ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	6.75344182
2	behavioral response to nicotine (GO:0035095)	4.61132280
3	acrosome reaction (GO:0007340)	4.41268000
4	sperm motility (GO:0030317)	4.29403660
5	piRNA metabolic process (GO:0034587)	3.96131929
6	tryptophan catabolic process (GO:0006569)	3.88833299
7	indole-containing compound catabolic process (GO:0042436)	3.88833299
8	indolalkylamine catabolic process (GO:0046218)	3.88833299
9	cellular ketone body metabolic process (GO:0046950)	3.85652396
10	indolalkylamine metabolic process (GO:0006586)	3.85499735
11	epithelial cilium movement (GO:0003351)	3.78175690
12	tryptophan metabolic process (GO:0006568)	3.66835030
13	detection of light stimulus involved in sensory perception (GO:0050962)	3.62237852
14	detection of light stimulus involved in visual perception (GO:0050908)	3.62237852
15	regulation of cilium movement (GO:0003352)	3.61123227
16	DNA methylation involved in gamete generation (GO:0043046)	3.58119117
17	single strand break repair (GO:0000012)	3.51922064
18	platelet dense granule organization (GO:0060155)	3.49710027
19	fusion of sperm to egg plasma membrane (GO:0007342)	3.49598756
20	nonmotile primary cilium assembly (GO:0035058)	3.49295612
21	protein polyglutamylation (GO:0018095)	3.46593583
22	ketone body metabolic process (GO:1902224)	3.44685733
23	kynurenine metabolic process (GO:0070189)	3.32542017
24	fucose catabolic process (GO:0019317)	3.29376286
25	L-fucose metabolic process (GO:0042354)	3.29376286
26	L-fucose catabolic process (GO:0042355)	3.29376286
27	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.22306542
28	RNA destabilization (GO:0050779)	3.17402740
29	negative regulation of mast cell activation (GO:0033004)	3.16892513
30	multicellular organism reproduction (GO:0032504)	3.15506082
31	spermatid development (GO:0007286)	3.14499558
32	behavioral response to ethanol (GO:0048149)	3.14095676
33	gamma-aminobutyric acid transport (GO:0015812)	3.13604492
34	axoneme assembly (GO:0035082)	3.12486569
35	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07649698
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.05986706
37	cilium movement (GO:0003341)	3.04292140
38	protein localization to cilium (GO:0061512)	3.04084307
39	pyrimidine nucleobase catabolic process (GO:0006208)	3.03577140
40	centriole replication (GO:0007099)	3.02776573
41	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.02601219
42	cellular biogenic amine catabolic process (GO:0042402)	3.01928518
43	amine catabolic process (GO:0009310)	3.01928518
44	cilium or flagellum-dependent cell motility (GO:0001539)	3.00020965
45	cell wall macromolecule metabolic process (GO:0044036)	2.99721972
46	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.98852798
47	positive regulation of mitochondrial fission (GO:0090141)	2.98295105
48	protein-cofactor linkage (GO:0018065)	2.91067202
49	photoreceptor cell maintenance (GO:0045494)	2.91012022
50	phosphatidylethanolamine metabolic process (GO:0046337)	2.90968629
51	regulation of action potential (GO:0098900)	2.90687018
52	cornea development in camera-type eye (GO:0061303)	2.89980884
53	preassembly of GPI anchor in ER membrane (GO:0016254)	2.89258313
54	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.89199186
55	cilium morphogenesis (GO:0060271)	2.86281847
56	regulation of microtubule-based movement (GO:0060632)	2.83676377
57	plasma membrane fusion (GO:0045026)	2.82086323
58	adaptation of signaling pathway (GO:0023058)	2.81352193
59	indole-containing compound metabolic process (GO:0042430)	2.80933819
60	cilium organization (GO:0044782)	2.80772899
61	cell wall macromolecule catabolic process (GO:0016998)	2.79603050
62	protein K11-linked deubiquitination (GO:0035871)	2.78082987
63	cilium assembly (GO:0042384)	2.77429528
64	sperm-egg recognition (GO:0035036)	2.72548978
65	establishment of protein localization to Golgi (GO:0072600)	2.71443027
66	intraciliary transport (GO:0042073)	2.68982977
67	male meiosis (GO:0007140)	2.68698730
68	nucleobase catabolic process (GO:0046113)	2.68629191
69	calcium ion-dependent exocytosis (GO:0017156)	2.68133696
70	tachykinin receptor signaling pathway (GO:0007217)	2.67781846
71	male meiosis I (GO:0007141)	2.67468345
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66134808
73	axonemal dynein complex assembly (GO:0070286)	2.65973472
74	photoreceptor cell development (GO:0042461)	2.65662069
75	regulation of meiosis I (GO:0060631)	2.64052879
76	positive regulation of action potential (GO:0045760)	2.62798682
77	neural tube formation (GO:0001841)	2.59598545
78	regulation of collateral sprouting (GO:0048670)	2.59276728
79	neuronal action potential (GO:0019228)	2.58649209
80	histone H3-K9 methylation (GO:0051567)	2.58098643
81	protein targeting to Golgi (GO:0000042)	2.57511098
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.56422530
83	ubiquinone biosynthetic process (GO:0006744)	2.56410272
84	synaptic transmission, cholinergic (GO:0007271)	2.56027111
85	cAMP catabolic process (GO:0006198)	2.53021718
86	rhodopsin mediated signaling pathway (GO:0016056)	2.52337909
87	ubiquinone metabolic process (GO:0006743)	2.51731519
88	transmission of nerve impulse (GO:0019226)	2.51425896
89	retinal cone cell development (GO:0046549)	2.50039182
90	somite development (GO:0061053)	2.47257408
91	eye photoreceptor cell development (GO:0042462)	2.45458714
92	protein localization to Golgi apparatus (GO:0034067)	2.45287498
93	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.45182929
94	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.45182929
95	recombinational repair (GO:0000725)	2.45023967
96	double-strand break repair via homologous recombination (GO:0000724)	2.43633033
97	aromatic amino acid family catabolic process (GO:0009074)	2.43409275
98	postsynaptic membrane organization (GO:0001941)	2.41746743
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.40499748
100	NADH dehydrogenase complex assembly (GO:0010257)	2.40499748

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.11023260
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.34787660
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.96796310
4	VDR_22108803_ChIP-Seq_LS180_Human	2.80052128
5	FUS_26573619_Chip-Seq_HEK293_Human	2.67838974
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.67363260
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57911817
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.54367636
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.46934191
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.40779354
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.30829096
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19657401
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.18150988
14	EWS_26573619_Chip-Seq_HEK293_Human	2.17358002
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.12889079
16	P300_19829295_ChIP-Seq_ESCs_Human	2.12417430
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.05276966
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.03850007
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.98619964
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.79874435
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76776717
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.76111559
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.76111559
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.67848732
25	AR_25329375_ChIP-Seq_VCAP_Human	1.67234404
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.66635975
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.66317839
28	AR_21572438_ChIP-Seq_LNCaP_Human	1.58305152
29	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56667375
30	REST_21632747_ChIP-Seq_MESCs_Mouse	1.54014874
31	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51314450
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51076039
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50014705
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.48649438
35	STAT3_23295773_ChIP-Seq_U87_Human	1.46154567
36	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.46103075
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.46026204
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.45492298
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.45030803
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44605693
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43913269
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42510229
43	RUNX2_22187159_ChIP-Seq_PCA_Human	1.42217509
44	SOX2_19829295_ChIP-Seq_ESCs_Human	1.41621001
45	NANOG_19829295_ChIP-Seq_ESCs_Human	1.41621001
46	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.37896788
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37624162
48	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.37033187
49	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36122792
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36122792
51	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.35813163
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35345661
53	TCF4_23295773_ChIP-Seq_U87_Human	1.34480080
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33676476
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33676476
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.31246933
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.28254817
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.26914306
59	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.26260319
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.26224373
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25139449
62	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22454223
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.21707199
64	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.21608312
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.21341986
66	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20431765
67	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19778478
68	* NCOR_22424771_ChIP-Seq_293T_Human	1.19587577
69	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.18700006
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17953239
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.16854735
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.16635885
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.14701988
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.14382962
75	AR_20517297_ChIP-Seq_VCAP_Human	1.12996514
76	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10225583
77	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10020006
78	ERA_21632823_ChIP-Seq_H3396_Human	1.08894502
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08749391
80	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.06189332
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05433005
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.02902461
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02492876
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01361463
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00982114
86	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.99783688
87	MYC_18940864_ChIP-ChIP_HL60_Human	0.99275800
88	SMRT_27268052_Chip-Seq_Bcells_Human	0.98697317
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98339297
90	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97387350
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97197888
92	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.96723675
93	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.96443134
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.96028202
95	OCT4_20526341_ChIP-Seq_ESCs_Human	0.95423919
96	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.95220846
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94624460
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93775307
99	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92209948
100	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92170384

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.81941849
2	MP0005410_abnormal_fertilization	3.05860688
3	MP0001968_abnormal_touch/_nociception	3.00602119
4	MP0002736_abnormal_nociception_after	2.79109250
5	MP0003787_abnormal_imprinting	2.62461298
6	MP0005646_abnormal_pituitary_gland	2.38999443
7	MP0003011_delayed_dark_adaptation	2.38386097
8	MP0001986_abnormal_taste_sensitivity	2.24472717
9	MP0005551_abnormal_eye_electrophysiolog	2.23547182
10	MP0000372_irregular_coat_pigmentation	2.21637923
11	MP0006292_abnormal_olfactory_placode	2.14613519
12	MP0008872_abnormal_physiological_respon	2.10682432
13	MP0006276_abnormal_autonomic_nervous	1.93017082
14	MP0003880_abnormal_central_pattern	1.92623351
15	MP0002102_abnormal_ear_morphology	1.89992306
16	MP0002638_abnormal_pupillary_reflex	1.88921628
17	MP0005645_abnormal_hypothalamus_physiol	1.87100542
18	MP0002653_abnormal_ependyma_morphology	1.84549786
19	MP0009046_muscle_twitch	1.83528330
20	MP0009745_abnormal_behavioral_response	1.78400058
21	MP0002272_abnormal_nervous_system	1.73773025
22	MP0005423_abnormal_somatic_nervous	1.69679947
23	MP0002234_abnormal_pharynx_morphology	1.69186410
24	MP0001486_abnormal_startle_reflex	1.69039051
25	MP0005253_abnormal_eye_physiology	1.67826200
26	MP0003698_abnormal_male_reproductive	1.67816901
27	MP0002928_abnormal_bile_duct	1.66502880
28	MP0003195_calcinosis	1.61174907
29	MP0008995_early_reproductive_senescence	1.58958972
30	MP0004133_heterotaxia	1.58665147
31	MP0008875_abnormal_xenobiotic_pharmacok	1.58384358
32	MP0001501_abnormal_sleep_pattern	1.56177868
33	MP0005084_abnormal_gallbladder_morpholo	1.55789043
34	MP0002735_abnormal_chemical_nociception	1.54729324
35	MP0001984_abnormal_olfaction	1.49108992
36	MP0005171_absent_coat_pigmentation	1.47592816
37	MP0001929_abnormal_gametogenesis	1.46952334
38	MP0002160_abnormal_reproductive_system	1.45285868
39	MP0001502_abnormal_circadian_rhythm	1.40295080
40	MP0002572_abnormal_emotion/affect_behav	1.40004622
41	MP0003136_yellow_coat_color	1.39502065
42	MP0006072_abnormal_retinal_apoptosis	1.34298578
43	MP0002837_dystrophic_cardiac_calcinosis	1.33502433
44	MP0001764_abnormal_homeostasis	1.32274910
45	MP0004885_abnormal_endolymph	1.31402145
46	MP0000631_abnormal_neuroendocrine_gland	1.26501386
47	MP0002557_abnormal_social/conspecific_i	1.24049041
48	MP0003121_genomic_imprinting	1.23425866
49	MP0002733_abnormal_thermal_nociception	1.22917239
50	MP0003635_abnormal_synaptic_transmissio	1.22497955
51	MP0001905_abnormal_dopamine_level	1.20000300
52	MP0001970_abnormal_pain_threshold	1.19876781
53	MP0005389_reproductive_system_phenotype	1.18731810
54	MP0005670_abnormal_white_adipose	1.18579574
55	MP0002064_seizures	1.18263357
56	MP0008789_abnormal_olfactory_epithelium	1.16622138
57	MP0002067_abnormal_sensory_capabilities	1.16611103
58	MP0000569_abnormal_digit_pigmentation	1.15510268
59	MP0002822_catalepsy	1.13178345
60	MP0002210_abnormal_sex_determination	1.12670128
61	MP0004043_abnormal_pH_regulation	1.10750379
62	MP0002938_white_spotting	1.10106645
63	MP0004142_abnormal_muscle_tone	1.10074903
64	MP0003283_abnormal_digestive_organ	1.09805807
65	MP0002063_abnormal_learning/memory/cond	1.06843621
66	MP0003122_maternal_imprinting	1.05570976
67	MP0005174_abnormal_tail_pigmentation	1.05388333
68	MP0001919_abnormal_reproductive_system	1.03051372
69	MP0003718_maternal_effect	1.02485395
70	MP0001485_abnormal_pinna_reflex	1.02105974
71	MP0000026_abnormal_inner_ear	1.02060192
72	MP0008058_abnormal_DNA_repair	1.01128653
73	MP0002132_abnormal_respiratory_system	0.98664381
74	MP0000653_abnormal_sex_gland	0.96797339
75	MP0000778_abnormal_nervous_system	0.96398816
76	MP0002876_abnormal_thyroid_physiology	0.95941761
77	MP0005499_abnormal_olfactory_system	0.95603293
78	MP0005394_taste/olfaction_phenotype	0.95603293
79	MP0005379_endocrine/exocrine_gland_phen	0.93291062
80	MP0002229_neurodegeneration	0.93285038
81	MP0003119_abnormal_digestive_system	0.91296244
82	MP0004147_increased_porphyrin_level	0.90812889
83	MP0005195_abnormal_posterior_eye	0.90027375
84	MP0001145_abnormal_male_reproductive	0.89861644
85	MP0002752_abnormal_somatic_nervous	0.88940595
86	MP0004742_abnormal_vestibular_system	0.88623202
87	MP0002163_abnormal_gland_morphology	0.87287997
88	MP0001963_abnormal_hearing_physiology	0.86686769
89	MP0001529_abnormal_vocalization	0.84505427
90	MP0002734_abnormal_mechanical_nocicepti	0.83987773
91	MP0003646_muscle_fatigue	0.83766528
92	MP0000955_abnormal_spinal_cord	0.83125679
93	MP0001324_abnormal_eye_pigmentation	0.81134212
94	MP0002184_abnormal_innervation	0.80531913
95	MP0010386_abnormal_urinary_bladder	0.80447523
96	MP0005367_renal/urinary_system_phenotyp	0.79980750
97	MP0000516_abnormal_urinary_system	0.79980750
98	MP0004859_abnormal_synaptic_plasticity	0.78493048
99	MP0005377_hearing/vestibular/ear_phenot	0.78376890
100	MP0003878_abnormal_ear_physiology	0.78376890

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.25979401
2	True hermaphroditism (HP:0010459)	3.91572257
3	Pancreatic fibrosis (HP:0100732)	3.75537871
4	Congenital stationary night blindness (HP:0007642)	3.73787295
5	Type II lissencephaly (HP:0007260)	3.70421696
6	Nephronophthisis (HP:0000090)	3.63794261
7	Abnormality of midbrain morphology (HP:0002418)	3.53802736
8	Molar tooth sign on MRI (HP:0002419)	3.53802736
9	Attenuation of retinal blood vessels (HP:0007843)	3.38230144
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.36093650
11	Abnormality of the renal medulla (HP:0100957)	3.17377867
12	Medial flaring of the eyebrow (HP:0010747)	3.09159566
13	Polydipsia (HP:0001959)	3.02237973
14	Abnormal drinking behavior (HP:0030082)	3.02237973
15	Chronic hepatic failure (HP:0100626)	2.98282395
16	Cystic liver disease (HP:0006706)	2.93189396
17	Retinal dysplasia (HP:0007973)	2.87290275
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.81257287
19	Abnormality of the renal cortex (HP:0011035)	2.74493244
20	Febrile seizures (HP:0002373)	2.72814728
21	Gait imbalance (HP:0002141)	2.69606833
22	Decreased central vision (HP:0007663)	2.68292785
23	Bony spicule pigmentary retinopathy (HP:0007737)	2.62233159
24	Cerebellar dysplasia (HP:0007033)	2.61829344
25	Congenital primary aphakia (HP:0007707)	2.61739011
26	Sclerocornea (HP:0000647)	2.54998192
27	Pendular nystagmus (HP:0012043)	2.53854792
28	Polyuria (HP:0000103)	2.52078240
29	Nephrogenic diabetes insipidus (HP:0009806)	2.49204932
30	Anencephaly (HP:0002323)	2.39402869
31	Abnormal biliary tract physiology (HP:0012439)	2.35734729
32	Bile duct proliferation (HP:0001408)	2.35734729
33	Abnormality of the labia minora (HP:0012880)	2.34501890
34	Stomach cancer (HP:0012126)	2.34465317
35	Abolished electroretinogram (ERG) (HP:0000550)	2.34112579
36	Tubular atrophy (HP:0000092)	2.33947510
37	Focal motor seizures (HP:0011153)	2.33322128
38	Progressive cerebellar ataxia (HP:0002073)	2.28408096
39	Lissencephaly (HP:0001339)	2.28328256
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.27654633
41	Hypomagnesemia (HP:0002917)	2.18852606
42	Hyperventilation (HP:0002883)	2.17724391
43	Postaxial foot polydactyly (HP:0001830)	2.14309618
44	Tetany (HP:0001281)	2.13325516
45	Abnormal urine output (HP:0012590)	2.10665366
46	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09582656
47	Absent/shortened dynein arms (HP:0200106)	2.09582656
48	Genital tract atresia (HP:0001827)	2.07519211
49	Vaginal atresia (HP:0000148)	2.05818425
50	Tubulointerstitial nephritis (HP:0001970)	2.02155784
51	Acute necrotizing encephalopathy (HP:0006965)	2.02020287
52	Severe visual impairment (HP:0001141)	2.01924931
53	Poor coordination (HP:0002370)	2.01006000
54	Mitochondrial inheritance (HP:0001427)	1.98865810
55	Inability to walk (HP:0002540)	1.98376580
56	Congenital hepatic fibrosis (HP:0002612)	1.96130493
57	Abnormality of B cell number (HP:0010975)	1.94920750
58	Renal cortical cysts (HP:0000803)	1.94464432
59	Hemiparesis (HP:0001269)	1.93454892
60	Male pseudohermaphroditism (HP:0000037)	1.91275765
61	Decreased circulating renin level (HP:0003351)	1.90521626
62	Congenital sensorineural hearing impairment (HP:0008527)	1.88062452
63	Epileptic encephalopathy (HP:0200134)	1.86888072
64	Optic nerve hypoplasia (HP:0000609)	1.86205711
65	Acute encephalopathy (HP:0006846)	1.84965899
66	Progressive macrocephaly (HP:0004481)	1.84403978
67	Large for gestational age (HP:0001520)	1.84081302
68	Increased CSF lactate (HP:0002490)	1.83695308
69	Postaxial hand polydactyly (HP:0001162)	1.81982243
70	Aplasia/Hypoplasia of the patella (HP:0006498)	1.81670441
71	Thyroiditis (HP:0100646)	1.81644866
72	Keratoconus (HP:0000563)	1.80665979
73	Increased corneal curvature (HP:0100692)	1.80665979
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80275213
75	Abnormal respiratory epithelium morphology (HP:0012253)	1.80275213
76	Abnormality of the renal collecting system (HP:0004742)	1.80182913
77	Intestinal atresia (HP:0011100)	1.80074524
78	Gaze-evoked nystagmus (HP:0000640)	1.79854198
79	Tubulointerstitial abnormality (HP:0001969)	1.79723957
80	Broad-based gait (HP:0002136)	1.77491522
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77333611
82	Abnormality of dental color (HP:0011073)	1.76865388
83	Abnormality of renal excretion (HP:0011036)	1.76678741
84	Optic disc pallor (HP:0000543)	1.76625467
85	Astigmatism (HP:0000483)	1.74663712
86	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.74406046
87	Abnormal mitochondria in muscle tissue (HP:0008316)	1.73666569
88	Severe muscular hypotonia (HP:0006829)	1.73189177
89	Patellar aplasia (HP:0006443)	1.73132234
90	Aganglionic megacolon (HP:0002251)	1.72101968
91	Absent speech (HP:0001344)	1.70753338
92	Hyperglycinemia (HP:0002154)	1.69642241
93	Small hand (HP:0200055)	1.68643854
94	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.68524862
95	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68387205
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.67996972
97	Retinitis pigmentosa (HP:0000510)	1.65614308
98	Hypothermia (HP:0002045)	1.64852193
99	Focal seizures (HP:0007359)	1.64311434
100	Occipital encephalocele (HP:0002085)	1.64228961

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.28138819
2	PINK1	3.42620615
3	MAP4K2	3.39856864
4	ADRBK2	3.21282134
5	WNK3	2.83955884
6	TAOK3	2.30548214
7	PDK2	2.27496428
8	MAPK13	2.16411013
9	BMPR1B	2.14464446
10	GRK1	2.06180656
11	INSRR	1.99868442
12	ZAK	1.98273851
13	TRIM28	1.96646606
14	WNK4	1.88880987
15	MAPK15	1.88855714
16	NUAK1	1.88226885
17	STK16	1.84264709
18	ACVR1B	1.70883075
19	MAP3K4	1.70624290
20	BCKDK	1.67931614
21	PLK2	1.66301309
22	PLK4	1.62307217
23	MAP2K7	1.55040390
24	STK38L	1.53810816
25	STK39	1.51726050
26	PNCK	1.39535917
27	DYRK2	1.38952342
28	ERBB3	1.37360114
29	MARK1	1.26401814
30	TNIK	1.13331578
31	ADRBK1	1.13051929
32	CASK	1.09107806
33	SIK2	1.08818323
34	NTRK3	1.06302209
35	OXSR1	1.03991526
36	TLK1	1.03699958
37	DAPK2	1.01406791
38	BRSK2	0.99311794
39	PRKCG	0.98791368
40	TIE1	0.96945488
41	PAK3	0.96780550
42	PRKCE	0.93805428
43	CAMKK2	0.92648726
44	MKNK2	0.89146182
45	DYRK1A	0.87947485
46	FGFR2	0.87602018
47	PRKD3	0.87246913
48	AKT3	0.86865632
49	CSNK1G3	0.84026779
50	CSNK1G2	0.80794496
51	CSNK1G1	0.78906816
52	VRK1	0.77779852
53	DYRK3	0.76427497
54	TAF1	0.71321050
55	PASK	0.69458399
56	NTRK2	0.69282280
57	CSNK1A1L	0.67765126
58	FLT3	0.66169672
59	PKN1	0.66000787
60	BCR	0.63139466
61	CAMK1	0.62368263
62	GRK5	0.62013609
63	STK38	0.61190542
64	PRKCZ	0.60589317
65	SRPK1	0.60069981
66	TXK	0.59706039
67	GRK7	0.58404906
68	MUSK	0.57412529
69	VRK2	0.56689185
70	EPHA4	0.55256055
71	CSNK1A1	0.53822189
72	PIK3CG	0.53303145
73	EPHA3	0.52962233
74	MAPKAPK5	0.51354924
75	MKNK1	0.50059891
76	WEE1	0.48914444
77	NME1	0.48878999
78	PRKCI	0.48433901
79	CAMK1G	0.47490664
80	SGK2	0.46447056
81	IRAK1	0.43495791
82	PTK2B	0.42758926
83	RPS6KA5	0.42680436
84	PLK3	0.42432900
85	PRKACA	0.41181794
86	TGFBR1	0.39496966
87	NEK2	0.39113781
88	EIF2AK3	0.39047622
89	SGK223	0.38586613
90	SGK494	0.38586613
91	NEK6	0.38583023
92	CAMK4	0.38521907
93	CAMK2A	0.37519839
94	CHUK	0.37205464
95	PHKG1	0.36849274
96	PHKG2	0.36849274
97	MINK1	0.35483774
98	PRKAA1	0.35434823
99	MAPKAPK3	0.35420757
100	IKBKB	0.34938725

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.26033168
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.11154444
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.88971341
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.60664106
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.52862287
6	Butanoate metabolism_Homo sapiens_hsa00650	2.52011171
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.32286634
8	Nicotine addiction_Homo sapiens_hsa05033	2.28277644
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15428566
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.11479175
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.10404878
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.06043351
13	Nitrogen metabolism_Homo sapiens_hsa00910	2.02245949
14	Taste transduction_Homo sapiens_hsa04742	1.99223176
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.97681095
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.89708380
17	Olfactory transduction_Homo sapiens_hsa04740	1.86604838
18	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85094984
19	Homologous recombination_Homo sapiens_hsa03440	1.78360142
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.76461538
21	Morphine addiction_Homo sapiens_hsa05032	1.71744166
22	Protein export_Homo sapiens_hsa03060	1.69937864
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.59156038
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.55309659
25	Propanoate metabolism_Homo sapiens_hsa00640	1.54206072
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.50605706
27	Basal transcription factors_Homo sapiens_hsa03022	1.46371317
28	Caffeine metabolism_Homo sapiens_hsa00232	1.45722405
29	RNA polymerase_Homo sapiens_hsa03020	1.39267652
30	Parkinsons disease_Homo sapiens_hsa05012	1.34096613
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.32913000
32	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.26335946
33	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23693541
34	Regulation of autophagy_Homo sapiens_hsa04140	1.22762018
35	Glutamatergic synapse_Homo sapiens_hsa04724	1.21181559
36	RNA degradation_Homo sapiens_hsa03018	1.20968144
37	Circadian entrainment_Homo sapiens_hsa04713	1.19418345
38	Peroxisome_Homo sapiens_hsa04146	1.19029096
39	GABAergic synapse_Homo sapiens_hsa04727	1.16839452
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.11287029
41	Retinol metabolism_Homo sapiens_hsa00830	1.09789692
42	ABC transporters_Homo sapiens_hsa02010	1.09006879
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.08205217
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.07987874
45	Huntingtons disease_Homo sapiens_hsa05016	1.07905066
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06318973
47	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.05406017
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.98187018
49	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98127478
50	Insulin secretion_Homo sapiens_hsa04911	0.97763193
51	Serotonergic synapse_Homo sapiens_hsa04726	0.95406968
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94524451
53	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.93627900
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.90608493
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87859790
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87803875
57	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.87068719
58	Salivary secretion_Homo sapiens_hsa04970	0.84641962
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83550654
60	Alzheimers disease_Homo sapiens_hsa05010	0.82098990
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.77991310
62	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76259315
63	Purine metabolism_Homo sapiens_hsa00230	0.75779082
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.69266198
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.68493283
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.68268661
67	Metabolic pathways_Homo sapiens_hsa01100	0.68179353
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67640822
69	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.66932777
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.66879824
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.66564952
72	One carbon pool by folate_Homo sapiens_hsa00670	0.66385878
73	Primary immunodeficiency_Homo sapiens_hsa05340	0.66189045
74	Circadian rhythm_Homo sapiens_hsa04710	0.65991749
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65722001
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.64732513
77	Dopaminergic synapse_Homo sapiens_hsa04728	0.63434077
78	Cocaine addiction_Homo sapiens_hsa05030	0.62397934
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.60595518
80	Amphetamine addiction_Homo sapiens_hsa05031	0.55816155
81	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.53432118
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.52513721
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51818830
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.50525775
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45894191
86	Lysine degradation_Homo sapiens_hsa00310	0.44940562
87	Fatty acid degradation_Homo sapiens_hsa00071	0.43183304
88	Fatty acid elongation_Homo sapiens_hsa00062	0.42073878
89	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.41121727
90	Sulfur relay system_Homo sapiens_hsa04122	0.37809886
91	Cholinergic synapse_Homo sapiens_hsa04725	0.37588322
92	Long-term depression_Homo sapiens_hsa04730	0.37046038
93	RNA transport_Homo sapiens_hsa03013	0.36650460
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.35752919
95	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.35366067
96	cAMP signaling pathway_Homo sapiens_hsa04024	0.32467315
97	Base excision repair_Homo sapiens_hsa03410	0.30789132
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.30621955
99	Type I diabetes mellitus_Homo sapiens_hsa04940	0.30434058
100	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30039359

C19ORF45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »