abnormal ciliary motility (HP:0012262)1.73354687
89Increased IgE level (HP:0003212)1.70339618
90Visual hallucinations (HP:0002367)1.70335183
91Macular degeneration (HP:0000608)1.70181219
92Microcytic anemia (HP:0001935)1.68717819
93Concave nail (HP:0001598)1.66332836
94Type II lissencephaly (HP:0007260)1.65573444
95Methylmalonic aciduria (HP:0012120)1.65124864
96Chest pain (HP:0100749)1.64924787
97Eosinophilia (HP:0001880)1.64337782
98Abnormality of the 1st metacarpal (HP:0010009)1.64262922
99Tubular atrophy (HP:0000092)1.63806108
100Furrowed tongue (HP:0000221)1.63330354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.50318341
2TXK2.90306627
3MAP4K12.82959179
4ADRBK22.82903062
5IRAK42.68859150
6TNK22.51376897
7RIPK42.50796423
8GRK12.33369712
9TAOK32.33179547
10TLK12.30886423
11WNK42.03147428
12BLK2.02833686
13GRK61.96542449
14BMPR1B1.72926333
15ACVR1B1.70884061
16PINK11.69657526
17INSRR1.67247062
18PRKD21.64440398
19DAPK21.63535285
20WNK31.59651234
21CSK1.59481012
22NUAK11.57747367
23CAMKK21.53818515
24OXSR11.50002425
25SYK1.46220181
26BTK1.44803816
27FES1.43572732
28ZAK1.34099623
29MAPK131.32906824
30TYK21.32327422
31MAP4K21.31713604
32HCK1.26921509
33IKBKB1.26829143
34MAP3K111.21242481
35MAP2K31.19816640
36IKBKE1.18023371
37LYN1.14851187
38MAP2K61.13112277
39MAPK151.12412238
40TAOK11.12297122
41SIK21.09290678
42PTK2B1.06217255
43DYRK21.04916731
44ADRBK11.04385299
45ZAP701.01035334
46KIT0.99979003
47PRKCQ0.95098842
48LCK0.91748927
49PAK30.90544306
50TEC0.88656818
51STK110.88468666
52IRAK10.84647862
53STK390.83698150
54ITK0.81522040
55CDK190.78383014
56ERN10.77323599
57JAK30.76844777
58EPHB10.75840030
59STK160.74514797
60GRK70.74046153
61CSF1R0.71758627
62HIPK20.65890439
63RPS6KA60.65013810
64DYRK30.64899227
65MARK30.64634254
66PRKCZ0.63841284
67EPHA30.62427330
68JAK20.60377789
69FGR0.58299859
70CAMKK10.57077263
71MAP2K20.56127588
72CASK0.55874197
73TAF10.55638139
74MAP2K40.51814698
75CAMK10.50214424
76TBK10.50055450
77MARK20.49875510
78CHUK0.47040058
79GRK50.47028201
80PRKCH0.46857141
81SGK20.46199790
82PIK3CG0.45353717
83MUSK0.45046339
84MAP3K30.42251680
85STK380.41282487
86PRKAA20.38646916
87PRKCG0.38591909
88PRKCE0.37314980
89JAK10.36238678
90CAMK40.35693603
91MATK0.35641062
92PRKD10.35463614
93RPS6KL10.35387502
94RPS6KC10.35387502
95ABL10.34942538
96PDK10.33727275
97PRKACA0.33440698
98PIM10.32793376
99PRKCI0.32600310
100RPS6KA50.32477258

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.82071023
2Primary immunodeficiency_Homo sapiens_hsa053402.80120765
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.53781962
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36762042
5Linoleic acid metabolism_Homo sapiens_hsa005912.25913592
6Phototransduction_Homo sapiens_hsa047442.17928213
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.17633069
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.15542616
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12026613
10Graft-versus-host disease_Homo sapiens_hsa053322.06468548
11Staphylococcus aureus infection_Homo sapiens_hsa051501.96349746
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95700207
13Ether lipid metabolism_Homo sapiens_hsa005651.87628061
14Allograft rejection_Homo sapiens_hsa053301.87462046
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82710742
16Autoimmune thyroid disease_Homo sapiens_hsa053201.79952235
17Osteoclast differentiation_Homo sapiens_hsa043801.78004861
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.77176826
19Type I diabetes mellitus_Homo sapiens_hsa049401.67554403
20Nitrogen metabolism_Homo sapiens_hsa009101.64990433
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.58863691
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53883875
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52736156
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52615578
25Leishmaniasis_Homo sapiens_hsa051401.51619196
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.46479217
27Hematopoietic cell lineage_Homo sapiens_hsa046401.45032919
28Asthma_Homo sapiens_hsa053101.44891687
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.43341130
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40041479
31Caffeine metabolism_Homo sapiens_hsa002321.35151461
32Arachidonic acid metabolism_Homo sapiens_hsa005901.22454109
33Tuberculosis_Homo sapiens_hsa051521.21221886
34Regulation of autophagy_Homo sapiens_hsa041401.19077102
35Oxidative phosphorylation_Homo sapiens_hsa001901.12104584
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.11866209
37Nicotine addiction_Homo sapiens_hsa050331.08794136
38Malaria_Homo sapiens_hsa051441.08116109
39Morphine addiction_Homo sapiens_hsa050321.06653633
40African trypanosomiasis_Homo sapiens_hsa051431.04427246
41Chemokine signaling pathway_Homo sapiens_hsa040621.04257370
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.03331665
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.03265251
44Antigen processing and presentation_Homo sapiens_hsa046121.00281777
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.96738212
46Olfactory transduction_Homo sapiens_hsa047400.96151829
47Homologous recombination_Homo sapiens_hsa034400.94844061
48Tryptophan metabolism_Homo sapiens_hsa003800.93322058
49Collecting duct acid secretion_Homo sapiens_hsa049660.92969107
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91299330
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.90248314
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87374044
53Rheumatoid arthritis_Homo sapiens_hsa053230.84047680
54B cell receptor signaling pathway_Homo sapiens_hsa046620.82806745
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82547466
56Measles_Homo sapiens_hsa051620.81453441
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81051411
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80363791
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79332387
60T cell receptor signaling pathway_Homo sapiens_hsa046600.79003049
61Taste transduction_Homo sapiens_hsa047420.77818032
62Chemical carcinogenesis_Homo sapiens_hsa052040.76203570
63Fanconi anemia pathway_Homo sapiens_hsa034600.73582398
64Basal transcription factors_Homo sapiens_hsa030220.72797047
65Vitamin digestion and absorption_Homo sapiens_hsa049770.72403162
66Glycerolipid metabolism_Homo sapiens_hsa005610.70011546
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68503747
68Sulfur relay system_Homo sapiens_hsa041220.66980134
69Ovarian steroidogenesis_Homo sapiens_hsa049130.65886164
70Protein export_Homo sapiens_hsa030600.62967830
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.61679181
72Herpes simplex infection_Homo sapiens_hsa051680.58317231
73Legionellosis_Homo sapiens_hsa051340.57999900
74Serotonergic synapse_Homo sapiens_hsa047260.57041644
75Phagosome_Homo sapiens_hsa041450.56223076
76Parkinsons disease_Homo sapiens_hsa050120.56174894
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55721179
78Sulfur metabolism_Homo sapiens_hsa009200.55216987
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54948151
80Dorso-ventral axis formation_Homo sapiens_hsa043200.49478448
81Retinol metabolism_Homo sapiens_hsa008300.47534951
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46472268
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42863228
84Lysosome_Homo sapiens_hsa041420.42544285
85RNA polymerase_Homo sapiens_hsa030200.41520019
86Selenocompound metabolism_Homo sapiens_hsa004500.41413512
87Type II diabetes mellitus_Homo sapiens_hsa049300.40845692
88TNF signaling pathway_Homo sapiens_hsa046680.38632971
89Histidine metabolism_Homo sapiens_hsa003400.38130524
90Glutamatergic synapse_Homo sapiens_hsa047240.37753635
91MAPK signaling pathway_Homo sapiens_hsa040100.37647624
92Insulin secretion_Homo sapiens_hsa049110.37186900
93Peroxisome_Homo sapiens_hsa041460.37054088
94Circadian entrainment_Homo sapiens_hsa047130.37007691
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36636734
96Calcium signaling pathway_Homo sapiens_hsa040200.36547251
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.35224756
98GABAergic synapse_Homo sapiens_hsa047270.34494411
99Toxoplasmosis_Homo sapiens_hsa051450.33192412
100cAMP signaling pathway_Homo sapiens_hsa040240.32822618

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