ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	acrosome reaction (GO:0007340)	7.28406338
2	sperm motility (GO:0030317)	6.92388129
3	chromosome condensation (GO:0030261)	6.85591491
4	DNA packaging (GO:0006323)	6.26838514
5	sperm capacitation (GO:0048240)	6.23796301
6	response to pheromone (GO:0019236)	6.04092985
7	fusion of sperm to egg plasma membrane (GO:0007342)	5.83067746
8	single strand break repair (GO:0000012)	5.32950169
9	calcium ion-dependent exocytosis (GO:0017156)	5.18393925
10	spermatid development (GO:0007286)	4.73968180
11	spermatid nucleus differentiation (GO:0007289)	4.65708547
12	protein polyglutamylation (GO:0018095)	4.57983153
13	rRNA methylation (GO:0031167)	4.51619633
14	microtubule severing (GO:0051013)	4.41584709
15	plasma membrane fusion (GO:0045026)	4.35137300
16	chromatin silencing (GO:0006342)	4.32252655
17	response to acidic pH (GO:0010447)	4.28281636
18	sexual reproduction (GO:0019953)	4.21739286
19	microtubule depolymerization (GO:0007019)	4.14037763
20	negative regulation of inclusion body assembly (GO:0090084)	4.09978777
21	positive regulation of Rab GTPase activity (GO:0032851)	4.00337884
22	regulation of Rab GTPase activity (GO:0032313)	4.00337884
23	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.97683023
24	regulation of somitogenesis (GO:0014807)	3.94766872
25	regulation of ARF GTPase activity (GO:0032312)	3.91845438
26	pattern specification involved in kidney development (GO:0061004)	3.86352585
27	sperm-egg recognition (GO:0035036)	3.80023959
28	microtubule polymerization or depolymerization (GO:0031109)	3.73000588
29	mitotic G1 DNA damage checkpoint (GO:0031571)	3.69828190
30	protein-DNA complex disassembly (GO:0032986)	3.69585719
31	nucleosome disassembly (GO:0006337)	3.69585719
32	regulation of transcription involved in cell fate commitment (GO:0060850)	3.66734372
33	receptor recycling (GO:0001881)	3.59659020
34	reproduction (GO:0000003)	3.58261615
35	binding of sperm to zona pellucida (GO:0007339)	3.57083670
36	rRNA modification (GO:0000154)	3.55415870
37	multicellular organism reproduction (GO:0032504)	3.54638507
38	negative regulation of Rho protein signal transduction (GO:0035024)	3.50769014
39	phosphatidylethanolamine metabolic process (GO:0046337)	3.49266345
40	spermatogenesis (GO:0007283)	3.39544989
41	male gamete generation (GO:0048232)	3.38076298
42	cellular response to pH (GO:0071467)	3.36514004
43	tooth mineralization (GO:0034505)	3.35206362
44	G1 DNA damage checkpoint (GO:0044783)	3.34146352
45	positive regulation of synapse maturation (GO:0090129)	3.33999867
46	motile cilium assembly (GO:0044458)	3.33254741
47	mitotic G1/S transition checkpoint (GO:0044819)	3.30758575
48	endothelial cell chemotaxis (GO:0035767)	3.29701968
49	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.29188170
50	glutamate secretion (GO:0014047)	3.28048145
51	regulation of inclusion body assembly (GO:0090083)	3.24585578
52	protein targeting to Golgi (GO:0000042)	3.21705787
53	cell-cell junction maintenance (GO:0045217)	3.21466126
54	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.20049982
55	cranial nerve morphogenesis (GO:0021602)	3.18923647
56	neuronal ion channel clustering (GO:0045161)	3.17884188
57	positive regulation of myotube differentiation (GO:0010831)	3.16687880
58	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.15426641
59	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.14061522
60	cell-cell recognition (GO:0009988)	3.11793978
61	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.10514398
62	musculoskeletal movement (GO:0050881)	3.10429688
63	multicellular organismal movement (GO:0050879)	3.10429688
64	RNA destabilization (GO:0050779)	3.09423600
65	intracellular estrogen receptor signaling pathway (GO:0030520)	3.08810356
66	urinary tract smooth muscle contraction (GO:0014848)	3.06745042
67	gamete generation (GO:0007276)	3.04684449
68	cerebral cortex neuron differentiation (GO:0021895)	3.03957541
69	establishment of protein localization to Golgi (GO:0072600)	3.02524355
70	sodium ion export (GO:0071436)	2.99664152
71	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.98161107
72	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.96925073
73	negative regulation of gene expression, epigenetic (GO:0045814)	2.89932489
74	histone H4 deacetylation (GO:0070933)	2.86272122
75	histone H3 deacetylation (GO:0070932)	2.84140028
76	synaptic vesicle exocytosis (GO:0016079)	2.77709542
77	axonemal dynein complex assembly (GO:0070286)	2.76067950
78	locomotory exploration behavior (GO:0035641)	2.74644672
79	coenzyme catabolic process (GO:0009109)	2.74324838
80	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.73934998
81	cochlea morphogenesis (GO:0090103)	2.71648118
82	postsynaptic membrane organization (GO:0001941)	2.71053295
83	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.68984686
84	regulation of histone H3-K27 methylation (GO:0061085)	2.67234953
85	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	2.66077988
86	establishment of apical/basal cell polarity (GO:0035089)	2.65126563
87	negative regulation of histone methylation (GO:0031061)	2.64195438
88	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.63934079
89	positive regulation of histone deacetylation (GO:0031065)	2.63556443
90	negative regulation of granulocyte differentiation (GO:0030853)	2.63277983
91	germ cell development (GO:0007281)	2.62522532
92	negative regulation of catenin import into nucleus (GO:0035414)	2.59390066
93	single fertilization (GO:0007338)	2.58302219
94	negative regulation of cell size (GO:0045792)	2.57338624
95	neuromuscular process controlling balance (GO:0050885)	2.55085416
96	regulation of synapse maturation (GO:0090128)	2.54314435
97	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.51428286
98	nucleus organization (GO:0006997)	2.50185064
99	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.50025933
100	semaphorin-plexin signaling pathway (GO:0071526)	2.48856939

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.82654665
2	LXR_22292898_ChIP-Seq_THP-1_Human	3.33405923
3	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.97451594
4	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.81430216
5	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.79572329
6	EZH2_22144423_ChIP-Seq_EOC_Human	2.78101006
7	P68_20966046_ChIP-Seq_HELA_Human	2.57717193
8	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.54489254
9	CTCF_27219007_Chip-Seq_Bcells_Human	2.48771136
10	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.23949281
11	SMC4_20622854_ChIP-Seq_HELA_Human	2.21233322
12	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.18276789
13	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.13256809
14	KDM2B_26808549_Chip-Seq_K562_Human	2.09026130
15	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	2.00315925
16	VDR_21846776_ChIP-Seq_THP-1_Human	2.00032579
17	KDM2B_26808549_Chip-Seq_DND41_Human	1.96791235
18	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.94311480
19	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.91774034
20	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.85085148
21	DROSHA_22980978_ChIP-Seq_HELA_Human	1.81853583
22	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.80664071
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.77684543
24	E2F1_20622854_ChIP-Seq_HELA_Human	1.76753290
25	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.76050861
26	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.75020806
27	BCL6_27268052_Chip-Seq_Bcells_Human	1.71778701
28	BCOR_27268052_Chip-Seq_Bcells_Human	1.70256775
29	RACK7_27058665_Chip-Seq_MCF-7_Human	1.69903689
30	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.68309306
31	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.66582946
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.65827423
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.65040660
34	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.64599791
35	PHF8_20622854_ChIP-Seq_HELA_Human	1.64077519
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.63076916
37	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.62585646
38	SA1_27219007_Chip-Seq_Bcells_Human	1.62413991
39	TP63_22573176_ChIP-Seq_HFKS_Human	1.57970596
40	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.57670261
41	TCF7_22412390_ChIP-Seq_EML_Mouse	1.56112356
42	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.55754987
43	MYC_22102868_ChIP-Seq_BL_Human	1.53554286
44	CTCF_20526341_ChIP-Seq_ESCs_Human	1.53469129
45	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.51538646
46	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.51198566
47	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.48567827
48	TP53_22127205_ChIP-Seq_IMR90_Human	1.48039578
49	CREB1_26743006_Chip-Seq_LNCaP_Human	1.44926416
50	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.44233472
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.42279698
52	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.42147870
53	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.40846802
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.40752359
55	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.40656632
56	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.38239456
57	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.37723572
58	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.35604375
59	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.33347115
60	OCT4_19829295_ChIP-Seq_ESCs_Human	1.33118786
61	ERA_21632823_ChIP-Seq_H3396_Human	1.29306365
62	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.28890062
63	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.26581117
64	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.26127371
65	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.24851578
66	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.24851578
67	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.24554980
68	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.21822782
69	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.21536271
70	CTCF_21964334_Chip-Seq_Bcells_Human	1.19922744
71	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19715832
72	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.19609020
73	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.19040329
74	MAF_26560356_Chip-Seq_TH2_Human	1.16558999
75	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.16508495
76	RAC3_21632823_ChIP-Seq_H3396_Human	1.15922401
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.15311316
78	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.14800500
79	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.13560526
80	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.13250321
81	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.12642250
82	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.12031664
83	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.11443960
84	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.10688137
85	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.10045100
86	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.09718582
87	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.06990557
88	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.06854380
89	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.05519020
90	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.04377537
91	KLF4_19829295_ChIP-Seq_ESCs_Human	1.03676374
92	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.03170677
93	P300_27268052_Chip-Seq_Bcells_Human	1.01261327
94	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00453987
95	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.00169802
96	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.99954323
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99831809
98	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.99584874
99	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.99361058
100	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.99219291

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	6.74521400
2	MP0004859_abnormal_synaptic_plasticity	4.03671068
3	MP0001348_abnormal_lacrimal_gland	3.67440601
4	MP0005377_hearing/vestibular/ear_phenot	3.66159802
5	MP0003878_abnormal_ear_physiology	3.66159802
6	MP0005670_abnormal_white_adipose	3.47258058
7	MP0000678_abnormal_parathyroid_gland	3.41152824
8	MP0005423_abnormal_somatic_nervous	3.40908609
9	MP0002249_abnormal_larynx_morphology	2.53052847
10	MP0005451_abnormal_body_composition	2.48011775
11	MP0003698_abnormal_male_reproductive	2.36272796
12	MP0005409_darkened_coat_color	2.25307494
13	MP0003705_abnormal_hypodermis_morpholog	2.23282043
14	MP0003879_abnormal_hair_cell	2.22396041
15	MP0001968_abnormal_touch/_nociception	1.98538607
16	MP0000751_myopathy	1.91217323
17	MP0003635_abnormal_synaptic_transmissio	1.83967252
18	MP0001929_abnormal_gametogenesis	1.68199002
19	MP0009780_abnormal_chondrocyte_physiolo	1.64839584
20	MP0001188_hyperpigmentation	1.63562378
21	MP0003123_paternal_imprinting	1.62949840
22	MP0002733_abnormal_thermal_nociception	1.54274197
23	MP0008569_lethality_at_weaning	1.54238394
24	MP0001486_abnormal_startle_reflex	1.52137968
25	MP0004270_analgesia	1.52114160
26	MP0009379_abnormal_foot_pigmentation	1.49989257
27	MP0003646_muscle_fatigue	1.48965388
28	MP0009053_abnormal_anal_canal	1.43895138
29	MP0005623_abnormal_meninges_morphology	1.42387875
30	MP0002161_abnormal_fertility/fecundity	1.41779182
31	MP0002735_abnormal_chemical_nociception	1.39164275
32	MP0002064_seizures	1.33411157
33	MP0000534_abnormal_ureter_morphology	1.31366575
34	MP0002089_abnormal_postnatal_growth/wei	1.31092827
35	MP0002063_abnormal_learning/memory/cond	1.23938553
36	MP0000955_abnormal_spinal_cord	1.22945685
37	MP0000750_abnormal_muscle_regeneration	1.21360483
38	MP0001970_abnormal_pain_threshold	1.20481796
39	MP0003329_amyloid_beta_deposits	1.19918657
40	MP0002734_abnormal_mechanical_nocicepti	1.19642212
41	MP0002572_abnormal_emotion/affect_behav	1.17035553
42	MP0000681_abnormal_thyroid_gland	1.13787749
43	MP0000003_abnormal_adipose_tissue	1.13176645
44	MP0004510_myositis	1.12932640
45	MP0009278_abnormal_bone_marrow	1.09619402
46	MP0000049_abnormal_middle_ear	1.09513430
47	MP0009745_abnormal_behavioral_response	1.09394833
48	MP0004858_abnormal_nervous_system	1.09346431
49	MP0002822_catalepsy	1.08886271
50	MP0002234_abnormal_pharynx_morphology	1.06040179
51	MP0000733_abnormal_muscle_development	1.03622469
52	MP0005379_endocrine/exocrine_gland_phen	1.03328874
53	MP0002272_abnormal_nervous_system	1.03269911
54	MP0003942_abnormal_urinary_system	1.03137426
55	MP0001849_ear_inflammation	1.02626128
56	MP0004233_abnormal_muscle_weight	1.01931514
57	MP0001905_abnormal_dopamine_level	1.00935141
58	MP0005666_abnormal_adipose_tissue	0.99822046
59	MP0000759_abnormal_skeletal_muscle	0.97910836
60	MP0005375_adipose_tissue_phenotype	0.97898226
61	MP0001485_abnormal_pinna_reflex	0.95110949
62	MP0001765_abnormal_ion_homeostasis	0.92335952
63	MP0001270_distended_abdomen	0.89580916
64	MP0000026_abnormal_inner_ear	0.87871999
65	MP0006292_abnormal_olfactory_placode	0.87243701
66	MP0001963_abnormal_hearing_physiology	0.86995181
67	MP0003787_abnormal_imprinting	0.86819332
68	MP0003283_abnormal_digestive_organ	0.86424505
69	MP0001299_abnormal_eye_distance/	0.85719864
70	MP0004811_abnormal_neuron_physiology	0.85413301
71	MP0002557_abnormal_social/conspecific_i	0.84292026
72	MP0003861_abnormal_nervous_system	0.83677096
73	MP0001440_abnormal_grooming_behavior	0.83197803
74	MP0003136_yellow_coat_color	0.81588400
75	MP0004742_abnormal_vestibular_system	0.79588445
76	MP0009046_muscle_twitch	0.79507139
77	MP0004087_abnormal_muscle_fiber	0.79059285
78	MP0002067_abnormal_sensory_capabilities	0.78645418
79	MP0002882_abnormal_neuron_morphology	0.78254957
80	MP0003172_abnormal_lysosome_physiology	0.78204761
81	MP0002210_abnormal_sex_determination	0.76124657
82	MP0000749_muscle_degeneration	0.74008696
83	MP0004130_abnormal_muscle_cell	0.73872705
84	MP0003385_abnormal_body_wall	0.71760777
85	MP0001502_abnormal_circadian_rhythm	0.70460406
86	MP0002152_abnormal_brain_morphology	0.69763796
87	MP0003453_abnormal_keratinocyte_physiol	0.69105483
88	MP0005503_abnormal_tendon_morphology	0.65094930
89	MP0005248_abnormal_Harderian_gland	0.64698106
90	MP0005257_abnormal_intraocular_pressure	0.63070021
91	MP0000566_synostosis	0.62210346
92	MP0002066_abnormal_motor_capabilities/c	0.61994849
93	MP0002229_neurodegeneration	0.58579634
94	MP0003115_abnormal_respiratory_system	0.58337853
95	MP0001986_abnormal_taste_sensitivity	0.57505604
96	MP0000778_abnormal_nervous_system	0.54638580
97	MP0001145_abnormal_male_reproductive	0.54463951
98	MP0002932_abnormal_joint_morphology	0.53784325
99	MP0002116_abnormal_craniofacial_bone	0.53700587
100	MP0009115_abnormal_fat_cell	0.51526691

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	4.61207602
2	Asymmetric septal hypertrophy (HP:0001670)	4.49355343
3	Turricephaly (HP:0000262)	3.73070478
4	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	3.72154326
5	Bony spicule pigmentary retinopathy (HP:0007737)	3.55305874
6	Obstructive sleep apnea (HP:0002870)	3.44836746
7	Hyperthyroidism (HP:0000836)	3.44824026
8	Resting tremor (HP:0002322)	3.34928083
9	Bell-shaped thorax (HP:0001591)	3.25989803
10	Impulsivity (HP:0100710)	3.24709412
11	Myokymia (HP:0002411)	3.09480047
12	Annular pancreas (HP:0001734)	2.85639499
13	Stridor (HP:0010307)	2.77851764
14	Abnormality of the aortic arch (HP:0012303)	2.74054411
15	Nasal polyposis (HP:0100582)	2.66831615
16	Hyperacusis (HP:0010780)	2.64146192
17	Ulnar bowing (HP:0003031)	2.56046659
18	Male infertility (HP:0003251)	2.52895995
19	Hyperkalemia (HP:0002153)	2.52682968
20	Atelectasis (HP:0100750)	2.47164555
21	Postural instability (HP:0002172)	2.46339688
22	Attenuation of retinal blood vessels (HP:0007843)	2.40041908
23	Hypoplastic ischia (HP:0003175)	2.39856492
24	Unilateral renal agenesis (HP:0000122)	2.37521737
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.37396012
26	Renovascular hypertension (HP:0100817)	2.37291166
27	Truncus arteriosus (HP:0001660)	2.37280407
28	Distal lower limb muscle weakness (HP:0009053)	2.36759133
29	Easy fatigability (HP:0003388)	2.29647656
30	Exercise-induced myalgia (HP:0003738)	2.27807271
31	Myotonia (HP:0002486)	2.27712341
32	Hypoplasia of the thymus (HP:0000778)	2.27260110
33	Abnormality of the nasal mucosa (HP:0000433)	2.26584580
34	Infertility (HP:0000789)	2.24559190
35	Bowel incontinence (HP:0002607)	2.22195571
36	Stereotypic behavior (HP:0000733)	2.21962433
37	Abnormality of the costochondral junction (HP:0000919)	2.21303120
38	Congenital malformation of the right heart (HP:0011723)	2.20258920
39	Double outlet right ventricle (HP:0001719)	2.20258920
40	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.10925318
41	Diplopia (HP:0000651)	2.10779952
42	Abnormality of binocular vision (HP:0011514)	2.10779952
43	Epiphyseal dysplasia (HP:0002656)	2.08632615
44	Obsessive-compulsive behavior (HP:0000722)	2.07721035
45	Progressive cerebellar ataxia (HP:0002073)	2.06773194
46	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.06692748
47	Achilles tendon contracture (HP:0001771)	2.06113617
48	Deep palmar crease (HP:0006191)	2.05149800
49	Abnormal large intestine physiology (HP:0012700)	2.02302868
50	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.01528081
51	Cerebral hypomyelination (HP:0006808)	1.99963515
52	Amblyopia (HP:0000646)	1.99328628
53	Visual hallucinations (HP:0002367)	1.97050878
54	Abnormality of the ischium (HP:0003174)	1.96285478
55	Abnormality of the parietal bone (HP:0002696)	1.96225558
56	Abnormal ventriculo-arterial connection (HP:0011563)	1.92932229
57	Transposition of the great arteries (HP:0001669)	1.92932229
58	Abnormal connection of the cardiac segments (HP:0011545)	1.92932229
59	Broad face (HP:0000283)	1.92854427
60	Spinal rigidity (HP:0003306)	1.92783584
61	Distal upper limb amyotrophy (HP:0007149)	1.91321926
62	Upper limb amyotrophy (HP:0009129)	1.91321926
63	Myopathic facies (HP:0002058)	1.91296933
64	Flattened epiphyses (HP:0003071)	1.91132218
65	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.90436999
66	Absent epiphyses (HP:0010577)	1.90436999
67	Subaortic stenosis (HP:0001682)	1.88871322
68	Abnormality of the left ventricular outflow tract (HP:0011103)	1.88871322
69	Distal lower limb amyotrophy (HP:0008944)	1.81635676
70	Difficulty climbing stairs (HP:0003551)	1.80682066
71	Ventricular tachycardia (HP:0004756)	1.77065106
72	Fatigable weakness (HP:0003473)	1.76858058
73	Abnormality of the neuromuscular junction (HP:0003398)	1.76858058
74	Abnormality of the Achilles tendon (HP:0005109)	1.75656596
75	Insomnia (HP:0100785)	1.75175132
76	Renal dysplasia (HP:0000110)	1.73000309
77	Urethral obstruction (HP:0000796)	1.70715379
78	Enlarged epiphyses (HP:0010580)	1.69405901
79	Acanthosis nigricans (HP:0000956)	1.67698964
80	Self-mutilation (HP:0000742)	1.67649083
81	Supernumerary nipples (HP:0002558)	1.67337152
82	Shallow orbits (HP:0000586)	1.67174056
83	Fetal akinesia sequence (HP:0001989)	1.66975690
84	Peripheral hypomyelination (HP:0007182)	1.66114397
85	Bradycardia (HP:0001662)	1.65955966
86	Muscle stiffness (HP:0003552)	1.64790702
87	Short 4th metacarpal (HP:0010044)	1.63062928
88	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.63062928
89	Patellar dislocation (HP:0002999)	1.62507047
90	Hypoparathyroidism (HP:0000829)	1.61808016
91	Aplasia involving bones of the upper limbs (HP:0009823)	1.61422861
92	Aplasia of the phalanges of the hand (HP:0009802)	1.61422861
93	Aplasia involving bones of the extremities (HP:0009825)	1.61422861
94	High anterior hairline (HP:0009890)	1.60833277
95	Thin bony cortex (HP:0002753)	1.60521305
96	Lower limb amyotrophy (HP:0007210)	1.59307116
97	Genetic anticipation (HP:0003743)	1.59245009
98	Progressive sensorineural hearing impairment (HP:0000408)	1.57933040
99	Sudden death (HP:0001699)	1.57914621
100	Poikiloderma (HP:0001029)	1.57861459

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK1	3.64132066
2	DDR2	3.37904826
3	PLK4	3.14962277
4	PRKD3	2.78773690
5	TRIB3	2.65725799
6	ICK	2.52384335
7	SIK1	2.35113336
8	SIK2	2.24358178
9	EEF2K	2.22356720
10	MAP3K9	2.14106224
11	SMG1	2.02564483
12	STK38	2.02552942
13	TYRO3	1.97406733
14	CDK12	1.96893737
15	MAPK15	1.95525330
16	MARK2	1.89364972
17	PRPF4B	1.69882825
18	LATS2	1.68465525
19	ARAF	1.62897869
20	CAMK1G	1.54186974
21	MAP3K11	1.53799690
22	PDPK1	1.43727535
23	MST1R	1.39522863
24	MTOR	1.33751253
25	RPS6KA2	1.31385107
26	UHMK1	1.31005428
27	ERN1	1.29477602
28	MAP3K13	1.29344113
29	CAMK1D	1.24671504
30	WNK1	1.16431207
31	PRKD2	1.11072435
32	PRKCH	1.10841340
33	DYRK1B	1.09633143
34	RIPK1	1.08968701
35	MAP3K1	1.05693007
36	NME2	1.05272832
37	CDK7	1.04455272
38	NTRK3	1.03873726
39	TTN	1.03401969
40	BRAF	1.03089589
41	PDK1	1.02762536
42	PLK2	0.98726190
43	WNK4	0.94107924
44	CAMK1	0.92905645
45	KSR2	0.84960110
46	MARK1	0.84546557
47	MAP3K7	0.83456473
48	MAPK12	0.82638347
49	PRKG2	0.75895212
50	MAP3K10	0.75041866
51	CDK4	0.73809064
52	CDK11A	0.71323811
53	RPS6KL1	0.69740750
54	RPS6KC1	0.69740750
55	DMPK	0.66217902
56	MAPK11	0.65541083
57	IRAK3	0.64578893
58	NTRK1	0.64010310
59	PAK6	0.63525808
60	PTK2B	0.60226512
61	CAMKK1	0.60152819
62	AURKA	0.59833116
63	PNCK	0.59167045
64	MAPK8	0.58892700
65	BRD4	0.58419113
66	MAP2K2	0.58404562
67	HIPK2	0.57446641
68	RPS6KA6	0.56611900
69	PDGFRA	0.56602942
70	RPS6KA1	0.56115277
71	PINK1	0.56104175
72	GSK3B	0.55437578
73	PHKG2	0.55433503
74	PHKG1	0.55433503
75	SGK223	0.55191141
76	SGK494	0.55191141
77	TNK2	0.54746833
78	IRAK2	0.54465792
79	EPHA2	0.53737660
80	MOS	0.53551763
81	INSRR	0.53042770
82	CDK2	0.52506311
83	SGK3	0.51960833
84	CAMK4	0.51907616
85	BMX	0.51657841
86	TAF1	0.51559603
87	CDK8	0.51534668
88	PRKCZ	0.50232538
89	CDK5	0.50172502
90	CDK14	0.48540015
91	RIPK4	0.46495116
92	MAPK10	0.45824906
93	MINK1	0.45657937
94	CDK15	0.45655765
95	PRKCG	0.45224498
96	CDC42BPA	0.44997099
97	NTRK2	0.44578036
98	STK38L	0.44108283
99	PIM2	0.43441718
100	MAPKAPK5	0.42744828

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.65600556
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.40925725
3	Notch signaling pathway_Homo sapiens_hsa04330	2.01207146
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.92582762
5	Long-term potentiation_Homo sapiens_hsa04720	1.89350388
6	Olfactory transduction_Homo sapiens_hsa04740	1.86206792
7	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.86204668
8	VEGF signaling pathway_Homo sapiens_hsa04370	1.62995612
9	Sulfur relay system_Homo sapiens_hsa04122	1.62358597
10	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.61644068
11	Insulin secretion_Homo sapiens_hsa04911	1.60444222
12	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.58250979
13	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	1.48588706
14	Circadian entrainment_Homo sapiens_hsa04713	1.43713734
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41940100
16	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.40668981
17	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.39875822
18	Nicotine addiction_Homo sapiens_hsa05033	1.38401228
19	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.37079994
20	Type II diabetes mellitus_Homo sapiens_hsa04930	1.35352250
21	Gastric acid secretion_Homo sapiens_hsa04971	1.35208913
22	Estrogen signaling pathway_Homo sapiens_hsa04915	1.33801232
23	Glioma_Homo sapiens_hsa05214	1.33559773
24	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.31678341
25	Cholinergic synapse_Homo sapiens_hsa04725	1.30500761
26	Melanogenesis_Homo sapiens_hsa04916	1.29778570
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.27161423
28	Endocytosis_Homo sapiens_hsa04144	1.24116986
29	Morphine addiction_Homo sapiens_hsa05032	1.22850239
30	Calcium signaling pathway_Homo sapiens_hsa04020	1.20762452
31	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.20128232
32	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.20045250
33	cAMP signaling pathway_Homo sapiens_hsa04024	1.18889107
34	MAPK signaling pathway_Homo sapiens_hsa04010	1.18849312
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.18553705
36	Acute myeloid leukemia_Homo sapiens_hsa05221	1.13689931
37	Cocaine addiction_Homo sapiens_hsa05030	1.09585010
38	Salivary secretion_Homo sapiens_hsa04970	1.08903516
39	Taste transduction_Homo sapiens_hsa04742	1.08784749
40	GABAergic synapse_Homo sapiens_hsa04727	1.08637758
41	Axon guidance_Homo sapiens_hsa04360	1.06928264
42	Basal cell carcinoma_Homo sapiens_hsa05217	1.06751714
43	Amphetamine addiction_Homo sapiens_hsa05031	1.05847125
44	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.05482852
45	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.04235662
46	Bladder cancer_Homo sapiens_hsa05219	1.02916584
47	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.02806264
48	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.02541194
49	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.02073637
50	Non-small cell lung cancer_Homo sapiens_hsa05223	1.01006949
51	Cardiac muscle contraction_Homo sapiens_hsa04260	1.00711770
52	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.00414219
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.99949583
54	Dopaminergic synapse_Homo sapiens_hsa04728	0.99495481
55	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.97581385
56	Gap junction_Homo sapiens_hsa04540	0.96172253
57	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.95274448
58	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.93812957
59	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.93105017
60	Lysine degradation_Homo sapiens_hsa00310	0.92339134
61	mTOR signaling pathway_Homo sapiens_hsa04150	0.90506118
62	ErbB signaling pathway_Homo sapiens_hsa04012	0.89249019
63	Endometrial cancer_Homo sapiens_hsa05213	0.87916455
64	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.87440042
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.86563543
66	AMPK signaling pathway_Homo sapiens_hsa04152	0.85703088
67	Thyroid cancer_Homo sapiens_hsa05216	0.85631516
68	Insulin signaling pathway_Homo sapiens_hsa04910	0.85169948
69	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.84774364
70	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.84745803
71	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.83524479
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.82202127
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.82058255
74	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.81334755
75	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.80532596
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.78605241
77	Prion diseases_Homo sapiens_hsa05020	0.75338864
78	Focal adhesion_Homo sapiens_hsa04510	0.75203154
79	Wnt signaling pathway_Homo sapiens_hsa04310	0.74850374
80	Renin secretion_Homo sapiens_hsa04924	0.73904750
81	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.73117500
82	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.72283685
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69264608
84	ECM-receptor interaction_Homo sapiens_hsa04512	0.68385832
85	Tight junction_Homo sapiens_hsa04530	0.68018365
86	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.67584759
87	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.64155918
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.63374529
89	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.62334659
90	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.62214277
91	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59649970
92	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.57800448
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.57534259
94	Bile secretion_Homo sapiens_hsa04976	0.57446034
95	Insulin resistance_Homo sapiens_hsa04931	0.57361163
96	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56889301
97	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.54986038
98	Oocyte meiosis_Homo sapiens_hsa04114	0.53113623
99	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.50591351
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50395524

C19ORF68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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