ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA strand elongation involved in DNA replication (GO:0006271)	4.90205563
2	DNA strand elongation (GO:0022616)	4.73886256
3	DNA unwinding involved in DNA replication (GO:0006268)	4.65435840
4	telomere maintenance via semi-conservative replication (GO:0032201)	4.65190569
5	DNA replication initiation (GO:0006270)	4.36957713
6	translesion synthesis (GO:0019985)	4.35980144
7	DNA replication checkpoint (GO:0000076)	4.26794710
8	mitotic sister chromatid cohesion (GO:0007064)	3.99261664
9	postreplication repair (GO:0006301)	3.94903608
10	telomere maintenance via recombination (GO:0000722)	3.92958945
11	mitotic chromosome condensation (GO:0007076)	3.79273646
12	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.71758396
13	meiotic chromosome segregation (GO:0045132)	3.68746932
14	DNA double-strand break processing (GO:0000729)	3.66000677
15	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.63018139
16	mitotic recombination (GO:0006312)	3.61238796
17	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.56334635
18	DNA synthesis involved in DNA repair (GO:0000731)	3.53520484
19	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.48750267
20	DNA topological change (GO:0006265)	3.42776125
21	sister chromatid cohesion (GO:0007062)	3.37096924
22	histone H2A acetylation (GO:0043968)	3.29699662
23	chromosome organization involved in meiosis (GO:0070192)	3.21308738
24	protein localization to chromosome, centromeric region (GO:0071459)	3.15647883
25	presynaptic membrane assembly (GO:0097105)	3.13442442
26	regulation of sister chromatid cohesion (GO:0007063)	3.13251936
27	protein localization to kinetochore (GO:0034501)	3.11861248
28	postsynaptic membrane organization (GO:0001941)	3.10169837
29	synaptonemal complex assembly (GO:0007130)	3.09454543
30	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.09127070
31	kinetochore organization (GO:0051383)	3.07518161
32	microtubule depolymerization (GO:0007019)	3.05564422
33	telomere maintenance via telomere lengthening (GO:0010833)	3.03953460
34	synapsis (GO:0007129)	3.03438977
35	protein localization to chromosome (GO:0034502)	3.01578637
36	regulation of DNA endoreduplication (GO:0032875)	3.01388646
37	piRNA metabolic process (GO:0034587)	3.00004739
38	histone arginine methylation (GO:0034969)	2.93100724
39	protein K6-linked ubiquitination (GO:0085020)	2.91250121
40	DNA replication-dependent nucleosome organization (GO:0034723)	2.88226274
41	DNA replication-dependent nucleosome assembly (GO:0006335)	2.88226274
42	DNA biosynthetic process (GO:0071897)	2.87794636
43	CENP-A containing nucleosome assembly (GO:0034080)	2.87791240
44	chromatin remodeling at centromere (GO:0031055)	2.87563725
45	mitotic sister chromatid segregation (GO:0000070)	2.86757009
46	protein insertion into membrane (GO:0051205)	2.86186117
47	base-excision repair (GO:0006284)	2.85901228
48	neuron cell-cell adhesion (GO:0007158)	2.84278084
49	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.79230962
50	negative regulation of mRNA processing (GO:0050686)	2.78366583
51	dosage compensation (GO:0007549)	2.74793160
52	protein-DNA complex disassembly (GO:0032986)	2.74313319
53	nucleosome disassembly (GO:0006337)	2.74313319
54	establishment of integrated proviral latency (GO:0075713)	2.73978645
55	synaptonemal complex organization (GO:0070193)	2.73567384
56	establishment of mitochondrion localization (GO:0051654)	2.72605353
57	DNA replication (GO:0006260)	2.72451732
58	pyrimidine nucleobase catabolic process (GO:0006208)	2.72367350
59	DNA methylation involved in gamete generation (GO:0043046)	2.72286843
60	cell migration in hindbrain (GO:0021535)	2.72036953
61	regulation of centriole replication (GO:0046599)	2.71705557
62	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.68961554
63	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.66819611
64	nonmotile primary cilium assembly (GO:0035058)	2.66405846
65	DNA damage response, detection of DNA damage (GO:0042769)	2.65768170
66	mechanosensory behavior (GO:0007638)	2.62047902
67	peptidyl-arginine omega-N-methylation (GO:0035247)	2.61387599
68	auditory behavior (GO:0031223)	2.61368518
69	neurofilament cytoskeleton organization (GO:0060052)	2.60763945
70	resolution of meiotic recombination intermediates (GO:0000712)	2.59196363
71	ATP-dependent chromatin remodeling (GO:0043044)	2.58660409
72	DNA replication-independent nucleosome assembly (GO:0006336)	2.58439347
73	DNA replication-independent nucleosome organization (GO:0034724)	2.58439347
74	kinetochore assembly (GO:0051382)	2.57727450
75	sister chromatid segregation (GO:0000819)	2.57224701
76	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.56091192
77	mRNA splice site selection (GO:0006376)	2.53328475
78	mitochondrial DNA metabolic process (GO:0032042)	2.53003225
79	L-serine metabolic process (GO:0006563)	2.52108205
80	regulation of DNA-dependent DNA replication (GO:0090329)	2.51163929
81	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49854810
82	regulation of meiosis I (GO:0060631)	2.48976893
83	regulation of centrosome cycle (GO:0046605)	2.48811836
84	gamma-aminobutyric acid transport (GO:0015812)	2.48501594
85	fatty acid elongation (GO:0030497)	2.48286427
86	negative regulation of RNA splicing (GO:0033119)	2.47197860
87	mitochondrial DNA replication (GO:0006264)	2.46862891
88	regulation of mitochondrial translation (GO:0070129)	2.43858362
89	mismatch repair (GO:0006298)	2.42465071
90	positive regulation of growth hormone secretion (GO:0060124)	2.41510971
91	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.41436323
92	transcription-coupled nucleotide-excision repair (GO:0006283)	2.40955587
93	spliceosomal snRNP assembly (GO:0000387)	2.40910426
94	meiotic nuclear division (GO:0007126)	2.40550116
95	DNA ligation (GO:0006266)	2.39143554
96	presynaptic membrane organization (GO:0097090)	2.39055595
97	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.38625442
98	histone exchange (GO:0043486)	2.38220387
99	chromosome segregation (GO:0007059)	2.37026154
100	chromatin assembly or disassembly (GO:0006333)	2.34209645

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.76435990
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.48187083
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.11569471
4	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.00429358
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.84133496
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.76106706
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.61947714
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.61711596
9	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.57622452
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.36914496
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.28667671
12	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.25845227
13	* E2F1_21310950_ChIP-Seq_MCF-7_Human	2.21955589
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.21514975
15	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.16626617
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.16578565
17	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	2.13489277
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.13017501
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.11883355
20	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.11526254
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.09087216
22	TTF2_22483619_ChIP-Seq_HELA_Human	2.02382957
23	E2F7_22180533_ChIP-Seq_HELA_Human	10.3251756
24	* GABP_19822575_ChIP-Seq_HepG2_Human	1.99447852
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99381101
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.95404664
27	DCP1A_22483619_ChIP-Seq_HELA_Human	1.93326263
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89069249
29	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.85898410
30	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.85603402
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.81446479
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.79172711
33	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.76506055
34	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.71908894
35	KDM5A_27292631_Chip-Seq_BREAST_Human	1.63847158
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.63574886
37	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.63380484
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60200996
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.59957122
40	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57454530
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57100149
42	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.51901962
43	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.51002044
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45931625
45	AR_21909140_ChIP-Seq_LNCAP_Human	1.45353574
46	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.45312316
47	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.45206327
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.43433738
49	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.41093905
50	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.40440435
51	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.40195833
52	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.37751652
53	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.36128431
54	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.30511827
55	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.25204959
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.24576697
57	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.23606059
58	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.23081336
59	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.22505202
60	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.20678335
61	VDR_23849224_ChIP-Seq_CD4+_Human	1.17985849
62	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.14646340
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.12246226
64	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.11312994
65	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08576376
66	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.08308211
67	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.08001501
68	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07855541
69	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.07501521
70	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02373992
71	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.00129356
72	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.97702473
73	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.97578700
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97102917
75	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.96472892
76	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.93636405
77	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93132906
78	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.92155582
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91452893
80	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.91285872
81	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.91111423
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90590025
83	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.89273566
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.87591281
85	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.85734955
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.85274010
87	ELK1_19687146_ChIP-ChIP_HELA_Human	0.84605573
88	* FOXP1_21924763_ChIP-Seq_HESCs_Human	0.83811914
89	P68_20966046_ChIP-Seq_HELA_Human	0.83602615
90	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.82271697
91	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82175675
92	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.79267403
93	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.78215327
94	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.75045927
95	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.74364109
96	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.73628026
97	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.72434723
98	MYC_22102868_ChIP-Seq_BL_Human	0.71873381
99	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.71723122
100	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.71403894

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	3.70656095
2	MP0001529_abnormal_vocalization	2.88400235
3	MP0003111_abnormal_nucleus_morphology	2.85944882
4	MP0008058_abnormal_DNA_repair	2.71681471
5	MP0001188_hyperpigmentation	2.66562713
6	MP0002822_catalepsy	2.60239232
7	MP0008057_abnormal_DNA_replication	2.46968537
8	MP0003693_abnormal_embryo_hatching	2.41504050
9	MP0003077_abnormal_cell_cycle	2.17400260
10	MP0003880_abnormal_central_pattern	2.00574938
11	MP0008932_abnormal_embryonic_tissue	1.93963629
12	MP0005394_taste/olfaction_phenotype	1.83780222
13	MP0005499_abnormal_olfactory_system	1.83780222
14	MP0002210_abnormal_sex_determination	1.81529144
15	MP0008789_abnormal_olfactory_epithelium	1.78585034
16	MP0003283_abnormal_digestive_organ	1.68788349
17	MP0006292_abnormal_olfactory_placode	1.68402428
18	MP0000537_abnormal_urethra_morphology	1.67121323
19	MP0000566_synostosis	1.61562674
20	MP0008995_early_reproductive_senescence	1.60442809
21	MP0005646_abnormal_pituitary_gland	1.59385882
22	MP0004957_abnormal_blastocyst_morpholog	1.57591827
23	MP0002234_abnormal_pharynx_morphology	1.51014398
24	MP0008877_abnormal_DNA_methylation	1.50881204
25	MP0001346_abnormal_lacrimal_gland	1.49172136
26	MP0000631_abnormal_neuroendocrine_gland	1.48962940
27	MP0003119_abnormal_digestive_system	1.48009564
28	MP0004859_abnormal_synaptic_plasticity	1.47674269
29	MP0000049_abnormal_middle_ear	1.44041926
30	MP0001929_abnormal_gametogenesis	1.41243037
31	MP0002735_abnormal_chemical_nociception	1.39997749
32	MP0002249_abnormal_larynx_morphology	1.39428769
33	MP0003718_maternal_effect	1.38526139
34	MP0005423_abnormal_somatic_nervous	1.33971188
35	MP0000778_abnormal_nervous_system	1.32895977
36	MP0001145_abnormal_male_reproductive	1.32757364
37	MP0003861_abnormal_nervous_system	1.31063464
38	MP0004147_increased_porphyrin_level	1.30753261
39	MP0006276_abnormal_autonomic_nervous	1.29913001
40	MP0001984_abnormal_olfaction	1.28697682
41	MP0010307_abnormal_tumor_latency	1.23874751
42	MP0001730_embryonic_growth_arrest	1.23676427
43	MP0010030_abnormal_orbit_morphology	1.23472957
44	MP0000653_abnormal_sex_gland	1.23142356
45	MP0008260_abnormal_autophagy	1.20477564
46	MP0003635_abnormal_synaptic_transmissio	1.19751860
47	MP0008007_abnormal_cellular_replicative	1.13607630
48	MP0003698_abnormal_male_reproductive	1.13046196
49	MP0006035_abnormal_mitochondrial_morpho	1.11779620
50	MP0003385_abnormal_body_wall	1.10905409
51	MP0003937_abnormal_limbs/digits/tail_de	1.08203388
52	MP0000350_abnormal_cell_proliferation	1.08120402
53	MP0003890_abnormal_embryonic-extraembry	1.07166823
54	MP0001486_abnormal_startle_reflex	1.05525500
55	MP0002736_abnormal_nociception_after	1.04542249
56	MP0002751_abnormal_autonomic_nervous	1.04431941
57	MP0004197_abnormal_fetal_growth/weight/	1.03827029
58	MP0004811_abnormal_neuron_physiology	1.01500220
59	MP0000678_abnormal_parathyroid_gland	1.01307117
60	MP0002085_abnormal_embryonic_tissue	1.00938542
61	MP0000462_abnormal_digestive_system	1.00650835
62	MP0000955_abnormal_spinal_cord	0.99270148
63	MP0002557_abnormal_social/conspecific_i	0.99099441
64	MP0003121_genomic_imprinting	0.98236026
65	MP0002111_abnormal_tail_morphology	0.98026566
66	MP0002152_abnormal_brain_morphology	0.97574303
67	MP0002909_abnormal_adrenal_gland	0.97262378
68	MP0003786_premature_aging	0.97026815
69	MP0000751_myopathy	0.96301079
70	MP0003136_yellow_coat_color	0.95630756
71	MP0002882_abnormal_neuron_morphology	0.94909699
72	MP0002063_abnormal_learning/memory/cond	0.93771748
73	MP0003938_abnormal_ear_development	0.93745967
74	MP0002161_abnormal_fertility/fecundity	0.93657339
75	MP0003755_abnormal_palate_morphology	0.92529551
76	MP0002653_abnormal_ependyma_morphology	0.91865497
77	MP0002572_abnormal_emotion/affect_behav	0.91851034
78	MP0009046_muscle_twitch	0.91088262
79	MP0001672_abnormal_embryogenesis/_devel	0.90876522
80	MP0005380_embryogenesis_phenotype	0.90876522
81	MP0002160_abnormal_reproductive_system	0.89392006
82	MP0005367_renal/urinary_system_phenotyp	0.89256704
83	MP0000516_abnormal_urinary_system	0.89256704
84	MP0009672_abnormal_birth_weight	0.89202494
85	MP0002084_abnormal_developmental_patter	0.88937928
86	MP0001697_abnormal_embryo_size	0.88345484
87	MP0002272_abnormal_nervous_system	0.86110744
88	MP0002697_abnormal_eye_size	0.86102237
89	MP0003315_abnormal_perineum_morphology	0.85324240
90	MP0002080_prenatal_lethality	0.84964249
91	MP0003935_abnormal_craniofacial_develop	0.82841550
92	MP0001968_abnormal_touch/_nociception	0.82597503
93	MP0000534_abnormal_ureter_morphology	0.82373081
94	MP0002734_abnormal_mechanical_nocicepti	0.82198982
95	MP0000358_abnormal_cell_content/	0.82063207
96	MP0002098_abnormal_vibrissa_morphology	0.81655500
97	MP0004270_analgesia	0.81467193
98	MP0000026_abnormal_inner_ear	0.81161016
99	MP0002184_abnormal_innervation	0.80577517
100	MP0003699_abnormal_female_reproductive	0.80404251

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.97346573
2	Chromsome breakage (HP:0040012)	3.55730363
3	Volvulus (HP:0002580)	3.22456230
4	Cortical dysplasia (HP:0002539)	3.17110593
5	Retinal dysplasia (HP:0007973)	3.12067637
6	Birth length less than 3rd percentile (HP:0003561)	2.99785063
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.98319176
8	Meckel diverticulum (HP:0002245)	2.87718473
9	Abnormality of the ileum (HP:0001549)	2.83376812
10	Abnormality of the preputium (HP:0100587)	2.72786777
11	Increased nuchal translucency (HP:0010880)	2.69785257
12	Patellar aplasia (HP:0006443)	2.50330465
13	Facial hemangioma (HP:0000329)	2.49513958
14	Shoulder girdle muscle weakness (HP:0003547)	2.49363416
15	Morphological abnormality of the inner ear (HP:0011390)	2.46118660
16	Ectopic kidney (HP:0000086)	2.39470324
17	Abnormality of chromosome stability (HP:0003220)	2.38620529
18	Oligodactyly (hands) (HP:0001180)	2.38262472
19	Abnormality of the labia minora (HP:0012880)	2.38107018
20	Abnormality of the carotid arteries (HP:0005344)	2.35054299
21	Aplasia/Hypoplasia of the patella (HP:0006498)	2.29008472
22	Gait imbalance (HP:0002141)	2.24391727
23	Oligodactyly (HP:0012165)	2.20829455
24	Cholecystitis (HP:0001082)	2.16307895
25	Abnormal gallbladder physiology (HP:0012438)	2.16307895
26	Duodenal stenosis (HP:0100867)	2.15876699
27	Small intestinal stenosis (HP:0012848)	2.15876699
28	Abnormality of the lower motor neuron (HP:0002366)	2.14285210
29	Abnormality of cochlea (HP:0000375)	2.04571648
30	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.04318439
31	Congenital primary aphakia (HP:0007707)	2.03866135
32	Obsessive-compulsive behavior (HP:0000722)	2.02862216
33	Aplasia involving forearm bones (HP:0009822)	2.01113009
34	Absent forearm bone (HP:0003953)	2.01113009
35	Delayed myelination (HP:0012448)	2.00472766
36	Heterotopia (HP:0002282)	1.98724836
37	Absent radius (HP:0003974)	1.98239766
38	Duplicated collecting system (HP:0000081)	1.97723903
39	Nephrogenic diabetes insipidus (HP:0009806)	1.97654427
40	Ulnar claw (HP:0001178)	1.96343185
41	Triphalangeal thumb (HP:0001199)	1.95154908
42	Abnormality of the duodenum (HP:0002246)	1.93271535
43	Impulsivity (HP:0100710)	1.92936881
44	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.92076101
45	Hypoplasia of the brainstem (HP:0002365)	1.92076101
46	Broad alveolar ridges (HP:0000187)	1.91277601
47	Microvesicular hepatic steatosis (HP:0001414)	1.88927558
48	Gonadotropin excess (HP:0000837)	1.88190962
49	Lissencephaly (HP:0001339)	1.84103615
50	Clubbing of toes (HP:0100760)	1.84093740
51	Microglossia (HP:0000171)	1.82884609
52	Medial flaring of the eyebrow (HP:0010747)	1.81237335
53	Urethral obstruction (HP:0000796)	1.79433949
54	Progressive microcephaly (HP:0000253)	1.78230304
55	Medulloblastoma (HP:0002885)	1.78015109
56	Pachygyria (HP:0001302)	1.76863047
57	Abnormal hair whorl (HP:0010721)	1.76681229
58	Sloping forehead (HP:0000340)	1.75541573
59	Bowel incontinence (HP:0002607)	1.74409968
60	Capillary hemangiomas (HP:0005306)	1.74343411
61	Hammertoe (HP:0001765)	1.72684440
62	High anterior hairline (HP:0009890)	1.71951089
63	Short thumb (HP:0009778)	1.71527750
64	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.71451685
65	Abnormality of homocysteine metabolism (HP:0010919)	1.70480989
66	Homocystinuria (HP:0002156)	1.70480989
67	Gastroesophageal reflux (HP:0002020)	1.69570053
68	Abnormality of the renal collecting system (HP:0004742)	1.69243381
69	Proximal placement of thumb (HP:0009623)	1.68790848
70	Choanal atresia (HP:0000453)	1.68463568
71	Methylmalonic acidemia (HP:0002912)	1.68096079
72	11 pairs of ribs (HP:0000878)	1.67466756
73	Astigmatism (HP:0000483)	1.66428376
74	Hypsarrhythmia (HP:0002521)	1.66194806
75	Postnatal microcephaly (HP:0005484)	1.66119548
76	Split foot (HP:0001839)	1.65531946
77	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.65017435
78	Abnormality of the parathyroid morphology (HP:0011766)	1.64860644
79	Urinary urgency (HP:0000012)	1.64859743
80	Abnormality of the anterior horn cell (HP:0006802)	1.64022613
81	Degeneration of anterior horn cells (HP:0002398)	1.64022613
82	Arteriovenous malformation (HP:0100026)	1.63797973
83	Type I transferrin isoform profile (HP:0003642)	1.63623095
84	Acute lymphatic leukemia (HP:0006721)	1.63255860
85	Abnormal large intestine physiology (HP:0012700)	1.62508301
86	Genital tract atresia (HP:0001827)	1.62506492
87	Abnormal lung lobation (HP:0002101)	1.61304696
88	Duplication of thumb phalanx (HP:0009942)	1.59788820
89	Myelodysplasia (HP:0002863)	1.59441281
90	Back pain (HP:0003418)	1.58229964
91	Peripheral hypomyelination (HP:0007182)	1.58063129
92	Horseshoe kidney (HP:0000085)	1.57478566
93	Septate vagina (HP:0001153)	1.53694469
94	Breast hypoplasia (HP:0003187)	1.53473786
95	EEG with generalized epileptiform discharges (HP:0011198)	1.51644667
96	Aganglionic megacolon (HP:0002251)	1.51446623
97	Cafe-au-lait spot (HP:0000957)	1.51393691
98	Abnormality of lateral ventricle (HP:0030047)	1.51265722
99	Limb dystonia (HP:0002451)	1.50975845
100	Drooling (HP:0002307)	1.50171928

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	4.03951523
2	PNCK	3.16373613
3	CDK8	2.56481925
4	BMPR1B	2.35816791
5	MARK1	2.30916572
6	WEE1	2.27862193
7	BCKDK	2.14579977
8	SRPK1	2.09752687
9	PRKD3	2.07896909
10	ICK	2.05724710
11	TSSK6	1.93668797
12	CASK	1.93152441
13	TTK	1.82129263
14	CHEK2	1.81856456
15	MAP2K7	1.78013670
16	ATR	1.72104048
17	VRK2	1.69595494
18	MAPK13	1.66896223
19	CDK12	1.63771193
20	SIK2	1.62484671
21	NME1	1.57402061
22	PLK4	1.53613746
23	CDK7	1.51710668
24	AURKA	1.47841587
25	DYRK2	1.46995806
26	CSNK1G3	1.43237790
27	BUB1	1.43193838
28	MAP4K2	1.39971123
29	MAP3K4	1.39168250
30	PLK1	1.37332418
31	PKN2	1.36100280
32	CSNK1A1L	1.31874566
33	TRIM28	1.23689069
34	BCR	1.22577966
35	CHEK1	1.22244603
36	PIM2	1.18277600
37	PASK	1.15601661
38	PBK	1.15282887
39	CSNK1G2	1.15203584
40	NTRK2	1.12194104
41	NEK2	1.12045830
42	IRAK3	1.10586195
43	ERBB3	1.09403799
44	BRSK1	1.08743082
45	ATM	1.08715710
46	EEF2K	1.05995872
47	UHMK1	1.05030483
48	CDK11A	1.04101932
49	TRIB3	1.00691477
50	RPS6KA4	0.99830189
51	CDK14	0.98744571
52	AURKB	0.98655575
53	CDK15	0.94763062
54	CSNK1G1	0.93960077
55	CDK2	0.93620501
56	CDK18	0.91965618
57	CDK19	0.87770238
58	BRSK2	0.87143605
59	MINK1	0.86189183
60	CDK4	0.86064593
61	VRK1	0.85597478
62	NEK1	0.83179272
63	CDK1	0.82933332
64	LMTK2	0.82307136
65	TESK2	0.80802642
66	CLK1	0.78326475
67	BRD4	0.77102551
68	CCNB1	0.75523121
69	MAPK15	0.73981178
70	BRAF	0.70390521
71	MAP2K4	0.70008125
72	MAP3K10	0.66125787
73	SMG1	0.62988958
74	CAMK1G	0.61179436
75	INSRR	0.59466962
76	TESK1	0.59310551
77	CDK3	0.58826101
78	DYRK1A	0.58693035
79	CSNK1E	0.58237253
80	WNK3	0.56232602
81	ARAF	0.55871242
82	RPS6KA5	0.53951206
83	PRKDC	0.53542431
84	GSK3B	0.50224585
85	PRKCZ	0.48711866
86	CSNK2A1	0.48550184
87	MAPK10	0.47537272
88	CSNK2A2	0.47446537
89	MET	0.47131615
90	PRKCI	0.46798769
91	EPHA4	0.45710363
92	KSR1	0.45429144
93	EIF2AK2	0.45336807
94	PLK3	0.44218036
95	PRKCG	0.44072445
96	DYRK3	0.43824548
97	MAPK9	0.43362876
98	MAP3K5	0.43059626
99	EIF2AK1	0.42990982
100	SIK1	0.42932216

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.16689647
2	Mismatch repair_Homo sapiens_hsa03430	3.56401835
3	Base excision repair_Homo sapiens_hsa03410	3.31076042
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.87473374
5	Homologous recombination_Homo sapiens_hsa03440	2.68067768
6	Cell cycle_Homo sapiens_hsa04110	2.49503075
7	Spliceosome_Homo sapiens_hsa03040	2.27809409
8	Sulfur relay system_Homo sapiens_hsa04122	2.19698090
9	Nucleotide excision repair_Homo sapiens_hsa03420	2.16517560
10	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.16375435
11	Folate biosynthesis_Homo sapiens_hsa00790	2.09705646
12	Basal transcription factors_Homo sapiens_hsa03022	1.90836350
13	RNA transport_Homo sapiens_hsa03013	1.76425301
14	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.75678922
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.73873824
16	One carbon pool by folate_Homo sapiens_hsa00670	1.72142086
17	Nicotine addiction_Homo sapiens_hsa05033	1.64250353
18	Non-homologous end-joining_Homo sapiens_hsa03450	1.60056054
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.59197565
20	Oocyte meiosis_Homo sapiens_hsa04114	1.57417794
21	RNA polymerase_Homo sapiens_hsa03020	1.54692046
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.52397556
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.51649779
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.46975955
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.39969433
26	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.39275189
27	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.25115165
28	Parkinsons disease_Homo sapiens_hsa05012	1.19719911
29	Fatty acid elongation_Homo sapiens_hsa00062	1.18201760
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16247288
31	Regulation of autophagy_Homo sapiens_hsa04140	1.15054137
32	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.14253020
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.13951760
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11423885
35	Huntingtons disease_Homo sapiens_hsa05016	1.08725548
36	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.03001811
37	RNA degradation_Homo sapiens_hsa03018	0.99903019
38	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.98302010
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.97187433
40	Lysine degradation_Homo sapiens_hsa00310	0.94294092
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91824603
42	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.90829584
43	Purine metabolism_Homo sapiens_hsa00230	0.90554759
44	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.90399691
45	Phototransduction_Homo sapiens_hsa04744	0.89926409
46	Proteasome_Homo sapiens_hsa03050	0.88906629
47	Carbon metabolism_Homo sapiens_hsa01200	0.88839586
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88329990
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.79809160
50	GABAergic synapse_Homo sapiens_hsa04727	0.79211707
51	Protein export_Homo sapiens_hsa03060	0.78684657
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.76211852
53	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.71144657
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.69681594
55	Ribosome_Homo sapiens_hsa03010	0.69492015
56	Vibrio cholerae infection_Homo sapiens_hsa05110	0.68133496
57	Gap junction_Homo sapiens_hsa04540	0.66859563
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.64234559
59	Alcoholism_Homo sapiens_hsa05034	0.62633727
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62209624
61	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60554918
62	Butanoate metabolism_Homo sapiens_hsa00650	0.55989397
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55082576
64	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51531910
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.50909431
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.50415574
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.50275481
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.49797345
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.49780632
70	Taste transduction_Homo sapiens_hsa04742	0.49737660
71	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.49408180
72	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.48703218
73	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.47967802
74	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47709668
75	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46278704
76	Cocaine addiction_Homo sapiens_hsa05030	0.46023588
77	Pentose phosphate pathway_Homo sapiens_hsa00030	0.43803367
78	Propanoate metabolism_Homo sapiens_hsa00640	0.43353608
79	Alzheimers disease_Homo sapiens_hsa05010	0.42873219
80	Metabolic pathways_Homo sapiens_hsa01100	0.41678049
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40789402
82	Melanoma_Homo sapiens_hsa05218	0.40116700
83	Axon guidance_Homo sapiens_hsa04360	0.39962198
84	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.37950586
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.36281762
86	AMPK signaling pathway_Homo sapiens_hsa04152	0.35208016
87	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34100329
88	Glutamatergic synapse_Homo sapiens_hsa04724	0.33285604
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.32653258
90	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.31928155
91	Circadian entrainment_Homo sapiens_hsa04713	0.31594704
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30681954
93	MicroRNAs in cancer_Homo sapiens_hsa05206	0.30054123
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.29260248
95	Peroxisome_Homo sapiens_hsa04146	0.28834265
96	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.28350204
97	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27524266
98	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.27037866
99	Morphine addiction_Homo sapiens_hsa05032	0.26603159
100	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.23266068

C19ORF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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