Rank | Gene Set | Z-score |
---|---|---|
1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 7.49356362 |
2 | viral transcription (GO:0019083) | 6.86988326 |
3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 6.83263531 |
4 | ATP synthesis coupled proton transport (GO:0015986) | 6.83263531 |
5 | ribosomal small subunit biogenesis (GO:0042274) | 6.73343349 |
6 | ribosomal small subunit assembly (GO:0000028) | 6.66225008 |
7 | translational termination (GO:0006415) | 6.58749505 |
8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 6.15988576 |
9 | cotranslational protein targeting to membrane (GO:0006613) | 6.06968827 |
10 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 6.05553313 |
11 | protein targeting to ER (GO:0045047) | 6.04496964 |
12 | chaperone-mediated protein transport (GO:0072321) | 6.03148971 |
13 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.89325414 |
14 | maturation of SSU-rRNA (GO:0030490) | 5.83146517 |
15 | translational elongation (GO:0006414) | 5.80858113 |
16 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 5.76705200 |
17 | protein localization to endoplasmic reticulum (GO:0070972) | 5.73108182 |
18 | respiratory electron transport chain (GO:0022904) | 5.71602475 |
19 | electron transport chain (GO:0022900) | 5.61498573 |
20 | viral life cycle (GO:0019058) | 5.17429279 |
21 | cellular protein complex disassembly (GO:0043624) | 5.04635861 |
22 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.99727739 |
23 | translational initiation (GO:0006413) | 4.99460065 |
24 | protein complex biogenesis (GO:0070271) | 4.92672699 |
25 | proteasome assembly (GO:0043248) | 4.85499025 |
26 | translation (GO:0006412) | 4.76146344 |
27 | ribosomal large subunit biogenesis (GO:0042273) | 4.72784939 |
28 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.65196090 |
29 | termination of RNA polymerase III transcription (GO:0006386) | 4.65196090 |
30 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.63465562 |
31 | protein neddylation (GO:0045116) | 4.58403595 |
32 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.53008814 |
33 | NADH dehydrogenase complex assembly (GO:0010257) | 4.53008814 |
34 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.53008814 |
35 | regulation of mitochondrial translation (GO:0070129) | 4.50210909 |
36 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.43338992 |
37 | protein targeting to mitochondrion (GO:0006626) | 4.31169442 |
38 | rRNA modification (GO:0000154) | 4.31155801 |
39 | protein complex disassembly (GO:0043241) | 4.29098371 |
40 | protein targeting to membrane (GO:0006612) | 4.15371112 |
41 | negative regulation of ligase activity (GO:0051352) | 4.10167707 |
42 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.10167707 |
43 | establishment of protein localization to mitochondrion (GO:0072655) | 4.09846538 |
44 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.08904321 |
45 | macromolecular complex disassembly (GO:0032984) | 4.07904974 |
46 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.02593740 |
47 | cellular component biogenesis (GO:0044085) | 4.01444144 |
48 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.98396818 |
49 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.97265639 |
50 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.94283903 |
51 | GTP biosynthetic process (GO:0006183) | 3.92872312 |
52 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.86810805 |
53 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.86708241 |
54 | protein localization to mitochondrion (GO:0070585) | 3.86660195 |
55 | ATP biosynthetic process (GO:0006754) | 3.84896645 |
56 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.83573112 |
57 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.82561732 |
58 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.82561732 |
59 | inner mitochondrial membrane organization (GO:0007007) | 3.81572703 |
60 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.81511694 |
61 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.81511694 |
62 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.81511694 |
63 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.71400026 |
64 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.71400026 |
65 | respiratory chain complex IV assembly (GO:0008535) | 3.70120749 |
66 | hydrogen ion transmembrane transport (GO:1902600) | 3.69350419 |
67 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.69329950 |
68 | pseudouridine synthesis (GO:0001522) | 3.68344383 |
69 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.65364764 |
70 | rRNA processing (GO:0006364) | 3.64657169 |
71 | cytochrome complex assembly (GO:0017004) | 3.63081014 |
72 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.58753759 |
73 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.58181777 |
74 | UTP biosynthetic process (GO:0006228) | 3.57133922 |
75 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 3.53347787 |
76 | spliceosomal snRNP assembly (GO:0000387) | 3.52808312 |
77 | mRNA catabolic process (GO:0006402) | 3.50221840 |
78 | rRNA metabolic process (GO:0016072) | 3.49586565 |
79 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.46461057 |
80 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.46257457 |
81 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.46257457 |
82 | oxidative phosphorylation (GO:0006119) | 3.45798354 |
83 | positive regulation of ligase activity (GO:0051351) | 3.44035063 |
84 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.40141728 |
85 | DNA deamination (GO:0045006) | 3.37503954 |
86 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.36145900 |
87 | base-excision repair, AP site formation (GO:0006285) | 3.35868624 |
88 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.31456197 |
89 | peptidyl-histidine modification (GO:0018202) | 3.30737258 |
90 | mitochondrial transport (GO:0006839) | 3.30581777 |
91 | proton transport (GO:0015992) | 3.24895230 |
92 | rRNA methylation (GO:0031167) | 3.24022985 |
93 | RNA catabolic process (GO:0006401) | 3.22128027 |
94 | nucleoside triphosphate biosynthetic process (GO:0009142) | 3.20550421 |
95 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.17970358 |
96 | establishment of integrated proviral latency (GO:0075713) | 3.17760206 |
97 | hydrogen transport (GO:0006818) | 3.16496985 |
98 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.16248259 |
99 | UTP metabolic process (GO:0046051) | 3.16121111 |
100 | intracellular protein transmembrane import (GO:0044743) | 3.15709126 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.79033933 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.71017348 |
3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.24323484 |
4 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.23501569 |
5 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.89137930 |
6 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.79382406 |
7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.51607423 |
8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.44736809 |
9 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.41748192 |
10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.40130415 |
11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.34433994 |
12 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.16325694 |
13 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.11033070 |
14 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 3.04559122 |
15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.01602996 |
16 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.87433132 |
17 | * XRN2_22483619_ChIP-Seq_HELA_Human | 2.71012156 |
18 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.69930989 |
19 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.63801842 |
20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.60459115 |
21 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.52231754 |
22 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.47515224 |
23 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.41459834 |
24 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.32420681 |
25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.31564943 |
26 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.31347366 |
27 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 2.23965010 |
28 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.23278674 |
29 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.19432875 |
30 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.17675093 |
31 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 2.13367942 |
32 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02173404 |
33 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.98924540 |
34 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.90102690 |
35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.85492130 |
36 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.79056302 |
37 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.64415406 |
38 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.57252855 |
39 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.53600009 |
40 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52251471 |
41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.50639649 |
42 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.48861498 |
43 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.45980173 |
44 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.45924884 |
45 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.43257795 |
46 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.42452202 |
47 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.41707309 |
48 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.41030767 |
49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.40372251 |
50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.40065706 |
51 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.38077300 |
52 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.36804866 |
53 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.34196246 |
54 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.34140901 |
55 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.33974653 |
56 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30240103 |
57 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28540039 |
58 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.28056201 |
59 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.17788355 |
60 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.17419889 |
61 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.16993469 |
62 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.15848889 |
63 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.15235382 |
64 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.14993856 |
65 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.11957833 |
66 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.10708696 |
67 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.09941950 |
68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.09276294 |
69 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.08831068 |
70 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.08390303 |
71 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.07134267 |
72 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.06208809 |
73 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.98843237 |
74 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.98588120 |
75 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.98022771 |
76 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.97624011 |
77 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.96659281 |
78 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.95893643 |
79 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.92341374 |
80 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.92044116 |
81 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.91636911 |
82 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.89379241 |
83 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.89114152 |
84 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.88969797 |
85 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 0.88370098 |
86 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.86223068 |
87 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.84933615 |
88 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.84086852 |
89 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.83950107 |
90 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.83882359 |
91 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.83633968 |
92 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.80257355 |
93 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.79964576 |
94 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.79905257 |
95 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.79871027 |
96 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.78590418 |
97 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.78020707 |
98 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.77071031 |
99 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.76889038 |
100 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.76710560 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 6.36827016 |
2 | MP0006292_abnormal_olfactory_placode | 3.58797155 |
3 | MP0003186_abnormal_redox_activity | 3.35857347 |
4 | MP0010030_abnormal_orbit_morphology | 3.32604781 |
5 | MP0003806_abnormal_nucleotide_metabolis | 3.18357142 |
6 | MP0008058_abnormal_DNA_repair | 3.06868338 |
7 | MP0003693_abnormal_embryo_hatching | 2.96722303 |
8 | MP0006036_abnormal_mitochondrial_physio | 2.80714907 |
9 | MP0004957_abnormal_blastocyst_morpholog | 2.71869717 |
10 | MP0006035_abnormal_mitochondrial_morpho | 2.37774353 |
11 | MP0003786_premature_aging | 2.35961243 |
12 | MP0003011_delayed_dark_adaptation | 2.32009590 |
13 | MP0002163_abnormal_gland_morphology | 2.27020835 |
14 | MP0000372_irregular_coat_pigmentation | 2.17428429 |
15 | MP0008932_abnormal_embryonic_tissue | 2.02187263 |
16 | MP0003718_maternal_effect | 1.97186720 |
17 | MP0003111_abnormal_nucleus_morphology | 1.90966159 |
18 | MP0002277_abnormal_respiratory_mucosa | 1.89438805 |
19 | MP0005084_abnormal_gallbladder_morpholo | 1.87766334 |
20 | MP0002938_white_spotting | 1.86581765 |
21 | MP0008789_abnormal_olfactory_epithelium | 1.86189844 |
22 | MP0003077_abnormal_cell_cycle | 1.84999021 |
23 | MP0001905_abnormal_dopamine_level | 1.82824621 |
24 | MP0003136_yellow_coat_color | 1.76439494 |
25 | MP0002736_abnormal_nociception_after | 1.74299713 |
26 | MP0010094_abnormal_chromosome_stability | 1.73690006 |
27 | MP0009333_abnormal_splenocyte_physiolog | 1.72719724 |
28 | MP0001529_abnormal_vocalization | 1.64288145 |
29 | MP0008007_abnormal_cellular_replicative | 1.55403901 |
30 | MP0001293_anophthalmia | 1.50785689 |
31 | MP0002837_dystrophic_cardiac_calcinosis | 1.43982873 |
32 | MP0000049_abnormal_middle_ear | 1.41859098 |
33 | MP0003123_paternal_imprinting | 1.41093796 |
34 | MP0006072_abnormal_retinal_apoptosis | 1.40588499 |
35 | MP0002653_abnormal_ependyma_morphology | 1.38984097 |
36 | MP0000358_abnormal_cell_content/ | 1.36697494 |
37 | MP0001919_abnormal_reproductive_system | 1.30918620 |
38 | MP0005389_reproductive_system_phenotype | 1.24441889 |
39 | MP0002234_abnormal_pharynx_morphology | 1.24179193 |
40 | MP0005379_endocrine/exocrine_gland_phen | 1.23831358 |
41 | MP0008995_early_reproductive_senescence | 1.21730372 |
42 | MP0002160_abnormal_reproductive_system | 1.20224770 |
43 | MP0004142_abnormal_muscle_tone | 1.19283268 |
44 | MP0008875_abnormal_xenobiotic_pharmacok | 1.17996030 |
45 | MP0001968_abnormal_touch/_nociception | 1.16897064 |
46 | MP0001764_abnormal_homeostasis | 1.14605306 |
47 | MP0002210_abnormal_sex_determination | 1.14380210 |
48 | MP0001346_abnormal_lacrimal_gland | 1.12296845 |
49 | MP0000750_abnormal_muscle_regeneration | 1.09578771 |
50 | MP0005499_abnormal_olfactory_system | 1.09129987 |
51 | MP0005394_taste/olfaction_phenotype | 1.09129987 |
52 | MP0001986_abnormal_taste_sensitivity | 1.09065483 |
53 | MP0002095_abnormal_skin_pigmentation | 1.07059127 |
54 | MP0005075_abnormal_melanosome_morpholog | 1.04733248 |
55 | MP0005408_hypopigmentation | 1.02077997 |
56 | MP0001485_abnormal_pinna_reflex | 1.01337506 |
57 | MP0002102_abnormal_ear_morphology | 0.95264537 |
58 | MP0001881_abnormal_mammary_gland | 0.95026527 |
59 | MP0003938_abnormal_ear_development | 0.92466327 |
60 | MP0000631_abnormal_neuroendocrine_gland | 0.90431071 |
61 | MP0005332_abnormal_amino_acid | 0.89607899 |
62 | MP0005377_hearing/vestibular/ear_phenot | 0.89217258 |
63 | MP0003878_abnormal_ear_physiology | 0.89217258 |
64 | MP0004019_abnormal_vitamin_homeostasis | 0.87968475 |
65 | MP0008872_abnormal_physiological_respon | 0.87276802 |
66 | MP0001542_abnormal_bone_strength | 0.86635942 |
67 | MP0003315_abnormal_perineum_morphology | 0.85635843 |
68 | MP0005410_abnormal_fertilization | 0.84917165 |
69 | MP0004133_heterotaxia | 0.84508653 |
70 | MP0001853_heart_inflammation | 0.84099877 |
71 | MP0009250_abnormal_appendicular_skeleto | 0.83205964 |
72 | MP0003646_muscle_fatigue | 0.80360189 |
73 | MP0001145_abnormal_male_reproductive | 0.78825071 |
74 | MP0001188_hyperpigmentation | 0.78290074 |
75 | MP0000653_abnormal_sex_gland | 0.78048083 |
76 | MP0001929_abnormal_gametogenesis | 0.77473602 |
77 | MP0000313_abnormal_cell_death | 0.76079791 |
78 | MP0005551_abnormal_eye_electrophysiolog | 0.72060884 |
79 | MP0005646_abnormal_pituitary_gland | 0.72005989 |
80 | MP0005636_abnormal_mineral_homeostasis | 0.71421627 |
81 | MP0005645_abnormal_hypothalamus_physiol | 0.69604998 |
82 | MP0002282_abnormal_trachea_morphology | 0.68867043 |
83 | MP0002254_reproductive_system_inflammat | 0.68545010 |
84 | MP0005423_abnormal_somatic_nervous | 0.68369256 |
85 | MP0000749_muscle_degeneration | 0.67898146 |
86 | MP0005671_abnormal_response_to | 0.66883765 |
87 | MP0005174_abnormal_tail_pigmentation | 0.66467324 |
88 | MP0001119_abnormal_female_reproductive | 0.65723726 |
89 | MP0000026_abnormal_inner_ear | 0.64265244 |
90 | MP0002148_abnormal_hypersensitivity_rea | 0.63328967 |
91 | MP0000350_abnormal_cell_proliferation | 0.62768009 |
92 | MP0005171_absent_coat_pigmentation | 0.60902428 |
93 | MP0004145_abnormal_muscle_electrophysio | 0.60273071 |
94 | MP0002876_abnormal_thyroid_physiology | 0.59686799 |
95 | MP0004885_abnormal_endolymph | 0.59508661 |
96 | MP0005083_abnormal_biliary_tract | 0.57227971 |
97 | MP0005670_abnormal_white_adipose | 0.56517456 |
98 | MP0005253_abnormal_eye_physiology | 0.56063235 |
99 | MP0004742_abnormal_vestibular_system | 0.55288036 |
100 | MP0001944_abnormal_pancreas_morphology | 0.55073901 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 6.61853273 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 6.19626236 |
3 | Mitochondrial inheritance (HP:0001427) | 6.03427121 |
4 | Acute encephalopathy (HP:0006846) | 5.65446990 |
5 | Progressive macrocephaly (HP:0004481) | 5.37564089 |
6 | Increased CSF lactate (HP:0002490) | 5.32078901 |
7 | Increased hepatocellular lipid droplets (HP:0006565) | 5.29990727 |
8 | Hepatocellular necrosis (HP:0001404) | 5.20020347 |
9 | Abnormality of cells of the erythroid lineage (HP:0012130) | 5.03796972 |
10 | Abnormal number of erythroid precursors (HP:0012131) | 4.92518814 |
11 | Reticulocytopenia (HP:0001896) | 4.89938558 |
12 | Renal Fanconi syndrome (HP:0001994) | 4.72472573 |
13 | Lipid accumulation in hepatocytes (HP:0006561) | 4.71497838 |
14 | Hepatic necrosis (HP:0002605) | 4.63744494 |
15 | Increased intramyocellular lipid droplets (HP:0012240) | 4.42930548 |
16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.30499199 |
17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.30499199 |
18 | Cerebral edema (HP:0002181) | 4.15193669 |
19 | Macrocytic anemia (HP:0001972) | 4.04277782 |
20 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 4.01640442 |
21 | Increased muscle lipid content (HP:0009058) | 3.71517226 |
22 | Exercise intolerance (HP:0003546) | 3.54121479 |
23 | Exertional dyspnea (HP:0002875) | 3.51984165 |
24 | Lactic acidosis (HP:0003128) | 3.48909228 |
25 | 3-Methylglutaconic aciduria (HP:0003535) | 3.46313301 |
26 | Increased serum lactate (HP:0002151) | 3.45716512 |
27 | Respiratory failure (HP:0002878) | 3.36067174 |
28 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.26904118 |
29 | Respiratory difficulties (HP:0002880) | 3.13084023 |
30 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.07512235 |
31 | Optic disc pallor (HP:0000543) | 2.99184690 |
32 | Aplastic anemia (HP:0001915) | 2.87190171 |
33 | Type I transferrin isoform profile (HP:0003642) | 2.85777022 |
34 | Leukodystrophy (HP:0002415) | 2.85215182 |
35 | Pallor (HP:0000980) | 2.79318070 |
36 | Abnormality of renal resorption (HP:0011038) | 2.69846598 |
37 | Absent thumb (HP:0009777) | 2.59426240 |
38 | Lethargy (HP:0001254) | 2.53196226 |
39 | Pancytopenia (HP:0001876) | 2.39620922 |
40 | Oral leukoplakia (HP:0002745) | 2.38770217 |
41 | Testicular atrophy (HP:0000029) | 2.36713167 |
42 | Methylmalonic aciduria (HP:0012120) | 2.29821035 |
43 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.24150993 |
44 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.24150993 |
45 | Abnormal protein glycosylation (HP:0012346) | 2.24150993 |
46 | Abnormal glycosylation (HP:0012345) | 2.24150993 |
47 | Microvesicular hepatic steatosis (HP:0001414) | 2.18031735 |
48 | Glycosuria (HP:0003076) | 2.17965108 |
49 | Abnormality of urine glucose concentration (HP:0011016) | 2.17965108 |
50 | Hyperphosphaturia (HP:0003109) | 2.17807751 |
51 | CNS demyelination (HP:0007305) | 2.16976056 |
52 | Emotional lability (HP:0000712) | 2.16577906 |
53 | X-linked dominant inheritance (HP:0001423) | 2.14679300 |
54 | Rough bone trabeculation (HP:0100670) | 2.12735089 |
55 | Cerebral hypomyelination (HP:0006808) | 2.10671443 |
56 | Congenital, generalized hypertrichosis (HP:0004540) | 2.10459369 |
57 | Increased serum pyruvate (HP:0003542) | 2.06877570 |
58 | Cleft eyelid (HP:0000625) | 2.06318912 |
59 | Abnormality of midbrain morphology (HP:0002418) | 2.05133922 |
60 | Molar tooth sign on MRI (HP:0002419) | 2.05133922 |
61 | Sparse eyelashes (HP:0000653) | 2.01251736 |
62 | Abnormality of placental membranes (HP:0011409) | 2.00417502 |
63 | Amniotic constriction ring (HP:0009775) | 2.00417502 |
64 | Muscle fiber atrophy (HP:0100295) | 1.99678148 |
65 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.98420137 |
66 | Generalized aminoaciduria (HP:0002909) | 1.97569555 |
67 | Methylmalonic acidemia (HP:0002912) | 1.96413016 |
68 | Microretrognathia (HP:0000308) | 1.95905850 |
69 | Reduced antithrombin III activity (HP:0001976) | 1.95607168 |
70 | Colon cancer (HP:0003003) | 1.88228322 |
71 | Degeneration of anterior horn cells (HP:0002398) | 1.87875540 |
72 | Abnormality of the anterior horn cell (HP:0006802) | 1.87875540 |
73 | Type 2 muscle fiber atrophy (HP:0003554) | 1.86176008 |
74 | Abnormality of glycolysis (HP:0004366) | 1.83539917 |
75 | Blindness (HP:0000618) | 1.83468218 |
76 | Dicarboxylic aciduria (HP:0003215) | 1.80857796 |
77 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.80857796 |
78 | Hypoplasia of the pons (HP:0012110) | 1.80485661 |
79 | Sclerocornea (HP:0000647) | 1.80302332 |
80 | Rib fusion (HP:0000902) | 1.79844836 |
81 | Pancreatic cysts (HP:0001737) | 1.76964249 |
82 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.76435982 |
83 | Abnormality of the pons (HP:0007361) | 1.74898634 |
84 | Pancreatic fibrosis (HP:0100732) | 1.70938988 |
85 | Horseshoe kidney (HP:0000085) | 1.67099546 |
86 | Patent foramen ovale (HP:0001655) | 1.65415156 |
87 | Myokymia (HP:0002411) | 1.64167632 |
88 | Abnormal urine phosphate concentration (HP:0012599) | 1.62836662 |
89 | Abnormal trabecular bone morphology (HP:0100671) | 1.62420544 |
90 | Multiple enchondromatosis (HP:0005701) | 1.60371351 |
91 | Progressive microcephaly (HP:0000253) | 1.58974283 |
92 | Renal tubular dysfunction (HP:0000124) | 1.58498976 |
93 | Poor suck (HP:0002033) | 1.57806272 |
94 | Cellular immunodeficiency (HP:0005374) | 1.56739834 |
95 | Opisthotonus (HP:0002179) | 1.55267046 |
96 | True hermaphroditism (HP:0010459) | 1.53937145 |
97 | Abnormality of magnesium homeostasis (HP:0004921) | 1.52266934 |
98 | Vomiting (HP:0002013) | 1.49232943 |
99 | Death in infancy (HP:0001522) | 1.48358458 |
100 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 1.48037629 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 6.50826711 |
2 | NME2 | 4.39380727 |
3 | BUB1 | 4.26925305 |
4 | STK16 | 3.97680893 |
5 | VRK1 | 2.65157135 |
6 | NME1 | 2.52739904 |
7 | BCKDK | 2.52561125 |
8 | TESK2 | 2.27894066 |
9 | CDC7 | 2.17177949 |
10 | ZAK | 2.17124263 |
11 | TLK1 | 2.07783723 |
12 | NUAK1 | 1.91751478 |
13 | SRPK1 | 1.86100493 |
14 | TESK1 | 1.85696737 |
15 | KDR | 1.81470343 |
16 | PBK | 1.75493583 |
17 | EIF2AK1 | 1.74745603 |
18 | LIMK1 | 1.73338951 |
19 | MAP3K12 | 1.54447534 |
20 | NEK1 | 1.52025883 |
21 | MST4 | 1.50949829 |
22 | PIM2 | 1.49396557 |
23 | DYRK2 | 1.41031238 |
24 | ARAF | 1.38834086 |
25 | ABL2 | 1.37883729 |
26 | PDK2 | 1.36704446 |
27 | LRRK2 | 1.36701681 |
28 | ILK | 1.27120861 |
29 | AURKA | 1.26845168 |
30 | PLK3 | 1.25762317 |
31 | TAF1 | 1.21271181 |
32 | BRSK1 | 1.18032632 |
33 | DAPK3 | 1.08287158 |
34 | ADRBK2 | 1.02556522 |
35 | AURKB | 1.01572442 |
36 | MYLK | 0.98194287 |
37 | BRAF | 0.96706672 |
38 | TRIM28 | 0.96274155 |
39 | MUSK | 0.95726194 |
40 | CDK8 | 0.95611578 |
41 | PLK1 | 0.94225823 |
42 | TSSK6 | 0.89179113 |
43 | PRKCI | 0.87026029 |
44 | MAP3K11 | 0.85474006 |
45 | TXK | 0.85125220 |
46 | EIF2AK3 | 0.84179187 |
47 | RPS6KA5 | 0.83608167 |
48 | PASK | 0.82763925 |
49 | CSNK1G3 | 0.81835479 |
50 | STK4 | 0.80908438 |
51 | DAPK1 | 0.78392259 |
52 | GRK1 | 0.78208398 |
53 | IRAK3 | 0.77386996 |
54 | CHEK2 | 0.76800441 |
55 | CSNK1G1 | 0.76501519 |
56 | EPHB2 | 0.74237356 |
57 | CSNK2A2 | 0.72180058 |
58 | CDK19 | 0.71847047 |
59 | PAK4 | 0.71355570 |
60 | CSNK2A1 | 0.70462590 |
61 | PAK1 | 0.70347131 |
62 | MAPK15 | 0.66716748 |
63 | TTK | 0.62952054 |
64 | MAPKAPK3 | 0.62650663 |
65 | BMPR1B | 0.60452940 |
66 | INSRR | 0.58590749 |
67 | ATR | 0.56242603 |
68 | DYRK3 | 0.56158588 |
69 | PLK4 | 0.56057182 |
70 | IKBKB | 0.55378430 |
71 | WEE1 | 0.53260790 |
72 | EPHA2 | 0.51317505 |
73 | CDK7 | 0.50066561 |
74 | WNK3 | 0.48741913 |
75 | MAP2K7 | 0.48468666 |
76 | RPS6KB2 | 0.47203999 |
77 | ADRBK1 | 0.46704944 |
78 | GRK5 | 0.46423914 |
79 | CSNK1G2 | 0.45707555 |
80 | CCNB1 | 0.45450297 |
81 | SMG1 | 0.44549405 |
82 | WNK4 | 0.43379947 |
83 | TAOK2 | 0.41415002 |
84 | CSNK1A1L | 0.39843114 |
85 | BRSK2 | 0.38925756 |
86 | MAP2K2 | 0.37624086 |
87 | AKT2 | 0.34413132 |
88 | MAP4K2 | 0.33171344 |
89 | MAP3K8 | 0.31218824 |
90 | PINK1 | 0.30330038 |
91 | CAMK2G | 0.29796393 |
92 | EIF2AK2 | 0.29043791 |
93 | GRK7 | 0.28916936 |
94 | NEK2 | 0.28816683 |
95 | CHEK1 | 0.28780995 |
96 | MARK3 | 0.27021509 |
97 | PRKCG | 0.26210234 |
98 | CSNK1A1 | 0.24155295 |
99 | PIM1 | 0.24137882 |
100 | CSNK1E | 0.24112012 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.80783303 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.93715206 |
3 | Proteasome_Homo sapiens_hsa03050 | 4.75154811 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 4.21542916 |
5 | RNA polymerase_Homo sapiens_hsa03020 | 3.43610786 |
6 | Huntingtons disease_Homo sapiens_hsa05016 | 3.09417132 |
7 | Alzheimers disease_Homo sapiens_hsa05010 | 2.84142447 |
8 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.69602443 |
9 | Protein export_Homo sapiens_hsa03060 | 2.60489970 |
10 | DNA replication_Homo sapiens_hsa03030 | 2.49070982 |
11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.35210274 |
12 | Mismatch repair_Homo sapiens_hsa03430 | 2.19158301 |
13 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.00789897 |
14 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.00199054 |
15 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.93030781 |
16 | Homologous recombination_Homo sapiens_hsa03440 | 1.91186205 |
17 | Spliceosome_Homo sapiens_hsa03040 | 1.86921433 |
18 | Base excision repair_Homo sapiens_hsa03410 | 1.81425803 |
19 | Sulfur relay system_Homo sapiens_hsa04122 | 1.76338593 |
20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.60278965 |
21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.45918552 |
22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.45813054 |
23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.33718029 |
24 | RNA transport_Homo sapiens_hsa03013 | 1.31899759 |
25 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.29603195 |
26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27085221 |
27 | Purine metabolism_Homo sapiens_hsa00230 | 1.25459028 |
28 | RNA degradation_Homo sapiens_hsa03018 | 1.23591772 |
29 | Basal transcription factors_Homo sapiens_hsa03022 | 1.17130385 |
30 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.17088454 |
31 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.16872675 |
32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.12697445 |
33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.09459889 |
34 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.99189529 |
35 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.98100928 |
36 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.95019593 |
37 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.93630641 |
38 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.91900266 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85639231 |
40 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.85140445 |
41 | Metabolic pathways_Homo sapiens_hsa01100 | 0.82315595 |
42 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.76246023 |
43 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.70794409 |
44 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.66038151 |
45 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.65568391 |
46 | Peroxisome_Homo sapiens_hsa04146 | 0.59179696 |
47 | Carbon metabolism_Homo sapiens_hsa01200 | 0.57780648 |
48 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.57541718 |
49 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.56602170 |
50 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.56030271 |
51 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.54691864 |
52 | Cell cycle_Homo sapiens_hsa04110 | 0.53506779 |
53 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.52773894 |
54 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.51120113 |
55 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.46403378 |
56 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.45858832 |
57 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.43431657 |
58 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.42793407 |
59 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.40654733 |
60 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.38699497 |
61 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37676784 |
62 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.36338500 |
63 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.35987837 |
64 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.35867880 |
65 | Phototransduction_Homo sapiens_hsa04744 | 0.35836518 |
66 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34580501 |
67 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.33983787 |
68 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.33594363 |
69 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.31074020 |
70 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.29834062 |
71 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.29827878 |
72 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.28605115 |
73 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.27984828 |
74 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.27066717 |
75 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26765544 |
76 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.26414676 |
77 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.26293095 |
78 | Galactose metabolism_Homo sapiens_hsa00052 | 0.25939323 |
79 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.24376936 |
80 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.24306240 |
81 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.24147443 |
82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.23875310 |
83 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.20841206 |
84 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.20410204 |
85 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.19033424 |
86 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.17874149 |
87 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.16775805 |
88 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.16228461 |
89 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.15339878 |
90 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.13954833 |
91 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.13578311 |
92 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.13039446 |
93 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.10024143 |
94 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.09110730 |
95 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.09015283 |
96 | Alcoholism_Homo sapiens_hsa05034 | 0.08545403 |
97 | Mineral absorption_Homo sapiens_hsa04978 | 0.07503802 |
98 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.07206005 |
99 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.06762182 |
100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.05228828 |