C19orf57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.90205563
2DNA strand elongation (GO:0022616)4.73886256
3DNA unwinding involved in DNA replication (GO:0006268)4.65435840
4telomere maintenance via semi-conservative replication (GO:0032201)4.65190569
5DNA replication initiation (GO:0006270)4.36957713
6translesion synthesis (GO:0019985)4.35980144
7DNA replication checkpoint (GO:0000076)4.26794710
8mitotic sister chromatid cohesion (GO:0007064)3.99261664
9postreplication repair (GO:0006301)3.94903608
10telomere maintenance via recombination (GO:0000722)3.92958945
11mitotic chromosome condensation (GO:0007076)3.79273646
12nucleotide-excision repair, DNA gap filling (GO:0006297)3.71758396
13meiotic chromosome segregation (GO:0045132)3.68746932
14DNA double-strand break processing (GO:0000729)3.66000677
15regulation of double-strand break repair via homologous recombination (GO:0010569)3.63018139
16mitotic recombination (GO:0006312)3.61238796
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.56334635
18DNA synthesis involved in DNA repair (GO:0000731)3.53520484
19regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48750267
20DNA topological change (GO:0006265)3.42776125
21sister chromatid cohesion (GO:0007062)3.37096924
22histone H2A acetylation (GO:0043968)3.29699662
23chromosome organization involved in meiosis (GO:0070192)3.21308738
24protein localization to chromosome, centromeric region (GO:0071459)3.15647883
25presynaptic membrane assembly (GO:0097105)3.13442442
26regulation of sister chromatid cohesion (GO:0007063)3.13251936
27protein localization to kinetochore (GO:0034501)3.11861248
28postsynaptic membrane organization (GO:0001941)3.10169837
29synaptonemal complex assembly (GO:0007130)3.09454543
30negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.09127070
31kinetochore organization (GO:0051383)3.07518161
32microtubule depolymerization (GO:0007019)3.05564422
33telomere maintenance via telomere lengthening (GO:0010833)3.03953460
34synapsis (GO:0007129)3.03438977
35protein localization to chromosome (GO:0034502)3.01578637
36regulation of DNA endoreduplication (GO:0032875)3.01388646
37piRNA metabolic process (GO:0034587)3.00004739
38histone arginine methylation (GO:0034969)2.93100724
39protein K6-linked ubiquitination (GO:0085020)2.91250121
40DNA replication-dependent nucleosome organization (GO:0034723)2.88226274
41DNA replication-dependent nucleosome assembly (GO:0006335)2.88226274
42DNA biosynthetic process (GO:0071897)2.87794636
43CENP-A containing nucleosome assembly (GO:0034080)2.87791240
44chromatin remodeling at centromere (GO:0031055)2.87563725
45mitotic sister chromatid segregation (GO:0000070)2.86757009
46protein insertion into membrane (GO:0051205)2.86186117
47base-excision repair (GO:0006284)2.85901228
48neuron cell-cell adhesion (GO:0007158)2.84278084
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.79230962
50negative regulation of mRNA processing (GO:0050686)2.78366583
51dosage compensation (GO:0007549)2.74793160
52protein-DNA complex disassembly (GO:0032986)2.74313319
53nucleosome disassembly (GO:0006337)2.74313319
54establishment of integrated proviral latency (GO:0075713)2.73978645
55synaptonemal complex organization (GO:0070193)2.73567384
56establishment of mitochondrion localization (GO:0051654)2.72605353
57DNA replication (GO:0006260)2.72451732
58pyrimidine nucleobase catabolic process (GO:0006208)2.72367350
59DNA methylation involved in gamete generation (GO:0043046)2.72286843
60cell migration in hindbrain (GO:0021535)2.72036953
61regulation of centriole replication (GO:0046599)2.71705557
62positive regulation of DNA-dependent DNA replication (GO:2000105)2.68961554
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66819611
64nonmotile primary cilium assembly (GO:0035058)2.66405846
65DNA damage response, detection of DNA damage (GO:0042769)2.65768170
66mechanosensory behavior (GO:0007638)2.62047902
67peptidyl-arginine omega-N-methylation (GO:0035247)2.61387599
68auditory behavior (GO:0031223)2.61368518
69neurofilament cytoskeleton organization (GO:0060052)2.60763945
70resolution of meiotic recombination intermediates (GO:0000712)2.59196363
71ATP-dependent chromatin remodeling (GO:0043044)2.58660409
72DNA replication-independent nucleosome assembly (GO:0006336)2.58439347
73DNA replication-independent nucleosome organization (GO:0034724)2.58439347
74kinetochore assembly (GO:0051382)2.57727450
75sister chromatid segregation (GO:0000819)2.57224701
76spliceosomal tri-snRNP complex assembly (GO:0000244)2.56091192
77mRNA splice site selection (GO:0006376)2.53328475
78mitochondrial DNA metabolic process (GO:0032042)2.53003225
79L-serine metabolic process (GO:0006563)2.52108205
80regulation of DNA-dependent DNA replication (GO:0090329)2.51163929
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.49854810
82regulation of meiosis I (GO:0060631)2.48976893
83regulation of centrosome cycle (GO:0046605)2.48811836
84gamma-aminobutyric acid transport (GO:0015812)2.48501594
85fatty acid elongation (GO:0030497)2.48286427
86negative regulation of RNA splicing (GO:0033119)2.47197860
87mitochondrial DNA replication (GO:0006264)2.46862891
88regulation of mitochondrial translation (GO:0070129)2.43858362
89mismatch repair (GO:0006298)2.42465071
90positive regulation of growth hormone secretion (GO:0060124)2.41510971
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.41436323
92transcription-coupled nucleotide-excision repair (GO:0006283)2.40955587
93spliceosomal snRNP assembly (GO:0000387)2.40910426
94meiotic nuclear division (GO:0007126)2.40550116
95DNA ligation (GO:0006266)2.39143554
96presynaptic membrane organization (GO:0097090)2.39055595
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.38625442
98histone exchange (GO:0043486)2.38220387
99chromosome segregation (GO:0007059)2.37026154
100chromatin assembly or disassembly (GO:0006333)2.34209645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.76435990
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.48187083
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11569471
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.00429358
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84133496
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.76106706
7EZH2_22144423_ChIP-Seq_EOC_Human2.61947714
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.61711596
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57622452
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36914496
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28667671
12THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25845227
13* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21955589
14XRN2_22483619_ChIP-Seq_HELA_Human2.21514975
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.16626617
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.16578565
17CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.13489277
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13017501
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11883355
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.11526254
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.09087216
22TTF2_22483619_ChIP-Seq_HELA_Human2.02382957
23E2F7_22180533_ChIP-Seq_HELA_Human10.3251756
24* GABP_19822575_ChIP-Seq_HepG2_Human1.99447852
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99381101
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95404664
27DCP1A_22483619_ChIP-Seq_HELA_Human1.93326263
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89069249
29MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85898410
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.85603402
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81446479
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79172711
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.76506055
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71908894
35KDM5A_27292631_Chip-Seq_BREAST_Human1.63847158
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63574886
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63380484
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.60200996
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.59957122
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57454530
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57100149
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51901962
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51002044
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45931625
45AR_21909140_ChIP-Seq_LNCAP_Human1.45353574
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45312316
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45206327
48MYC_18940864_ChIP-ChIP_HL60_Human1.43433738
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41093905
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40440435
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40195833
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37751652
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36128431
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30511827
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.25204959
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24576697
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.23606059
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23081336
59CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22505202
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20678335
61VDR_23849224_ChIP-Seq_CD4+_Human1.17985849
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14646340
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12246226
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.11312994
65FOXP3_21729870_ChIP-Seq_TREG_Human1.08576376
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08308211
67HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08001501
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.07855541
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07501521
70CIITA_25753668_ChIP-Seq_RAJI_Human1.02373992
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00129356
72NANOG_21062744_ChIP-ChIP_HESCs_Human0.97702473
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97578700
74PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97102917
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.96472892
76KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93636405
77RNF2_27304074_Chip-Seq_NSC_Mouse0.93132906
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92155582
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91452893
80PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91285872
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91111423
82SOX2_16153702_ChIP-ChIP_HESCs_Human0.90590025
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89273566
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87591281
85EZH2_27304074_Chip-Seq_ESCs_Mouse0.85734955
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85274010
87ELK1_19687146_ChIP-ChIP_HELA_Human0.84605573
88* FOXP1_21924763_ChIP-Seq_HESCs_Human0.83811914
89P68_20966046_ChIP-Seq_HELA_Human0.83602615
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82271697
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82175675
92CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79267403
93REST_18959480_ChIP-ChIP_MESCs_Mouse0.78215327
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75045927
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74364109
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73628026
97SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72434723
98MYC_22102868_ChIP-Seq_BL_Human0.71873381
99CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71723122
100POU5F1_16153702_ChIP-ChIP_HESCs_Human0.71403894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.70656095
2MP0001529_abnormal_vocalization2.88400235
3MP0003111_abnormal_nucleus_morphology2.85944882
4MP0008058_abnormal_DNA_repair2.71681471
5MP0001188_hyperpigmentation2.66562713
6MP0002822_catalepsy2.60239232
7MP0008057_abnormal_DNA_replication2.46968537
8MP0003693_abnormal_embryo_hatching2.41504050
9MP0003077_abnormal_cell_cycle2.17400260
10MP0003880_abnormal_central_pattern2.00574938
11MP0008932_abnormal_embryonic_tissue1.93963629
12MP0005394_taste/olfaction_phenotype1.83780222
13MP0005499_abnormal_olfactory_system1.83780222
14MP0002210_abnormal_sex_determination1.81529144
15MP0008789_abnormal_olfactory_epithelium1.78585034
16MP0003283_abnormal_digestive_organ1.68788349
17MP0006292_abnormal_olfactory_placode1.68402428
18MP0000537_abnormal_urethra_morphology1.67121323
19MP0000566_synostosis1.61562674
20MP0008995_early_reproductive_senescence1.60442809
21MP0005646_abnormal_pituitary_gland1.59385882
22MP0004957_abnormal_blastocyst_morpholog1.57591827
23MP0002234_abnormal_pharynx_morphology1.51014398
24MP0008877_abnormal_DNA_methylation1.50881204
25MP0001346_abnormal_lacrimal_gland1.49172136
26MP0000631_abnormal_neuroendocrine_gland1.48962940
27MP0003119_abnormal_digestive_system1.48009564
28MP0004859_abnormal_synaptic_plasticity1.47674269
29MP0000049_abnormal_middle_ear1.44041926
30MP0001929_abnormal_gametogenesis1.41243037
31MP0002735_abnormal_chemical_nociception1.39997749
32MP0002249_abnormal_larynx_morphology1.39428769
33MP0003718_maternal_effect1.38526139
34MP0005423_abnormal_somatic_nervous1.33971188
35MP0000778_abnormal_nervous_system1.32895977
36MP0001145_abnormal_male_reproductive1.32757364
37MP0003861_abnormal_nervous_system1.31063464
38MP0004147_increased_porphyrin_level1.30753261
39MP0006276_abnormal_autonomic_nervous1.29913001
40MP0001984_abnormal_olfaction1.28697682
41MP0010307_abnormal_tumor_latency1.23874751
42MP0001730_embryonic_growth_arrest1.23676427
43MP0010030_abnormal_orbit_morphology1.23472957
44MP0000653_abnormal_sex_gland1.23142356
45MP0008260_abnormal_autophagy1.20477564
46MP0003635_abnormal_synaptic_transmissio1.19751860
47MP0008007_abnormal_cellular_replicative1.13607630
48MP0003698_abnormal_male_reproductive1.13046196
49MP0006035_abnormal_mitochondrial_morpho1.11779620
50MP0003385_abnormal_body_wall1.10905409
51MP0003937_abnormal_limbs/digits/tail_de1.08203388
52MP0000350_abnormal_cell_proliferation1.08120402
53MP0003890_abnormal_embryonic-extraembry1.07166823
54MP0001486_abnormal_startle_reflex1.05525500
55MP0002736_abnormal_nociception_after1.04542249
56MP0002751_abnormal_autonomic_nervous1.04431941
57MP0004197_abnormal_fetal_growth/weight/1.03827029
58MP0004811_abnormal_neuron_physiology1.01500220
59MP0000678_abnormal_parathyroid_gland1.01307117
60MP0002085_abnormal_embryonic_tissue1.00938542
61MP0000462_abnormal_digestive_system1.00650835
62MP0000955_abnormal_spinal_cord0.99270148
63MP0002557_abnormal_social/conspecific_i0.99099441
64MP0003121_genomic_imprinting0.98236026
65MP0002111_abnormal_tail_morphology0.98026566
66MP0002152_abnormal_brain_morphology0.97574303
67MP0002909_abnormal_adrenal_gland0.97262378
68MP0003786_premature_aging0.97026815
69MP0000751_myopathy0.96301079
70MP0003136_yellow_coat_color0.95630756
71MP0002882_abnormal_neuron_morphology0.94909699
72MP0002063_abnormal_learning/memory/cond0.93771748
73MP0003938_abnormal_ear_development0.93745967
74MP0002161_abnormal_fertility/fecundity0.93657339
75MP0003755_abnormal_palate_morphology0.92529551
76MP0002653_abnormal_ependyma_morphology0.91865497
77MP0002572_abnormal_emotion/affect_behav0.91851034
78MP0009046_muscle_twitch0.91088262
79MP0005380_embryogenesis_phenotype0.90876522
80MP0001672_abnormal_embryogenesis/_devel0.90876522
81MP0002160_abnormal_reproductive_system0.89392006
82MP0000516_abnormal_urinary_system0.89256704
83MP0005367_renal/urinary_system_phenotyp0.89256704
84MP0009672_abnormal_birth_weight0.89202494
85MP0002084_abnormal_developmental_patter0.88937928
86MP0001697_abnormal_embryo_size0.88345484
87MP0002272_abnormal_nervous_system0.86110744
88MP0002697_abnormal_eye_size0.86102237
89MP0003315_abnormal_perineum_morphology0.85324240
90MP0002080_prenatal_lethality0.84964249
91MP0003935_abnormal_craniofacial_develop0.82841550
92MP0001968_abnormal_touch/_nociception0.82597503
93MP0000534_abnormal_ureter_morphology0.82373081
94MP0002734_abnormal_mechanical_nocicepti0.82198982
95MP0000358_abnormal_cell_content/0.82063207
96MP0002098_abnormal_vibrissa_morphology0.81655500
97MP0004270_analgesia0.81467193
98MP0000026_abnormal_inner_ear0.81161016
99MP0002184_abnormal_innervation0.80577517
100MP0003699_abnormal_female_reproductive0.80404251

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.97346573
2Chromsome breakage (HP:0040012)3.55730363
3Volvulus (HP:0002580)3.22456230
4Cortical dysplasia (HP:0002539)3.17110593
5Retinal dysplasia (HP:0007973)3.12067637
6Birth length less than 3rd percentile (HP:0003561)2.99785063
7Aplasia/Hypoplasia of the uvula (HP:0010293)2.98319176
8Meckel diverticulum (HP:0002245)2.87718473
9Abnormality of the ileum (HP:0001549)2.83376812
10Abnormality of the preputium (HP:0100587)2.72786777
11Increased nuchal translucency (HP:0010880)2.69785257
12Patellar aplasia (HP:0006443)2.50330465
13Facial hemangioma (HP:0000329)2.49513958
14Shoulder girdle muscle weakness (HP:0003547)2.49363416
15Morphological abnormality of the inner ear (HP:0011390)2.46118660
16Ectopic kidney (HP:0000086)2.39470324
17Abnormality of chromosome stability (HP:0003220)2.38620529
18Oligodactyly (hands) (HP:0001180)2.38262472
19Abnormality of the labia minora (HP:0012880)2.38107018
20Abnormality of the carotid arteries (HP:0005344)2.35054299
21Aplasia/Hypoplasia of the patella (HP:0006498)2.29008472
22Gait imbalance (HP:0002141)2.24391727
23Oligodactyly (HP:0012165)2.20829455
24Cholecystitis (HP:0001082)2.16307895
25Abnormal gallbladder physiology (HP:0012438)2.16307895
26Duodenal stenosis (HP:0100867)2.15876699
27Small intestinal stenosis (HP:0012848)2.15876699
28Abnormality of the lower motor neuron (HP:0002366)2.14285210
29Abnormality of cochlea (HP:0000375)2.04571648
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.04318439
31Congenital primary aphakia (HP:0007707)2.03866135
32Obsessive-compulsive behavior (HP:0000722)2.02862216
33Absent forearm bone (HP:0003953)2.01113009
34Aplasia involving forearm bones (HP:0009822)2.01113009
35Delayed myelination (HP:0012448)2.00472766
36Heterotopia (HP:0002282)1.98724836
37Absent radius (HP:0003974)1.98239766
38Duplicated collecting system (HP:0000081)1.97723903
39Nephrogenic diabetes insipidus (HP:0009806)1.97654427
40Ulnar claw (HP:0001178)1.96343185
41Triphalangeal thumb (HP:0001199)1.95154908
42Abnormality of the duodenum (HP:0002246)1.93271535
43Impulsivity (HP:0100710)1.92936881
44Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92076101
45Hypoplasia of the brainstem (HP:0002365)1.92076101
46Broad alveolar ridges (HP:0000187)1.91277601
47Microvesicular hepatic steatosis (HP:0001414)1.88927558
48Gonadotropin excess (HP:0000837)1.88190962
49Lissencephaly (HP:0001339)1.84103615
50Clubbing of toes (HP:0100760)1.84093740
51Microglossia (HP:0000171)1.82884609
52Medial flaring of the eyebrow (HP:0010747)1.81237335
53Urethral obstruction (HP:0000796)1.79433949
54Progressive microcephaly (HP:0000253)1.78230304
55Medulloblastoma (HP:0002885)1.78015109
56Pachygyria (HP:0001302)1.76863047
57Abnormal hair whorl (HP:0010721)1.76681229
58Sloping forehead (HP:0000340)1.75541573
59Bowel incontinence (HP:0002607)1.74409968
60Capillary hemangiomas (HP:0005306)1.74343411
61Hammertoe (HP:0001765)1.72684440
62High anterior hairline (HP:0009890)1.71951089
63Short thumb (HP:0009778)1.71527750
64Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71451685
65Homocystinuria (HP:0002156)1.70480989
66Abnormality of homocysteine metabolism (HP:0010919)1.70480989
67Gastroesophageal reflux (HP:0002020)1.69570053
68Abnormality of the renal collecting system (HP:0004742)1.69243381
69Proximal placement of thumb (HP:0009623)1.68790848
70Choanal atresia (HP:0000453)1.68463568
71Methylmalonic acidemia (HP:0002912)1.68096079
7211 pairs of ribs (HP:0000878)1.67466756
73Astigmatism (HP:0000483)1.66428376
74Hypsarrhythmia (HP:0002521)1.66194806
75Postnatal microcephaly (HP:0005484)1.66119548
76Split foot (HP:0001839)1.65531946
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.65017435
78Abnormality of the parathyroid morphology (HP:0011766)1.64860644
79Urinary urgency (HP:0000012)1.64859743
80Degeneration of anterior horn cells (HP:0002398)1.64022613
81Abnormality of the anterior horn cell (HP:0006802)1.64022613
82Arteriovenous malformation (HP:0100026)1.63797973
83Type I transferrin isoform profile (HP:0003642)1.63623095
84Acute lymphatic leukemia (HP:0006721)1.63255860
85Abnormal large intestine physiology (HP:0012700)1.62508301
86Genital tract atresia (HP:0001827)1.62506492
87Abnormal lung lobation (HP:0002101)1.61304696
88Duplication of thumb phalanx (HP:0009942)1.59788820
89Myelodysplasia (HP:0002863)1.59441281
90Back pain (HP:0003418)1.58229964
91Peripheral hypomyelination (HP:0007182)1.58063129
92Horseshoe kidney (HP:0000085)1.57478566
93Septate vagina (HP:0001153)1.53694469
94Breast hypoplasia (HP:0003187)1.53473786
95EEG with generalized epileptiform discharges (HP:0011198)1.51644667
96Aganglionic megacolon (HP:0002251)1.51446623
97Cafe-au-lait spot (HP:0000957)1.51393691
98Abnormality of lateral ventricle (HP:0030047)1.51265722
99Limb dystonia (HP:0002451)1.50975845
100Drooling (HP:0002307)1.50171928

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.03951523
2PNCK3.16373613
3CDK82.56481925
4BMPR1B2.35816791
5MARK12.30916572
6WEE12.27862193
7BCKDK2.14579977
8SRPK12.09752687
9PRKD32.07896909
10ICK2.05724710
11TSSK61.93668797
12CASK1.93152441
13TTK1.82129263
14CHEK21.81856456
15MAP2K71.78013670
16ATR1.72104048
17VRK21.69595494
18MAPK131.66896223
19CDK121.63771193
20SIK21.62484671
21NME11.57402061
22PLK41.53613746
23CDK71.51710668
24AURKA1.47841587
25DYRK21.46995806
26CSNK1G31.43237790
27BUB11.43193838
28MAP4K21.39971123
29MAP3K41.39168250
30PLK11.37332418
31PKN21.36100280
32CSNK1A1L1.31874566
33TRIM281.23689069
34BCR1.22577966
35CHEK11.22244603
36PIM21.18277600
37PASK1.15601661
38PBK1.15282887
39CSNK1G21.15203584
40NTRK21.12194104
41NEK21.12045830
42IRAK31.10586195
43ERBB31.09403799
44BRSK11.08743082
45ATM1.08715710
46EEF2K1.05995872
47UHMK11.05030483
48CDK11A1.04101932
49TRIB31.00691477
50RPS6KA40.99830189
51CDK140.98744571
52AURKB0.98655575
53CDK150.94763062
54CSNK1G10.93960077
55CDK20.93620501
56CDK180.91965618
57CDK190.87770238
58BRSK20.87143605
59MINK10.86189183
60CDK40.86064593
61VRK10.85597478
62NEK10.83179272
63CDK10.82933332
64LMTK20.82307136
65TESK20.80802642
66CLK10.78326475
67BRD40.77102551
68CCNB10.75523121
69MAPK150.73981178
70BRAF0.70390521
71MAP2K40.70008125
72MAP3K100.66125787
73SMG10.62988958
74CAMK1G0.61179436
75INSRR0.59466962
76TESK10.59310551
77CDK30.58826101
78DYRK1A0.58693035
79CSNK1E0.58237253
80WNK30.56232602
81ARAF0.55871242
82RPS6KA50.53951206
83PRKDC0.53542431
84GSK3B0.50224585
85PRKCZ0.48711866
86CSNK2A10.48550184
87MAPK100.47537272
88CSNK2A20.47446537
89MET0.47131615
90PRKCI0.46798769
91EPHA40.45710363
92KSR10.45429144
93EIF2AK20.45336807
94PLK30.44218036
95PRKCG0.44072445
96DYRK30.43824548
97MAPK90.43362876
98MAP3K50.43059626
99EIF2AK10.42990982
100SIK10.42932216

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.16689647
2Mismatch repair_Homo sapiens_hsa034303.56401835
3Base excision repair_Homo sapiens_hsa034103.31076042
4Fanconi anemia pathway_Homo sapiens_hsa034602.87473374
5Homologous recombination_Homo sapiens_hsa034402.68067768
6Cell cycle_Homo sapiens_hsa041102.49503075
7Spliceosome_Homo sapiens_hsa030402.27809409
8Sulfur relay system_Homo sapiens_hsa041222.19698090
9Nucleotide excision repair_Homo sapiens_hsa034202.16517560
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16375435
11Folate biosynthesis_Homo sapiens_hsa007902.09705646
12Basal transcription factors_Homo sapiens_hsa030221.90836350
13RNA transport_Homo sapiens_hsa030131.76425301
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75678922
15Steroid biosynthesis_Homo sapiens_hsa001001.73873824
16One carbon pool by folate_Homo sapiens_hsa006701.72142086
17Nicotine addiction_Homo sapiens_hsa050331.64250353
18Non-homologous end-joining_Homo sapiens_hsa034501.60056054
19Pyrimidine metabolism_Homo sapiens_hsa002401.59197565
20Oocyte meiosis_Homo sapiens_hsa041141.57417794
21RNA polymerase_Homo sapiens_hsa030201.54692046
22mRNA surveillance pathway_Homo sapiens_hsa030151.52397556
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51649779
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46975955
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39969433
26Biosynthesis of amino acids_Homo sapiens_hsa012301.39275189
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.25115165
28Parkinsons disease_Homo sapiens_hsa050121.19719911
29Fatty acid elongation_Homo sapiens_hsa000621.18201760
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.16247288
31Regulation of autophagy_Homo sapiens_hsa041401.15054137
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14253020
33Oxidative phosphorylation_Homo sapiens_hsa001901.13951760
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11423885
35Huntingtons disease_Homo sapiens_hsa050161.08725548
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.03001811
37RNA degradation_Homo sapiens_hsa030180.99903019
38Synaptic vesicle cycle_Homo sapiens_hsa047210.98302010
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.97187433
40Lysine degradation_Homo sapiens_hsa003100.94294092
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91824603
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90829584
43Purine metabolism_Homo sapiens_hsa002300.90554759
44Fructose and mannose metabolism_Homo sapiens_hsa000510.90399691
45Phototransduction_Homo sapiens_hsa047440.89926409
46Proteasome_Homo sapiens_hsa030500.88906629
47Carbon metabolism_Homo sapiens_hsa012000.88839586
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88329990
49Pyruvate metabolism_Homo sapiens_hsa006200.79809160
50GABAergic synapse_Homo sapiens_hsa047270.79211707
51Protein export_Homo sapiens_hsa030600.78684657
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76211852
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71144657
54Selenocompound metabolism_Homo sapiens_hsa004500.69681594
55Ribosome_Homo sapiens_hsa030100.69492015
56Vibrio cholerae infection_Homo sapiens_hsa051100.68133496
57Gap junction_Homo sapiens_hsa045400.66859563
58Basal cell carcinoma_Homo sapiens_hsa052170.64234559
59Alcoholism_Homo sapiens_hsa050340.62633727
60Cardiac muscle contraction_Homo sapiens_hsa042600.62209624
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60554918
62Butanoate metabolism_Homo sapiens_hsa006500.55989397
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55082576
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51531910
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50909431
66N-Glycan biosynthesis_Homo sapiens_hsa005100.50415574
67Fatty acid metabolism_Homo sapiens_hsa012120.50275481
68Vitamin B6 metabolism_Homo sapiens_hsa007500.49797345
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49780632
70Taste transduction_Homo sapiens_hsa047420.49737660
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49408180
72Hedgehog signaling pathway_Homo sapiens_hsa043400.48703218
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.47967802
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47709668
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.46278704
76Cocaine addiction_Homo sapiens_hsa050300.46023588
77Pentose phosphate pathway_Homo sapiens_hsa000300.43803367
78Propanoate metabolism_Homo sapiens_hsa006400.43353608
79Alzheimers disease_Homo sapiens_hsa050100.42873219
80Metabolic pathways_Homo sapiens_hsa011000.41678049
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40789402
82Melanoma_Homo sapiens_hsa052180.40116700
83Axon guidance_Homo sapiens_hsa043600.39962198
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37950586
85Hippo signaling pathway_Homo sapiens_hsa043900.36281762
86AMPK signaling pathway_Homo sapiens_hsa041520.35208016
87Collecting duct acid secretion_Homo sapiens_hsa049660.34100329
88Glutamatergic synapse_Homo sapiens_hsa047240.33285604
89Wnt signaling pathway_Homo sapiens_hsa043100.32653258
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31928155
91Circadian entrainment_Homo sapiens_hsa047130.31594704
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30681954
93MicroRNAs in cancer_Homo sapiens_hsa052060.30054123
94Dopaminergic synapse_Homo sapiens_hsa047280.29260248
95Peroxisome_Homo sapiens_hsa041460.28834265
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.28350204
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.27524266
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27037866
99Morphine addiction_Homo sapiens_hsa050320.26603159
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23266068

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »