ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	6.57279003
2	viral transcription (GO:0019083)	6.11708374
3	translational termination (GO:0006415)	5.74426173
4	ribosomal small subunit assembly (GO:0000028)	5.40496516
5	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.32954771
6	ATP synthesis coupled proton transport (GO:0015986)	5.32954771
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.07431165
8	translational elongation (GO:0006414)	5.05028122
9	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.78470160
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.75229917
11	cotranslational protein targeting to membrane (GO:0006613)	4.68505679
12	protein targeting to ER (GO:0045047)	4.61996115
13	cellular protein complex disassembly (GO:0043624)	4.54952925
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.48744580
15	viral life cycle (GO:0019058)	4.48030759
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.43497905
17	protein localization to endoplasmic reticulum (GO:0070972)	4.40824673
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.37799159
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.36138127
20	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.21901389
21	maturation of SSU-rRNA (GO:0030490)	4.21169913
22	protein complex disassembly (GO:0043241)	4.17575098
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12633378
24	NADH dehydrogenase complex assembly (GO:0010257)	4.12633378
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12633378
26	protein complex biogenesis (GO:0070271)	4.09996229
27	macromolecular complex disassembly (GO:0032984)	3.99800587
28	respiratory electron transport chain (GO:0022904)	3.99354636
29	electron transport chain (GO:0022900)	3.91915047
30	translational initiation (GO:0006413)	3.74632470
31	mitochondrial respiratory chain complex assembly (GO:0033108)	3.72659667
32	pyrimidine nucleotide catabolic process (GO:0006244)	3.65386262
33	ATP biosynthetic process (GO:0006754)	3.63579040
34	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.59415455
35	chaperone-mediated protein transport (GO:0072321)	3.53762106
36	ncRNA 3-end processing (GO:0043628)	3.53257437
37	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.49383619
38	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.46263840
39	GTP biosynthetic process (GO:0006183)	3.46230771
40	protein targeting to mitochondrion (GO:0006626)	3.45555307
41	base-excision repair, AP site formation (GO:0006285)	3.43557499
42	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.40810898
43	deoxyribonucleotide catabolic process (GO:0009264)	3.40660016
44	establishment of protein localization to mitochondrion (GO:0072655)	3.39116620
45	iron-sulfur cluster assembly (GO:0016226)	3.34615846
46	metallo-sulfur cluster assembly (GO:0031163)	3.34615846
47	positive regulation of prostaglandin secretion (GO:0032308)	3.30792102
48	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.28403518
49	purine deoxyribonucleotide catabolic process (GO:0009155)	3.25772603
50	UTP biosynthetic process (GO:0006228)	3.25302617
51	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.24625789
52	translation (GO:0006412)	3.24182217
53	CTP metabolic process (GO:0046036)	3.23565103
54	CTP biosynthetic process (GO:0006241)	3.23565103
55	protein neddylation (GO:0045116)	3.22875060
56	substrate-independent telencephalic tangential migration (GO:0021826)	3.21150651
57	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	3.21150651
58	protein targeting to membrane (GO:0006612)	3.19752061
59	cellular component biogenesis (GO:0044085)	3.17772161
60	protein localization to mitochondrion (GO:0070585)	3.14332395
61	deoxyribose phosphate catabolic process (GO:0046386)	3.13838684
62	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.09709529
63	spinal cord association neuron differentiation (GO:0021527)	3.08207387
64	regulation of mitochondrial translation (GO:0070129)	3.07291808
65	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.04925384
66	termination of RNA polymerase III transcription (GO:0006386)	3.04925384
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.03382125
68	nucleoside triphosphate biosynthetic process (GO:0009142)	3.02273343
69	oxidative phosphorylation (GO:0006119)	3.00082243
70	nonmotile primary cilium assembly (GO:0035058)	2.95800461
71	UTP metabolic process (GO:0046051)	2.94969238
72	mRNA catabolic process (GO:0006402)	2.89932924
73	hydrogen ion transmembrane transport (GO:1902600)	2.88656876
74	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.88179307
75	ribonucleoprotein complex biogenesis (GO:0022613)	2.86163411
76	positive regulation of icosanoid secretion (GO:0032305)	2.86037661
77	guanosine-containing compound biosynthetic process (GO:1901070)	2.85792670
78	ribosomal large subunit biogenesis (GO:0042273)	2.80632915
79	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.79857592
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.79857592
81	positive regulation of fatty acid transport (GO:2000193)	2.78384670
82	behavioral response to nicotine (GO:0035095)	2.77742374
83	cell proliferation in forebrain (GO:0021846)	2.74900229
84	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	2.72265989
85	establishment of mitochondrion localization (GO:0051654)	2.71895447
86	2-deoxyribonucleotide metabolic process (GO:0009394)	2.71854259
87	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.68830688
88	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.66550856
89	deoxyribose phosphate biosynthetic process (GO:0046385)	2.66550856
90	protein-cofactor linkage (GO:0018065)	2.65237176
91	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.64439283
92	left/right pattern formation (GO:0060972)	2.63425755
93	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.62352939
94	regulation of prostaglandin secretion (GO:0032306)	2.61532832
95	neurofilament cytoskeleton organization (GO:0060052)	2.60193641
96	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.59477026
97	RNA catabolic process (GO:0006401)	2.57477434
98	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.56975279
99	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.55618267
100	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.55618267

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.95785918
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.84174505
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.20400311
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92296688
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.86537829
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.78359630
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70166574
8	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.44910770
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.39178434
10	XRN2_22483619_ChIP-Seq_HELA_Human	2.38184565
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.27195065
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.26968261
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.12353160
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.03876276
15	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.01810355
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.01670410
17	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.01144446
18	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.00411867
19	GABP_19822575_ChIP-Seq_HepG2_Human	1.99860967
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.96397873
21	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.93169729
22	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.90625666
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.89442890
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.88436142
25	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.78609874
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.76247022
27	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.76070006
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.73104836
29	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.70992716
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.65953980
31	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.64459418
32	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.59613263
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.58772094
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.56374227
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.55364289
36	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.55292979
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.55108856
38	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.54372311
39	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.53206345
40	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.51086878
41	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50889039
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45415955
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.45242614
44	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.43086278
45	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.41181012
46	P68_20966046_ChIP-Seq_HELA_Human	1.40888811
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.40393448
48	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.40362226
49	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.38364645
50	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.37773440
51	DCP1A_22483619_ChIP-Seq_HELA_Human	1.35872305
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34657805
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.30094257
54	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.29697221
55	CTCF_27219007_Chip-Seq_Bcells_Human	1.28474417
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.26914754
57	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26648017
58	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.23707843
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.22706124
60	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.22585807
61	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21693697
62	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.20791055
63	ZNF263_19887448_ChIP-Seq_K562_Human	1.20434399
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.20164847
65	KDM5A_27292631_Chip-Seq_BREAST_Human	1.19677450
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18058963
67	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.12225351
68	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.12225351
69	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.12090547
70	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.11697610
71	BCL6_27268052_Chip-Seq_Bcells_Human	1.09203233
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.08919856
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.08501381
74	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.08077770
75	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07431045
76	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.05862033
77	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05748615
78	VDR_23849224_ChIP-Seq_CD4+_Human	1.05642409
79	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05249502
80	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.03881834
81	LXR_22292898_ChIP-Seq_THP-1_Human	1.02146974
82	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.01702819
83	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01051885
84	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.00506971
85	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00024548
86	E2F1_20622854_ChIP-Seq_HELA_Human	0.99476970
87	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.98861884
88	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.98055081
89	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.97746000
90	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.96388579
91	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	0.95612767
92	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.95110475
93	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.94605836
94	PHF8_20622854_ChIP-Seq_HELA_Human	0.94398271
95	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.94302903
96	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.93503555
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.93095301
98	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.92841632
99	VDR_21846776_ChIP-Seq_THP-1_Human	0.92673228
100	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.92560717

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.70537149
2	MP0003122_maternal_imprinting	3.24962585
3	MP0003787_abnormal_imprinting	2.90537490
4	MP0009379_abnormal_foot_pigmentation	2.70219783
5	MP0001188_hyperpigmentation	2.61804751
6	MP0004859_abnormal_synaptic_plasticity	2.57077507
7	MP0003880_abnormal_central_pattern	2.28023682
8	MP0002653_abnormal_ependyma_morphology	2.27381947
9	MP0003121_genomic_imprinting	2.18221722
10	MP0008789_abnormal_olfactory_epithelium	2.11304650
11	MP0001968_abnormal_touch/_nociception	2.10204113
12	MP0005394_taste/olfaction_phenotype	2.06684903
13	MP0005499_abnormal_olfactory_system	2.06684903
14	MP0003123_paternal_imprinting	2.06261540
15	MP0002234_abnormal_pharynx_morphology	2.03564395
16	MP0005645_abnormal_hypothalamus_physiol	2.03313441
17	MP0005423_abnormal_somatic_nervous	2.02250802
18	MP0006276_abnormal_autonomic_nervous	2.00799762
19	MP0004145_abnormal_muscle_electrophysio	1.92016042
20	MP0005646_abnormal_pituitary_gland	1.89755108
21	MP0000049_abnormal_middle_ear	1.85319832
22	MP0002822_catalepsy	1.83051895
23	MP0002163_abnormal_gland_morphology	1.82821559
24	MP0010030_abnormal_orbit_morphology	1.82121941
25	MP0003635_abnormal_synaptic_transmissio	1.75464758
26	MP0004133_heterotaxia	1.74797634
27	MP0002733_abnormal_thermal_nociception	1.67236496
28	MP0009745_abnormal_behavioral_response	1.62159289
29	MP0002102_abnormal_ear_morphology	1.62048666
30	MP0002063_abnormal_learning/memory/cond	1.60614866
31	MP0002249_abnormal_larynx_morphology	1.57990482
32	MP0002272_abnormal_nervous_system	1.54589306
33	MP0002064_seizures	1.54445934
34	MP0004885_abnormal_endolymph	1.54276390
35	MP0002938_white_spotting	1.52984684
36	MP0000678_abnormal_parathyroid_gland	1.52793937
37	MP0004142_abnormal_muscle_tone	1.48062067
38	MP0000778_abnormal_nervous_system	1.46841870
39	MP0002557_abnormal_social/conspecific_i	1.46435566
40	MP0001529_abnormal_vocalization	1.44729867
41	MP0001905_abnormal_dopamine_level	1.40657232
42	MP0002736_abnormal_nociception_after	1.39590013
43	MP0008932_abnormal_embryonic_tissue	1.38104773
44	MP0002572_abnormal_emotion/affect_behav	1.37275940
45	MP0004147_increased_porphyrin_level	1.36819828
46	MP0001293_anophthalmia	1.36373971
47	MP0003693_abnormal_embryo_hatching	1.36151407
48	MP0004858_abnormal_nervous_system	1.36110535
49	MP0001984_abnormal_olfaction	1.32577217
50	MP0001970_abnormal_pain_threshold	1.31379255
51	MP0009046_muscle_twitch	1.30512258
52	MP0000631_abnormal_neuroendocrine_gland	1.30336202
53	MP0000955_abnormal_spinal_cord	1.29961513
54	MP0002735_abnormal_chemical_nociception	1.25395946
55	MP0001502_abnormal_circadian_rhythm	1.23126471
56	MP0002184_abnormal_innervation	1.22813703
57	MP0002734_abnormal_mechanical_nocicepti	1.22306349
58	MP0005187_abnormal_penis_morphology	1.20302776
59	MP0008877_abnormal_DNA_methylation	1.17782710
60	MP0001486_abnormal_startle_reflex	1.16000298
61	MP0002160_abnormal_reproductive_system	1.13631557
62	MP0001440_abnormal_grooming_behavior	1.11605483
63	MP0003942_abnormal_urinary_system	1.09881441
64	MP0003938_abnormal_ear_development	1.09855761
65	MP0008995_early_reproductive_senescence	1.08671545
66	MP0002882_abnormal_neuron_morphology	1.05926761
67	MP0003119_abnormal_digestive_system	1.03494398
68	MP0003385_abnormal_body_wall	1.02980901
69	MP0000026_abnormal_inner_ear	1.00593862
70	MP0002752_abnormal_somatic_nervous	1.00049028
71	MP0002067_abnormal_sensory_capabilities	0.99793302
72	MP0003186_abnormal_redox_activity	0.97908702
73	MP0004742_abnormal_vestibular_system	0.95940267
74	MP0003878_abnormal_ear_physiology	0.95418366
75	MP0005377_hearing/vestibular/ear_phenot	0.95418366
76	MP0009278_abnormal_bone_marrow	0.94292664
77	MP0002152_abnormal_brain_morphology	0.93457541
78	MP0002095_abnormal_skin_pigmentation	0.92064669
79	MP0003011_delayed_dark_adaptation	0.92040290
80	MP0004811_abnormal_neuron_physiology	0.91906342
81	MP0006035_abnormal_mitochondrial_morpho	0.90913646
82	MP0008872_abnormal_physiological_respon	0.88076411
83	MP0002638_abnormal_pupillary_reflex	0.86763827
84	MP0008058_abnormal_DNA_repair	0.86276001
85	MP0003861_abnormal_nervous_system	0.86103575
86	MP0001963_abnormal_hearing_physiology	0.83430052
87	MP0000681_abnormal_thyroid_gland	0.82214168
88	MP0006036_abnormal_mitochondrial_physio	0.81534735
89	MP0003879_abnormal_hair_cell	0.80582246
90	MP0003136_yellow_coat_color	0.80376738
91	MP0005379_endocrine/exocrine_gland_phen	0.79882587
92	MP0005551_abnormal_eye_electrophysiolog	0.79031641
93	MP0000566_synostosis	0.78372290
94	MP0005389_reproductive_system_phenotype	0.78213693
95	MP0006072_abnormal_retinal_apoptosis	0.78037718
96	MP0003315_abnormal_perineum_morphology	0.77796607
97	MP0000372_irregular_coat_pigmentation	0.76417556
98	MP0002066_abnormal_motor_capabilities/c	0.75913505
99	MP0001270_distended_abdomen	0.73550752
100	MP0002210_abnormal_sex_determination	0.72477477

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.69238458
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.56954495
3	Myokymia (HP:0002411)	4.24469903
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.09799017
5	Acute encephalopathy (HP:0006846)	4.03041902
6	Mitochondrial inheritance (HP:0001427)	4.00862320
7	Abnormal number of erythroid precursors (HP:0012131)	3.80550016
8	3-Methylglutaconic aciduria (HP:0003535)	3.69949447
9	Progressive macrocephaly (HP:0004481)	3.67677653
10	Hyperthyroidism (HP:0000836)	3.57009265
11	Increased CSF lactate (HP:0002490)	3.49997873
12	Hepatocellular necrosis (HP:0001404)	3.48005701
13	Reticulocytopenia (HP:0001896)	3.46553872
14	Truncus arteriosus (HP:0001660)	3.37786410
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.10580011
16	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.10580011
17	Cerebral edema (HP:0002181)	2.98181289
18	Double outlet right ventricle (HP:0001719)	2.95999495
19	Congenital malformation of the right heart (HP:0011723)	2.95999495
20	Hepatic necrosis (HP:0002605)	2.95545150
21	Rib fusion (HP:0000902)	2.73594421
22	Macrocytic anemia (HP:0001972)	2.67324385
23	Cerebral hypomyelination (HP:0006808)	2.66929693
24	Increased intramyocellular lipid droplets (HP:0012240)	2.61842719
25	Pallor (HP:0000980)	2.59290486
26	Pancreatic fibrosis (HP:0100732)	2.58953774
27	Muscle fiber atrophy (HP:0100295)	2.57315109
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.53279400
29	Increased hepatocellular lipid droplets (HP:0006565)	2.50880709
30	Broad distal phalanx of finger (HP:0009836)	2.49625627
31	Lactic acidosis (HP:0003128)	2.44408850
32	Colon cancer (HP:0003003)	2.44229575
33	Gait imbalance (HP:0002141)	2.42976569
34	Abnormality of the aortic arch (HP:0012303)	2.38885720
35	CNS hypomyelination (HP:0003429)	2.37528021
36	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.33584386
37	Type 2 muscle fiber atrophy (HP:0003554)	2.33432571
38	Sclerocornea (HP:0000647)	2.30656378
39	Respiratory failure (HP:0002878)	2.29354459
40	Microvesicular hepatic steatosis (HP:0001414)	2.26280331
41	Abnormality of the labia minora (HP:0012880)	2.24332412
42	Increased serum lactate (HP:0002151)	2.24195454
43	Abnormality of midbrain morphology (HP:0002418)	2.22874474
44	Molar tooth sign on MRI (HP:0002419)	2.22874474
45	Medial flaring of the eyebrow (HP:0010747)	2.22371678
46	Optic disc pallor (HP:0000543)	2.21800684
47	Microretrognathia (HP:0000308)	2.21055171
48	Leukodystrophy (HP:0002415)	2.20958552
49	Lipid accumulation in hepatocytes (HP:0006561)	2.20352969
50	Congenital primary aphakia (HP:0007707)	2.20141830
51	Abnormal number of incisors (HP:0011064)	2.19628634
52	Increased muscle lipid content (HP:0009058)	2.17161772
53	Exercise intolerance (HP:0003546)	2.16864939
54	Renal Fanconi syndrome (HP:0001994)	2.14142036
55	Emotional lability (HP:0000712)	2.13187121
56	Polyphagia (HP:0002591)	2.12547642
57	True hermaphroditism (HP:0010459)	2.12287660
58	Epileptic encephalopathy (HP:0200134)	2.11767612
59	Abnormality of cochlea (HP:0000375)	2.09688101
60	Anomalous pulmonary venous return (HP:0010772)	2.04437831
61	Septo-optic dysplasia (HP:0100842)	2.02050394
62	X-linked dominant inheritance (HP:0001423)	2.00717080
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.97917887
64	Depressed nasal ridge (HP:0000457)	1.97695964
65	Nephrogenic diabetes insipidus (HP:0009806)	1.95427415
66	Anophthalmia (HP:0000528)	1.91703437
67	Pancreatic cysts (HP:0001737)	1.90142109
68	Abnormality of DNA repair (HP:0003254)	1.89670854
69	Nephronophthisis (HP:0000090)	1.88871342
70	Methylmalonic aciduria (HP:0012120)	1.87582681
71	Stenosis of the external auditory canal (HP:0000402)	1.86633835
72	Oligodactyly (HP:0012165)	1.85499604
73	Horseshoe kidney (HP:0000085)	1.83272965
74	Optic nerve coloboma (HP:0000588)	1.81293343
75	Type II lissencephaly (HP:0007260)	1.81232791
76	Anencephaly (HP:0002323)	1.80278556
77	Abnormal hemoglobin (HP:0011902)	1.79626166
78	Hyperglycinemia (HP:0002154)	1.78405130
79	Lethargy (HP:0001254)	1.78121714
80	Abnormality of reticulocytes (HP:0004312)	1.76150667
81	Occipital encephalocele (HP:0002085)	1.74384944
82	Methylmalonic acidemia (HP:0002912)	1.73721515
83	Adrenal hypoplasia (HP:0000835)	1.71582825
84	Aplasia/Hypoplasia of the patella (HP:0006498)	1.71570656
85	Aganglionic megacolon (HP:0002251)	1.71385507
86	Abnormality of magnesium homeostasis (HP:0004921)	1.71023396
87	Morphological abnormality of the inner ear (HP:0011390)	1.69125793
88	Maternal diabetes (HP:0009800)	1.68907152
89	Specific learning disability (HP:0001328)	1.68598524
90	Lissencephaly (HP:0001339)	1.68479034
91	Down-sloping shoulders (HP:0200021)	1.67829894
92	Ulnar claw (HP:0001178)	1.67025290
93	Abnormality of the pulmonary veins (HP:0011718)	1.65976999
94	Hypoplastic left heart (HP:0004383)	1.65137865
95	Patellar aplasia (HP:0006443)	1.64984994
96	Poor suck (HP:0002033)	1.63531372
97	Hypoparathyroidism (HP:0000829)	1.62543581
98	Retinal dysplasia (HP:0007973)	1.60865567
99	Delusions (HP:0000746)	1.60146144
100	Vaginal atresia (HP:0000148)	1.59289503

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.25371695
2	BCKDK	3.92935733
3	STK16	2.97663532
4	MAP2K7	2.61295792
5	MAP3K4	2.41432054
6	DYRK2	2.38900004
7	ADRBK2	2.24150160
8	CDC7	2.14799323
9	MAP4K2	2.05165113
10	PLK4	1.99603413
11	EPHA4	1.89450045
12	NTRK2	1.87838544
13	BRAF	1.84213538
14	TESK2	1.83503760
15	PAK6	1.64717276
16	CASK	1.62421629
17	VRK2	1.59949210
18	GRK1	1.52817753
19	PINK1	1.52154809
20	AURKA	1.49933200
21	KDR	1.46293067
22	CSNK1G3	1.44812140
23	CDK19	1.40467772
24	DYRK3	1.40097411
25	MARK1	1.36794662
26	CDK8	1.36475715
27	PRKD3	1.36415310
28	NTRK3	1.32944568
29	WNK3	1.26931731
30	PDK2	1.23444881
31	PRKCG	1.21520481
32	CSNK1G2	1.20475183
33	LRRK2	1.16684092
34	MAP3K11	1.13052899
35	LIMK1	1.09684656
36	CSNK1A1L	1.07661126
37	CAMKK2	1.06912348
38	DYRK1B	1.05374937
39	ARAF	1.04998544
40	ABL2	1.04473689
41	BUB1	1.02689021
42	CSNK1G1	0.99347516
43	PIM2	0.98440351
44	TLK1	0.96328951
45	MAP2K4	0.95874903
46	MAPK13	0.95114458
47	RPS6KA5	0.92962842
48	CDK11A	0.88197384
49	CDK14	0.86991380
50	BRSK1	0.86546908
51	UHMK1	0.86264309
52	NME1	0.84852689
53	CDK15	0.84162902
54	TIE1	0.81367387
55	VRK1	0.81020350
56	MAP2K2	0.80398932
57	SIK2	0.79902724
58	CAMKK1	0.78655166
59	MINK1	0.77988041
60	CAMK1	0.77751316
61	SGK494	0.77644565
62	SGK223	0.77644565
63	MAP3K9	0.76805752
64	CDK18	0.76758922
65	CHEK2	0.75943115
66	PKN1	0.74578545
67	GRK5	0.74153303
68	NTRK1	0.73307691
69	NUAK1	0.70119190
70	ATR	0.66470166
71	CAMK4	0.65909348
72	PLK1	0.65154372
73	CSNK2A2	0.64893070
74	AURKB	0.63096011
75	AKT3	0.60346139
76	ADRBK1	0.59361030
77	INSRR	0.58986573
78	AKT2	0.57933633
79	WNK4	0.57076717
80	CSNK2A1	0.55656877
81	SRPK1	0.55583692
82	CDK5	0.55006352
83	PLK2	0.54334693
84	ZAK	0.54072763
85	RPS6KA4	0.52812185
86	CAMK2G	0.52791300
87	CAMK2B	0.52255982
88	DYRK1A	0.52072610
89	TYRO3	0.51728756
90	STK11	0.50534688
91	EPHB2	0.49707617
92	CSNK1E	0.49090722
93	PRKCI	0.47895684
94	PAK3	0.46810617
95	NEK1	0.44204170
96	PAK1	0.43971831
97	PRKACA	0.43803191
98	CAMK2A	0.42200604
99	RPS6KA2	0.42181456
100	CSNK1A1	0.41916173

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.36691031
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.42250161
3	Parkinsons disease_Homo sapiens_hsa05012	3.75444087
4	Sulfur relay system_Homo sapiens_hsa04122	3.07536114
5	Huntingtons disease_Homo sapiens_hsa05016	2.74781187
6	RNA polymerase_Homo sapiens_hsa03020	2.71771657
7	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.70352269
8	Alzheimers disease_Homo sapiens_hsa05010	2.63135728
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.48983128
10	DNA replication_Homo sapiens_hsa03030	2.40571255
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28694930
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.25812671
13	Base excision repair_Homo sapiens_hsa03410	2.13813943
14	Mismatch repair_Homo sapiens_hsa03430	2.07565717
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.01819918
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.99564423
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.69582596
18	Folate biosynthesis_Homo sapiens_hsa00790	1.60046019
19	One carbon pool by folate_Homo sapiens_hsa00670	1.59636001
20	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.51271768
21	Steroid biosynthesis_Homo sapiens_hsa00100	1.50964310
22	Homologous recombination_Homo sapiens_hsa03440	1.46974568
23	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.42194216
24	Nicotine addiction_Homo sapiens_hsa05033	1.39801686
25	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.32594926
26	Phenylalanine metabolism_Homo sapiens_hsa00360	1.28931165
27	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20562419
28	Spliceosome_Homo sapiens_hsa03040	1.16802320
29	Purine metabolism_Homo sapiens_hsa00230	1.15801665
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.12269535
31	Phototransduction_Homo sapiens_hsa04744	1.09975674
32	Proteasome_Homo sapiens_hsa03050	1.05182975
33	Fatty acid elongation_Homo sapiens_hsa00062	1.00351991
34	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99005061
35	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.96388049
36	Basal cell carcinoma_Homo sapiens_hsa05217	0.92678057
37	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.90187371
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.89247394
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.86706854
40	RNA degradation_Homo sapiens_hsa03018	0.86205238
41	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83975538
42	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.83838211
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83554670
44	RNA transport_Homo sapiens_hsa03013	0.83116142
45	Protein export_Homo sapiens_hsa03060	0.81906911
46	Pyruvate metabolism_Homo sapiens_hsa00620	0.81271017
47	Metabolic pathways_Homo sapiens_hsa01100	0.81110026
48	GABAergic synapse_Homo sapiens_hsa04727	0.79372437
49	Peroxisome_Homo sapiens_hsa04146	0.76906052
50	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.74548776
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.69200133
52	Morphine addiction_Homo sapiens_hsa05032	0.68559324
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.67678618
54	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.67165008
55	Glutathione metabolism_Homo sapiens_hsa00480	0.65326773
56	Alcoholism_Homo sapiens_hsa05034	0.65003556
57	Tyrosine metabolism_Homo sapiens_hsa00350	0.63663211
58	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.62732404
59	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.60945704
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56741605
61	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.56307260
62	Glutamatergic synapse_Homo sapiens_hsa04724	0.56039915
63	Cocaine addiction_Homo sapiens_hsa05030	0.54290439
64	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.54225702
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53945338
66	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.50567946
67	Insulin secretion_Homo sapiens_hsa04911	0.48688498
68	Carbon metabolism_Homo sapiens_hsa01200	0.47788255
69	Propanoate metabolism_Homo sapiens_hsa00640	0.47708672
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.47411367
71	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.46128025
72	Regulation of autophagy_Homo sapiens_hsa04140	0.43615966
73	Circadian entrainment_Homo sapiens_hsa04713	0.43060364
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42805050
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41230868
76	Taste transduction_Homo sapiens_hsa04742	0.40623305
77	Olfactory transduction_Homo sapiens_hsa04740	0.40523956
78	Sulfur metabolism_Homo sapiens_hsa00920	0.40298733
79	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39903698
80	Hippo signaling pathway_Homo sapiens_hsa04390	0.37548081
81	Basal transcription factors_Homo sapiens_hsa03022	0.36712301
82	Butanoate metabolism_Homo sapiens_hsa00650	0.35220923
83	Notch signaling pathway_Homo sapiens_hsa04330	0.34619375
84	Cholinergic synapse_Homo sapiens_hsa04725	0.30617547
85	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29040543
86	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.28952576
87	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28439383
88	Axon guidance_Homo sapiens_hsa04360	0.25501424
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.24258650
90	Melanogenesis_Homo sapiens_hsa04916	0.22081506
91	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.21540425
92	Amphetamine addiction_Homo sapiens_hsa05031	0.21077306
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.20628400
94	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.18890872
95	Pentose phosphate pathway_Homo sapiens_hsa00030	0.18829138
96	beta-Alanine metabolism_Homo sapiens_hsa00410	0.18786034
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.18319322
98	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.17864682
99	Cell cycle_Homo sapiens_hsa04110	0.17747695
100	Tryptophan metabolism_Homo sapiens_hsa00380	0.17233123

C19ORF81

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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