C1GALT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesoderm development (GO:2000380)4.37667592
2L-phenylalanine catabolic process (GO:0006559)4.13957270
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13957270
4Golgi transport vesicle coating (GO:0048200)4.03610760
5COPI coating of Golgi vesicle (GO:0048205)4.03610760
6alpha-linolenic acid metabolic process (GO:0036109)3.92761959
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.92678489
8L-phenylalanine metabolic process (GO:0006558)3.92678489
9sequestering of extracellular ligand from receptor (GO:0035581)3.92619470
10mitotic G2 DNA damage checkpoint (GO:0007095)3.90171009
11somite rostral/caudal axis specification (GO:0032525)3.89415886
12mitotic G2/M transition checkpoint (GO:0044818)3.89391835
13CENP-A containing nucleosome assembly (GO:0034080)3.86420659
14female gonad development (GO:0008585)3.83043102
15sulfur amino acid catabolic process (GO:0000098)3.81496885
16anterior/posterior axis specification, embryo (GO:0008595)3.81394466
17cell migration involved in gastrulation (GO:0042074)3.80494388
18cysteine metabolic process (GO:0006534)3.78947072
19regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.76510505
20aromatic amino acid family catabolic process (GO:0009074)3.68259260
21chromatin remodeling at centromere (GO:0031055)3.67802182
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.66176804
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.66176804
24lysine metabolic process (GO:0006553)3.64083045
25lysine catabolic process (GO:0006554)3.64083045
26nucleotide-sugar biosynthetic process (GO:0009226)3.62183586
27phospholipid scrambling (GO:0017121)3.60119853
28nodal signaling pathway (GO:0038092)3.59569285
29anterior/posterior axis specification (GO:0009948)3.58145048
30regulation of gamma-delta T cell differentiation (GO:0045586)3.56243480
31negative regulation of activin receptor signaling pathway (GO:0032926)3.56056878
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52997969
33positive regulation of gamma-delta T cell activation (GO:0046645)3.46379507
34negative regulation of fibrinolysis (GO:0051918)3.44593966
35regulation of cholesterol homeostasis (GO:2000188)3.43608954
36histone exchange (GO:0043486)3.39370417
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.39186721
38urea cycle (GO:0000050)3.37455463
39urea metabolic process (GO:0019627)3.37455463
40DNA double-strand break processing (GO:0000729)3.37185328
41positive regulation of SMAD protein import into nucleus (GO:0060391)3.35966349
42complement activation, alternative pathway (GO:0006957)3.35705153
43histone mRNA catabolic process (GO:0071044)3.34900030
44kynurenine metabolic process (GO:0070189)3.34860342
45positive regulation of histone deacetylation (GO:0031065)3.34285665
46valine metabolic process (GO:0006573)3.33790242
47positive regulation of protein autophosphorylation (GO:0031954)3.29645363
48protein carboxylation (GO:0018214)3.29598981
49peptidyl-glutamic acid carboxylation (GO:0017187)3.29598981
50homocysteine metabolic process (GO:0050667)3.28645698
51signal transduction involved in regulation of gene expression (GO:0023019)3.28267751
52very-low-density lipoprotein particle assembly (GO:0034379)3.27942194
53indole-containing compound catabolic process (GO:0042436)3.27857138
54indolalkylamine catabolic process (GO:0046218)3.27857138
55tryptophan catabolic process (GO:0006569)3.27857138
56dorsal/ventral axis specification (GO:0009950)3.25988771
57regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.25438021
58phospholipid homeostasis (GO:0055091)3.25105412
59tryptophan metabolic process (GO:0006568)3.24084783
60antigen processing and presentation of endogenous antigen (GO:0019883)3.23000795
61primitive streak formation (GO:0090009)3.20153451
62UDP-N-acetylglucosamine metabolic process (GO:0006047)3.19573553
63hepatocyte apoptotic process (GO:0097284)3.17090140
64gastrulation (GO:0007369)3.16051299
65drug transmembrane transport (GO:0006855)3.14997733
66regulation of protein activation cascade (GO:2000257)3.12933391
67COPII vesicle coating (GO:0048208)3.12584714
68glyoxylate metabolic process (GO:0046487)3.12173240
69regulation of gamma-delta T cell activation (GO:0046643)3.06524064
70nucleotide-sugar metabolic process (GO:0009225)3.03783644
71bile acid biosynthetic process (GO:0006699)3.03257335
72regulation of metalloenzyme activity (GO:0048552)3.03090224
73negative regulation of cell fate specification (GO:0009996)3.02791658
74DNA replication-independent nucleosome assembly (GO:0006336)3.02308868
75DNA replication-independent nucleosome organization (GO:0034724)3.02308868
76positive regulation of glycoprotein biosynthetic process (GO:0010560)3.01183018
77regulation of fibrinolysis (GO:0051917)3.01014421
78proteasome assembly (GO:0043248)3.00430226
79protein neddylation (GO:0045116)2.98912103
80regulation of complement activation (GO:0030449)2.98760886
81negative regulation of thymocyte apoptotic process (GO:0070244)2.98544172
82bile acid and bile salt transport (GO:0015721)2.97945182
83negative regulation of DNA-dependent DNA replication (GO:2000104)2.97888048
84regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97869527
85regulation of triglyceride catabolic process (GO:0010896)2.97834087
86regulation of acyl-CoA biosynthetic process (GO:0050812)2.96976416
87nitrogen cycle metabolic process (GO:0071941)2.96871190
88mesodermal cell differentiation (GO:0048333)2.96621249
89positive regulation of fatty acid beta-oxidation (GO:0032000)2.96329010
90nuclear pore complex assembly (GO:0051292)2.95527626
91activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95334210
92bile acid metabolic process (GO:0008206)2.95279356
93intestinal cholesterol absorption (GO:0030299)2.95022336
94regulation of cell fate specification (GO:0042659)2.94773825
95mitotic sister chromatid cohesion (GO:0007064)2.94626894
96regulation of fatty acid beta-oxidation (GO:0031998)2.92990152
97high-density lipoprotein particle remodeling (GO:0034375)2.92214828
98negative regulation of cholesterol transport (GO:0032375)2.90846277
99negative regulation of sterol transport (GO:0032372)2.90846277
100positive regulation of nuclease activity (GO:0032075)2.89973874
101regulation of sulfur metabolic process (GO:0042762)2.89670700
102somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.89599041
103isotype switching (GO:0045190)2.89599041
104somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.89599041
105response to X-ray (GO:0010165)2.89360511
106ethanol oxidation (GO:0006069)2.88896270
1074-hydroxyproline metabolic process (GO:0019471)2.87693354
108intestinal absorption (GO:0050892)2.87137799
109negative regulation of protein activation cascade (GO:2000258)2.86481379
110phospholipid efflux (GO:0033700)2.84892505
111reverse cholesterol transport (GO:0043691)2.83482940
112regulation of gene silencing by RNA (GO:0060966)2.82697623
113regulation of posttranscriptional gene silencing (GO:0060147)2.82697623
114regulation of gene silencing by miRNA (GO:0060964)2.82697623
115regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.81887603
116regulation of coenzyme metabolic process (GO:0051196)2.81662153
117regulation of cofactor metabolic process (GO:0051193)2.81662153
118maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.80737386
119resolution of meiotic recombination intermediates (GO:0000712)2.79941378
120nuclear pore organization (GO:0006999)2.79004948
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.78621335
122kidney morphogenesis (GO:0060993)2.74892226
123cellular glucuronidation (GO:0052695)2.74411782
124negative regulation of complement activation (GO:0045916)2.73807569
125lipoprotein metabolic process (GO:0042157)2.73161978
126regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72718322
127DNA replication-dependent nucleosome assembly (GO:0006335)2.72314110
128DNA replication-dependent nucleosome organization (GO:0034723)2.72314110
129plasma lipoprotein particle assembly (GO:0034377)2.72305502
130prenylation (GO:0097354)2.72100055
131protein prenylation (GO:0018342)2.72100055
132protein-lipid complex assembly (GO:0065005)2.72027219
133synapsis (GO:0007129)2.71297388
134regulation of helicase activity (GO:0051095)2.71242017
135tricarboxylic acid metabolic process (GO:0072350)2.71163637
136positive regulation of glycolytic process (GO:0045821)2.71138995
137RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.70099906
1382-oxoglutarate metabolic process (GO:0006103)2.69755235
139regulation of Golgi to plasma membrane protein transport (GO:0042996)2.69204725
140positive regulation of B cell differentiation (GO:0045579)2.67240402
141regulation of nuclease activity (GO:0032069)2.66314170
142plasma lipoprotein particle clearance (GO:0034381)2.66013629
143amino-acid betaine metabolic process (GO:0006577)2.65942348
144tyrosine metabolic process (GO:0006570)2.65813505
145embryonic axis specification (GO:0000578)2.65153121
146growth hormone receptor signaling pathway (GO:0060396)2.65125186
147double-strand break repair via nonhomologous end joining (GO:0006303)2.64648555
148non-recombinational repair (GO:0000726)2.64648555
149endoplasmic reticulum unfolded protein response (GO:0030968)2.63886367
150DNA ligation (GO:0006266)2.63567766
151regulation of superoxide anion generation (GO:0032928)2.62979834
152triglyceride homeostasis (GO:0070328)2.62673761
153acylglycerol homeostasis (GO:0055090)2.62673761
154regulation of DNA endoreduplication (GO:0032875)2.61208249
155protein localization to kinetochore (GO:0034501)2.61063367
156regulation of apoptotic cell clearance (GO:2000425)2.60546785
157serine family amino acid catabolic process (GO:0009071)2.59999861
158cellular modified amino acid catabolic process (GO:0042219)2.59719290
159urate metabolic process (GO:0046415)2.58585277
160substrate adhesion-dependent cell spreading (GO:0034446)2.57969505
161positive regulation of lipid catabolic process (GO:0050996)2.57955588
162low-density lipoprotein particle remodeling (GO:0034374)2.56198580
163hormone catabolic process (GO:0042447)2.56094154
164regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55890259
165regulation of mitotic spindle checkpoint (GO:1903504)2.55890259
166aromatic amino acid family metabolic process (GO:0009072)2.55239613
167epoxygenase P450 pathway (GO:0019373)2.54822779
168pre-miRNA processing (GO:0031054)2.54333670
169pathway-restricted SMAD protein phosphorylation (GO:0060389)2.54044004
170positive regulation of glycoprotein metabolic process (GO:1903020)2.53276493
171regulation of centriole replication (GO:0046599)2.52699972
172embryonic foregut morphogenesis (GO:0048617)2.52415260
173regulation of sister chromatid cohesion (GO:0007063)2.52331132
174negative regulation of DNA recombination (GO:0045910)2.51443336
175cellular response to unfolded protein (GO:0034620)2.51423584
176fatty acid oxidation (GO:0019395)2.50940807
177complement activation, classical pathway (GO:0006958)2.49356204
178ER-nucleus signaling pathway (GO:0006984)2.49302869
179fatty acid beta-oxidation (GO:0006635)2.48755989
180sequestering of metal ion (GO:0051238)2.47889853
181protein-lipid complex remodeling (GO:0034368)2.47136666
182macromolecular complex remodeling (GO:0034367)2.47136666
183plasma lipoprotein particle remodeling (GO:0034369)2.47136666
184low-density lipoprotein particle clearance (GO:0034383)2.46664980
185regulation of cell fate commitment (GO:0010453)2.46339585
186histone mRNA metabolic process (GO:0008334)2.46324408
187regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.45700622
188antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.45237870
189regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45018192
190regulation of mitotic metaphase/anaphase transition (GO:0030071)2.45018192
191ribosome assembly (GO:0042255)2.44524758
192erythrocyte maturation (GO:0043249)2.44362695
193lipid oxidation (GO:0034440)2.43996440
194regulation of chromatin silencing (GO:0031935)2.43729358
195regulation of SMAD protein import into nucleus (GO:0060390)2.43468851
196mitochondrial DNA replication (GO:0006264)2.43362591

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.42289214
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.63326605
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.22246345
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.92817290
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.59501889
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.58265175
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.14004058
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11182603
9GATA1_22025678_ChIP-Seq_K562_Human2.92497848
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.81206329
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71502246
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.70207435
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.62934511
14CLOCK_20551151_ChIP-Seq_293T_Human2.41971647
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.40105711
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.38539166
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36842365
18ELK1_19687146_ChIP-ChIP_HELA_Human2.35596154
19MYC_22102868_ChIP-Seq_BL_Human2.31582719
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27878954
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22229672
22PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20274222
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19354024
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.16863760
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10590560
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09470001
27* EWS_26573619_Chip-Seq_HEK293_Human2.07570284
28* P300_19829295_ChIP-Seq_ESCs_Human1.90219477
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.88288776
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88211965
31* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.87078740
32FUS_26573619_Chip-Seq_HEK293_Human1.81909097
33E2F7_22180533_ChIP-Seq_HELA_Human1.80942978
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.79547009
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79178328
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74693610
37GBX2_23144817_ChIP-Seq_PC3_Human1.71923392
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71800839
39TAF15_26573619_Chip-Seq_HEK293_Human1.70884723
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70573098
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70304049
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70176963
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.66384450
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.65364869
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65141851
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.64550465
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.64316459
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63245962
49VDR_22108803_ChIP-Seq_LS180_Human1.63212375
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.63097163
51IGF1R_20145208_ChIP-Seq_DFB_Human1.61404665
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60372192
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59779201
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59385627
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59040119
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59000523
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55425685
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52479770
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52003244
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50306900
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.49704183
62MYB_26560356_Chip-Seq_TH2_Human1.49553173
63TCF7_22412390_ChIP-Seq_EML_Mouse1.49405069
64MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49031534
65MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47875473
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.47357183
67RUNX_20019798_ChIP-Seq_JUKART_Human1.46687352
68VDR_21846776_ChIP-Seq_THP-1_Human1.46606783
69* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45738662
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.45453141
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.45401456
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45337656
73GATA6_25053715_ChIP-Seq_YYC3_Human1.45176588
74RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43437022
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43409569
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.42612291
77MAF_26560356_Chip-Seq_TH1_Human1.42415486
78MYB_26560356_Chip-Seq_TH1_Human1.41807498
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41732081
80IRF8_27001747_Chip-Seq_BMDM_Mouse1.41179069
81* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40909099
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40598453
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40482492
84* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40208032
85* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39755045
86ZNF274_21170338_ChIP-Seq_K562_Hela1.39259619
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38039755
88UTX_26944678_Chip-Seq_JUKART_Human1.37627364
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.37115094
90GATA4_25053715_ChIP-Seq_YYC3_Human1.36402398
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.36337613
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36082501
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.35184628
94ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33261189
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32773220
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32235692
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31614260
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31230663
99* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30897712
100* CDX2_22108803_ChIP-Seq_LS180_Human1.30810450
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29987352
102Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29232933
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28748789
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28012709
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.26041399
106ESR1_21235772_ChIP-Seq_MCF-7_Human1.25422273
107GABP_17652178_ChIP-ChIP_JURKAT_Human1.24978073
108* BRD4_25478319_ChIP-Seq_HGPS_Human1.24821409
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24222842
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22838090
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22462789
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22459548
113* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21570113
114* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21570113
115TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19765751
116* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19675023
117* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17225507
118BCAT_22108803_ChIP-Seq_LS180_Human1.17179887
119SCL_19346495_ChIP-Seq_HPC-7_Human1.17037678
120* GATA1_19941826_ChIP-Seq_K562_Human1.16385819
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.15672783
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15230672
123VDR_24763502_ChIP-Seq_THP-1_Human1.15049741
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.14768255
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13860461
126POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13293760
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.12644849
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11730218
129ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11551019
130* SOX2_19829295_ChIP-Seq_ESCs_Human1.11475703
131* NANOG_19829295_ChIP-Seq_ESCs_Human1.11475703
132AR_21909140_ChIP-Seq_LNCAP_Human1.11251217
133GATA3_27048872_Chip-Seq_THYMUS_Human1.10666161
134EP300_21415370_ChIP-Seq_HL-1_Mouse1.10396834
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10305604
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.10182091
137HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09719078
138* STAT3_23295773_ChIP-Seq_U87_Human1.09537114
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07177048
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07077360
141CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07007798
142GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06856093
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06183254
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.05974868
145RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05636695
146CDX2_20551321_ChIP-Seq_CACO-2_Human1.05631709
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05398492
148ER_23166858_ChIP-Seq_MCF-7_Human1.05359528
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04952726
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04952726
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04952726
152SMAD4_21799915_ChIP-Seq_A2780_Human1.04665448
153* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04551105
154CMYC_18555785_Chip-Seq_ESCs_Mouse1.04195924
155OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04130060
156KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.02827441
157SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02394724
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02084238
159SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01908734
160* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00044450
161* GATA2_19941826_ChIP-Seq_K562_Human0.99977279
162P53_22387025_ChIP-Seq_ESCs_Mouse0.99091122
163SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98995189
164ZNF263_19887448_ChIP-Seq_K562_Human0.98680861
165KDM2B_26808549_Chip-Seq_DND41_Human0.98630914
166* CJUN_26792858_Chip-Seq_BT549_Human0.98566547
167RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98340863
168E2F1_18555785_Chip-Seq_ESCs_Mouse0.97997659
169FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97766228
170EOMES_21245162_ChIP-Seq_HESCs_Human0.97688222
171SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97547917
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97547917
173NCOR1_26117541_ChIP-Seq_K562_Human0.97427675
174CHD1_26751641_Chip-Seq_LNCaP_Human0.97125358
175AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96597236
176ELK3_25401928_ChIP-Seq_HUVEC_Human0.95753101
177* HNF4A_19822575_ChIP-Seq_HepG2_Human0.95618580
178FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95588814
179TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95547588
180SOX2_20726797_ChIP-Seq_SW620_Human0.94710573
181FOXA1_25552417_ChIP-Seq_VCAP_Human0.94094865
182GATA2_21666600_ChIP-Seq_HMVEC_Human0.92238907
183HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91894966
184ATF3_27146783_Chip-Seq_COLON_Human0.91734486
185RUNX1_22412390_ChIP-Seq_EML_Mouse0.91026749
186FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90756838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry5.22896414
2MP0002139_abnormal_hepatobiliary_system4.62860306
3* MP0006054_spinal_hemorrhage4.38076775
4MP0005360_urolithiasis4.10967510
5MP0005365_abnormal_bile_salt3.59039789
6MP0005085_abnormal_gallbladder_physiolo3.42894488
7MP0003300_gastrointestinal_ulcer3.11097224
8MP0003950_abnormal_plasma_membrane3.10542410
9MP0008057_abnormal_DNA_replication2.94517076
10MP0003252_abnormal_bile_duct2.91185894
11MP0010234_abnormal_vibrissa_follicle2.85572314
12MP0009697_abnormal_copulation2.78774710
13MP0003941_abnormal_skin_development2.64542885
14MP0008875_abnormal_xenobiotic_pharmacok2.48653013
15MP0003122_maternal_imprinting2.46553039
16MP0001666_abnormal_nutrient_absorption2.31805727
17MP0003705_abnormal_hypodermis_morpholog2.29087596
18MP0004957_abnormal_blastocyst_morpholog2.19145951
19MP0002138_abnormal_hepatobiliary_system2.17286256
20MP0008877_abnormal_DNA_methylation2.15365260
21MP0004272_abnormal_basement_membrane2.09899982
22MP0010329_abnormal_lipoprotein_level2.01188039
23MP0002166_altered_tumor_susceptibility1.99560011
24MP0010352_gastrointestinal_tract_polyps1.95783885
25MP0003195_calcinosis1.88356409
26MP0002877_abnormal_melanocyte_morpholog1.86144418
27MP0008058_abnormal_DNA_repair1.85746921
28MP0010094_abnormal_chromosome_stability1.84100836
29* MP0001915_intracranial_hemorrhage1.80892017
30MP0004147_increased_porphyrin_level1.78051673
31MP0003567_abnormal_fetal_cardiomyocyte1.75459936
32MP0000569_abnormal_digit_pigmentation1.73793954
33MP0005083_abnormal_biliary_tract1.72896831
34MP0003806_abnormal_nucleotide_metabolis1.72208550
35MP0000609_abnormal_liver_physiology1.71615040
36MP0003718_maternal_effect1.69522401
37MP0005084_abnormal_gallbladder_morpholo1.68349299
38MP0002396_abnormal_hematopoietic_system1.68294325
39MP0003868_abnormal_feces_composition1.62530750
40MP0003191_abnormal_cellular_cholesterol1.61330664
41MP0003121_genomic_imprinting1.54393864
42MP0009840_abnormal_foam_cell1.53934927
43MP0004264_abnormal_extraembryonic_tissu1.53036937
44* MP0009643_abnormal_urine_homeostasis1.43018928
45MP0000516_abnormal_urinary_system1.42777834
46MP0005367_renal/urinary_system_phenotyp1.42777834
47MP0004947_skin_inflammation1.40903091
48MP0005076_abnormal_cell_differentiation1.39270875
49MP0008007_abnormal_cellular_replicative1.38546645
50MP0005380_embryogenesis_phenotype1.38534156
51MP0001672_abnormal_embryogenesis/_devel1.38534156
52MP0003303_peritoneal_inflammation1.38385772
53MP0008932_abnormal_embryonic_tissue1.36421495
54MP0002084_abnormal_developmental_patter1.33023886
55MP0000685_abnormal_immune_system1.33001513
56MP0005220_abnormal_exocrine_pancreas1.31955471
57MP0003937_abnormal_limbs/digits/tail_de1.31560166
58* MP0005332_abnormal_amino_acid1.31459754
59MP0010155_abnormal_intestine_physiology1.29214875
60MP0005387_immune_system_phenotype1.27163900
61MP0001790_abnormal_immune_system1.27163900
62MP0003119_abnormal_digestive_system1.26493475
63MP0002006_tumorigenesis1.25963256
64MP0003436_decreased_susceptibility_to1.25232886
65MP0001800_abnormal_humoral_immune1.25203802
66MP0002086_abnormal_extraembryonic_tissu1.23861301
67MP0002118_abnormal_lipid_homeostasis1.23288075
68MP0001730_embryonic_growth_arrest1.22385378
69MP0003984_embryonic_growth_retardation1.19795462
70MP0003566_abnormal_cell_adhesion1.18133643
71MP0002088_abnormal_embryonic_growth/wei1.17848355
72MP0001697_abnormal_embryo_size1.17770829
73MP0003111_abnormal_nucleus_morphology1.17143269
74MP0001879_abnormal_lymphatic_vessel1.16537025
75MP0003786_premature_aging1.15963890
76MP0003656_abnormal_erythrocyte_physiolo1.14982330
77MP0005319_abnormal_enzyme/_coenzyme1.13365404
78MP0003943_abnormal_hepatobiliary_system1.09863772
79MP0001944_abnormal_pancreas_morphology1.08681528
80MP0005395_other_phenotype1.07884864
81MP0000598_abnormal_liver_morphology1.07538759
82MP0001293_anophthalmia1.07360203
83MP0002928_abnormal_bile_duct1.05933861
84MP0001286_abnormal_eye_development1.05802555
85MP0001873_stomach_inflammation1.04811827
86MP0001835_abnormal_antigen_presentation1.04073872
87MP0004185_abnormal_adipocyte_glucose1.03980917
88MP0002060_abnormal_skin_morphology1.02672716
89MP0000013_abnormal_adipose_tissue1.01520978
90MP0003077_abnormal_cell_cycle1.01256410
91MP0001485_abnormal_pinna_reflex0.98389769
92* MP0002136_abnormal_kidney_physiology0.97409265
93MP0004019_abnormal_vitamin_homeostasis0.97154242
94MP0005464_abnormal_platelet_physiology0.96944832
95MP0005636_abnormal_mineral_homeostasis0.96903701
96MP0005174_abnormal_tail_pigmentation0.95711483
97MP0008004_abnormal_stomach_pH0.95055021
98MP0003453_abnormal_keratinocyte_physiol0.94893213
99MP0002938_white_spotting0.94718617
100MP0005623_abnormal_meninges_morphology0.94523919
101MP0004043_abnormal_pH_regulation0.94511310
102MP0002693_abnormal_pancreas_physiology0.93565490
103MP0002452_abnormal_antigen_presenting0.93309091
104MP0002078_abnormal_glucose_homeostasis0.92555175
105MP0003183_abnormal_peptide_metabolism0.92496545
106MP0003866_abnormal_defecation0.92155792
107* MP0001845_abnormal_inflammatory_respons0.91384762
108MP0001756_abnormal_urination0.91214746
109MP0002009_preneoplasia0.90846611
110MP0010678_abnormal_skin_adnexa0.90263666
111MP0005023_abnormal_wound_healing0.87859646
112MP0005408_hypopigmentation0.87829289
113MP0000003_abnormal_adipose_tissue0.86991206
114MP0005584_abnormal_enzyme/coenzyme_acti0.86873002
115MP0004130_abnormal_muscle_cell0.86695526
116MP0008438_abnormal_cutaneous_collagen0.85892786
117MP0005666_abnormal_adipose_tissue0.85856473
118MP0001765_abnormal_ion_homeostasis0.85705384
119MP0004808_abnormal_hematopoietic_stem0.85413118
120MP0009780_abnormal_chondrocyte_physiolo0.85117208
121MP0009278_abnormal_bone_marrow0.85106071
122MP0002085_abnormal_embryonic_tissue0.84598150
123MP0010368_abnormal_lymphatic_system0.84383901
124MP0008469_abnormal_protein_level0.84023531
125MP0000428_abnormal_craniofacial_morphol0.83792539
126MP0002254_reproductive_system_inflammat0.83056041
127MP0005275_abnormal_skin_tensile0.82789163
128MP0005075_abnormal_melanosome_morpholog0.80931139
129MP0008961_abnormal_basal_metabolism0.80638579
130MP0005375_adipose_tissue_phenotype0.80092868
131MP0005058_abnormal_lysosome_morphology0.79395188
132MP0009384_cardiac_valve_regurgitation0.78825910
133MP0002896_abnormal_bone_mineralization0.78361881
134MP0004215_abnormal_myocardial_fiber0.78214881
135MP0000689_abnormal_spleen_morphology0.78175255
136* MP0002398_abnormal_bone_marrow0.77607259
137MP0002723_abnormal_immune_serum0.77232529
138MP0000358_abnormal_cell_content/0.76720583
139MP0003385_abnormal_body_wall0.76108822
140MP0000465_gastrointestinal_hemorrhage0.74507119
141MP0002420_abnormal_adaptive_immunity0.74480237
142MP0005000_abnormal_immune_tolerance0.74217490
143MP0003045_fibrosis0.74209611
144MP0002111_abnormal_tail_morphology0.74163352
145MP0000767_abnormal_smooth_muscle0.74109664
146MP0003186_abnormal_redox_activity0.73522204
147MP0000350_abnormal_cell_proliferation0.73481027
148MP0001819_abnormal_immune_cell0.72811132
149MP0010307_abnormal_tumor_latency0.72686535
150MP0002722_abnormal_immune_system0.72265569
151MP0009703_decreased_birth_body0.71890317
152MP0008260_abnormal_autophagy0.71745751
153MP0000477_abnormal_intestine_morphology0.71631696
154MP0000716_abnormal_immune_system0.70559054
155MP0005334_abnormal_fat_pad0.70168204
156MP0002168_other_aberrant_phenotype0.69736072
157MP0001661_extended_life_span0.69520553
158MP0002909_abnormal_adrenal_gland0.69446503
159MP0009763_increased_sensitivity_to0.69390221
160* MP0002080_prenatal_lethality0.69127667
161MP0003172_abnormal_lysosome_physiology0.68560724
162* MP0002925_abnormal_cardiovascular_devel0.67960572
163MP0004133_heterotaxia0.67735106
164MP0002233_abnormal_nose_morphology0.67489313
165MP0005384_cellular_phenotype0.66501038
166MP0000432_abnormal_head_morphology0.62902110
167MP0000427_abnormal_hair_cycle0.62686671
168* MP0001119_abnormal_female_reproductive0.61511717
169MP0002163_abnormal_gland_morphology0.60536318

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.25608658
2Intrahepatic cholestasis (HP:0001406)4.14489897
3Hypoglycemic coma (HP:0001325)3.77155637
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.69947496
5Xanthomatosis (HP:0000991)3.59600394
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52996412
7Abnormality of the common coagulation pathway (HP:0010990)3.31629170
8Biliary tract neoplasm (HP:0100574)3.24792322
9Abnormality of chromosome stability (HP:0003220)3.19096170
10Verrucae (HP:0200043)3.11897057
11Papilloma (HP:0012740)3.11897057
12Cardiovascular calcification (HP:0011915)3.04695476
13Small epiphyses (HP:0010585)3.03136975
14Vascular calcification (HP:0004934)2.97593400
15Hypobetalipoproteinemia (HP:0003563)2.96785296
16Hypoplasia of the thymus (HP:0000778)2.94716964
17Hypoglycemic seizures (HP:0002173)2.93841374
18Mitral stenosis (HP:0001718)2.93604156
19Papillary thyroid carcinoma (HP:0002895)2.93464778
20Meckel diverticulum (HP:0002245)2.92009611
21Abnormality of the intrinsic pathway (HP:0010989)2.92008298
22Complement deficiency (HP:0004431)2.83438343
23Hyperinsulinemic hypoglycemia (HP:0000825)2.82254772
24Myocardial infarction (HP:0001658)2.79391878
25Abnormality of oral frenula (HP:0000190)2.79108267
26Abnormal auditory evoked potentials (HP:0006958)2.76436697
27Chromsome breakage (HP:0040012)2.75264846
28Conjugated hyperbilirubinemia (HP:0002908)2.75069561
29B lymphocytopenia (HP:0010976)2.73593910
30Abnormality of B cell number (HP:0010975)2.73593910
31Abnormality of the ileum (HP:0001549)2.73172187
32Methylmalonic acidemia (HP:0002912)2.72244462
33Ketosis (HP:0001946)2.70226225
34Ketoacidosis (HP:0001993)2.70162419
35Embryonal renal neoplasm (HP:0011794)2.69624979
36T lymphocytopenia (HP:0005403)2.69506603
37Bifid tongue (HP:0010297)2.67527063
38Supernumerary spleens (HP:0009799)2.65993661
39Recurrent viral infections (HP:0004429)2.64760091
40Epidermoid cyst (HP:0200040)2.64372465
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63394302
42Gonadal dysgenesis (HP:0000133)2.62528249
43Agammaglobulinemia (HP:0004432)2.62235732
44Abnormality of endocrine pancreas physiology (HP:0012093)2.61843871
45Abnormality of the pancreatic islet cells (HP:0006476)2.61843871
46Poikilocytosis (HP:0004447)2.61603747
47Abnormality of T cell number (HP:0011839)2.57927882
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.57450830
49Abnormal biliary tract morphology (HP:0012440)2.57250921
50Disproportionate short-trunk short stature (HP:0003521)2.57137956
51Fat malabsorption (HP:0002630)2.55251873
52Cellulitis (HP:0100658)2.52141079
53Abnormality of purine metabolism (HP:0004352)2.51129331
54Prolonged partial thromboplastin time (HP:0003645)2.49278629
55Neoplasm of the small intestine (HP:0100833)2.46847462
56Hepatocellular carcinoma (HP:0001402)2.44961583
57Acanthocytosis (HP:0001927)2.44563013
58Hyperlipoproteinemia (HP:0010980)2.43389851
59Ankyloglossia (HP:0010296)2.43020386
60Hypolipoproteinemia (HP:0010981)2.42882496
61Colitis (HP:0002583)2.39868947
62Nephroblastoma (Wilms tumor) (HP:0002667)2.39123846
63Thyroid carcinoma (HP:0002890)2.38291007
64Abnormality of vitamin B metabolism (HP:0004340)2.35894823
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.33799746
66Subacute progressive viral hepatitis (HP:0006572)2.32648285
67Thyroiditis (HP:0100646)2.31625727
68Hyperglycemia (HP:0003074)2.31321381
69Esophageal varix (HP:0002040)2.30860963
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29505337
71Joint hemorrhage (HP:0005261)2.28728472
72Symptomatic seizures (HP:0011145)2.27297546
73Hypoalphalipoproteinemia (HP:0003233)2.25428560
74Gout (HP:0001997)2.23613465
75Abnormality of sulfur amino acid metabolism (HP:0004339)2.21326429
76Late onset (HP:0003584)2.19109204
77Abnormal foot bone ossification (HP:0010675)2.19047247
78Anal stenosis (HP:0002025)2.18922242
79Ulnar bowing (HP:0003031)2.16192979
80Volvulus (HP:0002580)2.15108298
81Hematochezia (HP:0002573)2.14796953
82Pancreatic islet-cell hyperplasia (HP:0004510)2.14795962
83Ovarian neoplasm (HP:0100615)2.14425087
84Epiphyseal dysplasia (HP:0002656)2.14275206
85Recurrent bronchitis (HP:0002837)2.14040555
86Neoplasm of the rectum (HP:0100743)2.13047419
87Abnormal lung lobation (HP:0002101)2.13027405
88Hypophosphatemic rickets (HP:0004912)2.12499869
89Aortic aneurysm (HP:0004942)2.11783178
90Abnormality of the preputium (HP:0100587)2.10724852
91Malignant gastrointestinal tract tumors (HP:0006749)2.09455492
92Gastrointestinal carcinoma (HP:0002672)2.09455492
93Skin nodule (HP:0200036)2.08926821
94Spastic diplegia (HP:0001264)2.08864338
95Hyperammonemia (HP:0001987)2.08828076
96Irregular epiphyses (HP:0010582)2.08806102
97Rectal fistula (HP:0100590)2.07869551
98Rectovaginal fistula (HP:0000143)2.07869551
99Abnormality of complement system (HP:0005339)2.06557179
100Facial diplegia (HP:0001349)2.06523857
101Macroorchidism (HP:0000053)2.06178099
102Inflammation of the large intestine (HP:0002037)2.05201606
103Gastrointestinal inflammation (HP:0004386)2.04914250
104Increased mean platelet volume (HP:0011877)2.04750718
105Renal cortical cysts (HP:0000803)2.04537519
106Abnormality of the vitamin B12 metabolism (HP:0004341)2.03035352
107Colon cancer (HP:0003003)2.02379292
108Bilateral microphthalmos (HP:0007633)2.01357984
109Abnormality of nucleobase metabolism (HP:0010932)2.01217664
110Abnormal platelet volume (HP:0011876)2.01177340
111Intestinal atresia (HP:0011100)2.00690505
112Back pain (HP:0003418)2.00660270
113Hyperbilirubinemia (HP:0002904)1.99838532
114Uterine neoplasm (HP:0010784)1.98269126
115Rhabdomyosarcoma (HP:0002859)1.96798814
116Abnormality of methionine metabolism (HP:0010901)1.96226321
117Progressive inability to walk (HP:0002505)1.95731623
118Myelomeningocele (HP:0002475)1.94019701
119Abdominal distention (HP:0003270)1.92882649
120Abnormal cartilage morphology (HP:0002763)1.92042730
121Osteomyelitis (HP:0002754)1.91423811
122Hypochromic microcytic anemia (HP:0004840)1.91073716
123Urinary glycosaminoglycan excretion (HP:0003541)1.90182014
124Mucopolysacchariduria (HP:0008155)1.90182014
125Hypercholesterolemia (HP:0003124)1.89591846
126Hyperglycinemia (HP:0002154)1.89375773
127Gingival bleeding (HP:0000225)1.88429124
128Spontaneous abortion (HP:0005268)1.86547871
129Autoimmune thrombocytopenia (HP:0001973)1.85211149
130Short tibia (HP:0005736)1.84933943
131Abnormality of vitamin metabolism (HP:0100508)1.84249424
132Short humerus (HP:0005792)1.83884357
133Clitoromegaly (HP:0000057)1.83835575
134Increased CSF protein (HP:0002922)1.83769544
135Abnormality of the wing of the ilium (HP:0011867)1.82427717
136Aplasia/Hypoplasia of the tibia (HP:0005772)1.82398311
137Short middle phalanx of the 5th finger (HP:0004220)1.82351691
138Gonadotropin excess (HP:0000837)1.82099819
139Vaginal fistula (HP:0004320)1.81145164
140Hypothermia (HP:0002045)1.80481082
141Abnormal hand bone ossification (HP:0010660)1.79801348
142Aplasia/hypoplasia of the humerus (HP:0006507)1.78847276
143Periodontitis (HP:0000704)1.78502395
144Palpitations (HP:0001962)1.78226930
145Medulloblastoma (HP:0002885)1.77803721
146Abnormality of the duodenum (HP:0002246)1.77032388
147Prolonged bleeding time (HP:0003010)1.76920611
148Methylmalonic aciduria (HP:0012120)1.76750656
149Abnormality of T cells (HP:0002843)1.76674734
150Wide nose (HP:0000445)1.76634039
151Insulin resistance (HP:0000855)1.75632584
152Abnormality of the fingertips (HP:0001211)1.75428908
153Hyperactive renin-angiotensin system (HP:0000841)1.75288147
154Combined immunodeficiency (HP:0005387)1.75121755
155Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74043014
156Abnormal tarsal ossification (HP:0008369)1.73820669
157Micronodular cirrhosis (HP:0001413)1.73703451
158Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72340547
159Menorrhagia (HP:0000132)1.71866020
160Neoplasm of the colon (HP:0100273)1.71737935
161Panhypogammaglobulinemia (HP:0003139)1.71700660
162Polycythemia (HP:0001901)1.71479891
163Abnormality of the nasal septum (HP:0000419)1.70879904
164Abnormality of fatty-acid metabolism (HP:0004359)1.70366451
165Mitral valve prolapse (HP:0001634)1.70278249
166Rectal prolapse (HP:0002035)1.70182904
167Protuberant abdomen (HP:0001538)1.69937742
168Abnormality of proline metabolism (HP:0010907)1.69806240
169Hydroxyprolinuria (HP:0003080)1.69806240
170Right ventricular cardiomyopathy (HP:0011663)1.68717696
171Abnormality of aspartate family amino acid metabolism (HP:0010899)1.68322815
172Spontaneous hematomas (HP:0007420)1.67940087
173Aneurysm (HP:0002617)1.67651240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.81610380
2ACVR1B4.23923591
3FRK3.76468998
4ERN13.61812900
5TRIB33.31297001
6TNIK3.21307263
7PKN22.99113811
8TRIM282.83646939
9EIF2AK32.71979148
10BMPR1B2.50908108
11BRSK22.44956501
12TAF12.40485009
13MKNK22.40228683
14EIF2AK12.37482124
15SIK12.18802637
16EEF2K2.13262085
17TAOK32.12245180
18WNK32.04073772
19GRK62.02570120
20PTK62.01060380
21FGFR41.96387276
22STK391.93015759
23MAP4K11.85444288
24LRRK21.85231433
25STK101.82709723
26PLK31.78805533
27BCR1.77975460
28PLK41.76063869
29SIK31.71662546
30STK241.71015853
31FGFR31.69229233
32LATS11.69220099
33PBK1.67142503
34INSRR1.64741052
35WEE11.61796810
36SCYL21.55382631
37MKNK11.53667544
38TTK1.47388669
39MAP3K21.45711550
40STK38L1.44492468
41FGFR21.43285019
42MST41.40332268
43MST1R1.39432074
44MAP3K121.38642100
45FLT31.37401734
46CDK61.36819368
47YES11.36741429
48TYK21.34281985
49ERBB31.34188298
50FGFR11.32553431
51CDK121.30762540
52PLK21.26944999
53BCKDK1.25054881
54JAK11.24978712
55ZAK1.23611387
56STK31.22527717
57RIPK11.17299668
58ITK1.17157536
59DYRK1B1.15122532
60TGFBR21.14606362
61NEK11.14566151
62PDGFRA1.14485102
63TXK1.13295337
64PIK3CG1.13259516
65CSK1.10046018
66NEK91.09856114
67SRPK11.09153415
68TSSK61.07658988
69HIPK21.06069747
70STK41.02099173
71PASK0.98334066
72MAP3K70.98262991
73JAK20.98033014
74OXSR10.97622792
75TTN0.96802452
76JAK30.95874431
77ZAP700.95376386
78BTK0.91559165
79MAPK110.91079295
80NUAK10.89897068
81EIF2AK20.89796874
82PNCK0.87646347
83EPHB10.86440867
84CDK40.83808166
85RPS6KB20.81913737
86CSF1R0.81414002
87PDGFRB0.80148825
88MELK0.79669886
89PIM10.79662679
90PIK3CA0.78869696
91MAP3K30.78393451
92CDK90.77825171
93BRD40.77599886
94CAMK1D0.74407031
95TBK10.74003233
96SYK0.72119352
97RET0.71630400
98PLK10.71070397
99EPHA30.67726783
100MAP3K80.67627195
101TRPM70.67035750
102MET0.66819609
103EPHA20.66168457
104MAP3K140.64449798
105RPS6KA40.63216556
106TGFBR10.62378102
107FER0.62026308
108BRSK10.61094074
109MAP2K10.60407364
110MTOR0.59891815
111PTK20.59336640
112CDC70.59086014
113DMPK0.58655171
114PRKD10.58100152
115MAP2K30.57240080
116BMPR20.56562367
117NEK20.55793083
118PRKAA20.55128964
119PRKCH0.54472557
120SGK30.53872252
121EGFR0.53749280
122ADRBK10.53322016
123NLK0.52619318
124PRKCE0.52133133
125MARK30.50917314
126HCK0.47836025
127ATM0.47773475
128CAMK1G0.45887986
129LCK0.45793429
130GRK10.45050915
131PRKAA10.44129398
132BUB10.44043777
133IGF1R0.44027286
134GSK3A0.43442678
135CSNK1G10.43282371
136TEC0.43253207
137CHUK0.42785593
138ERBB40.42760502
139BMX0.42497057
140PRKCQ0.42374940
141LYN0.41542257
142DYRK30.41427079
143PDK10.39573814
144INSR0.39542266
145MAPK150.38020228
146MAP2K20.35400871
147WNK40.35025630
148MAP3K10.34330365
149PRKD20.34109436
150WNK10.33606069
151PAK40.33600592
152PAK30.33209060
153ROCK20.32720604
154IRAK10.32572696
155RAF10.31329948
156ERBB20.30855320
157MAP4K20.30543582
158KSR10.27362415
159TIE10.26942018
160KIT0.25054362
161CSNK2A10.24817036
162PRKG10.22507118

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.78234670
2Protein export_Homo sapiens_hsa030603.47203923
3Nitrogen metabolism_Homo sapiens_hsa009103.35128151
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94686051
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.94291122
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.87245595
7Mismatch repair_Homo sapiens_hsa034302.57244539
8Basal transcription factors_Homo sapiens_hsa030222.44468919
9Tryptophan metabolism_Homo sapiens_hsa003802.38921666
10Proteasome_Homo sapiens_hsa030502.36554154
11Steroid biosynthesis_Homo sapiens_hsa001002.33241026
12Sulfur metabolism_Homo sapiens_hsa009202.27348137
13Fatty acid degradation_Homo sapiens_hsa000712.20735639
14Caffeine metabolism_Homo sapiens_hsa002322.16316090
15Arginine biosynthesis_Homo sapiens_hsa002202.04065310
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03227429
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00794082
18Complement and coagulation cascades_Homo sapiens_hsa046101.99348121
19Selenocompound metabolism_Homo sapiens_hsa004501.97534581
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96341796
21Fanconi anemia pathway_Homo sapiens_hsa034601.92350324
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86374849
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83014198
24Homologous recombination_Homo sapiens_hsa034401.72581576
25TGF-beta signaling pathway_Homo sapiens_hsa043501.70022047
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64962816
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.62304900
28PPAR signaling pathway_Homo sapiens_hsa033201.62170441
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.59399812
30Nucleotide excision repair_Homo sapiens_hsa034201.58972179
31RNA degradation_Homo sapiens_hsa030181.49640663
32Lysine degradation_Homo sapiens_hsa003101.49205944
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48971889
34Cell cycle_Homo sapiens_hsa041101.41701719
35Primary immunodeficiency_Homo sapiens_hsa053401.39934045
36Bile secretion_Homo sapiens_hsa049761.37122737
37Fatty acid elongation_Homo sapiens_hsa000621.36466043
38Fat digestion and absorption_Homo sapiens_hsa049751.36298653
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35782287
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.35517493
41Histidine metabolism_Homo sapiens_hsa003401.34537314
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34438185
43Staphylococcus aureus infection_Homo sapiens_hsa051501.34433978
44ABC transporters_Homo sapiens_hsa020101.33803010
45Butanoate metabolism_Homo sapiens_hsa006501.33006822
46Propanoate metabolism_Homo sapiens_hsa006401.31981281
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31110875
48B cell receptor signaling pathway_Homo sapiens_hsa046621.30314320
49Peroxisome_Homo sapiens_hsa041461.30309674
50Fatty acid metabolism_Homo sapiens_hsa012121.30236723
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29281450
52Vitamin B6 metabolism_Homo sapiens_hsa007501.25161559
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24367629
54Starch and sucrose metabolism_Homo sapiens_hsa005001.24077257
55p53 signaling pathway_Homo sapiens_hsa041151.18261596
56Insulin resistance_Homo sapiens_hsa049311.16757627
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15565383
58RNA transport_Homo sapiens_hsa030131.14407787
59Chemical carcinogenesis_Homo sapiens_hsa052041.14127154
60Systemic lupus erythematosus_Homo sapiens_hsa053221.07063585
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06063635
62Drug metabolism - other enzymes_Homo sapiens_hsa009831.04054832
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97330723
64beta-Alanine metabolism_Homo sapiens_hsa004100.95331989
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92754617
66Phenylalanine metabolism_Homo sapiens_hsa003600.89619045
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89480941
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.88864410
69ECM-receptor interaction_Homo sapiens_hsa045120.88527894
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87049262
71Wnt signaling pathway_Homo sapiens_hsa043100.86668390
72Chronic myeloid leukemia_Homo sapiens_hsa052200.86301041
73Glutathione metabolism_Homo sapiens_hsa004800.83909512
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83649379
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.81486535
76Pyruvate metabolism_Homo sapiens_hsa006200.81470889
77Folate biosynthesis_Homo sapiens_hsa007900.80917859
78Small cell lung cancer_Homo sapiens_hsa052220.80809093
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77952071
80Hippo signaling pathway_Homo sapiens_hsa043900.77149604
81Retinol metabolism_Homo sapiens_hsa008300.76406581
82Glycerolipid metabolism_Homo sapiens_hsa005610.75665091
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73932466
84Fatty acid biosynthesis_Homo sapiens_hsa000610.73398040
85mRNA surveillance pathway_Homo sapiens_hsa030150.73295785
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72301237
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.71800598
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.71678660
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71034450
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70758643
91Antigen processing and presentation_Homo sapiens_hsa046120.69357134
92DNA replication_Homo sapiens_hsa030300.69333592
93Pancreatic cancer_Homo sapiens_hsa052120.67941984
94Sphingolipid metabolism_Homo sapiens_hsa006000.66328378
95Regulation of autophagy_Homo sapiens_hsa041400.66207902
96Carbon metabolism_Homo sapiens_hsa012000.65818170
97Circadian rhythm_Homo sapiens_hsa047100.64596806
98Tyrosine metabolism_Homo sapiens_hsa003500.62546661
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.61931173
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61513908
101Oocyte meiosis_Homo sapiens_hsa041140.61016541
102Toxoplasmosis_Homo sapiens_hsa051450.60852590
103Osteoclast differentiation_Homo sapiens_hsa043800.60198568
104Pentose phosphate pathway_Homo sapiens_hsa000300.59222558
105Renin-angiotensin system_Homo sapiens_hsa046140.58661293
106Adherens junction_Homo sapiens_hsa045200.58576885
107Viral carcinogenesis_Homo sapiens_hsa052030.57483414
108Non-small cell lung cancer_Homo sapiens_hsa052230.56862685
109mTOR signaling pathway_Homo sapiens_hsa041500.56171974
110Prostate cancer_Homo sapiens_hsa052150.55803550
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54875805
112Dorso-ventral axis formation_Homo sapiens_hsa043200.53976676
113AMPK signaling pathway_Homo sapiens_hsa041520.53200659
114FoxO signaling pathway_Homo sapiens_hsa040680.52206959
115Type II diabetes mellitus_Homo sapiens_hsa049300.52106547
116Vitamin digestion and absorption_Homo sapiens_hsa049770.52009878
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51100594
118Thyroid cancer_Homo sapiens_hsa052160.50788393
119Bladder cancer_Homo sapiens_hsa052190.50690457
120* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49863511
121Focal adhesion_Homo sapiens_hsa045100.49022384
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.48573434
123African trypanosomiasis_Homo sapiens_hsa051430.48068160
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47443949
125Platelet activation_Homo sapiens_hsa046110.47281181
126N-Glycan biosynthesis_Homo sapiens_hsa005100.46528184
127One carbon pool by folate_Homo sapiens_hsa006700.46256377
128Hematopoietic cell lineage_Homo sapiens_hsa046400.46155681
129Protein digestion and absorption_Homo sapiens_hsa049740.45776488
130Proteoglycans in cancer_Homo sapiens_hsa052050.45120622
131Glucagon signaling pathway_Homo sapiens_hsa049220.44967526
132Ether lipid metabolism_Homo sapiens_hsa005650.43583247
133Inositol phosphate metabolism_Homo sapiens_hsa005620.43375198
134* Metabolic pathways_Homo sapiens_hsa011000.42773804
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42280111
136Biosynthesis of amino acids_Homo sapiens_hsa012300.41880732
137Leishmaniasis_Homo sapiens_hsa051400.41590632
138Amoebiasis_Homo sapiens_hsa051460.41462668
139Acute myeloid leukemia_Homo sapiens_hsa052210.40522865
140Colorectal cancer_Homo sapiens_hsa052100.39707211
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39046937
142Hepatitis C_Homo sapiens_hsa051600.38917665
143Purine metabolism_Homo sapiens_hsa002300.38715243
144Legionellosis_Homo sapiens_hsa051340.38559677
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38519349
146Thyroid hormone synthesis_Homo sapiens_hsa049180.38210876
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36860351
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.36639590
149MicroRNAs in cancer_Homo sapiens_hsa052060.34684892
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34165930
151Endometrial cancer_Homo sapiens_hsa052130.34044391
152Hepatitis B_Homo sapiens_hsa051610.33339729
153Insulin signaling pathway_Homo sapiens_hsa049100.33271946
154PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31842548
155Pyrimidine metabolism_Homo sapiens_hsa002400.31227883
156Base excision repair_Homo sapiens_hsa034100.30028660
157Tight junction_Homo sapiens_hsa045300.27986867

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