ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	lactate metabolic process (GO:0006089)	4.83178253
2	rRNA methylation (GO:0031167)	4.68441094
3	rRNA modification (GO:0000154)	4.56314086
4	positive regulation of catecholamine secretion (GO:0033605)	4.39958782
5	regulation of cholesterol esterification (GO:0010872)	4.29634877
6	regulation of glucokinase activity (GO:0033131)	4.12151844
7	regulation of hexokinase activity (GO:1903299)	4.12151844
8	regulation of mitochondrial translation (GO:0070129)	4.03711464
9	GMP metabolic process (GO:0046037)	3.88496045
10	phenylpropanoid metabolic process (GO:0009698)	3.83613833
11	regulation of receptor binding (GO:1900120)	3.56631845
12	chaperone-mediated protein complex assembly (GO:0051131)	3.45662694
13	proline biosynthetic process (GO:0006561)	3.44679757
14	regulation of cardioblast proliferation (GO:0003264)	3.31256042
15	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.31256042
16	protein maturation by protein folding (GO:0022417)	3.30979629
17	proteasome assembly (GO:0043248)	3.28727502
18	regulation of glucocorticoid metabolic process (GO:0031943)	3.27680967
19	tricarboxylic acid cycle (GO:0006099)	3.26571463
20	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.24403444
21	zinc ion transport (GO:0006829)	3.23467564
22	regulation of mitotic spindle organization (GO:0060236)	3.15330543
23	ribosomal large subunit biogenesis (GO:0042273)	3.11732356
24	ribosome assembly (GO:0042255)	3.11336902
25	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	3.11316583
26	biotin metabolic process (GO:0006768)	3.03590307
27	protein localization to chromosome, centromeric region (GO:0071459)	3.03551207
28	carnitine metabolic process (GO:0009437)	3.01553836
29	regulation of metalloenzyme activity (GO:0048552)	2.98629348
30	cellular zinc ion homeostasis (GO:0006882)	2.97757352
31	positive regulation of actin filament depolymerization (GO:0030836)	2.97249460
32	DNA unwinding involved in DNA replication (GO:0006268)	2.96807162
33	protein autoprocessing (GO:0016540)	2.89647039
34	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85930203
35	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.84142872
36	zinc ion transmembrane transport (GO:0071577)	2.83704390
37	adrenal gland development (GO:0030325)	2.77102141
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.76820204
39	regulation of type B pancreatic cell apoptotic process (GO:2000674)	2.74980580
40	mitochondrial RNA metabolic process (GO:0000959)	2.73376378
41	transcription from mitochondrial promoter (GO:0006390)	2.72572456
42	sequestering of metal ion (GO:0051238)	2.71475869
43	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.71378319
44	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.71378319
45	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.71378319
46	branched-chain amino acid catabolic process (GO:0009083)	2.70795630
47	regulation of gonadotropin secretion (GO:0032276)	2.70584778
48	regulation of cell proliferation involved in heart morphogenesis (GO:2000136)	2.70359759
49	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.70118628
50	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.69048949
51	purine nucleobase biosynthetic process (GO:0009113)	2.67586752
52	mitotic metaphase plate congression (GO:0007080)	2.66202066
53	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.64659113
54	negative regulation of ligase activity (GO:0051352)	2.64659113
55	pteridine-containing compound biosynthetic process (GO:0042559)	2.62884526
56	glomerular basement membrane development (GO:0032836)	2.62827584
57	regulation of cytokine secretion involved in immune response (GO:0002739)	2.61267322
58	nuclear pore organization (GO:0006999)	2.61213169
59	cranial nerve development (GO:0021545)	2.60376678
60	negative regulation of norepinephrine secretion (GO:0010700)	2.60102712
61	regulation of spindle organization (GO:0090224)	2.59720740
62	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.57512227
63	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.56453369
64	aerobic respiration (GO:0009060)	2.56000951
65	protein complex biogenesis (GO:0070271)	2.55876084
66	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.55516283
67	rRNA processing (GO:0006364)	2.54982082
68	high-density lipoprotein particle remodeling (GO:0034375)	2.54072939
69	attachment of spindle microtubules to kinetochore (GO:0008608)	2.53563706
70	nuclear pore complex assembly (GO:0051292)	2.52587514
71	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.51889959
72	plasma lipoprotein particle assembly (GO:0034377)	2.49968071
73	oxidative phosphorylation (GO:0006119)	2.48220808
74	outer ear morphogenesis (GO:0042473)	2.47657881
75	regulation of cellular amino acid metabolic process (GO:0006521)	2.47629750
76	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.47094815
77	rRNA metabolic process (GO:0016072)	2.46794224
78	proline metabolic process (GO:0006560)	2.45498133
79	amino-acid betaine metabolic process (GO:0006577)	2.45135815
80	energy homeostasis (GO:0097009)	2.43573309
81	nucleobase biosynthetic process (GO:0046112)	2.42243588
82	tetrahydrofolate metabolic process (GO:0046653)	2.41122563
83	glucocorticoid metabolic process (GO:0008211)	2.40402728
84	protein localization to kinetochore (GO:0034501)	2.39473471
85	regulation of dopamine secretion (GO:0014059)	2.39033407
86	succinate metabolic process (GO:0006105)	2.37936666
87	mitotic sister chromatid cohesion (GO:0007064)	2.37741849
88	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	2.37459961
89	metaphase plate congression (GO:0051310)	2.36557947
90	mitotic sister chromatid segregation (GO:0000070)	2.35247339
91	centriole replication (GO:0007099)	2.34247550
92	negative regulation of epidermal cell differentiation (GO:0045605)	2.33469447
93	DNA replication checkpoint (GO:0000076)	2.32503533
94	peptidyl-histidine modification (GO:0018202)	2.32503176
95	regulation of organ formation (GO:0003156)	2.32064068
96	lysine catabolic process (GO:0006554)	2.30070945
97	lysine metabolic process (GO:0006553)	2.30070945
98	labyrinthine layer blood vessel development (GO:0060716)	2.29309203
99	negative regulation of lipase activity (GO:0060192)	2.28665209
100	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.28441295

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.11812641
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.41742600
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.71296902
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.15170249
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.11760568
6	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.05757965
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.97029994
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.92603768
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92455082
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.69336208
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.59494480
12	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.47214645
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.46651176
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.46505421
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.42562729
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.28501520
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.26976960
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25184085
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.25041592
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.23386272
21	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	2.19520891
22	PADI4_21655091_ChIP-ChIP_MCF-7_Human	2.18153814
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.17169658
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.11166635
25	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.09610533
26	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.07639046
27	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.06049965
28	KDM5A_27292631_Chip-Seq_BREAST_Human	2.05671344
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.01570298
30	DCP1A_22483619_ChIP-Seq_HELA_Human	2.00128793
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.85147308
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.81798194
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.78569806
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.76591189
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.75842352
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.75664544
37	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.71038412
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.64898114
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63425479
40	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.62278592
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.62078235
42	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.58784714
43	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.58110515
44	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.57353308
45	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.55879502
46	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.50600391
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.49340650
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.46114529
49	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.45804991
50	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.44602375
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.39868888
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.39263983
53	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.38889998
54	ZNF263_19887448_ChIP-Seq_K562_Human	1.38782243
55	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37941651
56	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.37149401
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.34898595
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34136728
59	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.32816215
60	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.29234631
61	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29161059
62	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.28517035
63	ELF5_23300383_ChIP-Seq_T47D_Human	1.25494568
64	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.23540975
65	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21646827
66	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.18746678
67	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.18125474
68	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.18089653
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.16827039
70	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.10828172
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.05179697
72	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.04581950
73	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01160228
74	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.98421597
75	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.95905750
76	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.94776127
77	EOMES_21245162_ChIP-Seq_HESCs_Human	0.92766548
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91511974
79	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91222834
80	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89459350
81	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89103742
82	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.86980371
83	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.84869565
84	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.83982438
85	CHD1_26751641_Chip-Seq_LNCaP_Human	0.82335306
86	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.79742587
87	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.79344435
88	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.77816478
89	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.76754857
90	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.75847218
91	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.75676793
92	HTT_18923047_ChIP-ChIP_STHdh_Human	0.74730480
93	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.74350218
94	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.74109177
95	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.73590599
96	BRD4_25478319_ChIP-Seq_HGPS_Human	0.71519690
97	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	0.71215296
98	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.71097971
99	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.71094942
100	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.70503907

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	3.71172489
2	MP0002877_abnormal_melanocyte_morpholog	3.28837106
3	MP0000569_abnormal_digit_pigmentation	3.12223025
4	MP0002638_abnormal_pupillary_reflex	2.67884103
5	MP0010234_abnormal_vibrissa_follicle	2.21494779
6	MP0004272_abnormal_basement_membrane	2.16725119
7	MP0010030_abnormal_orbit_morphology	2.12525257
8	MP0000467_abnormal_esophagus_morphology	2.10282200
9	MP0003186_abnormal_redox_activity	2.08335267
10	MP0003283_abnormal_digestive_organ	2.07662919
11	MP0003718_maternal_effect	2.05447550
12	MP0003122_maternal_imprinting	1.92393664
13	MP0008058_abnormal_DNA_repair	1.86276556
14	MP0005084_abnormal_gallbladder_morpholo	1.86078964
15	MP0010094_abnormal_chromosome_stability	1.85768786
16	MP0006036_abnormal_mitochondrial_physio	1.79664931
17	MP0003121_genomic_imprinting	1.74350476
18	MP0002938_white_spotting	1.72534525
19	MP0005408_hypopigmentation	1.69676606
20	MP0009840_abnormal_foam_cell	1.68215480
21	MP0003123_paternal_imprinting	1.67203848
22	MP0003693_abnormal_embryo_hatching	1.65488952
23	MP0000013_abnormal_adipose_tissue	1.60251827
24	MP0000534_abnormal_ureter_morphology	1.58989715
25	MP0002837_dystrophic_cardiac_calcinosis	1.53990735
26	MP0003806_abnormal_nucleotide_metabolis	1.53223271
27	MP0001346_abnormal_lacrimal_gland	1.49687730
28	MP0005646_abnormal_pituitary_gland	1.45764364
29	MP0006072_abnormal_retinal_apoptosis	1.45414911
30	MP0008877_abnormal_DNA_methylation	1.45063149
31	MP0000639_abnormal_adrenal_gland	1.44978366
32	MP0003787_abnormal_imprinting	1.42026560
33	MP0010386_abnormal_urinary_bladder	1.37984995
34	MP0010352_gastrointestinal_tract_polyps	1.36896275
35	MP0003191_abnormal_cellular_cholesterol	1.33829793
36	MP0005220_abnormal_exocrine_pancreas	1.30662836
37	MP0004957_abnormal_blastocyst_morpholog	1.30048757
38	MP0001666_abnormal_nutrient_absorption	1.30032447
39	MP0001881_abnormal_mammary_gland	1.28276307
40	MP0003111_abnormal_nucleus_morphology	1.26924737
41	MP0010307_abnormal_tumor_latency	1.26898750
42	MP0003943_abnormal_hepatobiliary_system	1.24594043
43	MP0005389_reproductive_system_phenotype	1.24438937
44	MP0002928_abnormal_bile_duct	1.24206639
45	MP0005365_abnormal_bile_salt	1.22710115
46	MP0004782_abnormal_surfactant_physiolog	1.22610382
47	MP0006035_abnormal_mitochondrial_morpho	1.22514118
48	MP0004215_abnormal_myocardial_fiber	1.20369655
49	MP0001919_abnormal_reproductive_system	1.19389354
50	MP0005330_cardiomyopathy	1.18360891
51	MP0001944_abnormal_pancreas_morphology	1.18252326
52	MP0003942_abnormal_urinary_system	1.16511789
53	MP0002160_abnormal_reproductive_system	1.15339615
54	MP0002295_abnormal_pulmonary_circulatio	1.14898165
55	MP0010678_abnormal_skin_adnexa	1.14159678
56	MP0005636_abnormal_mineral_homeostasis	1.13836058
57	MP0001730_embryonic_growth_arrest	1.11485998
58	MP0001697_abnormal_embryo_size	1.10305369
59	MP0001661_extended_life_span	1.10243823
60	MP0002822_catalepsy	1.05127421
61	MP0003315_abnormal_perineum_morphology	1.04188388
62	MP0003786_premature_aging	1.01732174
63	MP0000647_abnormal_sebaceous_gland	1.01314974
64	MP0000003_abnormal_adipose_tissue	1.01198859
65	MP0004233_abnormal_muscle_weight	1.00008659
66	MP0002177_abnormal_outer_ear	0.99335515
67	MP0008775_abnormal_heart_ventricle	0.98395829
68	MP0000516_abnormal_urinary_system	0.97909584
69	MP0005367_renal/urinary_system_phenotyp	0.97909584
70	MP0003077_abnormal_cell_cycle	0.96454966
71	MP0003329_amyloid_beta_deposits	0.95429947
72	MP0005395_other_phenotype	0.94201069
73	MP0009697_abnormal_copulation	0.94043440
74	MP0010329_abnormal_lipoprotein_level	0.92440076
75	MP0003950_abnormal_plasma_membrane	0.92208636
76	MP0005647_abnormal_sex_gland	0.91333469
77	MP0008932_abnormal_embryonic_tissue	0.89464066
78	MP0005197_abnormal_uvea_morphology	0.87982976
79	MP0000383_abnormal_hair_follicle	0.85326759
80	MP0002088_abnormal_embryonic_growth/wei	0.83111349
81	MP0001929_abnormal_gametogenesis	0.82945307
82	MP0004264_abnormal_extraembryonic_tissu	0.82696789
83	MP0003984_embryonic_growth_retardation	0.82386792
84	MP0003385_abnormal_body_wall	0.80791011
85	MP0002876_abnormal_thyroid_physiology	0.80693679
86	MP0002693_abnormal_pancreas_physiology	0.79737297
87	MP0003195_calcinosis	0.79667549
88	MP0002009_preneoplasia	0.77601193
89	MP0005380_embryogenesis_phenotype	0.77592825
90	MP0001672_abnormal_embryogenesis/_devel	0.77592825
91	MP0000427_abnormal_hair_cycle	0.77348831
92	MP0008995_early_reproductive_senescence	0.77244622
93	MP0001915_intracranial_hemorrhage	0.76128397
94	MP0000627_abnormal_mammary_gland	0.75542656
95	MP0002932_abnormal_joint_morphology	0.74624108
96	MP0000350_abnormal_cell_proliferation	0.73628874
97	MP0005379_endocrine/exocrine_gland_phen	0.72302714
98	MP0006276_abnormal_autonomic_nervous	0.71836800
99	MP0002084_abnormal_developmental_patter	0.70543669
100	MP0002751_abnormal_autonomic_nervous	0.67903991

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoglycemic seizures (HP:0002173)	4.67416388
2	Increased serum pyruvate (HP:0003542)	4.07098306
3	Hypoglycemic coma (HP:0001325)	3.96814833
4	Hyperinsulinemic hypoglycemia (HP:0000825)	3.70713027
5	Abnormality of glycolysis (HP:0004366)	3.55532426
6	Hypobetalipoproteinemia (HP:0003563)	3.37323712
7	Congenital primary aphakia (HP:0007707)	3.26364835
8	Gait imbalance (HP:0002141)	3.06255040
9	Medial flaring of the eyebrow (HP:0010747)	3.03847065
10	Overlapping toe (HP:0001845)	2.92942307
11	Ketoacidosis (HP:0001993)	2.84262535
12	Spastic diplegia (HP:0001264)	2.78526797
13	Vaginal fistula (HP:0004320)	2.78084189
14	Rectovaginal fistula (HP:0000143)	2.76957910
15	Rectal fistula (HP:0100590)	2.76957910
16	Nephrogenic diabetes insipidus (HP:0009806)	2.73863693
17	Symptomatic seizures (HP:0011145)	2.71439362
18	Bilateral sensorineural hearing impairment (HP:0008619)	2.66714092
19	Poor coordination (HP:0002370)	2.58239619
20	Vaginal atresia (HP:0000148)	2.57934827
21	Hypolipoproteinemia (HP:0010981)	2.56565336
22	Abnormality of methionine metabolism (HP:0010901)	2.56187428
23	Genital tract atresia (HP:0001827)	2.53240229
24	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.43396215
25	Acute encephalopathy (HP:0006846)	2.36780369
26	Abnormality of alanine metabolism (HP:0010916)	2.30891731
27	Hyperalaninemia (HP:0003348)	2.30891731
28	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.30891731
29	Hypokinesia (HP:0002375)	2.29496785
30	Hepatic necrosis (HP:0002605)	2.28833179
31	Acute necrotizing encephalopathy (HP:0006965)	2.28713292
32	Spastic paraparesis (HP:0002313)	2.27776224
33	Urethral obstruction (HP:0000796)	2.17282534
34	Intestinal fistula (HP:0100819)	2.17173387
35	Aplasia/Hypoplasia of the lens (HP:0008063)	2.14576041
36	Increased CSF lactate (HP:0002490)	2.13924961
37	Asymmetry of the thorax (HP:0001555)	2.12142749
38	Delayed CNS myelination (HP:0002188)	2.08503004
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.07560854
40	Posterior subcapsular cataract (HP:0007787)	2.07114376
41	Steatorrhea (HP:0002570)	2.05788211
42	Renal cortical cysts (HP:0000803)	2.05631781
43	Metaphyseal dysplasia (HP:0100255)	2.05103088
44	Intestinal atresia (HP:0011100)	2.04321356
45	Deep venous thrombosis (HP:0002625)	2.03544415
46	Large for gestational age (HP:0001520)	2.03268735
47	Abnormality of the tricuspid valve (HP:0001702)	2.02266510
48	Anteriorly placed anus (HP:0001545)	2.01736978
49	Progressive macrocephaly (HP:0004481)	1.99644120
50	Increased hepatocellular lipid droplets (HP:0006565)	1.98447358
51	Glucose intolerance (HP:0000833)	1.95081409
52	Epiphyseal stippling (HP:0010655)	1.94819129
53	Tubulointerstitial nephritis (HP:0001970)	1.94627478
54	Short middle phalanx of the 5th finger (HP:0004220)	1.93935671
55	Abnormal hair laboratory examination (HP:0003328)	1.93180467
56	Abnormality of macular pigmentation (HP:0008002)	1.89960016
57	Adrenal hypoplasia (HP:0000835)	1.87686103
58	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.87274209
59	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.87274209
60	Conjunctival hamartoma (HP:0100780)	1.82556766
61	Broad foot (HP:0001769)	1.82370559
62	Abnormality of the costochondral junction (HP:0000919)	1.81511545
63	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.79657466
64	Microretrognathia (HP:0000308)	1.79442578
65	Secondary amenorrhea (HP:0000869)	1.78782957
66	Wide nose (HP:0000445)	1.77997538
67	Brushfield spots (HP:0001088)	1.77553818
68	Myoglobinuria (HP:0002913)	1.77414177
69	Paraparesis (HP:0002385)	1.75921769
70	Abnormality of the line of Schwalbe (HP:0008048)	1.75812044
71	Lipid accumulation in hepatocytes (HP:0006561)	1.74439625
72	Ketosis (HP:0001946)	1.73876164
73	Ectopic anus (HP:0004397)	1.73165609
74	Prolonged partial thromboplastin time (HP:0003645)	1.71823321
75	Central scotoma (HP:0000603)	1.71519463
76	Abnormalities of placenta or umbilical cord (HP:0001194)	1.71354029
77	Fat malabsorption (HP:0002630)	1.68754678
78	Abnormality of the fetal cardiovascular system (HP:0010948)	1.68322181
79	Abnormal umbilical cord blood vessels (HP:0011403)	1.68322181
80	Single umbilical artery (HP:0001195)	1.68322181
81	Tongue fasciculations (HP:0001308)	1.67622969
82	Lower limb hyperreflexia (HP:0002395)	1.65746832
83	Amyloidosis (HP:0011034)	1.64365968
84	Cutaneous melanoma (HP:0012056)	1.63551069
85	Hypoalphalipoproteinemia (HP:0003233)	1.62294251
86	Microglossia (HP:0000171)	1.61805979
87	Anal atresia (HP:0002023)	1.61064138
88	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.61045634
89	Abnormality of lateral ventricle (HP:0030047)	1.60740684
90	Mitochondrial inheritance (HP:0001427)	1.60200687
91	Vertebral compression fractures (HP:0002953)	1.59381122
92	Lethargy (HP:0001254)	1.59061276
93	Posterior embryotoxon (HP:0000627)	1.58376924
94	Cerebral edema (HP:0002181)	1.57687811
95	Decreased testicular size (HP:0008734)	1.56718420
96	Hypoplasia of the uterus (HP:0000013)	1.56514369
97	Brittle hair (HP:0002299)	1.54128269
98	Rib fusion (HP:0000902)	1.53324213
99	Hyperglycemia (HP:0003074)	1.52907666
100	Hypothermia (HP:0002045)	1.52566575

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	5.81573451
2	PBK	3.49783247
3	NUAK1	3.30379743
4	PDK2	2.77782309
5	LIMK1	2.62619320
6	DMPK	2.57199983
7	BUB1	2.49131963
8	NME2	2.46380274
9	MST4	2.39686649
10	FGFR2	2.38510895
11	SRPK1	2.33095083
12	ICK	2.18919143
13	FRK	2.01148827
14	NEK1	1.97674785
15	SCYL2	1.85763706
16	PASK	1.82766354
17	ILK	1.75880549
18	BCKDK	1.75298013
19	PDGFRA	1.68411740
20	BMPR1B	1.66627175
21	TESK1	1.60782207
22	RAF1	1.53938130
23	TTK	1.47843826
24	NME1	1.42451644
25	PTK2	1.41613244
26	EPHA2	1.36813791
27	RPS6KA4	1.36602582
28	CDK3	1.30029258
29	PLK3	1.28951436
30	VRK2	1.27962944
31	FGFR3	1.27178927
32	TSSK6	1.25273852
33	PNCK	1.22972228
34	EIF2AK1	1.17781007
35	STK4	1.12347386
36	AURKB	1.07812258
37	CHEK2	1.05652893
38	STK3	1.00459654
39	ACVR1B	1.00072473
40	MET	0.95587470
41	TNIK	0.91086840
42	PLK1	0.89541773
43	FGFR4	0.89499834
44	LATS1	0.88959047
45	CCNB1	0.88639157
46	VRK1	0.83282989
47	ERBB4	0.79376623
48	MAP3K2	0.78843251
49	MAP3K10	0.77459124
50	PKN1	0.75548088
51	EPHA3	0.74628323
52	WEE1	0.74618683
53	TGFBR1	0.72902416
54	PLK4	0.72588861
55	ROCK1	0.70974046
56	CAMK2G	0.70791886
57	WNK4	0.69904306
58	FGFR1	0.64576131
59	PHKG2	0.63066591
60	PHKG1	0.63066591
61	AURKA	0.61909607
62	MST1R	0.59919185
63	ATM	0.59157009
64	ABL2	0.58315727
65	CDK7	0.58236684
66	MYLK	0.56547993
67	BRSK1	0.54774169
68	STK39	0.54687827
69	PIM2	0.54060628
70	WNK3	0.53392958
71	PRKAA2	0.53169811
72	CDC7	0.51260508
73	CAMK1G	0.50595469
74	TGFBR2	0.50392863
75	MAPK11	0.50360372
76	CDK8	0.50063959
77	MAPK15	0.49963301
78	CDK9	0.46977372
79	PIK3CA	0.46715039
80	NEK2	0.46271369
81	NTRK3	0.45668874
82	ALK	0.45008670
83	ATR	0.44786700
84	CDK6	0.43659017
85	FER	0.42007381
86	STK38L	0.41857475
87	CLK1	0.40027749
88	LMTK2	0.37621401
89	CHEK1	0.36760264
90	PRKCI	0.36428568
91	MAPKAPK2	0.36387805
92	ZAK	0.35399675
93	NLK	0.35197311
94	IRAK3	0.34670407
95	MAP2K1	0.34478576
96	CDK4	0.34427599
97	PRKAA1	0.34362039
98	MAP3K12	0.34191109
99	ARAF	0.33919492
100	CSNK2A2	0.33824192

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.08962335
2	Proteasome_Homo sapiens_hsa03050	3.05988950
3	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.86677262
4	Protein export_Homo sapiens_hsa03060	2.74060847
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.66350656
6	Fatty acid elongation_Homo sapiens_hsa00062	2.51382157
7	Folate biosynthesis_Homo sapiens_hsa00790	2.37666010
8	DNA replication_Homo sapiens_hsa03030	2.34738075
9	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.33004515
10	Homologous recombination_Homo sapiens_hsa03440	2.24691566
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.23285689
12	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.22397211
13	One carbon pool by folate_Homo sapiens_hsa00670	2.12554874
14	Mismatch repair_Homo sapiens_hsa03430	2.11290532
15	Pyruvate metabolism_Homo sapiens_hsa00620	1.95659474
16	Propanoate metabolism_Homo sapiens_hsa00640	1.95088221
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86409143
18	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.70923157
19	Ribosome_Homo sapiens_hsa03010	1.67580395
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.66470549
21	Oxidative phosphorylation_Homo sapiens_hsa00190	1.52508996
22	RNA degradation_Homo sapiens_hsa03018	1.52489537
23	Butanoate metabolism_Homo sapiens_hsa00650	1.45555595
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.44390214
25	RNA transport_Homo sapiens_hsa03013	1.40610833
26	Spliceosome_Homo sapiens_hsa03040	1.40143650
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.31119623
28	RNA polymerase_Homo sapiens_hsa03020	1.29177002
29	Huntingtons disease_Homo sapiens_hsa05016	1.27387150
30	Peroxisome_Homo sapiens_hsa04146	1.26717039
31	Parkinsons disease_Homo sapiens_hsa05012	1.25887883
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23710865
33	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.23074477
34	Purine metabolism_Homo sapiens_hsa00230	1.22254678
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.21954054
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.21661415
37	Fatty acid degradation_Homo sapiens_hsa00071	1.17578811
38	Base excision repair_Homo sapiens_hsa03410	1.16680993
39	Fatty acid metabolism_Homo sapiens_hsa01212	1.12639708
40	Histidine metabolism_Homo sapiens_hsa00340	1.12557019
41	Phenylalanine metabolism_Homo sapiens_hsa00360	1.11251781
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.10433307
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.10377172
44	Lysine degradation_Homo sapiens_hsa00310	1.08527580
45	Carbon metabolism_Homo sapiens_hsa01200	1.07455870
46	Arginine and proline metabolism_Homo sapiens_hsa00330	1.02336835
47	Sulfur relay system_Homo sapiens_hsa04122	1.01375750
48	Complement and coagulation cascades_Homo sapiens_hsa04610	0.97017317
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.96206166
50	Glutathione metabolism_Homo sapiens_hsa00480	0.91984738
51	Selenocompound metabolism_Homo sapiens_hsa00450	0.89963596
52	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.87525742
53	Cell cycle_Homo sapiens_hsa04110	0.86854816
54	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.86733031
55	Alzheimers disease_Homo sapiens_hsa05010	0.85250062
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.84512412
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.80758333
58	mRNA surveillance pathway_Homo sapiens_hsa03015	0.78958164
59	Metabolic pathways_Homo sapiens_hsa01100	0.78937913
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.78469312
61	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.76806693
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.74014976
63	Basal transcription factors_Homo sapiens_hsa03022	0.73781515
64	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72755181
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.71323951
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.71137898
67	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.70152201
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.65348106
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.63653648
70	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.61620168
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.60730089
72	Arginine biosynthesis_Homo sapiens_hsa00220	0.60024611
73	Sulfur metabolism_Homo sapiens_hsa00920	0.58807195
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58307997
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.58149876
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.57989873
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.57352758
78	Sphingolipid metabolism_Homo sapiens_hsa00600	0.51674790
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.49726448
80	Galactose metabolism_Homo sapiens_hsa00052	0.47986739
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.47868850
82	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.46449157
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43538201
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42650949
85	Oocyte meiosis_Homo sapiens_hsa04114	0.42360050
86	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41744871
87	Circadian rhythm_Homo sapiens_hsa04710	0.41209938
88	Retinol metabolism_Homo sapiens_hsa00830	0.41048105
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.40972859
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39783636
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.39474807
92	Chemical carcinogenesis_Homo sapiens_hsa05204	0.39055636
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.38305838
94	Regulation of autophagy_Homo sapiens_hsa04140	0.37856343
95	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.37077534
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.34420187
97	Small cell lung cancer_Homo sapiens_hsa05222	0.31728196
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.29781031
99	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26201536
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.25592787

C1GALT1C1L

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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