C19ORF38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.28737175
2negative regulation of cell killing (GO:0031342)5.64629240
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.64629240
4response to peptidoglycan (GO:0032494)5.61160463
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60690029
6positive regulation of gamma-delta T cell activation (GO:0046645)5.59726337
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.57654876
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.57654876
9modulation by symbiont of host immune response (GO:0052553)5.57654876
10positive regulation by symbiont of host defense response (GO:0052509)5.57654876
11modulation by symbiont of host defense response (GO:0052031)5.57654876
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.57654876
13detection of other organism (GO:0098543)5.43914055
14detection of bacterium (GO:0016045)5.25425506
15antigen processing and presentation of endogenous antigen (GO:0019883)5.15975858
16macrophage activation involved in immune response (GO:0002281)4.85564379
17leukocyte aggregation (GO:0070486)4.82926413
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.79372662
19immunoglobulin mediated immune response (GO:0016064)4.70788774
20negative regulation of interleukin-12 production (GO:0032695)4.52820575
21detection of external biotic stimulus (GO:0098581)4.49103702
22neutrophil activation (GO:0042119)4.45933992
23regulation of B cell receptor signaling pathway (GO:0050855)4.45615166
24cellular extravasation (GO:0045123)4.43557961
25leukocyte migration involved in inflammatory response (GO:0002523)4.37848978
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29945605
27regulation of mast cell degranulation (GO:0043304)4.26213301
28respiratory burst (GO:0045730)4.20785121
29granulocyte activation (GO:0036230)4.12836186
30detection of molecule of bacterial origin (GO:0032490)4.12827898
31positive regulation of mast cell activation (GO:0033005)4.11220655
32regulation of interferon-beta biosynthetic process (GO:0045357)4.07736619
33detection of biotic stimulus (GO:0009595)4.03844710
34response to host immune response (GO:0052572)4.00817097
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.00817097
36regulation of mast cell activation involved in immune response (GO:0033006)4.00397408
37microglial cell activation (GO:0001774)3.98657442
38myeloid cell activation involved in immune response (GO:0002275)3.94845751
39regulation of gamma-delta T cell activation (GO:0046643)3.93475478
40regulation of myeloid leukocyte mediated immunity (GO:0002886)3.91789943
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.91647541
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.87511246
43regulation of mast cell activation (GO:0033003)3.79715024
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.75360819
45positive regulation of mast cell degranulation (GO:0043306)3.75360819
46macrophage activation (GO:0042116)3.73536465
47regulation of leukocyte degranulation (GO:0043300)3.73311632
48B cell mediated immunity (GO:0019724)3.68274953
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67539223
50neutrophil mediated immunity (GO:0002446)3.66177678
51response to host (GO:0075136)3.65987746
52response to host defenses (GO:0052200)3.65987746
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65987746
54response to muramyl dipeptide (GO:0032495)3.56071399
55negative regulation of leukocyte mediated immunity (GO:0002704)3.51152792
56negative regulation of erythrocyte differentiation (GO:0045647)3.44275146
57negative regulation of T cell mediated immunity (GO:0002710)3.42645286
58interferon-gamma-mediated signaling pathway (GO:0060333)3.39684088
59leukocyte degranulation (GO:0043299)3.38380623
60regulation of tolerance induction (GO:0002643)3.35156269
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34680794
62antigen processing and presentation via MHC class Ib (GO:0002475)3.33532906
63lipopolysaccharide-mediated signaling pathway (GO:0031663)3.33376586
64positive regulation of B cell differentiation (GO:0045579)3.31155564
65regulation of T cell tolerance induction (GO:0002664)3.30998651
66defense response to protozoan (GO:0042832)3.30681627
67cellular response to type I interferon (GO:0071357)3.25002825
68type I interferon signaling pathway (GO:0060337)3.25002825
69regulation of gamma-delta T cell differentiation (GO:0045586)3.24556336
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24284375
71positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.23485093
72production of molecular mediator involved in inflammatory response (GO:0002532)3.23015836
73response to type I interferon (GO:0034340)3.21993839
74regulation of regulated secretory pathway (GO:1903305)3.20299331
75B cell receptor signaling pathway (GO:0050853)3.18756486
76positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18673552
77regulation of B cell differentiation (GO:0045577)3.15546620
78myeloid leukocyte mediated immunity (GO:0002444)3.14464386
79regulation of T-helper 2 cell differentiation (GO:0045628)3.13293572
80response to interleukin-15 (GO:0070672)3.12342002
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10429811
82regulation of antigen processing and presentation (GO:0002577)3.09774683
83negative regulation of cytokine production involved in immune response (GO:0002719)3.06133532
84germinal center formation (GO:0002467)3.06104898
85positive regulation of antigen processing and presentation (GO:0002579)3.05713033
86negative regulation of interleukin-6 production (GO:0032715)3.04829663
87response to protozoan (GO:0001562)2.99285947
88negative regulation of phagocytosis (GO:0050765)2.98560643
89myeloid leukocyte activation (GO:0002274)2.97113663
90positive regulation of interferon-alpha production (GO:0032727)2.95233432
91neutrophil chemotaxis (GO:0030593)2.92579570
92positive thymic T cell selection (GO:0045059)2.86452851
93positive regulation of cellular amide metabolic process (GO:0034250)2.86176682
94negative regulation of innate immune response (GO:0045824)2.85759167
95regulation of interferon-alpha production (GO:0032647)2.85394265
96neutrophil migration (GO:1990266)2.85159455
97positive regulation of leukocyte degranulation (GO:0043302)2.84988612
98positive regulation of type 2 immune response (GO:0002830)2.82785837
99positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.82494536
100T-helper 1 type immune response (GO:0042088)2.81051972

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.89284003
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.05378346
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.46010106
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.82422483
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.36575511
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32169953
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.28435568
8VDR_21846776_ChIP-Seq_THP-1_Human3.05856075
9* SPI1_23547873_ChIP-Seq_NB4_Human2.94890812
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93459516
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.92391324
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.88459874
13VDR_24763502_ChIP-Seq_THP-1_Human2.87983125
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.79190046
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68810866
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.67413471
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66279134
18SPI1_23127762_ChIP-Seq_K562_Human2.60111558
19SCL_19346495_ChIP-Seq_HPC-7_Human2.59377828
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.51640718
21RUNX_20019798_ChIP-Seq_JUKART_Human2.42847844
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.39402056
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.37120075
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.35281498
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.31954986
26MAF_26560356_Chip-Seq_TH1_Human2.28755605
27MYB_26560356_Chip-Seq_TH2_Human2.28141863
28BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23609208
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14171419
30MYC_22102868_ChIP-Seq_BL_Human2.14129222
31UTX_26944678_Chip-Seq_JUKART_Human2.10532583
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06972521
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.98391611
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.98367193
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91140037
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90834264
37MYB_26560356_Chip-Seq_TH1_Human1.89352991
38TCF7_22412390_ChIP-Seq_EML_Mouse1.85286589
39VDR_24787735_ChIP-Seq_THP-1_Human1.83705959
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82077421
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77945578
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77838979
43MAF_26560356_Chip-Seq_TH2_Human1.71759454
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70252144
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69852320
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67030484
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66370148
48KDM2B_26808549_Chip-Seq_DND41_Human1.59484488
49GATA3_27048872_Chip-Seq_THYMUS_Human1.59326221
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58749446
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54761604
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.53814426
53TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51841586
54CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43562283
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43068531
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42014797
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37162343
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37038079
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36751809
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36528410
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.36346239
62PU_27001747_Chip-Seq_BMDM_Mouse1.33227182
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.33153532
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33135850
65SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33055712
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29497685
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29364877
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29194433
69GATA3_26560356_Chip-Seq_TH2_Human1.26925882
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.25945234
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25842208
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24896162
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.24546149
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24435072
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.22187307
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20737363
77LXR_22292898_ChIP-Seq_THP-1_Human1.20582114
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20378097
79GATA1_19941826_ChIP-Seq_K562_Human1.18781268
80BCL6_27268052_Chip-Seq_Bcells_Human1.17187402
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16678075
82GATA1_22025678_ChIP-Seq_K562_Human1.16560842
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14875436
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14333886
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12500470
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07074725
87BCOR_27268052_Chip-Seq_Bcells_Human1.06946229
88TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03168184
89KDM2B_26808549_Chip-Seq_JURKAT_Human0.97540219
90RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96120129
91SPI1_20517297_ChIP-Seq_HL60_Human0.95405596
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.94153210
93NCOR1_26117541_ChIP-Seq_K562_Human0.92762909
94NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90674890
95GATA2_19941826_ChIP-Seq_K562_Human0.90597372
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.89867255
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85775615
98STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85223765
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85047540
100STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83880354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.68096677
2MP0003436_decreased_susceptibility_to4.19714945
3MP0001835_abnormal_antigen_presentation4.05557896
4MP0003303_peritoneal_inflammation4.00916480
5MP0002419_abnormal_innate_immunity3.31963025
6MP0009785_altered_susceptibility_to3.01988942
7MP0005025_abnormal_response_to2.99898637
8MP0005671_abnormal_response_to2.95697493
9MP0005000_abnormal_immune_tolerance2.92414106
10MP0006082_CNS_inflammation2.90209691
11MP0001800_abnormal_humoral_immune2.83222658
12MP0001790_abnormal_immune_system2.81815823
13MP0005387_immune_system_phenotype2.81815823
14MP0000685_abnormal_immune_system2.65563532
15MP0002148_abnormal_hypersensitivity_rea2.63553285
16MP0002723_abnormal_immune_serum2.59687224
17MP0002452_abnormal_antigen_presenting2.57361183
18MP0002420_abnormal_adaptive_immunity2.53044692
19MP0001819_abnormal_immune_cell2.50619452
20MP0005464_abnormal_platelet_physiology2.35430681
21MP0003300_gastrointestinal_ulcer2.25634882
22MP0001533_abnormal_skeleton_physiology2.13093401
23MP0003191_abnormal_cellular_cholesterol2.07845948
24MP0003172_abnormal_lysosome_physiology2.04671027
25MP0009278_abnormal_bone_marrow2.03775448
26MP0002405_respiratory_system_inflammati2.02494353
27MP0008260_abnormal_autophagy1.91994591
28MP0003763_abnormal_thymus_physiology1.91975060
29MP0002398_abnormal_bone_marrow1.90428087
30MP0000465_gastrointestinal_hemorrhage1.88982344
31MP0000716_abnormal_immune_system1.87493497
32MP0001845_abnormal_inflammatory_respons1.83326969
33MP0010155_abnormal_intestine_physiology1.82198039
34MP0005058_abnormal_lysosome_morphology1.80592132
35MP0002132_abnormal_respiratory_system1.79106194
36MP0003828_pulmonary_edema1.78862718
37MP0004947_skin_inflammation1.65257063
38MP0005397_hematopoietic_system_phenotyp1.63441756
39MP0001545_abnormal_hematopoietic_system1.63441756
40MP0003075_altered_response_to1.62049761
41MP0009764_decreased_sensitivity_to1.60775433
42MP0000689_abnormal_spleen_morphology1.58636641
43MP0002722_abnormal_immune_system1.55975618
44MP0008469_abnormal_protein_level1.55064040
45MP0009333_abnormal_splenocyte_physiolog1.53465144
46MP0002429_abnormal_blood_cell1.50296623
47MP0003183_abnormal_peptide_metabolism1.48858833
48MP0002396_abnormal_hematopoietic_system1.44206597
49MP0003806_abnormal_nucleotide_metabolis1.43679713
50MP0003866_abnormal_defecation1.37023387
51MP0005310_abnormal_salivary_gland1.35435420
52MP0004510_myositis1.35432037
53MP0000858_altered_metastatic_potential1.27981253
54MP0002998_abnormal_bone_remodeling1.27409789
55MP0001851_eye_inflammation1.27061372
56MP0000703_abnormal_thymus_morphology1.25694229
57MP0005451_abnormal_body_composition1.22269464
58MP0005166_decreased_susceptibility_to1.18651053
59MP0004883_abnormal_blood_vessel1.18246426
60MP0008004_abnormal_stomach_pH1.15580098
61MP0002277_abnormal_respiratory_mucosa1.13736683
62MP0000343_altered_response_to1.11313530
63MP0003690_abnormal_glial_cell1.06903147
64MP0004381_abnormal_hair_follicle1.01926849
65MP0001853_heart_inflammation1.01743232
66MP0002166_altered_tumor_susceptibility1.01690264
67MP0001873_stomach_inflammation1.01520641
68MP0004808_abnormal_hematopoietic_stem0.95914962
69MP0005164_abnormal_response_to0.95017956
70MP0003656_abnormal_erythrocyte_physiolo0.93035991
71MP0003448_altered_tumor_morphology0.92569445
72MP0001663_abnormal_digestive_system0.92306119
73MP0005390_skeleton_phenotype0.90518970
74MP0009763_increased_sensitivity_to0.90127818
75MP0005075_abnormal_melanosome_morpholog0.89947431
76MP0000604_amyloidosis0.87445421
77MP0002138_abnormal_hepatobiliary_system0.86205269
78MP0000490_abnormal_crypts_of0.78044480
79MP0001986_abnormal_taste_sensitivity0.75635456
80MP0009765_abnormal_xenobiotic_induced0.72266305
81MP0000015_abnormal_ear_pigmentation0.68217935
82MP0003795_abnormal_bone_structure0.67755407
83MP0002006_tumorigenesis0.64645059
84MP0005319_abnormal_enzyme/_coenzyme0.60456810
85MP0009840_abnormal_foam_cell0.60046567
86MP0000249_abnormal_blood_vessel0.59188623
87MP0002933_joint_inflammation0.58341974
88MP0008874_decreased_physiological_sensi0.54637990
89MP0003045_fibrosis0.51892830
90MP0002009_preneoplasia0.51660860
91MP0002332_abnormal_exercise_endurance0.51591995
92MP0005535_abnormal_body_temperature0.49703459
93MP0005083_abnormal_biliary_tract0.49058653
94MP0005381_digestive/alimentary_phenotyp0.47895372
95MP0006054_spinal_hemorrhage0.47597420
96MP0002019_abnormal_tumor_incidence0.47225725
97MP0005084_abnormal_gallbladder_morpholo0.46843447
98MP0002693_abnormal_pancreas_physiology0.45347355
99MP0000920_abnormal_myelination0.43507583
100MP0003091_abnormal_cell_migration0.42715875

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.57200613
2Recurrent abscess formation (HP:0002722)6.26654387
3Recurrent bacterial skin infections (HP:0005406)6.21137529
4Abnormality of macrophages (HP:0004311)5.88733865
5Myositis (HP:0100614)5.63527572
6Stomatitis (HP:0010280)5.21651474
7Orchitis (HP:0100796)5.17753172
8Recurrent gram-negative bacterial infections (HP:0005420)5.08956075
9Optic neuritis (HP:0100653)4.90282852
10Retrobulbar optic neuritis (HP:0100654)4.90282852
11Elevated erythrocyte sedimentation rate (HP:0003565)4.76982640
12Obstructive lung disease (HP:0006536)4.40533364
13Chronic obstructive pulmonary disease (HP:0006510)4.40533364
14Mediastinal lymphadenopathy (HP:0100721)4.25155020
15Recurrent fungal infections (HP:0002841)4.24909829
16Recurrent skin infections (HP:0001581)4.16444295
17Meningitis (HP:0001287)4.03276907
18Abnormal delayed hypersensitivity skin test (HP:0002963)3.86447033
19Recurrent cutaneous fungal infections (HP:0011370)3.78604079
20Chronic mucocutaneous candidiasis (HP:0002728)3.78604079
21Gastrointestinal infarctions (HP:0005244)3.78485416
22Urticaria (HP:0001025)3.65212721
23Keratoconjunctivitis sicca (HP:0001097)3.57224684
24Prolonged bleeding time (HP:0003010)3.56084244
25Encephalitis (HP:0002383)3.55603002
26Gingivitis (HP:0000230)3.48148869
27Vasculitis (HP:0002633)3.38749277
28Spontaneous hematomas (HP:0007420)3.36416496
29Cellulitis (HP:0100658)3.31631785
30Increased IgE level (HP:0003212)3.29746351
31Keratoconjunctivitis (HP:0001096)3.29650044
32Episodic fever (HP:0001954)3.25149396
33Hypochromic microcytic anemia (HP:0004840)3.19520345
34Petechiae (HP:0000967)3.17199494
35Amyloidosis (HP:0011034)3.15497528
36Chest pain (HP:0100749)3.10119295
37Abnormality of glycolipid metabolism (HP:0010969)3.03520028
38Abnormality of liposaccharide metabolism (HP:0010968)3.03520028
39Abnormality of glycosphingolipid metabolism (HP:0004343)3.03520028
40Hemoptysis (HP:0002105)3.02951001
41Pulmonary infiltrates (HP:0002113)3.02620200
42Gingival bleeding (HP:0000225)2.96513515
43Recurrent viral infections (HP:0004429)2.95681905
44Epistaxis (HP:0000421)2.95216185
45Hypochromic anemia (HP:0001931)2.85545015
46Leukocytosis (HP:0001974)2.82019610
47Increased cerebral lipofuscin (HP:0011813)2.81929317
48Inflammation of the large intestine (HP:0002037)2.74125034
49Arterial thrombosis (HP:0004420)2.73546251
50Increased IgM level (HP:0003496)2.65228841
51Gastrointestinal inflammation (HP:0004386)2.63385171
52Panhypogammaglobulinemia (HP:0003139)2.62470213
53Purpura (HP:0000979)2.61989786
54Anorexia (HP:0002039)2.60565168
55Loss of speech (HP:0002371)2.57445644
56Pulmonary embolism (HP:0002204)2.57398089
57Osteomyelitis (HP:0002754)2.55853067
58Pustule (HP:0200039)2.47856458
59T lymphocytopenia (HP:0005403)2.47347028
60Peritonitis (HP:0002586)2.45399552
61Abnormality of T cell number (HP:0011839)2.41221594
62Increased serum ferritin (HP:0003281)2.38720693
63Gangrene (HP:0100758)2.37941837
64Granulocytopenia (HP:0001913)2.37568543
65Abnormality of T cells (HP:0002843)2.36593686
66Hepatosplenomegaly (HP:0001433)2.35794060
67Colitis (HP:0002583)2.34880401
68Abnormality of the pleura (HP:0002103)2.31762899
69Increased neuronal autofluorescent lipopigment (HP:0002074)2.30503413
70Sepsis (HP:0100806)2.28609407
71Hypergammaglobulinemia (HP:0010702)2.22297894
72Abnormality of T cell physiology (HP:0011840)2.18942092
73Microcytic anemia (HP:0001935)2.18214178
74Abnormality of iron homeostasis (HP:0011031)2.17321250
75Vertigo (HP:0002321)2.16734837
76Disinhibition (HP:0000734)2.16604323
77Dysostosis multiplex (HP:0000943)2.16070925
78Agammaglobulinemia (HP:0004432)2.15456706
79Polyneuropathy (HP:0001271)2.12018053
80Vacuolated lymphocytes (HP:0001922)2.11774372
81Systemic lupus erythematosus (HP:0002725)2.07713506
82Glomerulopathy (HP:0100820)2.07331566
83Autoimmune thrombocytopenia (HP:0001973)2.06266167
84Abnormality of the peritoneum (HP:0002585)2.06105565
85Skin ulcer (HP:0200042)2.05182507
86Premature loss of primary teeth (HP:0006323)2.04404402
87Lymphopenia (HP:0001888)2.04283941
88Abnormality of the endocardium (HP:0004306)2.01425806
89Abnormal platelet volume (HP:0011876)1.98169554
90Acne (HP:0001061)1.93978910
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91553027
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.90062106
93Recurrent pneumonia (HP:0006532)1.88939449
94Skin rash (HP:0000988)1.88681557
95Acute hepatic failure (HP:0006554)1.86768137
96Chronic otitis media (HP:0000389)1.85717365
97Abnormality of the pericardium (HP:0001697)1.84804278
98Amaurosis fugax (HP:0100576)1.83585615
99Eosinophilia (HP:0001880)1.83123594
100Autoimmune hemolytic anemia (HP:0001890)1.82727857

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.02092662
2MAP4K13.61659098
3BLK3.31672004
4MAP2K33.11840410
5IRAK43.11224367
6FES2.83049433
7TYK22.72682867
8ERN12.63559715
9CSK2.61565233
10TNK22.42329122
11PRPF4B2.25012809
12GRK62.24707684
13ZAP702.15081261
14TAOK11.95705288
15BTK1.92944444
16MAP3K31.87907108
17FGR1.87853237
18SYK1.86456549
19JAK31.78896563
20HCK1.77861904
21MAP3K111.74855558
22TBK11.69415454
23TXK1.68163587
24IKBKE1.67317842
25CSF1R1.66631151
26MAP3K141.64273045
27KIT1.61556284
28LYN1.51441823
29CDK191.49333517
30EPHB11.48183810
31JAK21.34145543
32MAP3K131.33363070
33MAP3K11.30180251
34TAOK31.28831350
35SIK31.24165476
36BMPR21.20117215
37TAOK21.18988502
38LCK1.18883251
39JAK11.16924099
40MATK1.16332028
41MARK31.11829718
42TEC1.10648114
43IKBKB1.10100568
44KSR21.04184714
45ITK1.01555921
46YES10.98987568
47TESK20.94023674
48PDK10.92285712
49IRAK20.89870570
50MARK20.88651456
51IRAK10.84406259
52STK100.82539448
53PRKD20.81974887
54PDPK10.81878341
55MAPK70.81194947
56MAP3K60.79876570
57GRK70.73003345
58IRAK30.72131765
59TGFBR20.67100234
60SIK20.65526990
61PTK60.65065996
62MAP3K50.64175398
63PIK3CG0.63987736
64FYN0.63156508
65NLK0.62288317
66LRRK20.56738227
67MAPK120.56355864
68MOS0.54296024
69RPS6KC10.52717952
70RPS6KL10.52717952
71MAP2K40.51235419
72DYRK1B0.51227239
73SGK30.50797856
74PIM10.49892849
75HIPK20.49541912
76PRKCQ0.48259316
77CDC42BPA0.47687290
78TRIB30.44790654
79RPS6KA60.44370637
80DAPK20.43961016
81PTK2B0.43924804
82MAP3K70.43763454
83STK110.43206532
84MAP2K60.38681912
85MAP3K20.38674501
86SGK20.36662996
87MAPKAPK20.35927658
88SMG10.35116795
89RAF10.33203404
90CDK40.33063482
91PRKCD0.32543746
92ABL10.30110965
93MAP2K20.30020419
94SIK10.28753552
95CDK60.27234439
96RET0.26047742
97BCKDK0.25773786
98MAPK40.25621460
99KSR10.24677037
100MAP3K80.24033699

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.31622009
2Staphylococcus aureus infection_Homo sapiens_hsa051503.15079474
3Osteoclast differentiation_Homo sapiens_hsa043803.00273995
4Allograft rejection_Homo sapiens_hsa053302.82925622
5Graft-versus-host disease_Homo sapiens_hsa053322.78668083
6Autoimmune thyroid disease_Homo sapiens_hsa053202.58814951
7Asthma_Homo sapiens_hsa053102.33894314
8Tuberculosis_Homo sapiens_hsa051522.30083722
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.13645066
10Type I diabetes mellitus_Homo sapiens_hsa049402.12593855
11B cell receptor signaling pathway_Homo sapiens_hsa046622.06392332
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.05823104
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02854774
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02691566
15Antigen processing and presentation_Homo sapiens_hsa046121.95900551
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.92212655
17Malaria_Homo sapiens_hsa051441.92165840
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90171243
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.89878761
20Hematopoietic cell lineage_Homo sapiens_hsa046401.87241635
21Primary immunodeficiency_Homo sapiens_hsa053401.83441171
22Legionellosis_Homo sapiens_hsa051341.74321786
23Viral myocarditis_Homo sapiens_hsa054161.72218096
24Other glycan degradation_Homo sapiens_hsa005111.71275261
25Toxoplasmosis_Homo sapiens_hsa051451.58669384
26Influenza A_Homo sapiens_hsa051641.57490492
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.56676019
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.54590312
29Measles_Homo sapiens_hsa051621.54477065
30Phagosome_Homo sapiens_hsa041451.53806166
31Chemokine signaling pathway_Homo sapiens_hsa040621.52016861
32Rheumatoid arthritis_Homo sapiens_hsa053231.50072668
33Acute myeloid leukemia_Homo sapiens_hsa052211.46430567
34Herpes simplex infection_Homo sapiens_hsa051681.44003376
35African trypanosomiasis_Homo sapiens_hsa051431.36573732
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36012025
37Pertussis_Homo sapiens_hsa051331.31810043
38T cell receptor signaling pathway_Homo sapiens_hsa046601.30082103
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24224089
40TNF signaling pathway_Homo sapiens_hsa046681.22224251
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.19970307
42Salmonella infection_Homo sapiens_hsa051321.17236061
43Platelet activation_Homo sapiens_hsa046111.17106201
44Lysosome_Homo sapiens_hsa041421.15714412
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09780778
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.07636469
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05935778
48Shigellosis_Homo sapiens_hsa051311.05487133
49Hepatitis B_Homo sapiens_hsa051611.02202466
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92239067
51Hepatitis C_Homo sapiens_hsa051600.91695734
52Glycosaminoglycan degradation_Homo sapiens_hsa005310.90386401
53Non-small cell lung cancer_Homo sapiens_hsa052230.88785460
54Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87787679
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82333125
56Apoptosis_Homo sapiens_hsa042100.79091318
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79048032
58Pancreatic cancer_Homo sapiens_hsa052120.74096404
59VEGF signaling pathway_Homo sapiens_hsa043700.71278073
60Epstein-Barr virus infection_Homo sapiens_hsa051690.70527269
61Chronic myeloid leukemia_Homo sapiens_hsa052200.69687209
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.66366512
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66203948
64Amoebiasis_Homo sapiens_hsa051460.65555573
65Endocytosis_Homo sapiens_hsa041440.65024119
66Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63986813
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.62789035
68Prolactin signaling pathway_Homo sapiens_hsa049170.60995473
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60883194
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.55517943
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54263530
72Renal cell carcinoma_Homo sapiens_hsa052110.52761283
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52725484
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.51185302
75Viral carcinogenesis_Homo sapiens_hsa052030.50358130
76HTLV-I infection_Homo sapiens_hsa051660.50209562
77Notch signaling pathway_Homo sapiens_hsa043300.50198216
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.47829401
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47274306
80FoxO signaling pathway_Homo sapiens_hsa040680.45512835
81GnRH signaling pathway_Homo sapiens_hsa049120.45132569
82Collecting duct acid secretion_Homo sapiens_hsa049660.43343221
83HIF-1 signaling pathway_Homo sapiens_hsa040660.42162774
84Choline metabolism in cancer_Homo sapiens_hsa052310.40654162
85Regulation of autophagy_Homo sapiens_hsa041400.40285842
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37994416
87Type II diabetes mellitus_Homo sapiens_hsa049300.37905991
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37609809
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35646431
90Systemic lupus erythematosus_Homo sapiens_hsa053220.34943841
91Dorso-ventral axis formation_Homo sapiens_hsa043200.34808814
92Insulin resistance_Homo sapiens_hsa049310.34790076
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34754160
94MAPK signaling pathway_Homo sapiens_hsa040100.34513498
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33388008
96Inositol phosphate metabolism_Homo sapiens_hsa005620.28554297
97mTOR signaling pathway_Homo sapiens_hsa041500.27245927
98Endometrial cancer_Homo sapiens_hsa052130.27224089
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26835503
100Colorectal cancer_Homo sapiens_hsa052100.26112454

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