C1GALT1C1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)6.11386489
2proteasome assembly (GO:0043248)6.01080084
3Golgi transport vesicle coating (GO:0048200)4.96392569
4COPI coating of Golgi vesicle (GO:0048205)4.96392569
5fatty acid elongation (GO:0030497)4.44089898
6regulation of cellular amino acid metabolic process (GO:0006521)4.28783126
7negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.25687299
8positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.25206653
9central nervous system myelination (GO:0022010)4.19884301
10axon ensheathment in central nervous system (GO:0032291)4.19884301
11regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.10773127
12respiratory chain complex IV assembly (GO:0008535)4.03394424
13lactate metabolic process (GO:0006089)4.01929121
14protein maturation by protein folding (GO:0022417)3.99345019
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.99188110
16cullin deneddylation (GO:0010388)3.98620949
17ER overload response (GO:0006983)3.94561138
18negative regulation of ligase activity (GO:0051352)3.87657819
19negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.87657819
20cytochrome complex assembly (GO:0017004)3.80963869
21DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78761331
22mitochondrial respiratory chain complex assembly (GO:0033108)3.77843523
23protein deneddylation (GO:0000338)3.77794760
24nucleotide transmembrane transport (GO:1901679)3.69770371
25intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.67843077
26signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.67843077
27anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67668825
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.67586741
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.67586741
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.67586741
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.59990550
32L-phenylalanine catabolic process (GO:0006559)3.59990550
33positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.54277213
34signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47803415
35signal transduction involved in DNA damage checkpoint (GO:0072422)3.47803415
36maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.47787363
37mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47560975
38antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.46341067
39positive regulation of ligase activity (GO:0051351)3.42214031
40signal transduction involved in cell cycle checkpoint (GO:0072395)3.40995465
41peptidyl-histidine modification (GO:0018202)3.39906586
42positive regulation of actin filament depolymerization (GO:0030836)3.34141683
43branched-chain amino acid catabolic process (GO:0009083)3.33150402
44ribosome assembly (GO:0042255)3.32434551
45peptide hormone processing (GO:0016486)3.31684273
46antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29082774
47pteridine-containing compound biosynthetic process (GO:0042559)3.28847097
48water-soluble vitamin biosynthetic process (GO:0042364)3.26095800
49C-terminal protein lipidation (GO:0006501)3.25058636
50regulation of mitochondrial translation (GO:0070129)3.18818771
51platelet dense granule organization (GO:0060155)3.18183392
52chaperone-mediated protein transport (GO:0072321)3.16422572
53phagosome maturation (GO:0090382)3.16006437
54energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.15035630
55ATP hydrolysis coupled proton transport (GO:0015991)3.15035630
56protein retention in ER lumen (GO:0006621)3.11138929
57pH reduction (GO:0045851)3.10830575
58regulation of cellular amine metabolic process (GO:0033238)3.08044568
59inner mitochondrial membrane organization (GO:0007007)3.07413475
60magnesium ion transport (GO:0015693)3.05738310
61protein heterotetramerization (GO:0051290)3.04519504
62L-phenylalanine metabolic process (GO:0006558)3.03410680
63erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03410680
64regulation of ubiquitin-protein transferase activity (GO:0051438)3.03305542
65mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.02747196
66C-terminal protein amino acid modification (GO:0018410)3.01487911
67neutrophil activation involved in immune response (GO:0002283)2.99711792
68transferrin transport (GO:0033572)2.98103971
69regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.97292596
70regulation of ligase activity (GO:0051340)2.95428054
71intracellular pH reduction (GO:0051452)2.95140417
72antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.92010981
73regulation of metalloenzyme activity (GO:0048552)2.91989364
74positive regulation of cell cycle arrest (GO:0071158)2.91750834
75COPII vesicle coating (GO:0048208)2.90652019
76positive regulation of protein autophosphorylation (GO:0031954)2.90198674
77negative regulation of protein ubiquitination (GO:0031397)2.89855905
78respiratory electron transport chain (GO:0022904)2.89210713
79dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.87165412
80protein neddylation (GO:0045116)2.85701816
81long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.85402187
82establishment of integrated proviral latency (GO:0075713)2.84828922
83preassembly of GPI anchor in ER membrane (GO:0016254)2.84583174
84ATP synthesis coupled proton transport (GO:0015986)2.84299314
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.84299314
86negative regulation of neurotransmitter secretion (GO:0046929)2.83512890
87ferric iron transport (GO:0015682)2.82939323
88trivalent inorganic cation transport (GO:0072512)2.82939323
89lipid particle organization (GO:0034389)2.81415407
90electron transport chain (GO:0022900)2.81355399
91aldehyde catabolic process (GO:0046185)2.79559490
92L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79237713
93negative regulation of neurotransmitter transport (GO:0051589)2.79018590
94sequestering of metal ion (GO:0051238)2.78520496
95DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.78459206
96xenobiotic catabolic process (GO:0042178)2.76974636
97RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76143258
98tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76143258
99regulation of glucokinase activity (GO:0033131)2.73802488
100regulation of hexokinase activity (GO:1903299)2.73802488
101cholesterol biosynthetic process (GO:0006695)2.72887078
102protein K11-linked ubiquitination (GO:0070979)2.71296497
103positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70883111
104mannosylation (GO:0097502)2.70325128
105rRNA modification (GO:0000154)2.67824324
106angiotensin maturation (GO:0002003)2.66423906
107negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.65769962
108peptide metabolic process (GO:0006518)2.64920798
109exocrine pancreas development (GO:0031017)2.63793307
110ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.62735135
111DNA double-strand break processing (GO:0000729)2.61747908
112endocrine pancreas development (GO:0031018)2.61380205
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60250502
114membrane budding (GO:0006900)2.58959628
115amyloid precursor protein metabolic process (GO:0042982)2.58921921
116glycerol ether metabolic process (GO:0006662)2.58604488
117long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.57491951
118L-methionine salvage (GO:0071267)2.57466538
119L-methionine biosynthetic process (GO:0071265)2.57466538
120amino acid salvage (GO:0043102)2.57466538
121very long-chain fatty acid metabolic process (GO:0000038)2.57137161
122adenosine metabolic process (GO:0046085)2.56491735
123organelle disassembly (GO:1903008)2.55382793
124maturation of 5.8S rRNA (GO:0000460)2.53189998
125fatty-acyl-CoA biosynthetic process (GO:0046949)2.52473157
126response to redox state (GO:0051775)2.51260833
127keratinocyte development (GO:0003334)2.50555161
128protein targeting to mitochondrion (GO:0006626)2.50140161
129purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50096681
1303-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50096681
131protein complex biogenesis (GO:0070271)2.49081585
132ether metabolic process (GO:0018904)2.47522921
133zinc ion transport (GO:0006829)2.47316497
134long-chain fatty acid biosynthetic process (GO:0042759)2.46980144
135regulation of amyloid precursor protein catabolic process (GO:1902991)2.46920113
136fucose metabolic process (GO:0006004)2.46896914
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.46409282
138termination of RNA polymerase III transcription (GO:0006386)2.46409282
139GDP-mannose metabolic process (GO:0019673)2.45865850
140positive regulation of glycoprotein biosynthetic process (GO:0010560)2.45840265
141protein-cofactor linkage (GO:0018065)2.45821432
142peroxisome fission (GO:0016559)2.45143397
143fatty-acyl-CoA metabolic process (GO:0035337)2.45101356
144positive regulation of glycoprotein metabolic process (GO:1903020)2.43221910
145sterol biosynthetic process (GO:0016126)2.43211379
146nucleotide transport (GO:0006862)2.42025176
147substantia nigra development (GO:0021762)2.41101494
148amyloid precursor protein catabolic process (GO:0042987)2.40837751
149presynaptic membrane assembly (GO:0097105)2.35613004
150glutathione biosynthetic process (GO:0006750)2.34344762
151ER to Golgi vesicle-mediated transport (GO:0006888)2.32317191
152GPI anchor biosynthetic process (GO:0006506)2.31944685
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.31236314
154mitochondrial respiratory chain complex I assembly (GO:0032981)2.31236314
155NADH dehydrogenase complex assembly (GO:0010257)2.31236314
156thioester biosynthetic process (GO:0035384)2.30811737
157acyl-CoA biosynthetic process (GO:0071616)2.30811737
158regulation of beta-amyloid formation (GO:1902003)2.30746604
159regulation of type B pancreatic cell apoptotic process (GO:2000674)2.29922525
160cellular copper ion homeostasis (GO:0006878)2.27903303
161respiratory burst (GO:0045730)2.27853698
162toxin metabolic process (GO:0009404)2.26374751
163cell redox homeostasis (GO:0045454)2.26053562
164cofactor catabolic process (GO:0051187)2.25614147
165glycosylceramide metabolic process (GO:0006677)2.24833564
166nonribosomal peptide biosynthetic process (GO:0019184)2.24818061
167positive regulation of cellular amine metabolic process (GO:0033240)2.23665233
168negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.21542930
169hydrogen ion transmembrane transport (GO:1902600)2.20898625
170protein N-linked glycosylation via asparagine (GO:0018279)2.20375709
171presynaptic membrane organization (GO:0097090)2.19891386
172succinate metabolic process (GO:0006105)2.19881674
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.19650102
174proton transport (GO:0015992)2.17557856
175intestinal cholesterol absorption (GO:0030299)2.16690206
176GPI anchor metabolic process (GO:0006505)2.16441608
177peroxisome organization (GO:0007031)2.16020537
178hydrogen transport (GO:0006818)2.14889975
179dopamine biosynthetic process (GO:0042416)2.14843628
180regulation of dopamine metabolic process (GO:0042053)2.14675428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.58022771
2EST1_17652178_ChIP-ChIP_JURKAT_Human3.28556170
3GBX2_23144817_ChIP-Seq_PC3_Human3.17164973
4ELK1_19687146_ChIP-ChIP_HELA_Human3.16056268
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.91619622
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75007941
7PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.54632991
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53697494
9TAF15_26573619_Chip-Seq_HEK293_Human2.53391180
10VDR_22108803_ChIP-Seq_LS180_Human2.51361418
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.41929786
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41143348
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36847137
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15871537
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12110889
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.09938090
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.09749032
18VDR_23849224_ChIP-Seq_CD4+_Human2.09103616
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07474766
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.02907919
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00537025
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.98713275
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.95628677
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.95628677
25GATA1_22025678_ChIP-Seq_K562_Human1.93621528
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90142936
27HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88599815
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.86485515
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85674553
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.83947367
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82233634
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80930572
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.78661158
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76660621
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.72383963
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71988681
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70877093
38P300_19829295_ChIP-Seq_ESCs_Human1.69737633
39ZNF274_21170338_ChIP-Seq_K562_Hela1.67209337
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.65677399
41FOXP3_21729870_ChIP-Seq_TREG_Human1.59847202
42ER_23166858_ChIP-Seq_MCF-7_Human1.59796432
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59188923
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56417536
45DCP1A_22483619_ChIP-Seq_HELA_Human1.52927676
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52107464
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51019019
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.50681647
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49948823
50* EWS_26573619_Chip-Seq_HEK293_Human1.49946771
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.48245395
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46674103
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46595249
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45844287
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45386052
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44351043
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43101909
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.40726118
59IGF1R_20145208_ChIP-Seq_DFB_Human1.38286745
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.35757025
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33995994
62SOX2_20726797_ChIP-Seq_SW620_Human1.33118411
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.33041761
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.32513518
65RXR_22158963_ChIP-Seq_LIVER_Mouse1.29968186
66SOX2_19829295_ChIP-Seq_ESCs_Human1.29178354
67NANOG_19829295_ChIP-Seq_ESCs_Human1.29178354
68HTT_18923047_ChIP-ChIP_STHdh_Human1.26390817
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24971093
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24690711
71MYC_18555785_ChIP-Seq_MESCs_Mouse1.23841701
72AR_21909140_ChIP-Seq_LNCAP_Human1.23263002
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23225231
74FUS_26573619_Chip-Seq_HEK293_Human1.22729550
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.22604420
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22322408
77SMAD4_21799915_ChIP-Seq_A2780_Human1.21666925
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21411024
79* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20509269
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20459913
81MYC_18940864_ChIP-ChIP_HL60_Human1.20451092
82* GABP_19822575_ChIP-Seq_HepG2_Human1.19730187
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.19360136
84AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18024519
85FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17251054
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16250200
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.16063502
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15896346
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.15691307
90EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13743904
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13667024
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.12910723
93LXR_22158963_ChIP-Seq_LIVER_Mouse1.12587105
94P53_22387025_ChIP-Seq_ESCs_Mouse1.12379448
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.12358598
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11756513
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10833626
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09961662
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09941853
100FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09763137
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09677785
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09347036
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.09096856
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08683381
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07786165
106BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07592803
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06826644
108* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06752955
109BRD4_25478319_ChIP-Seq_HGPS_Human1.06488673
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05196470
111SALL4_22934838_ChIP-ChIP_CD34+_Human1.04490206
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.04123235
113SRF_21415370_ChIP-Seq_HL-1_Mouse1.03422989
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03177156
115ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02581563
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02469912
117SMAD_19615063_ChIP-ChIP_OVARY_Human1.02154567
118TP53_18474530_ChIP-ChIP_U2OS_Human1.02022502
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01409195
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.01409195
121SOX2_18555785_Chip-Seq_ESCs_Mouse1.00896228
122CDX2_22108803_ChIP-Seq_LS180_Human1.00306783
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00244328
124TFEB_21752829_ChIP-Seq_HELA_Human1.00062031
125CJUN_26792858_Chip-Seq_BT549_Human0.99615444
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.99030420
127MTF2_20144788_ChIP-Seq_MESCs_Mouse0.98990295
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96941818
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96855081
130REST_19997604_ChIP-ChIP_NEURONS_Mouse0.96846230
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.96515950
132SMAD1_18555785_Chip-Seq_ESCs_Mouse0.96146609
133PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95234137
134ELF5_23300383_ChIP-Seq_T47D_Human0.94595767
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94399111
136JUN_21703547_ChIP-Seq_K562_Human0.93511325
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.93310056
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.93293004
139RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93181554
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.93142589
141AR_25329375_ChIP-Seq_VCAP_Human0.92936772
142STAT3_23295773_ChIP-Seq_U87_Human0.92728174
143MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91386330
144RUNX2_22187159_ChIP-Seq_PCA_Human0.91093778
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90844139
146TP53_22573176_ChIP-Seq_HFKS_Human0.90776762
147CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90128278
148MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89826673
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88900801
150PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88862907
151P300_18555785_Chip-Seq_ESCs_Mouse0.87923479
152* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87249952
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.86538357
154BCAT_22108803_ChIP-Seq_LS180_Human0.86527523
155EOMES_21245162_ChIP-Seq_HESCs_Human0.86509044
156KDM2B_26808549_Chip-Seq_REH_Human0.86269657
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85838388
158NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85769277
159AR_20517297_ChIP-Seq_VCAP_Human0.85017372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.66445706
2MP0003183_abnormal_peptide_metabolism3.39266593
3MP0004043_abnormal_pH_regulation3.30942076
4MP0000569_abnormal_digit_pigmentation2.85529737
5MP0002139_abnormal_hepatobiliary_system2.67129897
6MP0005058_abnormal_lysosome_morphology2.66343572
7MP0002938_white_spotting2.42632029
8MP0002163_abnormal_gland_morphology2.39241998
9MP0009780_abnormal_chondrocyte_physiolo2.31852266
10* MP0006054_spinal_hemorrhage2.30606204
11MP0000372_irregular_coat_pigmentation2.30228629
12MP0005365_abnormal_bile_salt2.28702261
13MP0002876_abnormal_thyroid_physiology2.28315921
14MP0010386_abnormal_urinary_bladder2.25840741
15MP0000920_abnormal_myelination2.25669516
16MP0008875_abnormal_xenobiotic_pharmacok2.18692139
17MP0001666_abnormal_nutrient_absorption2.14962378
18MP0003806_abnormal_nucleotide_metabolis2.07124214
19MP0008438_abnormal_cutaneous_collagen2.05047039
20MP0003786_premature_aging2.04443119
21MP0004270_analgesia2.03805378
22MP0001529_abnormal_vocalization2.01507160
23MP0000013_abnormal_adipose_tissue1.98992663
24MP0010234_abnormal_vibrissa_follicle1.98305781
25MP0003880_abnormal_central_pattern1.92727470
26MP0001986_abnormal_taste_sensitivity1.91767899
27MP0005085_abnormal_gallbladder_physiolo1.87236390
28MP0005360_urolithiasis1.87179474
29MP0008058_abnormal_DNA_repair1.84622476
30MP0003718_maternal_effect1.81473516
31MP0005645_abnormal_hypothalamus_physiol1.77027222
32MP0005408_hypopigmentation1.73797949
33MP0005379_endocrine/exocrine_gland_phen1.68570864
34MP0005220_abnormal_exocrine_pancreas1.66182816
35MP0002693_abnormal_pancreas_physiology1.64241826
36MP0005083_abnormal_biliary_tract1.63733355
37MP0002837_dystrophic_cardiac_calcinosis1.62834239
38MP0005332_abnormal_amino_acid1.60870096
39MP0005646_abnormal_pituitary_gland1.58411200
40MP0000427_abnormal_hair_cycle1.57432397
41MP0005084_abnormal_gallbladder_morpholo1.56742841
42MP0006072_abnormal_retinal_apoptosis1.55310382
43MP0001905_abnormal_dopamine_level1.55075900
44MP0002909_abnormal_adrenal_gland1.54153793
45MP0001984_abnormal_olfaction1.51367145
46MP0004272_abnormal_basement_membrane1.49111561
47MP0002064_seizures1.48509278
48MP0002272_abnormal_nervous_system1.47876459
49MP0003329_amyloid_beta_deposits1.47867827
50MP0002734_abnormal_mechanical_nocicepti1.46877196
51MP0004957_abnormal_blastocyst_morpholog1.45144501
52MP0002254_reproductive_system_inflammat1.44087223
53MP0001944_abnormal_pancreas_morphology1.42477902
54MP0003172_abnormal_lysosome_physiology1.41444405
55MP0001542_abnormal_bone_strength1.39323544
56MP0003868_abnormal_feces_composition1.38754199
57MP0003011_delayed_dark_adaptation1.37705469
58MP0003690_abnormal_glial_cell1.37689571
59MP0005636_abnormal_mineral_homeostasis1.36227731
60MP0001664_abnormal_digestion1.35476757
61MP0002736_abnormal_nociception_after1.35473787
62MP0003186_abnormal_redox_activity1.30306755
63MP0001764_abnormal_homeostasis1.30217056
64MP0001765_abnormal_ion_homeostasis1.27446881
65MP0004019_abnormal_vitamin_homeostasis1.26996183
66MP0000604_amyloidosis1.26261065
67MP0002229_neurodegeneration1.25331748
68MP0005367_renal/urinary_system_phenotyp1.24564238
69MP0000516_abnormal_urinary_system1.24564238
70MP0009643_abnormal_urine_homeostasis1.23426017
71MP0005395_other_phenotype1.22741491
72MP0005165_increased_susceptibility_to1.21352070
73MP0000358_abnormal_cell_content/1.21075696
74MP0009046_muscle_twitch1.20059074
75MP0002277_abnormal_respiratory_mucosa1.19253202
76MP0004782_abnormal_surfactant_physiolog1.18784941
77MP0000647_abnormal_sebaceous_gland1.18586941
78MP0006036_abnormal_mitochondrial_physio1.18131306
79MP0004142_abnormal_muscle_tone1.17775156
80MP0002295_abnormal_pulmonary_circulatio1.16021101
81MP0003634_abnormal_glial_cell1.14261100
82MP0000230_abnormal_systemic_arterial1.14213188
83MP0001970_abnormal_pain_threshold1.14008955
84MP0002102_abnormal_ear_morphology1.13284622
85MP0005535_abnormal_body_temperature1.13249309
86MP0003724_increased_susceptibility_to1.13041231
87MP0004264_abnormal_extraembryonic_tissu1.10614287
88MP0002733_abnormal_thermal_nociception1.08872740
89MP0005174_abnormal_tail_pigmentation1.08657658
90MP0004147_increased_porphyrin_level1.08275805
91MP0002735_abnormal_chemical_nociception1.08029690
92MP0004215_abnormal_myocardial_fiber1.07809355
93MP0009745_abnormal_behavioral_response1.07443482
94MP0002078_abnormal_glucose_homeostasis1.06861263
95MP0005075_abnormal_melanosome_morpholog1.05395953
96MP0001968_abnormal_touch/_nociception1.04577351
97MP0001756_abnormal_urination1.03789735
98MP0005584_abnormal_enzyme/coenzyme_acti1.01571287
99MP0008260_abnormal_autophagy1.01459532
100MP0001243_abnormal_dermal_layer1.00941519
101MP0002118_abnormal_lipid_homeostasis1.00703698
102MP0001486_abnormal_startle_reflex1.00669033
103MP0003191_abnormal_cellular_cholesterol0.99878066
104MP0003950_abnormal_plasma_membrane0.98553420
105MP0003635_abnormal_synaptic_transmissio0.98165612
106MP0002090_abnormal_vision0.97438076
107MP0001501_abnormal_sleep_pattern0.96949486
108MP0009697_abnormal_copulation0.96514454
109MP0000613_abnormal_salivary_gland0.96459987
110MP0006035_abnormal_mitochondrial_morpho0.95741362
111MP0005551_abnormal_eye_electrophysiolog0.95576918
112MP0010094_abnormal_chromosome_stability0.95326461
113MP0005310_abnormal_salivary_gland0.94844368
114MP0002282_abnormal_trachea_morphology0.94355228
115MP0008004_abnormal_stomach_pH0.94288837
116MP0002138_abnormal_hepatobiliary_system0.94066314
117MP0003656_abnormal_erythrocyte_physiolo0.92929180
118MP0002572_abnormal_emotion/affect_behav0.92770368
119* MP0003633_abnormal_nervous_system0.91617618
120MP0005253_abnormal_eye_physiology0.90606390
121MP0010352_gastrointestinal_tract_polyps0.90384291
122MP0005164_abnormal_response_to0.90281635
123MP0008932_abnormal_embryonic_tissue0.89842926
124MP0000681_abnormal_thyroid_gland0.87547663
125MP0003252_abnormal_bile_duct0.86664777
126MP0002234_abnormal_pharynx_morphology0.86574605
127MP0006276_abnormal_autonomic_nervous0.85611180
128MP0002877_abnormal_melanocyte_morpholog0.85432753
129MP0002177_abnormal_outer_ear0.84609255
130MP0003283_abnormal_digestive_organ0.84120914
131MP0000749_muscle_degeneration0.84025097
132MP0003890_abnormal_embryonic-extraembry0.83839076
133MP0003941_abnormal_skin_development0.83795802
134MP0010329_abnormal_lipoprotein_level0.83541126
135MP0004885_abnormal_endolymph0.83304135
136MP0002419_abnormal_innate_immunity0.83236184
137MP0002168_other_aberrant_phenotype0.82187346
138MP0010030_abnormal_orbit_morphology0.82151621
139MP0005319_abnormal_enzyme/_coenzyme0.82008273
140MP0008877_abnormal_DNA_methylation0.81198143
141MP0001533_abnormal_skeleton_physiology0.80943293
142MP0001440_abnormal_grooming_behavior0.80782275
143MP0003075_altered_response_to0.80729725
144MP0000639_abnormal_adrenal_gland0.80481888
145MP0008775_abnormal_heart_ventricle0.80074172
146MP0006082_CNS_inflammation0.79277686
147MP0002063_abnormal_learning/memory/cond0.78882535
148MP0003959_abnormal_lean_body0.78768713
149MP0010678_abnormal_skin_adnexa0.77874545
150MP0001324_abnormal_eye_pigmentation0.75328617
151MP0002060_abnormal_skin_morphology0.73070269
152MP0005410_abnormal_fertilization0.68591588
153MP0005376_homeostasis/metabolism_phenot0.68480134
154MP0005330_cardiomyopathy0.68068011
155MP0001881_abnormal_mammary_gland0.66514947
156MP0003137_abnormal_impulse_conducting0.65579775
157MP0002233_abnormal_nose_morphology0.65482010
158MP0002160_abnormal_reproductive_system0.65425507
159MP0000538_abnormal_urinary_bladder0.64804603

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.87137913
2Abnormal mitochondria in muscle tissue (HP:0008316)3.67033045
3Acute encephalopathy (HP:0006846)3.57764697
4Pheochromocytoma (HP:0002666)3.53772089
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.47958424
6Neuroendocrine neoplasm (HP:0100634)3.43638745
7Methylmalonic acidemia (HP:0002912)3.18976781
8Progressive macrocephaly (HP:0004481)3.18055560
9Symptomatic seizures (HP:0011145)3.16749709
10Increased hepatocellular lipid droplets (HP:0006565)3.16470837
11Vacuolated lymphocytes (HP:0001922)3.16237219
12Abnormality of glycolysis (HP:0004366)3.08840217
13Increased serum pyruvate (HP:0003542)3.08840217
14Hypoglycemic seizures (HP:0002173)3.08132953
15Hyperinsulinemic hypoglycemia (HP:0000825)3.04487889
16Mitochondrial inheritance (HP:0001427)3.03914402
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.00477895
18Hypoglycemic coma (HP:0001325)3.00421063
19Abnormality of methionine metabolism (HP:0010901)2.97139512
20Ketoacidosis (HP:0001993)2.90353104
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.87167800
22Neurofibrillary tangles (HP:0002185)2.79058151
23Lipid accumulation in hepatocytes (HP:0006561)2.76476338
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.75552658
25Decreased activity of mitochondrial respiratory chain (HP:0008972)2.75552658
26Autoamputation (HP:0001218)2.74483090
27Hepatic necrosis (HP:0002605)2.70689402
28Exertional dyspnea (HP:0002875)2.68254811
29Abnormality of aspartate family amino acid metabolism (HP:0010899)2.65935658
30Abnormality of vitamin B metabolism (HP:0004340)2.62597759
31Hepatocellular necrosis (HP:0001404)2.61137496
32Increased CSF lactate (HP:0002490)2.57052500
33Lethargy (HP:0001254)2.56523845
34Abnormality of the anterior horn cell (HP:0006802)2.56067225
35Degeneration of anterior horn cells (HP:0002398)2.56067225
36Congenital, generalized hypertrichosis (HP:0004540)2.52613342
37Cerebral edema (HP:0002181)2.52197359
38Gout (HP:0001997)2.51230723
39Increased serum lactate (HP:0002151)2.50340194
40Intrahepatic cholestasis (HP:0001406)2.44719000
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43437043
42Dysostosis multiplex (HP:0000943)2.43402853
43Palpitations (HP:0001962)2.41156514
44Parakeratosis (HP:0001036)2.40421618
45Increased cerebral lipofuscin (HP:0011813)2.37424041
46Exercise intolerance (HP:0003546)2.35158126
47Generalized aminoaciduria (HP:0002909)2.35076346
48Conjugated hyperbilirubinemia (HP:0002908)2.34172454
49Amniotic constriction ring (HP:0009775)2.33643834
50Abnormality of placental membranes (HP:0011409)2.33643834
51Hypothermia (HP:0002045)2.31569655
52Fat malabsorption (HP:0002630)2.29198089
53Reduced antithrombin III activity (HP:0001976)2.29021459
54Delayed gross motor development (HP:0002194)2.24749030
55Retinal dysplasia (HP:0007973)2.24452888
56Protuberant abdomen (HP:0001538)2.22384502
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.20206372
58Abnormal protein N-linked glycosylation (HP:0012347)2.20206372
59Abnormal protein glycosylation (HP:0012346)2.20206372
60Abnormal glycosylation (HP:0012345)2.20206372
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.19801079
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.19801079
63Progressive neurologic deterioration (HP:0002344)2.19762929
64Abnormality of the intrinsic pathway (HP:0010989)2.19481550
65Aplasia/hypoplasia of the uterus (HP:0008684)2.19213308
66Leukodystrophy (HP:0002415)2.18968941
67Hyperventilation (HP:0002883)2.18931486
68Pancreatic islet-cell hyperplasia (HP:0004510)2.17703578
69Cerebral hemorrhage (HP:0001342)2.17394777
70Adrenal hypoplasia (HP:0000835)2.16253238
71Pancreatic fibrosis (HP:0100732)2.15403251
72Albinism (HP:0001022)2.12102563
73X-linked dominant inheritance (HP:0001423)2.11386102
74Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.11041108
75Steatorrhea (HP:0002570)2.10713493
76CNS demyelination (HP:0007305)2.10575780
77Ketosis (HP:0001946)2.09766064
78Diminished movement (HP:0002374)2.08311019
79Type I transferrin isoform profile (HP:0003642)2.07246872
80Medial flaring of the eyebrow (HP:0010747)2.05607327
81Akinesia (HP:0002304)2.05218371
82Disproportionate short-trunk short stature (HP:0003521)2.05166711
83Vascular calcification (HP:0004934)2.05117436
84Hypokinesia (HP:0002375)2.05008883
85Respiratory failure (HP:0002878)2.04454647
86Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04001979
87Pancreatic cysts (HP:0001737)2.03558581
88Increased circulating renin level (HP:0000848)2.03497754
89Intestinal atresia (HP:0011100)2.03085700
90Tongue fasciculations (HP:0001308)2.02847389
91Epileptiform EEG discharges (HP:0011182)2.02550248
92Proximal tubulopathy (HP:0000114)2.02453478
93Abnormality of endocrine pancreas physiology (HP:0012093)2.02145663
94Abnormality of the pancreatic islet cells (HP:0006476)2.02145663
95Abnormality of vitamin metabolism (HP:0100508)2.02036541
96Hypomagnesemia (HP:0002917)2.01629762
97Hyperglycemia (HP:0003074)2.01621894
98True hermaphroditism (HP:0010459)1.99565465
99Cardiovascular calcification (HP:0011915)1.99135111
100Hyperactive renin-angiotensin system (HP:0000841)1.98137290
101Renal Fanconi syndrome (HP:0001994)1.97991229
102Lactic acidosis (HP:0003128)1.95842261
103Renal cortical cysts (HP:0000803)1.94354417
104Glycosuria (HP:0003076)1.94346688
105Abnormality of urine glucose concentration (HP:0011016)1.94346688
106Nausea (HP:0002018)1.94307175
107Abnormality of alanine metabolism (HP:0010916)1.94125869
108Hyperalaninemia (HP:0003348)1.94125869
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94125869
110Acute hepatic failure (HP:0006554)1.93840510
111Congenital primary aphakia (HP:0007707)1.92976049
112EEG with generalized epileptiform discharges (HP:0011198)1.92810607
113Congenital ichthyosiform erythroderma (HP:0007431)1.92764372
114Mucopolysacchariduria (HP:0008155)1.92465892
115Urinary glycosaminoglycan excretion (HP:0003541)1.92465892
116Abnormality of the common coagulation pathway (HP:0010990)1.91828202
117Hypokalemic alkalosis (HP:0001949)1.91025370
118Abnormality of renal resorption (HP:0011038)1.90752853
119Type II lissencephaly (HP:0007260)1.90283890
120Cerebral inclusion bodies (HP:0100314)1.89321604
121Conjunctival hamartoma (HP:0100780)1.89150903
122Hypsarrhythmia (HP:0002521)1.87302021
123Large for gestational age (HP:0001520)1.87135284
124Abnormality of fatty-acid metabolism (HP:0004359)1.86878985
125Spastic paraparesis (HP:0002313)1.84596036
126Gait imbalance (HP:0002141)1.84245144
127Poor head control (HP:0002421)1.83978551
128Methylmalonic aciduria (HP:0012120)1.83735684
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.82582669
130Nephrogenic diabetes insipidus (HP:0009806)1.82526009
131Abnormality of glycolipid metabolism (HP:0010969)1.82459596
132Abnormality of liposaccharide metabolism (HP:0010968)1.82459596
133Abnormality of glycosphingolipid metabolism (HP:0004343)1.82459596
134Prolonged partial thromboplastin time (HP:0003645)1.81209407
135Atonic seizures (HP:0010819)1.80927847
136Sensory axonal neuropathy (HP:0003390)1.78623522
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.78326549
138Hypoplasia of the fovea (HP:0007750)1.78326549
139Abnormality of serum amino acid levels (HP:0003112)1.77486448
140Optic disc pallor (HP:0000543)1.76795599
141Molar tooth sign on MRI (HP:0002419)1.75989956
142Abnormality of midbrain morphology (HP:0002418)1.75989956
143Abnormality of purine metabolism (HP:0004352)1.75021294
144Bifid tongue (HP:0010297)1.74999899
145Abnormalities of placenta or umbilical cord (HP:0001194)1.74016763
146Epileptic encephalopathy (HP:0200134)1.73508503
147Epiphyseal stippling (HP:0010655)1.73030041
148Aplasia/Hypoplasia of the tongue (HP:0010295)1.71348960
149Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70663869
150Increased intramyocellular lipid droplets (HP:0012240)1.70663078
151Late onset (HP:0003584)1.70474249
1523-Methylglutaconic aciduria (HP:0003535)1.69750485
153Abnormality of magnesium homeostasis (HP:0004921)1.69682179
154Orthostatic hypotension (HP:0001278)1.68794422
155Abnormality of renin-angiotensin system (HP:0000847)1.68447121
156Hypobetalipoproteinemia (HP:0003563)1.68257291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.15242503
2TRIM283.08951313
3FRK3.06733505
4CASK3.00478919
5BUB12.89029133
6OXSR12.87179326
7STK392.75651761
8INSRR2.65098762
9MST42.56334394
10WNK42.54303623
11MAP3K122.48298928
12STK162.42545094
13NEK12.28640248
14MAP4K22.27290262
15PIK3CG2.10916139
16ACVR1B2.04636497
17BCR2.03546165
18TAOK32.03364504
19ARAF2.02954782
20VRK21.96637816
21PBK1.92079873
22MAPKAPK51.77159977
23PLK31.74358126
24BMPR21.71915248
25MAPK151.66645802
26WNK31.66454903
27BMPR1B1.61656836
28SIK31.59625810
29LIMK11.49960492
30AKT31.49958711
31RIPK41.49050738
32BRSK21.42988224
33EIF2AK31.38455925
34BCKDK1.37622072
35CAMKK21.36825135
36PRPF4B1.34412488
37CAMK2B1.32522857
38NME11.31494478
39ZAK1.29965166
40ERN11.29707313
41MAP3K21.29592299
42ERBB41.29085536
43STK38L1.23385939
44SRPK11.22929752
45NME21.19530850
46CAMK2D1.16688648
47MAP2K71.14765285
48WEE11.14556424
49CDK191.14321320
50GRK11.13247455
51STK31.12606429
52PRKCE1.12226186
53MKNK21.11595787
54MET1.09293667
55PLK21.08561931
56PAK41.08110478
57MYLK1.08003204
58BRAF1.05933477
59EPHB10.98829793
60NTRK10.98500805
61WNK10.98354523
62ADRBK20.97906526
63PDK20.97662922
64UHMK10.97589299
65STK100.96193565
66MAPKAPK30.95862574
67MAP3K140.94438909
68PLK40.91989782
69CAMK2G0.91730413
70EIF2AK20.89226525
71PAK30.87575600
72LMTK20.86286253
73SGK2230.85830569
74SGK4940.85830569
75EPHA20.84674022
76GRK70.83861668
77TLK10.83506164
78ERBB30.83439233
79CAMK2A0.82535896
80TTK0.81007369
81CSNK1G30.80213264
82PNCK0.79555023
83PIM20.79336688
84MKNK10.78900187
85NTRK30.78820169
86NUAK10.78104618
87PRKCQ0.77355045
88HIPK20.76481067
89YES10.75645857
90TRPM70.72310048
91PLK10.70671518
92ILK0.69103816
93EPHA30.68849410
94PHKG20.68837083
95PHKG10.68837083
96TNIK0.67849465
97PRKCI0.65964098
98GRK50.65365253
99PASK0.65333209
100NEK60.64817729
101MST1R0.64104063
102STK240.63722773
103TYK20.63480118
104FGFR10.63315054
105DAPK10.63151290
106IRAK10.61754774
107IRAK40.57417007
108VRK10.56507884
109TESK20.56060101
110BRSK10.56038320
111MAP3K10.55331886
112TEC0.54734041
113CSNK1A1L0.54157651
114FGFR20.53551674
115NEK90.53476092
116ROCK20.52838818
117TGFBR20.52409242
118PRKG20.52385852
119CSNK1G20.52156898
120TESK10.52028391
121MAPK130.51528240
122MAP3K40.50763616
123MAP2K20.49413248
124CCNB10.48703783
125CDK50.48234851
126EPHA40.47881612
127ROCK10.47766762
128BLK0.47169048
129PRKCG0.46185667
130DYRK1A0.45530746
131MAP2K10.45433092
132TAF10.44627201
133CSNK1A10.44449944
134MAP3K130.43934884
135CSNK2A10.43757366
136ADRBK10.43412740
137TIE10.42538509
138ABL20.41552279
139PKN10.41339095
140AURKB0.40682681
141FER0.39773511
142TSSK60.39560328
143PTK2B0.38605957
144MAP2K60.38140661
145CSNK1G10.36849606
146PRKCD0.36008597
147PRKACA0.35854411
148PRKCH0.35779185
149CSNK2A20.34716045
150STK40.27820912
151SCYL20.27102234
152JAK10.26181037

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.98210129
2Sulfur metabolism_Homo sapiens_hsa009203.80545408
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.35890927
4Oxidative phosphorylation_Homo sapiens_hsa001903.08169662
5Fatty acid elongation_Homo sapiens_hsa000622.79106780
6Vibrio cholerae infection_Homo sapiens_hsa051102.75185506
7Collecting duct acid secretion_Homo sapiens_hsa049662.67102803
8Steroid biosynthesis_Homo sapiens_hsa001002.36568620
9Parkinsons disease_Homo sapiens_hsa050122.03723818
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.96236944
11Alzheimers disease_Homo sapiens_hsa050101.86343811
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.83090379
13Histidine metabolism_Homo sapiens_hsa003401.82745131
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.80029540
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72242645
16Lysosome_Homo sapiens_hsa041421.61542118
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60407160
18RNA polymerase_Homo sapiens_hsa030201.60181892
19Vitamin B6 metabolism_Homo sapiens_hsa007501.59399056
20Non-homologous end-joining_Homo sapiens_hsa034501.58418345
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55964642
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54776965
23Homologous recombination_Homo sapiens_hsa034401.54225501
24Phagosome_Homo sapiens_hsa041451.49805563
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46803750
26Rheumatoid arthritis_Homo sapiens_hsa053231.45104679
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44475008
28Synaptic vesicle cycle_Homo sapiens_hsa047211.43010691
29Folate biosynthesis_Homo sapiens_hsa007901.42110772
30Butanoate metabolism_Homo sapiens_hsa006501.35005213
31Other glycan degradation_Homo sapiens_hsa005111.33750577
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32097702
33One carbon pool by folate_Homo sapiens_hsa006701.30329451
34Sphingolipid metabolism_Homo sapiens_hsa006001.26500442
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25958346
36Mismatch repair_Homo sapiens_hsa034301.24527933
37Ether lipid metabolism_Homo sapiens_hsa005651.21595910
38Basal transcription factors_Homo sapiens_hsa030221.18850761
39Peroxisome_Homo sapiens_hsa041461.18092575
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17066511
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.15789131
42Pyruvate metabolism_Homo sapiens_hsa006201.14725280
43Nucleotide excision repair_Homo sapiens_hsa034201.10801856
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08838595
45Huntingtons disease_Homo sapiens_hsa050161.06519817
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05426558
47Pyrimidine metabolism_Homo sapiens_hsa002401.04369717
48Proteasome_Homo sapiens_hsa030501.02187978
49Propanoate metabolism_Homo sapiens_hsa006401.01660292
50Pancreatic secretion_Homo sapiens_hsa049721.00463606
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99262418
52N-Glycan biosynthesis_Homo sapiens_hsa005100.98812660
53GABAergic synapse_Homo sapiens_hsa047270.98289392
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97103219
55Insulin secretion_Homo sapiens_hsa049110.95148384
56Purine metabolism_Homo sapiens_hsa002300.86506767
57RNA degradation_Homo sapiens_hsa030180.85502487
58Regulation of autophagy_Homo sapiens_hsa041400.81957182
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79947937
60Retinol metabolism_Homo sapiens_hsa008300.79225704
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78868315
62Tryptophan metabolism_Homo sapiens_hsa003800.78807138
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78564369
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.77707605
65Renin-angiotensin system_Homo sapiens_hsa046140.77598697
66Carbon metabolism_Homo sapiens_hsa012000.76306232
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75698817
68Serotonergic synapse_Homo sapiens_hsa047260.75388441
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73642243
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72373067
71Fanconi anemia pathway_Homo sapiens_hsa034600.71221325
72Phenylalanine metabolism_Homo sapiens_hsa003600.70905734
73Type I diabetes mellitus_Homo sapiens_hsa049400.70824187
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.70535136
75Nicotine addiction_Homo sapiens_hsa050330.70394727
76Base excision repair_Homo sapiens_hsa034100.69992173
77* Metabolic pathways_Homo sapiens_hsa011000.69816383
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69731315
79Ribosome_Homo sapiens_hsa030100.69328407
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69147411
81Arginine and proline metabolism_Homo sapiens_hsa003300.69023540
82Linoleic acid metabolism_Homo sapiens_hsa005910.68950370
83Fatty acid metabolism_Homo sapiens_hsa012120.68277942
84DNA replication_Homo sapiens_hsa030300.67435572
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67026707
86RNA transport_Homo sapiens_hsa030130.65989659
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65282691
88Starch and sucrose metabolism_Homo sapiens_hsa005000.64183160
89Chemical carcinogenesis_Homo sapiens_hsa052040.63819015
90Glutathione metabolism_Homo sapiens_hsa004800.63566270
91Morphine addiction_Homo sapiens_hsa050320.62715920
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62278228
93Cardiac muscle contraction_Homo sapiens_hsa042600.61756484
94Fatty acid degradation_Homo sapiens_hsa000710.60875224
95Tyrosine metabolism_Homo sapiens_hsa003500.60814804
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60663896
97* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59171110
98Sulfur relay system_Homo sapiens_hsa041220.58942247
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58639321
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.58607827
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57682000
102Taste transduction_Homo sapiens_hsa047420.57610157
103Fat digestion and absorption_Homo sapiens_hsa049750.57601018
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57364681
105Vitamin digestion and absorption_Homo sapiens_hsa049770.57235520
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57081194
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55740220
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.55663588
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54342807
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53035568
111beta-Alanine metabolism_Homo sapiens_hsa004100.51687361
112Mineral absorption_Homo sapiens_hsa049780.51496440
113Spliceosome_Homo sapiens_hsa030400.49885236
114Circadian rhythm_Homo sapiens_hsa047100.49478085
115Arachidonic acid metabolism_Homo sapiens_hsa005900.48074966
116Thyroid hormone synthesis_Homo sapiens_hsa049180.46946869
117p53 signaling pathway_Homo sapiens_hsa041150.45917419
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45872943
119Nitrogen metabolism_Homo sapiens_hsa009100.44985722
120Legionellosis_Homo sapiens_hsa051340.43294378
121Circadian entrainment_Homo sapiens_hsa047130.42634496
122Arginine biosynthesis_Homo sapiens_hsa002200.40119121
123Cocaine addiction_Homo sapiens_hsa050300.39803526
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38045594
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37962382
126Selenocompound metabolism_Homo sapiens_hsa004500.37215403
127Complement and coagulation cascades_Homo sapiens_hsa046100.37164528
128ABC transporters_Homo sapiens_hsa020100.36408090
129Caffeine metabolism_Homo sapiens_hsa002320.36287729
130Dopaminergic synapse_Homo sapiens_hsa047280.35055652
131Galactose metabolism_Homo sapiens_hsa000520.31510465
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31407814
133Protein digestion and absorption_Homo sapiens_hsa049740.31083369
134Amphetamine addiction_Homo sapiens_hsa050310.30464173
135Oocyte meiosis_Homo sapiens_hsa041140.29984441
136Prion diseases_Homo sapiens_hsa050200.29249421
137Renin secretion_Homo sapiens_hsa049240.27926573

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