ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein complex biogenesis (GO:0070271)	5.55939996
2	respiratory chain complex IV assembly (GO:0008535)	5.30893732
3	cytochrome complex assembly (GO:0017004)	5.22217623
4	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.18114886
5	mitochondrial respiratory chain complex assembly (GO:0033108)	5.17963473
6	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.13060212
7	viral transcription (GO:0019083)	4.95114548
8	peptidyl-histidine modification (GO:0018202)	4.92617324
9	iron-sulfur cluster assembly (GO:0016226)	4.86347834
10	metallo-sulfur cluster assembly (GO:0031163)	4.86347834
11	translational termination (GO:0006415)	4.77772549
12	NADH dehydrogenase complex assembly (GO:0010257)	4.59353820
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.59353820
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.59353820
15	ribosomal small subunit biogenesis (GO:0042274)	4.41799480
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.30027069
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.26354385
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.24324254
19	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.24324254
20	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	4.20827481
21	cotranslational protein targeting to membrane (GO:0006613)	4.20681832
22	deoxyribonucleotide catabolic process (GO:0009264)	4.17106044
23	translational elongation (GO:0006414)	4.13914278
24	pyrimidine nucleotide catabolic process (GO:0006244)	4.11922584
25	protein targeting to ER (GO:0045047)	4.11428414
26	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.10949462
27	ATP synthesis coupled proton transport (GO:0015986)	4.10949462
28	deoxyribose phosphate catabolic process (GO:0046386)	4.05195323
29	regulation of mitochondrial translation (GO:0070129)	4.02550230
30	respiratory electron transport chain (GO:0022904)	3.99859645
31	protein localization to endoplasmic reticulum (GO:0070972)	3.99691551
32	electron transport chain (GO:0022900)	3.98666026
33	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.98483286
34	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.94653848
35	ribosomal small subunit assembly (GO:0000028)	3.94052995
36	maturation of SSU-rRNA (GO:0030490)	3.90224436
37	base-excision repair, AP site formation (GO:0006285)	3.88895811
38	viral life cycle (GO:0019058)	3.77142823
39	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.74020313
40	cellular protein complex disassembly (GO:0043624)	3.65600592
41	protein neddylation (GO:0045116)	3.62433538
42	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.54374761
43	oxidative phosphorylation (GO:0006119)	3.53281345
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.51438575
45	seminiferous tubule development (GO:0072520)	3.46522072
46	protein-cofactor linkage (GO:0018065)	3.43991421
47	pseudouridine synthesis (GO:0001522)	3.42698346
48	purine deoxyribonucleotide catabolic process (GO:0009155)	3.40870098
49	chaperone-mediated protein transport (GO:0072321)	3.39252405
50	translational initiation (GO:0006413)	3.33255224
51	translation (GO:0006412)	3.28920626
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.19932082
53	protein targeting to mitochondrion (GO:0006626)	3.18395794
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.17442451
55	DNA deamination (GO:0045006)	3.17420444
56	protein complex disassembly (GO:0043241)	3.16624635
57	adaptation of signaling pathway (GO:0023058)	3.16134151
58	establishment of protein localization to mitochondrion (GO:0072655)	3.12386430
59	water-soluble vitamin biosynthetic process (GO:0042364)	3.12336863
60	synaptic transmission, dopaminergic (GO:0001963)	3.11202481
61	branched-chain amino acid catabolic process (GO:0009083)	3.10481366
62	protein maturation by protein folding (GO:0022417)	3.04452733
63	biotin metabolic process (GO:0006768)	3.01556698
64	hydrogen ion transmembrane transport (GO:1902600)	2.98647499
65	macromolecular complex disassembly (GO:0032984)	2.98043762
66	cellular component biogenesis (GO:0044085)	2.96421143
67	positive regulation of TOR signaling (GO:0032008)	2.95875543
68	ATP biosynthetic process (GO:0006754)	2.93996347
69	regulation of glucokinase activity (GO:0033131)	2.92405186
70	regulation of hexokinase activity (GO:1903299)	2.92405186
71	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.92256173
72	DNA damage response, detection of DNA damage (GO:0042769)	2.91337976
73	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.87151858
74	GTP biosynthetic process (GO:0006183)	2.86745622
75	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.86127565
76	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.83210429
77	aldehyde catabolic process (GO:0046185)	2.81472292
78	protein localization to mitochondrion (GO:0070585)	2.79411810
79	proton transport (GO:0015992)	2.77528250
80	establishment of mitochondrion localization (GO:0051654)	2.75873624
81	tRNA processing (GO:0008033)	2.75127703
82	mRNA catabolic process (GO:0006402)	2.71883689
83	hydrogen transport (GO:0006818)	2.71511850
84	amyloid precursor protein catabolic process (GO:0042987)	2.69902475
85	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.68115385
86	mitochondrion transport along microtubule (GO:0047497)	2.68115385
87	ATP hydrolysis coupled proton transport (GO:0015991)	2.67635499
88	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.67635499
89	protein targeting to membrane (GO:0006612)	2.64584926
90	deoxyribose phosphate metabolic process (GO:0019692)	2.63011337
91	2-deoxyribonucleotide metabolic process (GO:0009394)	2.62998375
92	pharyngeal system development (GO:0060037)	2.61476743
93	dorsal/ventral neural tube patterning (GO:0021904)	2.59803215
94	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.59701628
95	termination of RNA polymerase III transcription (GO:0006386)	2.59701628
96	viral protein processing (GO:0019082)	2.59654201
97	response to misfolded protein (GO:0051788)	2.58984759
98	positive regulation of prostaglandin secretion (GO:0032308)	2.58106790
99	protein import into peroxisome matrix (GO:0016558)	2.57778667
100	nitric oxide mediated signal transduction (GO:0007263)	2.57346481

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.32921102
2	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.90984234
3	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.79101012
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.65566781
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.47944291
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.45538421
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.31580376
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.26488976
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90434663
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.78471512
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.64029263
12	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.61097699
13	EZH2_22144423_ChIP-Seq_EOC_Human	2.53282260
14	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.46997549
15	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.46062238
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.40771989
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.35410410
18	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.31116734
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.29223555
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.23497800
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.21067665
22	VDR_23849224_ChIP-Seq_CD4+_Human	2.17194188
23	MYC_18940864_ChIP-ChIP_HL60_Human	2.10334942
24	GABP_19822575_ChIP-Seq_HepG2_Human	2.07116776
25	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.06030485
26	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.01414541
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.99413927
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.94032768
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.92304595
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.86210468
31	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.85340178
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.85106390
33	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.84176806
34	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.81447447
35	CIITA_25753668_ChIP-Seq_RAJI_Human	1.66848789
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.63611970
37	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.61671388
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.58565052
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.56816981
40	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.56801401
41	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.52191687
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.51938110
43	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.48687478
44	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.42600112
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.39842344
46	* FOXP1_21924763_ChIP-Seq_HESCs_Human	1.39651123
47	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.38926017
48	ZNF274_21170338_ChIP-Seq_K562_Hela	1.36445386
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.35979041
50	ERA_21632823_ChIP-Seq_H3396_Human	1.35911482
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.35861624
52	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.35812277
53	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.33878382
54	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.32613253
55	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.32568203
56	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30137631
57	BCL6_27268052_Chip-Seq_Bcells_Human	1.29283036
58	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27439628
59	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27372006
60	P68_20966046_ChIP-Seq_HELA_Human	1.22521495
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.22146987
62	E2F1_20622854_ChIP-Seq_HELA_Human	1.21130662
63	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.18371118
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17077416
65	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.17044715
66	KDM5A_27292631_Chip-Seq_BREAST_Human	1.15959064
67	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.15392048
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13849159
69	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.13193690
70	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.12503174
71	PHF8_20622854_ChIP-Seq_HELA_Human	1.11140938
72	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.10930593
73	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.10895633
74	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.08783594
75	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.06290127
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.06246753
77	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05126532
78	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.04601611
79	BCOR_27268052_Chip-Seq_Bcells_Human	1.04434850
80	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04003472
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.03629433
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.03344637
83	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.03040455
84	CTCF_20526341_ChIP-Seq_ESCs_Human	1.00067454
85	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.98411104
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97793138
87	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.96208298
88	SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human	0.96088639
89	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95000454
90	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.93700212
91	CTCF_21964334_Chip-Seq_Bcells_Human	0.93694811
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92793985
93	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91536618
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89213442
95	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.89100729
96	RAC3_21632823_ChIP-Seq_H3396_Human	0.86377501
97	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86200416
98	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.85809230
99	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.85479637
100	P300_27268052_Chip-Seq_Bcells_Human	0.85474867

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002822_catalepsy	3.57209102
2	MP0001905_abnormal_dopamine_level	2.69867797
3	MP0002163_abnormal_gland_morphology	2.58060289
4	MP0005423_abnormal_somatic_nervous	2.52540314
5	MP0002837_dystrophic_cardiac_calcinosis	2.32536449
6	MP0001986_abnormal_taste_sensitivity	2.29764831
7	MP0005084_abnormal_gallbladder_morpholo	2.18582193
8	MP0001661_extended_life_span	2.13944524
9	MP0004147_increased_porphyrin_level	2.11289955
10	MP0005646_abnormal_pituitary_gland	2.10290522
11	MP0008058_abnormal_DNA_repair	2.07171086
12	MP0005379_endocrine/exocrine_gland_phen	2.06076173
13	MP0006276_abnormal_autonomic_nervous	1.99723613
14	MP0006072_abnormal_retinal_apoptosis	1.97262297
15	MP0001968_abnormal_touch/_nociception	1.90783632
16	MP0002909_abnormal_adrenal_gland	1.88149321
17	MP0006292_abnormal_olfactory_placode	1.85999819
18	MP0002638_abnormal_pupillary_reflex	1.84801259
19	MP0002234_abnormal_pharynx_morphology	1.84309347
20	MP0005451_abnormal_body_composition	1.82334278
21	MP0001529_abnormal_vocalization	1.81458759
22	MP0003186_abnormal_redox_activity	1.76152490
23	MP0003011_delayed_dark_adaptation	1.75745974
24	MP0000631_abnormal_neuroendocrine_gland	1.70221027
25	MP0003786_premature_aging	1.69212992
26	MP0002138_abnormal_hepatobiliary_system	1.68850260
27	MP0005645_abnormal_hypothalamus_physiol	1.63712335
28	MP0003195_calcinosis	1.58566954
29	MP0000678_abnormal_parathyroid_gland	1.57934041
30	MP0008877_abnormal_DNA_methylation	1.56364461
31	MP0002735_abnormal_chemical_nociception	1.54110986
32	MP0003787_abnormal_imprinting	1.52943390
33	MP0002277_abnormal_respiratory_mucosa	1.52513316
34	MP0001727_abnormal_embryo_implantation	1.43148213
35	MP0009745_abnormal_behavioral_response	1.41258500
36	MP0005220_abnormal_exocrine_pancreas	1.39975128
37	MP0004133_heterotaxia	1.38523923
38	MP0006036_abnormal_mitochondrial_physio	1.34781045
39	MP0002653_abnormal_ependyma_morphology	1.34500310
40	MP0002184_abnormal_innervation	1.33695442
41	MP0003122_maternal_imprinting	1.33470130
42	MP0005551_abnormal_eye_electrophysiolog	1.32926226
43	MP0002938_white_spotting	1.32370503
44	MP0002272_abnormal_nervous_system	1.27901642
45	MP0001502_abnormal_circadian_rhythm	1.24665117
46	MP0002249_abnormal_larynx_morphology	1.23777233
47	MP0005332_abnormal_amino_acid	1.23735787
48	MP0000049_abnormal_middle_ear	1.23672764
49	MP0003693_abnormal_embryo_hatching	1.19706129
50	MP0002160_abnormal_reproductive_system	1.19396994
51	MP0008872_abnormal_physiological_respon	1.18153800
52	MP0002572_abnormal_emotion/affect_behav	1.17284525
53	MP0005670_abnormal_white_adipose	1.17148329
54	MP0006035_abnormal_mitochondrial_morpho	1.15901944
55	MP0002102_abnormal_ear_morphology	1.11899108
56	MP0005408_hypopigmentation	1.11123199
57	MP0002557_abnormal_social/conspecific_i	1.10112465
58	MP0005253_abnormal_eye_physiology	1.09356894
59	MP0008875_abnormal_xenobiotic_pharmacok	1.07755610
60	MP0001764_abnormal_homeostasis	1.05854293
61	MP0003698_abnormal_male_reproductive	1.05706630
62	MP0002736_abnormal_nociception_after	1.04685031
63	MP0008995_early_reproductive_senescence	1.01023462
64	MP0003123_paternal_imprinting	1.00447796
65	MP0004924_abnormal_behavior	0.99499374
66	MP0005386_behavior/neurological_phenoty	0.99499374
67	MP0000470_abnormal_stomach_morphology	0.98301426
68	MP0005389_reproductive_system_phenotype	0.98164025
69	MP0002229_neurodegeneration	0.96906725
70	MP0005636_abnormal_mineral_homeostasis	0.96769145
71	MP0002693_abnormal_pancreas_physiology	0.96655238
72	MP0003121_genomic_imprinting	0.95566423
73	MP0002139_abnormal_hepatobiliary_system	0.94475322
74	MP0002734_abnormal_mechanical_nocicepti	0.93286407
75	MP0005075_abnormal_melanosome_morpholog	0.92981411
76	MP0008789_abnormal_olfactory_epithelium	0.91753809
77	MP0001984_abnormal_olfaction	0.91652043
78	MP0001145_abnormal_male_reproductive	0.91156978
79	MP0002063_abnormal_learning/memory/cond	0.91041809
80	MP0000372_irregular_coat_pigmentation	0.89749244
81	MP0002210_abnormal_sex_determination	0.89531193
82	MP0009379_abnormal_foot_pigmentation	0.89142209
83	MP0005499_abnormal_olfactory_system	0.88986133
84	MP0005394_taste/olfaction_phenotype	0.88986133
85	MP0002282_abnormal_trachea_morphology	0.85566397
86	MP0004142_abnormal_muscle_tone	0.85380771
87	MP0005266_abnormal_metabolism	0.84927732
88	MP0002132_abnormal_respiratory_system	0.84451849
89	MP0005367_renal/urinary_system_phenotyp	0.83960587
90	MP0000516_abnormal_urinary_system	0.83960587
91	MP0000639_abnormal_adrenal_gland	0.83818819
92	MP0001919_abnormal_reproductive_system	0.83450375
93	MP0004043_abnormal_pH_regulation	0.82932776
94	MP0001944_abnormal_pancreas_morphology	0.82915753
95	MP0002752_abnormal_somatic_nervous	0.82297341
96	MP0001929_abnormal_gametogenesis	0.81238947
97	MP0001756_abnormal_urination	0.81067377
98	MP0000653_abnormal_sex_gland	0.80231163
99	MP0003137_abnormal_impulse_conducting	0.78229583
100	MP0003718_maternal_effect	0.78165931

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hepatic necrosis (HP:0002605)	4.70050551
2	Hepatocellular necrosis (HP:0001404)	4.50216808
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.28693259
4	Mitochondrial inheritance (HP:0001427)	4.27435826
5	Acute necrotizing encephalopathy (HP:0006965)	3.93462285
6	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.89217825
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.89217825
8	Congenital malformation of the right heart (HP:0011723)	3.85714261
9	Double outlet right ventricle (HP:0001719)	3.85714261
10	Increased CSF lactate (HP:0002490)	3.60621141
11	Increased intramyocellular lipid droplets (HP:0012240)	3.60539930
12	Acute encephalopathy (HP:0006846)	3.57342879
13	Increased muscle lipid content (HP:0009058)	3.31092586
14	Progressive macrocephaly (HP:0004481)	3.22391551
15	Lipid accumulation in hepatocytes (HP:0006561)	3.21524654
16	Increased hepatocellular lipid droplets (HP:0006565)	3.11647867
17	Pancreatic fibrosis (HP:0100732)	3.08030644
18	Renal Fanconi syndrome (HP:0001994)	2.97283291
19	Lactic acidosis (HP:0003128)	2.94346173
20	Molar tooth sign on MRI (HP:0002419)	2.91777247
21	Abnormality of midbrain morphology (HP:0002418)	2.91777247
22	Hyperglycinemia (HP:0002154)	2.88768118
23	Sclerocornea (HP:0000647)	2.85992815
24	Abnormality of cells of the erythroid lineage (HP:0012130)	2.79594161
25	Reticulocytopenia (HP:0001896)	2.77491083
26	Abnormal number of erythroid precursors (HP:0012131)	2.76753609
27	Pancreatic cysts (HP:0001737)	2.75216765
28	Generalized aminoaciduria (HP:0002909)	2.72338521
29	Hypoglycemic coma (HP:0001325)	2.71426543
30	Ketosis (HP:0001946)	2.54418487
31	Tachypnea (HP:0002789)	2.50264946
32	Glycosuria (HP:0003076)	2.47767086
33	Abnormality of urine glucose concentration (HP:0011016)	2.47767086
34	Rib fusion (HP:0000902)	2.46856864
35	Cerebral edema (HP:0002181)	2.43569975
36	Cerebral palsy (HP:0100021)	2.39991703
37	Hyperthyroidism (HP:0000836)	2.39501999
38	3-Methylglutaconic aciduria (HP:0003535)	2.39364689
39	Abnormality of the aortic arch (HP:0012303)	2.38789368
40	Tetany (HP:0001281)	2.31965391
41	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.31535920
42	Dicarboxylic aciduria (HP:0003215)	2.31535920
43	Bile duct proliferation (HP:0001408)	2.28912009
44	Abnormal biliary tract physiology (HP:0012439)	2.28912009
45	Increased serum lactate (HP:0002151)	2.28006257
46	Hyperventilation (HP:0002883)	2.27678482
47	Lethargy (HP:0001254)	2.25309432
48	Abnormality of the parathyroid morphology (HP:0011766)	2.23864612
49	Respiratory failure (HP:0002878)	2.23446029
50	Exercise intolerance (HP:0003546)	2.19593237
51	Hyperphosphaturia (HP:0003109)	2.19534930
52	Hypoglycemic seizures (HP:0002173)	2.18352834
53	Brushfield spots (HP:0001088)	2.17665195
54	True hermaphroditism (HP:0010459)	2.17015931
55	Cerebral hypomyelination (HP:0006808)	2.16711772
56	Type I transferrin isoform profile (HP:0003642)	2.14098801
57	Hypomagnesemia (HP:0002917)	2.08125746
58	Hyperinsulinemic hypoglycemia (HP:0000825)	2.06574752
59	Opisthotonus (HP:0002179)	2.06201887
60	Medial flaring of the eyebrow (HP:0010747)	2.05363085
61	Polyphagia (HP:0002591)	2.02660832
62	Methylmalonic acidemia (HP:0002912)	2.01245973
63	Abnormality of renal resorption (HP:0011038)	2.00043523
64	Abnormal protein glycosylation (HP:0012346)	1.97217345
65	Abnormal glycosylation (HP:0012345)	1.97217345
66	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97217345
67	Abnormal protein N-linked glycosylation (HP:0012347)	1.97217345
68	Metabolic acidosis (HP:0001942)	1.95647989
69	Cystic liver disease (HP:0006706)	1.94444638
70	CNS hypomyelination (HP:0003429)	1.93807006
71	Abnormality of the line of Schwalbe (HP:0008048)	1.92577327
72	Neoplasm of the adrenal cortex (HP:0100641)	1.91895633
73	Abnormality of fatty-acid metabolism (HP:0004359)	1.91858907
74	Methylmalonic aciduria (HP:0012120)	1.90690267
75	Truncus arteriosus (HP:0001660)	1.90506970
76	Ragged-red muscle fibers (HP:0003200)	1.89705150
77	Exertional dyspnea (HP:0002875)	1.87517826
78	Symptomatic seizures (HP:0011145)	1.86377389
79	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86046242
80	Posterior embryotoxon (HP:0000627)	1.85897468
81	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.85437877
82	Hypothermia (HP:0002045)	1.84838286
83	Nephronophthisis (HP:0000090)	1.83061020
84	Emotional lability (HP:0000712)	1.81587322
85	Macrocytic anemia (HP:0001972)	1.81449334
86	Muscular hypotonia of the trunk (HP:0008936)	1.80720626
87	Abnormality of magnesium homeostasis (HP:0004921)	1.80538017
88	Abnormal albumin level (HP:0012116)	1.80264478
89	Hypoalbuminemia (HP:0003073)	1.80264478
90	CNS demyelination (HP:0007305)	1.78003117
91	Prominent metopic ridge (HP:0005487)	1.76747657
92	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.75296542
93	Villous atrophy (HP:0011473)	1.74110993
94	Abnormality of small intestinal villus morphology (HP:0011472)	1.74110993
95	Abnormality of the metopic suture (HP:0005556)	1.73483635
96	Epiphyseal stippling (HP:0010655)	1.72558705
97	Renal cortical cysts (HP:0000803)	1.71840549
98	Potter facies (HP:0002009)	1.70381427
99	Facial shape deformation (HP:0011334)	1.70381427
100	Abnormality of DNA repair (HP:0003254)	1.70339426

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	6.17302399
2	BCKDK	3.78412696
3	BMPR1B	3.09472319
4	MUSK	2.86441228
5	ZAK	2.85782549
6	STK16	2.71403329
7	MAPKAPK3	2.49657117
8	MAP4K2	2.31054686
9	PINK1	2.26569215
10	CSNK1G3	2.21290728
11	NUAK1	2.16177620
12	MAPKAPK5	2.03128961
13	MAP3K4	2.01618036
14	NME1	1.97967230
15	TAF1	1.96043168
16	MAP3K11	1.95513817
17	NME2	1.88016958
18	CSNK1G1	1.85018620
19	CSNK1G2	1.83962687
20	DYRK2	1.79398639
21	GRK1	1.79206549
22	VRK1	1.74812715
23	BUB1	1.68065403
24	CSNK1A1L	1.64358119
25	FRK	1.57891602
26	MAP2K7	1.48916001
27	SMG1	1.43064441
28	EEF2K	1.42375386
29	IRAK3	1.40791286
30	FLT3	1.35729631
31	DAPK1	1.30456638
32	WNK4	1.27192149
33	ARAF	1.21449036
34	MAPK13	1.19461685
35	DYRK3	1.17445933
36	LRRK2	1.13986445
37	AURKA	1.06547893
38	RPS6KA5	1.05709092
39	PRKCI	0.96405818
40	TLK1	0.96258456
41	ADRBK2	0.91076538
42	STK39	0.90226711
43	PIM2	0.89414498
44	SRPK1	0.86801024
45	GRK5	0.85613023
46	TESK2	0.85004722
47	CDK8	0.81852278
48	RPS6KB2	0.81070832
49	PLK1	0.79678410
50	CHEK2	0.74370624
51	NTRK2	0.73820125
52	TGFBR1	0.72755192
53	KDR	0.70687557
54	MAP2K6	0.64833606
55	PRKCG	0.63254096
56	BRAF	0.62142087
57	PAK6	0.62091841
58	MOS	0.62072677
59	IRAK2	0.61741817
60	PASK	0.59486219
61	ABL2	0.59406968
62	MAPK15	0.57125124
63	MINK1	0.55800986
64	DAPK3	0.54702174
65	CDK7	0.52059381
66	PLK4	0.51405827
67	HIPK2	0.49115939
68	PAK3	0.48625709
69	CASK	0.48249260
70	PRKAA1	0.47375456
71	DAPK2	0.45587245
72	MAPK11	0.43478974
73	CAMKK2	0.42844859
74	WNK3	0.42164445
75	PLK3	0.41331005
76	CSNK1A1	0.41220389
77	CSNK2A2	0.41040868
78	LIMK1	0.39836949
79	TRIM28	0.38321066
80	MAP4K1	0.37653919
81	STK11	0.35334901
82	CAMKK1	0.34001423
83	CDK11A	0.33658077
84	ADRBK1	0.33462170
85	CAMK2D	0.33431504
86	AURKB	0.32746725
87	BRSK1	0.32297928
88	CDK14	0.31636965
89	RPS6KA4	0.31353879
90	PRKD3	0.28392045
91	ATR	0.27936526
92	CDK9	0.27337273
93	CAMK2G	0.27124288
94	CDK15	0.26937550
95	MAP2K4	0.26590653
96	PRKACA	0.25994664
97	RPS6KA2	0.25005160
98	FGFR2	0.24965918
99	CSNK2A1	0.24848506
100	CDK18	0.24604138

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.78042667
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26283374
3	Parkinsons disease_Homo sapiens_hsa05012	3.51792022
4	Sulfur relay system_Homo sapiens_hsa04122	3.09985039
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.57641489
6	Base excision repair_Homo sapiens_hsa03410	2.50923516
7	Huntingtons disease_Homo sapiens_hsa05016	2.49236488
8	Alzheimers disease_Homo sapiens_hsa05010	2.44007513
9	RNA polymerase_Homo sapiens_hsa03020	2.38023990
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.22523179
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20525586
12	Sulfur metabolism_Homo sapiens_hsa00920	2.16019992
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.15515005
14	Peroxisome_Homo sapiens_hsa04146	2.00220498
15	Proteasome_Homo sapiens_hsa03050	1.90260036
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.84790274
17	RNA degradation_Homo sapiens_hsa03018	1.76710364
18	Protein export_Homo sapiens_hsa03060	1.62811594
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.52097099
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.47581758
21	DNA replication_Homo sapiens_hsa03030	1.46141894
22	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41475123
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.40137976
24	Homologous recombination_Homo sapiens_hsa03440	1.35513692
25	Basal transcription factors_Homo sapiens_hsa03022	1.33835075
26	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.32519254
27	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.32184150
28	Purine metabolism_Homo sapiens_hsa00230	1.30247593
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29039801
30	Glutathione metabolism_Homo sapiens_hsa00480	1.28643753
31	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.25974396
32	Regulation of autophagy_Homo sapiens_hsa04140	1.25519210
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.21353393
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.20732263
35	Fatty acid elongation_Homo sapiens_hsa00062	1.17361593
36	Folate biosynthesis_Homo sapiens_hsa00790	1.13209809
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12076404
38	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.11737020
39	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.09035018
40	Mismatch repair_Homo sapiens_hsa03430	1.04739028
41	Metabolic pathways_Homo sapiens_hsa01100	1.04145093
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.02042590
43	Butanoate metabolism_Homo sapiens_hsa00650	1.01133890
44	Phototransduction_Homo sapiens_hsa04744	1.00228498
45	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99233705
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.98918394
47	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.93877969
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.89931617
49	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88227042
50	Spliceosome_Homo sapiens_hsa03040	0.87363590
51	Propanoate metabolism_Homo sapiens_hsa00640	0.84652274
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.84473783
53	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82729626
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.82304680
55	Non-homologous end-joining_Homo sapiens_hsa03450	0.81530053
56	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80233180
57	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.73741324
58	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.73690265
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72039746
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.69415406
61	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.68704783
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.68112725
63	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.62282195
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.60397846
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.59296173
66	Fatty acid degradation_Homo sapiens_hsa00071	0.58603795
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58335606
68	Tyrosine metabolism_Homo sapiens_hsa00350	0.55945531
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55814259
70	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.55171880
71	RNA transport_Homo sapiens_hsa03013	0.54921823
72	Primary immunodeficiency_Homo sapiens_hsa05340	0.53356086
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.52290084
74	One carbon pool by folate_Homo sapiens_hsa00670	0.51913111
75	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50673430
76	Nicotine addiction_Homo sapiens_hsa05033	0.46233192
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44026965
78	Retinol metabolism_Homo sapiens_hsa00830	0.42994114
79	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42344667
80	Vibrio cholerae infection_Homo sapiens_hsa05110	0.41902675
81	Insulin secretion_Homo sapiens_hsa04911	0.41666277
82	Type I diabetes mellitus_Homo sapiens_hsa04940	0.41386036
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41112239
84	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39782310
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.39365444
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39359295
87	Galactose metabolism_Homo sapiens_hsa00052	0.36273983
88	ABC transporters_Homo sapiens_hsa02010	0.36246616
89	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32601044
90	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.30236403
91	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28235223
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.27819350
93	Oocyte meiosis_Homo sapiens_hsa04114	0.26729836
94	Steroid biosynthesis_Homo sapiens_hsa00100	0.26658305
95	Carbon metabolism_Homo sapiens_hsa01200	0.24778716
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24593003
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22819301
98	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.20427766
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.15509597
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.15148593

C19ORF73

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »