C19ORF71

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)7.02433540
2melanin metabolic process (GO:0006582)6.58599390
3secondary metabolite biosynthetic process (GO:0044550)5.41046032
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34689839
5mannose metabolic process (GO:0006013)4.33761550
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.32482253
7negative regulation of erythrocyte differentiation (GO:0045647)4.23769117
8antigen processing and presentation via MHC class Ib (GO:0002475)4.07421245
9antigen processing and presentation of endogenous antigen (GO:0019883)3.94481443
10response to peptidoglycan (GO:0032494)3.71061296
11positive regulation of gamma-delta T cell activation (GO:0046645)3.60706137
12melanocyte differentiation (GO:0030318)3.58257686
13pigment cell differentiation (GO:0050931)3.50024930
14macrophage activation involved in immune response (GO:0002281)3.48201374
15regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.42127475
16protein localization to endosome (GO:0036010)3.35632319
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33640015
18response to muramyl dipeptide (GO:0032495)3.29978719
19regulation of T-helper 2 cell differentiation (GO:0045628)3.28005167
20positive regulation by symbiont of host defense response (GO:0052509)3.22889237
21modulation by symbiont of host defense response (GO:0052031)3.22889237
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22889237
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22889237
24positive regulation by organism of defense response of other organism involved in symbiotic interact3.22889237
25modulation by symbiont of host immune response (GO:0052553)3.22889237
26cellular extravasation (GO:0045123)3.20258926
27amino sugar catabolic process (GO:0046348)3.19392840
28response to laminar fluid shear stress (GO:0034616)3.15612395
29cellular response to thyroid hormone stimulus (GO:0097067)3.06847899
30regulation of leukocyte degranulation (GO:0043300)3.04764021
31negative regulation of cell killing (GO:0031342)3.02601299
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02601299
33positive thymic T cell selection (GO:0045059)3.01309642
34regulation of interferon-beta biosynthetic process (GO:0045357)2.98604269
35lipopolysaccharide-mediated signaling pathway (GO:0031663)2.96332221
36germinal center formation (GO:0002467)2.96031774
37NIK/NF-kappaB signaling (GO:0038061)2.95415424
38positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.95072854
39neutrophil activation involved in immune response (GO:0002283)2.93528698
40glycosphingolipid catabolic process (GO:0046479)2.92527418
41regulation of mast cell degranulation (GO:0043304)2.92335054
42barbed-end actin filament capping (GO:0051016)2.90573179
43regulation of gamma-delta T cell activation (GO:0046643)2.87996374
44positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.87626072
45negative regulation of interleukin-12 production (GO:0032695)2.84683533
46N-acetylneuraminate metabolic process (GO:0006054)2.83667515
47positive regulation of antigen processing and presentation (GO:0002579)2.81193501
48thymic T cell selection (GO:0045061)2.77242763
49response to thyroid hormone (GO:0097066)2.74497998
50regulation of myeloid leukocyte mediated immunity (GO:0002886)2.73243753
51regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73039732
52detection of molecule of bacterial origin (GO:0032490)2.70107063
53pinocytosis (GO:0006907)2.67645748
54detection of other organism (GO:0098543)2.67248863
55regulation of gamma-delta T cell differentiation (GO:0045586)2.65051011
56regulation of ARF GTPase activity (GO:0032312)2.64200433
57epithelial cell differentiation involved in prostate gland development (GO:0060742)2.62975011
58negative regulation of granulocyte differentiation (GO:0030853)2.62253787
59regulation of mast cell activation involved in immune response (GO:0033006)2.60767036
60positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59010772
61detection of bacterium (GO:0016045)2.58198757
62regulation of early endosome to late endosome transport (GO:2000641)2.57958664
63glycolipid catabolic process (GO:0019377)2.54934686
64detection of external biotic stimulus (GO:0098581)2.54385531
65myeloid cell activation involved in immune response (GO:0002275)2.52670902
66basement membrane organization (GO:0071711)2.49333455
67positive regulation of mast cell activation (GO:0033005)2.48065163
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47877700
69positive regulation of Cdc42 GTPase activity (GO:0043089)2.47130656
70leukocyte aggregation (GO:0070486)2.47032800
71modulation by symbiont of host cellular process (GO:0044068)2.46941088
72positive regulation of leukocyte degranulation (GO:0043302)2.43779742
73T cell selection (GO:0045058)2.43514073
74semaphorin-plexin signaling pathway (GO:0071526)2.43154019
75positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41987948
76regulation of antigen processing and presentation (GO:0002577)2.41376892
77activation of JUN kinase activity (GO:0007257)2.39068891
78positive regulation of type 2 immune response (GO:0002830)2.38688456
79regulation of monocyte differentiation (GO:0045655)2.37502314
80regulation of integrin activation (GO:0033623)2.35817602
81regulation of regulated secretory pathway (GO:1903305)2.35757010
82positive regulation of receptor recycling (GO:0001921)2.35390611
83negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33237591
84peptide catabolic process (GO:0043171)2.32139588
85regulation of type 2 immune response (GO:0002828)2.31959621
86stress fiber assembly (GO:0043149)2.31938945
87osteoclast differentiation (GO:0030316)2.31515694
88myeloid dendritic cell differentiation (GO:0043011)2.30319099
89apoptotic cell clearance (GO:0043277)2.30046767
90positive regulation of histone deacetylation (GO:0031065)2.28976975
91regulation of cholesterol storage (GO:0010885)2.27233288
92negative regulation of tumor necrosis factor production (GO:0032720)2.27094506
93megakaryocyte development (GO:0035855)2.24809059
94regulation of histone H3-K27 methylation (GO:0061085)2.23770469
95modulation by virus of host process (GO:0019054)2.23769690
96positive regulation of cellular amide metabolic process (GO:0034250)2.22264705
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.21923035
98negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.21760536
99positive regulation of mast cell activation involved in immune response (GO:0033008)2.21444854
100positive regulation of mast cell degranulation (GO:0043306)2.21444854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.24500752
2LXR_22292898_ChIP-Seq_THP-1_Human2.83949772
3KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73976755
4MYC_22102868_ChIP-Seq_BL_Human2.73547007
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.72205197
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.52866006
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50509418
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.45381983
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.36019228
10KDM2B_26808549_Chip-Seq_DND41_Human2.27670337
11TCF7_22412390_ChIP-Seq_EML_Mouse2.26168278
12VDR_24763502_ChIP-Seq_THP-1_Human2.22645829
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16961565
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08254034
15TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06610634
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.06476814
17RACK7_27058665_Chip-Seq_MCF-7_Human2.03400054
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.02931463
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91057569
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.89841905
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89020506
22MAF_26560356_Chip-Seq_TH1_Human1.87322899
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80449718
24E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78503428
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78363964
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78247370
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77709555
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.76527501
29KDM2B_26808549_Chip-Seq_K562_Human1.75549386
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.72327998
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70554587
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69879697
33UTX_26944678_Chip-Seq_JUKART_Human1.68011458
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.66899669
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64982887
36P68_20966046_ChIP-Seq_HELA_Human1.64030361
37* MAF_26560356_Chip-Seq_TH2_Human1.63885726
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.63878118
39KDM2B_26808549_Chip-Seq_JURKAT_Human1.60689289
40SCL_19346495_ChIP-Seq_HPC-7_Human1.59093997
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.58262807
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54119251
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52956692
44SPI1_23127762_ChIP-Seq_K562_Human1.51119816
45SMC4_20622854_ChIP-Seq_HELA_Human1.49559309
46GATA1_22025678_ChIP-Seq_K562_Human1.46925581
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.45975405
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.45406692
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45240681
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44046218
51EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43571382
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42532532
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.42434628
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41096043
55BCOR_27268052_Chip-Seq_Bcells_Human1.38881779
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38600582
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38460631
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.37601689
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37376727
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37036156
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36361214
62NCOR1_26117541_ChIP-Seq_K562_Human1.34715402
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34670120
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34357627
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33230330
66BCL6_27268052_Chip-Seq_Bcells_Human1.28761615
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23848600
68SPI1_23547873_ChIP-Seq_NB4_Human1.22272714
69GATA1_19941826_ChIP-Seq_K562_Human1.21775672
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.21654193
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20431017
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20264498
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20011493
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18100384
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17988614
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16566191
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.16075505
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12123895
79TP53_22127205_ChIP-Seq_IMR90_Human1.10315715
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09756786
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.09190304
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09010975
83RUNX_20019798_ChIP-Seq_JUKART_Human1.07520794
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06436856
85ZNF263_19887448_ChIP-Seq_K562_Human1.06307286
86SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06156915
87CREB1_26743006_Chip-Seq_LNCaP_Human1.06132642
88ATF3_27146783_Chip-Seq_COLON_Human1.04657637
89MYB_26560356_Chip-Seq_TH1_Human1.04376260
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03869498
91DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03751283
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01445359
93TP63_22573176_ChIP-Seq_HFKS_Human1.00437128
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99987503
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99093908
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95587149
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.95421909
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95256631
99* MITF_21258399_ChIP-Seq_MELANOMA_Human0.95214518
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94992816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.24709438
2MP0005171_absent_coat_pigmentation4.69046707
3MP0000015_abnormal_ear_pigmentation4.22763779
4MP0005409_darkened_coat_color3.75171950
5MP0002877_abnormal_melanocyte_morpholog3.72832020
6MP0003172_abnormal_lysosome_physiology3.39702558
7MP0005058_abnormal_lysosome_morphology3.34906892
8MP0004381_abnormal_hair_follicle3.28679894
9MP0000372_irregular_coat_pigmentation3.20153895
10MP0003436_decreased_susceptibility_to2.64895002
11MP0005257_abnormal_intraocular_pressure2.61305167
12MP0003303_peritoneal_inflammation2.57699437
13MP0005451_abnormal_body_composition2.50391394
14MP0000371_diluted_coat_color2.45524292
15MP0005174_abnormal_tail_pigmentation2.30062228
16MP0003705_abnormal_hypodermis_morpholog2.22410023
17MP0005408_hypopigmentation2.10183184
18MP0009840_abnormal_foam_cell2.08711233
19MP0008260_abnormal_autophagy2.06503935
20MP0005075_abnormal_melanosome_morpholog2.01735934
21MP0001849_ear_inflammation1.94614808
22MP0002419_abnormal_innate_immunity1.81264657
23MP0009278_abnormal_bone_marrow1.72259762
24MP0003300_gastrointestinal_ulcer1.72112968
25MP0002095_abnormal_skin_pigmentation1.71051636
26MP0002075_abnormal_coat/hair_pigmentati1.67043498
27MP0001348_abnormal_lacrimal_gland1.65655038
28MP0003191_abnormal_cellular_cholesterol1.61302273
29MP0001835_abnormal_antigen_presentation1.58187405
30MP0004947_skin_inflammation1.56069457
31MP0005671_abnormal_response_to1.54080358
32MP0005025_abnormal_response_to1.52958683
33MP0003453_abnormal_keratinocyte_physiol1.52265819
34MP0000569_abnormal_digit_pigmentation1.51144056
35MP0005076_abnormal_cell_differentiation1.45035881
36MP0002998_abnormal_bone_remodeling1.45033703
37MP0006082_CNS_inflammation1.43447932
38MP0005000_abnormal_immune_tolerance1.41190025
39MP0003091_abnormal_cell_migration1.38941048
40MP0001790_abnormal_immune_system1.35442574
41MP0005387_immune_system_phenotype1.35442574
42MP0001533_abnormal_skeleton_physiology1.34009285
43MP0001186_pigmentation_phenotype1.31844039
44MP0002452_abnormal_antigen_presenting1.30132593
45MP0003724_increased_susceptibility_to1.24937404
46MP0003566_abnormal_cell_adhesion1.23283714
47MP0000685_abnormal_immune_system1.21377194
48MP0005464_abnormal_platelet_physiology1.21135417
49MP0002420_abnormal_adaptive_immunity1.19754635
50MP0001819_abnormal_immune_cell1.19297072
51MP0002723_abnormal_immune_serum1.18558754
52MP0002089_abnormal_postnatal_growth/wei1.17008909
53MP0001800_abnormal_humoral_immune1.16472911
54MP0009333_abnormal_splenocyte_physiolog1.15284897
55MP0003763_abnormal_thymus_physiology1.14499306
56MP0002148_abnormal_hypersensitivity_rea1.11964743
57MP0004510_myositis1.09902634
58MP0000604_amyloidosis1.09656771
59MP0009785_altered_susceptibility_to1.07691540
60MP0002405_respiratory_system_inflammati1.05085277
61MP0000858_altered_metastatic_potential1.00292043
62MP0010234_abnormal_vibrissa_follicle0.99696825
63MP0004808_abnormal_hematopoietic_stem0.98593865
64MP0005397_hematopoietic_system_phenotyp0.94629511
65MP0001545_abnormal_hematopoietic_system0.94629511
66MP0001851_eye_inflammation0.90382750
67MP0005248_abnormal_Harderian_gland0.88540373
68MP0003279_aneurysm0.87964065
69MP0000716_abnormal_immune_system0.87487086
70MP0002398_abnormal_bone_marrow0.86812236
71MP0001958_emphysema0.86552863
72MP0008438_abnormal_cutaneous_collagen0.86079569
73MP0003329_amyloid_beta_deposits0.85210148
74MP0005310_abnormal_salivary_gland0.84102735
75MP0003075_altered_response_to0.81034187
76MP0010155_abnormal_intestine_physiology0.79953240
77MP0001845_abnormal_inflammatory_respons0.79432495
78MP0000343_altered_response_to0.78819025
79MP0000678_abnormal_parathyroid_gland0.78715593
80MP0003448_altered_tumor_morphology0.77691086
81MP0001324_abnormal_eye_pigmentation0.76823405
82MP0002429_abnormal_blood_cell0.74519954
83MP0002254_reproductive_system_inflammat0.74372348
84MP0002396_abnormal_hematopoietic_system0.72043567
85MP0002933_joint_inflammation0.71943822
86MP0008469_abnormal_protein_level0.71246320
87MP0003183_abnormal_peptide_metabolism0.70427393
88MP0003878_abnormal_ear_physiology0.70117027
89MP0005377_hearing/vestibular/ear_phenot0.70117027
90MP0004185_abnormal_adipocyte_glucose0.69807380
91MP0002722_abnormal_immune_system0.68453779
92MP0003828_pulmonary_edema0.67982867
93MP0004858_abnormal_nervous_system0.66961450
94MP0001853_heart_inflammation0.66575249
95MP0001873_stomach_inflammation0.63072819
96MP0004233_abnormal_muscle_weight0.62779218
97MP0005390_skeleton_phenotype0.62379303
98MP0000689_abnormal_spleen_morphology0.61411474
99MP0003795_abnormal_bone_structure0.60420475
100MP0005666_abnormal_adipose_tissue0.59670372

Predicted human phenotypes

RankGene SetZ-score
1Ocular albinism (HP:0001107)4.70909353
2Abnormality of glycolipid metabolism (HP:0010969)4.44227985
3Abnormality of liposaccharide metabolism (HP:0010968)4.44227985
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.44227985
5Aplasia/Hypoplasia of the fovea (HP:0008060)3.84385118
6Hypoplasia of the fovea (HP:0007750)3.84385118
7Iris hypopigmentation (HP:0007730)3.76838309
8White forelock (HP:0002211)3.50655163
9Eczematoid dermatitis (HP:0000976)3.41807466
10Abnormality of macrophages (HP:0004311)3.40010459
11Aplasia/Hypoplasia of the macula (HP:0008059)3.31983139
12Blue irides (HP:0000635)3.29218675
13Increased cerebral lipofuscin (HP:0011813)3.23225990
14Thin bony cortex (HP:0002753)3.20061321
15Dysostosis multiplex (HP:0000943)3.12339215
16Broad face (HP:0000283)3.10542407
17Aplasia/Hypoplasia affecting the retina (HP:0008061)3.05238157
18Loss of speech (HP:0002371)3.02274057
19Hypopigmentation of the fundus (HP:0007894)2.92326123
20Abnormality of the fovea (HP:0000493)2.92089148
21Cerebral aneurysm (HP:0004944)2.84050322
22Patchy hypopigmentation of hair (HP:0011365)2.78532823
23Recurrent abscess formation (HP:0002722)2.77473548
24Recurrent bacterial skin infections (HP:0005406)2.75544902
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70639846
26Abnormality of polysaccharide metabolism (HP:0011012)2.70639846
27Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70639846
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.63425715
29Mucopolysacchariduria (HP:0008155)2.62567077
30Urinary glycosaminoglycan excretion (HP:0003541)2.62567077
31Vacuolated lymphocytes (HP:0001922)2.59826122
32Nuclear cataract (HP:0100018)2.53131923
33Myocardial infarction (HP:0001658)2.41332458
34Hyperacusis (HP:0010780)2.39692272
35J-shaped sella turcica (HP:0002680)2.37534348
36Asymmetric septal hypertrophy (HP:0001670)2.32658788
37Distal lower limb amyotrophy (HP:0008944)2.23927041
38Vertebral compression fractures (HP:0002953)2.20581970
39Thoracic kyphosis (HP:0002942)2.17685683
40Gingivitis (HP:0000230)2.15411095
41Peripheral hypomyelination (HP:0007182)2.10764148
42Premature graying of hair (HP:0002216)2.10530648
43Colitis (HP:0002583)2.09097102
44Cellulitis (HP:0100658)2.08272008
45Global brain atrophy (HP:0002283)2.05811450
46Abnormality of the thoracic spine (HP:0100711)2.02248376
47Recurrent gram-negative bacterial infections (HP:0005420)2.02122844
48Distal upper limb amyotrophy (HP:0007149)1.98229339
49Upper limb amyotrophy (HP:0009129)1.98229339
50Pustule (HP:0200039)1.98024110
51Ulnar bowing (HP:0003031)1.97793962
52Increased connective tissue (HP:0009025)1.96533188
53Increased IgE level (HP:0003212)1.94606978
54Obstructive lung disease (HP:0006536)1.94358336
55Chronic obstructive pulmonary disease (HP:0006510)1.94358336
56Cervical subluxation (HP:0003308)1.94341893
57Myositis (HP:0100614)1.92814138
58Distal lower limb muscle weakness (HP:0009053)1.92002766
59Hepatosplenomegaly (HP:0001433)1.91931489
60Protuberant abdomen (HP:0001538)1.90596652
61Mediastinal lymphadenopathy (HP:0100721)1.90295918
62Cerebral inclusion bodies (HP:0100314)1.90131270
63Gastrointestinal inflammation (HP:0004386)1.88872930
64Segmental peripheral demyelination/remyelination (HP:0003481)1.88161167
65Neuronal loss in central nervous system (HP:0002529)1.87802727
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87501834
67Hemorrhage of the eye (HP:0011885)1.86824382
68Albinism (HP:0001022)1.86178264
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85473237
70Systemic lupus erythematosus (HP:0002725)1.84851635
71Hypoplasia of the iris (HP:0007676)1.82785796
72Supernumerary nipples (HP:0002558)1.81936462
73Recurrent fungal infections (HP:0002841)1.81857387
74Upper motor neuron abnormality (HP:0002127)1.79644827
75Slow saccadic eye movements (HP:0000514)1.78901559
76Generalized hypopigmentation (HP:0007513)1.78901512
77Bone pain (HP:0002653)1.78055736
78Inflammation of the large intestine (HP:0002037)1.77133941
79Recurrent skin infections (HP:0001581)1.77017138
80Axonal loss (HP:0003447)1.76825614
81Interstitial pulmonary disease (HP:0006530)1.76047421
82Neurofibrillary tangles (HP:0002185)1.75624610
83Obstructive sleep apnea (HP:0002870)1.75612823
84Deformed sella turcica (HP:0002681)1.75488589
85Disproportionate tall stature (HP:0001519)1.75214021
86Spondylolisthesis (HP:0003302)1.75173009
87Gastrointestinal infarctions (HP:0005244)1.73771257
88Orchitis (HP:0100796)1.73730046
89Joint stiffness (HP:0001387)1.72960818
90Premature loss of primary teeth (HP:0006323)1.72164256
91Heterochromia iridis (HP:0001100)1.70386973
92Premature rupture of membranes (HP:0001788)1.68168626
93Onion bulb formation (HP:0003383)1.67505475
94Achilles tendon contracture (HP:0001771)1.66213139
95Purpura (HP:0000979)1.64008482
96Natal tooth (HP:0000695)1.63128648
97Freckling (HP:0001480)1.61958360
98Spontaneous hematomas (HP:0007420)1.61845533
99Hypertriglyceridemia (HP:0002155)1.61623238
100Pathologic fracture (HP:0002756)1.61180804

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.07210107
2PRPF4B3.39250691
3ERN12.64061804
4MAP4K12.56820400
5SIK12.55979665
6ICK2.41781629
7IRAK32.40629282
8RIPK42.16037934
9SMG12.09932884
10MAP2K31.93636120
11MAP3K31.90252195
12MAP3K131.88472902
13TTN1.87177927
14BLK1.80745328
15TYK21.76839358
16CDK121.64835911
17RIPK11.63875716
18MAP3K141.59248256
19MAP3K111.52060442
20ZAP701.51639664
21EEF2K1.49146202
22TAOK21.42189610
23RPS6KA21.36533587
24IRAK41.35764583
25TBK11.34043074
26SIK21.32770262
27MARK21.32277179
28PRKD21.31827592
29CAMK1D1.29851934
30PKN21.29285883
31CSK1.26642416
32NME21.26192581
33MST1R1.24872431
34DDR21.24540267
35CDC42BPA1.20183853
36PDPK11.17247562
37PTK61.16647687
38JAK31.16362752
39TNK21.16199810
40MARK31.14221363
41CAMKK11.11821233
42IRAK21.10254713
43TAOK11.10120191
44PAK41.07156189
45KSR21.04268930
46MATK1.03480163
47FGFR41.02902547
48EPHB11.02283819
49PRKD31.01567933
50MAP3K11.01182604
51MAP3K70.97367964
52MAP3K60.88503869
53MAP3K100.88394817
54MTOR0.88230185
55RPS6KC10.88122076
56RPS6KL10.88122076
57PDK10.86810564
58TESK10.86109730
59TESK20.86040980
60MAPK150.85971749
61FGR0.84530227
62PDGFRA0.83353065
63HCK0.81838350
64SIK30.77877707
65GRK60.77161044
66TGFBR20.76919514
67NEK90.76903941
68CAMK1G0.76863488
69JAK10.75791167
70BTK0.74871416
71STK380.74465050
72RPS6KA60.70516612
73MAPK120.68424045
74MAPK110.66186933
75CSF1R0.65412402
76PDK20.65339383
77BMX0.64951083
78CDK60.61277694
79KIT0.60800394
80FES0.60760794
81CDK40.60290207
82HIPK20.60287904
83PIM20.59741412
84IKBKB0.59664194
85MAP2K60.59613751
86MAP3K80.58735482
87MAPK70.58163677
88CHUK0.56793133
89IKBKE0.53563281
90DYRK1B0.53362124
91LCK0.49959335
92RPS6KA10.49671932
93PDGFRB0.49607872
94JAK20.49576461
95PRKG20.49189229
96SYK0.47062935
97TYRO30.46827346
98SGK30.44798920
99ARAF0.44612249
100MOS0.44169013

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.22226920
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.58066974
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.35778087
4Osteoclast differentiation_Homo sapiens_hsa043802.23928893
5Lysosome_Homo sapiens_hsa041422.13768115
6Acute myeloid leukemia_Homo sapiens_hsa052212.07627060
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94891802
8B cell receptor signaling pathway_Homo sapiens_hsa046621.79094367
9Leishmaniasis_Homo sapiens_hsa051401.72090565
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71023870
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68370850
12Chronic myeloid leukemia_Homo sapiens_hsa052201.63713868
13Tuberculosis_Homo sapiens_hsa051521.49794489
14VEGF signaling pathway_Homo sapiens_hsa043701.49058896
15Notch signaling pathway_Homo sapiens_hsa043301.44939997
16Non-small cell lung cancer_Homo sapiens_hsa052231.44705893
17Toxoplasmosis_Homo sapiens_hsa051451.43682078
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40335163
19TNF signaling pathway_Homo sapiens_hsa046681.38076891
20Bladder cancer_Homo sapiens_hsa052191.33222036
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.31685315
22Influenza A_Homo sapiens_hsa051641.27072088
23Pancreatic cancer_Homo sapiens_hsa052121.22064647
24Hepatitis B_Homo sapiens_hsa051611.21839360
25Staphylococcus aureus infection_Homo sapiens_hsa051501.18311690
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17509804
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17227150
28Malaria_Homo sapiens_hsa051441.15425484
29mTOR signaling pathway_Homo sapiens_hsa041501.15407966
30Measles_Homo sapiens_hsa051621.14371009
31T cell receptor signaling pathway_Homo sapiens_hsa046601.13553478
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.13209221
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.10793239
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.10318258
35Endometrial cancer_Homo sapiens_hsa052131.06963126
36Hematopoietic cell lineage_Homo sapiens_hsa046401.04228274
37Chemokine signaling pathway_Homo sapiens_hsa040621.00450671
38Fructose and mannose metabolism_Homo sapiens_hsa000511.00435028
39Phospholipase D signaling pathway_Homo sapiens_hsa040720.99944403
40Phagosome_Homo sapiens_hsa041450.99711700
41Hepatitis C_Homo sapiens_hsa051600.99650958
42Allograft rejection_Homo sapiens_hsa053300.99375071
43Renal cell carcinoma_Homo sapiens_hsa052110.98200750
44Apoptosis_Homo sapiens_hsa042100.98149790
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97628066
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.96026743
47Inositol phosphate metabolism_Homo sapiens_hsa005620.94613939
48Prolactin signaling pathway_Homo sapiens_hsa049170.94498950
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94142375
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93957056
51Viral myocarditis_Homo sapiens_hsa054160.91547418
52Herpes simplex infection_Homo sapiens_hsa051680.90370841
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.89852646
54Endocytosis_Homo sapiens_hsa041440.89478183
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88384790
56Insulin resistance_Homo sapiens_hsa049310.88076959
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.86876312
58Small cell lung cancer_Homo sapiens_hsa052220.86744081
59Graft-versus-host disease_Homo sapiens_hsa053320.86671603
60Salmonella infection_Homo sapiens_hsa051320.86554064
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86471795
62Autoimmune thyroid disease_Homo sapiens_hsa053200.86334342
63Pertussis_Homo sapiens_hsa051330.85534188
64Amoebiasis_Homo sapiens_hsa051460.83991252
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83920562
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82853413
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82524215
68GnRH signaling pathway_Homo sapiens_hsa049120.82416070
69Legionellosis_Homo sapiens_hsa051340.82358636
70Viral carcinogenesis_Homo sapiens_hsa052030.81853811
71Insulin signaling pathway_Homo sapiens_hsa049100.80481880
72Antigen processing and presentation_Homo sapiens_hsa046120.79650933
73ErbB signaling pathway_Homo sapiens_hsa040120.78488987
74Galactose metabolism_Homo sapiens_hsa000520.77063435
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76756746
76Platelet activation_Homo sapiens_hsa046110.76693639
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.74909987
78Glioma_Homo sapiens_hsa052140.74519050
79Prostate cancer_Homo sapiens_hsa052150.74149318
80Pentose phosphate pathway_Homo sapiens_hsa000300.74072814
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73915330
82Shigellosis_Homo sapiens_hsa051310.73569984
83Prion diseases_Homo sapiens_hsa050200.71887707
84Choline metabolism in cancer_Homo sapiens_hsa052310.71212858
85Estrogen signaling pathway_Homo sapiens_hsa049150.69569935
86Rheumatoid arthritis_Homo sapiens_hsa053230.69001787
87Thyroid cancer_Homo sapiens_hsa052160.68114702
88HTLV-I infection_Homo sapiens_hsa051660.67612601
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67053797
90Fatty acid biosynthesis_Homo sapiens_hsa000610.66247989
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65956231
92Colorectal cancer_Homo sapiens_hsa052100.65934187
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64097024
94Proteoglycans in cancer_Homo sapiens_hsa052050.63375654
95Type II diabetes mellitus_Homo sapiens_hsa049300.62833069
96Focal adhesion_Homo sapiens_hsa045100.62607219
97African trypanosomiasis_Homo sapiens_hsa051430.60209931
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.58551592
99HIF-1 signaling pathway_Homo sapiens_hsa040660.57771150
100FoxO signaling pathway_Homo sapiens_hsa040680.56376794

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