ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.50269148
2	purine nucleobase biosynthetic process (GO:0009113)	5.41355098
3	DNA methylation involved in gamete generation (GO:0043046)	5.20687437
4	nucleobase biosynthetic process (GO:0046112)	5.10102461
5	IMP biosynthetic process (GO:0006188)	5.07134827
6	meiotic chromosome segregation (GO:0045132)	5.01089786
7	nuclear pore complex assembly (GO:0051292)	4.84097797
8	regulation of posttranscriptional gene silencing (GO:0060147)	4.64997259
9	regulation of gene silencing by miRNA (GO:0060964)	4.64997259
10	regulation of gene silencing by RNA (GO:0060966)	4.64997259
11	somatic diversification of immune receptors via somatic mutation (GO:0002566)	4.41993630
12	somatic hypermutation of immunoglobulin genes (GO:0016446)	4.41993630
13	DNA replication checkpoint (GO:0000076)	4.35385952
14	IMP metabolic process (GO:0046040)	4.32772148
15	chromatin remodeling at centromere (GO:0031055)	4.30854013
16	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.28517805
17	CENP-A containing nucleosome assembly (GO:0034080)	4.25097237
18	pre-miRNA processing (GO:0031054)	4.14693833
19	histone arginine methylation (GO:0034969)	4.11837195
20	regulation of meiosis I (GO:0060631)	4.07983939
21	nuclear pore organization (GO:0006999)	4.06410483
22	formation of translation preinitiation complex (GO:0001731)	3.93002794
23	resolution of meiotic recombination intermediates (GO:0000712)	3.91691188
24	DNA replication-independent nucleosome assembly (GO:0006336)	3.89000501
25	DNA replication-independent nucleosome organization (GO:0034724)	3.89000501
26	mitotic sister chromatid cohesion (GO:0007064)	3.84203436
27	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.83784582
28	histone exchange (GO:0043486)	3.73572064
29	regulation of uterine smooth muscle contraction (GO:0070472)	3.71677859
30	establishment of integrated proviral latency (GO:0075713)	3.67315976
31	DNA unwinding involved in DNA replication (GO:0006268)	3.66597557
32	negative regulation of gene silencing (GO:0060969)	3.64839580
33	protein complex localization (GO:0031503)	3.64081736
34	regulation of mitochondrial translation (GO:0070129)	3.57840483
35	negative regulation of telomerase activity (GO:0051974)	3.57645127
36	tachykinin receptor signaling pathway (GO:0007217)	3.57347072
37	DNA replication initiation (GO:0006270)	3.55831998
38	heterochromatin organization (GO:0070828)	3.54528842
39	DNA strand elongation involved in DNA replication (GO:0006271)	3.50344216
40	regulation of histone H3-K9 methylation (GO:0051570)	3.49524184
41	peptidyl-arginine omega-N-methylation (GO:0035247)	3.46016734
42	pore complex assembly (GO:0046931)	3.42017452
43	cellular protein complex localization (GO:0034629)	3.37424991
44	DNA strand elongation (GO:0022616)	3.35630019
45	regulation of translational termination (GO:0006449)	3.30743079
46	DNA strand renaturation (GO:0000733)	3.26359188
47	synapsis (GO:0007129)	3.20088876
48	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.19990166
49	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.19990166
50	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.19990166
51	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.19990166
52	negative regulation of sister chromatid segregation (GO:0033046)	3.19990166
53	DNA alkylation (GO:0006305)	3.18876203
54	DNA methylation (GO:0006306)	3.18876203
55	negative regulation of chromosome segregation (GO:0051985)	3.18306249
56	positive regulation of protein homodimerization activity (GO:0090073)	3.17578515
57	mitotic nuclear envelope disassembly (GO:0007077)	3.17258539
58	DNA topological change (GO:0006265)	3.15421960
59	ribosome biogenesis (GO:0042254)	3.11750254
60	negative regulation of mRNA splicing, via spliceosome (GO:0048025)	3.10840027
61	mitotic chromosome condensation (GO:0007076)	3.08523524
62	lysine catabolic process (GO:0006554)	3.08518448
63	lysine metabolic process (GO:0006553)	3.08518448
64	hyperosmotic salinity response (GO:0042538)	3.08378061
65	telomere maintenance via semi-conservative replication (GO:0032201)	3.07561064
66	regulation of mitotic spindle checkpoint (GO:1903504)	3.07541467
67	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.07541467
68	gene silencing by RNA (GO:0031047)	3.07184895
69	DNA replication-dependent nucleosome organization (GO:0034723)	3.06902672
70	DNA replication-dependent nucleosome assembly (GO:0006335)	3.06902672
71	L-serine metabolic process (GO:0006563)	3.06450035
72	protein localization to kinetochore (GO:0034501)	3.05154538
73	mitotic metaphase plate congression (GO:0007080)	3.04783193
74	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.03114512
75	negative regulation of RNA splicing (GO:0033119)	2.99815834
76	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94181267
77	membrane disassembly (GO:0030397)	2.93181576
78	nuclear envelope disassembly (GO:0051081)	2.93181576
79	ATP-dependent chromatin remodeling (GO:0043044)	2.93058015
80	peptidyl-arginine methylation (GO:0018216)	2.91952324
81	peptidyl-arginine N-methylation (GO:0035246)	2.91952324
82	ribosome assembly (GO:0042255)	2.91673596
83	regulation of helicase activity (GO:0051095)	2.90901574
84	negative regulation of mRNA metabolic process (GO:1903312)	2.89794290
85	erythrocyte maturation (GO:0043249)	2.89000361
86	negative regulation of histone methylation (GO:0031061)	2.87766987
87	chromatin assembly or disassembly (GO:0006333)	2.86532090
88	negative regulation of DNA recombination (GO:0045910)	2.86317194
89	mitotic spindle checkpoint (GO:0071174)	2.85338085
90	male meiosis (GO:0007140)	2.84215018
91	mitotic spindle assembly checkpoint (GO:0007094)	2.83449613
92	chaperone-mediated protein transport (GO:0072321)	2.83040737
93	mitochondrial DNA metabolic process (GO:0032042)	2.82880267
94	male meiosis I (GO:0007141)	2.82786807
95	viral mRNA export from host cell nucleus (GO:0046784)	2.80182283
96	proline biosynthetic process (GO:0006561)	2.79233985
97	mitotic recombination (GO:0006312)	2.78318829
98	spindle assembly checkpoint (GO:0071173)	2.78136763
99	negative regulation of mRNA processing (GO:0050686)	2.76848793
100	regulation of translational fidelity (GO:0006450)	2.73503428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.39447342
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.96205587
3	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.40053136
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.22158236
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.01587820
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.93396287
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91157234
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.80831038
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.73811567
10	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.72170953
11	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.72170953
12	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.72170953
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.67111761
14	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.65182458
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.58141655
16	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.50127252
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.42492819
18	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.38135295
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38090792
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.33908291
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.28706412
22	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25259390
23	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.24657586
24	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.21929469
25	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.20503490
26	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.18959670
27	FOXP3_21729870_ChIP-Seq_TREG_Human	2.16992309
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.08792952
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.92803149
30	TTF2_22483619_ChIP-Seq_HELA_Human	1.91707712
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.90255445
32	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.78218172
33	VDR_23849224_ChIP-Seq_CD4+_Human	1.77463246
34	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76441120
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.74137913
36	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.72879416
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.68527186
38	MYC_22102868_ChIP-Seq_BL_Human	1.64703578
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64292142
40	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.63554491
41	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.63073902
42	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.60785563
43	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.57824301
44	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.57207489
45	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.50746036
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.49183388
47	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.44970370
48	AR_21909140_ChIP-Seq_LNCAP_Human	1.44074059
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43983570
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.40998678
51	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.40001406
52	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.37893887
53	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.34579495
54	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.34253362
55	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.32595468
56	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.29562130
57	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.28248034
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28129699
59	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.26811954
60	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26601384
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26347978
62	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.22794996
63	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.21374159
64	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.20325216
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.17809624
66	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16708366
67	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.14560774
68	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.13528986
69	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	1.10585812
70	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10320923
71	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09607095
72	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.08417770
73	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.07515606
74	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.06835192
75	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.06386026
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05298469
77	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.04889607
78	NCOR1_26117541_ChIP-Seq_K562_Human	1.04805603
79	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04334177
80	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.02439815
81	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.02185987
82	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01974717
83	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.01121115
84	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.00999179
85	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.00678186
86	MYC_18940864_ChIP-ChIP_HL60_Human	0.99512283
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.96665575
88	SPI1_23547873_ChIP-Seq_NB4_Human	0.94779364
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.92741057
90	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.91423728
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91171364
92	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.89998815
93	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.89804928
94	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.88971949
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.88503151
96	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.86233525
97	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.81775631
98	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.81745349
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.81633867
100	TCF3_18692474_ChIP-Seq_MESCs_Mouse	0.81094542

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.67242991
2	MP0003693_abnormal_embryo_hatching	4.44392853
3	MP0004957_abnormal_blastocyst_morpholog	4.05977313
4	MP0008058_abnormal_DNA_repair	3.90631198
5	MP0010094_abnormal_chromosome_stability	3.70454997
6	MP0003111_abnormal_nucleus_morphology	3.62614473
7	MP0008057_abnormal_DNA_replication	3.30523195
8	MP0005451_abnormal_body_composition	3.08638168
9	MP0002254_reproductive_system_inflammat	2.83321892
10	MP0003077_abnormal_cell_cycle	2.70714047
11	MP0003941_abnormal_skin_development	2.68200845
12	MP0003806_abnormal_nucleotide_metabolis	2.56091395
13	MP0003718_maternal_effect	2.46442852
14	MP0008007_abnormal_cellular_replicative	2.28105420
15	MP0008932_abnormal_embryonic_tissue	2.25666678
16	MP0001730_embryonic_growth_arrest	2.24616998
17	MP0006035_abnormal_mitochondrial_morpho	2.21784549
18	MP0008995_early_reproductive_senescence	2.19884205
19	MP0003567_abnormal_fetal_cardiomyocyte	2.15521536
20	MP0003890_abnormal_embryonic-extraembry	2.11918565
21	MP0003786_premature_aging	2.07357820
22	MP0002210_abnormal_sex_determination	2.00164844
23	MP0002396_abnormal_hematopoietic_system	1.94246689
24	MP0001188_hyperpigmentation	1.89240587
25	MP0001929_abnormal_gametogenesis	1.84600733
26	MP0009278_abnormal_bone_marrow	1.79944310
27	MP0009672_abnormal_birth_weight	1.74956687
28	MP0001145_abnormal_male_reproductive	1.69655575
29	MP0000350_abnormal_cell_proliferation	1.66591256
30	MP0000703_abnormal_thymus_morphology	1.56901585
31	MP0000313_abnormal_cell_death	1.56211269
32	MP0001672_abnormal_embryogenesis/_devel	1.54062522
33	MP0005380_embryogenesis_phenotype	1.54062522
34	MP0000653_abnormal_sex_gland	1.52448372
35	MP0006292_abnormal_olfactory_placode	1.52014136
36	MP0002080_prenatal_lethality	1.47608893
37	MP0005083_abnormal_biliary_tract	1.46611136
38	MP0002085_abnormal_embryonic_tissue	1.46530466
39	MP0003698_abnormal_male_reproductive	1.46272214
40	MP0001293_anophthalmia	1.43955435
41	MP0001697_abnormal_embryo_size	1.42901520
42	MP0003763_abnormal_thymus_physiology	1.35217015
43	MP0002084_abnormal_developmental_patter	1.33406290
44	MP0000490_abnormal_crypts_of	1.32235220
45	MP0010307_abnormal_tumor_latency	1.30879441
46	MP0003984_embryonic_growth_retardation	1.29771214
47	MP0003123_paternal_imprinting	1.28203145
48	MP0002088_abnormal_embryonic_growth/wei	1.28165703
49	MP0003119_abnormal_digestive_system	1.27503669
50	MP0009697_abnormal_copulation	1.27183081
51	MP0002398_abnormal_bone_marrow	1.20679942
52	MP0008260_abnormal_autophagy	1.16167083
53	MP0002722_abnormal_immune_system	1.15400036
54	MP0002086_abnormal_extraembryonic_tissu	1.12767260
55	MP0006036_abnormal_mitochondrial_physio	1.12753871
56	MP0000678_abnormal_parathyroid_gland	1.12048454
57	MP0004133_heterotaxia	1.11353433
58	MP0002796_impaired_skin_barrier	1.10879286
59	MP0005671_abnormal_response_to	1.08662170
60	MP0002132_abnormal_respiratory_system	1.07417441
61	MP0000689_abnormal_spleen_morphology	1.05396334
62	MP0001119_abnormal_female_reproductive	1.04263307
63	MP0002161_abnormal_fertility/fecundity	1.03717794
64	MP0009333_abnormal_splenocyte_physiolog	1.01464177
65	MP0003221_abnormal_cardiomyocyte_apopto	1.00231082
66	MP0004233_abnormal_muscle_weight	0.98843074
67	MP0003699_abnormal_female_reproductive	0.96921095
68	MP0009703_decreased_birth_body	0.95351121
69	MP0004197_abnormal_fetal_growth/weight/	0.94391121
70	MP0005410_abnormal_fertilization	0.93713986
71	MP0002019_abnormal_tumor_incidence	0.89843454
72	MP0002429_abnormal_blood_cell	0.88022950
73	MP0003937_abnormal_limbs/digits/tail_de	0.84769505
74	MP0004145_abnormal_muscle_electrophysio	0.83079287
75	MP0002102_abnormal_ear_morphology	0.82394140
76	MP0000358_abnormal_cell_content/	0.78164833
77	MP0000716_abnormal_immune_system	0.74749686
78	MP0003183_abnormal_peptide_metabolism	0.74128312
79	MP0002751_abnormal_autonomic_nervous	0.70191677
80	MP0008770_decreased_survivor_rate	0.67992749
81	MP0005377_hearing/vestibular/ear_phenot	0.64342698
82	MP0003878_abnormal_ear_physiology	0.64342698
83	MP0005397_hematopoietic_system_phenotyp	0.63658266
84	MP0001545_abnormal_hematopoietic_system	0.63658266
85	MP0003861_abnormal_nervous_system	0.62887999
86	MP0001819_abnormal_immune_cell	0.62491261
87	MP0002111_abnormal_tail_morphology	0.62001999
88	MP0003121_genomic_imprinting	0.60845411
89	MP0001915_intracranial_hemorrhage	0.60056786
90	MP0002277_abnormal_respiratory_mucosa	0.59806089
91	MP0002420_abnormal_adaptive_immunity	0.59029878
92	MP0005075_abnormal_melanosome_morpholog	0.58075849
93	MP0005076_abnormal_cell_differentiation	0.57564350
94	MP0000537_abnormal_urethra_morphology	0.56786023
95	MP0000631_abnormal_neuroendocrine_gland	0.56687916
96	MP0004019_abnormal_vitamin_homeostasis	0.54928874
97	MP0006082_CNS_inflammation	0.53498933
98	MP0002723_abnormal_immune_serum	0.53014899
99	MP0001286_abnormal_eye_development	0.52962954
100	MP0001800_abnormal_humoral_immune	0.52808304

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.55517530
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	4.39300925
3	Homocystinuria (HP:0002156)	3.95220988
4	Abnormality of homocysteine metabolism (HP:0010919)	3.95220988
5	Chromsome breakage (HP:0040012)	3.92887777
6	Colon cancer (HP:0003003)	3.86122706
7	Premature ovarian failure (HP:0008209)	3.74119595
8	Shoulder girdle muscle weakness (HP:0003547)	3.56171236
9	IgM deficiency (HP:0002850)	3.54478313
10	Sensory axonal neuropathy (HP:0003390)	3.39502387
11	Agnosia (HP:0010524)	3.28237261
12	Dysphonia (HP:0001618)	3.25125768
13	Birth length less than 3rd percentile (HP:0003561)	3.24103221
14	Progressive external ophthalmoplegia (HP:0000590)	3.17832003
15	Reticulocytopenia (HP:0001896)	3.14684828
16	Ependymoma (HP:0002888)	2.88779238
17	Abnormal gallbladder physiology (HP:0012438)	2.76389872
18	Cholecystitis (HP:0001082)	2.76389872
19	Microvesicular hepatic steatosis (HP:0001414)	2.71452895
20	Abnormality of the preputium (HP:0100587)	2.71150510
21	Osteomalacia (HP:0002749)	2.69382171
22	Pallor (HP:0000980)	2.69337841
23	Abnormal hair whorl (HP:0010721)	2.68225059
24	Gonadotropin excess (HP:0000837)	2.66503190
25	Meckel diverticulum (HP:0002245)	2.64215660
26	Testicular atrophy (HP:0000029)	2.55871355
27	Progressive muscle weakness (HP:0003323)	2.47559119
28	Abnormality of chromosome stability (HP:0003220)	2.44713957
29	Absent radius (HP:0003974)	2.43442399
30	Rhabdomyosarcoma (HP:0002859)	2.41404106
31	Abnormality of the ileum (HP:0001549)	2.41278786
32	Combined immunodeficiency (HP:0005387)	2.40129682
33	Abnormality of the salivary glands (HP:0010286)	2.38530168
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.34821486
35	Urethral obstruction (HP:0000796)	2.31395181
36	Cellular immunodeficiency (HP:0005374)	2.29070943
37	Abnormality of methionine metabolism (HP:0010901)	2.28421218
38	Stenosis of the external auditory canal (HP:0000402)	2.27174198
39	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.24471360
40	Aplasia involving forearm bones (HP:0009822)	2.23660204
41	Absent forearm bone (HP:0003953)	2.23660204
42	Multiple enchondromatosis (HP:0005701)	2.19485561
43	Upper motor neuron abnormality (HP:0002127)	2.17857479
44	Abnormality of B cell number (HP:0010975)	2.15063539
45	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.14977982
46	Abnormal lung lobation (HP:0002101)	2.14895471
47	Thrombocytosis (HP:0001894)	2.12450899
48	Lymphoma (HP:0002665)	2.10952245
49	Impulsivity (HP:0100710)	2.10871849
50	Impaired proprioception (HP:0010831)	2.10539743
51	Ectopic kidney (HP:0000086)	2.09746127
52	Duplication of thumb phalanx (HP:0009942)	2.09590200
53	Hypoplasia of the pons (HP:0012110)	2.09382765
54	Diastasis recti (HP:0001540)	2.07544273
55	B lymphocytopenia (HP:0010976)	2.07024126
56	Cortical dysplasia (HP:0002539)	2.06598500
57	IgG deficiency (HP:0004315)	2.06587387
58	Rimmed vacuoles (HP:0003805)	2.05262150
59	Abnormality of reticulocytes (HP:0004312)	2.04487171
60	Abnormal number of erythroid precursors (HP:0012131)	2.02916985
61	Nephroblastoma (Wilms tumor) (HP:0002667)	2.02190461
62	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.01791337
63	Hyperglycinemia (HP:0002154)	2.00423800
64	Abnormality of the duodenum (HP:0002246)	1.99945181
65	Hyperglycinuria (HP:0003108)	1.99436034
66	Triphalangeal thumb (HP:0001199)	1.98451916
67	Medulloblastoma (HP:0002885)	1.94031841
68	Rectal fistula (HP:0100590)	1.94010217
69	Rectovaginal fistula (HP:0000143)	1.94010217
70	Abnormality of serum amino acid levels (HP:0003112)	1.93170301
71	Abnormality of cells of the erythroid lineage (HP:0012130)	1.92330839
72	Scotoma (HP:0000575)	1.92091383
73	Duodenal stenosis (HP:0100867)	1.91617517
74	Small intestinal stenosis (HP:0012848)	1.91617517
75	Seborrheic dermatitis (HP:0001051)	1.91237554
76	Abnormality of the pons (HP:0007361)	1.91050518
77	Severe combined immunodeficiency (HP:0004430)	1.89310081
78	Volvulus (HP:0002580)	1.88610090
79	Amyotrophic lateral sclerosis (HP:0007354)	1.88077571
80	Macrocytic anemia (HP:0001972)	1.87967896
81	Abnormality of the renal collecting system (HP:0004742)	1.87587885
82	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87362774
83	Abnormality of glycine metabolism (HP:0010895)	1.87362774
84	Intestinal fistula (HP:0100819)	1.87358190
85	Spastic diplegia (HP:0001264)	1.87210552
86	Hypergonadotropic hypogonadism (HP:0000815)	1.86911088
87	Elevated erythrocyte sedimentation rate (HP:0003565)	1.85507944
88	Myelodysplasia (HP:0002863)	1.84923792
89	Horseshoe kidney (HP:0000085)	1.84848998
90	Septo-optic dysplasia (HP:0100842)	1.82582890
91	Abnormal biliary tract physiology (HP:0012439)	1.81645995
92	Bile duct proliferation (HP:0001408)	1.81645995
93	Choanal atresia (HP:0000453)	1.81645044
94	Cortical visual impairment (HP:0100704)	1.80900138
95	Embryonal renal neoplasm (HP:0011794)	1.80500555
96	Duplicated collecting system (HP:0000081)	1.79030680
97	Abnormality of the lower motor neuron (HP:0002366)	1.76923041
98	Increased nuchal translucency (HP:0010880)	1.76316578
99	Amaurosis fugax (HP:0100576)	1.76006262
100	Vaginal fistula (HP:0004320)	1.75866165

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	3.42712727
2	PRPF4B	3.42149792
3	TTK	3.39461168
4	PASK	2.86235897
5	MUSK	2.78712423
6	TNIK	2.75330434
7	CDK12	2.65098404
8	ZAK	2.62715950
9	BUB1	2.61714607
10	VRK2	2.52764391
11	SCYL2	2.41084721
12	SRPK1	2.35281455
13	TAF1	2.26554501
14	PLK4	2.17225384
15	PBK	2.14896657
16	MKNK2	2.09367430
17	RIPK4	2.06559260
18	EIF2AK1	1.97331314
19	MKNK1	1.93891041
20	TAOK2	1.93733164
21	SMG1	1.91526746
22	TSSK6	1.88151037
23	PLK3	1.61052989
24	CDK19	1.57889466
25	ACVR1B	1.54007424
26	BRD4	1.51528646
27	TESK2	1.50962763
28	NEK1	1.50679637
29	STK4	1.44583262
30	ALK	1.42848532
31	MAP3K10	1.41417206
32	MST4	1.35464674
33	NUAK1	1.33250649
34	PLK1	1.29737245
35	EIF2AK3	1.29625012
36	VRK1	1.28871750
37	KDR	1.23673747
38	NME1	1.20474032
39	YES1	1.15199337
40	STK3	1.11413163
41	BRSK2	1.10402218
42	CSK	1.09930288
43	TEC	1.07790398
44	FES	1.07168759
45	CHEK1	1.05806807
46	EEF2K	1.03512744
47	BRSK1	1.03159552
48	DYRK2	0.96971409
49	CLK1	0.96841816
50	ATR	0.96102045
51	BMX	0.88825445
52	WEE1	0.87908506
53	MAP3K8	0.85690217
54	STK24	0.85018433
55	DYRK3	0.79896749
56	CHEK2	0.79455490
57	FGR	0.79172642
58	LATS1	0.75771710
59	TYRO3	0.74867001
60	ATM	0.74241518
61	PIM1	0.72607258
62	TLK1	0.71742791
63	BTK	0.71577092
64	NEK2	0.67908961
65	NLK	0.65739233
66	CDK4	0.62902629
67	BMPR1B	0.62356297
68	JAK3	0.61933824
69	CDK7	0.60351682
70	PIK3CG	0.58160569
71	CDK2	0.58006992
72	KSR2	0.56120864
73	ITK	0.55567054
74	CDK1	0.54746876
75	AURKB	0.54603446
76	MAP4K1	0.51781964
77	WNK1	0.51779682
78	CSNK2A1	0.50947162
79	CSNK2A2	0.49937669
80	LCK	0.48781749
81	MATK	0.48683073
82	CDK9	0.47470634
83	WNK3	0.45761039
84	WNK4	0.40254568
85	PAK1	0.38426502
86	PRKDC	0.36153357
87	ERN1	0.36081884
88	BLK	0.33114702
89	RPS6KA1	0.31342961
90	LMTK2	0.29948291
91	PAK4	0.29768258
92	DMPK	0.29328043
93	FGFR1	0.25930166
94	AURKA	0.25454767
95	EIF2AK2	0.24547884
96	DYRK1A	0.23808496
97	PRKG2	0.23093932
98	HCK	0.22808205
99	RPS6KB2	0.22765227
100	OXSR1	0.22399813

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Mismatch repair_Homo sapiens_hsa03430	4.62949093
2	DNA replication_Homo sapiens_hsa03030	4.26950609
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.73583568
4	Homologous recombination_Homo sapiens_hsa03440	3.38755105
5	Proteasome_Homo sapiens_hsa03050	3.18545425
6	Base excision repair_Homo sapiens_hsa03410	3.02279028
7	Spliceosome_Homo sapiens_hsa03040	3.01341005
8	RNA transport_Homo sapiens_hsa03013	2.81039843
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.74904304
10	One carbon pool by folate_Homo sapiens_hsa00670	2.72313310
11	Ribosome_Homo sapiens_hsa03010	2.59174814
12	Folate biosynthesis_Homo sapiens_hsa00790	2.42062697
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.40192302
14	Cell cycle_Homo sapiens_hsa04110	2.16926258
15	Selenocompound metabolism_Homo sapiens_hsa00450	2.14934804
16	Primary immunodeficiency_Homo sapiens_hsa05340	2.13837419
17	RNA polymerase_Homo sapiens_hsa03020	1.99963576
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.98178112
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.92888118
20	Basal transcription factors_Homo sapiens_hsa03022	1.92651351
21	RNA degradation_Homo sapiens_hsa03018	1.84898851
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.81185784
23	Non-homologous end-joining_Homo sapiens_hsa03450	1.67628524
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.60536030
25	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.50577570
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.43498433
27	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.35179241
28	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.23584833
29	Protein export_Homo sapiens_hsa03060	1.15574853
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.09975780
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.09633480
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01590317
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.01202019
34	Purine metabolism_Homo sapiens_hsa00230	0.98747925
35	Thyroid cancer_Homo sapiens_hsa05216	0.98304623
36	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.95188351
37	Antigen processing and presentation_Homo sapiens_hsa04612	0.95088577
38	Pyruvate metabolism_Homo sapiens_hsa00620	0.90338945
39	Huntingtons disease_Homo sapiens_hsa05016	0.90028836
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88169324
41	Pentose phosphate pathway_Homo sapiens_hsa00030	0.86377108
42	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.86151785
43	Oocyte meiosis_Homo sapiens_hsa04114	0.85969746
44	Carbon metabolism_Homo sapiens_hsa01200	0.84031073
45	Parkinsons disease_Homo sapiens_hsa05012	0.82977581
46	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.80765101
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.76095129
48	Lysine degradation_Homo sapiens_hsa00310	0.74902687
49	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70379538
50	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.69447116
51	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68550278
52	Colorectal cancer_Homo sapiens_hsa05210	0.66786763
53	Herpes simplex infection_Homo sapiens_hsa05168	0.64423969
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.63847883
55	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.60118031
56	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58778640
57	Fatty acid elongation_Homo sapiens_hsa00062	0.58652985
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.56199038
59	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53601912
60	Galactose metabolism_Homo sapiens_hsa00052	0.52165223
61	p53 signaling pathway_Homo sapiens_hsa04115	0.51120495
62	Legionellosis_Homo sapiens_hsa05134	0.45826246
63	Regulation of autophagy_Homo sapiens_hsa04140	0.45457182
64	Viral myocarditis_Homo sapiens_hsa05416	0.44320532
65	Acute myeloid leukemia_Homo sapiens_hsa05221	0.43348603
66	Apoptosis_Homo sapiens_hsa04210	0.42975394
67	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.42347541
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41572371
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41113986
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.40770819
71	Shigellosis_Homo sapiens_hsa05131	0.37301754
72	HTLV-I infection_Homo sapiens_hsa05166	0.33794584
73	Adherens junction_Homo sapiens_hsa04520	0.33374775
74	Measles_Homo sapiens_hsa05162	0.31800564
75	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.31494642
76	Metabolic pathways_Homo sapiens_hsa01100	0.31463055
77	Wnt signaling pathway_Homo sapiens_hsa04310	0.30281791
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28564869
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27161023
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.25785672
81	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.24970878
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.24795916
83	Propanoate metabolism_Homo sapiens_hsa00640	0.23799079
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22990033
85	Endometrial cancer_Homo sapiens_hsa05213	0.22042466
86	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.21867065
87	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.21154988
88	Sulfur relay system_Homo sapiens_hsa04122	0.20124221
89	Melanoma_Homo sapiens_hsa05218	0.19045641
90	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.15373120
91	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.15055048
92	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.14365623
93	Glutathione metabolism_Homo sapiens_hsa00480	0.13743272
94	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.11913656
95	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.11799436
96	Alzheimers disease_Homo sapiens_hsa05010	0.11502150
97	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.07564008
98	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.06007182
99	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.05070938
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.04429010

C19ORF84

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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