C1DP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)5.82105756
2mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.79975732
3mitochondrial respiratory chain complex I assembly (GO:0032981)4.79975732
4NADH dehydrogenase complex assembly (GO:0010257)4.79975732
5protein complex biogenesis (GO:0070271)4.66062990
6mitochondrial respiratory chain complex assembly (GO:0033108)4.53841708
7respiratory chain complex IV assembly (GO:0008535)4.51952513
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.51383124
9RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.51383124
10DNA double-strand break processing (GO:0000729)4.48361293
11DNA deamination (GO:0045006)4.44915949
12preassembly of GPI anchor in ER membrane (GO:0016254)4.08874287
13cullin deneddylation (GO:0010388)4.03978107
14adenosine metabolic process (GO:0046085)3.92121498
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.83027341
16platelet dense granule organization (GO:0060155)3.82655301
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77568354
18cytochrome complex assembly (GO:0017004)3.69195493
19resolution of meiotic recombination intermediates (GO:0000712)3.59046501
20ATP synthesis coupled proton transport (GO:0015986)3.56708161
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.56708161
22protein deneddylation (GO:0000338)3.54978678
23establishment of protein localization to mitochondrial membrane (GO:0090151)3.48095561
24kinetochore assembly (GO:0051382)3.46125742
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.45832162
26peptidyl-histidine modification (GO:0018202)3.43247906
27GPI anchor metabolic process (GO:0006505)3.42559659
28organelle disassembly (GO:1903008)3.42355701
29oxidative phosphorylation (GO:0006119)3.41499059
30pseudouridine synthesis (GO:0001522)3.40164275
31ribonucleoprotein complex disassembly (GO:0032988)3.40032266
32water-soluble vitamin biosynthetic process (GO:0042364)3.37164996
33DNA catabolic process, exonucleolytic (GO:0000738)3.36741973
34GPI anchor biosynthetic process (GO:0006506)3.34415749
35pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.33345605
36protein-cofactor linkage (GO:0018065)3.33316594
37CENP-A containing nucleosome assembly (GO:0034080)3.25944100
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.25732632
39branched-chain amino acid catabolic process (GO:0009083)3.25482113
40C-terminal protein lipidation (GO:0006501)3.25022071
41proteasome assembly (GO:0043248)3.24369070
42anterograde synaptic vesicle transport (GO:0048490)3.20449640
43chromatin remodeling at centromere (GO:0031055)3.19815509
44kinetochore organization (GO:0051383)3.18081376
45pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18069416
46rRNA modification (GO:0000154)3.16201694
47mitochondrial RNA metabolic process (GO:0000959)3.10793952
48mannosylation (GO:0097502)3.07047634
49tRNA processing (GO:0008033)3.04209859
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03491229
51DNA ligation (GO:0006266)3.02013693
52protein localization to cilium (GO:0061512)2.97705732
53deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.96778393
54C-terminal protein amino acid modification (GO:0018410)2.96508700
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96428993
56amino acid salvage (GO:0043102)2.94866352
57L-methionine salvage (GO:0071267)2.94866352
58L-methionine biosynthetic process (GO:0071265)2.94866352
59replication fork processing (GO:0031297)2.94177142
60GTP biosynthetic process (GO:0006183)2.93222965
61protein polyglutamylation (GO:0018095)2.90075606
62pteridine-containing compound biosynthetic process (GO:0042559)2.89108370
63protein neddylation (GO:0045116)2.86446501
64negative regulation of DNA-dependent DNA replication (GO:2000104)2.85804237
65regulation of helicase activity (GO:0051095)2.85742321
66histone mRNA metabolic process (GO:0008334)2.85660475
67regulation of mitochondrial translation (GO:0070129)2.82863950
68respiratory electron transport chain (GO:0022904)2.81437532
69electron transport chain (GO:0022900)2.79332643
70rRNA methylation (GO:0031167)2.77393478
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74201448
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74201448
73isotype switching (GO:0045190)2.74201448
74acrosome assembly (GO:0001675)2.72222851
75deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.69322018
76tRNA modification (GO:0006400)2.67637229
77mismatch repair (GO:0006298)2.66559161
78inositol phosphate catabolic process (GO:0071545)2.66163291
79double-strand break repair via nonhomologous end joining (GO:0006303)2.65327393
80non-recombinational repair (GO:0000726)2.65327393
81protein targeting to mitochondrion (GO:0006626)2.65288492
82tRNA metabolic process (GO:0006399)2.65270471
83inositol phosphate dephosphorylation (GO:0046855)2.64975271
84phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64975271
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64209763
86pyrimidine nucleotide catabolic process (GO:0006244)2.62185061
87glycolipid biosynthetic process (GO:0009247)2.59564192
88ubiquinone biosynthetic process (GO:0006744)2.57640895
89protein localization to mitochondrion (GO:0070585)2.57116136
90rRNA catabolic process (GO:0016075)2.56984123
91response to pheromone (GO:0019236)2.56851221
92deoxyribonucleotide catabolic process (GO:0009264)2.56725666
93RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56398630
94somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55925404
95somatic hypermutation of immunoglobulin genes (GO:0016446)2.55925404
96cellular ketone body metabolic process (GO:0046950)2.54496437
97recombinational repair (GO:0000725)2.53487535
98negative regulation of telomere maintenance (GO:0032205)2.52756180
99cellular response to interferon-beta (GO:0035458)2.50452460
100postreplication repair (GO:0006301)2.49890383

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.98607020
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.89257931
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.14581081
4ZNF274_21170338_ChIP-Seq_K562_Hela3.11684507
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94145943
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.74872585
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62823794
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60828485
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56612000
10VDR_23849224_ChIP-Seq_CD4+_Human2.50929573
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.44210584
12VDR_22108803_ChIP-Seq_LS180_Human2.40442494
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.37727677
14ELK1_19687146_ChIP-ChIP_HELA_Human2.34013874
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.24343492
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23736969
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18979075
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16794039
19FOXP3_21729870_ChIP-Seq_TREG_Human2.14106765
20PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08543551
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.04857617
22EWS_26573619_Chip-Seq_HEK293_Human2.03201782
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99348245
24IGF1R_20145208_ChIP-Seq_DFB_Human1.97894935
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97398375
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94472404
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91689652
28GBX2_23144817_ChIP-Seq_PC3_Human1.91056449
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87515137
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87415403
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87011057
32FUS_26573619_Chip-Seq_HEK293_Human1.84891651
33MYC_18940864_ChIP-ChIP_HL60_Human1.84743738
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81545084
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81472427
36P300_19829295_ChIP-Seq_ESCs_Human1.74104626
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70572650
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64264480
39CBP_20019798_ChIP-Seq_JUKART_Human1.64264480
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60139750
41TP53_22573176_ChIP-Seq_HFKS_Human1.58041390
42GABP_19822575_ChIP-Seq_HepG2_Human1.54863790
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54406511
44IRF8_22096565_ChIP-ChIP_GC-B_Human1.46155740
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45587724
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39913541
47ER_23166858_ChIP-Seq_MCF-7_Human1.36029609
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34240547
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.31988701
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31988701
51TAF15_26573619_Chip-Seq_HEK293_Human1.31547512
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.31201402
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31197419
54IRF1_19129219_ChIP-ChIP_H3396_Human1.29261713
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26986044
56NANOG_19829295_ChIP-Seq_ESCs_Human1.24634480
57SOX2_19829295_ChIP-Seq_ESCs_Human1.24634480
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.22736108
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21815615
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.21191467
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.18781303
62NCOR_22424771_ChIP-Seq_293T_Human1.18190533
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17269765
64HTT_18923047_ChIP-ChIP_STHdh_Human1.16872994
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15579579
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14815458
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14474402
68DCP1A_22483619_ChIP-Seq_HELA_Human1.14089808
69AR_20517297_ChIP-Seq_VCAP_Human1.13164064
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.12150704
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09798170
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.08210519
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08082800
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07832947
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04410495
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04323865
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04277202
78CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02510870
79CDX2_22108803_ChIP-Seq_LS180_Human1.02424166
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01985204
81BCAT_22108803_ChIP-Seq_LS180_Human1.01515097
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01509025
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98922513
84MYC_18555785_ChIP-Seq_MESCs_Mouse0.96103224
85SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95772486
86MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95532798
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94070367
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94025381
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93152685
90BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92806581
91TCF4_22108803_ChIP-Seq_LS180_Human0.92537559
92POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91505616
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91408266
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91172578
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90341676
96P53_22387025_ChIP-Seq_ESCs_Mouse0.90301842
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89720914
98FLI1_21867929_ChIP-Seq_TH2_Mouse0.89626882
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89491194
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89362269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis3.16918756
2MP0006054_spinal_hemorrhage3.11914542
3MP0002837_dystrophic_cardiac_calcinosis3.03866241
4MP0001529_abnormal_vocalization2.88024084
5MP0000516_abnormal_urinary_system2.65067894
6MP0005367_renal/urinary_system_phenotyp2.65067894
7MP0008058_abnormal_DNA_repair2.63538819
8MP0005646_abnormal_pituitary_gland2.49322889
9MP0008877_abnormal_DNA_methylation2.42620156
10MP0005645_abnormal_hypothalamus_physiol2.40915795
11MP0003806_abnormal_nucleotide_metabolis2.33409561
12MP0005084_abnormal_gallbladder_morpholo2.29719728
13MP0003195_calcinosis2.29098241
14MP0002736_abnormal_nociception_after2.27301971
15MP0004147_increased_porphyrin_level2.16822237
16MP0002102_abnormal_ear_morphology2.10721659
17MP0002234_abnormal_pharynx_morphology2.06328458
18MP0003186_abnormal_redox_activity2.05410305
19MP0000372_irregular_coat_pigmentation2.02183553
20MP0006036_abnormal_mitochondrial_physio1.99894847
21MP0003787_abnormal_imprinting1.99089984
22MP0003786_premature_aging1.95376519
23MP0006035_abnormal_mitochondrial_morpho1.93137377
24MP0000013_abnormal_adipose_tissue1.91612019
25MP0005253_abnormal_eye_physiology1.85704977
26MP0005332_abnormal_amino_acid1.76702974
27MP0004043_abnormal_pH_regulation1.72982763
28MP0010094_abnormal_chromosome_stability1.65517456
29MP0008995_early_reproductive_senescence1.61249527
30MP0003880_abnormal_central_pattern1.57829612
31MP0008007_abnormal_cellular_replicative1.57170097
32MP0001968_abnormal_touch/_nociception1.56633840
33MP0008872_abnormal_physiological_respon1.56281655
34MP0005360_urolithiasis1.52375006
35MP0001835_abnormal_antigen_presentation1.50299717
36MP0002822_catalepsy1.47474218
37MP0002163_abnormal_gland_morphology1.45343372
38MP0005551_abnormal_eye_electrophysiolog1.44926246
39MP0005075_abnormal_melanosome_morpholog1.40087278
40MP0009697_abnormal_copulation1.34220228
41MP0002938_white_spotting1.32227796
42MP0002254_reproductive_system_inflammat1.30468321
43MP0004133_heterotaxia1.28294665
44MP0006276_abnormal_autonomic_nervous1.27802298
45MP0009046_muscle_twitch1.27598262
46MP0001764_abnormal_homeostasis1.22815031
47MP0005636_abnormal_mineral_homeostasis1.20096388
48MP0005220_abnormal_exocrine_pancreas1.17871186
49MP0001984_abnormal_olfaction1.14498899
50MP0004142_abnormal_muscle_tone1.12027459
51MP0010386_abnormal_urinary_bladder1.10940451
52MP0006292_abnormal_olfactory_placode1.09967280
53MP0000358_abnormal_cell_content/1.09351557
54MP0003890_abnormal_embryonic-extraembry1.06415160
55MP0005671_abnormal_response_to1.00953663
56MP0002909_abnormal_adrenal_gland0.99465102
57MP0000631_abnormal_neuroendocrine_gland0.98964128
58MP0009745_abnormal_behavioral_response0.95825415
59MP0008789_abnormal_olfactory_epithelium0.95014898
60MP0003122_maternal_imprinting0.91876570
61MP0003718_maternal_effect0.91110767
62MP0002272_abnormal_nervous_system0.90823156
63MP0002751_abnormal_autonomic_nervous0.90547058
64MP0003137_abnormal_impulse_conducting0.89915491
65MP0001919_abnormal_reproductive_system0.89457202
66MP0005379_endocrine/exocrine_gland_phen0.87818336
67MP0005266_abnormal_metabolism0.87685241
68MP0004215_abnormal_myocardial_fiber0.87226750
69MP0002095_abnormal_skin_pigmentation0.86198223
70MP0001486_abnormal_startle_reflex0.85132237
71MP0003121_genomic_imprinting0.84910495
72MP0005499_abnormal_olfactory_system0.83786006
73MP0005394_taste/olfaction_phenotype0.83786006
74MP0001905_abnormal_dopamine_level0.76275028
75MP0003646_muscle_fatigue0.76137829
76MP0005389_reproductive_system_phenotype0.75856979
77MP0003633_abnormal_nervous_system0.75523011
78MP0002148_abnormal_hypersensitivity_rea0.74214714
79MP0002127_abnormal_cardiovascular_syste0.73750126
80MP0003724_increased_susceptibility_to0.73466997
81MP0001485_abnormal_pinna_reflex0.73212640
82MP0004924_abnormal_behavior0.72264429
83MP0005386_behavior/neurological_phenoty0.72264429
84MP0003011_delayed_dark_adaptation0.69899084
85MP0001756_abnormal_urination0.69695288
86MP0001929_abnormal_gametogenesis0.69639370
87MP0002734_abnormal_mechanical_nocicepti0.69325985
88MP0002693_abnormal_pancreas_physiology0.68618219
89MP0002735_abnormal_chemical_nociception0.68284122
90MP0001145_abnormal_male_reproductive0.67073027
91MP0000653_abnormal_sex_gland0.66831390
92MP0002277_abnormal_respiratory_mucosa0.66280060
93MP0001661_extended_life_span0.66102807
94MP0001970_abnormal_pain_threshold0.65525327
95MP0005174_abnormal_tail_pigmentation0.65328725
96MP0000639_abnormal_adrenal_gland0.64540471
97MP0008932_abnormal_embryonic_tissue0.64142177
98MP0002210_abnormal_sex_determination0.64015639
99MP0001944_abnormal_pancreas_morphology0.62701679
100MP0004885_abnormal_endolymph0.61931923

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic acidemia (HP:0002912)4.17290309
2Abnormality of alanine metabolism (HP:0010916)3.99767604
3Hyperalaninemia (HP:0003348)3.99767604
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.99767604
5Acute necrotizing encephalopathy (HP:0006965)3.87425654
6Abnormal mitochondria in muscle tissue (HP:0008316)3.56545163
7Progressive macrocephaly (HP:0004481)3.55924794
8Hepatocellular necrosis (HP:0001404)3.54149678
9Mitochondrial inheritance (HP:0001427)3.53178868
10Acute encephalopathy (HP:0006846)3.50077424
11Increased CSF lactate (HP:0002490)3.32538544
12Hepatic necrosis (HP:0002605)3.21437426
13Methylmalonic aciduria (HP:0012120)3.14573911
14Increased serum lactate (HP:0002151)3.04881600
15Constricted visual fields (HP:0001133)2.96938019
16Decreased electroretinogram (ERG) amplitude (HP:0000654)2.86808005
173-Methylglutaconic aciduria (HP:0003535)2.73929912
18Lactic acidosis (HP:0003128)2.72174113
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.72048475
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.72048475
21Abnormality of serum amino acid levels (HP:0003112)2.70339380
22Failure to thrive in infancy (HP:0001531)2.67754753
23Abnormality of vitamin B metabolism (HP:0004340)2.67533073
24Cerebral edema (HP:0002181)2.64407148
25Double outlet right ventricle (HP:0001719)2.59679354
26Congenital malformation of the right heart (HP:0011723)2.59679354
27Ketoacidosis (HP:0001993)2.51429702
28Colon cancer (HP:0003003)2.41909009
29Thyroiditis (HP:0100646)2.41296051
30Abnormality of the vitamin B12 metabolism (HP:0004341)2.38380452
31Hyperglycinemia (HP:0002154)2.38253255
32Pancreatic cysts (HP:0001737)2.34403251
33Congenital, generalized hypertrichosis (HP:0004540)2.26292738
34Nephronophthisis (HP:0000090)2.24728277
35Abolished electroretinogram (ERG) (HP:0000550)2.24120957
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.22396073
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20922937
38Attenuation of retinal blood vessels (HP:0007843)2.20613290
39Pancreatic fibrosis (HP:0100732)2.18921120
40Severe combined immunodeficiency (HP:0004430)2.18179255
41Lethargy (HP:0001254)2.16402814
42Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16173353
43Dicarboxylic aciduria (HP:0003215)2.16173353
44Respiratory failure (HP:0002878)2.14909093
45Lipid accumulation in hepatocytes (HP:0006561)2.14501756
46Type II lissencephaly (HP:0007260)2.10755486
47Neoplasm of the adrenal gland (HP:0100631)2.02681665
48Medial flaring of the eyebrow (HP:0010747)2.01278138
49Congenital sensorineural hearing impairment (HP:0008527)2.01000781
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98688647
51Aplastic anemia (HP:0001915)1.97671134
52Delayed CNS myelination (HP:0002188)1.96781045
53Focal motor seizures (HP:0011153)1.96344987
54Increased hepatocellular lipid droplets (HP:0006565)1.96257478
55Hypothermia (HP:0002045)1.95545496
56Dynein arm defect of respiratory motile cilia (HP:0012255)1.95392390
57Absent/shortened dynein arms (HP:0200106)1.95392390
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93741344
59Exercise intolerance (HP:0003546)1.93189308
60Neoplasm of the adrenal cortex (HP:0100641)1.93182663
61Meckel diverticulum (HP:0002245)1.92999815
62CNS demyelination (HP:0007305)1.90418194
63Abnormality of the preputium (HP:0100587)1.90188766
64Leukodystrophy (HP:0002415)1.89812007
65Abnormality of chromosome stability (HP:0003220)1.88678525
66Abnormality of glycine metabolism (HP:0010895)1.88425549
67Abnormality of serine family amino acid metabolism (HP:0010894)1.88425549
68Optic disc pallor (HP:0000543)1.85618372
69Ketosis (HP:0001946)1.84451002
70True hermaphroditism (HP:0010459)1.83787884
71Intestinal atresia (HP:0011100)1.82973567
72Renal cortical cysts (HP:0000803)1.82436679
73Abnormal respiratory epithelium morphology (HP:0012253)1.82023626
74Abnormal respiratory motile cilium morphology (HP:0005938)1.82023626
75Abnormality of the ileum (HP:0001549)1.81499406
76Dry hair (HP:0011359)1.81002608
77Combined immunodeficiency (HP:0005387)1.79056183
78Hyperglycinuria (HP:0003108)1.76891744
79Stomatitis (HP:0010280)1.76886163
80Elevated erythrocyte sedimentation rate (HP:0003565)1.76484138
81Abnormal protein glycosylation (HP:0012346)1.75750951
82Abnormal glycosylation (HP:0012345)1.75750951
83Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75750951
84Abnormal protein N-linked glycosylation (HP:0012347)1.75750951
85Abnormality of the renal medulla (HP:0100957)1.75611614
86Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75223420
87Abnormality of the labia minora (HP:0012880)1.74842585
88Exertional dyspnea (HP:0002875)1.74429132
89Hypoplasia of the fovea (HP:0007750)1.71020999
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.71020999
91Progressive inability to walk (HP:0002505)1.70912616
92Abnormality of the renal cortex (HP:0011035)1.70657488
93Type I transferrin isoform profile (HP:0003642)1.69618107
94Petechiae (HP:0000967)1.68883888
95Decreased central vision (HP:0007663)1.68605185
96Aplasia/hypoplasia of the uterus (HP:0008684)1.68337463
97Metabolic acidosis (HP:0001942)1.68280838
98Lissencephaly (HP:0001339)1.67596907
99Agitation (HP:0000713)1.67498781
100Supernumerary spleens (HP:0009799)1.66550802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.79209424
2NUAK13.49635014
3VRK23.48410287
4FRK3.33761161
5MST42.78427159
6WNK32.53823640
7EIF2AK32.51506390
8TAF12.27910370
9MAP3K122.21610116
10TAOK32.11729822
11TRIM282.06493934
12CSNK1G31.96706960
13BMPR1B1.93936030
14CSNK1G21.93405923
15ZAK1.83484621
16NEK11.70193760
17PLK21.69959305
18VRK11.68107285
19EIF2AK11.65794107
20CSNK1G11.57693530
21CSNK1A1L1.53440892
22PLK31.53015810
23ACVR1B1.51929070
24ADRBK21.47750573
25TXK1.42509748
26TLK11.40979164
27ERBB31.36971673
28MAP3K41.31386961
29DYRK21.27767022
30BCKDK1.26297510
31STK161.26208143
32GRK11.24540465
33TSSK61.16577946
34MAPK131.15087438
35DAPK11.11901988
36EIF2AK21.10693077
37PLK41.09352260
38MAP2K71.06128726
39SRPK11.02448184
40BCR1.01196181
41KIT0.99602849
42STK38L0.98986796
43OXSR10.90984669
44DAPK20.84231773
45TEC0.83988729
46BRSK20.82807213
47TNIK0.82780072
48INSRR0.81929477
49PINK10.80833493
50CAMKK20.79655757
51WEE10.77472761
52GRK50.75747168
53PRKCE0.73104330
54ATR0.68401241
55IKBKB0.67881369
56PRKCI0.67549821
57STK30.66306778
58MAPKAPK50.65241454
59MKNK10.64775727
60FLT30.58431525
61FGFR30.58208272
62MINK10.55958450
63MAP2K60.55171027
64WNK40.55152212
65CHEK20.53515743
66ADRBK10.52983181
67GRK70.50782610
68CCNB10.49729269
69MKNK20.49083709
70PASK0.48979518
71OBSCN0.48710140
72TIE10.47823290
73MAP2K30.47169091
74CDC70.46709085
75RPS6KA50.46153401
76MAP2K40.45644806
77CDK30.45498556
78PIK3CG0.44159116
79PLK10.44083767
80MYLK0.44055030
81PAK30.42962963
82CDK90.42725970
83SCYL20.42171954
84TGFBR10.41403293
85BUB10.41320224
86CSNK1A10.39258315
87ABL20.38690211
88PHKG20.35911283
89PHKG10.35911283
90DAPK30.35844532
91CSNK2A10.35587686
92MAP3K50.33105461
93ATM0.31832456
94FER0.31768923
95CAMK2A0.31597241
96STK390.31218234
97DYRK1A0.30662105
98LYN0.30483086
99IRAK10.29551816
100CAMK2D0.27802239

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.90785787
2Oxidative phosphorylation_Homo sapiens_hsa001903.13455646
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.97424360
4Proteasome_Homo sapiens_hsa030502.84626511
5Non-homologous end-joining_Homo sapiens_hsa034502.77415735
6Sulfur metabolism_Homo sapiens_hsa009202.42344720
7Propanoate metabolism_Homo sapiens_hsa006402.30772778
8Parkinsons disease_Homo sapiens_hsa050122.28857147
9Fanconi anemia pathway_Homo sapiens_hsa034602.12810994
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09986219
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.04463511
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03309338
13Homologous recombination_Homo sapiens_hsa034402.03066815
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.95318855
15Basal transcription factors_Homo sapiens_hsa030221.91218022
16One carbon pool by folate_Homo sapiens_hsa006701.87324827
17Asthma_Homo sapiens_hsa053101.81053036
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77585254
19Mismatch repair_Homo sapiens_hsa034301.77326203
20Collecting duct acid secretion_Homo sapiens_hsa049661.74155412
21RNA degradation_Homo sapiens_hsa030181.60169788
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55287039
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.52762115
24Type I diabetes mellitus_Homo sapiens_hsa049401.48755031
25Alzheimers disease_Homo sapiens_hsa050101.46159206
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44344217
27Phototransduction_Homo sapiens_hsa047441.43730159
28Fatty acid elongation_Homo sapiens_hsa000621.38431157
29Huntingtons disease_Homo sapiens_hsa050161.37240228
30Butanoate metabolism_Homo sapiens_hsa006501.37050728
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.33752372
32Peroxisome_Homo sapiens_hsa041461.28919339
33Pyrimidine metabolism_Homo sapiens_hsa002401.25534417
34RNA polymerase_Homo sapiens_hsa030201.23518895
35DNA replication_Homo sapiens_hsa030301.22903245
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22020225
37Nucleotide excision repair_Homo sapiens_hsa034201.20947066
38Regulation of autophagy_Homo sapiens_hsa041401.18540982
39Spliceosome_Homo sapiens_hsa030401.13487412
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12814879
41Nicotine addiction_Homo sapiens_hsa050331.12537821
42Tryptophan metabolism_Homo sapiens_hsa003801.08986241
43Graft-versus-host disease_Homo sapiens_hsa053321.06202905
44Allograft rejection_Homo sapiens_hsa053301.03926288
45Autoimmune thyroid disease_Homo sapiens_hsa053201.01984888
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99403455
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96480179
48Selenocompound metabolism_Homo sapiens_hsa004500.96145149
49Purine metabolism_Homo sapiens_hsa002300.91942863
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88211821
51Rheumatoid arthritis_Homo sapiens_hsa053230.86146077
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85781299
53GABAergic synapse_Homo sapiens_hsa047270.82665102
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81565043
55Sulfur relay system_Homo sapiens_hsa041220.81436387
56Base excision repair_Homo sapiens_hsa034100.81132758
57RNA transport_Homo sapiens_hsa030130.80934199
58Metabolic pathways_Homo sapiens_hsa011000.80761547
59Ether lipid metabolism_Homo sapiens_hsa005650.80205430
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79407671
61Glutathione metabolism_Homo sapiens_hsa004800.76783842
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74360043
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73997137
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73411802
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71901936
66Linoleic acid metabolism_Homo sapiens_hsa005910.71858656
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70493564
68Steroid biosynthesis_Homo sapiens_hsa001000.69190143
69Folate biosynthesis_Homo sapiens_hsa007900.68539135
70Nitrogen metabolism_Homo sapiens_hsa009100.67777797
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67611581
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66561207
73Retinol metabolism_Homo sapiens_hsa008300.65896732
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62841622
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62358257
76Pyruvate metabolism_Homo sapiens_hsa006200.61981600
77Morphine addiction_Homo sapiens_hsa050320.61322528
78Taste transduction_Homo sapiens_hsa047420.60197542
79Caffeine metabolism_Homo sapiens_hsa002320.57879445
80Arachidonic acid metabolism_Homo sapiens_hsa005900.56552956
81beta-Alanine metabolism_Homo sapiens_hsa004100.56119646
82Primary immunodeficiency_Homo sapiens_hsa053400.55764171
83Fatty acid degradation_Homo sapiens_hsa000710.55537291
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55148208
85Chemical carcinogenesis_Homo sapiens_hsa052040.55106871
86Fatty acid metabolism_Homo sapiens_hsa012120.51180547
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50964173
88Olfactory transduction_Homo sapiens_hsa047400.49837973
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49340573
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48739524
91Antigen processing and presentation_Homo sapiens_hsa046120.48665036
92Cardiac muscle contraction_Homo sapiens_hsa042600.47089964
93Vitamin B6 metabolism_Homo sapiens_hsa007500.40781272
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38179139
95Serotonergic synapse_Homo sapiens_hsa047260.36552786
96Legionellosis_Homo sapiens_hsa051340.32797283
97Carbon metabolism_Homo sapiens_hsa012000.32128189
98Systemic lupus erythematosus_Homo sapiens_hsa053220.31829166
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.31688480
100Herpes simplex infection_Homo sapiens_hsa051680.29356844

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