C19ORF66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to type I interferon (GO:0071357)5.11017248
2type I interferon signaling pathway (GO:0060337)5.11017248
3response to type I interferon (GO:0034340)5.10177816
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01183735
5negative regulation of cell killing (GO:0031342)4.92516868
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92516868
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88345464
8positive regulation of gamma-delta T cell activation (GO:0046645)4.82898805
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.79170784
10antigen processing and presentation of endogenous antigen (GO:0019883)4.76868195
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.84160707
12interferon-gamma-mediated signaling pathway (GO:0060333)3.76947543
13immunoglobulin mediated immune response (GO:0016064)3.67196372
14negative regulation of interleukin-12 production (GO:0032695)3.66005316
15detection of bacterium (GO:0016045)3.64885789
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.61733276
17modulation by symbiont of host immune response (GO:0052553)3.61733276
18positive regulation by symbiont of host defense response (GO:0052509)3.61733276
19modulation by symbiont of host defense response (GO:0052031)3.61733276
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.61733276
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.61733276
22regulation of gamma-delta T cell activation (GO:0046643)3.60527404
23detection of other organism (GO:0098543)3.57594731
24macrophage activation involved in immune response (GO:0002281)3.54725529
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.53742040
26regulation of T cell tolerance induction (GO:0002664)3.53461859
27regulation of B cell receptor signaling pathway (GO:0050855)3.45028331
28regulation of dendritic cell antigen processing and presentation (GO:0002604)3.44067735
29response to peptidoglycan (GO:0032494)3.42962076
30germinal center formation (GO:0002467)3.39242247
31regulation of interferon-beta biosynthetic process (GO:0045357)3.33960743
32regulation of T-helper 1 cell differentiation (GO:0045625)3.32710404
33regulation of interferon-alpha production (GO:0032647)3.32253635
34negative regulation of lymphocyte mediated immunity (GO:0002707)3.30750099
35T cell migration (GO:0072678)3.30253520
36negative regulation of T cell mediated immunity (GO:0002710)3.29698412
37negative regulation of viral genome replication (GO:0045071)3.28913080
38response to interferon-alpha (GO:0035455)3.26555463
39defense response to protozoan (GO:0042832)3.26254367
40response to interferon-beta (GO:0035456)3.26077131
41negative regulation of cytokine production involved in immune response (GO:0002719)3.25303928
42NIK/NF-kappaB signaling (GO:0038061)3.24607521
43positive regulation of interferon-alpha production (GO:0032727)3.20405269
44regulation of regulatory T cell differentiation (GO:0045589)3.20194309
45regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.17251495
46response to muramyl dipeptide (GO:0032495)3.16420450
47regulation of tolerance induction (GO:0002643)3.12547093
48response to protozoan (GO:0001562)3.12356965
49regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10817806
50negative regulation of innate immune response (GO:0045824)3.09263096
51regulation of T cell mediated cytotoxicity (GO:0001914)3.07500226
52positive regulation of tolerance induction (GO:0002645)3.06946972
53regulation of antigen processing and presentation (GO:0002577)3.06774212
54negative thymic T cell selection (GO:0045060)3.06535007
55negative regulation of leukocyte mediated immunity (GO:0002704)3.05960015
56myeloid dendritic cell differentiation (GO:0043011)3.05574363
57detection of external biotic stimulus (GO:0098581)3.05265850
58regulation of gamma-delta T cell differentiation (GO:0045586)3.03721571
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.01679275
60positive regulation of type 2 immune response (GO:0002830)3.00890557
61positive regulation of antigen processing and presentation (GO:0002579)3.00829008
62leukocyte aggregation (GO:0070486)2.99717154
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.96782976
64positive thymic T cell selection (GO:0045059)2.95817943
65response to interleukin-15 (GO:0070672)2.95587501
66negative T cell selection (GO:0043383)2.95543763
67positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91325386
68neutrophil activation involved in immune response (GO:0002283)2.89804986
69tolerance induction (GO:0002507)2.89546551
70cellular response to interferon-gamma (GO:0071346)2.88158097
71negative regulation of erythrocyte differentiation (GO:0045647)2.87089870
72B cell receptor signaling pathway (GO:0050853)2.83839390
73regulation of type 2 immune response (GO:0002828)2.83422543
74myeloid dendritic cell activation (GO:0001773)2.81792933
75regulation of natural killer cell mediated immunity (GO:0002715)2.78584576
76regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.78584576
77T-helper 1 type immune response (GO:0042088)2.77679876
78cellular response to interleukin-15 (GO:0071350)2.75953254
79regulation of interleukin-2 biosynthetic process (GO:0045076)2.73650530
80B cell mediated immunity (GO:0019724)2.73177931
81negative regulation of type 2 immune response (GO:0002829)2.70950640
82response to interferon-gamma (GO:0034341)2.70462086
83regulation of alpha-beta T cell proliferation (GO:0046640)2.69604009
84thymic T cell selection (GO:0045061)2.69065051
85positive regulation of humoral immune response (GO:0002922)2.68495112
86detection of molecule of bacterial origin (GO:0032490)2.67829805
87cellular response to exogenous dsRNA (GO:0071360)2.67384467
88cellular response to interferon-beta (GO:0035458)2.65970124
89myeloid cell activation involved in immune response (GO:0002275)2.64792301
90response to host immune response (GO:0052572)2.64409502
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.64409502
92interferon-gamma secretion (GO:0072643)2.63743971
93detection of biotic stimulus (GO:0009595)2.63478387
94negative regulation of production of molecular mediator of immune response (GO:0002701)2.62041908
95regulation of leukocyte mediated cytotoxicity (GO:0001910)2.61882167
96regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.61633835
97CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.60857287
98T cell selection (GO:0045058)2.59700081
99interferon-gamma production (GO:0032609)2.59597684
100regulation of interleukin-12 production (GO:0032655)2.58864013

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.63075545
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.30969284
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.76158145
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.64695575
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.64174463
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.47658938
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95425746
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66853273
9RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.55663728
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54772069
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.54397384
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.33189112
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32526568
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26152843
15VDR_21846776_ChIP-Seq_THP-1_Human2.22307729
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21847802
17RUNX_20019798_ChIP-Seq_JUKART_Human2.19824424
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19070697
19MAF_26560356_Chip-Seq_TH1_Human2.15906813
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.13642040
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.11594952
22VDR_24763502_ChIP-Seq_THP-1_Human2.01950999
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99880545
24MYB_26560356_Chip-Seq_TH2_Human1.93888018
25MYC_22102868_ChIP-Seq_BL_Human1.88589368
26KDM2B_26808549_Chip-Seq_SUP-B15_Human1.87302309
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86833928
28LXR_22292898_ChIP-Seq_THP-1_Human1.80175491
29VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79025715
30UTX_26944678_Chip-Seq_JUKART_Human1.78614484
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77147720
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.75207001
33MAF_26560356_Chip-Seq_TH2_Human1.72188324
34MYB_26560356_Chip-Seq_TH1_Human1.71103373
35SPI1_23547873_ChIP-Seq_NB4_Human1.70209199
36TCF7_22412390_ChIP-Seq_EML_Mouse1.67725550
37SCL_19346495_ChIP-Seq_HPC-7_Human1.65990370
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65631151
39SPI1_23127762_ChIP-Seq_K562_Human1.65012457
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.63904802
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.62996278
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.61808072
43KDM2B_26808549_Chip-Seq_DND41_Human1.61786608
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58909487
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58635274
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56297283
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.54820785
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.50705951
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.48197857
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44927254
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42041067
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38400111
53VDR_24787735_ChIP-Seq_THP-1_Human1.38123119
54GATA3_27048872_Chip-Seq_THYMUS_Human1.33730869
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32717570
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31138876
57* BCL6_27268052_Chip-Seq_Bcells_Human1.30759411
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.30291260
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.28763339
60FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.27456959
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.25310246
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25099664
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24387265
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23465322
65* BCOR_27268052_Chip-Seq_Bcells_Human1.20538420
66GATA2_21666600_ChIP-Seq_HMVEC_Human1.18607749
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16945217
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.16365702
69RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16110447
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15095312
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14810431
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14735017
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14564626
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14032637
75GATA1_19941826_ChIP-Seq_K562_Human1.12883159
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11531910
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11307447
78GATA3_26560356_Chip-Seq_TH2_Human1.08824088
79CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07407550
80PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03994216
81LXR_22158963_ChIP-Seq_LIVER_Mouse1.03904938
82EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03783069
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03291036
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01752963
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01032996
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00723652
87GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99228840
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99012958
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.98237832
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98129602
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97984058
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97829055
93KDM2B_26808549_Chip-Seq_JURKAT_Human0.96423228
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95295997
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95006835
96* P68_20966046_ChIP-Seq_HELA_Human0.95001954
97GATA1_22025678_ChIP-Seq_K562_Human0.94527027
98RACK7_27058665_Chip-Seq_MCF-7_Human0.93074670
99SA1_27219007_Chip-Seq_Bcells_Human0.92710750
100* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92668500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.82980107
2MP0003303_peritoneal_inflammation3.82661077
3MP0001835_abnormal_antigen_presentation3.82239753
4MP0003724_increased_susceptibility_to3.80898961
5MP0009785_altered_susceptibility_to3.25347090
6MP0005671_abnormal_response_to3.20906619
7MP0005387_immune_system_phenotype3.11408044
8MP0001790_abnormal_immune_system3.11408044
9MP0005000_abnormal_immune_tolerance2.98118826
10MP0001800_abnormal_humoral_immune2.88145209
11MP0000685_abnormal_immune_system2.81502520
12MP0005025_abnormal_response_to2.80219994
13MP0006082_CNS_inflammation2.71612955
14MP0002148_abnormal_hypersensitivity_rea2.66944140
15MP0002419_abnormal_innate_immunity2.56994107
16MP0002723_abnormal_immune_serum2.55726009
17MP0002452_abnormal_antigen_presenting2.41046761
18MP0002139_abnormal_hepatobiliary_system2.35145086
19MP0003763_abnormal_thymus_physiology2.28609975
20MP0002420_abnormal_adaptive_immunity2.24205645
21MP0001819_abnormal_immune_cell2.23614464
22MP0003300_gastrointestinal_ulcer2.23180148
23MP0002138_abnormal_hepatobiliary_system2.12036620
24MP0010155_abnormal_intestine_physiology2.10268782
25MP0001533_abnormal_skeleton_physiology2.09448312
26MP0009333_abnormal_splenocyte_physiolog1.91352007
27MP0004510_myositis1.90592351
28MP0004947_skin_inflammation1.86296483
29MP0001845_abnormal_inflammatory_respons1.84227477
30MP0009764_decreased_sensitivity_to1.80889106
31MP0005464_abnormal_platelet_physiology1.80575602
32MP0005058_abnormal_lysosome_morphology1.77681761
33MP0002405_respiratory_system_inflammati1.75108315
34MP0000716_abnormal_immune_system1.73141702
35MP0003191_abnormal_cellular_cholesterol1.72997875
36MP0008469_abnormal_protein_level1.69378452
37MP0009840_abnormal_foam_cell1.68722808
38MP0002398_abnormal_bone_marrow1.68008629
39MP0003172_abnormal_lysosome_physiology1.64137673
40MP0005360_urolithiasis1.46816470
41MP0003075_altered_response_to1.42259775
42MP0009278_abnormal_bone_marrow1.40794336
43MP0000689_abnormal_spleen_morphology1.39743672
44MP0005451_abnormal_body_composition1.38640609
45MP0002429_abnormal_blood_cell1.34094942
46MP0002998_abnormal_bone_remodeling1.32138349
47MP0002722_abnormal_immune_system1.31290661
48MP0002933_joint_inflammation1.28259557
49MP0000604_amyloidosis1.26672417
50MP0005310_abnormal_salivary_gland1.25281649
51MP0003866_abnormal_defecation1.24227664
52MP0001853_heart_inflammation1.23375216
53MP0005166_decreased_susceptibility_to1.22837901
54MP0005365_abnormal_bile_salt1.22603072
55MP0005397_hematopoietic_system_phenotyp1.20849873
56MP0001545_abnormal_hematopoietic_system1.20849873
57MP0003183_abnormal_peptide_metabolism1.16449130
58MP0001873_stomach_inflammation1.15058156
59MP0002166_altered_tumor_susceptibility1.14242567
60MP0000858_altered_metastatic_potential1.13462301
61MP0003195_calcinosis1.12832343
62MP0009763_increased_sensitivity_to1.07188340
63MP0000465_gastrointestinal_hemorrhage1.05370764
64MP0000703_abnormal_thymus_morphology1.04860582
65MP0001851_eye_inflammation1.02964216
66MP0003448_altered_tumor_morphology1.01338562
67MP0000343_altered_response_to0.98918494
68MP0003690_abnormal_glial_cell0.96417094
69MP0003045_fibrosis0.94218109
70MP0005390_skeleton_phenotype0.92350451
71MP0008260_abnormal_autophagy0.91782931
72MP0005085_abnormal_gallbladder_physiolo0.89975672
73MP0002006_tumorigenesis0.89139995
74MP0005164_abnormal_response_to0.89132390
75MP0003806_abnormal_nucleotide_metabolis0.88461658
76MP0001663_abnormal_digestive_system0.87087881
77MP0008874_decreased_physiological_sensi0.87046785
78MP0008875_abnormal_xenobiotic_pharmacok0.87020153
79MP0002254_reproductive_system_inflammat0.82985672
80MP0003252_abnormal_bile_duct0.82581725
81MP0005167_abnormal_blood-brain_barrier0.79946552
82MP0004883_abnormal_blood_vessel0.79283826
83MP0000609_abnormal_liver_physiology0.78555870
84MP0002132_abnormal_respiratory_system0.77539631
85MP0000249_abnormal_blood_vessel0.77013347
86MP0003656_abnormal_erythrocyte_physiolo0.76440717
87MP0008004_abnormal_stomach_pH0.76002640
88MP0002396_abnormal_hematopoietic_system0.73205238
89MP0009765_abnormal_xenobiotic_induced0.69002036
90MP0002332_abnormal_exercise_endurance0.67637468
91MP0003795_abnormal_bone_structure0.66018610
92MP0005319_abnormal_enzyme/_coenzyme0.65748509
93MP0001501_abnormal_sleep_pattern0.65728742
94MP0005535_abnormal_body_temperature0.64903610
95MP0003828_pulmonary_edema0.64595183
96MP0001542_abnormal_bone_strength0.62603349
97MP0002118_abnormal_lipid_homeostasis0.61734208
98MP0005023_abnormal_wound_healing0.61015017
99MP0004808_abnormal_hematopoietic_stem0.61003463
100MP0001764_abnormal_homeostasis0.60121789

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.85852984
2Orchitis (HP:0100796)4.75969444
3Retrobulbar optic neuritis (HP:0100654)4.71790108
4Optic neuritis (HP:0100653)4.71790108
5Eczematoid dermatitis (HP:0000976)4.57107133
6Systemic lupus erythematosus (HP:0002725)4.24168702
7Abnormality of macrophages (HP:0004311)3.93247068
8Recurrent abscess formation (HP:0002722)3.88423056
9Stomatitis (HP:0010280)3.86380670
10Recurrent gram-negative bacterial infections (HP:0005420)3.84956379
11Elevated erythrocyte sedimentation rate (HP:0003565)3.76854792
12Recurrent bacterial skin infections (HP:0005406)3.76419023
13Meningitis (HP:0001287)3.67799251
14Vasculitis (HP:0002633)3.59129658
15Recurrent fungal infections (HP:0002841)3.52795945
16Mediastinal lymphadenopathy (HP:0100721)3.48882620
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.45038691
18Abnormality of liposaccharide metabolism (HP:0010968)3.34707553
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.34707553
20Abnormality of glycolipid metabolism (HP:0010969)3.34707553
21Pulmonary infiltrates (HP:0002113)3.31476218
22Keratoconjunctivitis sicca (HP:0001097)3.27377275
23Complement deficiency (HP:0004431)3.25805430
24Encephalitis (HP:0002383)3.25188077
25Increased IgE level (HP:0003212)3.15131634
26Recurrent viral infections (HP:0004429)3.14553534
27Chronic mucocutaneous candidiasis (HP:0002728)3.09567106
28Recurrent cutaneous fungal infections (HP:0011370)3.09567106
29Gastrointestinal infarctions (HP:0005244)3.09020150
30T lymphocytopenia (HP:0005403)3.03456993
31Keratoconjunctivitis (HP:0001096)3.01600341
32Increased IgM level (HP:0003496)2.97540249
33Hemoptysis (HP:0002105)2.94414471
34Abnormality of T cell number (HP:0011839)2.92523136
35Obstructive lung disease (HP:0006536)2.92410078
36Chronic obstructive pulmonary disease (HP:0006510)2.92410078
37Abnormality of complement system (HP:0005339)2.90797934
38Recurrent skin infections (HP:0001581)2.90632171
39Gastrointestinal stroma tumor (HP:0100723)2.87362435
40Agammaglobulinemia (HP:0004432)2.84010403
41Purpura (HP:0000979)2.83775463
42Dysostosis multiplex (HP:0000943)2.83145271
43Panhypogammaglobulinemia (HP:0003139)2.80944764
44Pustule (HP:0200039)2.80651402
45Recurrent bronchitis (HP:0002837)2.80461242
46Colitis (HP:0002583)2.76972383
47Pulmonary embolism (HP:0002204)2.75934659
48Gingival bleeding (HP:0000225)2.68589536
49Glomerulonephritis (HP:0000099)2.68546028
50Abnormality of T cells (HP:0002843)2.62089577
51Inflammation of the large intestine (HP:0002037)2.61584828
52Spontaneous hematomas (HP:0007420)2.61542241
53Deep venous thrombosis (HP:0002625)2.60236967
54Gingivitis (HP:0000230)2.55160398
55Gastrointestinal inflammation (HP:0004386)2.55083293
56Gangrene (HP:0100758)2.54660132
57Hypergammaglobulinemia (HP:0010702)2.54005168
58Joint swelling (HP:0001386)2.51652328
59Emphysema (HP:0002097)2.50442121
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49966135
61Cellulitis (HP:0100658)2.49141633
62Increased serum ferritin (HP:0003281)2.48533234
63Arterial thrombosis (HP:0004420)2.47724547
64Epistaxis (HP:0000421)2.47058419
65Loss of speech (HP:0002371)2.46471273
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44200505
67Abnormality of polysaccharide metabolism (HP:0011012)2.44200505
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44200505
69Autoimmune hemolytic anemia (HP:0001890)2.42657213
70Prolonged bleeding time (HP:0003010)2.42608439
71Abnormality of the pleura (HP:0002103)2.40248826
72Urticaria (HP:0001025)2.38923904
73Lymphopenia (HP:0001888)2.37296216
74Autoimmune thrombocytopenia (HP:0001973)2.36699499
75Anorexia (HP:0002039)2.32962561
76Petechiae (HP:0000967)2.29082647
77Urinary glycosaminoglycan excretion (HP:0003541)2.27816178
78Mucopolysacchariduria (HP:0008155)2.27816178
79Abnormality of T cell physiology (HP:0011840)2.26680683
80Chronic otitis media (HP:0000389)2.25820326
81Joint hemorrhage (HP:0005261)2.25445117
82Increased cerebral lipofuscin (HP:0011813)2.23728876
83Leukocytosis (HP:0001974)2.22018357
84Granulocytopenia (HP:0001913)2.21682080
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.21126280
86Chest pain (HP:0100749)2.17653637
87Abnormality of iron homeostasis (HP:0011031)2.16585673
88IgG deficiency (HP:0004315)2.15749672
89Vacuolated lymphocytes (HP:0001922)2.14106877
90Hyperlipoproteinemia (HP:0010980)2.13310524
91Episodic fever (HP:0001954)2.10912436
92Acne (HP:0001061)2.09069437
93Hypochromic anemia (HP:0001931)2.08345191
94Arthralgia (HP:0002829)2.07184640
95Abnormality of B cell number (HP:0010975)2.05202641
96Abnormality of the nasal mucosa (HP:0000433)2.03138940
97Nasal polyposis (HP:0100582)1.99551410
98Restrictive lung disease (HP:0002091)1.99320535
99Amyloidosis (HP:0011034)1.98567695
100Abnormality of the pericardium (HP:0001697)1.97066803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.43649639
2RIPK43.40518216
3TYK23.11087106
4ERN12.97123628
5PRPF4B2.76219297
6IKBKE2.63580994
7MAP3K142.54623519
8TBK12.54126856
9JAK32.35921220
10TXK2.35238802
11BLK2.16990143
12JAK12.07292798
13IRAK41.98999335
14ZAP701.94883669
15FGFR41.92242150
16KIT1.89310242
17TNK21.82841336
18FES1.82381853
19CSK1.75488763
20IKBKB1.67538328
21TAOK31.64855292
22SYK1.64012801
23MAP3K111.63531152
24BTK1.56228668
25MAP2K31.53274055
26RIPK11.51744330
27MAP3K131.50429719
28TRIB31.48246162
29IRAK31.41247038
30GRK61.38948517
31SIK31.37574115
32EPHB11.33966545
33CSF1R1.33081652
34CDC42BPA1.29709033
35MATK1.28220585
36SIK21.27737820
37TAOK21.26900626
38LYN1.23330468
39ITK1.23083568
40LCK1.22004000
41HCK1.19146998
42SIK11.16923526
43BMPR21.15718711
44MAP3K31.14421957
45FGFR31.08162686
46GRK71.06179114
47JAK21.01585818
48HIPK20.99226126
49MAPK70.97085368
50TESK20.96146342
51MAP3K10.95616170
52FGR0.91334753
53TAOK10.88205322
54TEC0.87618780
55MARK30.85835150
56PRKD20.84723816
57MAPK110.84407777
58PDK10.76533128
59MAP2K60.74887282
60CHUK0.74490138
61PRKCQ0.74237234
62DDR20.74225669
63MAPK120.73720039
64IRAK10.71333648
65MARK20.69271596
66TGFBR20.68170363
67NME20.66297022
68KDR0.64246244
69CAMKK10.60842446
70DAPK20.58394606
71PDPK10.58271431
72EPHA30.58211586
73SMG10.53573265
74PIM20.53359693
75PIM10.52074123
76ADRBK20.51523582
77MAP3K70.50098810
78FYN0.48316463
79MAP2K20.47301684
80STK100.43125858
81PRKCH0.42463592
82MAPK40.41220075
83NEK90.40403603
84RPS6KC10.38626220
85RPS6KL10.38626220
86IRAK20.38118221
87MOS0.38052839
88CDK40.34253048
89MAPKAPK20.32611139
90RPS6KA60.32119090
91CAMKK20.31421210
92PTK60.30712677
93TYRO30.30208275
94ABL10.29958528
95MAPK30.29562058
96PTK2B0.29140942
97NLK0.27580929
98RPS6KA20.27228769
99DYRK1B0.26933178
100PRKG20.26307326

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.21263518
2Graft-versus-host disease_Homo sapiens_hsa053322.99244500
3Staphylococcus aureus infection_Homo sapiens_hsa051502.86547292
4Autoimmune thyroid disease_Homo sapiens_hsa053202.86202895
5Primary immunodeficiency_Homo sapiens_hsa053402.74631363
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.50179714
7Leishmaniasis_Homo sapiens_hsa051402.45516795
8Osteoclast differentiation_Homo sapiens_hsa043802.36195911
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.29758717
10Type I diabetes mellitus_Homo sapiens_hsa049402.28263281
11Asthma_Homo sapiens_hsa053102.25937915
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.25641096
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.24979701
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.17411511
15Other glycan degradation_Homo sapiens_hsa005112.04002858
16Antigen processing and presentation_Homo sapiens_hsa046121.86612096
17Measles_Homo sapiens_hsa051621.85822599
18B cell receptor signaling pathway_Homo sapiens_hsa046621.82450352
19Influenza A_Homo sapiens_hsa051641.71332404
20Complement and coagulation cascades_Homo sapiens_hsa046101.68914867
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.66686294
22Tuberculosis_Homo sapiens_hsa051521.65091117
23TNF signaling pathway_Homo sapiens_hsa046681.64330865
24Malaria_Homo sapiens_hsa051441.63798966
25Hematopoietic cell lineage_Homo sapiens_hsa046401.61711836
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.60040042
27Herpes simplex infection_Homo sapiens_hsa051681.59189457
28Rheumatoid arthritis_Homo sapiens_hsa053231.56833372
29Pertussis_Homo sapiens_hsa051331.55650965
30Viral myocarditis_Homo sapiens_hsa054161.54180249
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53773239
32African trypanosomiasis_Homo sapiens_hsa051431.46899141
33Toxoplasmosis_Homo sapiens_hsa051451.46394210
34T cell receptor signaling pathway_Homo sapiens_hsa046601.44006483
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.38927965
36Hepatitis C_Homo sapiens_hsa051601.32962071
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22366113
38Chemokine signaling pathway_Homo sapiens_hsa040621.20205604
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.15498778
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15484523
41Acute myeloid leukemia_Homo sapiens_hsa052211.12968445
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12095002
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09206435
44Lysosome_Homo sapiens_hsa041421.00144949
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97726115
46Legionellosis_Homo sapiens_hsa051340.97472313
47Prion diseases_Homo sapiens_hsa050200.96790267
48Hepatitis B_Homo sapiens_hsa051610.96772066
49Phagosome_Homo sapiens_hsa041450.87545458
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83660533
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77817104
52Salmonella infection_Homo sapiens_hsa051320.76234820
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.73657646
54Caffeine metabolism_Homo sapiens_hsa002320.73325366
55Apoptosis_Homo sapiens_hsa042100.72406890
56Shigellosis_Homo sapiens_hsa051310.71405253
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.68469384
58Prolactin signaling pathway_Homo sapiens_hsa049170.64509021
59VEGF signaling pathway_Homo sapiens_hsa043700.62485444
60Platelet activation_Homo sapiens_hsa046110.62458053
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62225705
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.59950775
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59654100
64Epstein-Barr virus infection_Homo sapiens_hsa051690.58459573
65Amoebiasis_Homo sapiens_hsa051460.57336712
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56345537
67Insulin resistance_Homo sapiens_hsa049310.49829804
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49632623
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.49292749
70Arachidonic acid metabolism_Homo sapiens_hsa005900.44214408
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.43356596
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.39869444
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39400724
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38336816
75HTLV-I infection_Homo sapiens_hsa051660.38292157
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37674627
77PPAR signaling pathway_Homo sapiens_hsa033200.36330986
78Endocytosis_Homo sapiens_hsa041440.35993923
79Retinol metabolism_Homo sapiens_hsa008300.35045312
80Phenylalanine metabolism_Homo sapiens_hsa003600.34898698
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34695493
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34448875
83Chemical carcinogenesis_Homo sapiens_hsa052040.34345523
84ABC transporters_Homo sapiens_hsa020100.34316115
85Pancreatic cancer_Homo sapiens_hsa052120.34041449
86Viral carcinogenesis_Homo sapiens_hsa052030.31336025
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.30736868
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.30267130
89Chronic myeloid leukemia_Homo sapiens_hsa052200.30112327
90Non-small cell lung cancer_Homo sapiens_hsa052230.26141998
91Type II diabetes mellitus_Homo sapiens_hsa049300.25549908
92Linoleic acid metabolism_Homo sapiens_hsa005910.25251356
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24484822
94MAPK signaling pathway_Homo sapiens_hsa040100.23359480
95Notch signaling pathway_Homo sapiens_hsa043300.23328982
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23273401
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20240990
98GnRH signaling pathway_Homo sapiens_hsa049120.19825921
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.19613068
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19587391

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