ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.86406440
2	behavioral response to nicotine (GO:0035095)	4.39961586
3	protein complex biogenesis (GO:0070271)	4.11576783
4	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.10946042
5	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.10946042
6	NADH dehydrogenase complex assembly (GO:0010257)	4.10946042
7	ATP synthesis coupled proton transport (GO:0015986)	4.01795116
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.01795116
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.79299004
10	negative regulation of telomere maintenance (GO:0032205)	3.75815532
11	mitochondrial respiratory chain complex assembly (GO:0033108)	3.70355801
12	metallo-sulfur cluster assembly (GO:0031163)	3.66545528
13	iron-sulfur cluster assembly (GO:0016226)	3.66545528
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53447811
15	base-excision repair, AP site formation (GO:0006285)	3.50386149
16	positive regulation of prostaglandin secretion (GO:0032308)	3.27583967
17	electron transport chain (GO:0022900)	3.21183794
18	negative regulation of mast cell activation (GO:0033004)	3.20607194
19	respiratory electron transport chain (GO:0022904)	3.17905062
20	purine deoxyribonucleotide catabolic process (GO:0009155)	3.01410629
21	chaperone-mediated protein transport (GO:0072321)	2.98790701
22	fucose catabolic process (GO:0019317)	2.97174802
23	L-fucose metabolic process (GO:0042354)	2.97174802
24	L-fucose catabolic process (GO:0042355)	2.97174802
25	cytochrome complex assembly (GO:0017004)	2.96634772
26	positive regulation of defense response to virus by host (GO:0002230)	2.95892016
27	positive regulation of fatty acid transport (GO:2000193)	2.94019059
28	negative regulation of appetite (GO:0032099)	2.93369033
29	negative regulation of response to food (GO:0032096)	2.93369033
30	response to interferon-beta (GO:0035456)	2.87372625
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.86547933
32	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.85065596
33	platelet dense granule organization (GO:0060155)	2.81821392
34	autophagic vacuole fusion (GO:0000046)	2.81478923
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.81004234
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.81004234
37	phosphatidylglycerol biosynthetic process (GO:0006655)	2.79770292
38	cellular response to interferon-beta (GO:0035458)	2.77647251
39	mannosylation (GO:0097502)	2.77079185
40	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.77075786
41	deoxyribonucleotide catabolic process (GO:0009264)	2.73468673
42	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73315502
43	positive regulation of icosanoid secretion (GO:0032305)	2.71959926
44	respiratory chain complex IV assembly (GO:0008535)	2.71645801
45	ubiquinone biosynthetic process (GO:0006744)	2.71636731
46	protein-cofactor linkage (GO:0018065)	2.71408559
47	positive regulation of antigen processing and presentation (GO:0002579)	2.69627407
48	indole-containing compound catabolic process (GO:0042436)	2.68782636
49	indolalkylamine catabolic process (GO:0046218)	2.68782636
50	tryptophan catabolic process (GO:0006569)	2.68782636
51	hydrogen ion transmembrane transport (GO:1902600)	2.66750396
52	cytidine metabolic process (GO:0046087)	2.65186518
53	cytidine catabolic process (GO:0006216)	2.65186518
54	cytidine deamination (GO:0009972)	2.65186518
55	GTP biosynthetic process (GO:0006183)	2.64813153
56	positive regulation of calcium-mediated signaling (GO:0050850)	2.63615650
57	kynurenine metabolic process (GO:0070189)	2.63401988
58	sulfation (GO:0051923)	2.62883272
59	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60458893
60	ATP biosynthetic process (GO:0006754)	2.59083864
61	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.56184330
62	viral transcription (GO:0019083)	2.52764990
63	protein polyglutamylation (GO:0018095)	2.51495416
64	proton transport (GO:0015992)	2.50803293
65	NAD biosynthetic process (GO:0009435)	2.49740685
66	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.47498586
67	hydrogen transport (GO:0006818)	2.46556445
68	water-soluble vitamin biosynthetic process (GO:0042364)	2.43837845
69	indolalkylamine metabolic process (GO:0006586)	2.43534979
70	positive regulation of organic acid transport (GO:0032892)	2.42146214
71	negative regulation of B cell apoptotic process (GO:0002903)	2.40021383
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.39909494
73	GPI anchor metabolic process (GO:0006505)	2.38546531
74	deoxyribose phosphate catabolic process (GO:0046386)	2.38283567
75	cellular response to exogenous dsRNA (GO:0071360)	2.37721244
76	synaptic transmission, cholinergic (GO:0007271)	2.37250777
77	detection of light stimulus involved in visual perception (GO:0050908)	2.37000867
78	detection of light stimulus involved in sensory perception (GO:0050962)	2.37000867
79	purine deoxyribonucleotide metabolic process (GO:0009151)	2.33813076
80	cellular response to ATP (GO:0071318)	2.32866330
81	pyrimidine nucleotide catabolic process (GO:0006244)	2.31570813
82	ubiquinone metabolic process (GO:0006743)	2.29507427
83	response to pheromone (GO:0019236)	2.29461632
84	protein neddylation (GO:0045116)	2.28273827
85	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.28269845
86	ATP hydrolysis coupled proton transport (GO:0015991)	2.28269845
87	cellular biogenic amine catabolic process (GO:0042402)	2.26719581
88	amine catabolic process (GO:0009310)	2.26719581
89	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.25015884
90	translational termination (GO:0006415)	2.24755586
91	negative regulation of interleukin-1 beta production (GO:0032691)	2.24645820
92	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.24249145
93	pseudouridine synthesis (GO:0001522)	2.23700325
94	regulation of defense response to virus by host (GO:0050691)	2.21003545
95	regulation of prostaglandin secretion (GO:0032306)	2.20762958
96	tRNA modification (GO:0006400)	2.19806618
97	regulation of antigen processing and presentation (GO:0002577)	2.19729259
98	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.19029121
99	organelle membrane fusion (GO:0090174)	2.18848593
100	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.18474034

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.22796474
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.95920829
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86806975
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.84135154
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56138117
6	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.38953014
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.32301629
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.30082439
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.29900243
10	BCL6_27268052_Chip-Seq_Bcells_Human	2.19075977
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.02720440
12	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	2.01552907
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.00864487
14	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.98092708
15	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.92283222
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.86797384
17	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.82599327
18	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.80818415
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.80110556
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.80009514
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.75497686
22	P68_20966046_ChIP-Seq_HELA_Human	1.73402100
23	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.72976916
24	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.71427941
25	E2F1_20622854_ChIP-Seq_HELA_Human	1.71262185
26	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.68800446
27	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66097025
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.63260127
29	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.62660321
30	* CTCF_20526341_ChIP-Seq_ESCs_Human	1.62600741
31	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.62586195
32	* VDR_21846776_ChIP-Seq_THP-1_Human	1.58598976
33	ERA_21632823_ChIP-Seq_H3396_Human	1.58288092
34	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.57281910
35	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.56150527
36	PHF8_20622854_ChIP-Seq_HELA_Human	1.55391519
37	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.55245593
38	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46076934
39	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.45072160
40	TAF2_19829295_ChIP-Seq_ESCs_Human	1.44691704
41	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.44442982
42	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.44052015
43	VDR_23849224_ChIP-Seq_CD4+_Human	1.42054839
44	SA1_27219007_Chip-Seq_Bcells_Human	1.41868972
45	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.41464774
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39394149
47	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30529815
48	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.30453762
49	P300_27268052_Chip-Seq_Bcells_Human	1.29655398
50	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.28994151
51	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.27338973
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27315231
53	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.26478158
54	LXR_22292898_ChIP-Seq_THP-1_Human	1.25557587
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.24021427
56	CTCF_27219007_Chip-Seq_Bcells_Human	1.23990471
57	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.22986634
58	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.21599366
59	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.21282851
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.20072514
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19301876
62	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.18656037
63	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.18524124
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.18517581
65	STAT1_20625510_ChIP-Seq_HELA_Human	1.18341695
66	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.16718347
67	IRF1_19129219_ChIP-ChIP_H3396_Human	1.15962626
68	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.15735734
69	VDR_22108803_ChIP-Seq_LS180_Human	1.15683310
70	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.15464264
71	RAC3_21632823_ChIP-Seq_H3396_Human	1.15226018
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.14965127
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.14481401
74	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.13505615
75	MAF_26560356_Chip-Seq_TH2_Human	1.12345123
76	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11260267
77	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10585004
78	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.10569258
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.10462527
80	* TP53_22573176_ChIP-Seq_HFKS_Human	1.10461350
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.10400814
82	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.10094440
83	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.08968091
84	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.08704286
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.08647550
86	GABP_19822575_ChIP-Seq_HepG2_Human	1.08335039
87	SPI1_20517297_ChIP-Seq_HL60_Human	1.08096287
88	OCT4_20526341_ChIP-Seq_ESCs_Human	1.08022058
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08002992
90	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07224906
91	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06212511
92	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05288856
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.05023283
94	* CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.04269559
95	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.04196211
96	FOXP3_21729870_ChIP-Seq_TREG_Human	1.04163329
97	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03141309
98	P53_21459846_ChIP-Seq_SAOS-2_Human	1.02911740
99	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.02853320
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01575610

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	2.60504290
2	MP0003646_muscle_fatigue	2.59231181
3	MP0001968_abnormal_touch/_nociception	2.26040842
4	MP0003806_abnormal_nucleotide_metabolis	2.10886608
5	MP0002148_abnormal_hypersensitivity_rea	2.07415835
6	MP0002653_abnormal_ependyma_morphology	2.07225016
7	MP0002837_dystrophic_cardiac_calcinosis	1.96078527
8	MP0005645_abnormal_hypothalamus_physiol	1.92486061
9	MP0001835_abnormal_antigen_presentation	1.86726461
10	MP0000685_abnormal_immune_system	1.83068377
11	MP0003436_decreased_susceptibility_to	1.76583024
12	MP0008875_abnormal_xenobiotic_pharmacok	1.74629198
13	MP0005387_immune_system_phenotype	1.74602694
14	MP0001790_abnormal_immune_system	1.74602694
15	MP0002736_abnormal_nociception_after	1.74410537
16	MP0003724_increased_susceptibility_to	1.72673746
17	MP0001986_abnormal_taste_sensitivity	1.69611860
18	MP0002138_abnormal_hepatobiliary_system	1.66846205
19	MP0005551_abnormal_eye_electrophysiolog	1.64496397
20	MP0001800_abnormal_humoral_immune	1.61156091
21	MP0009379_abnormal_foot_pigmentation	1.60402731
22	MP0003011_delayed_dark_adaptation	1.58852793
23	MP0008872_abnormal_physiological_respon	1.58375531
24	MP0009764_decreased_sensitivity_to	1.54622173
25	MP0004145_abnormal_muscle_electrophysio	1.54299060
26	MP0002723_abnormal_immune_serum	1.53503821
27	MP0006082_CNS_inflammation	1.53397633
28	MP0009745_abnormal_behavioral_response	1.53197667
29	MP0009785_altered_susceptibility_to	1.52875394
30	MP0005000_abnormal_immune_tolerance	1.52814374
31	MP0001905_abnormal_dopamine_level	1.52370399
32	MP0004142_abnormal_muscle_tone	1.52022446
33	MP0005025_abnormal_response_to	1.51413088
34	MP0005646_abnormal_pituitary_gland	1.49644563
35	MP0006292_abnormal_olfactory_placode	1.48908095
36	MP0001873_stomach_inflammation	1.47704868
37	MP0002452_abnormal_antigen_presenting	1.39050526
38	MP0002272_abnormal_nervous_system	1.33968026
39	MP0002420_abnormal_adaptive_immunity	1.33592955
40	MP0001819_abnormal_immune_cell	1.32715350
41	MP0006036_abnormal_mitochondrial_physio	1.31308485
42	MP0003880_abnormal_central_pattern	1.29393947
43	MP0002733_abnormal_thermal_nociception	1.29038396
44	MP0002064_seizures	1.28276193
45	MP0001970_abnormal_pain_threshold	1.27654163
46	MP0004742_abnormal_vestibular_system	1.26452686
47	MP0005084_abnormal_gallbladder_morpholo	1.21269958
48	MP0002419_abnormal_innate_immunity	1.21047337
49	MP0001501_abnormal_sleep_pattern	1.20921171
50	MP0002876_abnormal_thyroid_physiology	1.19552197
51	MP0000372_irregular_coat_pigmentation	1.16165086
52	MP0003195_calcinosis	1.14949722
53	MP0009046_muscle_twitch	1.14724113
54	MP0002277_abnormal_respiratory_mucosa	1.12398898
55	MP0002822_catalepsy	1.12236267
56	MP0001663_abnormal_digestive_system	1.11126870
57	MP0003878_abnormal_ear_physiology	1.11029553
58	MP0005377_hearing/vestibular/ear_phenot	1.11029553
59	MP0001486_abnormal_startle_reflex	1.09898959
60	MP0002735_abnormal_chemical_nociception	1.06017171
61	MP0006072_abnormal_retinal_apoptosis	1.05808017
62	MP0002572_abnormal_emotion/affect_behav	1.05674294
63	MP0004130_abnormal_muscle_cell	1.05632161
64	MP0009333_abnormal_splenocyte_physiolog	1.05303138
65	MP0001485_abnormal_pinna_reflex	1.05034922
66	MP0002638_abnormal_pupillary_reflex	0.99249330
67	MP0004147_increased_porphyrin_level	0.98178125
68	MP0000716_abnormal_immune_system	0.97840268
69	MP0003186_abnormal_redox_activity	0.97719415
70	MP0002102_abnormal_ear_morphology	0.97356001
71	MP0009840_abnormal_foam_cell	0.96948777
72	MP0002405_respiratory_system_inflammati	0.96485839
73	MP0004043_abnormal_pH_regulation	0.95755467
74	MP0001845_abnormal_inflammatory_respons	0.95193105
75	MP0006276_abnormal_autonomic_nervous	0.95176182
76	MP0003635_abnormal_synaptic_transmissio	0.94223099
77	MP0005423_abnormal_somatic_nervous	0.93418938
78	MP0008995_early_reproductive_senescence	0.93012471
79	MP0005058_abnormal_lysosome_morphology	0.92761105
80	MP0002254_reproductive_system_inflammat	0.92237684
81	MP0002163_abnormal_gland_morphology	0.92227272
82	MP0005075_abnormal_melanosome_morpholog	0.91667593
83	MP0008469_abnormal_protein_level	0.90144406
84	MP0005389_reproductive_system_phenotype	0.89908412
85	MP0004133_heterotaxia	0.88968952
86	MP0003137_abnormal_impulse_conducting	0.88746630
87	MP0001919_abnormal_reproductive_system	0.88239130
88	MP0005167_abnormal_blood-brain_barrier	0.87615841
89	MP0000604_amyloidosis	0.87475564
90	MP0001533_abnormal_skeleton_physiology	0.87412125
91	MP0009278_abnormal_bone_marrow	0.86019656
92	MP0000689_abnormal_spleen_morphology	0.85170878
93	MP0001963_abnormal_hearing_physiology	0.84166620
94	MP0001764_abnormal_homeostasis	0.83205296
95	MP0002557_abnormal_social/conspecific_i	0.81958944
96	MP0005253_abnormal_eye_physiology	0.81790768
97	MP0003763_abnormal_thymus_physiology	0.81470428
98	MP0002933_joint_inflammation	0.81194408
99	MP0001529_abnormal_vocalization	0.80820382
100	MP0003638_abnormal_response/metabolism_	0.79904761

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Mitochondrial inheritance (HP:0001427)	3.81243987
2	Acute necrotizing encephalopathy (HP:0006965)	3.64874792
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.57467885
4	Hepatocellular necrosis (HP:0001404)	3.53886985
5	Congenital stationary night blindness (HP:0007642)	3.42501403
6	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.39673589
7	Increased CSF lactate (HP:0002490)	3.26640607
8	3-Methylglutaconic aciduria (HP:0003535)	3.23545758
9	Hepatic necrosis (HP:0002605)	3.19590821
10	Acute encephalopathy (HP:0006846)	3.16153841
11	Increased intramyocellular lipid droplets (HP:0012240)	2.96587981
12	Progressive macrocephaly (HP:0004481)	2.96275536
13	Elevated erythrocyte sedimentation rate (HP:0003565)	2.95606389
14	Abnormal rod and cone electroretinograms (HP:0008323)	2.94577761
15	Abnormal number of erythroid precursors (HP:0012131)	2.89180431
16	Attenuation of retinal blood vessels (HP:0007843)	2.84209107
17	Renal Fanconi syndrome (HP:0001994)	2.81633666
18	Increased muscle lipid content (HP:0009058)	2.81355818
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.76038984
20	Stomatitis (HP:0010280)	2.72117353
21	Abolished electroretinogram (ERG) (HP:0000550)	2.68803476
22	Optic disc pallor (HP:0000543)	2.68082731
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.64277501
24	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.64277501
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.64232396
26	Pancreatic cysts (HP:0001737)	2.60718107
27	Pendular nystagmus (HP:0012043)	2.58206928
28	Abnormality of glycolipid metabolism (HP:0010969)	2.52807541
29	Abnormality of liposaccharide metabolism (HP:0010968)	2.52807541
30	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.52807541
31	Abnormality of cells of the erythroid lineage (HP:0012130)	2.51706152
32	Molar tooth sign on MRI (HP:0002419)	2.50438353
33	Abnormality of midbrain morphology (HP:0002418)	2.50438353
34	Lactic acidosis (HP:0003128)	2.49889985
35	Lipid accumulation in hepatocytes (HP:0006561)	2.44091625
36	Progressive microcephaly (HP:0000253)	2.42477685
37	True hermaphroditism (HP:0010459)	2.40199863
38	Abnormality of alanine metabolism (HP:0010916)	2.35185405
39	Hyperalaninemia (HP:0003348)	2.35185405
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35185405
41	Increased hepatocellular lipid droplets (HP:0006565)	2.34351477
42	Pancreatic fibrosis (HP:0100732)	2.34345750
43	Increased serum lactate (HP:0002151)	2.33425024
44	Type II lissencephaly (HP:0007260)	2.33189442
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.26785477
46	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.19386544
47	Nephronophthisis (HP:0000090)	2.18374754
48	Increased IgM level (HP:0003496)	2.14935830
49	IgG deficiency (HP:0004315)	2.13530333
50	Decreased central vision (HP:0007663)	2.12917238
51	Mesangial abnormality (HP:0001966)	2.12471071
52	Agitation (HP:0000713)	2.11463443
53	Methylmalonic aciduria (HP:0012120)	2.09964725
54	Generalized aminoaciduria (HP:0002909)	2.08766530
55	Panhypogammaglobulinemia (HP:0003139)	2.06110681
56	Polydipsia (HP:0001959)	2.05366146
57	Abnormal drinking behavior (HP:0030082)	2.05366146
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05170239
59	Dicarboxylic aciduria (HP:0003215)	2.05170239
60	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.02113982
61	Cerebral edema (HP:0002181)	2.02091587
62	Respiratory failure (HP:0002878)	2.00031746
63	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.98693954
64	Increased cerebral lipofuscin (HP:0011813)	1.98482787
65	Concave nail (HP:0001598)	1.95987001
66	Cerebral palsy (HP:0100021)	1.94513420
67	Medial flaring of the eyebrow (HP:0010747)	1.90088390
68	Congenital, generalized hypertrichosis (HP:0004540)	1.89126015
69	Mediastinal lymphadenopathy (HP:0100721)	1.87414569
70	Severe muscular hypotonia (HP:0006829)	1.86978526
71	Recurrent fungal infections (HP:0002841)	1.85966844
72	Polyphagia (HP:0002591)	1.82932435
73	Lethargy (HP:0001254)	1.81425730
74	Autoimmune thrombocytopenia (HP:0001973)	1.81349062
75	Severe visual impairment (HP:0001141)	1.79324878
76	Vacuolated lymphocytes (HP:0001922)	1.77823257
77	Exertional dyspnea (HP:0002875)	1.77293550
78	Mutism (HP:0002300)	1.77226220
79	Opisthotonus (HP:0002179)	1.77221514
80	Polyuria (HP:0000103)	1.75797221
81	Exercise intolerance (HP:0003546)	1.73000893
82	Severe combined immunodeficiency (HP:0004430)	1.72946089
83	Myositis (HP:0100614)	1.71775516
84	Recurrent cutaneous fungal infections (HP:0011370)	1.70993969
85	Chronic mucocutaneous candidiasis (HP:0002728)	1.70993969
86	Emotional lability (HP:0000712)	1.69457952
87	Prostate neoplasm (HP:0100787)	1.68698325
88	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.68676086
89	Myokymia (HP:0002411)	1.67468529
90	Abnormality of the renal medulla (HP:0100957)	1.66961862
91	Gliosis (HP:0002171)	1.66257982
92	Inability to walk (HP:0002540)	1.66252990
93	Glycosuria (HP:0003076)	1.65355030
94	Abnormality of urine glucose concentration (HP:0011016)	1.65355030
95	Cystic liver disease (HP:0006706)	1.64520492
96	Progressive cerebellar ataxia (HP:0002073)	1.64322959
97	Abnormality of the renal cortex (HP:0011035)	1.63874872
98	Agammaglobulinemia (HP:0004432)	1.63342548
99	Stomach cancer (HP:0012126)	1.63272146
100	Ketosis (HP:0001946)	1.62804180

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.48824788
2	MAP4K1	3.35117157
3	TAOK3	3.21053361
4	BCKDK	3.15911296
5	TXK	2.84824832
6	ADRBK2	2.74761353
7	MAP3K11	2.65254342
8	ZAK	2.48064987
9	NME2	2.20821372
10	TESK2	2.05403741
11	INSRR	1.88934832
12	KDR	1.88561986
13	FRK	1.86615268
14	GRK1	1.85483922
15	MAP4K2	1.84379531
16	VRK2	1.78859845
17	PINK1	1.76070282
18	IKBKB	1.71864494
19	KIT	1.50832300
20	GRK6	1.50112135
21	TNK2	1.41257317
22	DAPK2	1.39571024
23	CAMKK2	1.36336130
24	PIM2	1.35640364
25	TBK1	1.33438481
26	LIMK1	1.32897312
27	IKBKE	1.28969515
28	MAPKAPK3	1.27793113
29	MAPK13	1.20533354
30	DYRK2	1.17345637
31	ABL2	1.14995247
32	SYK	1.14643382
33	BLK	1.11114707
34	WNK4	1.09462184
35	MAP2K6	1.08923189
36	MUSK	1.07742320
37	FES	1.06811379
38	GRK7	1.04680725
39	MAPK15	1.02828219
40	BMPR1B	1.01526643
41	NUAK1	1.00348051
42	MAP2K2	0.99438933
43	SIK2	0.99002208
44	CDK19	0.97394147
45	ADRBK1	0.95435431
46	MAP2K7	0.95149157
47	VRK1	0.88019622
48	CAMKK1	0.86921179
49	RPS6KA5	0.86315791
50	WNK3	0.85995942
51	FLT3	0.84042059
52	STK16	0.83822503
53	PRKCQ	0.83333006
54	CSNK1G3	0.79084873
55	LYN	0.77329797
56	RIPK4	0.74915603
57	ACVR1B	0.74761610
58	BTK	0.74044673
59	GRK5	0.73715166
60	TESK1	0.73436789
61	RPS6KA6	0.72399391
62	CSF1R	0.71074813
63	PRKD2	0.69934445
64	MATK	0.69820807
65	PRKCG	0.68483057
66	LCK	0.68060064
67	PKN1	0.67193173
68	ITK	0.66380559
69	CSNK1G2	0.65781901
70	OXSR1	0.64990423
71	ZAP70	0.64433570
72	IRAK4	0.59087436
73	CAMK1	0.56989139
74	DAPK1	0.56897851
75	MAP3K4	0.56254602
76	CHUK	0.53584129
77	NME1	0.53279222
78	JAK3	0.52172346
79	PHKG1	0.51886011
80	PHKG2	0.51886011
81	CSNK1A1L	0.50117873
82	CSNK1G1	0.49700718
83	TIE1	0.46049408
84	DAPK3	0.46038530
85	MAPK12	0.45504721
86	PIM1	0.45458878
87	PRKACA	0.42956993
88	PRKCA	0.42651084
89	MAP3K13	0.40301255
90	AURKA	0.40171678
91	EPHA4	0.40147168
92	MAPK4	0.40123674
93	ERN1	0.40111982
94	MAP2K4	0.39212445
95	RPS6KC1	0.39041291
96	RPS6KL1	0.39041291
97	MARK3	0.38812206
98	OBSCN	0.38107244
99	NTRK2	0.37380599
100	PRKCD	0.37209158

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.69619797
2	Parkinsons disease_Homo sapiens_hsa05012	2.95876701
3	Sulfur relay system_Homo sapiens_hsa04122	2.66383543
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.64935497
5	Ribosome_Homo sapiens_hsa03010	2.57171494
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.46898650
7	Asthma_Homo sapiens_hsa05310	2.42857904
8	Allograft rejection_Homo sapiens_hsa05330	2.35968813
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.19594890
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.17691726
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.10471919
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.09576554
13	Alzheimers disease_Homo sapiens_hsa05010	2.00054613
14	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.99883954
15	Phototransduction_Homo sapiens_hsa04744	1.97862733
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.93041099
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.92986530
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89368891
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82649543
20	Type I diabetes mellitus_Homo sapiens_hsa04940	1.78885642
21	Huntingtons disease_Homo sapiens_hsa05016	1.74944989
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.73538689
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.67041922
24	RNA polymerase_Homo sapiens_hsa03020	1.65706604
25	Proteasome_Homo sapiens_hsa03050	1.58298588
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.55569100
27	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.49138414
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.48954398
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.48879157
30	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.42493112
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.34386820
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.31186101
33	Homologous recombination_Homo sapiens_hsa03440	1.27580859
34	Ether lipid metabolism_Homo sapiens_hsa00565	1.21516628
35	Nicotine addiction_Homo sapiens_hsa05033	1.20751405
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19920551
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.12307142
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11076050
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.09322073
40	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04240804
41	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.03467375
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.00863898
43	Sulfur metabolism_Homo sapiens_hsa00920	0.99573057
44	Lysosome_Homo sapiens_hsa04142	0.97644003
45	Peroxisome_Homo sapiens_hsa04146	0.93961212
46	Pyrimidine metabolism_Homo sapiens_hsa00240	0.91645822
47	Morphine addiction_Homo sapiens_hsa05032	0.91290274
48	Olfactory transduction_Homo sapiens_hsa04740	0.84557700
49	Base excision repair_Homo sapiens_hsa03410	0.83970777
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82847723
51	Other glycan degradation_Homo sapiens_hsa00511	0.79833859
52	Regulation of autophagy_Homo sapiens_hsa04140	0.78903377
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76504790
54	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.76167859
55	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.75768312
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75674608
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.75182331
58	Leishmaniasis_Homo sapiens_hsa05140	0.73117128
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73053097
60	Fanconi anemia pathway_Homo sapiens_hsa03460	0.70927810
61	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69307733
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69171437
63	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.67005837
64	Butanoate metabolism_Homo sapiens_hsa00650	0.64500564
65	Metabolic pathways_Homo sapiens_hsa01100	0.59693762
66	Purine metabolism_Homo sapiens_hsa00230	0.58941520
67	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.58236123
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57204306
69	Fatty acid elongation_Homo sapiens_hsa00062	0.56450708
70	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53563054
71	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53318667
72	Tuberculosis_Homo sapiens_hsa05152	0.51049160
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.50174672
74	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.49783510
75	Circadian entrainment_Homo sapiens_hsa04713	0.49657878
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49291331
77	Caffeine metabolism_Homo sapiens_hsa00232	0.48964842
78	Salivary secretion_Homo sapiens_hsa04970	0.47967398
79	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46881079
80	GABAergic synapse_Homo sapiens_hsa04727	0.45455886
81	Taste transduction_Homo sapiens_hsa04742	0.45104381
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.44837297
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42079954
84	Glutathione metabolism_Homo sapiens_hsa00480	0.41471185
85	RNA degradation_Homo sapiens_hsa03018	0.40879165
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.38578925
87	Calcium signaling pathway_Homo sapiens_hsa04020	0.37964843
88	Viral myocarditis_Homo sapiens_hsa05416	0.36840027
89	Protein export_Homo sapiens_hsa03060	0.36695826
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.36279364
91	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36204158
92	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.34508202
93	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.33772253
94	Osteoclast differentiation_Homo sapiens_hsa04380	0.33355738
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32604726
96	Fat digestion and absorption_Homo sapiens_hsa04975	0.32396507
97	Insulin secretion_Homo sapiens_hsa04911	0.30616319
98	Pertussis_Homo sapiens_hsa05133	0.28970111
99	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.28813284
100	Mineral absorption_Homo sapiens_hsa04978	0.28399618

C19ORF60

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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