ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	6.36824308
2	oocyte development (GO:0048599)	6.32482613
3	male meiosis I (GO:0007141)	6.02830229
4	regulation of acrosome reaction (GO:0060046)	5.82697280
5	regulation of exit from mitosis (GO:0007096)	5.53498784
6	meiosis I (GO:0007127)	5.06462745
7	regulation of RIG-I signaling pathway (GO:0039535)	4.99155734
8	transcription from mitochondrial promoter (GO:0006390)	4.97012367
9	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.92147439
10	histone lysine demethylation (GO:0070076)	4.83191109
11	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.81439326
12	synaptonemal complex organization (GO:0070193)	4.81317124
13	protein K6-linked ubiquitination (GO:0085020)	4.77883696
14	positive regulation of catecholamine secretion (GO:0033605)	4.77726125
15	N-terminal protein amino acid acetylation (GO:0006474)	4.66685029
16	histone demethylation (GO:0016577)	4.62763849
17	synaptonemal complex assembly (GO:0007130)	4.59600696
18	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.54641126
19	regulation of female receptivity (GO:0045924)	4.50216766
20	response to UV-C (GO:0010225)	4.48563156
21	positive regulation of meiosis (GO:0045836)	4.38480008
22	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.34012483
23	positive regulation of meiotic cell cycle (GO:0051446)	4.31783043
24	reproduction (GO:0000003)	4.26552524
25	male meiosis (GO:0007140)	4.22252863
26	gonadal mesoderm development (GO:0007506)	4.16580512
27	protein dealkylation (GO:0008214)	4.16469886
28	protein demethylation (GO:0006482)	4.16469886
29	single fertilization (GO:0007338)	4.11742846
30	binding of sperm to zona pellucida (GO:0007339)	4.05648152
31	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.87602434
32	female mating behavior (GO:0060180)	3.84518352
33	maturation of SSU-rRNA (GO:0030490)	3.74264142
34	regulation of uterine smooth muscle contraction (GO:0070472)	3.71070951
35	acrosome reaction (GO:0007340)	3.70832832
36	aggressive behavior (GO:0002118)	3.67986137
37	protein kinase C signaling (GO:0070528)	3.59488998
38	autophagic vacuole assembly (GO:0000045)	3.57549305
39	drinking behavior (GO:0042756)	3.56565443
40	positive regulation of digestive system process (GO:0060456)	3.48288516
41	motile cilium assembly (GO:0044458)	3.45816195
42	negative regulation of Ras GTPase activity (GO:0034261)	3.45545027
43	negative regulation of reproductive process (GO:2000242)	3.36881292
44	mitochondrial RNA metabolic process (GO:0000959)	3.35034128
45	positive regulation of prostaglandin secretion (GO:0032308)	3.28760846
46	mitotic metaphase plate congression (GO:0007080)	3.27563296
47	rRNA modification (GO:0000154)	3.25468449
48	regulation of DNA methylation (GO:0044030)	3.25219942
49	regulation of penile erection (GO:0060405)	3.23702967
50	regulation of female gonad development (GO:2000194)	3.22464207
51	positive regulation of humoral immune response (GO:0002922)	3.19822527
52	fertilization (GO:0009566)	3.19220171
53	sperm-egg recognition (GO:0035036)	3.17082016
54	meiotic cell cycle (GO:0051321)	3.16246047
55	hyperosmotic salinity response (GO:0042538)	3.14501772
56	negative regulation of digestive system process (GO:0060457)	3.13679828
57	meiotic cell cycle process (GO:1903046)	3.12527811
58	piRNA metabolic process (GO:0034587)	3.10039090
59	skeletal muscle tissue regeneration (GO:0043403)	3.05957065
60	regulation of mRNA splicing, via spliceosome (GO:0048024)	3.05880991
61	intestinal epithelial cell development (GO:0060576)	3.05302633
62	chromosome organization involved in meiosis (GO:0070192)	3.05162640
63	sleep (GO:0030431)	3.04309945
64	regulation of prostaglandin secretion (GO:0032306)	3.00838129
65	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	25.1000446
66	regulation of retinoic acid receptor signaling pathway (GO:0048385)	21.0698055
67	positive regulation of protein homooligomerization (GO:0032464)	2.99578254
68	chaperone-mediated protein transport (GO:0072321)	2.93139960
69	positive regulation of histone H3-K4 methylation (GO:0051571)	2.84298704
70	RNA localization (GO:0006403)	2.83857527
71	attachment of spindle microtubules to kinetochore (GO:0008608)	2.80483399
72	centriole assembly (GO:0098534)	2.79382916
73	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.78410332
74	striated muscle atrophy (GO:0014891)	2.76852377
75	regulation of meiosis (GO:0040020)	2.76030391
76	ventricular cardiac muscle cell development (GO:0055015)	2.72047877
77	positive regulation of reproductive process (GO:2000243)	2.71301282
78	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.70610649
79	N-terminal protein amino acid modification (GO:0031365)	2.69012791
80	meiotic nuclear division (GO:0007126)	2.68831598
81	regulation of helicase activity (GO:0051095)	2.68083866
82	regulation of mRNA processing (GO:0050684)	2.68026826
83	ribosomal small subunit biogenesis (GO:0042274)	2.67650820
84	calcium ion-dependent exocytosis (GO:0017156)	2.66946052
85	regulation of RNA splicing (GO:0043484)	2.64637119
86	termination of RNA polymerase III transcription (GO:0006386)	2.64524931
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.64524931
88	maternal behavior (GO:0042711)	2.60873362
89	muscle atrophy (GO:0014889)	2.60525484
90	negative regulation of mRNA processing (GO:0050686)	2.58935781
91	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.56590355
92	rRNA methylation (GO:0031167)	2.55815901
93	cell-cell recognition (GO:0009988)	2.53168049
94	protein K48-linked deubiquitination (GO:0071108)	2.52119274
95	poly(A)+ mRNA export from nucleus (GO:0016973)	2.52083312
96	DNA replication-dependent nucleosome organization (GO:0034723)	2.42771256
97	DNA replication-dependent nucleosome assembly (GO:0006335)	2.42771256
98	regulation of G0 to G1 transition (GO:0070316)	2.41402582
99	metaphase plate congression (GO:0051310)	2.40384105
100	histone H3-K9 demethylation (GO:0033169)	12.9184024

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	8.00363390
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.76454643
3	EZH2_22144423_ChIP-Seq_EOC_Human	4.29437247
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.87853290
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.35320382
6	VDR_22108803_ChIP-Seq_LS180_Human	3.34093666
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.01577751
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.01531240
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.00318416
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.72206715
11	E2F7_22180533_ChIP-Seq_HELA_Human	2.67368903
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.59697378
13	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.58961151
14	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.58961151
15	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.58961151
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.44670559
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.40749038
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.33631436
19	ZNF274_21170338_ChIP-Seq_K562_Hela	2.26182006
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24873113
21	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.23905701
22	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.20027750
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.14780672
24	AR_21909140_ChIP-Seq_LNCAP_Human	2.09189476
25	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.00696384
26	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.96028753
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.94492775
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.83105267
29	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.79573569
30	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.77874555
31	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77587221
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.73007497
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.72975875
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.72239936
35	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.66800487
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64028564
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.57253668
38	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.49149658
39	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.44392421
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.42272902
41	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.42272062
42	CBP_21632823_ChIP-Seq_H3396_Human	1.39310109
43	GBX2_23144817_ChIP-Seq_PC3_Human	1.39292267
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.37711039
45	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.35597931
46	NCOR_22424771_ChIP-Seq_293T_Human	1.33603511
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32946832
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.28906479
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.28818513
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.27126494
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26870907
52	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.26644808
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.26145062
54	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.23405123
55	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.23370495
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21612404
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.17719568
58	TCF4_23295773_ChIP-Seq_U87_Human	1.15446963
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.12917626
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.12163335
61	RAC3_21632823_ChIP-Seq_H3396_Human	1.11317245
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.10573056
63	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10075811
64	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.09265229
65	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09174570
66	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06887924
67	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.06037451
68	GATA3_26560356_Chip-Seq_TH1_Human	1.05735413
69	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.04523497
70	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.03552244
71	GABP_19822575_ChIP-Seq_HepG2_Human	0.99939379
72	TAF15_26573619_Chip-Seq_HEK293_Human	0.99922983
73	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95374236
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95219348
75	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.95000729
76	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.94456754
77	P300_19829295_ChIP-Seq_ESCs_Human	0.93996206
78	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.93839912
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92609894
80	BCAT_22108803_ChIP-Seq_LS180_Human	0.91583214
81	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91037778
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.90961838
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.90871178
84	STAT3_23295773_ChIP-Seq_U87_Human	0.89708362
85	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.87793794
86	TBL1_22424771_ChIP-Seq_293T_Human	0.86569842
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.86255634
88	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.86217121
89	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.85043377
90	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.84167536
91	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.83610263
92	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.83430015
93	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.83217939
94	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.83200196
95	GF1_26923725_Chip-Seq_HPCs_Mouse	0.82285789
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.81743195
97	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.80963703
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.80780727
99	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.80066285
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.79776627

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.59646400
2	MP0001986_abnormal_taste_sensitivity	4.32299313
3	MP0009379_abnormal_foot_pigmentation	4.28022477
4	MP0005423_abnormal_somatic_nervous	4.16153129
5	MP0003693_abnormal_embryo_hatching	3.65073282
6	MP0003283_abnormal_digestive_organ	3.44672339
7	MP0002160_abnormal_reproductive_system	3.32843100
8	MP0003950_abnormal_plasma_membrane	3.05766377
9	MP0000678_abnormal_parathyroid_gland	3.03410470
10	MP0003136_yellow_coat_color	2.99279098
11	MP0009840_abnormal_foam_cell	2.68817813
12	MP0005410_abnormal_fertilization	2.64792889
13	MP0003718_maternal_effect	2.59704055
14	MP0001929_abnormal_gametogenesis	2.44869844
15	MP0008058_abnormal_DNA_repair	2.41512705
16	MP0002210_abnormal_sex_determination	2.23429271
17	MP0000427_abnormal_hair_cycle	2.22822167
18	MP0005360_urolithiasis	2.18830308
19	MP0010094_abnormal_chromosome_stability	2.11749892
20	MP0006276_abnormal_autonomic_nervous	2.07662383
21	MP0010307_abnormal_tumor_latency	2.06103571
22	MP0003077_abnormal_cell_cycle	1.89369299
23	MP0005389_reproductive_system_phenotype	1.85910503
24	MP0003699_abnormal_female_reproductive	1.83196674
25	MP0003111_abnormal_nucleus_morphology	1.79718213
26	MP0001502_abnormal_circadian_rhythm	1.76406324
27	MP0001666_abnormal_nutrient_absorption	1.76363505
28	MP0005647_abnormal_sex_gland	1.73955330
29	MP0008877_abnormal_DNA_methylation	1.72088178
30	MP0002127_abnormal_cardiovascular_syste	1.66736269
31	MP0000372_irregular_coat_pigmentation	1.64074051
32	MP0003646_muscle_fatigue	1.55795395
33	MP0005220_abnormal_exocrine_pancreas	1.55648308
34	MP0003938_abnormal_ear_development	1.54938168
35	MP0000653_abnormal_sex_gland	1.53167605
36	MP0002277_abnormal_respiratory_mucosa	1.49842783
37	MP0000049_abnormal_middle_ear	1.48895187
38	MP0003119_abnormal_digestive_system	1.48713063
39	MP0004957_abnormal_blastocyst_morpholog	1.47347075
40	MP0002751_abnormal_autonomic_nervous	1.43883566
41	MP0005646_abnormal_pituitary_gland	1.42593424
42	MP0003698_abnormal_male_reproductive	1.34113955
43	MP0002161_abnormal_fertility/fecundity	1.25990937
44	MP0001119_abnormal_female_reproductive	1.25299714
45	MP0003866_abnormal_defecation	1.24118360
46	MP0001145_abnormal_male_reproductive	1.22834004
47	MP0001664_abnormal_digestion	1.21490358
48	MP0001730_embryonic_growth_arrest	1.20470686
49	MP0003890_abnormal_embryonic-extraembry	1.12076002
50	MP0003936_abnormal_reproductive_system	1.10747187
51	MP0000350_abnormal_cell_proliferation	1.07308540
52	MP0003868_abnormal_feces_composition	1.05640942
53	MP0008260_abnormal_autophagy	1.05566094
54	MP0001881_abnormal_mammary_gland	1.05198872
55	MP0002163_abnormal_gland_morphology	0.99955099
56	MP0000462_abnormal_digestive_system	0.98486540
57	MP0000631_abnormal_neuroendocrine_gland	0.90659960
58	MP0001440_abnormal_grooming_behavior	0.90626954
59	MP0005499_abnormal_olfactory_system	0.89323465
60	MP0005394_taste/olfaction_phenotype	0.89323465
61	MP0010368_abnormal_lymphatic_system	0.88146151
62	MP0003121_genomic_imprinting	0.83577524
63	MP0010030_abnormal_orbit_morphology	0.81848505
64	MP0004233_abnormal_muscle_weight	0.81489975
65	MP0000470_abnormal_stomach_morphology	0.78760244
66	MP0006036_abnormal_mitochondrial_physio	0.78722697
67	MP0001286_abnormal_eye_development	0.78350272
68	MP0003183_abnormal_peptide_metabolism	0.78191317
69	MP0008932_abnormal_embryonic_tissue	0.77914988
70	MP0002102_abnormal_ear_morphology	0.76035135
71	MP0002090_abnormal_vision	0.74190797
72	MP0005380_embryogenesis_phenotype	0.73798467
73	MP0001672_abnormal_embryogenesis/_devel	0.73798467
74	MP0002095_abnormal_skin_pigmentation	0.73549095
75	MP0002396_abnormal_hematopoietic_system	0.69835779
76	MP0002269_muscular_atrophy	0.68770596
77	MP0003879_abnormal_hair_cell	0.67027267
78	MP0003880_abnormal_central_pattern	0.66089815
79	MP0006072_abnormal_retinal_apoptosis	0.66013275
80	MP0003786_premature_aging	0.65390070
81	MP0002085_abnormal_embryonic_tissue	0.64854439
82	MP0000627_abnormal_mammary_gland	0.64426406
83	MP0004215_abnormal_myocardial_fiber	0.63448173
84	MP0004019_abnormal_vitamin_homeostasis	0.63086043
85	MP0005395_other_phenotype	0.62506792
86	MP0002184_abnormal_innervation	0.60452298
87	MP0000230_abnormal_systemic_arterial	0.59796423
88	MP0004043_abnormal_pH_regulation	0.59633989
89	MP0009333_abnormal_splenocyte_physiolog	0.57539503
90	MP0005645_abnormal_hypothalamus_physiol	0.57404550
91	MP0004270_analgesia	0.56715837
92	MP0001697_abnormal_embryo_size	0.56568639
93	MP0008789_abnormal_olfactory_epithelium	0.55455641
94	MP0000647_abnormal_sebaceous_gland	0.54521127
95	MP0001944_abnormal_pancreas_morphology	0.54121684
96	MP0000733_abnormal_muscle_development	0.54059110
97	MP0002332_abnormal_exercise_endurance	0.53417128
98	MP0005551_abnormal_eye_electrophysiolog	0.52850061
99	MP0002229_neurodegeneration	0.52524756
100	MP0003959_abnormal_lean_body	0.51995298

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	7.24727109
2	Male infertility (HP:0003251)	5.63117980
3	Short tibia (HP:0005736)	5.12955729
4	Aplasia/Hypoplasia of the tibia (HP:0005772)	4.83655798
5	Median cleft lip (HP:0000161)	4.33038897
6	Microglossia (HP:0000171)	4.23810882
7	Facial cleft (HP:0002006)	3.98421118
8	Abnormal number of incisors (HP:0011064)	3.57697474
9	Oligodactyly (hands) (HP:0001180)	3.53032005
10	Abnormal pancreas size (HP:0012094)	3.49526047
11	Hyperphosphatemia (HP:0002905)	3.22682371
12	Tetany (HP:0001281)	3.21105118
13	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	3.06002157
14	Adrenal hypoplasia (HP:0000835)	3.01136622
15	Microretrognathia (HP:0000308)	3.00384276
16	Double outlet right ventricle (HP:0001719)	2.93456464
17	Congenital malformation of the right heart (HP:0011723)	2.93456464
18	Atonic seizures (HP:0010819)	2.84007054
19	Abnormality of the nasal septum (HP:0000419)	2.81997879
20	Anhidrosis (HP:0000970)	2.71778803
21	Glossoptosis (HP:0000162)	2.71531802
22	Chromsome breakage (HP:0040012)	2.69115067
23	Abnormality of the fetal cardiovascular system (HP:0010948)	2.65876026
24	Abnormal umbilical cord blood vessels (HP:0011403)	2.65876026
25	Single umbilical artery (HP:0001195)	2.65876026
26	Congenital sensorineural hearing impairment (HP:0008527)	2.65316810
27	Impulsivity (HP:0100710)	2.64180124
28	Tetraparesis (HP:0002273)	2.62127243
29	Metaphyseal dysplasia (HP:0100255)	2.57117575
30	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.52368488
31	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.52368488
32	Birth length less than 3rd percentile (HP:0003561)	2.52075546
33	Oligodactyly (HP:0012165)	2.51320743
34	Abnormal auditory evoked potentials (HP:0006958)	2.50343168
35	Short chin (HP:0000331)	2.48400594
36	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.48312645
37	Rhinitis (HP:0012384)	2.48172816
38	Hypercortisolism (HP:0001578)	2.48104464
39	Reticulocytopenia (HP:0001896)	2.46384016
40	Abdominal situs inversus (HP:0003363)	2.43420493
41	Abnormality of abdominal situs (HP:0011620)	2.43420493
42	Ectopic kidney (HP:0000086)	2.41730564
43	Meckel diverticulum (HP:0002245)	2.39257240
44	Abnormality of the ileum (HP:0001549)	2.35795723
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.33883540
46	Patent foramen ovale (HP:0001655)	2.33117998
47	Abnormality of chromosome stability (HP:0003220)	2.32984710
48	Multiple enchondromatosis (HP:0005701)	2.31089185
49	Abnormality of the preputium (HP:0100587)	2.30820093
50	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.30769459
51	Infertility (HP:0000789)	2.29584998
52	Sensory axonal neuropathy (HP:0003390)	2.27639462
53	Absent thumb (HP:0009777)	2.26968832
54	Renal Fanconi syndrome (HP:0001994)	2.24679827
55	Hypoplasia of the radius (HP:0002984)	2.24202852
56	Submucous cleft hard palate (HP:0000176)	2.23531115
57	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.21294642
58	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20259721
59	Cleft eyelid (HP:0000625)	2.19145188
60	Abnormality of lateral ventricle (HP:0030047)	2.18001084
61	Abnormality of the corticospinal tract (HP:0002492)	2.16192845
62	Osteomalacia (HP:0002749)	2.15013583
63	Abnormal ciliary motility (HP:0012262)	2.14447993
64	Supernumerary spleens (HP:0009799)	2.13210571
65	Maternal diabetes (HP:0009800)	2.11302664
66	Preauricular pit (HP:0004467)	2.09545140
67	Periauricular skin pits (HP:0100277)	2.09545140
68	Hyperalaninemia (HP:0003348)	2.07884372
69	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.07884372
70	Abnormality of alanine metabolism (HP:0010916)	2.07884372
71	Short thumb (HP:0009778)	2.06255590
72	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.06079970
73	Constricted visual fields (HP:0001133)	2.05936102
74	Prostate neoplasm (HP:0100787)	2.05120507
75	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03644723
76	Absent/shortened dynein arms (HP:0200106)	2.03644723
77	Amelogenesis imperfecta (HP:0000705)	2.03502668
78	Myokymia (HP:0002411)	2.02135756
79	Anterior segment dysgenesis (HP:0007700)	1.99719419
80	Bony spicule pigmentary retinopathy (HP:0007737)	1.98418187
81	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.98133277
82	Increased hepatocellular lipid droplets (HP:0006565)	1.96136852
83	Increased CSF lactate (HP:0002490)	1.96116447
84	Abnormality of cells of the erythroid lineage (HP:0012130)	1.94521144
85	Abnormal respiratory motile cilium physiology (HP:0012261)	1.94193324
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.94034471
87	Abnormality of the incisor (HP:0000676)	1.91916050
88	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.90997038
89	Hypoplasia of the fovea (HP:0007750)	1.90997038
90	Type I diabetes mellitus (HP:0100651)	1.88464992
91	Concave nail (HP:0001598)	1.86460834
92	Pancreatic fibrosis (HP:0100732)	1.85735586
93	Microvesicular hepatic steatosis (HP:0001414)	1.85339352
94	Hypophosphatemic rickets (HP:0004912)	1.83737153
95	Exertional dyspnea (HP:0002875)	1.82449098
96	Carpal bone hypoplasia (HP:0001498)	1.82414415
97	Pili torti (HP:0003777)	1.82323931
98	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.76018306
99	Abnormality of the labia minora (HP:0012880)	1.71747485
100	Glycosuria (HP:0003076)	1.70716102

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	6.74981351
2	TESK2	3.34759957
3	SRPK1	3.25696796
4	CDK19	3.24657386
5	TAOK3	3.19270938
6	LATS2	3.08314825
7	BUB1	2.98431066
8	TNIK	2.95673939
9	AURKA	2.84317505
10	PLK4	2.82287865
11	CDK12	2.75570472
12	VRK1	2.02099800
13	ZAK	1.89796471
14	TLK1	1.83542382
15	TRIM28	1.83111519
16	STK39	1.74807278
17	ACVR1B	1.71733499
18	PLK1	1.71211477
19	CHEK2	1.68833261
20	PBK	1.64637528
21	AURKB	1.55408124
22	BMPR1B	1.54222706
23	CDC7	1.40166944
24	TTK	1.40063432
25	NUAK1	1.39415727
26	PKN1	1.39062899
27	VRK2	1.29510364
28	EPHA4	1.26625275
29	BRSK2	1.24175232
30	BRSK1	1.21891244
31	WNK1	1.15996986
32	MELK	1.12349030
33	PIM2	1.09536057
34	PLK3	1.06914323
35	CDK7	1.03976466
36	TEC	1.02722259
37	NLK	0.96210844
38	ICK	0.89690932
39	CHEK1	0.88299254
40	OXSR1	0.87050649
41	NEK6	0.84881404
42	MAP3K3	0.81997274
43	MARK3	0.79867539
44	PLK2	0.74663267
45	MAP2K3	0.73903546
46	STK10	0.69651331
47	BMX	0.69582563
48	LATS1	0.68998609
49	EIF2AK3	0.68159563
50	PAK1	0.66592876
51	PDK2	0.65321641
52	STK4	0.64996896
53	STK3	0.64182448
54	STK38L	0.63509593
55	CSNK2A1	0.63001515
56	CSNK1E	0.62324108
57	RAF1	0.60763179
58	PIM1	0.60108634
59	PINK1	0.58965053
60	GRK5	0.57253723
61	NEK2	0.54647630
62	PRKD1	0.53818803
63	ARAF	0.53088681
64	CSNK2A2	0.50881632
65	WNK4	0.50326617
66	CDK2	0.50133909
67	ATR	0.49873641
68	MAPKAPK2	0.49637533
69	CAMK4	0.49326186
70	AKT2	0.47644909
71	GRK7	0.47561552
72	PIK3CA	0.45312680
73	CDK9	0.45096870
74	ILK	0.44553757
75	MAP3K5	0.43598963
76	SGK2	0.42340026
77	PRKACB	0.42169554
78	ATM	0.41218444
79	CDK1	0.41063081
80	MARK2	0.40555705
81	GSK3A	0.40495917
82	PIK3CG	0.38999474
83	OBSCN	0.38860535
84	PRKG1	0.37605070
85	MAPK13	0.36271934
86	GRK1	0.36198384
87	NME1	0.35505238
88	PRKACA	0.35387952
89	BRAF	0.35304486
90	PRKCI	0.35273877
91	STK24	0.34480631
92	LIMK1	0.33919746
93	LRRK2	0.33511283
94	JAK3	0.30715739
95	RPS6KA1	0.30489625
96	MAPK11	0.28197780
97	DYRK3	0.26706254
98	ERBB4	0.26079012
99	MTOR	0.25687093
100	KDR	0.25432226

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	5.58840664
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	4.64578564
3	Ribosome_Homo sapiens_hsa03010	4.62578678
4	Basal transcription factors_Homo sapiens_hsa03022	3.53296544
5	RNA polymerase_Homo sapiens_hsa03020	3.19611450
6	Regulation of autophagy_Homo sapiens_hsa04140	2.97092955
7	mRNA surveillance pathway_Homo sapiens_hsa03015	2.64104366
8	RNA transport_Homo sapiens_hsa03013	2.53214726
9	Mismatch repair_Homo sapiens_hsa03430	2.52249221
10	Homologous recombination_Homo sapiens_hsa03440	2.47282539
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.37210895
12	Fatty acid biosynthesis_Homo sapiens_hsa00061	2.27211809
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.02735635
14	Oocyte meiosis_Homo sapiens_hsa04114	2.02364640
15	Folate biosynthesis_Homo sapiens_hsa00790	2.00689696
16	Spliceosome_Homo sapiens_hsa03040	1.97919456
17	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.95492060
18	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.86879048
19	RNA degradation_Homo sapiens_hsa03018	1.71551823
20	Cell cycle_Homo sapiens_hsa04110	1.71457558
21	Sulfur metabolism_Homo sapiens_hsa00920	1.56228346
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.52845648
23	DNA replication_Homo sapiens_hsa03030	1.47640547
24	Bile secretion_Homo sapiens_hsa04976	1.42714028
25	Olfactory transduction_Homo sapiens_hsa04740	1.36905589
26	p53 signaling pathway_Homo sapiens_hsa04115	1.32593850
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.26755085
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20530384
29	Taste transduction_Homo sapiens_hsa04742	1.14453983
30	Huntingtons disease_Homo sapiens_hsa05016	1.07608592
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.05177231
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.03855929
33	Insulin secretion_Homo sapiens_hsa04911	0.99945807
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.99834590
35	Purine metabolism_Homo sapiens_hsa00230	0.98924686
36	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.96267949
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.90949674
38	Retinol metabolism_Homo sapiens_hsa00830	0.79902583
39	Linoleic acid metabolism_Homo sapiens_hsa00591	0.76729099
40	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.73401717
41	Alcoholism_Homo sapiens_hsa05034	0.73209891
42	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.69716259
43	Phototransduction_Homo sapiens_hsa04744	0.67986214
44	Steroid biosynthesis_Homo sapiens_hsa00100	0.65750681
45	Wnt signaling pathway_Homo sapiens_hsa04310	0.64631652
46	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64227328
47	Cardiac muscle contraction_Homo sapiens_hsa04260	0.62920640
48	Herpes simplex infection_Homo sapiens_hsa05168	0.61193511
49	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.59658269
50	Tight junction_Homo sapiens_hsa04530	0.59537221
51	Viral carcinogenesis_Homo sapiens_hsa05203	0.58249108
52	Base excision repair_Homo sapiens_hsa03410	0.58216891
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57781367
54	Serotonergic synapse_Homo sapiens_hsa04726	0.56502135
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56200526
56	Protein export_Homo sapiens_hsa03060	0.55125302
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.55062870
58	Parkinsons disease_Homo sapiens_hsa05012	0.50531504
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.48528249
60	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.48418651
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.46433807
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.46229197
63	Nicotine addiction_Homo sapiens_hsa05033	0.43868607
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43811709
65	GABAergic synapse_Homo sapiens_hsa04727	0.42361760
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.41681174
67	Circadian rhythm_Homo sapiens_hsa04710	0.41110619
68	Glutathione metabolism_Homo sapiens_hsa00480	0.40464113
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38289900
70	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.37819845
71	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37722713
72	Hippo signaling pathway_Homo sapiens_hsa04390	0.36422122
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.36256352
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.34742929
75	Fatty acid elongation_Homo sapiens_hsa00062	0.30353089
76	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.29983732
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29780604
78	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29048903
79	Calcium signaling pathway_Homo sapiens_hsa04020	0.27740372
80	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.27133185
81	Cholinergic synapse_Homo sapiens_hsa04725	0.25666366
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.25269385
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.20698571
84	Morphine addiction_Homo sapiens_hsa05032	0.20698087
85	Proteasome_Homo sapiens_hsa03050	0.19990729
86	Cocaine addiction_Homo sapiens_hsa05030	0.19940597
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.19686763
88	MicroRNAs in cancer_Homo sapiens_hsa05206	0.18941363
89	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.18666081
90	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.17572554
91	Basal cell carcinoma_Homo sapiens_hsa05217	0.16525413
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.16363595
93	Metabolic pathways_Homo sapiens_hsa01100	0.15761674
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.15299997
95	Amphetamine addiction_Homo sapiens_hsa05031	0.14966312
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.14296230
97	Apoptosis_Homo sapiens_hsa04210	0.14096420
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.13502853
99	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.12872373
100	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.12577244

C1DP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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