ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of microtubule polymerization (GO:0031115)	7.50550928
2	positive regulation of mitochondrial calcium ion concentration (GO:0051561)	7.24089322
3	mitochondrial calcium ion transport (GO:0006851)	6.85137198
4	establishment of endothelial barrier (GO:0061028)	6.28037771
5	oligosaccharide catabolic process (GO:0009313)	5.80380083
6	peptidyl-proline hydroxylation (GO:0019511)	5.76081310
7	heparan sulfate proteoglycan biosynthetic process (GO:0015012)	5.70772771
8	protein localization to endosome (GO:0036010)	5.28795720
9	respiratory tube development (GO:0030323)	5.25335767
10	negative regulation of protein localization to plasma membrane (GO:1903077)	5.22824791
11	cardiovascular system development (GO:0072358)	4.99402674
12	endocardial cushion development (GO:0003197)	4.95855772
13	positive regulation of extracellular matrix organization (GO:1903055)	4.81423596
14	protein hydroxylation (GO:0018126)	4.50205080
15	protein localization to microtubule (GO:0035372)	4.48468693
16	pericardium development (GO:0060039)	4.33460915
17	endothelial cell development (GO:0001885)	4.25245225
18	mitochondrial calcium ion homeostasis (GO:0051560)	4.14231839
19	COPI coating of Golgi vesicle (GO:0048205)	4.14206903
20	Golgi transport vesicle coating (GO:0048200)	4.14206903
21	lymph vessel development (GO:0001945)	4.07469286
22	proteoglycan biosynthetic process (GO:0030166)	4.00030237
23	regulation of response to osmotic stress (GO:0047484)	3.96038370
24	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	3.95648248
25	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	3.95648248
26	regulation of NFAT protein import into nucleus (GO:0051532)	3.95225012
27	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.94281351
28	induction of positive chemotaxis (GO:0050930)	3.91855756
29	glycosphingolipid catabolic process (GO:0046479)	3.83964820
30	hemoglobin metabolic process (GO:0020027)	3.77340848
31	negative regulation of androgen receptor signaling pathway (GO:0060766)	3.76752375
32	negative regulation of osteoblast proliferation (GO:0033689)	3.76451504
33	actin filament capping (GO:0051693)	3.75580336
34	negative regulation of cell size (GO:0045792)	3.73690806
35	4-hydroxyproline metabolic process (GO:0019471)	3.68460137
36	sialylation (GO:0097503)	3.67534395
37	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.67528921
38	establishment of apical/basal cell polarity (GO:0035089)	3.66494230
39	response to misfolded protein (GO:0051788)	3.66208281
40	lateral ventricle development (GO:0021670)	3.65368485
41	cellular response to ammonium ion (GO:0071242)	3.61226644
42	substrate-dependent cell migration (GO:0006929)	3.61125403
43	polarized epithelial cell differentiation (GO:0030859)	3.60853281
44	termination of RNA polymerase I transcription (GO:0006363)	3.58808899
45	negative regulation of muscle hypertrophy (GO:0014741)	3.44047851
46	regulation of extracellular matrix disassembly (GO:0010715)	3.42242292
47	regulation of lymphocyte migration (GO:2000401)	3.41761922
48	glycolipid catabolic process (GO:0019377)	3.40101636
49	maternal placenta development (GO:0001893)	3.36475664
50	pinocytosis (GO:0006907)	3.36110230
51	regulation of mitotic spindle organization (GO:0060236)	3.33315523
52	pre-miRNA processing (GO:0031054)	3.32633316
53	negative regulation of actin filament depolymerization (GO:0030835)	3.29711197
54	heparan sulfate proteoglycan metabolic process (GO:0030201)	3.28850999
55	glucose 6-phosphate metabolic process (GO:0051156)	3.24237019
56	establishment of monopolar cell polarity (GO:0061162)	3.24074394
57	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.24074394
58	lymphangiogenesis (GO:0001946)	3.21785749
59	lung vasculature development (GO:0060426)	3.21198545
60	vascular endothelial growth factor signaling pathway (GO:0038084)	3.19645753
61	transcription initiation from RNA polymerase I promoter (GO:0006361)	3.16873250
62	somatic stem cell division (GO:0048103)	3.15421710
63	negative regulation of microtubule polymerization or depolymerization (GO:0031111)	3.10338819
64	negative regulation of necroptotic process (GO:0060546)	3.07992716
65	regulation of exit from mitosis (GO:0007096)	3.07276066
66	glycoprotein biosynthetic process (GO:0009101)	3.05527591
67	lung morphogenesis (GO:0060425)	3.03173971
68	regulation of protein kinase C signaling (GO:0090036)	3.00340785
69	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.99463154
70	positive regulation of fibroblast migration (GO:0010763)	2.96446593
71	CDP-diacylglycerol metabolic process (GO:0046341)	2.96125873
72	regulation of monocyte chemotaxis (GO:0090025)	2.92604099
73	regulation of glucocorticoid metabolic process (GO:0031943)	2.92207924
74	ceramide catabolic process (GO:0046514)	2.91002847
75	regulation of protein localization to plasma membrane (GO:1903076)	2.89562930
76	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.89043606
77	establishment of epithelial cell polarity (GO:0090162)	2.88683600
78	regulation of monocyte differentiation (GO:0045655)	2.88534238
79	enteric nervous system development (GO:0048484)	2.87635967
80	mammary gland epithelial cell differentiation (GO:0060644)	2.86696582
81	response to muramyl dipeptide (GO:0032495)	2.86624925
82	positive regulation of actin cytoskeleton reorganization (GO:2000251)	2.83044687
83	regulation of microtubule polymerization (GO:0031113)	2.81338748
84	NIK/NF-kappaB signaling (GO:0038061)	2.80909639
85	blood vessel maturation (GO:0001955)	2.79619389
86	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.77420155
87	transcription from RNA polymerase I promoter (GO:0006360)	2.76888657
88	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.71776527
89	SMAD protein complex assembly (GO:0007183)	2.71562578
90	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.70739740
91	cell volume homeostasis (GO:0006884)	2.70339878
92	cellular hyperosmotic response (GO:0071474)	2.69636935
93	negative regulation of Notch signaling pathway (GO:0045746)	2.69041688
94	renal system development (GO:0072001)	2.68150636
95	negative regulation of erythrocyte differentiation (GO:0045647)	2.66592614
96	chondroitin sulfate biosynthetic process (GO:0030206)	2.66257401
97	urinary tract smooth muscle contraction (GO:0014848)	2.66070006
98	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.65520659
99	leukocyte cell-cell adhesion (GO:0007159)	2.65049348
100	barbed-end actin filament capping (GO:0051016)	12.1541469

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	3.93113285
2	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.81967491
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.55556728
4	MYC_22102868_ChIP-Seq_BL_Human	2.55376900
5	VDR_21846776_ChIP-Seq_THP-1_Human	2.54264140
6	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.49437433
7	LXR_22292898_ChIP-Seq_THP-1_Human	2.43155798
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.36176264
9	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.25283654
10	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.25064884
11	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.20970718
12	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.11874667
13	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.10153058
14	RACK7_27058665_Chip-Seq_MCF-7_Human	2.08778809
15	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.07093960
16	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.98371380
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.98103062
18	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.92158291
19	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.87264374
20	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.82277992
21	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.79002192
22	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.77654685
23	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.75950441
24	KDM2B_26808549_Chip-Seq_DND41_Human	1.75775728
25	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.64515849
26	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.61237099
27	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.58518888
28	VDR_24763502_ChIP-Seq_THP-1_Human	1.57540761
29	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.52894723
30	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.52412065
31	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.51940978
32	UTX_26944678_Chip-Seq_JUKART_Human	1.50796437
33	KDM2B_26808549_Chip-Seq_K562_Human	1.50704880
34	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.49968771
35	* CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.49085293
36	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.47136683
37	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.45985294
38	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.45627875
39	TP53_22127205_ChIP-Seq_IMR90_Human	1.45446306
40	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.44209562
41	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.43706914
42	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.39324719
43	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.39175381
44	MAF_26560356_Chip-Seq_TH2_Human	1.39130796
45	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.38501558
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37550907
47	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.36191171
48	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.33979559
49	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.33386708
50	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.32605768
51	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.32173926
52	CIITA_25753668_ChIP-Seq_RAJI_Human	1.31924859
53	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.31436433
54	TCF7_22412390_ChIP-Seq_EML_Mouse	1.31422761
55	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.29409281
56	MAF_26560356_Chip-Seq_TH1_Human	1.28240536
57	CLOCK_20551151_ChIP-Seq_293T_Human	1.27033921
58	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.25062555
59	* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.23421611
60	* CTCF_21964334_Chip-Seq_Bcells_Human	1.19583136
61	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.19338527
62	XRN2_22483619_ChIP-Seq_HELA_Human	1.18267362
63	P68_20966046_ChIP-Seq_HELA_Human	1.18178208
64	ATF3_27146783_Chip-Seq_COLON_Human	1.17347375
65	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.17342032
66	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.16864888
67	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.15260630
68	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.14809055
69	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.14474800
70	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.13755766
71	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.13286495
72	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.12405453
73	SPI1_23127762_ChIP-Seq_K562_Human	1.11594407
74	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.11233425
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.10796607
76	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.09481791
77	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.07632101
78	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.06932725
79	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06911033
80	CREB1_26743006_Chip-Seq_LNCaP_Human	1.06096850
81	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.05684720
82	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.05169333
83	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.04485847
84	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04226833
85	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.03763412
86	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.00827248
87	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.00791456
88	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.99466539
89	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.99462920
90	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.98002151
91	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.97824087
92	SMC4_20622854_ChIP-Seq_HELA_Human	0.97313447
93	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.97067473
94	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.97054799
95	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97032043
96	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.95689931
97	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.95069052
98	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.94370938
99	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.94240928
100	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.92035316

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003950_abnormal_plasma_membrane	9.86892658
2	MP0008961_abnormal_basal_metabolism	5.01774505
3	MP0002653_abnormal_ependyma_morphology	4.51453109
4	MP0004233_abnormal_muscle_weight	4.20898816
5	MP0009379_abnormal_foot_pigmentation	3.83017566
6	MP0003705_abnormal_hypodermis_morpholog	3.15908618
7	MP0005451_abnormal_body_composition	3.14225104
8	MP0003959_abnormal_lean_body	2.91642304
9	MP0005409_darkened_coat_color	2.89894600
10	MP0001346_abnormal_lacrimal_gland	2.79498309
11	MP0005257_abnormal_intraocular_pressure	2.76470630
12	MP0005623_abnormal_meninges_morphology	2.57388733
13	MP0010368_abnormal_lymphatic_system	2.17287841
14	MP0003828_pulmonary_edema	2.12261333
15	MP0009384_cardiac_valve_regurgitation	1.85126712
16	MP0008438_abnormal_cutaneous_collagen	1.74778133
17	MP0000015_abnormal_ear_pigmentation	1.73488133
18	MP0000534_abnormal_ureter_morphology	1.72096903
19	MP0001188_hyperpigmentation	1.54791330
20	MP0003172_abnormal_lysosome_physiology	1.51780137
21	MP0003942_abnormal_urinary_system	1.47074080
22	MP0003303_peritoneal_inflammation	1.45418371
23	MP0009250_abnormal_appendicular_skeleto	1.41101251
24	MP0009278_abnormal_bone_marrow	1.39100063
25	MP0009840_abnormal_foam_cell	1.36396370
26	MP0004858_abnormal_nervous_system	1.22816017
27	MP0005058_abnormal_lysosome_morphology	1.20197590
28	MP0004185_abnormal_adipocyte_glucose	1.19712130
29	MP0005023_abnormal_wound_healing	1.15995839
30	MP0000678_abnormal_parathyroid_gland	1.15680801
31	MP0001849_ear_inflammation	1.14604824
32	MP0003191_abnormal_cellular_cholesterol	1.13530514
33	MP0002896_abnormal_bone_mineralization	1.06788566
34	MP0000733_abnormal_muscle_development	1.02612942
35	MP0003436_decreased_susceptibility_to	1.01122784
36	MP0000767_abnormal_smooth_muscle	0.93891383
37	MP0001299_abnormal_eye_distance/	0.91197811
38	MP0000858_altered_metastatic_potential	0.90429620
39	MP0001879_abnormal_lymphatic_vessel	0.87385645
40	MP0003091_abnormal_cell_migration	0.86330613
41	MP0003329_amyloid_beta_deposits	0.86000769
42	MP0002877_abnormal_melanocyte_morpholog	0.85490154
43	MP0000467_abnormal_esophagus_morphology	0.84691074
44	MP0001873_stomach_inflammation	0.84259176
45	MP0001958_emphysema	0.82608009
46	MP0000759_abnormal_skeletal_muscle	0.82361770
47	MP0006138_congestive_heart_failure	0.80887285
48	MP0005464_abnormal_platelet_physiology	0.80784720
49	MP0002249_abnormal_larynx_morphology	0.80382663
50	MP0003941_abnormal_skin_development	0.78251830
51	MP0008932_abnormal_embryonic_tissue	0.77160699
52	MP0008874_decreased_physiological_sensi	0.75015386
53	MP0002998_abnormal_bone_remodeling	0.73726592
54	MP0003566_abnormal_cell_adhesion	0.70605758
55	MP0004036_abnormal_muscle_relaxation	0.69147551
56	MP0001533_abnormal_skeleton_physiology	0.68354503
57	MP0005165_increased_susceptibility_to	0.68178096
58	MP0000685_abnormal_immune_system	0.67072167
59	MP0005076_abnormal_cell_differentiation	0.66401015
60	MP0004947_skin_inflammation	0.65799866
61	MP0001664_abnormal_digestion	0.64915977
62	MP0009672_abnormal_birth_weight	0.63262884
63	MP0000537_abnormal_urethra_morphology	0.62999451
64	MP0000490_abnormal_crypts_of	0.62763509
65	MP0003111_abnormal_nucleus_morphology	0.61936768
66	MP0004808_abnormal_hematopoietic_stem	0.60898499
67	MP0003075_altered_response_to	0.59738597
68	MP0005595_abnormal_vascular_smooth	0.58808746
69	MP0003453_abnormal_keratinocyte_physiol	0.58608391
70	MP0002295_abnormal_pulmonary_circulatio	0.57185320
71	MP0000350_abnormal_cell_proliferation	0.57019917
72	MP0002089_abnormal_postnatal_growth/wei	0.56068768
73	MP0008057_abnormal_DNA_replication	0.54509121
74	MP0005390_skeleton_phenotype	0.54367816
75	MP0002102_abnormal_ear_morphology	0.54235300
76	MP0005508_abnormal_skeleton_morphology	0.53654006
77	MP0003763_abnormal_thymus_physiology	0.53469762
78	MP0004272_abnormal_basement_membrane	0.52848884
79	MP0008770_decreased_survivor_rate	0.52842375
80	MP0001663_abnormal_digestive_system	0.52048661
81	MP0005501_abnormal_skin_physiology	0.51492603
82	MP0010030_abnormal_orbit_morphology	0.51266602
83	MP0002127_abnormal_cardiovascular_syste	0.51209830
84	MP0002111_abnormal_tail_morphology	0.50821066
85	MP0002269_muscular_atrophy	0.50653332
86	MP0005187_abnormal_penis_morphology	0.49893445
87	MP0009053_abnormal_anal_canal	0.49376091
88	MP0001542_abnormal_bone_strength	0.49192878
89	MP0005397_hematopoietic_system_phenotyp	0.48677140
90	MP0001545_abnormal_hematopoietic_system	0.48677140
91	MP0000749_muscle_degeneration	0.48584707
92	MP0002113_abnormal_skeleton_development	0.48223030
93	MP0002114_abnormal_axial_skeleton	0.47507365
94	MP0002080_prenatal_lethality	0.47329902
95	MP0001790_abnormal_immune_system	0.47206720
96	MP0005387_immune_system_phenotype	0.47206720
97	MP0005174_abnormal_tail_pigmentation	0.46861415
98	MP0005666_abnormal_adipose_tissue	0.46074675
99	MP0001727_abnormal_embryo_implantation	0.46039524
100	MP0002405_respiratory_system_inflammati	0.46013335

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Spinal rigidity (HP:0003306)	5.88717064
2	Muscle stiffness (HP:0003552)	5.24446352
3	Myotonia (HP:0002486)	5.15545963
4	Protrusio acetabuli (HP:0003179)	4.97928394
5	IgA deficiency (HP:0002720)	4.92320375
6	Abnormality of carpal bone ossification (HP:0006257)	4.89141601
7	Genu recurvatum (HP:0002816)	4.47573747
8	Gastrointestinal dysmotility (HP:0002579)	4.32239070
9	Abnormal ossification of hand bones (HP:0005921)	3.83917767
10	Syringomyelia (HP:0003396)	3.82985723
11	Spinal cord lesions (HP:0100561)	3.82985723
12	Cervical subluxation (HP:0003308)	3.82555515
13	Prolonged QT interval (HP:0001657)	3.82438784
14	Relative macrocephaly (HP:0004482)	3.75786044
15	Cupped ribs (HP:0000887)	3.72576881
16	Abnormal hand bone ossification (HP:0010660)	3.59398306
17	Bradycardia (HP:0001662)	3.53872681
18	Patellar dislocation (HP:0002999)	3.41193796
19	Epiphyseal dysplasia (HP:0002656)	3.39435711
20	Acanthosis nigricans (HP:0000956)	3.32121609
21	Cortical dysplasia (HP:0002539)	3.27143996
22	Abnormal umbilical cord blood vessels (HP:0011403)	3.20051493
23	Single umbilical artery (HP:0001195)	3.20051493
24	Abnormality of the fetal cardiovascular system (HP:0010948)	3.20051493
25	Vertebral compression fractures (HP:0002953)	3.16966004
26	Flared iliac wings (HP:0002869)	3.13993912
27	Generalized muscle weakness (HP:0003324)	3.09291072
28	Centrally nucleated skeletal muscle fibers (HP:0003687)	3.08110809
29	Spinal cord compression (HP:0002176)	3.02262054
30	Distal lower limb muscle weakness (HP:0009053)	3.00092752
31	Mesangial abnormality (HP:0001966)	2.99399475
32	Insulin resistance (HP:0000855)	2.93015323
33	Hypertriglyceridemia (HP:0002155)	2.92227836
34	Short clavicles (HP:0000894)	2.91398669
35	Arterial tortuosity (HP:0005116)	2.64528226
36	Aplasia/Hypoplasia of the clavicles (HP:0006710)	2.57337588
37	Back pain (HP:0003418)	2.55533918
38	Vascular tortuosity (HP:0004948)	2.54887545
39	Hypoplastic left heart (HP:0004383)	2.54490800
40	Spondylolisthesis (HP:0003302)	2.49581033
41	Abnormality of the pulmonary veins (HP:0011718)	2.49115532
42	Asymmetry of the thorax (HP:0001555)	2.46326748
43	Abnormality of the phalanges of the hallux (HP:0010057)	2.33976545
44	Hyperparathyroidism (HP:0000843)	2.24889193
45	Thin bony cortex (HP:0002753)	2.22888680
46	Short nail (HP:0001799)	2.22572773
47	Abnormality of the umbilical cord (HP:0010881)	2.22370372
48	Peripheral hypomyelination (HP:0007182)	2.20796117
49	Ovoid vertebral bodies (HP:0003300)	2.18754951
50	Muscular dystrophy (HP:0003560)	2.15267037
51	Premature rupture of membranes (HP:0001788)	2.15264887
52	Aortic aneurysm (HP:0004942)	2.14001358
53	Delayed cranial suture closure (HP:0000270)	2.10114905
54	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.09149816
55	Blue sclerae (HP:0000592)	2.09007268
56	Abnormal gallbladder physiology (HP:0012438)	2.07680029
57	Cholecystitis (HP:0001082)	2.07680029
58	Hyperacusis (HP:0010780)	2.07220823
59	Zonular cataract (HP:0010920)	2.04466337
60	Atrial fibrillation (HP:0005110)	2.04383542
61	Bell-shaped thorax (HP:0001591)	2.00803828
62	Annular pancreas (HP:0001734)	2.00129820
63	Ileus (HP:0002595)	10.5200136
64	Distal lower limb amyotrophy (HP:0008944)	1.98214617
65	Coxa vara (HP:0002812)	1.97385814
66	Aneurysm (HP:0002617)	1.94974400
67	Mitral regurgitation (HP:0001653)	1.93911254
68	Osteopenia (HP:0000938)	1.93028169
69	Supraventricular tachycardia (HP:0004755)	1.91518652
70	Abnormality of the acetabulum (HP:0003170)	1.87034426
71	Hypoplastic heart (HP:0001961)	1.85558177
72	Hypoventilation (HP:0002791)	1.84790685
73	Supraventricular arrhythmia (HP:0005115)	1.84587211
74	Abnormal EKG (HP:0003115)	1.84454169
75	Biconcave vertebral bodies (HP:0004586)	1.84232647
76	Primary atrial arrhythmia (HP:0001692)	1.84177404
77	Abnormality of dentin (HP:0010299)	1.83548790
78	Buphthalmos (HP:0000557)	1.83467837
79	Joint stiffness (HP:0001387)	1.81818807
80	Flared metaphyses (HP:0003015)	1.80123937
81	Hydroureter (HP:0000072)	1.79389365
82	Skin nodule (HP:0200036)	1.79199847
83	Joint laxity (HP:0001388)	1.77963164
84	Insomnia (HP:0100785)	1.75031053
85	Broad phalanx (HP:0006009)	1.74377479
86	Abnormality of skeletal muscle fiber size (HP:0012084)	1.74187970
87	Broad long bones (HP:0005622)	1.72040511
88	Flat face (HP:0012368)	1.71810902
89	Dysostosis multiplex (HP:0000943)	1.71781430
90	Multiple lipomas (HP:0001012)	1.71576503
91	Hirsutism (HP:0001007)	1.71014486
92	Hypertensive crisis (HP:0100735)	1.67113069
93	Loss of speech (HP:0002371)	1.66119068
94	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.65675822
95	Abnormality of polysaccharide metabolism (HP:0011012)	1.65675822
96	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.65675822
97	Broad metatarsal (HP:0001783)	1.65443480
98	Congenital glaucoma (HP:0001087)	1.63984458
99	Mucopolysacchariduria (HP:0008155)	1.62655405
100	Urinary glycosaminoglycan excretion (HP:0003541)	1.62655405

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK10	7.37414018
2	LRRK2	5.46219561
3	TRIB3	4.36374553
4	DDR2	3.37940346
5	PNCK	3.16824880
6	VRK2	3.15572766
7	PKN2	2.92998892
8	CAMK1G	2.48673522
9	MAP3K8	2.37732448
10	ROCK2	2.23657382
11	RIPK1	2.00242018
12	EEF2K	1.99932780
13	ERN1	1.86795189
14	EIF2AK1	1.78717448
15	CDK8	1.77427900
16	ADRBK1	1.67903797
17	PRKG2	1.62136269
18	PIM2	1.61973697
19	NTRK1	1.42597427
20	PAK4	1.35654381
21	SMG1	1.31529334
22	ROCK1	1.30657117
23	PRKD2	1.27622018
24	CAMK1	1.21138323
25	CAMK4	1.11242368
26	PRPF4B	1.10373014
27	PRKD3	1.04656171
28	TESK1	1.01117106
29	MTOR	1.00767982
30	MARK2	0.97852137
31	ARAF	0.97344674
32	WNK1	0.97306730
33	MAP3K10	0.95891842
34	MAP2K3	0.95527164
35	STK16	0.92282892
36	PDGFRA	0.91308686
37	PRKCQ	0.85549400
38	MAP3K13	0.84511405
39	MAPKAPK3	0.81564952
40	IRAK3	0.80171202
41	MELK	0.78871554
42	NME2	0.78498164
43	WNK4	0.76987245
44	CDK4	0.74837023
45	PDGFRB	0.72407029
46	ALK	0.71430625
47	TESK2	0.67895461
48	CDK9	0.67265823
49	MAP3K3	0.66713236
50	PAK6	0.64527504
51	PTK2	0.62733224
52	TAOK2	0.62560233
53	TBK1	0.61157451
54	PRKCZ	0.59724491
55	CAMKK1	0.56181608
56	CAMK1D	0.55706124
57	AURKB	0.53919843
58	EPHB2	0.52521039
59	PAK1	0.52063914
60	ICK	0.50581084
61	CDC42BPA	0.49738587
62	MAP2K1	0.48716486
63	PAK2	0.44813504
64	KSR2	0.44364618
65	MAP3K11	0.43683779
66	ZAP70	0.43622862
67	EPHB1	0.43147813
68	MAP3K7	0.40324361
69	STK38	0.39415841
70	MAP2K2	0.39305288
71	GRK6	0.38490098
72	CAMK2G	0.37336831
73	CDK7	0.37283978
74	MOS	0.36215123
75	ILK	0.34579991
76	SRPK1	0.34419748
77	PTK6	0.32932117
78	MAP4K1	0.31871118
79	AKT3	0.30257037
80	RPS6KA2	0.29825924
81	MAP3K5	0.28246461
82	FES	0.28171609
83	TAOK1	0.27328316
84	TYRO3	0.27232090
85	DAPK3	0.27153545
86	MYLK	0.26592748
87	MAPK11	0.26242102
88	ABL2	0.26022538
89	TAF1	0.25997912
90	PRKD1	0.25771080
91	PRKACG	0.25747371
92	PDPK1	0.24621968
93	SGK3	0.24591143
94	CDK3	0.24571179
95	SIK1	0.24448049
96	MAPKAPK5	0.24273812
97	RPS6KA1	0.23303078
98	EPHA2	0.22583121
99	BRAF	0.21711672
100	AURKA	0.20935341

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	5.15732100
2	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	5.09059318
3	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	4.24941294
4	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	3.44509591
5	Other glycan degradation_Homo sapiens_hsa00511	2.76480900
6	Notch signaling pathway_Homo sapiens_hsa04330	2.03128514
7	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.83088451
8	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.61085914
9	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.55505595
10	Sulfur relay system_Homo sapiens_hsa04122	1.53956380
11	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.52983387
12	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.45357861
13	Acute myeloid leukemia_Homo sapiens_hsa05221	1.42746916
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.42416896
15	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.41177202
16	Pancreatic cancer_Homo sapiens_hsa05212	1.41047171
17	Glioma_Homo sapiens_hsa05214	1.37096844
18	Non-small cell lung cancer_Homo sapiens_hsa05223	1.33457666
19	Endocytosis_Homo sapiens_hsa04144	1.27579499
20	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.23440368
21	Proteoglycans in cancer_Homo sapiens_hsa05205	1.22580202
22	Measles_Homo sapiens_hsa05162	1.21912754
23	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.19101321
24	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.18142658
25	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.17826579
26	Prostate cancer_Homo sapiens_hsa05215	1.14484611
27	Bladder cancer_Homo sapiens_hsa05219	1.09975796
28	ErbB signaling pathway_Homo sapiens_hsa04012	1.08779184
29	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.06685128
30	Hepatitis C_Homo sapiens_hsa05160	1.05704497
31	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.05011017
32	Thyroid cancer_Homo sapiens_hsa05216	1.01801326
33	Endometrial cancer_Homo sapiens_hsa05213	1.01063232
34	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.95999145
35	Gap junction_Homo sapiens_hsa04540	0.94483304
36	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.94399692
37	Shigellosis_Homo sapiens_hsa05131	0.93022671
38	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.92811143
39	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.92062984
40	Pentose phosphate pathway_Homo sapiens_hsa00030	0.91898557
41	VEGF signaling pathway_Homo sapiens_hsa04370	0.90798162
42	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.89402265
43	Prion diseases_Homo sapiens_hsa05020	0.84399264
44	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.83452267
45	Hepatitis B_Homo sapiens_hsa05161	0.82872126
46	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.79763667
47	Galactose metabolism_Homo sapiens_hsa00052	0.78884001
48	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.78199664
49	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.76785043
50	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.75853070
51	Adherens junction_Homo sapiens_hsa04520	0.73384339
52	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71771574
53	Melanogenesis_Homo sapiens_hsa04916	0.70967715
54	Focal adhesion_Homo sapiens_hsa04510	0.70354454
55	Colorectal cancer_Homo sapiens_hsa05210	0.69365238
56	Lysosome_Homo sapiens_hsa04142	0.67854089
57	Insulin signaling pathway_Homo sapiens_hsa04910	0.67565846
58	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64661119
59	Osteoclast differentiation_Homo sapiens_hsa04380	0.64535756
60	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63397623
61	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.63324165
62	Amoebiasis_Homo sapiens_hsa05146	0.63296220
63	Choline metabolism in cancer_Homo sapiens_hsa05231	0.62950195
64	Vibrio cholerae infection_Homo sapiens_hsa05110	0.61562908
65	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61499267
66	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.60611567
67	HTLV-I infection_Homo sapiens_hsa05166	0.59936006
68	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.59863114
69	Prolactin signaling pathway_Homo sapiens_hsa04917	0.59190562
70	TNF signaling pathway_Homo sapiens_hsa04668	0.57621780
71	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56478153
72	Renal cell carcinoma_Homo sapiens_hsa05211	0.55757604
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.55484708
74	Viral myocarditis_Homo sapiens_hsa05416	0.55377102
75	Melanoma_Homo sapiens_hsa05218	0.55090313
76	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54513177
77	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.52072862
78	Apoptosis_Homo sapiens_hsa04210	0.51835427
79	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51342444
80	Leishmaniasis_Homo sapiens_hsa05140	0.49872277
81	Pathways in cancer_Homo sapiens_hsa05200	0.48936184
82	mTOR signaling pathway_Homo sapiens_hsa04150	0.48462108
83	AMPK signaling pathway_Homo sapiens_hsa04152	0.48170986
84	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47933387
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47828011
86	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.47506726
87	GnRH signaling pathway_Homo sapiens_hsa04912	0.47403637
88	Small cell lung cancer_Homo sapiens_hsa05222	0.45860216
89	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.44674710
90	Influenza A_Homo sapiens_hsa05164	0.43145796
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.42407484
92	Toxoplasmosis_Homo sapiens_hsa05145	0.40735343
93	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.40179938
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.38659340
95	Viral carcinogenesis_Homo sapiens_hsa05203	0.38190304
96	MicroRNAs in cancer_Homo sapiens_hsa05206	0.37905713
97	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.36523302
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.36299811
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.36130031
100	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.35168278

C19ORF43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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